Page last updated: 2024-08-26

vitamin k1 oxide and warfarin

vitamin k1 oxide has been researched along with warfarin in 43 studies

Research

Studies (43)

Timeframe	Studies, this research(%)	All Research%
pre-1990	17 (39.53)	18.7374
1990's	9 (20.93)	18.2507
2000's	9 (20.93)	29.6817
2010's	7 (16.28)	24.3611
2020's	1 (2.33)	2.80

Authors

Authors	Studies
Ishibashi, M; Kariyazono, H; Nakamura, K; Shimokawa, S; Taira, A; Toyohira, H	1
Diplock, AT; Ross, PJ; Schey, SA; Shearer, MJ	1
Bélanger, PM; Labrecque, G; Soulban, G	1
Shike, T; Uchida, K; Yamanaka, Y; Yamano, M; Yasunaga, K	1
Canfield, LM; Gunn, JM; Johnson, TM; Martin, GS	1
Park, BK; Pratt, SK; Scott, AK; White, PM; Winn, MJ	1
Hazelett, SE; Lemasters, KK; Preusch, PC	1
Breckenridge, AM; Cholerton, S; Choonara, IA; Haynes, BP; Park, BK	2
Hazelett, SE; Preusch, PC	1
Fasco, MJ; Galivan, JH; Rhee, M; Trivedi, LS	1
Lian, JB; Mosher, DF; Pauli, RM; Suttie, JW	1
Creedon, KA; Suttie, JW	1
Mukharji, I; Silverman, RB	1
Breckenridge, AM; Cholerton, S; Choonara, IA; Haynes, BP; Park, BK; Scott, AK	1
Hart, JA; Haynes, BP; Park, BK	1
Fasco, MJ; Friedman, PA; Principe, LM; Walsh, WA	1
Preusch, PC; Suttie, JW	1
Bell, RG; Ren, P	1
Blaschke, TF; Carlisle, DM	1
Reedstrom, CK; Suttie, JW	1
Ishibashi, M; Kariyazono, H; Nakamura, K; Saigenji, H; Shimokawa, S; Taira, A; Toyohira, H	1
Hallak, HO; Lewis, GL; Modi, MW; Patel, IH; Trowbridge, AA; Wedlund, PJ; Woodruff, B	1
Anderson, SA; Bach, AU; Foley, AL; Suttie, JW; Williams, EC	1
Camilo, ME; Davidson, K; Jatoi, A; Mason, JB; O'Brien, M; Sadowski, JA; Sokoll, L	1
Butler, TJ; Edwards, C; Kamali, F; Wynne, HA	1
Booth, SL; Bovill, EG; Cushman, M; Davidson, KW; Possidente, CJ; Sadowski, JA	1
Begent, LA; Cowell, DC; Hill, AP; Hutt, AJ; Pallister, CJ; Steventon, GB	1
Fregin, A; Krebsova, A; Muller, CR; Oldenburg, J; Rost, S; Wolz, W	1
Carlson, GP; Hooser, SB; Sauer, JM; Wallin, R; Ward, MP; Wilson, CR	1
Bevans, CG; Fregin, A; Hünerberg, M; Müller, CR; Oldenburg, J; Rost, S	1
Chu, PH; Huang, TY; Stafford, DW; Williams, J	1
Jin, DY; Stafford, DW; Tie, JK	1
Stafford, DW; Tie, JK	1
Aarons, L; Gueorguieva, I; Soon, D; Wise, S; Yuen, E	1
Jin, DY; Stafford, DW; Straight, DL; Tie, JK	1
Fujita, S; Harunari, T; Ikenaka, Y; Ishizuka, M; Kawai, YK; Tanaka, KD; Tanikawa, T	1
Bowman, GR; Cui, W; Gross, ML; Huang, W; Li, S; Li, W; Liu, Q; Sadler, JE; Shen, G; Yang, Y; Zhang, H; Zhou, F	1
Biswas, A; Czogalla, KJ; Höning, K; Hornung, V; Liphardt, K; Oldenburg, J; Watzka, M	1
Berkner, KL; Hallgren, KW; Rishavy, MA; Runge, KW; Singh, S; Wilson, L	1
Ferron, M; Lacombe, J	1
Cao, Q; Chen, Y; Gao, M; Li, C; Li, S; Li, W; Liu, H; Megta, AK; Shen, G; Shen, Y; Yu, H	1

Reviews

3 review(s) available for vitamin k1 oxide and warfarin

Article	Year
Conversion of vitamin K epoxide to hydroxyvitamin K by liver microsomes from warfarin-resistant rats. Nutrition reviews, 1983, Volume: 41, Issue:8 Topics: Animals; Drug Resistance; Microsomes, Liver; Mixed Function Oxygenases; Rats; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1983
Structure and function of vitamin K epoxide reductase. Vitamins and hormones, 2008, Volume: 78 Topics: Animals; Binding Sites; Enzyme Inhibitors; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2008
VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and Extrahepatic Tissues. Nutrients, 2018, Jul-26, Volume: 10, Issue:8 Topics: Animals; Anticoagulants; Blood Coagulation; Carboxylic Acids; Evolution, Molecular; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Humans; Liver; Oxidation-Reduction; Protein Conformation; Protein Processing, Post-Translational; Structure-Activity Relationship; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2018

Trials

3 trial(s) available for vitamin k1 oxide and warfarin

Article	Year
Stereoselective interaction between the R enantiomer of warfarin and cimetidine. British journal of clinical pharmacology, 1986, Volume: 21, Issue:3 Topics: Administration, Oral; Bradycardia; Cimetidine; Drug Eruptions; Drug Interactions; Half-Life; Humans; Hypotension; Injections, Intravenous; Kinetics; Protein Binding; Prothrombin Time; Random Allocation; Stereoisomerism; Vitamin K 1; Warfarin	1986
Anticoagulant effects of warfarin and kinetics of K vitamins in blood and feces. Artery, 1994, Volume: 21, Issue:3 Topics: Adult; Aged; Biomarkers; Blood Coagulation; Blood Coagulation Factors; Feces; Female; Humans; Male; Middle Aged; Protein Precursors; Prothrombin; Vitamin K; Vitamin K 1; Vitamin K 2; Warfarin	1994
Bioavailability of phylloquinone from an intravenous lipid emulsion. The American journal of clinical nutrition, 1998, Volume: 67, Issue:4 Topics: Adult; Biological Availability; Biomarkers; Diet; Fat Emulsions, Intravenous; Female; Humans; Male; Osteocalcin; Protein Precursors; Prothrombin; Vitamin K 1; Vitamin K Deficiency; Warfarin	1998

Other Studies

37 other study(ies) available for vitamin k1 oxide and warfarin

Article	Year
Variations in warfarin concentration in blood and coagulant factors after artificial valve replacement. Artery, 1992, Volume: 19, Issue:6 Topics: Aged; Biomarkers; Blood Coagulation Factors; Cyanoacrylates; Female; Heart Valve Prosthesis; Humans; Male; Middle Aged; Osteocalcin; Protein Precursors; Prothrombin; Prothrombin Time; Tissue Adhesives; Vitamin K 1; Warfarin	1992
A fibroblast cell culture model to study vitamin K metabolism and the inhibition of vitamin K epoxide reductase by known and suspected antagonists. British journal of haematology, 1991, Volume: 77, Issue:2 Topics: Animals; Cells, Cultured; Fibroblasts; Mice; Mixed Function Oxygenases; Models, Biological; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1991
Temporal variation in the effects of warfarin on the vitamin K cycle. Chronobiology international, 1990, Volume: 7, Issue:5-6 Topics: Administration, Oral; Animals; Circadian Rhythm; Drug Administration Schedule; Liver; Male; Mixed Function Oxygenases; Quinone Reductases; Rats; Rats, Inbred Strains; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1990
Effect of warfarin on plasma and liver vitamin K levels and vitamin K epoxide reductase activity in relation to plasma clotting factor levels in rats. Thrombosis research, 1990, Jan-15, Volume: 57, Issue:2 Topics: Animals; Factor VII; Liver; Male; Mixed Function Oxygenases; Prothrombin; Rats; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1990
Absorption and metabolism of vitamin K in Swiss 3T3 mouse fibroblasts--a model system for study of vitamin K absorption and metabolism. Biochemical and biophysical research communications, 1987, Sep-15, Volume: 147, Issue:2 Topics: 1-Carboxyglutamic Acid; Absorption; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Dicumarol; Fibroblasts; Mass Spectrometry; Mice; Models, Biological; Vitamin K; Vitamin K 1; Warfarin	1987
The bioavailability of a mixed micellar preparation of vitamin K1, and its procoagulant effect in anticoagulated rabbits. The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:4 Topics: 4-Hydroxycoumarins; Animals; Anticoagulants; Biological Availability; Blood Coagulation; Coumarins; Half-Life; In Vitro Techniques; Male; Micelles; Rabbits; Vitamin K 1	1989
Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase. Archives of biochemistry and biophysics, 1989, Feb-15, Volume: 269, Issue:1 Topics: Animals; Drug Resistance; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Quinone Reductases; Rats; Structure-Activity Relationship; Sulfanilamides; Sulfaquinoxaline; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1989
Tissue distribution and warfarin sensitivity of vitamin K epoxide reductase. Biochemical pharmacology, 1988, Mar-01, Volume: 37, Issue:5 Topics: Animals; Dithiothreitol; Kinetics; Microsomes; Mixed Function Oxygenases; Rats; Substrate Specificity; Tissue Distribution; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1988
Normal and warfarin-resistant rat hepatocyte metabolism of vitamin K 2,3-epoxide: evidence for multiple pathways of hydroxyvitamin K formation. Archives of biochemistry and biophysics, 1988, Volume: 264, Issue:1 Topics: Animals; Cells, Cultured; Dithiothreitol; Drug Resistance; Liver; Male; Rats; Rats, Inbred Strains; Vitamin K; Vitamin K 1; Warfarin	1988
Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of teratogenicity of coumarin derivatives. American journal of human genetics, 1987, Volume: 41, Issue:4 Topics: 1-Carboxyglutamic Acid; Abnormalities, Drug-Induced; Calcium-Binding Proteins; Child; Chromatography, High Pressure Liquid; Female; Fetal Diseases; Fingers; Humans; Male; Nose; Osteocalcin; Phenotype; Pregnancy; Prothrombin; Radiography; Vitamin K; Vitamin K 1; Vitamin K Deficiency; Warfarin	1987
Enantiomers of warfarin and vitamin K1 metabolism. British journal of clinical pharmacology, 1986, Volume: 22, Issue:6 Topics: Half-Life; Humans; Prothrombin Time; Stereoisomerism; Vitamin K 1; Warfarin	1986
Effect of N-methyl-thiotetrazole on vitamin K epoxide reductase. Thrombosis research, 1986, Oct-15, Volume: 44, Issue:2 Topics: Animals; Azoles; Coumarins; Cytosol; Dithiothreitol; Hypoprothrombinemias; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Tetrazoles; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1986
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:9 Topics: Animals; Cattle; Dithiothreitol; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Protein Conformation; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1985
Vitamin K1 metabolism in relation to pharmacodynamic response in anticoagulated patients. British journal of clinical pharmacology, 1985, Volume: 20, Issue:6 Topics: Adult; Aged; Anticoagulants; Blood Coagulation Tests; Female; Half-Life; Humans; Male; Middle Aged; Prothrombin Time; Vitamin K; Vitamin K 1; Warfarin	1985
A study of factors which determine the pharmacological response to vitamin K in coumarin anticoagulated rabbits. Biochemical pharmacology, 1984, Oct-01, Volume: 33, Issue:19 Topics: Animals; Blood Coagulation Factors; Coumarins; Male; Prothrombin; Rabbits; Vitamin K; Vitamin K 1	1984
Warfarin inhibition of vitamin K 2,3-epoxide reductase in rat liver microsomes. Biochemistry, 1983, Nov-22, Volume: 22, Issue:24 Topics: Animals; Chemical Phenomena; Chemistry; Dithiothreitol; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1983
Formation of 3-hydroxy-2,3-dihydrovitamin K1 in vivo: relationship to vitamin K epoxide reductase and warfarin resistance. The Journal of nutrition, 1984, Volume: 114, Issue:5 Topics: Animals; Chromatography, High Pressure Liquid; Drug Resistance; Liver; Male; Mixed Function Oxygenases; Rats; Vitamin K; Vitamin K 1; Vitamin K Deficiency; Vitamin K Epoxide Reductases; Warfarin	1984
Inhibition by warfarin enantiomers of prothrombin synthesis, protein carboxylation, and the regeneration of vitamin K from vitamin K epoxide. Biochemical pharmacology, 1981, Jul-15, Volume: 30, Issue:14 Topics: Animals; Chemistry, Organic; Depression, Chemical; Epoxy Compounds; In Vitro Techniques; Liver; Organic Chemistry Phenomena; Proteins; Prothrombin; Rats; Stereoisomerism; Vitamin K; Vitamin K 1; Warfarin	1981
Vitamin K1, vitamin K1 epoxide and warfarin interrelationships in the dog. Biochemical pharmacology, 1981, Nov-01, Volume: 30, Issue:21 Topics: Animals; Chemical Phenomena; Chemistry; Dogs; Epoxy Compounds; Male; Time Factors; Vitamin K 1; Warfarin	1981
Comparative distribution, metabolism, and utilization of phylloquinone and menaquinone-9 in rat liver. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1995, Volume: 209, Issue:4 Topics: Animals; Carbon-Carbon Ligases; Diet; Ligases; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Vitamin K; Vitamin K 1; Vitamin K 2; Warfarin	1995
High clearance of (S)-warfarin in a warfarin-resistant subject. British journal of clinical pharmacology, 1993, Volume: 35, Issue:3 Topics: Adult; Blood Coagulation; Drug Resistance; Female; Humans; Male; Stereoisomerism; Vitamin K; Vitamin K 1; Warfarin	1993
Assessment of vitamin K status in human subjects administered "minidose" warfarin. The American journal of clinical nutrition, 1996, Volume: 64, Issue:6 Topics: 1-Carboxyglutamic Acid; Adult; Aged; Anticoagulants; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Incidence; Male; Middle Aged; Osteocalcin; Prothrombin; Thrombosis; Vitamin K; Vitamin K 1; Warfarin	1996
The influence of (R)- and (S)-warfarin, vitamin K and vitamin K epoxide upon warfarin anticoagulation. Thrombosis and haemostasis, 2000, Volume: 84, Issue:1 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Blood Coagulation; Blood Coagulation Factors; Drug Resistance; Female; Genetic Variation; Humans; International Normalized Ratio; Liver; Male; Middle Aged; Multivariate Analysis; Stereoisomerism; Vitamin K; Vitamin K 1; Warfarin	2000
The association of vitamin K status with warfarin sensitivity at the onset of treatment. British journal of haematology, 2001, Volume: 112, Issue:3 Topics: Aged; Anticoagulants; Biomarkers; Female; Humans; International Normalized Ratio; Linear Models; Male; Middle Aged; Nutritional Status; Preoperative Care; Protein Precursors; Prothrombin; Treatment Outcome; Triglycerides; Vitamin K; Vitamin K 1; Warfarin	2001
Characterization and purification of the vitamin K1 2,3 epoxide reductases system from rat liver. The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:4 Topics: Animals; Benzoquinones; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Endoplasmic Reticulum; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Rats; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2001
Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16. Blood, 2002, Nov-01, Volume: 100, Issue:9 Topics: Animals; Blood Coagulation Factors; Centromere; Child; Chromosome Mapping; Chromosomes, Human, Pair 16; DNA Mutational Analysis; Drug Resistance; Female; Genes, Recessive; Genetic Markers; Genotype; Germany; Glutathione Transferase; Hemorrhagic Disorders; Humans; Infant, Newborn; Lebanon; Lod Score; Male; Mice; Microsatellite Repeats; Mixed Function Oxygenases; Multienzyme Complexes; Pedigree; Rats; Species Specificity; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2002
Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition. Toxicology, 2003, Aug-01, Volume: 189, Issue:3 Topics: Animals; Anticoagulants; Cattle; Dogs; Female; Horses; Humans; Inhibitory Concentration 50; Kinetics; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases; Rats; Sheep; Species Specificity; Swine; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2003
Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin. Thrombosis and haemostasis, 2005, Volume: 94, Issue:4 Topics: Amino Acid Sequence; Anticoagulants; Binding Sites; Cell Line; Coumarins; Disulfides; Drug Resistance; Humans; Hydrophobic and Hydrophilic Interactions; Kidney; Mixed Function Oxygenases; Molecular Sequence Data; Mutagenesis, Site-Directed; Vitamin K 1; Vitamin K Epoxide Reductases	2005
Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2. Proceedings of the National Academy of Sciences of the United States of America, 2006, Dec-19, Volume: 103, Issue:51 Topics: Baculoviridae; Genetic Vectors; Humans; Mixed Function Oxygenases; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2006
The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines. Biochemistry, 2007, Jun-19, Volume: 46, Issue:24 Topics: Amino Acid Substitution; Catalytic Domain; Cysteine; Disulfides; Enzyme Inhibitors; Kinetics; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Vitamin K 1; Vitamin K 2; Vitamin K Epoxide Reductases; Warfarin	2007
Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin. Journal of pharmacokinetics and pharmacodynamics, 2010, Volume: 37, Issue:1 Topics: Adult; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Asian People; Bayes Theorem; Computer Simulation; Cytochrome P-450 CYP2C9; Fibrinolytic Agents; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Nonlinear Dynamics; Polymorphism, Genetic; Retrospective Studies; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2010
Functional study of the vitamin K cycle in mammalian cells. Blood, 2011, Mar-10, Volume: 117, Issue:10 Topics: Anticoagulants; Cell Line; Clinical Laboratory Techniques; HEK293 Cells; Humans; Mixed Function Oxygenases; Signal Transduction; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2011
A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats. The Journal of veterinary medical science, 2013, Volume: 75, Issue:2 Topics: Animals; Female; Gene Expression Regulation, Enzymologic; Japan; Male; Metabolism, Inborn Errors; Mixed Function Oxygenases; Mutation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rodenticides; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2013
Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer. Nature structural & molecular biology, 2017, Volume: 24, Issue:1 Topics: Biocatalysis; Catalytic Domain; HEK293 Cells; Humans; Molecular Docking Simulation; Oxidation-Reduction; Protein Binding; Vitamin K 1; Vitamin K 2; Vitamin K Epoxide Reductases; Warfarin	2017
Warfarin and vitamin K compete for binding to Phe55 in human VKOR. Nature structural & molecular biology, 2017, Volume: 24, Issue:1 Topics: Biocatalysis; Catalytic Domain; Drug Resistance; HEK293 Cells; Humans; Molecular Docking Simulation; Oxidation-Reduction; Phenylalanine; Protein Binding; Protein Conformation, alpha-Helical; Vitamin K 1; Vitamin K 2; Vitamin K Epoxide Reductases; Warfarin	2017
Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase. Blood, 2018, 06-21, Volume: 131, Issue:25 Topics: Animals; Anticoagulants; Cell Line; Cricetinae; Drug Resistance; Humans; Oxidation-Reduction; Point Mutation; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2018
Structural features determining the vitamin K epoxide reduction activity in the VKOR family of membrane oxidoreductases. The FEBS journal, 2022, Volume: 289, Issue:15 Topics: Epoxy Compounds; Humans; Oxidoreductases; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2022