vincaleukoblastine and betulin

vincaleukoblastine has been researched along with betulin* in 1 studies

Other Studies

1 other study(ies) available for vincaleukoblastine and betulin

ArticleYear
Design, Synthesis, and Cancer Cell Growth Inhibitory Activity of Triphenylphosphonium Derivatives of the Triterpenoid Betulin.
    Journal of natural products, 2017, 08-25, Volume: 80, Issue:8

    A series of new triphenylphosphonium (TPP) derivatives of the triterpenoid betulin (1, 3-lup-20(29)-ene-3β,28-diol) have been synthesized and evaluated for cytotoxic effects against human breast cancer (MCF-7), prostate adenocarcinoma (PC-3), vinblastine-resistant human breast cancer (MCF-7/Vinb), and human skin fibroblast (HSF) cells. The TPP moiety was applied as a carrier group through the acyl linker at the 28- or 3- and 28-positions of betulin to promote cellular and mitochondrial accumulation of the resultant compounds. A structure-activity relationship study has revealed the essential role of the TPP group in the biological properties of the betulin derivatives produced. The present results showed that a conjugate of betulin with TPP (3) enhanced antiproliferative activity toward vinblastine-resistant MCF-7 cells, with an IC

    Topics: Breast Neoplasms; Cell Line, Tumor; Drug Design; Humans; Inhibitory Concentration 50; MCF-7 Cells; Mitochondria; Molecular Structure; Organophosphorus Compounds; Structure-Activity Relationship; Triterpenes

2017
chemdatabank.com