Page last updated: 2024-09-04

vx 497 and carbamates

vx 497 has been researched along with carbamates in 14 studies

Compound Research Comparison

Studies
(vx 497)
Trials
(vx 497)
Recent Studies (post-2010)
(vx 497)
Studies
(carbamates)
Trials
(carbamates)
Recent Studies (post-2010) (carbamates)
253713,7179854,744

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's13 (92.86)29.6817
2010's1 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jain, J; Kwong, AD; Markland, W; McQuaid, TJ1
Almquist, SJ; Harding, MW; Jain, J; Shlyakhter, D1
McHutchison, JG; Shad, JA1
Chaturvedi, PR; Decker, CJ; Faust, TJ; Heiser, AD; Ku, G; Moseley, S; Nimmesgern, E1
Chen, P; Cheney, DL; Fleener, CA; Gu, HH; Guo, J; Hollenbaugh, DL; Iwanowicz, EJ; Murali Dhar, TG; Pitts, WJ; Rouleau, KA; Shen, Z; Townsend, RM; Watterson, SH1
Baroudy, BM; Liu, R; Malcolm, BA; Reyes, GR; Zhou, S1
Almquist, SJ; Ford, PJ; Germann, UA; Jain, J; Nimmesgern, E; Shlyakhter, D; Wang, Y1
Alam, J; Cheung, RC; Ette, E; Gordon, SC; McHutchison, JG; McNair, L; Moseley, S; Pottage, JC; Shiffman, ML; Wright, TL1
Beevers, RE; Buckley, GM; Davies, N; Fraser, JL; Galvin, FC; Hannah, DR; Haughan, AF; Jenkins, K; Mack, SR; Pitt, WR; Ratcliffe, AJ; Richard, MD; Sabin, V; Sharpe, A; Williams, SC1
Kochling, JD; Looker, AR; Miao, H; Montgomery, ER; Shannon, M; Young, CR1
Alam, J; Bengtsson, L; Bronowicki, JP; Garg, V; Grange, JD; Horsmans, Y; Marcellin, P; McNair, L; Nevens, F; Purdy, S; Vetter, D1
Pockros, PJ; Shields, WW1
Aalyson, M; Afdhal, N; Alam, J; Bengtsson, L; Bonkovsky, HL; Chandorkar, G; Gharakhanian, S; Gordon, SC; Harding, M; Kauffman, R; Lawitz, E; Lee, WM; McHutchison, JG; McNair, L; Poordad, F; Rustgi, VK1
Bukreyeva, N; Kalkeri, R; Koma, T; Kwong, AD; Manning, JT; Paessler, S; Smith, J; Tong, X1

Reviews

1 review(s) available for vx 497 and carbamates

ArticleYear
Current and future therapies of hepatitis C.
    Clinics in liver disease, 2001, Volume: 5, Issue:2

    Topics: Antiviral Agents; Carbamates; Drug Therapy, Combination; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Hepacivirus; Hepatitis C, Chronic; Humans; Immunization, Passive; Immunologic Factors; IMP Dehydrogenase; Interferon-alpha; Phenylurea Compounds; Ribavirin; RNA, Viral

2001

Trials

3 trial(s) available for vx 497 and carbamates

ArticleYear
A randomized, double-blind, placebo-controlled dose-escalation trial of merimepodib (VX-497) and interferon-alpha in previously untreated patients with chronic hepatitis C.
    Antiviral therapy, 2005, Volume: 10, Issue:5

    Topics: Administration, Oral; Adolescent; Adult; Aged; Antiviral Agents; Carbamates; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; IMP Dehydrogenase; Injections, Subcutaneous; Interferon-alpha; Male; Middle Aged; Phenylurea Compounds

2005
Phase 2 study of the combination of merimepodib with peginterferon-alpha2b, and ribavirin in nonresponders to previous therapy for chronic hepatitis C.
    Journal of hepatology, 2007, Volume: 47, Issue:4

    Topics: Adult; Antiviral Agents; Carbamates; Drug Therapy, Combination; Female; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Phenylurea Compounds; Placebos; Polyethylene Glycols; Recombinant Proteins; Ribavirin; RNA, Viral; Treatment Outcome

2007
Merimepodib, pegylated interferon, and ribavirin in genotype 1 chronic hepatitis C pegylated interferon and ribavirin nonresponders.
    Hepatology (Baltimore, Md.), 2009, Volume: 50, Issue:6

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Carbamates; Double-Blind Method; Drug Therapy, Combination; Female; Hepatitis C, Chronic; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Phenylurea Compounds; Polyethylene Glycols; Recombinant Proteins; Ribavirin

2009

Other Studies

10 other study(ies) available for vx 497 and carbamates

ArticleYear
Broad-spectrum antiviral activity of the IMP dehydrogenase inhibitor VX-497: a comparison with ribavirin and demonstration of antiviral additivity with alpha interferon.
    Antimicrobial agents and chemotherapy, 2000, Volume: 44, Issue:4

    Topics: Animals; Antiviral Agents; Carbamates; Cattle; Cell Line; Cytopathogenic Effect, Viral; Electrophoresis; Enzyme Inhibitors; Fibroblasts; Guanosine; Humans; IMP Dehydrogenase; Interferon-alpha; Mice; Molecular Weight; Phenylurea Compounds; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; Signal Transduction; Viral Plaque Assay; Virus Replication; Viruses

2000
VX-497: a novel, selective IMPDH inhibitor and immunosuppressive agent.
    Journal of pharmaceutical sciences, 2001, Volume: 90, Issue:5

    Topics: Animals; B-Lymphocytes; Carbamates; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunosuppressive Agents; IMP Dehydrogenase; Keratinocytes; Male; Mice; Mice, Inbred C57BL; Phenylurea Compounds; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; T-Lymphocytes

2001
The novel IMPDH inhibitor VX-497 prolongs skin graft survival and improves graft versus host disease in mice.
    Drugs under experimental and clinical research, 2001, Volume: 27, Issue:3

    Topics: Animals; Carbamates; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Graft Rejection; Graft Survival; Graft vs Host Disease; Immunosuppressive Agents; IMP Dehydrogenase; Interferon-gamma; Mice; Mice, Inbred Strains; Models, Animal; Phenylurea Compounds; Skin; Skin Transplantation; Spleen

2001
Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.
    Bioorganic & medicinal chemistry letters, 2003, Jun-16, Volume: 13, Issue:12

    Topics: Animals; Carbamates; Cell Line; Cricetinae; Cricetulus; Enzyme Inhibitors; IMP Dehydrogenase; Inhibitory Concentration 50; Lymphocyte Activation; Mycophenolic Acid; Oxazoles; Phenylurea Compounds; Structure-Activity Relationship; T-Lymphocytes

2003
The effect of ribavirin and IMPDH inhibitors on hepatitis C virus subgenomic replicon RNA.
    Virology, 2003, Jun-05, Volume: 310, Issue:2

    Topics: Antimetabolites; Carbamates; Cell Line, Transformed; Enzyme Inhibitors; Genome, Viral; Guanosine; Hepacivirus; Humans; IMP Dehydrogenase; Mutation; Mycophenolic Acid; Phenylurea Compounds; Replicon; Reverse Transcriptase Polymerase Chain Reaction; Ribavirin; RNA; RNA, Viral; Transfection; Virus Replication

2003
Regulation of inosine monophosphate dehydrogenase type I and type II isoforms in human lymphocytes.
    Biochemical pharmacology, 2004, Feb-15, Volume: 67, Issue:4

    Topics: Carbamates; Enzyme Inhibitors; Humans; IMP Dehydrogenase; Isoenzymes; Leukocytes, Mononuclear; Lymphocytes; Mycophenolic Acid; Phenylurea Compounds; RNA, Messenger; Tumor Cells, Cultured

2004
Low molecular weight indole fragments as IMPDH inhibitors.
    Bioorganic & medicinal chemistry letters, 2006, May-01, Volume: 16, Issue:9

    Topics: Carbamates; Crystallography, X-Ray; Enzyme Inhibitors; Hydrogen Bonding; IMP Dehydrogenase; Indoles; Models, Molecular; Molecular Structure; Molecular Weight; Oxazoles; Phenylurea Compounds; Sensitivity and Specificity; Structure-Activity Relationship

2006
Understanding the degradation pathway of a poorly water-soluble drug formulated in PEG-400.
    Journal of pharmaceutical and biomedical analysis, 2007, Apr-11, Volume: 43, Issue:5

    Topics: Capsules; Carbamates; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Drug Contamination; Hydrolysis; Mass Spectrometry; Molecular Structure; Pharmaceutical Preparations; Phenylurea Compounds; Polyethylene Glycols; Solubility; Solutions; Temperature; Time Factors; Water

2007
Ribavirin analogs.
    Clinics in liver disease, 2009, Volume: 13, Issue:3

    Topics: Anemia, Hemolytic; Antiviral Agents; Carbamates; Hepacivirus; Hepatitis C; Humans; IMP Dehydrogenase; Mycophenolic Acid; Phenylurea Compounds; Ribavirin

2009
Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens.
    Antiviral research, 2018, Volume: 149

    Topics: Animals; Antiviral Agents; Carbamates; Cell Line; Chlorocebus aethiops; Ebolavirus; Humans; IMP Dehydrogenase; Phenylurea Compounds; RNA, Viral; Vero Cells; Virus Replication; Zika Virus; Zika Virus Infection

2018