vortioxetine and asenapine

Many psychoactive compounds have been developed to have more beneficial clinical efficacy than conventional drugs by adding agonistic action at 5-HT. The [. The specific binding was stimulated by brexpiprazole in rat hippocampus, human hippocampus, and human prefrontal cortex. Aripiprazole also behaved as an agonist in the same brain regions. Interestingly, its potency was much higher in rat hippocampal membranes than in human brain membranes, indicating the possibility of species differences. Although vortioxetine was an efficacious stimulator at high concentrations, its potency was undeterminable because of a lack of saturability. In addition to 5-HT. Our previous studies have raised the concept of a psychoactive drug group with a common pharmacological mechanism of action, i.e., 5-HT

Topics: Animals; Aripiprazole; Brain; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lurasidone Hydrochloride; Psychotropic Drugs; Rats; Receptor, Serotonin, 5-HT1A; Serotonin; Serotonin Receptor Agonists; Vortioxetine