viomellein has been researched along with xanthomegnin* in 8 studies
8 other study(ies) available for viomellein and xanthomegnin
Article | Year |
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Bis-naphthopyrone pigments protect filamentous ascomycetes from a wide range of predators.
It is thought that fungi protect themselves from predation by the production of compounds that are toxic to soil-dwelling animals. Here, we show that a nontoxic pigment, the bis-naphthopyrone aurofusarin, protects Fusarium fungi from a wide range of animal predators. We find that springtails (primitive hexapods), woodlice (crustaceans), and mealworms (insects) prefer feeding on fungi with disrupted aurofusarin synthesis, and mealworms and springtails are repelled by wheat flour amended with the fungal bis-naphthopyrones aurofusarin, viomellein, or xanthomegnin. Predation stimulates aurofusarin synthesis in several Fusarium species and viomellein synthesis in Aspergillus ochraceus. Aurofusarin displays low toxicity in mealworms, springtails, isopods, Drosophila, and insect cells, contradicting the common view that fungal defence metabolites are toxic. Our results indicate that bis-naphthopyrones are defence compounds that protect filamentous ascomycetes from predators through a mechanism that does not involve toxicity. Topics: Adaptation, Physiological; Animals; Arthropods; Aspergillus ochraceus; Food Preferences; Fusarium; Naphthoquinones; Pigments, Biological; Predatory Behavior | 2019 |
Anti-dormant Mycobacterial Activity of Viomellein and Xanthomegnin, Naphthoquinone Dimers Produced by Marine- derived Aspergillus sp.
In the course of a search for anti-dormant mycobacterial substances from marine-derived microorganisms, viomellein (1) and xanthomegnin (2) were re- discovered from the active fraction of the culture of a marine-derived Aspergillus sp. together with rubrosulphin (3) and asteltoxin (4) on the guidance of bioassay-guided separation. In particular, compound 1 showed higher activity against the dormant than against actively growing Mycobacterium bovis BCG and weak activity against M smegmatis. Furthermore, evidence that compound 1 did not directly bind to plasmid DNA suggests its anti-mycobacterial activity differs from its direct chelating effect on the mycobacterial genome. Topics: Antitubercular Agents; Aspergillus; Dimerization; Microbial Sensitivity Tests; Mycobacterium; Naphthoquinones; Seawater | 2017 |
2D-PAGE examination of mRNA populations from Penicillium freii mutants deficient in xanthomegnin biosynthesis.
Penicillium freii (Lund and Frisvad 1994) mutants deficient in the synthesis of xanthomegnin were isolated. In vitro translated mRNA populations from selected radiation induced mutants and naturally occurring P. freii strains not able to produce xanthomegnin were examined by 2-dimensional polyacrylamide gel electrophoresis (2D-PAGE). Specific translation products were absent in mutants and natural isolates unable to produce xanthomegnin metabolites. One mutant (TSM 73) did not produce several of these translation products, indicating that a mutation in a regulatory gene involved in xanthomegnin production had occurred. Topics: Electrophoresis, Gel, Two-Dimensional; Fungal Proteins; Gene Expression Regulation, Fungal; Genetic Variation; Hydroxyquinolines; Mutagenesis; Naphthoquinones; Penicillium; Protein Biosynthesis; RNA, Messenger; Xanthine; Xanthines | 1996 |
Studies on the refrigerated storage of wheat (Triticum aestivum). 2. Ergosterol, xanthomegnin, viomellein and brevianamide A after inoculation with Penicillium viridicatum.
Wheat seed was adjusted to 18, 20, 22, 24 and 26% moisture content (m.c.), and stored for 240 days at 4 or 10 degrees C following inoculation with a strain of Penicillium viridicatum producing the toxins, xanthomegnin (XA), viomellein (VIO), and brevianamide A (BA). Wheat kernels were not sterilized before inoculation. The concentration of ergosterol (ERG), a chemical indicator of fungal biomass, remained constant at 18% m.c./4 degrees C, but increased under the other conditions. The time before a detectable increase of ERG concentration was higher and the rate of ERG production lower with decreasing moisture content and temperature. XA and BA were produced at both temperatures at 20-26% m.c., VIO was produced at 22-26% m.c./4 degrees C and 20-26% m.c./10 degrees C. The results suggest or indicate that the onset of XA, VIO and BA production (detection limits: 10, 15, and 0.1 micrograms/kg, respectively) coincided with the onset of ERG production. Maximum toxin contents were lower with decreasing moisture content at both temperatures, but were similar at 4 and 10 degrees C at 22-26% m.c. It is concluded that wheat contaminated with P. viridicatum should not be stored beyond the onset of ergosterol production; maximum storage periods are recommended. Topics: Alkaloids; Cold Temperature; Ergosterol; Food Microbiology; Food Preservation; Mycotoxins; Naphthoquinones; Penicillium; Pigments, Biological; Piperazines; Refrigeration; Seeds; Spiro Compounds; Triticum | 1993 |
A selective and indicative medium for groups of Penicillium viridicatum producing different mycotoxins in cereals.
A medium, pentachloronitrobenzene-rose bengal-yeast extract-sucrose agar (PRYES), for the isolation of moulds occurring during storage of cereals has been developed and compared with other selective media. The basal medium is yeast extract agar containing 15% sucrose (w/v). In addition to the sucrose content further selective measures include the addition of antibacterial antibiotics chloramphenicol and chlortetracycline (50 mg/l), the fungicides rose bengal (25 mg/l each), and pentachloronitrobenzene (1 g/l) and a low incubation temperature (20 degrees C). Members of the Mucorales were completely inhibited, and fast-growing species of other moulds were slightly inhibited, allowing important storage moulds to develop. The important ochratoxin A and citrinin-producing Penicillium viridicatum group II was indicated by a typical violet brown reverse on PRYES. Producers of xanthomegnin and viomellein (P. viridicatum group I and P. aurantiogriseum) were indicated on PRYES by their yellow reverse and obverse colours. The medium was used for screening 40 samples of barley, and moulds with the characteristic colours were all identified as the species mentioned above. Topics: Citrinin; Culture Media; Edible Grain; Food Microbiology; Hordeum; Mycotoxins; Naphthoquinones; Ochratoxins; Penicillium; Triticum | 1983 |
Production of xanthomegnin and viomellein by isolates of Aspergillus ochraceus, Penicillium cyclopium, and Penicillium viridicatum.
Fungal isolates from legumes were cultured on rice and examined for production of the toxic mold metabolites xanthomegnin and viomellein. Six of 14 Aspergillus ochraceus isolates produced from 0.3 to 1.3 mg of xanthomegnin per g and 0.1 to 1.0 mg of viomellein per g. One of nine isolates of Penicillium cyclopium produced 0.1 mg of xanthomegnin per g and 0.06 mg of viomellein per g. Three of nine P. viridicatum isolates produced from 0.4 to 1.6 mg of xanthomegnin per g and 0.2 to 0.4 mg of viomellein per g. This is the first report of xanthomegnin and viomellein production by A. ochraeus and P. cyclopium. Topics: Aspergillus; Culture Media; Fabaceae; Food Microbiology; Mycotoxins; Naphthoquinones; Oryza; Penicillium; Plants, Medicinal; Species Specificity | 1978 |
Production of xanthomegnin and viomellein by species of Aspergillus correlated with mycotoxicosis produced in mice.
By using thin-layer chromatography and infrared spectroscopy, xanthomegnin and viomellein have been isolated and identified from species of the Aspergillus ochraceus group. A correlation was established between the occurrence of these fungal quinones in the fungal cultural products and the ability of these products to induce mycotoxicosis in mice. In addition, a method was employed to estimate the amount of xanthomegnin and viomellein produced by the fungi. Topics: Animals; Aspergillus; Chromatography, Thin Layer; Female; Male; Mice; Mycotoxins; Naphthoquinones; Species Specificity; Spectrophotometry, Infrared | 1978 |
Hepatic alterations produced in mice by xanthomegnin and viomellein, metabolites of Penicillium viridicatum.
Topics: Animals; Biotransformation; Chemical and Drug Induced Liver Injury; Diet; Kidney; Liver; Male; Mice; Mycotoxins; Naphthoquinones; Penicillium; Pigments, Biological | 1976 |