Page last updated: 2024-08-17

vincristine and colchicine

vincristine has been researched along with colchicine in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (1.89)	18.7374
1990's	7 (13.21)	18.2507
2000's	19 (35.85)	29.6817
2010's	23 (43.40)	24.3611
2020's	3 (5.66)	2.80

Authors

Authors	Studies
Noker, PE; Rener, GA; Temple, C; Waud, WR	1
Rener, GA; Temple, C	1
Hansch, C; Khwaja, TA; Selassie, CD	1
Comber, RN; Rener, GA; Temple, C	1
Chai, H; Cruz, JG; Hernández, L; Mar, W; Novelo, M; Pereda-Miranda, R; Pezzuto, JM	1
Barrows, LR; Ireland, CM; Kokoshka, JM	1
Cole, SP; Deeley, RG; Grant, CE; Hipfner, DR; Loe, DW; Stride, BD	1
Hashimoto, Y; Koiso, Y; Nishikawa, A; Shirai, R; Takayama, H	1
Akiyama, S; Kobayashi, M; Morita, M; Murakami, N; Sugimoto, M	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Baasner, S; Beckers, T; Böhmer, FD; Burger, AM; Bürgermeister, J; Fiebig, HH; Frieser, M; Hockemeyer, J; Hufsky, H; Lyssenko, A; Mahboobi, S; Paper, DH; Pongratz, H	1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Chang, JY; Chang, YL; Chen, CP; Chen, CT; Chen, LT; Hsieh, HP; Kuo, CC; Lee, SJ; Liou, JP; Pan, WY	1
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Prinz, H; Schmidt, P; Unger, E; Zuse, A	2
Afragola, J; Ayral-Kaloustian, S; Beyer, C; Gibbons, J; Hernandez, R; Lucas, J; Nguyen, T; Zhang, N	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Copper, JE; Gangjee, A; Smith, CD; Yu, J	1
Bednarski, PJ; Gastpar, R; Kaufmann, D; Nishino, T; Pojarová, M; Reszka, P; von Angerer, E	1
Attardo, G; Bubenick, M; Cai, SX; Crogan-Grundy, C; Denis, R; Drewe, J; Gourdeau, H; Jiang, S; Kasibhatla, S; Kemnitzer, W; Labreque, D; Lamothe, S; Tseng, B; Zhang, H	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Bednarski, PJ; Kaufmann, D; Kühne, S; Müller, C; Pfaller, T; Pojarová, M; Vogel, S; von Angerer, E	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chang, CY; Chang, JY; Chiang, YK; Coumar, MS; Hsieh, HP; Kuo, CC; Lai, MJ; Liou, JP; Reddy, GR; Tan, UK; Wu, SY; Yeh, JY	1
Baruchello, R; Durrant, D; Eleopra, M; Grisolia, G; Invidiata, FP; Kellogg, GE; Lee, RM; Marchetti, P; Rondanin, R; Simoni, D; Tripathi, A	1
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Prinz, H; Schmidt, P; Unger, E	2
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Nickel, HC; Prinz, H; Schmidt, P; Unger, E	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Bukhtiyarova, M; Chao, W; Dorsey, BD; Flubacher, D; Flynn, GA; Fujimoto, T; Husain, A; Joseph, RW; Kelly, MJ; Lee, KJ; Lee, Y; Liu, B; Lu, Y; Mihelcic, J; Moffett, KK; Moore, WR; Nelson, D; Ochman, AR; Saporito, MS; Schumacher, A; Shetty, RS; Springman, EB; Stojanovic, A; Williams, K	1
Bastow, KF; Goto, M; Hamel, E; Kozaka, T; Lai, CY; Lee, KH; Nakagawa-Goto, K; Ohkoshi, E; Wu, PC; Zhang, L; Zhu, H	1
Chalmers, DK; Chaplin, JH; Charman, SA; Flynn, BL; Gill, GS; Grobelny, DW; Hamel, E; Jung, MK; Kostewicz, E; Kremmidiotis, G; Lavranos, TC; Leske, AF; Morizzi, J; Paul, D; Shackleford, DM	1
Chang, CY; Chang, JY; Kuo, CC; Lai, WY; Lee, HY; Liou, JP; Nien, CY; Shih, KH; Wu, CH	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Akula, B; Bharathi, EV; Billa, VK; Cosenza, SC; Gallo, JM; Lv, H; Mallireddigari, MR; Padgaonkar, A; Pallela, VR; Reddy, EP; Reddy, MV; Subbaiah, DR	1
Chang, CY; Chang, JY; Chang, YT; Kuo, CC; Lai, MJ; Lee, HY; Liou, JP; Liu, YM; Mehndiratta, S; Nien, CY; Pan, SL; Su, MC; Wu, JS; Wu, SY	1
Ma, L; Meng, T; Miao, Z; Shen, J; Wang, W; Zhang, Y; Zhang, Z	1
Guan, F; Guo, W; Hamel, E; Lee, KH; Li, L; Morris-Natschke, SL; Ohkoshi, E; Qian, K; Wang, L; Wang, LT; Wang, SB; Wang, XF; Xie, L; Yang, D; Yuan, S; Zhu, DQ	1
Chang, CY; Chang, JY; Chuang, HY; Kuo, CC; Lee, HY; Liou, JP; Yeh, TK	1
Alfonsi, R; Bai, R; Bolognesi, A; Brancale, A; Coluccia, A; Di Marcotullio, L; Dondio, G; Famiglini, V; Gulino, A; Hamel, E; La Regina, G; Lavia, P; Mazzoccoli, C; Mercurio, C; Miele, A; Nalli, M; Novellino, E; Passacantilli, S; Pelliccia, S; Rensen, WM; Ruggieri, V; Silvestri, R; Sisinni, L; Varasi, M; Vultaggio, S	1
Chang, CY; Chang, JY; Chen, MC; Chiang, YF; Kuo, CC; Lai, MJ; Lee, HY; Liou, JP; Mehndiratta, S	1
Bu, X; Chen, Y; Du, J; Huang, L; Liang, B; Shang, N; Wang, R; Wen, G; Yue, X; Zhu, C; Zuo, Y	1
Chang, CY; Chang, JY; Chuang, HY; Kuo, CC; Lai, MJ; Lee, HY; Liou, JP	1
Chang, LH; Chen, MC; Chuang, HY; Huang, HL; Lai, MJ; Lee, HY; Liou, JP; Liu, YM; Mehndiratta, S; Pan, SL; Teng, CM; Tsai, AC; Wu, YW	1
Brett, ML; Colley, HE; Coole, SF; Danson, SJ; Dossetter, AG; Griffen, EJ; Harrison, J; Jackson, LV; Jennings, LR; Lockey, PM; Mason, DP; Muthana, M; Norman, D; Thompson, MJ; Tulasi, V; Williams, L; Wong, M	1
An, W; Meng, T; Miao, Z; Shen, J; Wang, W; Yu, T; Zhang, Y	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bikman, BT; Blomfield, MP; Evans, AT; Fox, JC; Hansen, MDH; Hill, JT; Livingstone, SK; Perry, K; Tenney, SR; Webster, JB	1
Bai, X; Chen, H; De Brabander, JK; Kim, J; Liou, J; McFadden, DG; Posner, B; Povedano, JM; Rallabandi, R; Rice, L; Xie, Y; Ye, X	1
Han, L; Huang, X; Jin, X; Li, X; Liang, B; Ouyang, F; Xu, Y; Yan, J; Zhan, M; Zhang, Q	1
Li, X; Lin, H; OuYang, F; Pang, Y; Yan, J; Zhang, W; Zhou, J	1

Reviews

1 review(s) available for vincristine and colchicine

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

52 other study(ies) available for vincristine and colchicine

Article	Year
Antimitotic agents: structure-activity studies with some pyridine derivatives. Journal of medicinal chemistry, 1992, Oct-02, Volume: 35, Issue:20 Topics: Animals; Antineoplastic Agents; Cell Division; Female; Leukemia L1210; Mice; Pyridines; Structure-Activity Relationship; Tumor Cells, Cultured	1992
Antimitotic agents: ring analogues and derivatives of ethyl [(S)-5-amino-1,2-dihydro-2-methyl-3-phenylpyrido[3,4-b]pyrazin-7- yl]carbamate. Journal of medicinal chemistry, 1992, Dec-25, Volume: 35, Issue:26 Topics: Animals; Antineoplastic Agents; Cell Division; Cells, Cultured; Leukemia L1210; Pyrazines; Stereoisomerism; Structure-Activity Relationship; Urethane	1992
Structure-activity relationships of antineoplastic agents in multidrug resistance. Journal of medicinal chemistry, 1990, Volume: 33, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured	1990
New anticancer agents: alterations of the carbamate group of ethyl (5-amino-1,2-dihydro-3-phenylpyrido[3,4-b]pyrazin-7-yl)car bamates. Journal of medicinal chemistry, 1989, Volume: 32, Issue:10 Topics: Animals; Antineoplastic Agents; Carbamates; Cell Survival; Indicators and Reagents; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Pyridazines; Structure-Activity Relationship; Tumor Cells, Cultured	1989
Cytotoxic constituents from Hyptis verticillata. Journal of natural products, 1993, Volume: 56, Issue:10 Topics: Animals; Antineoplastic Agents, Phytogenic; Artemia; Candida albicans; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Mexico; Mice; Microbial Sensitivity Tests; Plants, Medicinal; Podophyllotoxin; Rats	1993
Cell-based screen for identification of inhibitors of tubulin polymerization. Journal of natural products, 1996, Volume: 59, Issue:12 Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Formazans; Glioma; Rats; Tubulin; Tumor Cells, Cultured	1996
Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells. Molecular pharmacology, 1997, Volume: 52, Issue:3 Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP-Binding Cassette Transporters; Cells, Cultured; Culture Techniques; Drug Resistance, Neoplasm; Embryo, Mammalian; Estradiol; Glutathione; Humans; Isomerism; Kidney; Leukotriene C4; Membranes; Mice; Multidrug Resistance-Associated Proteins; Phenotype; Transfection; Vincristine	1997
Asymmetric synthesis of antimitotic combretadioxolane with potent antitumor activity against multi-drug resistant cells. Bioorganic & medicinal chemistry letters, 1998, Aug-04, Volume: 8, Issue:15 Topics: Animals; Antineoplastic Agents; Cell Division; Dioxolanes; Drug Resistance, Multiple; PC12 Cells; Rats	1998
Synthesis and evaluation of 4-deacetoxyagosterol A as an MDR-modulator. Bioorganic & medicinal chemistry letters, 2000, Nov-20, Volume: 10, Issue:22 Topics: Animals; Drug Resistance, Multiple; Porifera; Sterols; Tumor Cells, Cultured	2000
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Synthetic 2-aroylindole derivatives as a new class of potent tubulin-inhibitory, antimitotic agents. Journal of medicinal chemistry, 2001, Dec-20, Volume: 44, Issue:26 Topics: Allantois; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Biopolymers; Cattle; Chorion; Drug Screening Assays, Antitumor; G2 Phase; GTP Phosphohydrolases; Humans; In Vitro Techniques; Indoles; Melanoma; Mice; Mice, Nude; Mitosis; Structure-Activity Relationship; Transplantation, Heterologous; Tubulin; Tumor Cells, Cultured	2001
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
BPR0L075, a novel synthetic indole compound with antimitotic activity in human cancer cells, exerts effective antitumoral activity in vivo. Cancer research, 2004, Jul-01, Volume: 64, Issue:13 Topics: Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Cell Division; Cell Line, Tumor; Colchicine; Drug Screening Assays, Antitumor; G2 Phase; Humans; Indoles; KB Cells; Male; Mice; Mice, Nude; Microtubules; Mitochondria; Mitosis; Neoplasms; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Tubulin; Tubulin Modulators; Xenograft Model Antitumor Assays	2004
9-Benzylidene-naphtho[2,3-b]thiophen-4-ones as novel antimicrotubule agents-synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2006, Dec-28, Volume: 49, Issue:26 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Proliferation; Cell Survival; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Flow Cytometry; Humans; Inhibitory Concentration 50; K562 Cells; Leukemia P388; Mice; Molecular Structure; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	2006
Synthesis and SAR of [1,2,4]triazolo[1,5-a]pyrimidines, a class of anticancer agents with a unique mechanism of tubulin inhibition. Journal of medicinal chemistry, 2007, Jan-25, Volume: 50, Issue:2 Topics: Administration, Oral; Animals; Cell Proliferation; Female; Humans; Injections, Intravenous; Mice; Mice, Nude; Pyrimidines; Stereoisomerism; Structure-Activity Relationship; Triazoles; Tubulin Modulators; Xenograft Model Antitumor Assays	2007
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cattle; Cell Cycle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Humans; Magnetic Resonance Spectroscopy; Mitosis; Tubulin; Vinblastine	2007
[(2-Phenylindol-3-yl)methylene]propanedinitriles inhibit the growth of breast cancer cells by cell cycle arrest in G(2)/M phase and apoptosis. Bioorganic & medicinal chemistry, 2007, Dec-01, Volume: 15, Issue:23 Topics: Animals; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; G2 Phase; Humans; Indoles; Mammary Neoplasms, Experimental; Mice; Molecular Structure; Nitriles; Stereoisomerism; Structure-Activity Relationship; Tubulin	2007
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24 Topics: Anthracenes; Cell Cycle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Naphthalenes; Nocodazole; Podophyllotoxin; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators	2007
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions. Journal of medicinal chemistry, 2008, Feb-14, Volume: 51, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Benzopyrans; Caspases; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Indoles; Pyrroles; Structure-Activity Relationship; Tubulin Modulators	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Aroyl hydrazones of 2-phenylindole-3-carbaldehydes as novel antimitotic agents. Bioorganic & medicinal chemistry, 2008, Jun-15, Volume: 16, Issue:12 Topics: Antimitotic Agents; Benzoates; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Hydrazones; Indoles; Pyridines	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents. Journal of medicinal chemistry, 2008, Dec-25, Volume: 51, Issue:24 Topics: Anisoles; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Inhibitory Concentration 50; Models, Chemical; Naphthalenes; Neoplasms; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2008
Design, synthesis and biological evaluation of novel stilbene-based antitumor agents. Bioorganic & medicinal chemistry, 2009, Jan-15, Volume: 17, Issue:2 Topics: Amines; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Humans; Prodrugs; Solubility; Stilbenes; Structure-Activity Relationship; Tubulin	2009
10-(2-oxo-2-phenylethylidene)-10H-anthracen-9-ones as highly active antimicrotubule agents: synthesis, antiproliferative activity, and inhibition of tubulin polymerization. Journal of medicinal chemistry, 2009, Mar-12, Volume: 52, Issue:5 Topics: Anthracenes; Binding, Competitive; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; G2 Phase; Humans; Protein Binding; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety. European journal of medicinal chemistry, 2010, Volume: 45, Issue:8 Topics: Anthracenes; Antineoplastic Agents; Benzylidene Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Protein Multimerization; Protein Structure, Quaternary; Tubulin	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent. Journal of medicinal chemistry, 2011, Jan-13, Volume: 54, Issue:1 Topics: Animals; Biological Availability; Cell Line, Tumor; Cell Proliferation; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; G2 Phase; Humans; Indoles; Isonicotinic Acids; Mice; Mice, Nude; Models, Molecular; Neoplasm Transplantation; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Sulfonamides; Transplantation, Heterologous; Tubulin; Tubulin Modulators	2011
Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents. Journal of medicinal chemistry, 2011, Mar-10, Volume: 54, Issue:5 Topics: Antineoplastic Agents; Cell Line, Tumor; Chromones; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Naphthalenes; Protein Binding; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators	2011
Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents-synthesis, antiproliferative activity and inhibition of tubulin polymerization. Bioorganic & medicinal chemistry, 2011, Jul-15, Volume: 19, Issue:14 Topics: Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Microtubules; Molecular Structure; Schiff Bases; Stereoisomerism; Structure-Activity Relationship; Tubulin	2011
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. Journal of medicinal chemistry, 2011, Sep-08, Volume: 54, Issue:17 Topics: Anisoles; Aorta; Benzofurans; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Humans; Neovascularization, Physiologic; Structure-Activity Relationship; Tubulin Modulators	2011
5-Amino-2-aroylquinolines as highly potent tubulin polymerization inhibitors. Part 2. The impact of bridging groups at position C-2. Journal of medicinal chemistry, 2011, Dec-22, Volume: 54, Issue:24 Topics: Aminoquinolines; Angiogenesis Inhibitors; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Human Umbilical Vein Endothelial Cells; Humans; Hydroxyquinolines; Quinolines; Stilbenes; Structure-Activity Relationship; Sulfones; Tubulin Modulators	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents. Journal of medicinal chemistry, 2013, Jul-11, Volume: 56, Issue:13 Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Blood-Brain Barrier; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Survival; Drug Design; Drug Resistance, Neoplasm; HCT116 Cells; Humans; K562 Cells; MCF-7 Cells; Mice; Mice, Nude; Microtubules; Neoplasms; Polymerization; Sulfonamides; Tubulin; Tumor Burden; Xenograft Model Antitumor Assays	2013
Furanylazaindoles: potent anticancer agents in vitro and in vivo. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Animals; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Female; Heterocyclic Compounds, 2-Ring; HT29 Cells; Humans; Indoles; Inhibitory Concentration 50; Mice, Nude; Molecular Structure; Neoplasms; Polymerization; Sulfonamides; Tubulin; Xenograft Model Antitumor Assays	2013
Synthesis and biological evaluation of 6H-pyrido[2',1':2,3]imidazo[4,5-c]isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization. Bioorganic & medicinal chemistry, 2014, Jan-15, Volume: 22, Issue:2 Topics: Antimitotic Agents; Cell Cycle; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Imidazoles; Isoquinolines; Molecular Structure; Polymerization; Pyridines; Structure-Activity Relationship; Tubulin	2014
Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site. Journal of medicinal chemistry, 2014, Feb-27, Volume: 57, Issue:4 Topics: Animals; Cell Proliferation; Colchicine; Female; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Models, Molecular; Quinazolines; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Tubulin Modulators	2014
Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones. European journal of medicinal chemistry, 2014, Apr-22, Volume: 77 Topics: Antimitotic Agents; Benzophenones; Cell Line, Tumor; Cell Proliferation; Colchicine; Dose-Response Relationship, Drug; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; KB Cells; Molecular Structure; Polymerization; Structure-Activity Relationship; Tubulin	2014
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Guanidines; Hedgehog Proteins; Humans; M Phase Cell Cycle Checkpoints; Mice; Molecular Docking Simulation; Neoplasms; Polymerization; Protein Binding; Pyrroles; Signal Transduction; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2014
Concise syntheses of 7-anilino-indoline-N-benzenesulfonamides as antimitotic and vascular disrupting agents. Bioorganic & medicinal chemistry, 2014, Sep-01, Volume: 22, Issue:17 Topics: Antineoplastic Agents; Capillaries; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HT29 Cells; Humans; Indoles; KB Cells; Mitosis; Molecular Structure; Polymerization; Structure-Activity Relationship; Sulfonamides; Tubulin; Tubulin Modulators	2014
Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Chalcones; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Fluorescence; G2 Phase Cell Cycle Checkpoints; Heterografts; Humans; Mice, Nude; Microtubules; Mitosis; Neoplasm Transplantation; Polymerization; Stereoisomerism; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2014
Antimitotic and antivascular activity of heteroaroyl-2-hydroxy-3,4,5-trimethoxybenzenes. Bioorganic & medicinal chemistry, 2015, Aug-01, Volume: 23, Issue:15 Topics: Angiogenesis Inhibitors; Antimitotic Agents; Benzene; Binding Sites; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Colchicine; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; HT29 Cells; Human Umbilical Vein Endothelial Cells; Humans; Inhibitory Concentration 50; Structure-Activity Relationship; Tubulin Modulators	2015
N-Sulfonyl-aminobiaryls as Antitubulin Agents and Inhibitors of Signal Transducers and Activators of Transcription 3 (STAT3) Signaling. Journal of medicinal chemistry, 2015, Aug-27, Volume: 58, Issue:16 Topics: Antineoplastic Agents; Apoptosis; Binding, Competitive; Cell Line, Tumor; Colchicine; Humans; Phosphorylation; STAT3 Transcription Factor; Structure-Activity Relationship; Sulfonamides; Tubulin Modulators	2015
An Orally Bioavailable, Indole-3-glyoxylamide Based Series of Tubulin Polymerization Inhibitors Showing Tumor Growth Inhibition in a Mouse Xenograft Model of Head and Neck Cancer. Journal of medicinal chemistry, 2015, Dec-10, Volume: 58, Issue:23 Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Proliferation; Drug Screening Assays, Antitumor; Head and Neck Neoplasms; Heterografts; Humans; Indoles; Male; Mice; Mice, Nude; Microtubules; Neoplasm Transplantation; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2015
Discovery of novel 2-phenyl-imidazo[1,2-a]pyridine analogues targeting tubulin polymerization as antiproliferative agents. European journal of medicinal chemistry, 2016, Apr-13, Volume: 112 Topics: Antineoplastic Agents; Cell Proliferation; Colchicine; Crystallography, X-Ray; HeLa Cells; Humans; Imidazoles; Models, Molecular; Neoplasms; Pyridines; Tubulin; Tubulin Modulators	2016
Resistance mechanisms and cross-resistance for a pyridine-pyrimidine amide inhibitor of microtubule polymerization. Bioorganic & medicinal chemistry letters, 2019, 07-01, Volume: 29, Issue:13 Topics: Amides; Humans; Microtubules; Polymerization; Pyridines; Pyrimidines	2019
A Multipronged Approach Establishes Covalent Modification of β-Tubulin as the Mode of Action of Benzamide Anti-cancer Toxins. Journal of medicinal chemistry, 2020, 11-25, Volume: 63, Issue:22 Topics: Antineoplastic Agents; Benzamides; Binding Sites; Colchicine; Humans; Lung Neoplasms; Microtubules; Protein Conformation; Small Cell Lung Carcinoma; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2020
Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR. European journal of medicinal chemistry, 2022, Jan-05, Volume: 227 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chalcones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indoles; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Structure-Activity Relationship; Thioredoxin-Disulfide Reductase; Tubulin; Tubulin Modulators	2022
Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis. Journal of medicinal chemistry, 2022, 03-24, Volume: 65, Issue:6 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Ferroptosis; Humans; Microtubules; Neoplasms; Stilbenes	2022