Page last updated: 2024-08-26

vitamin k1 oxide and vitamin k 1

vitamin k1 oxide has been researched along with vitamin k 1 in 107 studies

Research

Studies (107)

Timeframe	Studies, this research(%)	All Research%
pre-1990	49 (45.79)	18.7374
1990's	28 (26.17)	18.2507
2000's	14 (13.08)	29.6817
2010's	14 (13.08)	24.3611
2020's	2 (1.87)	2.80

Authors

Authors	Studies
Bell, RG	1
Preusch, PC	1
Ishibashi, M; Kariyazono, H; Nakamura, K; Shimokawa, S; Taira, A; Toyohira, H	1
Furie, B; Furie, BC; Hubbard, BR; Koski, IJ; Kuliopulos, A; Lam, Z; Walsh, CT	1
Frederich, A; Guillaumont, M; Leclercq, M; Sann, L; Vignal, B; Weiser, H	1
Hallak, HO; Wedlund, PJ	1
Matthias, FR; Schäfer, H	1
Lipsky, JJ; Mallat, A; Mitchell, MC	1
Diplock, AT; Ross, PJ; Schey, SA; Shearer, MJ	1
Bélanger, PM; Labrecque, G; Soulban, G	1
Preusch, PC; Smalley, DM	1
Brenner, B; Keller, CB; Seligsohn, U; Suttie, JW; Tatarsky, I; Tavori, S; Zivelin, A	1
Shike, T; Uchida, K; Yamanaka, Y; Yamano, M; Yasunaga, K	1
Nandi, DL; Ryall, RP; Silverman, RB	1
Gardill, SL; Suttie, JW	1
Bechtold, H; Jähnchen, E; Nies, B; Trenk, D; Wagner, F	1
Canfield, LM; Gunn, JM; Johnson, TM; Martin, GS	1
Park, BK; Pratt, SK; Scott, AK; White, PM; Winn, MJ	1
Light, RJ; Priest, JW	1
Aymard, P; Didry, JR; Dufour, L; Moussa, F	1
Kass, PH; Mount, ME	1
Suttie, JW; Wood, GM	1
Inyangetor, PT; Thierry-Palmer, M	1
Uotila, L	1
Hirauchi, K; Morimoto, A; Nagaoka, T; Sakano, T	1
Hazelett, SE; Lemasters, KK; Preusch, PC	1
Breckenridge, AM; Cholerton, S; Choonara, IA; Haynes, BP; Park, BK	2
Hazelett, SE; Preusch, PC	1
Andrassy, K; Bechtold, H; Jähnchen, E; Koderisch, J; McCarthy, PT; Ritz, E; Shearer, MJ; Trenk, D	1
Fasco, MJ; Galivan, JH; Rhee, M; Trivedi, LS	1
Martin, LF; Patrick, SD; Wallin, R	1
Lian, JB; Mosher, DF; Pauli, RM; Suttie, JW	1
Bacon, DS; Haroon, Y; Sadowski, JA	1
Creedon, KA; Suttie, JW	1
Mukharji, I; Silverman, RB	1
Breckenridge, AM; Choonara, IA; Haynes, BP; Malia, RG; Park, BK; Preston, FE	1
Hathaway, WE; Lane, PA	1
Dose, K; Guenthner, T; Liptay-Reuter, I; Oesch, F; Wörner, W	1
Bethenod, M; Bourgeay-Causse, M; Bourgeois, J; Frederich, A; Leclercq, M; Sann, L	1
Breckenridge, AM; Cholerton, S; Choonara, IA; Haynes, BP; Park, BK; Scott, AK	1
Bechtold, H; Jähnchen, E; Meinertz, T; Trenk, D	1
Hildebrandt, EF; Suttie, JW	1
Hildebrandt, E; Suttie, JW	1
Olson, RE	1
Hart, JA; Haynes, BP; Park, BK	1
Andrassy, K; Bechtold, H; Jähnchen, E; Koderisch, H; Koderisch, J; Ritz, E; Sonntag, HG; Weilemann, LS	1
Park, BK; Wilson, AC	2
Fasco, MJ; Friedman, PA; Principe, LM; Walsh, WA	1
Bechtold, H; Jähnchen, E; Meinertz, T; Rowland, M; Trenk, D	1
Bechtold, H; Jähnchen, E; Klein, F; Trenk, D	1
Preusch, PC; Suttie, JW	1
Fasco, MJ; Lee, JJ	1
Langenberg, JP; Tjaden, UR	1
Bell, RG; Ren, P	1
Blaschke, TF; Carlisle, DM	1
Hiraga, K; Takahashi, O	1
Sander, EG; Sherman, PA	1
Elliott, GR; Odam, EM; Townsend, MG	1
Belghiti, J; Bezeaud, A; Flejou, JF; Guillin, MC; Huisse, MG; Leclercq, M; Stafford, DW; Suttie, JW	1
Dowd, P; Ham, SW; Hershline, R; Naganathan, S	1
Reedstrom, CK; Suttie, JW	1
Ishibashi, M; Kariyazono, H; Nakamura, K; Saigenji, H; Shimokawa, S; Taira, A; Toyohira, H	1
Bhushan, F; Bovill, EG; Church, W; Davidson, K; Freije, M; Landesman, M; Lynch, M; McAuliffe, T; Sadowski, J; Soll, RF	1
Dostalova, L; Frederich, A; Guillaumont, M; Leclercq, M; Sann, L; Vignal, B	1
Hallak, HO; Lewis, GL; Modi, MW; Patel, IH; Trowbridge, AA; Wedlund, PJ; Woodruff, B	1
Anderson, SA; Bach, AU; Foley, AL; Suttie, JW; Williams, EC	1
Ronden, JE; Saupe, J; Soute, BA; Thijssen, HH; Vermeer, C	1
Ahrens, RA; Beker, LT; Davidson, KW; Fink, RJ; O'Brien, ME; Sadowski, JA; Sokoll, LJ	1
Davidson, KW; Sadowski, JA	1
Usui, Y	1
Camilo, ME; Davidson, K; Jatoi, A; Mason, JB; O'Brien, M; Sadowski, JA; Sokoll, L	1
Butler, TJ; Edwards, C; Kamali, F; Wynne, HA	1
Booth, SL; Bovill, EG; Cushman, M; Davidson, KW; Possidente, CJ; Sadowski, JA	1
Begent, LA; Cowell, DC; Hill, AP; Hutt, AJ; Pallister, CJ; Steventon, GB	1
Ghosh, K; Mohanty, D; Shetty, S	1
Fregin, A; Krebsova, A; Muller, CR; Oldenburg, J; Rost, S; Wolz, W	1
Carlson, GP; Hooser, SB; Sauer, JM; Wallin, R; Ward, MP; Wilson, CR	1
Bevans, CG; Fregin, A; Hünerberg, M; Müller, CR; Oldenburg, J; Rost, S	1
Hutson, SM; Wajih, N; Wallin, R	1
Chu, PH; Huang, TY; Stafford, DW; Williams, J	1
Jin, DY; Stafford, DW; Tie, JK	1
BENNETT, IL; JAMES, DF	2
Stafford, DW; Tie, JK	2
Berkner, KL	1
BUTLER, JJ; JAMES, DF	1
Hannestad, U; Osman, A	1
Bhatia, AC; Cohen, JL	1
Aarons, L; Gueorguieva, I; Soon, D; Wise, S; Yuen, E	1
Berkner, KL; Hallgren, KW; Rishavy, MA; Usubalieva, A	1
Jin, DY; Stafford, DW; Straight, DL; Tie, JK	1
Fujita, S; Harunari, T; Ikenaka, Y; Ishizuka, M; Kawai, YK; Tanaka, KD; Tanikawa, T	1
Newman, P; Shearer, MJ	1
Bellante, S; Cafolla, A; Caretti, F; Curini, R; Fernández, VP; Gasperi, T; Gentili, A	1
Bowman, GR; Cui, W; Gross, ML; Huang, W; Li, S; Li, W; Liu, Q; Sadler, JE; Shen, G; Yang, Y; Zhang, H; Zhou, F	1
Biswas, A; Czogalla, KJ; Höning, K; Hornung, V; Liphardt, K; Oldenburg, J; Watzka, M	1
De Eusebio-Murillo, E; Gatica-Ortega, ME; González-Muñoz, P; Melgar-Molero, V; Mollejo, M; Pastor-Nieto, MA; Schoendorff, C	1
Ardell, S; Offringa, M; Ovelman, C; Soll, R	1
Berkner, KL; Hallgren, KW; Rishavy, MA; Runge, KW; Singh, S; Wilson, L	1
Ferron, M; Lacombe, J	1
Ochando-Ibernón, G; Schneller-Pavelescu, L; Silvestre-Salvador, JF; Vergara-de Caso, E	1
Abi Khalil, R; Benoit, E; Chatron, N; Lattard, V	1
Cao, Q; Chen, Y; Gao, M; Li, C; Li, S; Li, W; Liu, H; Megta, AK; Shen, G; Shen, Y; Yu, H	1

Reviews

9 review(s) available for vitamin k1 oxide and vitamin k 1

Article	Year
Metabolism of vitamin K and prothrombin synthesis: anticoagulants and the vitamin K--epoxide cycle. Federation proceedings, 1978, Volume: 37, Issue:12 Topics: 1-Carboxyglutamic Acid; Animals; Anticoagulants; Cricetinae; Drug Resistance; Endoplasmic Reticulum; Epoxy Compounds; Humans; Liver; Mitochondria, Liver; Oxidoreductases; Prothrombin; Rats; Vitamin K; Vitamin K 1	1978
Conversion of vitamin K epoxide to hydroxyvitamin K by liver microsomes from warfarin-resistant rats. Nutrition reviews, 1983, Volume: 41, Issue:8 Topics: Animals; Drug Resistance; Microsomes, Liver; Mixed Function Oxygenases; Rats; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1983
The function and metabolism of vitamin K. Annual review of nutrition, 1984, Volume: 4 Topics: 4-Hydroxycoumarins; Amino Acid Sequence; Animals; Carbon-Carbon Ligases; DNA; DNA, Recombinant; Electron Transport; Genetic Variation; Humans; Immunologic Techniques; Intestinal Absorption; Kinetics; Ligases; Microsomes, Liver; Mixed Function Oxygenases; Nutritional Requirements; Peptides; Protein Binding; Protein Precursors; Protein Sorting Signals; Prothrombin; Quinone Reductases; RNA, Messenger; Salicylates; Tissue Distribution; Vitamin A; Vitamin E; Vitamin K; Vitamin K 1; Vitamin K Deficiency; Vitamin K Epoxide Reductases	1984
Vitamin K and energy transduction: a base strength amplification mechanism. Science (New York, N.Y.), 1995, Sep-22, Volume: 269, Issue:5231 Topics: 1-Carboxyglutamic Acid; Animals; Binding Sites; Blood Coagulation Factors; Calcium; Carbon-Carbon Ligases; Cyanides; Energy Metabolism; Hydrogen-Ion Concentration; Ligases; Molecular Conformation; Oxidation-Reduction; Oxygen; Thermodynamics; Vitamin K; Vitamin K 1	1995
Structure and function of vitamin K epoxide reductase. Vitamins and hormones, 2008, Volume: 78 Topics: Animals; Binding Sites; Enzyme Inhibitors; Humans; Mixed Function Oxygenases; Oxidation-Reduction; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2008
Vitamin K-dependent carboxylation. Vitamins and hormones, 2008, Volume: 78 Topics: Animals; Carbon-Carbon Ligases; Cells, Cultured; Humans; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Vitamin K; Vitamin K 1	2008
Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis. Journal of lipid research, 2014, Volume: 55, Issue:3 Topics: Animals; Biosynthetic Pathways; Diet; Dimethylallyltranstransferase; Humans; Intestinal Mucosa; Molecular Structure; Vitamin K 1; Vitamin K 2; Vitamin K Epoxide Reductases	2014
Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates. The Cochrane database of systematic reviews, 2018, 02-05, Volume: 2 Topics: Biomarkers; Humans; Infant; Infant Mortality; Infant, Newborn; Infant, Premature; Injections, Intramuscular; Injections, Intravenous; Liver; Protein Precursors; Prothrombin; Vitamin K; Vitamin K 1; Vitamin K Deficiency Bleeding; Vitamins	2018
VKORC1L1, An Enzyme Mediating the Effect of Vitamin K in Liver and Extrahepatic Tissues. Nutrients, 2018, Jul-26, Volume: 10, Issue:8 Topics: Animals; Anticoagulants; Blood Coagulation; Carboxylic Acids; Evolution, Molecular; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Humans; Liver; Oxidation-Reduction; Protein Conformation; Protein Processing, Post-Translational; Structure-Activity Relationship; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2018

Trials

6 trial(s) available for vitamin k1 oxide and vitamin k 1

Article	Year
Relationship between vitamin K1 2,3-epoxide and vitamin K1 in patients treated with N-methyl-thiotetrazole cephalosporins. Thrombosis research, 1992, Feb-01, Volume: 65, Issue:3 Topics: Cefoperazone; Cefotaxime; Humans; Middle Aged; Moxalactam; Urinary Tract Infections; Vitamin K 1	1992
Stereoselective interaction between the R enantiomer of warfarin and cimetidine. British journal of clinical pharmacology, 1986, Volume: 21, Issue:3 Topics: Administration, Oral; Bradycardia; Cimetidine; Drug Eruptions; Drug Interactions; Half-Life; Humans; Hypotension; Injections, Intravenous; Kinetics; Protein Binding; Prothrombin Time; Random Allocation; Stereoisomerism; Vitamin K 1; Warfarin	1986
Anticoagulant effects of warfarin and kinetics of K vitamins in blood and feces. Artery, 1994, Volume: 21, Issue:3 Topics: Adult; Aged; Biomarkers; Blood Coagulation; Blood Coagulation Factors; Feces; Female; Humans; Male; Middle Aged; Protein Precursors; Prothrombin; Vitamin K; Vitamin K 1; Vitamin K 2; Warfarin	1994
Effect of vitamin K1 supplementation on vitamin K status in cystic fibrosis patients. Journal of pediatric gastroenterology and nutrition, 1997, Volume: 24, Issue:5 Topics: 1-Carboxyglutamic Acid; Administration, Oral; Adolescent; Adult; Biomarkers; Creatinine; Cross-Over Studies; Cystic Fibrosis; Diet Records; Female; Humans; Male; Osteocalcin; Prospective Studies; Protein Precursors; Prothrombin; Vitamin K 1	1997
Bioavailability of phylloquinone from an intravenous lipid emulsion. The American journal of clinical nutrition, 1998, Volume: 67, Issue:4 Topics: Adult; Biological Availability; Biomarkers; Diet; Fat Emulsions, Intravenous; Female; Humans; Male; Osteocalcin; Protein Precursors; Prothrombin; Vitamin K 1; Vitamin K Deficiency; Warfarin	1998
The role of topical vitamin K oxide gel in the resolution of postprocedural purpura. Journal of drugs in dermatology : JDD, 2009, Volume: 8, Issue:11 Topics: Administration, Cutaneous; Aged; Double-Blind Method; Face; Female; Gels; Humans; Lasers, Dye; Male; Middle Aged; Purpura; Telangiectasis; Time Factors; Treatment Outcome; Vitamin K 1	2009

Other Studies

92 other study(ies) available for vitamin k1 oxide and vitamin k 1

Article	Year
Is thioredoxin the physiological vitamin K epoxide reducing agent? FEBS letters, 1992, Jul-06, Volume: 305, Issue:3 Topics: Animals; Cytosol; Goats; Immune Sera; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Rats; Thioredoxin-Disulfide Reductase; Thioredoxins; Vitamin K 1; Vitamin K Epoxide Reductases	1992
Variations in warfarin concentration in blood and coagulant factors after artificial valve replacement. Artery, 1992, Volume: 19, Issue:6 Topics: Aged; Biomarkers; Blood Coagulation Factors; Cyanoacrylates; Female; Heart Valve Prosthesis; Humans; Male; Middle Aged; Osteocalcin; Protein Precursors; Prothrombin; Prothrombin Time; Tissue Adhesives; Vitamin K 1; Warfarin	1992
Dioxygen transfer during vitamin K dependent carboxylase catalysis. Biochemistry, 1992, Aug-25, Volume: 31, Issue:33 Topics: Animals; Carbon-Carbon Ligases; Cattle; Isotope Labeling; Ligases; Mass Spectrometry; Microsomes, Liver; Oxygen; Oxygen Isotopes; Vitamin K 1	1992
Hepatic concentration of vitamin K active compounds after application of phylloquinone to chickens on a vitamin K deficient or adequate diet. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1992, Volume: 62, Issue:1 Topics: Animals; Chickens; Diet; Female; Injections, Intravenous; Liver; Vitamin K; Vitamin K 1; Vitamin K 2; Vitamin K Deficiency	1992
Reversible metabolism of vitamin K-vitamin K epoxide: modeling considerations and limitations. Journal of pharmacokinetics and biopharmaceutics, 1992, Volume: 20, Issue:1 Topics: Animals; Computer Simulation; Dogs; Humans; Mathematical Computing; Models, Biological; Vitamin K; Vitamin K 1	1992
Cephalosporin-induced alteration in hepatic glutathione redox state. A potential mechanism for inhibition of hepatic reduction of vitamin K1,2,3-epoxide in the rat. The Journal of clinical investigation, 1990, Volume: 86, Issue:5 Topics: Animals; Cephalosporins; Dithiothreitol; Glutamates; Glutamic Acid; Glutathione; Liver; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Vitamin K 1	1990
A fibroblast cell culture model to study vitamin K metabolism and the inhibition of vitamin K epoxide reductase by known and suspected antagonists. British journal of haematology, 1991, Volume: 77, Issue:2 Topics: Animals; Cells, Cultured; Fibroblasts; Mice; Mixed Function Oxygenases; Models, Biological; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1991
Temporal variation in the effects of warfarin on the vitamin K cycle. Chronobiology international, 1990, Volume: 7, Issue:5-6 Topics: Administration, Oral; Animals; Circadian Rhythm; Drug Administration Schedule; Liver; Male; Mixed Function Oxygenases; Quinone Reductases; Rats; Rats, Inbred Strains; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1990
Vitamin K1 2,3-epoxide and quinone reduction: mechanism and inhibition. Free radical research communications, 1990, Volume: 8, Issue:4-6 Topics: Animals; Borohydrides; Cytosol; Dithiothreitol; Hydroquinones; In Vitro Techniques; Microsomes, Liver; NAD(P)H Dehydrogenase (Quinone); NADP; Oxidation-Reduction; Quinone Reductases; Quinones; Rats; Vitamin K 1	1990
Hereditary deficiency of all vitamin K-dependent procoagulants and anticoagulants. British journal of haematology, 1990, Volume: 75, Issue:4 Topics: Blood Coagulation Disorders; Child; Factor VII Deficiency; Factor X Deficiency; Female; Glycoproteins; Hemophilia B; Hemorrhagic Disorders; Humans; Hypoprothrombinemias; Male; Pedigree; Protein C Deficiency; Protein S; Vitamin K; Vitamin K 1	1990
Effect of warfarin on plasma and liver vitamin K levels and vitamin K epoxide reductase activity in relation to plasma clotting factor levels in rats. Thrombosis research, 1990, Jan-15, Volume: 57, Issue:2 Topics: Animals; Factor VII; Liver; Male; Mixed Function Oxygenases; Prothrombin; Rats; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1990
Substituted vitamin K epoxide analogues. New competitive inhibitors and substrates of vitamin K1 epoxide reductase. Journal of medicinal chemistry, 1990, Volume: 33, Issue:6 Topics: Animals; Cattle; Microsomes, Liver; Mixed Function Oxygenases; Vitamin K 1; Vitamin K Epoxide Reductases	1990
Vitamin K epoxide and quinone reductase activities. Evidence for reduction by a common enzyme. Biochemical pharmacology, 1990, Sep-01, Volume: 40, Issue:5 Topics: Animals; Chromatography, High Pressure Liquid; Kinetics; Microsomes, Liver; Oxidation-Reduction; Quinone Reductases; Quinones; Rats; Rats, Inbred Strains; Substrate Specificity; Thioredoxins; Vitamin K; Vitamin K 1	1990
Lack of effect of cefixime on the metabolism of vitamin K1. Journal of clinical pharmacology, 1990, Volume: 30, Issue:8 Topics: Administration, Oral; Adult; Cefixime; Cefotaxime; Drug Administration Schedule; Humans; Male; Premedication; Vitamin K; Vitamin K 1	1990
Absorption and metabolism of vitamin K in Swiss 3T3 mouse fibroblasts--a model system for study of vitamin K absorption and metabolism. Biochemical and biophysical research communications, 1987, Sep-15, Volume: 147, Issue:2 Topics: 1-Carboxyglutamic Acid; Absorption; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Dicumarol; Fibroblasts; Mass Spectrometry; Mice; Models, Biological; Vitamin K; Vitamin K 1; Warfarin	1987
The bioavailability of a mixed micellar preparation of vitamin K1, and its procoagulant effect in anticoagulated rabbits. The Journal of pharmacy and pharmacology, 1989, Volume: 41, Issue:4 Topics: 4-Hydroxycoumarins; Animals; Anticoagulants; Biological Availability; Blood Coagulation; Coumarins; Half-Life; In Vitro Techniques; Male; Micelles; Rabbits; Vitamin K 1	1989
Patulin biosynthesis: epoxidation of toluquinol and gentisyl alcohol by particulate preparations from Penicillium patulum. Biochemistry, 1989, Nov-14, Volume: 28, Issue:23 Topics: Benzyl Alcohols; Benzyl Compounds; Chromatography, Thin Layer; Epoxy Compounds; Ethers, Cyclic; Hydroquinones; Molecular Structure; Oxidoreductases; Patulin; Penicillium; Protease Inhibitors; Pyrans; Vitamin K 1	1989
Determination of trans-phylloquinone in children's serum. Clinical chemistry, 1989, Volume: 35, Issue:5 Topics: Child; Child, Preschool; Chromatography, High Pressure Liquid; Colorimetry; Female; Humans; Indicators and Reagents; Infant; Male; Spectrometry, Fluorescence; Statistics as Topic; Vitamin K 1	1989
Diagnostic importance of vitamin K1 and its epoxide measured in serum of dogs exposed to an anticoagulant rodenticide. American journal of veterinary research, 1989, Volume: 50, Issue:10 Topics: Animals; Anticoagulants; Antidotes; Dog Diseases; Dogs; Female; Male; Phenindione; Rodenticides; Vitamin K 1	1989
Vitamin K-dependent carboxylase. Stoichiometry of vitamin K epoxide formation, gamma-carboxyglutamyl formation, and gamma-glutamyl-3H cleavage. The Journal of biological chemistry, 1988, Mar-05, Volume: 263, Issue:7 Topics: 1-Carboxyglutamic Acid; Animals; Bicarbonates; Carbon; Carbon-Carbon Ligases; Glutamates; Hydrogen; Kinetics; Ligases; Male; Microsomes, Liver; Potassium Cyanide; Rats; Sodium; Sodium Bicarbonate; Vitamin K 1	1988
Synthesis of vitamin K1 2,3-epoxide in rat liver mitochondria. Archives of biochemistry and biophysics, 1988, May-01, Volume: 262, Issue:2 Topics: Animals; Glucose-6-Phosphatase; Male; Microsomes, Liver; Mitochondria, Liver; Rats; Rats, Inbred Strains; Vitamin K; Vitamin K 1	1988
Vitamin K-dependent carboxylase from calf liver: studies on the steady-state kinetic mechanism. Archives of biochemistry and biophysics, 1988, Volume: 264, Issue:1 Topics: Animals; Bicarbonates; Carbon-Carbon Ligases; Cattle; Chlorides; Enzyme Activation; Kinetics; Ligases; Liver; Manganese; Manganese Compounds; Oligopeptides; Sodium; Sodium Bicarbonate; Substrate Specificity; Vitamin K 1	1988
Simultaneous determination of vitamin K1, vitamin K1 2,3-epoxide and menaquinone-4 in human plasma by high-performance liquid chromatography with fluorimetric detection. Journal of chromatography, 1988, Aug-19, Volume: 430, Issue:1 Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Oxidation-Reduction; Perchlorates; Sex Factors; Sodium Compounds; Spectrometry, Fluorescence; Vitamin K; Vitamin K 1; Vitamin K 2	1988
Sulfaquinoxaline inhibition of vitamin K epoxide and quinone reductase. Archives of biochemistry and biophysics, 1989, Feb-15, Volume: 269, Issue:1 Topics: Animals; Drug Resistance; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Quinone Reductases; Rats; Structure-Activity Relationship; Sulfanilamides; Sulfaquinoxaline; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1989
Tissue distribution and warfarin sensitivity of vitamin K epoxide reductase. Biochemical pharmacology, 1988, Mar-01, Volume: 37, Issue:5 Topics: Animals; Dithiothreitol; Kinetics; Microsomes; Mixed Function Oxygenases; Rats; Substrate Specificity; Tissue Distribution; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1988
Mechanism of cephalosporin-induced hypoprothrombinemia: relation to cephalosporin side chain, vitamin K metabolism, and vitamin K status. Journal of clinical pharmacology, 1988, Volume: 28, Issue:1 Topics: Adult; Aged; Cephalosporins; Female; Hemostasis; Humans; Male; Middle Aged; Prothrombin; Prothrombin Time; Structure-Activity Relationship; Vitamin K; Vitamin K 1	1988
Normal and warfarin-resistant rat hepatocyte metabolism of vitamin K 2,3-epoxide: evidence for multiple pathways of hydroxyvitamin K formation. Archives of biochemistry and biophysics, 1988, Volume: 264, Issue:1 Topics: Animals; Cells, Cultured; Dithiothreitol; Drug Resistance; Liver; Male; Rats; Rats, Inbred Strains; Vitamin K; Vitamin K 1; Warfarin	1988
Rat and human liver vitamin K epoxide reductase: inhibition by thiol blockers and vitamin K1. The International journal of biochemistry, 1987, Volume: 19, Issue:11 Topics: Animals; Humans; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Vitamin K 1; Vitamin K Epoxide Reductases	1987
Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of teratogenicity of coumarin derivatives. American journal of human genetics, 1987, Volume: 41, Issue:4 Topics: 1-Carboxyglutamic Acid; Abnormalities, Drug-Induced; Calcium-Binding Proteins; Child; Chromatography, High Pressure Liquid; Female; Fetal Diseases; Fingers; Humans; Male; Nose; Osteocalcin; Phenotype; Pregnancy; Prothrombin; Radiography; Vitamin K; Vitamin K 1; Vitamin K Deficiency; Warfarin	1987
Enantiomers of warfarin and vitamin K1 metabolism. British journal of clinical pharmacology, 1986, Volume: 22, Issue:6 Topics: Half-Life; Humans; Prothrombin Time; Stereoisomerism; Vitamin K 1; Warfarin	1986
Liquid-chromatographic determination of vitamin K1 in plasma, with fluorometric detection. Clinical chemistry, 1986, Volume: 32, Issue:10 Topics: Absorption; Animals; Chromatography, High Pressure Liquid; Electrochemistry; Fasting; Female; Humans; Kinetics; Mice; Oxidation-Reduction; Reference Values; Spectrometry, Fluorescence; Vitamin K 1	1986
Effect of N-methyl-thiotetrazole on vitamin K epoxide reductase. Thrombosis research, 1986, Oct-15, Volume: 44, Issue:2 Topics: Animals; Azoles; Coumarins; Cytosol; Dithiothreitol; Hypoprothrombinemias; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Tetrazoles; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1986
Purification of a vitamin K epoxide reductase that catalyzes conversion of vitamin K 2,3-epoxide to 3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone. Proceedings of the National Academy of Sciences of the United States of America, 1985, Volume: 82, Issue:9 Topics: Animals; Cattle; Dithiothreitol; Microsomes, Liver; Mixed Function Oxygenases; Molecular Weight; Protein Conformation; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1985
Abnormal vitamin K metabolism in the presence of normal clotting factor activity in factory workers exposed to 4-hydroxycoumarins. British journal of clinical pharmacology, 1986, Volume: 21, Issue:3 Topics: 4-Hydroxycoumarins; Adult; Blood Coagulation Disorders; Blood Coagulation Tests; Humans; Male; Occupational Diseases; Prothrombin Time; Vitamin K 1	1986
Vitamin K in infancy. The Journal of pediatrics, 1985, Volume: 106, Issue:3 Topics: Age Factors; Breast Feeding; Factor IX; Factor VII; Factor X; Female; Humans; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Pregnancy; Prothrombin; Risk; Vitamin K; Vitamin K 1; Vitamin K Deficiency; Vitamin K Deficiency Bleeding	1985
Vitamin K epoxide reductase activity in the metabolism of epoxides. Biochemical pharmacology, 1985, Aug-01, Volume: 34, Issue:15 Topics: Animals; Epoxide Hydrolases; Epoxy Compounds; Ethers, Cyclic; In Vitro Techniques; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Trichloroepoxypropane; Vitamin K 1; Vitamin K Epoxide Reductases	1985
Pharmacokinetics of vitamin K1 in low-birth-weight neonates. Developmental pharmacology and therapeutics, 1985, Volume: 8, Issue:5 Topics: Adult; Half-Life; Humans; Infant, Low Birth Weight; Infant, Newborn; Kinetics; Time Factors; Vitamin K 1	1985
Vitamin K1 metabolism in relation to pharmacodynamic response in anticoagulated patients. British journal of clinical pharmacology, 1985, Volume: 20, Issue:6 Topics: Adult; Aged; Anticoagulants; Blood Coagulation Tests; Female; Half-Life; Humans; Male; Middle Aged; Prothrombin Time; Vitamin K; Vitamin K 1; Warfarin	1985
Plasma vitamin K1-2,3-epoxide as diagnostic aid to detect surreptitious ingestion of oral anticoagulant drug. Lancet (London, England), 1983, Mar-12, Volume: 1, Issue:8324 Topics: Administration, Oral; Anticoagulants; Humans; Prothrombin Time; Self Administration; Vitamin K 1	1983
The effects of salicylate on enzymes of vitamin K metabolism. The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:7 Topics: Animals; Liver; Male; Prothrombin; Rats; Salicylates; Salicylic Acid; Vitamin K; Vitamin K 1	1983
Indirect inhibition of vitamin K epoxide reduction by salicylate. The Journal of pharmacy and pharmacology, 1984, Volume: 36, Issue:9 Topics: Animals; Cytosol; Dihydrolipoamide Dehydrogenase; Dithiothreitol; In Vitro Techniques; Liver; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Salicylates; Salicylic Acid; Ticrynafen; Vitamin K 1; Vitamin K Epoxide Reductases	1984
A study of factors which determine the pharmacological response to vitamin K in coumarin anticoagulated rabbits. Biochemical pharmacology, 1984, Oct-01, Volume: 33, Issue:19 Topics: Animals; Blood Coagulation Factors; Coumarins; Male; Prothrombin; Rabbits; Vitamin K; Vitamin K 1	1984
Evidence for impaired hepatic vitamin K1 metabolism in patients treated with N-methyl-thiotetrazole cephalosporins. Thrombosis and haemostasis, 1984, Jul-29, Volume: 51, Issue:3 Topics: Aged; Blood Coagulation Factors; Cefamandole; Female; Glycoproteins; Humans; Liver; Male; Moxalactam; Protein C; Prothrombin Time; Respiratory Tract Infections; Urinary Tract Infections; Vitamin K 1	1984
Quantitative analysis of pharmacological levels of vitamin K1 and vitamin K1 2,3-epoxide in rabbit plasma by high-performance liquid chromatography. Journal of chromatography, 1983, Oct-14, Volume: 277 Topics: Animals; Chromatography, High Pressure Liquid; Injections, Intravenous; Kinetics; Male; Rabbits; Vitamin K 1	1983
Warfarin inhibition of vitamin K 2,3-epoxide reductase in rat liver microsomes. Biochemistry, 1983, Nov-22, Volume: 22, Issue:24 Topics: Animals; Chemical Phenomena; Chemistry; Dithiothreitol; Male; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	1983
Cyclic interconversion of vitamin K1 and vitamin K1 2,3-epoxide in man. British journal of clinical pharmacology, 1983, Volume: 16, Issue:6 Topics: Adult; Half-Life; Humans; Kinetics; Male; Metabolic Clearance Rate; Phenprocoumon; Vitamin K 1	1983
The effect of phenobarbitone pre-treatment on vitamin K1 disposition in the rat and rabbit. Biochemical pharmacology, 1984, Jan-01, Volume: 33, Issue:1 Topics: Animals; Bile; Kinetics; Male; Phenobarbital; Rabbits; Rats; Rats, Inbred Strains; Species Specificity; Vitamin K 1	1984
Improved method for quantitative analysis of vitamin K1 and vitamin K1 2,3-epoxide in human plasma by electron-capture gas-liquid capillary chromatography. Journal of chromatography, 1984, Mar-09, Volume: 306 Topics: Chromatography, Gas; Humans; Stereoisomerism; Vitamin K 1	1984
Formation of 3-hydroxy-2,3-dihydrovitamin K1 in vivo: relationship to vitamin K epoxide reductase and warfarin resistance. The Journal of nutrition, 1984, Volume: 114, Issue:5 Topics: Animals; Chromatography, High Pressure Liquid; Drug Resistance; Liver; Male; Mixed Function Oxygenases; Rats; Vitamin K; Vitamin K 1; Vitamin K Deficiency; Vitamin K Epoxide Reductases; Warfarin	1984
Metabolism of vitamin K and vitamin K 2,3-epoxide via interaction with a common disulfide. Biochemistry, 1984, May-08, Volume: 23, Issue:10 Topics: Animals; Disulfides; Dithiothreitol; Ethylmaleimide; Iodoacetamide; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Vitamin K; Vitamin K 1	1984
Improved method for the determination of vitamin K1 epoxide in human plasma with electrofluorimetric reaction detection. Journal of chromatography, 1984, Apr-27, Volume: 289 Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Spectrometry, Fluorescence; Vitamin K 1	1984
Inhibition by warfarin enantiomers of prothrombin synthesis, protein carboxylation, and the regeneration of vitamin K from vitamin K epoxide. Biochemical pharmacology, 1981, Jul-15, Volume: 30, Issue:14 Topics: Animals; Chemistry, Organic; Depression, Chemical; Epoxy Compounds; In Vitro Techniques; Liver; Organic Chemistry Phenomena; Proteins; Prothrombin; Rats; Stereoisomerism; Vitamin K; Vitamin K 1; Warfarin	1981
Vitamin K1, vitamin K1 epoxide and warfarin interrelationships in the dog. Biochemical pharmacology, 1981, Nov-01, Volume: 30, Issue:21 Topics: Animals; Chemical Phenomena; Chemistry; Dogs; Epoxy Compounds; Male; Time Factors; Vitamin K 1; Warfarin	1981
Inhibition of phylloquinone epoxide-dependent carboxylation of microsomal proteins from rat liver by 2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone. Food and cosmetics toxicology, 1981, Volume: 19, Issue:6 Topics: Animals; Butylated Hydroxytoluene; Cyclohexanes; Cyclohexanones; Dithiothreitol; Epoxy Compounds; In Vitro Techniques; Microsomes, Liver; Proteins; Prothrombin; Quinones; Rats; Rats, Inbred Strains; Subcellular Fractions; Vitamin K; Vitamin K 1	1981
Vitamin K epoxide reductase: evidence that vitamin K dihydroquinone is a product of vitamin K epoxide reduction. Biochemical and biophysical research communications, 1981, Dec-15, Volume: 103, Issue:3 Topics: Animals; Epoxy Compounds; In Vitro Techniques; Male; Mixed Function Oxygenases; Oxidation-Reduction; Rats; Rats, Inbred Strains; Vitamin K 1; Vitamin K Epoxide Reductases	1981
Assay procedure for the vitamin K1 2,3-epoxide-reducing system. Methods in enzymology, 1980, Volume: 67 Topics: Animals; Epoxy Compounds; Liver; Male; Mice; Quail; Rats; Sciuridae; Species Specificity; Subcellular Fractions; Vitamin K 1	1980
Mechanism of the abnormal vitamin K-dependent gamma-carboxylation process in human hepatocellular carcinomas. Cancer, 1994, Sep-01, Volume: 74, Issue:5 Topics: alpha-Fetoproteins; Biomarkers; Carbon-Carbon Ligases; Carcinoma, Hepatocellular; Factor V; Gene Expression Regulation, Neoplastic; Humans; Ligases; Liver; Liver Neoplasms; Microsomes, Liver; Protein Precursors; Prothrombin; RNA; RNA, Neoplasm; Vitamin K; Vitamin K 1; Vitamin K 2	1994
Comparative distribution, metabolism, and utilization of phylloquinone and menaquinone-9 in rat liver. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1995, Volume: 209, Issue:4 Topics: Animals; Carbon-Carbon Ligases; Diet; Ligases; Liver; Male; Microsomes, Liver; Mitochondria, Liver; Rats; Rats, Sprague-Dawley; Vitamin K; Vitamin K 1; Vitamin K 2; Warfarin	1995
Vitamin K1 metabolism and the production of des-carboxy prothrombin and protein C in the term and premature neonate. Blood, 1993, Jan-01, Volume: 81, Issue:1 Topics: Biomarkers; Fetal Blood; Gestational Age; Humans; Infant, Newborn; Infant, Premature; Protein C; Protein Precursors; Prothrombin; Vitamin K 1	1993
Changes in hepatic vitamin K1 levels after prophylactic administration to the newborn. Journal of pediatric gastroenterology and nutrition, 1993, Volume: 16, Issue:1 Topics: Administration, Oral; Chromatography, High Pressure Liquid; Humans; Infant, Newborn; Liver; Vitamin K; Vitamin K 1	1993
High clearance of (S)-warfarin in a warfarin-resistant subject. British journal of clinical pharmacology, 1993, Volume: 35, Issue:3 Topics: Adult; Blood Coagulation; Drug Resistance; Female; Humans; Male; Stereoisomerism; Vitamin K; Vitamin K 1; Warfarin	1993
Assessment of vitamin K status in human subjects administered "minidose" warfarin. The American journal of clinical nutrition, 1996, Volume: 64, Issue:6 Topics: 1-Carboxyglutamic Acid; Adult; Aged; Anticoagulants; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Incidence; Male; Middle Aged; Osteocalcin; Prothrombin; Thrombosis; Vitamin K; Vitamin K 1; Warfarin	1996
Natural prenylquinones inhibit the enzymes of the vitamin K cycle in vitro. Biochimica et biophysica acta, 1996, Nov-14, Volume: 1298, Issue:1 Topics: Animals; Carbon-Carbon Ligases; Cattle; Electrochemistry; Enzyme Inhibitors; Hydroquinones; Ligases; Microsomes, Liver; Mixed Function Oxygenases; Molecular Structure; Oxidation-Reduction; Plants; Plastoquinone; Quinones; Rats; Rats, Inbred Lew; Ubiquinone; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases	1996
Determination of vitamin K compounds in plasma or serum by high-performance liquid chromatography using postcolumn chemical reduction and fluorimetric detection. Methods in enzymology, 1997, Volume: 282 Topics: Adult; Aged; Blood; Brassica; Chromatography, High Pressure Liquid; Diet; Female; Humans; Indicators and Reagents; Male; Middle Aged; Oxidation-Reduction; Plasma; Reference Values; Sensitivity and Specificity; Sex Characteristics; Spectrometry, Fluorescence; Vitamin K; Vitamin K 1	1997
Assay of phylloquinone and menaquinones in human liver. Methods in enzymology, 1997, Volume: 282 Topics: Chromatography, High Pressure Liquid; Hepatitis, Chronic; Humans; Indicators and Reagents; Liver; Liver Cirrhosis; Reference Values; Vitamin K; Vitamin K 1	1997
The influence of (R)- and (S)-warfarin, vitamin K and vitamin K epoxide upon warfarin anticoagulation. Thrombosis and haemostasis, 2000, Volume: 84, Issue:1 Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anticoagulants; Blood Coagulation; Blood Coagulation Factors; Drug Resistance; Female; Genetic Variation; Humans; International Normalized Ratio; Liver; Male; Middle Aged; Multivariate Analysis; Stereoisomerism; Vitamin K; Vitamin K 1; Warfarin	2000
The association of vitamin K status with warfarin sensitivity at the onset of treatment. British journal of haematology, 2001, Volume: 112, Issue:3 Topics: Aged; Anticoagulants; Biomarkers; Female; Humans; International Normalized Ratio; Linear Models; Male; Middle Aged; Nutritional Status; Preoperative Care; Protein Precursors; Prothrombin; Treatment Outcome; Triglycerides; Vitamin K; Vitamin K 1; Warfarin	2001
Characterization and purification of the vitamin K1 2,3 epoxide reductases system from rat liver. The Journal of pharmacy and pharmacology, 2001, Volume: 53, Issue:4 Topics: Animals; Benzoquinones; Binding Sites; Catalysis; Chromatography, High Pressure Liquid; Endoplasmic Reticulum; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Rats; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2001
Congenital deficiency of vitamin K dependent coagulation factors--its rarity and need for an international registry. Thrombosis and haemostasis, 2001, Volume: 86, Issue:4 Topics: Carbon-Carbon Ligases; Consanguinity; Global Health; Hemorrhagic Disorders; Humans; India; Infant, Newborn; Mixed Function Oxygenases; Registries; Vitamin K 1; Vitamin K Epoxide Reductases	2001
Homozygosity mapping of a second gene locus for hereditary combined deficiency of vitamin K-dependent clotting factors to the centromeric region of chromosome 16. Blood, 2002, Nov-01, Volume: 100, Issue:9 Topics: Animals; Blood Coagulation Factors; Centromere; Child; Chromosome Mapping; Chromosomes, Human, Pair 16; DNA Mutational Analysis; Drug Resistance; Female; Genes, Recessive; Genetic Markers; Genotype; Germany; Glutathione Transferase; Hemorrhagic Disorders; Humans; Infant, Newborn; Lebanon; Lod Score; Male; Mice; Microsatellite Repeats; Mixed Function Oxygenases; Multienzyme Complexes; Pedigree; Rats; Species Specificity; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2002
Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition. Toxicology, 2003, Aug-01, Volume: 189, Issue:3 Topics: Animals; Anticoagulants; Cattle; Dogs; Female; Horses; Humans; Inhibitory Concentration 50; Kinetics; Male; Mice; Microsomes, Liver; Mixed Function Oxygenases; Rats; Sheep; Species Specificity; Swine; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2003
Site-directed mutagenesis of coumarin-type anticoagulant-sensitive VKORC1: evidence that highly conserved amino acids define structural requirements for enzymatic activity and inhibition by warfarin. Thrombosis and haemostasis, 2005, Volume: 94, Issue:4 Topics: Amino Acid Sequence; Anticoagulants; Binding Sites; Cell Line; Coumarins; Disulfides; Drug Resistance; Humans; Hydrophobic and Hydrophilic Interactions; Kidney; Mixed Function Oxygenases; Molecular Sequence Data; Mutagenesis, Site-Directed; Vitamin K 1; Vitamin K Epoxide Reductases	2005
Disulfide-dependent protein folding is linked to operation of the vitamin K cycle in the endoplasmic reticulum. A protein disulfide isomerase-VKORC1 redox enzyme complex appears to be responsible for vitamin K1 2,3-epoxide reduction. The Journal of biological chemistry, 2007, Jan-26, Volume: 282, Issue:4 Topics: Animals; Biological Transport; Carbon-Carbon Ligases; Cell Line; Cricetinae; Endoplasmic Reticulum; Mixed Function Oxygenases; Oxidation-Reduction; Protein Disulfide-Isomerases; Protein Folding; Toluene; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases	2007
Purified vitamin K epoxide reductase alone is sufficient for conversion of vitamin K epoxide to vitamin K and vitamin K to vitamin KH2. Proceedings of the National Academy of Sciences of the United States of America, 2006, Dec-19, Volume: 103, Issue:51 Topics: Baculoviridae; Genetic Vectors; Humans; Mixed Function Oxygenases; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2006
The conversion of vitamin K epoxide to vitamin K quinone and vitamin K quinone to vitamin K hydroquinone uses the same active site cysteines. Biochemistry, 2007, Jun-19, Volume: 46, Issue:24 Topics: Amino Acid Substitution; Catalytic Domain; Cysteine; Disulfides; Enzyme Inhibitors; Kinetics; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Vitamin K 1; Vitamin K 2; Vitamin K Epoxide Reductases; Warfarin	2007
Clinical studies on dicumarol hypoprothrombinemia and vitamin K preparations; superiority of vitamin K1 oxide over menadione sodium bisulfite U.S.P. and synkayvite in reversing dicumarol hypoprothrombinemia. Archives of internal medicine (Chicago, Ill. : 1908), 1949, Volume: 83, Issue:6 Topics: Blood Coagulation; Dicumarol; Humans; Hypoprothrombinemias; Vitamin K; Vitamin K 1; Vitamin K 3	1949
Studies on dicumarol in human beings; its neutralization by vitamin K1 oxide, menadione bisulfite, synkayvite and blood. The American journal of medicine, 1948, Volume: 4, Issue:3 Topics: Dicumarol; Humans; Vitamin K; Vitamin K 1; Vitamin K 3	1948
Studies on dicumarol in human beings; its neutralization by vitamin K1 oxide, menadione bisulfite, synkayvite and blood. The Journal of clinical investigation, 1948, Volume: 27, Issue:4 Topics: Dicumarol; Vitamin K; Vitamin K 1; Vitamin K 3	1948
A possible ethanol-catalyzed rearrangement of vitamin K(1) detected by gas chromatography/mass spectrometry. Rapid communications in mass spectrometry : RCM, 2008, Volume: 22, Issue:23 Topics: Ethanol; Gas Chromatography-Mass Spectrometry; Hexanes; Isomerism; Molecular Structure; Vitamin K 1	2008
Ethnic differences in the population pharmacokinetics and pharmacodynamics of warfarin. Journal of pharmacokinetics and pharmacodynamics, 2010, Volume: 37, Issue:1 Topics: Adult; Anticoagulants; Aryl Hydrocarbon Hydroxylases; Asian People; Bayes Theorem; Computer Simulation; Cytochrome P-450 CYP2C9; Fibrinolytic Agents; Genotype; Humans; Male; Middle Aged; Mixed Function Oxygenases; Nonlinear Dynamics; Polymorphism, Genetic; Retrospective Studies; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2010
Novel insight into the mechanism of the vitamin K oxidoreductase (VKOR): electron relay through Cys43 and Cys51 reduces VKOR to allow vitamin K reduction and facilitation of vitamin K-dependent protein carboxylation. The Journal of biological chemistry, 2011, Mar-04, Volume: 286, Issue:9 Topics: Animals; Catalysis; Cell Membrane; Cells, Cultured; Cysteine; Disulfides; Electrons; Enzyme Activation; Humans; Insecta; Microsomes; Mixed Function Oxygenases; Mutagenesis, Site-Directed; Oxidation-Reduction; Thioredoxin-Disulfide Reductase; Thioredoxins; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases	2011
Functional study of the vitamin K cycle in mammalian cells. Blood, 2011, Mar-10, Volume: 117, Issue:10 Topics: Anticoagulants; Cell Line; Clinical Laboratory Techniques; HEK293 Cells; Humans; Mixed Function Oxygenases; Signal Transduction; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2011
A novel mutation in VKORC1 and its effect on enzymatic activity in Japanese warfarin-resistant rats. The Journal of veterinary medical science, 2013, Volume: 75, Issue:2 Topics: Animals; Female; Gene Expression Regulation, Enzymologic; Japan; Male; Metabolism, Inborn Errors; Mixed Function Oxygenases; Mutation; Rats; Rats, Sprague-Dawley; RNA, Messenger; Rodenticides; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2013
Rapid, high performance method for the determination of vitamin K(1), menaquinone-4 and vitamin K(1) 2,3-epoxide in human serum and plasma using liquid chromatography-hybrid quadrupole linear ion trap mass spectrometry. Journal of chromatography. A, 2014, Apr-18, Volume: 1338 Topics: Chromatography, High Pressure Liquid; Epoxy Compounds; Humans; Tandem Mass Spectrometry; Time Factors; Vitamin K; Vitamin K 1; Vitamin K 2; Vitamins	2014
Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer. Nature structural & molecular biology, 2017, Volume: 24, Issue:1 Topics: Biocatalysis; Catalytic Domain; HEK293 Cells; Humans; Molecular Docking Simulation; Oxidation-Reduction; Protein Binding; Vitamin K 1; Vitamin K 2; Vitamin K Epoxide Reductases; Warfarin	2017
Warfarin and vitamin K compete for binding to Phe55 in human VKOR. Nature structural & molecular biology, 2017, Volume: 24, Issue:1 Topics: Biocatalysis; Catalytic Domain; Drug Resistance; HEK293 Cells; Humans; Molecular Docking Simulation; Oxidation-Reduction; Phenylalanine; Protein Binding; Protein Conformation, alpha-Helical; Vitamin K 1; Vitamin K 2; Vitamin K Epoxide Reductases; Warfarin	2017
Functional Study of the Vitamin K Cycle Enzymes in Live Cells. Methods in enzymology, 2017, Volume: 584 Topics: Animals; Enzyme Assays; Enzyme-Linked Immunosorbent Assay; Humans; NAD(P)H Dehydrogenase (Quinone); Protein Processing, Post-Translational; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases	2017
Erythema multiforme-like reaction resulting from vitamin K Contact dermatitis, 2017, Volume: 77, Issue:5 Topics: Adult; Child; Dermatitis, Allergic Contact; Epoxy Compounds; Erythema Multiforme; Female; Gels; Humans; Male; Skin Cream; Vitamin K 1	2017
Warfarin alters vitamin K metabolism: a surprising mechanism of VKORC1 uncoupling necessitates an additional reductase. Blood, 2018, 06-21, Volume: 131, Issue:25 Topics: Animals; Anticoagulants; Cell Line; Cricetinae; Drug Resistance; Humans; Oxidation-Reduction; Point Mutation; Vitamin K; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2018
"Crossed" allergic contact dermatitis caused by oxidized vitamin K Contact dermatitis, 2019, Volume: 80, Issue:1 Topics: Cosmetics; Cross Reactions; Dermatitis, Allergic Contact; Facial Dermatoses; Female; Humans; Middle Aged; Vitamin K 1; Vitamins	2019
Structural Investigation of the Vitamin K Epoxide Reductase (VKORC1) Binding Site with Vitamin K. Biochemistry, 2020, 04-07, Volume: 59, Issue:13 Topics: Amino Acid Motifs; Binding Sites; Catalytic Domain; Humans; Models, Molecular; Vitamin K 1; Vitamin K Epoxide Reductases	2020
Structural features determining the vitamin K epoxide reduction activity in the VKOR family of membrane oxidoreductases. The FEBS journal, 2022, Volume: 289, Issue:15 Topics: Epoxy Compounds; Humans; Oxidoreductases; Vitamin K 1; Vitamin K Epoxide Reductases; Warfarin	2022