Compounds > vorozole
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vorozole and triazoles

vorozole has been researched along with triazoles in 113 studies

Research

Studies (113)

TimeframeStudies, this research(%)All Research%
pre-19902 (1.77)18.7374
1990's59 (52.21)18.2507
2000's32 (28.32)29.6817
2010's19 (16.81)24.3611
2020's1 (0.88)2.80

Authors

AuthorsStudies
Callens, M; De Coster, R; Janssens, B; Krekels, MD; Van Ginckel, R; Wouters, W1
Balthazart, J; De Clerck, A; Foidart, A1
Callens, MJ; De Coster, R; Goeminne, NK; Janssens, BL; Van Ginckel, RF1
Bowden, CR; Morris, DM; Tuman, RW; Wallace, NH1
De Coster, R; Janssen, PA; Krekels, MD; Leonaers, A; Van Ginckel, R; Wouters, W1
Byloos, M; De Coster, R; Goeminne, N; Van Ginckel, R; Vanherck, W; Wouters, W1
De Coster, R; Dillen, A; Freyne, E; Krekels, MD; Raeymaekers, A; Sanz, G; van Dun, J; Van Gelder, J; Venet, M; Wouters, W1
Bellens, D; Janssen, PA; Roels, I; Vanden Bossche, H; Willemsens, G1
Bellens, D; Coene, MC; Janssen, PA; Lauwers, W; Le Jeune, L; Moereels, H; Roels, I; Vanden Bossche, H; Willemsens, G1
Bowden, CR; Bruynseels, J; De Coster, R; Janssen, PA; Snoeck, E; Tuman, RW; Van Ginckel, R; Van Peer, A; Vanden Bossche, H; Wouters, W1
Balthazart, J; Evrard, L; Surlemont, C1
De Coster, R; Krekels, MD; Wouters, W1
Beerens, D; De Coster, R; Doolaege, R; Gruwez, JA; Van Camp, K; Van Der Pas, H; van Herendael, B; Wouters, W1
Amery, WK; Bowden, CR; Bruynseels, J; De Coster, R; Janssen, PA; Tuman, RW; Van Rooy, P; Vanderpas, H; Wouters, W1
Beerens, D; De Coster, R; Freyne, E; Haelterman, C; Krekels, M; Raeymaekers, A; van Dun, J; Van Gelder, J; Venet, M; Wouters, W1
Amarneh, B; Graham-Lorence, S; Peterson, JA; Simpson, ER; White, RE1
Balthazart, J; Foidart, A; Harada, N2
Koymans, LM; Moereels, H; Vanden Bossche, H1
Balthazart, J; Foidart, A1
De Coster, R; Snoeck, E; Wouters, W1
Casebolt, TL; Eto, I; Grubbs, CJ; Kelloff, GJ; Lubet, RA; Steele, VE1
Bowden, C; De Coster, R; Krekels, M; Van Ginckel, R; Wouters, W1
Berghman, LR; Decuypere, E; Rombauts, L; Vanmontfort, D; Verhoeven, G1
Blankenstein, MA; de Frankrijker, E; Donker, TH; Nortier, HW; Thijssen, JH; van der Wall, E1
Aimar, P; Aste, N; Balthazart, J; Foidart, A; Panzica, GC; Viglietti-Panzica, C1
Callens, M; De Coster, R; Goeminne, N; Janssens, B; Van Ginckel, R; Wouters, L1
Bouillon, R; De Coster, R; Van Herck, E; Vanderschueren, D1
Harada, N; Rissman, EF; Roselli, CE1
Absil, P; Ball, GF; Balthazart, J; Foidart, A; Harada, N; Houbart, M1
Ball, GF; Balthazart, J; Castagna, C1
Bouillon, R; De Coster, R; Ederveen, AG; Nijs, J; van Herck, E; Vanderschueren, D1
Blankenstein, RA; de Jong, PC; Donker, TH; Maitimu-Smeele, I; Nortier, HW; Slee, PH; Thijssen, JH; van de Ven, J1
Dowsett, M2
Spencer, CM; Wiseman, LR1
Durgam, VR; Tekmal, RR1
Amoroso, D; Boccardo, F; Brema, F; Cortesi, E; Farris, A; Guida, G; Iacobelli, S; Irtelli, L; Langenaeken, C; Mesiti, M; Mustacchi, G; Nardini, P; Pacini, P1
Buzdar, AU; Roseman, BJ; Singletary, SE1
Harada, N; Hatano, O1
Beex, LV; Houston, SJ; Klijn, J; Langenaeken, C; Nooij, M; Paridaens, R; Piccart, MJ; Roy, JA; Tomiak, E; Van Glabbeke, M; Van Vreckem, A; Vinholes, J1
Buyse, J; De Coster, R; Decuypere, E; Dewil, E; Mast, J; Veldhuis, JD1
Harvey, HA1
Beex, LV; Bonfrer, JM; Bruning, PF; Bruynseels, J; Klijn, JG; Nooij, M; Paridaens, R; Piccart, MJ1
Huang, ML; Langenaecken, C; Piotrovsky, VK; Van Peer, A1
Bowden, C; DeCoster, R; Eto, I; Grubbs, CJ; Juliana, MM; Kelloff, GJ; Lubet, RA; Steele, VE; You, M1
Goss, PE1
Ambus, U; Bruynseels, J; Clark, RM; Crump, M; De Coster, R; Goss, PE; Tye, LM; Wadden, NA; Walde, D; Weizel, HA1
Balthazart, J; Castagna, C; Panzica, GC; Russo, C; Tlemçani, O; Viglietti-Panzica, C1
Bureau, R; Dallemagne, P; Enguehard, C; Galopin, S; Guillon, J; Moslemi, S; Rault S Auvray, P; Séralini, GE; Sonnet, P; Sourdiane, P1
Iino, Y; Koibuchi, Y; Morishita, Y; Sugamata, N1
Hoogmartens, J; Jimidar, M; Niemeijer, N; Peeters, R1
Bruynseels, J; De Coster, R; Goss, PE; Langenaeken, C; Walde, D1
Hamilton, A; Piccart, M1
Bergström, M; Bergström-Pettermann, E; Bonasera, TA; Carlström, K; Holte, J; Kirilovas, D; Långström, B; Naessen, T; Simberg, N2
Goss, PE; Schwartz, LH; Tannock, IF; Winer, EP1
Blijham, GH; de Jong, PC1
Coombes, RC; Doody, D; Dowsett, M; English, J; Howes, A; Miall, S1
Bonneterre, J; Feutrie, ML1
Grubbs, CJ; Khan, SA; Lubet, RA; Nephew, KP; Osborne, E1
Harvey, HA; Santen, RJ1
Bajetta, E; Bichisao, E; Pozzi, P; Toffolatti, L; Zilembo, N1
Christov, K; Green, A; Grubbs, C; Kelloff, G; Lubet, R; Mehta, RG; Shilkaitis, A1
Christov, K; Graves, J; Hu, L; Kelloff, G; Lubet, R; Mehta, RR; Shilkaitis, A; Steele, V; You, M1
Boonen, S; Bouillon, R; de Coster, R; Ederveen, AG; Moermans, K; Van Herck, E; Vandenput, L; Vanderschueren, D; Verstuyf, A1
Auvray, P; Bichat, F; Genne, P1
de Crémoux, P1
Kerbrat, P; Lefeuvre, C1
Buzdar, A; Howell, A1
Boeddinghaus, I; Dixon, M; Dowsett, M; Ebbs, S; Gui, G; Harper-Wynne, C; Hills, M; Sacks, N; Salter, J; Smith, I1
Crist, KA; Grubbs, CJ; Hu, L; Johanning, GL; Lubet, RA; Wang, M; Wang, Y; Yao, R; You, M1
Knott, KK; Lubet, RA; McGinley, JN; Steele, VE; Thompson, HJ1
A'Hern, R; Doody, D; Dowsett, M; Harper-Wynne, CL; Hills, MJ; Howes, A; Iqbal, J; Laidlaw, IJ; Lowe, FM; MacNeill, FA; Miall, S; Nasiri, N; Rayter, Z; Sacks, NP; Salter, J; Sauven, P; Shenton, K1
Bijnens, L; Michiels, B; Molenberghs, G; Thijs, H; Vangeneugden, T1
Mokbel, K1
Bergström, M; Bergström-Petterman, E; Carlström, K; Kirilovas, D; Långström, B; Naessen, T1
Balthazart, J; Evrard, HC2
Balthazart, J; Cornil, CA; Holloway, KS; Taziaux, M1
Clemons, MJ; Freedman, OC; Verma, S1
Baillien, M; Ball, GF; Balthazart, J; Cornil, CA; Taziaux, M1
Bria, E; Carlini, P; Cognetti, F; Di Cosimo, S; Fabi, A; Felici, A; Ferretti, G; Giannarelli, D; Milella, M; Mottolese, M; Nisticò, C; Papaldo, P; Ruggeri, EM; Terzoli, E1
Diani-Moore, S; Labitzke, E; Papachristou, F; Rifkind, AB1
Bergström, M; Frändberg, P; Långström, B; Takahashi, K; Vesström, EL; Watanabe, Y1
Ioannidis, JP; Mauri, D; Pavlidis, N; Polyzos, NP1
Bergström, M; Bergström-Petterman, E; Carlström, K; Chaika, A; Kirilovas, D; Korniyenko, S; Mogilevkina, I; Naessen, T; Nosenko, J; Yakovets, A1
Bergström, M; Hallberg, M; Långström, B; Magnusson, K; Nyberg, F; Takahashi, K; Watanabe, Y1
Bergström, M; Långström, B; Takahashi, K; Tamura, Y; Watanabe, Y1
Bode, AM; Christov, K; Ericson, ME; Grubbs, CJ; Juliana, MM; Lubet, RA; Steele, VE; Szabo, E1
Lenie, S; Smitz, J1
Alexoff, DL; Biegon, A; Carter, P; Ehrlich, CW; Fowler, JS; Hooker, JM; Katsamanis, ZE; Kim, SW; King, P; Muench, L; Shea, C; Xu, Y1
Alonso, A; Laenen, A1
Biegon, A; Fowler, JS; Hooker, JM; Kim, SW; Logan, J; Muench, L1
Jiao, J; Liao, Q; Xiang, H1
Alexoff, DL; Biegon, A; Carter, P; Fowler, JS; Hubbard, B; Jayne, M; Kim, SW; King, P; Logan, J; Muench, L; Pareto, D; Schlyer, D; Shea, C; Telang, F; Wang, GJ; Xu, Y1
Doi, H; Hiramatsu, T; Hosoya, A; Hosoya, T; Nagata, H; Onoe, H; Onoe, K; Takahashi, K; Wada, Y; Watanabe, Y; Yamagishi, G1
Bergström, M; Doi, H; Hosoya, T; Långström, B; Mizuma, H; Nagata, H; Onoe, H; Onoe, K; Takahashi, K; Takashima, T; Tamura, Y; Wada, Y; Watanabe, Y; Yamagishi, G; Yamanaka, H; Yokoyama, C1
Mahon, MF; Potter, BV; Purohit, A; Thomas, MP; Woo, LW; Wood, PM1
A'Hern, R; Anderson, H; Bliss, J; Dowsett, M; Dunbier, A; Evans, A; Ghazoui, Z; Iskender, A; Johnson, L; Pinhel, I; Robertson, J; Robison, L; Salter, J; Skene, T; Smith, I; Wilcox, M1
Akazawa, KH; Cui, Y; Doi, H; Hosoya, T; Kataoka, Y; Nagata, H; Ozawa, M; Takahashi, K; Takashima, T; Wada, Y; Watanabe, Y1
Ball, GF; Balthazart, J; Cornil, CA; de Meaultsart, CC1
Hosoya, T; Kusuhara, H; Miyajima, M; Sugiyama, Y; Takahashi, K; Takashima, T; Watanabe, Y1
Garbow, JR; He, J; Higashikubo, R; Jones, LA; Lubet, RA; Mach, RH; Rowland, D; Shoghi, KI; Su, Y; Tu, Z; Wheeler, KT; Xu, J; Yan, Y; You, M1
Doi, H; Hiramatsu, T; Hosoya, T; Li, XL; Nagata, H; Onoe, H; Onoe, K; Suzuki, M; Takahashi, K; Takashima, T; Wada, Y; Watanabe, Y1
Biegon, A; Fowler, JS; Kim, SW; Logan, J; Pareto, D; Telang, F; Wang, GJ1
Alexoff, DL; Biegon, A; Fowler, JS; Kim, SW; Logan, J; Pareto, D; Schlyer, D; Wang, GJ1
Ball, GF; Balthazart, J; Cornil, CA; Seredynski, AL1
Ball, GF; Balthazart, J; Cornil, CA; de Bournonville, C1
Bode, A; Grubbs, CJ; Juliana, MM; Lubet, RA; Moeinpour, F; Steele, VE1
Ball, GF; Balthazart, J; Cornil, CA; de Bournonville, MP; Vandries, LM1
Airola, K; Biegon, A; Bonilla, P; Cohen, J; Dhawan, J; Franceschi, D; Pareto, D; Shroyer, KR; Tahmi, M1

Reviews

22 review(s) available for vorozole and triazoles

ArticleYear
From 14 alpha-demethylase inhibitors in fungal cells to androgen and oestrogen biosynthesis inhibitors in mammalian cells.
    Biochemical Society transactions, 1990, Volume: 18, Issue:1

    Topics: Androgen Antagonists; Animals; Antifungal Agents; Cells, Cultured; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Estrogen Antagonists; Humans; Imidazoles; Ketoconazole; Oxidoreductases; Sterol 14-Demethylase; Triazoles

1990
New non-steroidal aromatase inhibitors: focus on R76713.
    The Journal of steroid biochemistry and molecular biology, 1990, Nov-20, Volume: 37, Issue:3

    Topics: Animals; Aromatase Inhibitors; Female; Humans; Male; Pregnancy; Triazoles

1990
Vorozole, a specific non-steroidal aromatase inhibitor.
    Breast cancer research and treatment, 1994, Volume: 30, Issue:1

    Topics: Animals; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estradiol; Female; Hormones; Humans; In Vitro Techniques; Male; Mammary Neoplasms, Experimental; Triazoles

1994
Vorozole.
    Drugs & aging, 1997, Volume: 11, Issue:3

    Topics: Anastrozole; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles

1997
Use of aromatase inhibitors in postmenopausal women with advanced breast cancer.
    Journal of surgical oncology, 1997, Volume: 66, Issue:3

    Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles

1997
Emerging role of aromatase inhibitors in the treatment of breast cancer.
    Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:3 Suppl 5

    Topics: Aged; Aminoglutethimide; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Megestrol Acetate; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Triazoles

1998
Theoretical considerations for the ideal aromatase inhibitor.
    Breast cancer research and treatment, 1998, Volume: 49 Suppl 1

    Topics: Aminoglutethimide; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles

1998
Pre-clinical and clinical review of vorozole, a new third generation aromatase inhibitor.
    Breast cancer research and treatment, 1998, Volume: 49 Suppl 1

    Topics: Animals; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Enzyme Inhibitors; Humans; Neoplasms, Hormone-Dependent; Randomized Controlled Trials as Topic; Triazoles

1998
The third-generation non-steroidal aromatase inhibitors: a review of their clinical benefits in the second-line hormonal treatment of advanced breast cancer.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1999, Volume: 10, Issue:4

    Topics: Aged; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Belgium; Breast Neoplasms; Clinical Trials as Topic; Disease Progression; Female; Humans; Letrozole; Middle Aged; Neoplasm Metastasis; Nitriles; Postmenopause; Severity of Illness Index; Survival Rate; Tamoxifen; Treatment Outcome; Triazoles

1999
New aromatase inhibitors for the treatment of advanced breast cancer in postmenopausal women.
    The Netherlands journal of medicine, 1999, Volume: 55, Issue:2

    Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Triazoles

1999
[Aromatase inhibitors].
    Bulletin du cancer, 1999, Volume: 86, Issue:10

    Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Estrogen Antagonists; Estrone; Female; Humans; Letrozole; Nitriles; Triazoles

1999
Use of aromatase inhibitors in breast carcinoma.
    Endocrine-related cancer, 1999, Volume: 6, Issue:1

    Topics: Adult; Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Middle Aged; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Tamoxifen; Triazoles

1999
Steroidal aromatase inhibitors in elderly patients.
    Critical reviews in oncology/hematology, 2000, Volume: 33, Issue:2

    Topics: Aged; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Triazoles

2000
[Preclinical evaluation of aromatase inhibitors antitumor activity].
    Bulletin du cancer, 2000, Volume: 87 Spec No

    Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Models, Animal; Nitriles; Rats; Structure-Activity Relationship; Triazoles

2000
[Aromatase inhibitors: pharmacological aspects].
    Bulletin du cancer, 2000, Volume: 87 Spec No

    Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles

2000
[Aromatase inhibitors: a review of clinical trials].
    Bulletin du cancer, 2000, Volume: 87 Spec No

    Topics: Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Nitriles; Randomized Controlled Trials as Topic; Triazoles

2000
Advances in aromatase inhibition: clinical efficacy and tolerability in the treatment of breast cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:9

    Topics: Anastrozole; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Fadrozole; Female; Headache; Humans; Letrozole; Nausea; Nitriles; Treatment Outcome; Triazoles; Vomiting

2001
The evolving role of aromatase inhibitors in breast cancer.
    International journal of clinical oncology, 2002, Volume: 7, Issue:5

    Topics: Anastrozole; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Humans; Letrozole; Nitriles; Triazoles

2002
Using aromatase inhibitors in the neoadjuvant setting: evolution or revolution?
    Cancer treatment reviews, 2005, Volume: 31, Issue:1

    Topics: Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neoplasms; Evidence-Based Medicine; Female; Humans; Letrozole; Mastectomy, Segmental; Neoadjuvant Therapy; Nitriles; Randomized Controlled Trials as Topic; Receptors, Estrogen; Survival Analysis; Tamoxifen; Treatment Outcome; Triazoles

2005
New aromatase inhibitors as second-line endocrine therapy in postmenopausal patients with metastatic breast carcinoma: a pooled analysis of the randomized trials.
    Cancer, 2005, Oct-01, Volume: 104, Issue:7

    Topics: Aged; Anastrozole; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carcinoma; Clinical Trials, Phase III as Topic; Confidence Intervals; Dose-Response Relationship, Drug; Drug Administration Schedule; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Probability; Prognosis; Remission Induction; Risk Assessment; Survival Analysis; Triazoles

2005
Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis.
    Journal of the National Cancer Institute, 2006, Sep-20, Volume: 98, Issue:18

    Topics: Adult; Aged; Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Odds Ratio; Randomized Controlled Trials as Topic; Survival Analysis; Triazoles

2006
Recent advancement in nonsteroidal aromatase inhibitors for treatment of estrogen-dependent breast cancer.
    Current medicinal chemistry, 2010, Volume: 17, Issue:30

    Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Chromones; Coumarins; Female; Flavonoids; Humans; Letrozole; Nitriles; Receptors, Estrogen; Sulfonamides; Triazoles

2010

Trials

10 trial(s) available for vorozole and triazoles

ArticleYear
Aromatase inhibition by R 76713: experimental and clinical pharmacology.
    Journal of steroid biochemistry, 1989, Volume: 34, Issue:1-6

    Topics: Adult; Aldosterone; Animals; Aromatase Inhibitors; Diet, Sodium-Restricted; Estradiol; Female; Humans; Macaca fascicularis; Male; Rats; Rats, Inbred Strains; Reference Values; Renin; Triazoles

1989
Inhibition of the in vivo conversion of androstenedione to estrone by the aromatase inhibitor vorozole in healthy postmenopausal women.
    Cancer research, 1993, Oct-01, Volume: 53, Issue:19

    Topics: Aged; Androstenedione; Aromatase Inhibitors; Carbon Radioisotopes; Double-Blind Method; Estrone; Female; Humans; Postmenopause; Triazoles; Tritium

1993
Inhibition of breast cancer tissue aromatase activity and estrogen concentrations by the third-generation aromatase inhibitor vorozole.
    Cancer research, 1997, Jun-01, Volume: 57, Issue:11

    Topics: Aged; Antineoplastic Agents; Aromatase; Breast Neoplasms; Estradiol; Estrogens; Estrone; Female; Humans; Middle Aged; Triazoles

1997
Clinical efficacy and endocrine activity of vorozole in postmenopausal breast cancer patients. Results of a multicentric phase II study.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:8

    Topics: Aged; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrone; Female; Humans; Middle Aged; Postmenopause; Triazoles

1997
Vorozole (Rivizor): an active and well tolerated new aromatase inhibitor for the treatment of advanced breast cancer patients with prior tamoxifen exposure. Investigational Drug Branch of the European Organization for Research and Treatment of Cancer (EOR
    Anti-cancer drugs, 1998, Volume: 9, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogen Antagonists; Female; Hot Flashes; Humans; Middle Aged; Nausea; Tamoxifen; Triazoles

1998
Vorozole (R83842) in the treatment of postmenopausal advanced breast cancer: relationship of serum levels of vorozole and clinical results (a study of the EORTC Breast Cancer Cooperative Group).
    Anti-cancer drugs, 1998, Volume: 9, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Female; Hormones; Humans; Middle Aged; Postmenopause; Statistics as Topic; Treatment Outcome; Triazoles

1998
Phase II study of vorozole (R83842), a new aromatase inhibitor, in postmenopausal women with advanced breast cancer in progression on tamoxifen.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 1995, Volume: 1, Issue:3

    Topics: Aged; Aged, 80 and over; Aldosterone; Androgens; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Estrogens; Female; Follicle Stimulating Hormone; Humans; Hydrocortisone; Luteinizing Hormone; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

1995
Randomized phase III trial comparing the new potent and selective third-generation aromatase inhibitor vorozole with megestrol acetate in postmenopausal advanced breast cancer patients. North American Vorozole Study Group.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1999, Volume: 17, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease Progression; Enzyme Inhibitors; Female; Humans; Megestrol Acetate; Middle Aged; Postmenopause; Triazoles

1999
Vorozole results in greater oestrogen suppression than formestane in postmenopausal women and when added to goserelin in premenopausal women with advanced breast cancer.
    Breast cancer research and treatment, 1999, Volume: 56, Issue:1

    Topics: Adult; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Estradiol; Female; Goserelin; Humans; Middle Aged; Ovary; Postmenopause; Premenopause; Triazoles

1999
Comparison of the systemic and intratumoral effects of tamoxifen and the aromatase inhibitor vorozole in postmenopausal patients with primary breast cancer.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2002, Feb-15, Volume: 20, Issue:4

    Topics: Administration, Oral; Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Enzyme Inhibitors; Female; Follicle Stimulating Hormone; Humans; Ki-67 Antigen; Luteinizing Hormone; Middle Aged; Postmenopause; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Triazoles

2002

Other Studies

81 other study(ies) available for vorozole and triazoles

ArticleYear
Aromatase inhibition by R 83 842, the dextro isomer of R 76 713, in JEG-3 choriocarcinoma grown in ovariectomized nude mice.
    The Journal of steroid biochemistry and molecular biology, 1992, Volume: 41, Issue:3-8

    Topics: Animals; Aromatase Inhibitors; Cell Line; Choriocarcinoma; Female; Humans; Isomerism; Mice; Mice, Nude; Neoplasm Transplantation; Pregnancy; Transplantation, Heterologous; Triazoles; Tumor Cells, Cultured; Uterine Neoplasms

1992
Behavioral demasculinization of female quail is induced by estrogens: studies with the new aromatase inhibitor, R76713.
    Hormones and behavior, 1992, Volume: 26, Issue:2

    Topics: Animals; Aromatase Inhibitors; Copulation; Coturnix; Dose-Response Relationship, Drug; Estradiol; Female; Male; Sex Differentiation; Sexual Behavior, Animal; Sexual Maturation; Testosterone; Triazoles

1992
Antitumoral and endocrine effects of (+)-vorozole in rats bearing dimethylbenzanthracene-induced mammary tumors.
    Cancer research, 1992, Mar-01, Volume: 52, Issue:5

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aromatase Inhibitors; Drug Administration Schedule; Drug Screening Assays, Antitumor; Estradiol; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Mammary Neoplasms, Experimental; Ovariectomy; Random Allocation; Rats; Rats, Inbred Strains; Triazoles

1992
Inhibition of peripheral aromatization in the male cynomolgus monkey by a novel nonsteroidal aromatase inhibitor (R 76713).
    The Journal of clinical endocrinology and metabolism, 1991, Volume: 72, Issue:4

    Topics: Androstenedione; Animals; Aromatase Inhibitors; Dose-Response Relationship, Drug; Estrone; Injections, Intravenous; Macaca fascicularis; Male; Pharmaceutical Vehicles; Triazoles

1991
Aromatase in the human choriocarcinoma JEG-3: inhibition by R 76 713 in cultured cells and in tumors grown in nude mice.
    The Journal of steroid biochemistry and molecular biology, 1991, Volume: 38, Issue:4

    Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Binding, Competitive; Choriocarcinoma; Female; Humans; Kinetics; Mice; Mice, Nude; Substrate Specificity; Testosterone; Triazoles; Tumor Cells, Cultured

1991
Endocrine and antitumoral effects of R76713 in rats.
    Journal of enzyme inhibition, 1990, Volume: 4, Issue:2

    Topics: Adrenal Cortex Hormones; Adrenal Glands; Animals; Antineoplastic Agents; Aromatase Inhibitors; Body Weight; Estradiol; Female; Luteinizing Hormone; Mammary Neoplasms, Experimental; Organ Size; Ovariectomy; Ovary; Progesterone; Rats; Rats, Inbred Strains; Triazoles; Uterus

1990
Comparative effects of the aromatase inhibitor R76713 and of its enantiomers R83839 and R83842 on steroid biosynthesis in vitro and in vivo.
    The Journal of steroid biochemistry and molecular biology, 1990, Dec-20, Volume: 37, Issue:6

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Animals; Aromatase Inhibitors; Estradiol; Female; Gonadotropin-Releasing Hormone; Gonadotropins, Equine; Granulosa Cells; In Vitro Techniques; Male; Ovary; Rats; Stereoisomerism; Steroid Hydroxylases; Steroids; Testis; Testosterone; Triazoles

1990
R 76713 and enantiomers: selective, nonsteroidal inhibitors of the cytochrome P450-dependent oestrogen synthesis.
    Biochemical pharmacology, 1990, Oct-15, Volume: 40, Issue:8

    Topics: Adrenal Glands; Androgens; Androstenedione; Animals; Aromatase Inhibitors; Cattle; Cytochrome P-450 Enzyme Inhibitors; Estrogens; Female; Male; Microsomes; Placenta; Rabbits; Rats; Spectrophotometry; Stereoisomerism; Swine; Testis; Triazoles

1990
Effects of the nonsteroidal inhibitor R76713 on testosterone-induced sexual behavior in the Japanese quail (Coturnix coturnix japonica).
    Hormones and behavior, 1990, Volume: 24, Issue:4

    Topics: Animals; Aromatase Inhibitors; Brain Mapping; Copulation; Coturnix; Estradiol; Male; Preoptic Area; Sexual Behavior, Animal; Testosterone; Triazoles

1990
Aromatase inhibition by R 76 713: a kinetic analysis in rat ovarian homogenates.
    Steroids, 1990, Volume: 55, Issue:2

    Topics: Androstenedione; Animals; Aromatase Inhibitors; Female; Kinetics; Ovary; Rats; Rats, Inbred Strains; Testosterone; Triazoles

1990
Potency and selectivity of the aromatase inhibitor R 76,713. A study in human ovarian, adipose stromal, testicular and adrenal cells.
    Journal of steroid biochemistry, 1990, Volume: 36, Issue:1-2

    Topics: Adipose Tissue; Adrenal Glands; Aromatase Inhibitors; Binding, Competitive; Cells, Cultured; Female; Humans; Kinetics; Male; Ovary; Steroids; Testis; Triazoles

1990
R 76713, a new specific non-steroidal aromatase inhibitor.
    Journal of steroid biochemistry, 1989, Volume: 32, Issue:6

    Topics: Adrenal Glands; Aminoglutethimide; Animals; Aromatase Inhibitors; Cells, Cultured; Dose-Response Relationship, Drug; Estradiol; Female; Granulosa Cells; Male; Rats; Rats, Inbred Strains; Receptors, Androgen; Receptors, Estrogen; Receptors, Glucocorticoid; Receptors, Progesterone; Testis; Triazoles

1989
A three-dimensional model of aromatase cytochrome P450.
    Protein science : a publication of the Protein Society, 1995, Volume: 4, Issue:6

    Topics: Amino Acid Sequence; Aromatase; Bacterial Proteins; Camphor 5-Monooxygenase; Catalysis; Computer Simulation; Conserved Sequence; Cytochrome P-450 Enzyme System; Mixed Function Oxygenases; Models, Chemical; Models, Molecular; Molecular Sequence Data; NADPH-Ferrihemoprotein Reductase; Sequence Alignment; Sequence Homology, Amino Acid; Triazoles

1995
Aromatase-immunoreactive cells are present in mouse brain areas that are known to express high levels of aromatase activity.
    Cell and tissue research, 1995, Volume: 280, Issue:3

    Topics: Animals; Aromatase; Brain; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Triazoles

1995
A molecular model for the interaction between vorozole and other non-steroidal inhibitors and human cytochrome P450 19 (P450 aromatase).
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 53, Issue:1-6

    Topics: Amino Acid Sequence; Androstenedione; Aromatase; Aromatase Inhibitors; Binding Sites; Humans; In Vitro Techniques; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment; Triazoles

1995
Sexual differentiation of brain and behavior in quail and zebra finches: studies with a new aromatase inhibitor, R76713.
    The Journal of steroid biochemistry and molecular biology, 1995, Volume: 53, Issue:1-6

    Topics: Animals; Aromatase Inhibitors; Behavior, Animal; Birds; Coturnix; Female; Male; Rodentia; Sex Differentiation; Triazoles; Vocalization, Animal

1995
Effects of steroidal and non steroidal aromatase inhibitors on sexual behavior and aromatase-immunoreactive cells and fibers in the quail brain.
    Brain research, 1994, Sep-19, Volume: 657, Issue:1-2

    Topics: Androstenedione; Animals; Aromatase Inhibitors; Brain; Coturnix; Drug Implants; Immunoenzyme Techniques; Male; Nerve Fibers; Sexual Behavior, Animal; Testosterone; Triazoles

1994
Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats.
    Carcinogenesis, 1994, Volume: 15, Issue:12

    Topics: Adenocarcinoma; Aminoglutethimide; Androstenedione; Animals; Anticarcinogenic Agents; Aromatase Inhibitors; Drug Screening Assays, Antitumor; Estrus; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Triazoles

1994
Pharmacology of vorozole.
    The Journal of steroid biochemistry and molecular biology, 1993, Volume: 44, Issue:4-6

    Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aldosterone; Animals; Aromatase Inhibitors; Cell Division; Cells, Cultured; Choriocarcinoma; Chorionic Gonadotropin; Corticosterone; Estradiol; Female; Follicle Stimulating Hormone; Granulosa Cells; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Organ Size; Pregnancy; Rats; Receptors, Glucocorticoid; Receptors, Progesterone; Receptors, Steroid; Testis; Testosterone; Triazoles; Uterine Neoplasms; Uterus

1993
Changes in immunoreactive FSH and inhibin in developing chicken embryos and the effects of estradiol and the aromatase inhibitor R76713.
    Biology of reproduction, 1993, Volume: 49, Issue:3

    Topics: Animals; Aromatase Inhibitors; Chick Embryo; Estradiol; Female; Follicle Stimulating Hormone; Inhibins; Male; Time Factors; Triazoles

1993
Implication of testosterone metabolism in the control of the sexually dimorphic nucleus of the quail preoptic area.
    Brain research bulletin, 1993, Volume: 31, Issue:5

    Topics: Animals; Aromatase Inhibitors; Coturnix; Female; Image Processing, Computer-Assisted; Male; Neurons; Orchiectomy; Preoptic Area; Sex Characteristics; Sexual Behavior, Animal; Testosterone; Triazoles

1993
Effects of combined and sequential treatment with tamoxifen and the aromatase inhibitor vorozole on 7,12-dimethylbenz(a) anthracene-induced mammary carcinoma in the rat.
    Cancer chemotherapy and pharmacology, 1996, Volume: 38, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Carcinogens; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Female; Luteinizing Hormone; Mammary Neoplasms, Experimental; Ovariectomy; Progesterone; Rats; Rats, Sprague-Dawley; Tamoxifen; Triazoles

1996
Aromatization of androgens is important for skeletal maintenance of aged male rats.
    Calcified tissue international, 1996, Volume: 59, Issue:3

    Topics: Absorptiometry, Photon; Aging; Amino Acids; Analysis of Variance; Androgens; Animals; Aromatase Inhibitors; Bone Density; Bone Development; Bone Resorption; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrogens; Femur; Lumbar Vertebrae; Male; Orchiectomy; Osteocalcin; Osteoporosis; Rats; Rats, Wistar; Triazoles

1996
Effect of vorozole, an aromatase enzyme inhibitor, on sexual behavior, aromatase activity and neural immunoreactivity.
    Journal of neuroendocrinology, 1996, Volume: 8, Issue:3

    Topics: Animals; Aromatase Inhibitors; Brain; Brain Chemistry; Estrogens; Female; Immunohistochemistry; Male; Neurons; Sex Characteristics; Sexual Behavior, Animal; Shrews; Triazoles

1996
Distribution of aromatase-immunoreactive cells in the forebrain of zebra finches (Taeniopygia guttata): implications for the neural action of steroids and nuclear definition in the avian hypothalamus.
    Journal of neurobiology, 1996, Volume: 31, Issue:2

    Topics: Animals; Antibody Specificity; Aromatase; Aromatase Inhibitors; Biomarkers; Birds; Brain Chemistry; Enzyme Inhibitors; Immunohistochemistry; Male; Neurons; Paraventricular Hypothalamic Nucleus; Preoptic Area; Prosencephalon; Sex Factors; Steroids; Telencephalon; Triazoles; Vasotocin

1996
Aromatase inhibition blocks the activation and sexual differentiation of appetitive male sexual behavior in Japanese quail.
    Behavioral neuroscience, 1997, Volume: 111, Issue:2

    Topics: Animals; Appetitive Behavior; Aromatase; Aromatase Inhibitors; Copulation; Coturnix; Enzyme Inhibitors; Estrogens; Female; Libido; Male; Sex Differentiation; Sexual Behavior, Animal; Testosterone; Triazoles

1997
Clinical development plan: (+)-vorozole.
    Journal of cellular biochemistry. Supplement, 1996, Volume: 26

    Topics: Animals; Anticarcinogenic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Drug Approval; Enzyme Inhibitors; Estradiol; Female; Humans; Male; Neoplasms, Experimental; Rats; Research Design; Triazoles

1996
Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats.
    Endocrinology, 1997, Volume: 138, Issue:6

    Topics: Absorptiometry, Photon; Aging; Animals; Aromatase Inhibitors; Body Weight; Bone Density; Bone Development; Bone Remodeling; Enzyme Inhibitors; Femur; Insulin-Like Growth Factor I; Male; Orchiectomy; Rats; Rats, Wistar; Reference Values; Triazoles

1997
Aromatase inhibitors come of age.
    Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:7

    Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Nitriles; Triazoles

1997
A novel in vitro and in vivo breast cancer model for testing inhibitors of estrogen biosynthesis and its action using mammary tumor cells with an activated int-5/aromatase gene.
    Cancer letters, 1997, Sep-16, Volume: 118, Issue:1

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoglutethimide; Analysis of Variance; Anastrozole; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Enzyme Inhibitors; Fadrozole; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Nitriles; Ovariectomy; Postmenopause; Triazoles; Tumor Cells, Cultured

1997
Inhibitors of aromatase prevent degradation of the enzyme in cultured human tumour cells.
    British journal of cancer, 1998, Volume: 77, Issue:4

    Topics: Androstenedione; Aromatase; Aromatase Inhibitors; Carcinoma, Hepatocellular; Choriocarcinoma; Colforsin; Cycloheximide; Enzyme-Linked Immunosorbent Assay; Fadrozole; Humans; Liver Neoplasms; Neoplasm Proteins; Protein Synthesis Inhibitors; RNA, Messenger; Triazoles; Tumor Cells, Cultured

1998
In ovo treatment with an aromatase inhibitor masculinizes postnatal hormone levels, abdominal fat pad content, and GH pulsatility in broiler chickens.
    Domestic animal endocrinology, 1998, Volume: 15, Issue:2

    Topics: Adipose Tissue; Analysis of Variance; Animals; Aromatase Inhibitors; Body Composition; Body Weight; Chick Embryo; Chickens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Female; Growth Hormone; Injections; Male; Random Allocation; Sex Characteristics; Testosterone; Thyroxine; Time Factors; Triazoles; Triiodothyronine

1998
Effects of demographic variables on vorozole pharmacokinetics in healthy volunteers and in breast cancer patients.
    Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:3

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Body Height; Body Weight; Breast Neoplasms; Female; Humans; Male; Middle Aged; Population; Regression Analysis; Sex Factors; Triazoles

1998
Chemopreventive effects of the aromatase inhibitor vorozole (R 83842) in the methylnitrosourea-induced mammary cancer model.
    Carcinogenesis, 1998, Volume: 19, Issue:8

    Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Body Weight; Carcinogens; Drug Administration Schedule; Drug Screening Assays, Antitumor; Estradiol; Estrus; Female; Genes, ras; Insulin-Like Growth Factor I; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Testosterone; Triazoles

1998
Organizational effects of estrogens on brain vasotocin and sexual behavior in quail.
    Journal of neurobiology, 1998, Volume: 37, Issue:4

    Topics: Analysis of Variance; Animals; Aromatase Inhibitors; Body Weight; Brain Chemistry; Cloaca; Coturnix; Embryo, Nonmammalian; Estradiol; Female; Immunohistochemistry; Male; Neurons; Preoptic Area; Sex Characteristics; Sexual Behavior, Animal; Testosterone; Triazoles; Vasotocin

1998
Design and synthesis of a new type of non steroidal human aromatase inhibitors.
    Bioorganic & medicinal chemistry letters, 1998, May-05, Volume: 8, Issue:9

    Topics: Aromatase Inhibitors; Drug Design; Enzyme Inhibitors; Fadrozole; Female; Humans; Indicators and Reagents; Indolizines; Microsomes; Placenta; Pregnancy; Pyridines; Structure-Activity Relationship; Triazoles

1998
A novel aromatase inhibitor, vorozole, shows antitumor activity and a decrease of tissue insulin-like growth factor-I level in 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumors.
    International journal of oncology, 1999, Volume: 14, Issue:2

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Antineoplastic Agents; Aromatase Inhibitors; Enzyme Inhibitors; Female; Insulin-Like Growth Factor I; Mammary Neoplasms, Experimental; Rats; Triazoles

1999
Robustness testing of a liquid chromatography method for the determination of vorozole and its related compounds in oral tablets.
    Journal of pharmaceutical and biomedical analysis, 1998, Volume: 18, Issue:4-5

    Topics: Antineoplastic Agents; Chromatography, Liquid; Enzyme Inhibitors; Sensitivity and Specificity; Tablets; Triazoles

1998
Rivizor--a new third-generation aromatase inhibitor for the treatment of advanced breast cancer after tamoxifen failure.
    Oncology, 1999, Volume: 56, Issue:2

    Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Carcinoembryonic Antigen; Disease Progression; Enzyme Inhibitors; Estrogen Antagonists; Female; Gonadal Steroid Hormones; Humans; Middle Aged; Tamoxifen; Time Factors; Treatment Failure; Treatment Outcome; Triazoles

1999
In vitro evaluation of aromatase enzyme in granulosa cells using a [11C]vorozole binding assay.
    Steroids, 1999, Volume: 64, Issue:4

    Topics: Aromatase; Aromatase Inhibitors; Carbon Radioisotopes; Enzyme Inhibitors; Female; Granulosa Cells; Humans; Triazoles

1999
Effects of oral administration of tamoxifen, toremifene, dehydroepiandrosterone, and vorozole on uterine histomorphology in the rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 2000, Volume: 223, Issue:3

    Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Dehydroepiandrosterone; Female; Mammary Neoplasms, Animal; Rats; Rats, Sprague-Dawley; Tamoxifen; Toremifene; Triazoles; Uterus

2000
Cellular responses of mammary carcinomas to aromatase inhibitors: effects of vorozole.
    Breast cancer research and treatment, 2000, Volume: 60, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Aromatase Inhibitors; Biomarkers, Tumor; Cell Division; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Female; Mammary Neoplasms, Experimental; Rats; Rats, Sprague-Dawley; Triazoles

2000
Bcl-2 and Bax are differentially expressed in hyperplastic, premalignant, and malignant lesions of mammary carcinogenesis.
    Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 2000, Volume: 11, Issue:8

    Topics: Animals; Apoptosis; Aromatase Inhibitors; bcl-2-Associated X Protein; Carcinoma; Epithelial Cells; Female; Hyperplasia; Mammary Glands, Animal; Mammary Neoplasms, Animal; Precancerous Conditions; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; RNA, Messenger; Triazoles

2000
Skeletal effects of estrogen deficiency as induced by an aromatase inhibitor in an aged male rat model.
    Bone, 2000, Volume: 27, Issue:5

    Topics: Aging; Animals; Aromatase Inhibitors; Body Weight; Bone and Bones; Bone Density; Bone Remodeling; Enzyme Inhibitors; Estradiol; Estrogens; Male; Models, Animal; Rats; Rats, Wistar; Triazoles

2000
HER-2 amplification impedes the antiproliferative effects of hormone therapy in estrogen receptor-positive primary breast cancer.
    Cancer research, 2001, Dec-01, Volume: 61, Issue:23

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cell Division; Female; Gene Amplification; Humans; Immunohistochemistry; Ki-67 Antigen; Multicenter Studies as Topic; Nitriles; Randomized Controlled Trials as Topic; Receptor, ErbB-2; Receptors, Estrogen; Tamoxifen; Triazoles

2001
Altered gene expression profile in chemically induced rat mammary adenocarcinomas and its modulation by an aromatase inhibitor.
    Oncogene, 2001, Nov-22, Volume: 20, Issue:53

    Topics: Adenocarcinoma; Amino Acid Sequence; Animals; Aromatase; Aromatase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization; Mammary Neoplasms, Experimental; Methylnitrosourea; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Neoplasm; Sequence Homology, Amino Acid; Triazoles; Up-Regulation

2001
Effect of the aromatase inhibitor vorozole on estrogen and progesterone receptor content of rat mammary carcinomas induced by 1-methyl-1-nitrosourea.
    Breast cancer research and treatment, 2001, Volume: 70, Issue:3

    Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Cell Division; Diet; Drug Administration Schedule; Epithelial Cells; Female; Immunoenzyme Techniques; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, Progesterone; Triazoles

2001
Selection models and pattern-mixture models to analyse longitudinal quality of life data subject to drop-out.
    Statistics in medicine, 2002, Apr-30, Volume: 21, Issue:8

    Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Female; Humans; Longitudinal Studies; Models, Statistical; Neoplasms, Hormone-Dependent; Patient Dropouts; Quality of Life; Triazoles

2002
Effects of androgens on aromatase activity and 11C-vorozole binding in granulosa cells in vitro.
    Acta obstetricia et gynecologica Scandinavica, 2003, Volume: 82, Issue:3

    Topics: Androgens; Androstenedione; Aromatase; Aromatase Inhibitors; Binding, Competitive; Dihydrotestosterone; Enzyme Inhibitors; Etiocholanolone; Female; Granulosa Cells; Humans; Statistics, Nonparametric; Testosterone; Triazoles

2003
Characterization of [11C]vorozole binding in ovarian tissue in rats throughout estrous cycle in association with conversion of androgens to estrogens in vivo and in vitro.
    Steroids, 2003, Volume: 68, Issue:14

    Topics: Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Binding Sites; Enzyme Inhibitors; Estradiol; Estrous Cycle; Estrus; Female; In Vitro Techniques; Luteinizing Hormone; Ovary; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Triazoles

2003
Aromatization of androgens into estrogens reduces response latency to a noxious thermal stimulus in male quail.
    Hormones and behavior, 2004, Volume: 45, Issue:3

    Topics: Analysis of Variance; Animals; Aromatase; Aromatase Inhibitors; Avoidance Learning; Coturnix; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Hot Temperature; Male; Perception; Random Allocation; Reaction Time; Tamoxifen; Testosterone; Triazoles

2004
Rapid regulation of pain by estrogens synthesized in spinal dorsal horn neurons.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Aug-18, Volume: 24, Issue:33

    Topics: Animals; Aromatase Inhibitors; Behavior, Animal; Catheterization; Cerebral Ventricles; Coturnix; Enzyme Inhibitors; Estradiol; Estrogens; Hot Temperature; Injections, Spinal; Kinetics; Male; Orchiectomy; Pain; Posterior Horn Cells; Testosterone; Triazoles

2004
The effects of aromatase inhibition on testosterone-dependent conditioned rhythmic cloacal sphincter movements in male Japanese quail.
    Physiology & behavior, 2004, Oct-30, Volume: 83, Issue:1

    Topics: Animals; Aromatase Inhibitors; Body Weight; Cloaca; Conditioning, Operant; Coturnix; Defecation; Enzyme Inhibitors; Female; Male; Movement; Testosterone; Triazoles

2004
Rapid effects of aromatase inhibition on male reproductive behaviors in Japanese quail.
    Hormones and behavior, 2006, Volume: 49, Issue:1

    Topics: Animals; Appetitive Behavior; Aromatase; Aromatase Inhibitors; Cloaca; Consummatory Behavior; Coturnix; Estradiol; Hypothalamus; In Vitro Techniques; Male; Motor Activity; Orchiectomy; Preoptic Area; Sexual Behavior, Animal; Social Environment; Testosterone; Triazoles

2006
Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:8

    Topics: Animals; Arachidonic Acids; Aromatase Inhibitors; Benzimidazoles; Cell Line, Tumor; Chick Embryo; Cytochrome P-450 Enzyme System; Enzyme Induction; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Mice; Microsomes, Liver; Phenobarbital; Polychlorinated Dibenzodioxins; RNA, Messenger; Triazoles

2006
Imaging of aromatase distribution in rat and rhesus monkey brains with [11C]vorozole.
    Nuclear medicine and biology, 2006, Volume: 33, Issue:5

    Topics: Animals; Aromatase; Brain; Carbon Radioisotopes; Female; Macaca mulatta; Male; Metabolic Clearance Rate; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Species Specificity; Tissue Distribution; Triazoles

2006
Granulosa cell aromatase enzyme activity: effects of follicular fluid from patients with polycystic ovary syndrome, using aromatase conversion and [11C]vorozole-binding assays.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2006, Volume: 22, Issue:12

    Topics: Aromatase; Diagnostic Techniques, Radioisotope; Estrogens; Female; Follicular Fluid; Granulosa Cells; Humans; Polycystic Ovary Syndrome; Substrate Specificity; Triazoles

2006
Increase in [11C]vorozole binding to aromatase in the hypothalamus in rats treated with anabolic androgenic steroids.
    Neuroreport, 2007, Jan-22, Volume: 18, Issue:2

    Topics: Androgens; Animals; Aromatase; Aromatase Inhibitors; Autoradiography; Carbon Radioisotopes; Disease Models, Animal; Hypothalamus; Male; Nandrolone; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Septal Nuclei; Substance-Related Disorders; Triazoles

2007
Alteration in [11C]vorozole binding to aromatase in neuronal cells of rat brain induced by anabolic androgenic steroids and flutamide.
    Neuroreport, 2008, Mar-05, Volume: 19, Issue:4

    Topics: Amygdala; Androgen Antagonists; Androgens; Animals; Aromatase; Aromatase Inhibitors; Binding, Competitive; Brain; Brain Mapping; Carbon Radioisotopes; Flutamide; Male; Neurons; Positron-Emission Tomography; Preoptic Area; Rats; Rats, Sprague-Dawley; Receptors, Androgen; Septal Nuclei; Triazoles; Up-Regulation

2008
Effects of gefitinib (Iressa) on mammary cancers: preventive studies with varied dosages, combinations with vorozole or targretin, and biomarker changes.
    Molecular cancer therapeutics, 2008, Volume: 7, Issue:4

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bexarotene; Biomarkers, Tumor; Carcinogens; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Therapy, Combination; ErbB Receptors; Female; Gefitinib; Immunoenzyme Techniques; Mammary Neoplasms, Experimental; Methylnitrosourea; Phosphorylation; Quinazolines; Rats; Rats, Sprague-Dawley; Tetrahydronaphthalenes; Triazoles

2008
Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles.
    Toxicology letters, 2009, Mar-28, Volume: 185, Issue:3

    Topics: Aminoglutethimide; Animals; Animals, Newborn; Diethylhexyl Phthalate; Dose-Response Relationship, Drug; Endocrine Disruptors; Female; In Vitro Techniques; Ketoconazole; Mice; Mice, Inbred Strains; Ovarian Follicle; Sensitivity and Specificity; Steroids; Toxicity Tests; Triazoles

2009
Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase.
    Nuclear medicine and biology, 2009, Volume: 36, Issue:3

    Topics: Alkylation; Animals; Aromatase; Brain; Chromatography, High Pressure Liquid; Female; Hydrocarbons, Iodinated; Magnetic Resonance Spectroscopy; Papio; Positron-Emission Tomography; Radioactive Tracers; Stereoisomerism; Time Factors; Triazoles

2009
The Functional Living Index-Cancer: estimating its reliability based on clinical trial data.
    Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2010, Volume: 19, Issue:1

    Topics: Aged; Antineoplastic Agents; Belgium; Breast Neoplasms; Discriminant Analysis; Female; Humans; Longitudinal Studies; Megestrol Acetate; Middle Aged; Patient Participation; Psychometrics; Quality of Life; Reproducibility of Results; Surveys and Questionnaires; Triazoles

2010
Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons.
    Biological psychiatry, 2010, Apr-15, Volume: 67, Issue:8

    Topics: Animals; Aromatase Inhibitors; Brain; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Magnetic Resonance Imaging; Nicotine; Nicotinic Agonists; Papio; Positron-Emission Tomography; Triazoles

2010
Unique distribution of aromatase in the human brain: in vivo studies with PET and [N-methyl-11C]vorozole.
    Synapse (New York, N.Y.), 2010, Volume: 64, Issue:11

    Topics: Adult; Aromatase; Aromatase Inhibitors; Brain; Brain Mapping; Female; Humans; Male; Positron-Emission Tomography; Protein Binding; Radiopharmaceuticals; Tissue Distribution; Triazoles; Young Adult

2010
Practical synthesis of precursor of [N-methyl-11C]vorozole, an efficient PET tracer targeting aromatase in the brain.
    Bioorganic & medicinal chemistry, 2011, Feb-15, Volume: 19, Issue:4

    Topics: Animals; Aromatase; Aromatase Inhibitors; Brain; Brain Chemistry; Macaca mulatta; Male; Positron-Emission Tomography; Stereoisomerism; Triazoles

2011
Increase in hypothalamic aromatase in macaque monkeys treated with anabolic-androgenic steroids: PET study with [11C]vorozole.
    Neuroreport, 2011, May-11, Volume: 22, Issue:7

    Topics: Anabolic Agents; Androgens; Animals; Aromatase; Carbon Radioisotopes; Hypothalamus; Macaca mulatta; Male; Positron-Emission Tomography; Triazoles

2011
Aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole and vorozole templates.
    ChemMedChem, 2011, Aug-01, Volume: 6, Issue:8

    Topics: Aromatase; Aromatase Inhibitors; Binding Sites; Catalytic Domain; Cell Line, Tumor; Computer Simulation; Crystallography, X-Ray; Enzyme Activation; Humans; Letrozole; Nitriles; Stereoisomerism; Steryl-Sulfatase; Structure-Activity Relationship; Sulfonic Acids; Triazoles

2011
Endocrine therapy, new biologicals, and new study designs for presurgical studies in breast cancer.
    Journal of the National Cancer Institute. Monographs, 2011, Volume: 2011, Issue:43

    Topics: Anastrozole; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Erlotinib Hydrochloride; Female; Gefitinib; Humans; Ki-67 Antigen; Lapatinib; Molecular Targeted Therapy; Multicenter Studies as Topic; Neoadjuvant Therapy; Nitriles; Predictive Value of Tests; Preoperative Period; Quinazolines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Treatment Outcome; Triazoles

2011
PET of aromatase in gastric parietal cells using 11C-vorozole.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:12

    Topics: Animals; Aromatase; Autoradiography; Carbon Radioisotopes; Fatigue; Female; Immunohistochemistry; Male; Parietal Cells, Gastric; Positron-Emission Tomography; Rats; Rats, Sprague-Dawley; Triazoles; Whole Body Imaging

2011
Distinct neuroendocrine mechanisms control neural activity underlying sex differences in sexual motivation and performance.
    The European journal of neuroscience, 2013, Volume: 37, Issue:5

    Topics: Animals; Appetitive Behavior; Aromatase Inhibitors; Brain; Cloaca; Coturnix; Estrogens; Female; Gene Expression; Neurons; Neurosecretory Systems; Proto-Oncogene Proteins c-fos; Sex Characteristics; Sexual Behavior, Animal; Testosterone; Triazoles

2013
Investigation of the effect of active efflux at the blood-brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system.
    Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:9

    Topics: Anastrozole; Animals; Aromatase; Aromatase Inhibitors; ATP Binding Cassette Transporter, Subfamily B; Blood-Brain Barrier; Brain; Cell Line; Humans; Letrozole; Male; Mice; Nitriles; Triazoles

2013
Quantitative receptor-based imaging of tumor proliferation with the sigma-2 ligand [(18)F]ISO-1.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Apoptosis; Benzamides; Bexarotene; Blotting, Western; Cell Proliferation; Female; Flow Cytometry; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Ligands; Mammary Neoplasms, Animal; Methylnitrosourea; Mice; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Receptors, sigma; Tetrahydronaphthalenes; Triazoles; Tumor Cells, Cultured

2013
11C-cetrozole: an improved C-11C-methylated PET probe for aromatase imaging in the brain.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2014, Volume: 55, Issue:5

    Topics: Aniline Compounds; Animals; Aromatase; Aromatase Inhibitors; Autoradiography; Brain; Carbon Radioisotopes; Female; Inhibitory Concentration 50; Macaca mulatta; Male; Methylation; Positron-Emission Tomography; Protein Binding; Rats; Rats, Sprague-Dawley; Tissue Distribution; Triazoles

2014
Kinetic analysis of [11C]vorozole binding in the human brain with positron emission tomography.
    Molecular imaging, 2014, Volume: 13

    Topics: Adult; Aged; Aromatase Inhibitors; Carbon Radioisotopes; Cerebellum; Female; Humans; Letrozole; Male; Middle Aged; Nitriles; Positron-Emission Tomography; Thalamus; Tissue Distribution; Triazoles; Young Adult

2014
Aromatase imaging with [N-methyl-11C]vorozole PET in healthy men and women.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2015, Volume: 56, Issue:4

    Topics: Adult; Age Factors; Aged; Aromatase; Aromatase Inhibitors; Diagnostic Imaging; Female; Healthy Volunteers; Humans; Letrozole; Liver; Male; Middle Aged; Nitriles; Positron-Emission Tomography; Radiometry; Radiopharmaceuticals; Reproducibility of Results; Sex Factors; Software; Triazoles; Whole-Body Irradiation; Young Adult

2015
Estrogen Receptor β Activation Rapidly Modulates Male Sexual Motivation through the Transactivation of Metabotropic Glutamate Receptor 1a.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015, Sep-23, Volume: 35, Issue:38

    Topics: Analysis of Variance; Animals; Aromatase; Coturnix; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Estrogen Receptor beta; Excitatory Amino Acid Agents; Hormones; Male; Motivation; Nitriles; Propionates; Receptors, Metabotropic Glutamate; Sexual Behavior, Animal; Time Factors; Triazoles

2015
Non-ovarian aromatization is required to activate female sexual motivation in testosterone-treated ovariectomized quail.
    Hormones and behavior, 2016, Volume: 83

    Topics: Animals; Aromatase; Aromatase Inhibitors; Coturnix; Estradiol; Female; Male; Motivation; Ovariectomy; Ovary; Quail; Sexual Behavior, Animal; Testosterone; Triazoles

2016
Daily or weekly dosing with EGFR inhibitors, gefitinib and lapatinib, and AKt inhibitor MK2206 in mammary cancer models.
    Oncology reports, 2018, Volume: 40, Issue:3

    Topics: Animals; Disease Models, Animal; Drug Administration Schedule; ErbB Receptors; Female; Gefitinib; Heterocyclic Compounds, 3-Ring; Lapatinib; Male; Mammary Neoplasms, Experimental; Mice; Mice, Knockout; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Triazoles

2018
Site-specific effects of aromatase inhibition on the activation of male sexual behavior in male Japanese quail (Coturnix japonica).
    Hormones and behavior, 2019, Volume: 108

    Topics: Animals; Appetitive Behavior; Aromatase; Aromatase Inhibitors; Brain Mapping; Consummatory Behavior; Coturnix; Female; Male; Organ Specificity; Preoptic Area; Septal Nuclei; Sex Factors; Sexual Behavior, Animal; Testosterone; Triazoles; Ventromedial Hypothalamic Nucleus

2019
Initial Studies with
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2020, Volume: 61, Issue:6

    Topics: Aged; Aromatase; Breast Neoplasms; Carbon Radioisotopes; Female; Humans; Immunohistochemistry; Middle Aged; Positron-Emission Tomography; Triazoles

2020