Compounds > vx-745
Page last updated: 2024-09-05

vx-745 and enzastaurin

vx-745 has been researched along with enzastaurin in 2 studies

Compound Research Comparison

Studies
(vx-745)		Trials
(vx-745)		Recent Studies (post-2010)
(vx-745)		Studies
(enzastaurin)		Trials
(enzastaurin)		Recent Studies (post-2010) (enzastaurin)
581351885299

Protein Interaction Comparison

ProteinTaxonomyvx-745 (IC50)enzastaurin (IC50)
Protein kinase C gamma typeHomo sapiens (human)0.7915
Protein kinase C alpha typeRattus norvegicus (Norway rat)0.7
Protein kinase C beta typeHomo sapiens (human)0.1797
Protein kinase C delta typeRattus norvegicus (Norway rat)0.7
Protein kinase C epsilon typeRattus norvegicus (Norway rat)0.7
Protein kinase C zeta typeRattus norvegicus (Norway rat)0.7
Protein kinase C alpha typeHomo sapiens (human)0.4695
Protein kinase C eta typeHomo sapiens (human)0.4
Protein kinase C gamma typeRattus norvegicus (Norway rat)0.7
Protein kinase C beta typeRattus norvegicus (Norway rat)0.7
Protein kinase C epsilon typeHomo sapiens (human)0.38
Protein kinase C zeta typeHomo sapiens (human)8
Protein kinase C delta typeHomo sapiens (human)1
Calcium/calmodulin-dependent protein kinase type II subunit betaHomo sapiens (human)10
Calcium/calmodulin-dependent protein kinase type II subunit gammaHomo sapiens (human)10
Calcium/calmodulin-dependent protein kinase type II subunit deltaHomo sapiens (human)10
Protein kinase C eta typeRattus norvegicus (Norway rat)0.7
Calcium/calmodulin-dependent protein kinase type II subunit alphaHomo sapiens (human)10
Protein kinase C theta typeRattus norvegicus (Norway rat)0.7

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1

Other Studies

2 other study(ies) available for vx-745 and enzastaurin

ArticleYear
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013