vortioxetine and dapoxetine

The studies aimed to determine the antidepressant efficacy of single and chronic administration of dapoxetine alone and vortioxetine alone, as well as in the combination of these drugs. An additional objective of the study was to measure the effect of the active substances on the corticosterone level in chronically stressed animals. The study was conducted on male Wistar rats using non‑stressed and stressed groups (chronic restraint stress). The experiment comprised both forced swimming test (immobility time test) and corticosterone level measurement using Corticosterone ELISA Kit. The obtained results confirm the antidepressant efficacy of used drugs upon both single and chronic administration and potential efficacy of these drugs administered in combination with stressed rats. Corticosterone level analysis, meanwhile, showed stress relieving properties of the study drugs, which reduced the animal stress hormone level, whether administered separately or in combination. Dapoxetine and vortioxetine have an antidepressant and stress relieving effect on rats subject to chronic stress both in monotherapy and in combined therapy. Because both study drugs are new additions on the market, further research is necessary to prevent interactions related, for instance, with uncontrolled use of two drugs with similar mechanisms of action but prescribed in different indications (dapoxetine is commonly used to treat premature ejaculation).

Topics: Animals; Antidepressive Agents; Behavior, Animal; Benzylamines; Corticosterone; Depression; Male; Naphthalenes; Rats, Wistar; Stress, Psychological; Vortioxetine

Depression is a highly prevalent social disease. Despite significant medical progress, therapeutic solutions for optimising treatment of this disease are still being sought. The aim of this study was to assess, using the forced swimming test, locomotor activity test and two compartment exploratory test, for a reduction in immobility time (a measure of anti-depressant efficacy), locomotor activity and anxiolytic effectiveness after single, repeated, and combined administration of vortioxetine (2.5 mg/kg - a multimodal SMS), dapoxetine (3.0 mg/kg - an SSRI used in premature ejaculation disorders) and fluoxetine (5.0 mg/kg - an SSRI) in non-stressed and prenatally stressed rats. It was found that vortioxetine, fluoxetine and dapoxetine reduced immobility time and rat locomotor activity which suggests anti-depressant efficacy of these drugs both in monotherapy and in combined administration. The results also confirmed an anxiolytic effect of the study drugs in mono and combined therapy. Analysis of the pathomechanism of depression and the mechanisms of action of the individual drugs tested resulted in a prediction that combined administration of these drugs may be effective in the treatment of depressive disorders, although possible interactions between the drugs used must be assessed for. Considering the fact that dapoxetine is not currently used in depression treatment and vortioxetine is a relatively new drug, further research in this direction is vital, including within animal models.

Topics: Animals; Antidepressive Agents; Benzylamines; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Exploratory Behavior; Female; Fluoxetine; Immobility Response, Tonic; Locomotion; Male; Naphthalenes; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Statistics, Nonparametric; Stress, Psychological; Swimming; Time Factors; Treatment Outcome; Vortioxetine