vitexin-rhamnoside and ferulic-acid

This study investigated the pharmacokinetics of hesperidin (HP), ferulic acid (FA) and p-coumaric acid (CA) in rat plasma after oral administration of Portulaca oleracea L. extract (POE). The plasma concentrations were determined by HPLC with vitexin-2″-O-rhamnoside (VR) as internal standard. The calibration curves were linear over the range 0.1-5 µg mL(-1), 0.1-5 µg mL(-1)and 0.015-3 µg mL(-1) for HP, FA and CA, respectively. The validated method was suitable to the pharmacokinetic study of HP, FA and CA in rats after oral administration at a single dose of POE.

Topics: Administration, Oral; Animals; Apigenin; Calibration; Chromatography, High Pressure Liquid; Coumaric Acids; Hesperidin; Phenols; Plant Extracts; Portulaca; Propionates; Rats; Reproducibility of Results