vulpinic-acid and pulvinic-acid

vulpinic-acid has been researched along with pulvinic-acid* in 2 studies

Other Studies

2 other study(ies) available for vulpinic-acid and pulvinic-acid

Article	Year
Evaluation of antioxidant properties of monoaromatic derivatives of pulvinic acids. Journal of medicinal chemistry, 2009, Apr-23, Volume: 52, Issue:8 The natural mushroom pigment Norbadione A and three other pulvinic acids were shown by our group to display very efficient antioxidant properties by comparison with a collection of potent molecules including catechols, flavonoids, stilbenes, or coumarins. Despite numerous publications on robust and straightforward synthetic access to pulvinic acids by us and others, no report has been made to unravel the structure-activity relationships that govern the striking antioxidant activity. Herein is presented the synthesis of 18 diverse pulvinic acid derivatives and the study of their radical scavenging capacities by four different assays. The influence of each of the two phenyl rings, of their substituents and of the lateral chain on the antioxidant properties, was explored to reveal a simplified structure of excellent activity. These results, along with the absence of cytotoxicity, make the synthesized compounds interesting to evaluate for several biological activities and especially for anti-inflammatory effects and skin protection against UV induced oxidative stress. Topics: Animals; Antioxidants; Carboxylic Acids; CHO Cells; Cricetinae; Cricetulus; DNA, Superhelical; Free Radical Scavengers; Lactones; Oxidative Stress; Stereoisomerism; Structure-Activity Relationship; Superoxides; Thymidine; Ultraviolet Rays	2009
Chemical constituents of the lichen, Candelaria concolor: a complete NMR and chemical degradative investigation. Natural product research, 2009, Volume: 23, Issue:10 A detailed chemical and spectroscopic investigation of the terrestrial lichen Candelaria concolor has yielded several lichenic metabolites belonging to the pulvinic acid series, as well as several depside derivatives including pulvinic dilactone (1), vulpinic acid (4) and calycin (5). The chemical transformation of 1 to pulvinic acid (3) is reported for the first time, as is the conversion of atranorin (6) to 5-chloroatranorin (7) and then finally to 5,5'-dichloroatranorin (8) under very mild conditions. Also presented is the complete 1D and 2D NMR assignment for compounds 1, 3, 4, 5 and 8, including partial NMR chemical shift assignments for the unstable depside (7). Previously, these metabolites had only been partially assigned by NMR spectroscopy. Topics: Carboxylic Acids; Furans; Hydroxybenzoates; Lactones; Lichens; Magnetic Resonance Spectroscopy; Molecular Structure; Phenylacetates; Plant Extracts	2009

Article

Year

Evaluation of antioxidant properties of monoaromatic derivatives of pulvinic acids.

Journal of medicinal chemistry, 2009, Apr-23, Volume: 52, Issue:8

The natural mushroom pigment Norbadione A and three other pulvinic acids were shown by our group to display very efficient antioxidant properties by comparison with a collection of potent molecules including catechols, flavonoids, stilbenes, or coumarins. Despite numerous publications on robust and straightforward synthetic access to pulvinic acids by us and others, no report has been made to unravel the structure-activity relationships that govern the striking antioxidant activity. Herein is presented the synthesis of 18 diverse pulvinic acid derivatives and the study of their radical scavenging capacities by four different assays. The influence of each of the two phenyl rings, of their substituents and of the lateral chain on the antioxidant properties, was explored to reveal a simplified structure of excellent activity. These results, along with the absence of cytotoxicity, make the synthesized compounds interesting to evaluate for several biological activities and especially for anti-inflammatory effects and skin protection against UV induced oxidative stress.

Topics: Animals; Antioxidants; Carboxylic Acids; CHO Cells; Cricetinae; Cricetulus; DNA, Superhelical; Free Radical Scavengers; Lactones; Oxidative Stress; Stereoisomerism; Structure-Activity Relationship; Superoxides; Thymidine; Ultraviolet Rays

2009

Chemical constituents of the lichen, Candelaria concolor: a complete NMR and chemical degradative investigation.

Natural product research, 2009, Volume: 23, Issue:10

A detailed chemical and spectroscopic investigation of the terrestrial lichen Candelaria concolor has yielded several lichenic metabolites belonging to the pulvinic acid series, as well as several depside derivatives including pulvinic dilactone (1), vulpinic acid (4) and calycin (5). The chemical transformation of 1 to pulvinic acid (3) is reported for the first time, as is the conversion of atranorin (6) to 5-chloroatranorin (7) and then finally to 5,5'-dichloroatranorin (8) under very mild conditions. Also presented is the complete 1D and 2D NMR assignment for compounds 1, 3, 4, 5 and 8, including partial NMR chemical shift assignments for the unstable depside (7). Previously, these metabolites had only been partially assigned by NMR spectroscopy.

Topics: Carboxylic Acids; Furans; Hydroxybenzoates; Lactones; Lichens; Magnetic Resonance Spectroscopy; Molecular Structure; Phenylacetates; Plant Extracts

2009