vl-0395 has been researched along with loxiglumide* in 1 studies
1 other study(ies) available for vl-0395 and loxiglumide
Article | Year |
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Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes".
The interaction between the 1-47 N-terminus of the CCK(1)-R and the anthranilic acid based antagonists has been investigated by fluorescence spectroscopy. These antagonists interact with W39 of the N-terminal domain of the CCK(1)-R like that of the endogenous ligand CCK-8. This specific interaction was not found in other nonpeptide ligands of the CCK(1)-R. Conformational studies, using NMR and energy minimization procedures, have allowed formulation of a new hypothesis on the CCK(1)-R binding mode of the anthranilic antagonists. Topics: Animals; Binding, Competitive; Biological Assay; Humans; Indoles; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; ortho-Aminobenzoates; Pancreas; Proglumide; Protein Conformation; Rats; Receptor, Cholecystokinin A; Sincalide; Spectrometry, Fluorescence; Structure-Activity Relationship | 2006 |