vorinostat and laq824
vorinostat has been researched along with laq824 in 16 studies
Research
Studies (16)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Atadja, P; Bair, KW; Bontempo, J; Cesarz, D; Chandramouli, N; Chen, R; Cheung, M; Cornell-Kennon, S; Dean, K; Diamantidis, G; France, D; Green, MA; Howell, KL; Kashi, R; Kwon, P; Lassota, P; Martin, MS; Mou, Y; Perez, LB; Remiszewski, SW; Sambucetti, LC; Sharma, S; Smith, T; Sorensen, E; Taplin, F; Trogani, N; Versace, R; Walker, H; Weltchek-Engler, S; Wood, A; Wu, A | 1 |
| Belvedere, S; Miller, TA; Witter, DJ | 1 |
| Altamura, S; De Francesco, R; Gallinari, P; Jones, P; Lahm, A; Neddermann, P; Rowley, M; Serafini, S; Steinkühler, C | 1 |
| Besterman, JM; Déziel, R; Leit, S; Li, Z; Rahil, J; Smil, DV; Tessier, P; Wahhab, A | 1 |
| Bradner, JE; Grachan, ML; Greenberg, EF; Haggarty, SJ; Mazitschek, R; Warnow, T; West, N | 1 |
| Auzzas, L; Baraldi, A; Battistuzzi, G; Cabri, W; Ciacci, A; Deschênes-Simard, B; Gallo, G; Giannini, G; Hanessian, S; Larsson, A; Matera, R; Pisano, C; Vesci, L | 1 |
| Fang, Q; Feng, C; Gu, G; Hou, J; Li, Z; Liu, P; Shen, J; Shi, Y; Wang, H; Wang, P; Xu, F; Yin, Z | 1 |
| Atadja, P; Cao, X; Chen, CH; Cho, YS; Davis, NR; Eckman, J; Fan, J; Fekete, A; Firestone, B; Flynn, J; Green, J; Growney, JD; Holmqvist, M; Hsu, M; Jansson, D; Jiang, L; Kwon, P; Liu, G; Lombardo, F; Lu, Q; Majumdar, D; Meta, C; Perez, L; Pu, M; Ramsey, T; Remiszewski, S; Shultz, MD; Skolnik, S; Traebert, M; Urban, L; Uttamsingh, V; Wang, P; Whitebread, S; Whitehead, L; Yan-Neale, Y; Yao, YM; Zhou, L | 1 |
| Atadja, P; Bickford, S; Buteau, K; Cao, X; Chen, C; Cho, YS; Davis, N; Fan, J; Holmqvist, M; Hsu, M; Jiang, L; Liu, G; Lu, Q; Patel, C; Selvaraj, M; Shultz, M; Suresh, JR; Urban, L; Wang, P; Whitehead, L; Yan-Neale, Y; Zhang, H; Zhou, L | 1 |
| Cincinelli, R; Cuendet, M; Dallavalle, S; De Cesare, M; Giannini, G; Musso, L; Nurisso, A; Simoes-Pires, C; Zuco, V; Zunino, F; Zwick, V | 1 |
| Melton, L | 1 |
| Aherne, W; Atadja, P; Beloueche-Babari, M; Chung, YL; Griffiths, JR; Jackson, LE; Judson, IR; Kristeleit, R; Leach, MO; Troy, H; Workman, P | 1 |
| Atadja, P; Bhalla, K; Chen, J; Eaton, K; Fernandez, P; Fiskus, W; Herger, B; Joshi, R; Kolhe, R; Lee, P; Mandawat, A; Peiper, S; Rao, R; Wang, Y; Yang, Y | 1 |
| Emanuele, S; Lauricella, M; Tesoriere, G | 1 |
| Steffen, D; Tu, S; Wang, Y; Xiong, M | 1 |
| Ahn, SH; Cha, W; Jeon, EH; Jeong, WJ; Kim, DW; Kim, SD | 1 |
Reviews
2 review(s) available for vorinostat and laq824
| Article | Year |
|---|---|
Histone deacetylase inhibitors.
Topics: Animals; Antineoplastic Agents; Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Humans; Models, Molecular; Sequence Alignment; Structure-Activity Relationship | 2003 |
Histone deacetylase inhibitors: apoptotic effects and clinical implications (Review).
Topics: Antineoplastic Agents; Apoptosis; Chromatin; Depsipeptides; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Models, Biological; Models, Chemical; Neoplasms; Protein Structure, Tertiary; Sulfonamides; Vorinostat | 2008 |
Other Studies
14 other study(ies) available for vorinostat and laq824
| Article | Year |
|---|---|
N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).
Topics: Acetyltransferases; Acrylamides; Animals; Antineoplastic Agents; Body Weight; Cell Division; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Female; Histone Acetyltransferases; Humans; Hydroxamic Acids; Indicators and Reagents; Mice; Mice, Nude; Molecular Conformation; Neoplasm Transplantation; Saccharomyces cerevisiae Proteins | 2003 |
Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.
Topics: Acetylation; Benzamides; Catalysis; Cells, Cultured; Escherichia coli; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Kidney; Molecular Structure; Mutation; Peptides, Cyclic; Pyridines; Pyrimidines; Sulfonamides | 2008 |
Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors.
Topics: Cell Line; Diphenylacetic Acids; Enzyme Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Protein Isoforms; Structure-Activity Relationship; Xanthenes | 2009 |
Chemical phylogenetics of histone deacetylases.
Topics: | 2010 |
Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity.
Topics: Cell Line, Tumor; Drug Design; Histone Deacetylase Inhibitors; Humans; Macrocyclic Compounds; Models, Molecular | 2010 |
Structure-based optimization of click-based histone deacetylase inhibitors.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Proliferation; Click Chemistry; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxamic Acids; Models, Molecular; Neoplasms; Phenylalanine; Protein Binding; Protein Structure, Secondary; Structure-Activity Relationship; Triazoles; Vorinostat | 2011 |
Optimization of the in vitro cardiac safety of hydroxamate-based histone deacetylase inhibitors.
Topics: Acrylamides; Animals; Antineoplastic Agents; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Half-Life; HCT116 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; In Vitro Techniques; Mice; Mice, Nude; Microsomes, Liver; Models, Molecular; Neoplasm Transplantation; Patch-Clamp Techniques; Radioligand Assay; Rats; Rats, Sprague-Dawley; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution; Transplantation, Heterologous | 2011 |
The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Isoindoles; Molecular Structure; Stereoisomerism; Structure-Activity Relationship | 2011 |
Biphenyl-4-yl-acrylohydroxamic acids: Identification of a novel indolyl-substituted HDAC inhibitor with antitumor activity.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Colonic Neoplasms; Drug Screening Assays, Antitumor; HCT116 Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Molecular Docking Simulation; Neoplasms; Structure-Activity Relationship | 2016 |
Bring back the acetyls - a novel anticancer movement.
Topics: Animals; Antineoplastic Agents; Clinical Trials as Topic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Mice; Vorinostat | 2003 |
Noninvasive magnetic resonance spectroscopic pharmacodynamic markers of a novel histone deacetylase inhibitor, LAQ824, in human colon carcinoma cells and xenografts.
Topics: Acetylation; Animals; Biomarkers, Tumor; Blotting, Western; Cell Cycle; Cell Proliferation; Colonic Neoplasms; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; HT29 Cells; Humans; Hydroxamic Acids; Immunoenzyme Techniques; Male; Mice; Mice, Nude; Nuclear Magnetic Resonance, Biomolecular; Phosphorus Isotopes; Phosphorylcholine; Tumor Cells, Cultured; Vorinostat; Xenograft Model Antitumor Assays | 2008 |
Molecular and biologic characterization and drug sensitivity of pan-histone deacetylase inhibitor-resistant acute myeloid leukemia cells.
Topics: Acetylation; Animals; Antineoplastic Agents; Apoptosis; Azacitidine; Benzoquinones; Cell Differentiation; Cell Proliferation; Decitabine; DNA-Binding Proteins; Drug Resistance, Neoplasm; Enzyme Inhibitors; Heat Shock Transcription Factors; Histone Deacetylase Inhibitors; HL-60 Cells; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Hydroxamic Acids; Indoles; Lactams, Macrocyclic; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Neoplasm Proteins; Panobinostat; S Phase; Transcription Factors; Tubulin; Vorinostat | 2008 |
Iron complexation to histone deacetylase inhibitors SAHA and LAQ824 in PEGylated liposomes can considerably improve pharmacokinetics in rats.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Cell Line, Tumor; Drug Liberation; Female; Half-Life; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Iron; Liposomes; Male; Particle Size; Phagocytes; Polyethylene Glycols; Prostatic Neoplasms; Rats; Rats, Sprague-Dawley; Solubility; Vorinostat | 2014 |
Effect of perioperative treatment with a hypoxia-inducible factor-1-alpha inhibitor in an orthotopic surgical mouse model of thyroid cancer.
Topics: Animals; Apoptosis; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Hydroxamic Acids; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Neovascularization, Pathologic; Perioperative Period; Thyroid Neoplasms; Vorinostat | 2015 |