vt-1161 has been researched along with posaconazole* in 2 studies
2 other study(ies) available for vt-1161 and posaconazole
| Article | Year |
|---|---|
Azole Resistance Reduces Susceptibility to the Tetrazole Antifungal VT-1161.
Tetrazole antifungals designed to target fungal lanosterol 14α-demethylase (LDM) appear to be effective against a range of fungal pathogens. In addition, a crystal structure of the catalytic domain of Topics: Amino Acid Sequence; Antifungal Agents; ATP-Binding Cassette Transporters; Candida albicans; Candida glabrata; Catalytic Domain; Cloning, Molecular; Crystallography, X-Ray; Drug Resistance, Fungal; Fungal Proteins; Gene Expression; Genetic Vectors; Microbial Sensitivity Tests; Models, Molecular; Mutation; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Pyridines; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Sterol 14-Demethylase; Substrate Specificity; Tetrazoles; Triazoles | 2019 |
Prophylactic Treatment with VT-1161 Protects Immunosuppressed Mice from Rhizopus arrhizus var. arrhizus Infection.
We compared prophylactic or continuous therapy with the investigational drug VT-1161 to that with posaconazole in treating murine mucormycosis due to Topics: Animals; Antifungal Agents; Immunocompromised Host; Male; Mice; Microbial Sensitivity Tests; Mucormycosis; Protective Agents; Pyridines; Rhizopus; Tetrazoles; Triazoles | 2017 |