vx 497 has been researched along with mycophenolic acid in 9 studies
| Studies (vx 497) | Trials (vx 497) | Recent Studies (post-2010) (vx 497) | Studies (mycophenolic acid) | Trials (mycophenolic acid) | Recent Studies (post-2010) (mycophenolic acid) |
|---|---|---|---|---|---|
| 25 | 3 | 7 | 9,029 | 1,506 | 3,772 |
| Protein | Taxonomy | vx 497 (IC50) | mycophenolic acid (IC50) |
|---|---|---|---|
| Inosine-5'-monophosphate dehydrogenase 2 | Homo sapiens (human) | 0.1496 | |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.014 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.014 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.014 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 0.014 | |
| Inosine-5'-monophosphate dehydrogenase 1 | Homo sapiens (human) | 0.0772 | |
| Sodium-dependent serotonin transporter | Rattus norvegicus (Norway rat) | 0.011 | |
| Inosine-5'-monophosphate dehydrogenase | Cryptococcus neoformans var. neoformans JEC21 | 0.12 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (88.89) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Barrish, JC; Bednarz, MS; Berry, KK; Chen, BC; Cheney, DL; Dhar, TG; Fleener, CA; Gu, HH; Guo, J; Harper, TW; Hollenbaugh, DL; Iwanowicz, EJ; Liu, C; MacMaster, JF; McIntyre, KW; Miller, LM; Pitts, WJ; Rouleau, KA; Shen, Z; Sherbina, NZ; Shuster, DJ; Tredup, JA; Watterson, SH; Witmer, MR; Zhao, R | 1 |
| Carlsen, M; Chen, P; Chorba, J; Dhar, TG; Fleener, CA; Gu, HH; Guo, J; Haslow, KD; Hollenbaugh, D; Iwanowicz, EJ; Norris, D; Pitts, WJ; Rouleau, KA; Shen, Z; Townsend, R; Watterson, SH | 1 |
| Ballentine, SK; Barrish, JC; Chen, P; Dhar, TG; Fleener, CA; Gu, HH; Hollenbaugh, DL; Iwanowicz, EJ; Norris, D; Rouleau, KA; Shen, Z; Townsend, R; Watterson, SH | 1 |
| Gahan, ME; Keller, PA; Mahalingam, S; Stevens, AJ | 1 |
| Agard, DA; Ashworth, A; Barrio-Hernandez, I; Batra, J; Beltrao, P; Bennett, MJ; Bohn, M; Bouhaddou, M; Braberg, H; Broadhurst, DJ; Cai, Y; Cakir, M; Calviello, L; Cavero, DA; Chang, JCJ; Chorba, JS; Craik, CS; d'Enfert, C; Dai, SA; Eckhardt, M; Emerman, M; Fabius, JM; Fletcher, SJ; Floor, SN; Foussard, H; Frankel, AD; Fraser, JS; Fujimori, DG; Ganesan, SJ; García-Sastre, A; Gordon, DE; Gross, JD; Guo, JZ; Haas, K; Haas, P; Hernandez-Armenta, C; Hiatt, J; Huang, XP; Hubert, M; Hüttenhain, R; Ideker, T; Jacobson, M; Jang, GM; Jura, N; Kaake, RM; Kim, M; Kirby, IT; Klippsten, S; Koh, C; Kortemme, T; Krogan, NJ; Kuzuoglu-Ozturk, D; Li, Q; Liboy-Lugo, J; Lin, Y; Liu, X; Liu, Y; Lou, K; Lyu, J; Mac Kain, A; Malik, HS; Mathy, CJP; McGregor, MJ; Melnyk, JE; Memon, D; Meyer, B; Miorin, L; Modak, M; Moreno, E; Mukherjee, S; Naing, ZZC; Noack, J; O'Meara, MJ; O'Neal, MC; Obernier, K; Ott, M; Peng, S; Perica, T; Pilla, KB; Polacco, BJ; Rakesh, R; Rathore, U; Rezelj, VV; Richards, AL; Roesch, F; Rosenberg, OS; Rosenthal, SB; Roth, BL; Roth, TL; Ruggero, D; Safari, M; Sali, A; Saltzberg, DJ; Savar, NS; Schwartz, O; Sharp, PP; Shen, W; Shengjuler, D; Shi, Y; Shoichet, BK; Shokat, KM; Soucheray, M; Stroud, RM; Subramanian, A; Swaney, DL; Taunton, J; Tran, QD; Trenker, R; Tummino, TA; Tutuncuoglu, B; Ugur, FS; Vallet, T; Venkataramanan, S; Verba, KA; Verdin, E; Vignuzzi, M; von Zastrow, M; Wang, HY; Wankowicz, SA; Wenzell, NA; White, KM; Xu, J; Young, JM; Zhang, Z; Zhou, Y | 1 |
| Chen, P; Cheney, DL; Fleener, CA; Gu, HH; Guo, J; Hollenbaugh, DL; Iwanowicz, EJ; Murali Dhar, TG; Pitts, WJ; Rouleau, KA; Shen, Z; Townsend, RM; Watterson, SH | 1 |
| Baroudy, BM; Liu, R; Malcolm, BA; Reyes, GR; Zhou, S | 1 |
| Almquist, SJ; Ford, PJ; Germann, UA; Jain, J; Nimmesgern, E; Shlyakhter, D; Wang, Y | 1 |
| Pockros, PJ; Shields, WW | 1 |
1 review(s) available for vx 497 and mycophenolic acid
| Article | Year |
|---|---|
The medicinal chemistry of dengue fever.
Topics: Antiviral Agents; Dengue; Dengue Virus; Humans; Models, Molecular; Viral Proteins | 2009 |
8 other study(ies) available for vx 497 and mycophenolic acid
| Article | Year |
|---|---|
Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.
Topics: Animals; Antibody Formation; Arthritis, Experimental; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; IMP Dehydrogenase; Male; Mice; Mice, Inbred BALB C; Morpholines; Mycophenolic Acid; Oxazoles; Rats; Rats, Inbred Lew; Structure-Activity Relationship | 2002 |
Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues.
Topics: Enzyme Inhibitors; Humans; IMP Dehydrogenase; Quinolones; Stereoisomerism; Structure-Activity Relationship | 2003 |
3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.
Topics: Catalysis; Enzyme Inhibitors; IMP Dehydrogenase; Indoles; Kinetics; Structure-Activity Relationship | 2003 |
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Topics: Animals; Antiviral Agents; Betacoronavirus; Chlorocebus aethiops; Cloning, Molecular; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Evaluation, Preclinical; Drug Repositioning; HEK293 Cells; Host-Pathogen Interactions; Humans; Immunity, Innate; Mass Spectrometry; Molecular Targeted Therapy; Pandemics; Pneumonia, Viral; Protein Binding; Protein Biosynthesis; Protein Domains; Protein Interaction Mapping; Protein Interaction Maps; Receptors, sigma; SARS-CoV-2; SKP Cullin F-Box Protein Ligases; Vero Cells; Viral Proteins | 2020 |
Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.
Topics: Animals; Carbamates; Cell Line; Cricetinae; Cricetulus; Enzyme Inhibitors; IMP Dehydrogenase; Inhibitory Concentration 50; Lymphocyte Activation; Mycophenolic Acid; Oxazoles; Phenylurea Compounds; Structure-Activity Relationship; T-Lymphocytes | 2003 |
The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA.
Topics: Antimetabolites; Carbamates; Cell Line, Transformed; Enzyme Inhibitors; Genome, Viral; Guanosine; Hepacivirus; Humans; IMP Dehydrogenase; Mutation; Mycophenolic Acid; Phenylurea Compounds; Replicon; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; RNA; RNA, Viral; Transfection; Virus Replication | 2003 |
Regulation of inosine monophosphate dehydrogenase type I and type II isoforms in human lymphocytes.
Topics: Carbamates; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Isoenzymes; Leukocytes, Mononuclear; Lymphocytes; Mycophenolic Acid; Phenylurea Compounds; RNA, Messenger; Tumor Cells, Cultured | 2004 |
Ribavirin analogs.
Topics: Anemia, Hemolytic; Antiviral Agents; Carbamates; Hepacivirus; Hepatitis C; Humans; IMP Dehydrogenase; Mycophenolic Acid; Phenylurea Compounds; Ribavirin | 2009 |