vitamin-k-1 and menadiol

vitamin-k-1 has been researched along with menadiol* in 10 studies

Trials

1 trial(s) available for vitamin-k-1 and menadiol

Article	Year
Phytomenadione or menadiol in the management of an elevated international normalized ratio (prothrombin time). Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:12 To evaluate the efficacy of oral menadiol compared to intravenous phytomenadione when correcting coagulopathies associated with cholestasis.. A total of 26 patients with cholestasis and an international normalized ratio (prothrombin time) greater than 1.2, were randomized to receive either 20 mg o.d. for 3 days of oral menadiol (n=12), or 10 mg o.d. of intravenous phytomenadione (n=14) prior to endoscopic retrograde cholangeopancreatography. Liver function tests and international normalized ratio were measured daily for 3 days.. Liver function tests and international normalized ratio were comparable between groups at entry into the study (P > 0.05), but serum albumin was significantly lower in the intravenous phytomenadione group following treatment (P < 0.05). A decrease in international normalized ratio occurred in both groups following administration of vitamin K (P < 0.05). Two patients in the intravenous group required fresh frozen plasma, as failure to normalize international normalized ratio was observed. No adverse drug reactions were observed in either group, and no patient required re-admission for bleeding during a 4-week follow-up period after cholangeopancreatography.. Oral menadiol appears to be an effective alternative to intravenous phytomenadione in the correction of coagulopathies associated with obstructive liver disease. This simplifies the care of patients with deranged clotting times requiring cholangeopancreatography, particularly those to be managed as out-patients. Topics: Aged; Aged, 80 and over; Blood Coagulation Disorders; Cholestasis; Female; Humans; Male; Middle Aged; Prothrombin Time; Vitamin K; Vitamin K 1	2000

Article

Year

Phytomenadione or menadiol in the management of an elevated international normalized ratio (prothrombin time).

Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:12

To evaluate the efficacy of oral menadiol compared to intravenous phytomenadione when correcting coagulopathies associated with cholestasis.. A total of 26 patients with cholestasis and an international normalized ratio (prothrombin time) greater than 1.2, were randomized to receive either 20 mg o.d. for 3 days of oral menadiol (n=12), or 10 mg o.d. of intravenous phytomenadione (n=14) prior to endoscopic retrograde cholangeopancreatography. Liver function tests and international normalized ratio were measured daily for 3 days.. Liver function tests and international normalized ratio were comparable between groups at entry into the study (P > 0.05), but serum albumin was significantly lower in the intravenous phytomenadione group following treatment (P < 0.05). A decrease in international normalized ratio occurred in both groups following administration of vitamin K (P < 0.05). Two patients in the intravenous group required fresh frozen plasma, as failure to normalize international normalized ratio was observed. No adverse drug reactions were observed in either group, and no patient required re-admission for bleeding during a 4-week follow-up period after cholangeopancreatography.. Oral menadiol appears to be an effective alternative to intravenous phytomenadione in the correction of coagulopathies associated with obstructive liver disease. This simplifies the care of patients with deranged clotting times requiring cholangeopancreatography, particularly those to be managed as out-patients.

Topics: Aged; Aged, 80 and over; Blood Coagulation Disorders; Cholestasis; Female; Humans; Male; Middle Aged; Prothrombin Time; Vitamin K; Vitamin K 1

2000

Other Studies

9 other study(ies) available for vitamin-k-1 and menadiol

Article	Year
[The effect of konakion or synkavite prophylaxis on prothrombin levels in newborn infants]. Gynaecologia. International monthly review of obstetrics and gynecology. Revue internationale mensuelle d'obstetrique et de gynecologie. Monatsschrift fur Geburtshilfe und Gynakologie, 1957, Volume: 144, Issue:2 Topics: Antifibrinolytic Agents; Hemostatics; Humans; Infant; Infant, Newborn; Naphthoquinones; Prothrombin; Vitamin K; Vitamin K 1	1957
Comparison of the action of vitamin K1 with that of synkavit in the newborn. Acta paediatrica, 1954, Volume: 43, Issue:1 Topics: Antifibrinolytic Agents; Hemostatics; Humans; Infant, Newborn; Naphthoquinones; Prothrombin Time; Vitamin K; Vitamin K 1	1954
Influence of vitamin K1 and synkavit given ante partum on the prothrombin time of the newborn. Acta obstetricia et gynecologica Scandinavica, 1954, Volume: 33, Issue:3 Topics: Antifibrinolytic Agents; Hemostatics; Infant, Newborn; Leadership; Prothrombin Time; Vitamin K; Vitamin K 1	1954
Faster action of vitamin K1 than of menadione and synkavit intravenously injected into vitamin K-deficient chicks. Experientia, 1953, 01-15, Volume: 9, Issue:1 Topics: Animals; Antifibrinolytic Agents; Chickens; Naphthoquinones; Vitamin K; Vitamin K 1; Vitamin K 3; Vitamin K Deficiency	1953
[Evaluation of liver function by determination of factor V, factor VII and prothrombin; effects of synkavit and vitamin K1]. Munchener medizinische Wochenschrift (1950), 1953, Apr-10, Volume: 95, Issue:15 Topics: Blood Coagulation; Blood Coagulation Tests; Factor V; Factor VII; Hemostatics; Humans; Liver; Liver Function Tests; Prothrombin; Prothrombin Time; Vitamin K; Vitamin K 1	1953
Comparison of the action of vitamin K1, Menadione and synkavit administered intravenously to vitamin K deficient chicks. Acta pharmacologica et toxicologica, 1953, Volume: 9, Issue:2 Topics: Animals; Antifibrinolytic Agents; Chickens; Hemostatics; Vitamin K; Vitamin K 1; Vitamin K 3; Vitamin K Deficiency	1953
Clinical studies on dicumarol hypoprothrombinemia and vitamin K preparations; superiority of vitamin K1 oxide over menadione sodium bisulfite U.S.P. and synkayvite in reversing dicumarol hypoprothrombinemia. Archives of internal medicine (Chicago, Ill. : 1908), 1949, Volume: 83, Issue:6 Topics: Blood Coagulation; Dicumarol; Humans; Hypoprothrombinemias; Vitamin K; Vitamin K 1; Vitamin K 3	1949
Studies on dicumarol in human beings; its neutralization by vitamin K1 oxide, menadione bisulfite, synkayvite and blood. The American journal of medicine, 1948, Volume: 4, Issue:3 Topics: Dicumarol; Humans; Vitamin K; Vitamin K 1; Vitamin K 3	1948
Studies on dicumarol in human beings; its neutralization by vitamin K1 oxide, menadione bisulfite, synkayvite and blood. The Journal of clinical investigation, 1948, Volume: 27, Issue:4 Topics: Dicumarol; Vitamin K; Vitamin K 1; Vitamin K 3	1948