Page last updated: 2024-08-21

vinblastine and vincristine

vinblastine has been researched along with vincristine in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-19903 (7.32)18.7374
1990's8 (19.51)18.2507
2000's17 (41.46)29.6817
2010's13 (31.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boutin, JA; Cudennec, CA; Hautefaye, P; Lavielle, G; Pierré, A; Schaeffer, C1
Ishikawa, T; Keppler, D; Klünemann, C; Müller, M; Schaub, T1
Hansch, C; Khwaja, TA; Selassie, CD1
Duffel, MW; Elmarakby, SA; Rosazza, JP1
Duffel, MW; Elmarakby, SA; Goswami, A; Rosazza, JP; Sariaslani, FS1
Atassi, G; Bhushana Rao, KS; Collard, MP; Dejonghe, JP; Hannart, JA; Trouet, A1
Chai, H; Cruz, JG; Hernández, L; Mar, W; Novelo, M; Pereda-Miranda, R; Pezzuto, JM1
Almquist, KC; Cole, SP; Deeley, RG; Loe, DW1
Barrows, LR; Ireland, CM; Kokoshka, JM1
Chang, CJ; McLaughlin, JL; Oberlies, NH1
Ahn, SH; Duffel, MW; Rosazza, JP1
Hargrove, P; Kim, RB; Lan, LB; Lecureur, V; Schuetz, EG; Schuetz, JD; Sun, D1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA1
Borchardt, RT; Horie, K; Tang, F2
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M1
Gibbons, S; Kaatz, GW; Zloh, M1
Jolivette, LJ; Ward, KW1
Chattopadhyay, SK; Garg, A; Kaur, T; Khanuja, SP; Maulik, PR; Pal, A1
Burkett, BA; Chan, KF; Chan, TH; Chow, LM; Wong, IL; Zhao, Y1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Copper, JE; Gangjee, A; Smith, CD; Yu, J1
Attardo, G; Bubenick, M; Cai, SX; Crogan-Grundy, C; Denis, R; Drewe, J; Gourdeau, H; Jiang, S; Kasibhatla, S; Kemnitzer, W; Labreque, D; Lamothe, S; Tseng, B; Zhang, H1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Budde, C; Chen, X; Frank, AJ; Friedrich, T; Johnson, R; Leyhane, AJ; Liu, L; Manning, DD; Peace, D; Ralph, JM; Scott, IL; Stevens, JM; Surman, MD; Voss, ME; Wolf, M; Xie, D1
Hirasawa, Y; Hirata, T; Hosoya, T; Koyama, K; Kusumawati, I; Morita, H; Rahman, A; Shiro, M; Zaima, K; Zaini, NC1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Benfenati, E; Raska, I; Toropov, AA; Toropova, AP1
Biagini, GA; Chandramohanadas, R; Darling, C; DeGrado, WF; Diamond, SL; Fisher, N; Greenbaum, DC; Jing, H; Jo, H; Lucumi, E; Napper, AD; Shone, AE; Ward, SA1
Chen, X; Lin, X; Skolnik, S; Wang, J1
Gangjee, A; Keller, SN; Namjoshi, OA; Smith, CD1
Chalmers, DK; Chaplin, JH; Charman, SA; Flynn, BL; Gill, GS; Grobelny, DW; Hamel, E; Jung, MK; Kostewicz, E; Kremmidiotis, G; Lavranos, TC; Leske, AF; Morizzi, J; Paul, D; Shackleford, DM1
Boger, DL; Duncan, KK; Gotoh, H; Robertson, WM1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Cheng, YY; Huang, LJ; Kuo, SC; Lee, KH; Lin, HY; Liu, CY; Tsai, MT; Wu, TS; Yang, JS1
Avery, VM; Sykes, ML1
Chao, SH; Chen, CH; Kakadiya, R; Lee, TC; Lin, YW; Ou, TH; Su, TL; Suman, S; Tala, KS; Tala, SD; Tsai, TH; Wu, MH1
Alfonsi, R; Bai, R; Bolognesi, A; Brancale, A; Coluccia, A; Di Marcotullio, L; Dondio, G; Famiglini, V; Gulino, A; Hamel, E; La Regina, G; Lavia, P; Mazzoccoli, C; Mercurio, C; Miele, A; Nalli, M; Novellino, E; Passacantilli, S; Pelliccia, S; Rensen, WM; Ruggieri, V; Silvestri, R; Sisinni, L; Varasi, M; Vultaggio, S1
Burckhardt, G; Flörl, S; Hagos, Y; Kühne, A; Marada, VV1

Reviews

1 review(s) available for vinblastine and vincristine

ArticleYear
Approaches to protozoan drug discovery: phenotypic screening.
    Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20

    Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi

2013

Other Studies

40 other study(ies) available for vinblastine and vincristine

ArticleYear
New alpha-amino phosphonic acid derivatives of vinblastine: chemistry and antitumor activity.
    Journal of medicinal chemistry, 1991, Volume: 34, Issue:7

    Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chemical Phenomena; Chemistry; Leukemia P388; Mice; Mice, Inbred DBA; Organophosphonates; Structure-Activity Relationship; Vinblastine

1991
ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.
    The Journal of biological chemistry, 1990, Nov-05, Volume: 265, Issue:31

    Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Cell Fractionation; Cell Membrane; Glutathione; Kinetics; Leukotriene E4; Liver; Male; Models, Biological; Rats; Rats, Inbred Strains; Sialic Acids; SRS-A

1990
Structure-activity relationships of antineoplastic agents in multidrug resistance.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:7

    Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured

1990
In vitro metabolic transformations of vinblastine: oxidations catalyzed by human ceruloplasmin.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:9

    Topics: Biotransformation; Catalysis; Cell Line; Ceruloplasmin; Humans; Leukemia, T-Cell; Oxidation-Reduction; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine

1989
In vitro metabolic transformations of vinblastine: oxidations catalyzed by peroxidase.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:3

    Topics: Animals; Antineoplastic Agents, Phytogenic; Chemical Phenomena; Chemistry; Drug Screening Assays, Antitumor; Horseradish Peroxidase; Humans; Hydrogen Peroxide; Male; Mice; Oxidation-Reduction; Oxygen Isotopes; Tumor Cells, Cultured; Vinblastine; Vinca Alkaloids

1989
Vinblastin-23-oyl amino acid derivatives: chemistry, physicochemical data, toxicity, and antitumor activities against P388 and L1210 leukemias.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:8

    Topics: Animals; Antineoplastic Agents, Phytogenic; Female; Lethal Dose 50; Leukemia L1210; Leukemia P388; Mice; Mice, Inbred DBA; Structure-Activity Relationship; Vinblastine; Vincristine; Vindesine

1985
Cytotoxic constituents from Hyptis verticillata.
    Journal of natural products, 1993, Volume: 56, Issue:10

    Topics: Animals; Antineoplastic Agents, Phytogenic; Artemia; Candida albicans; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Mexico; Mice; Microbial Sensitivity Tests; Plants, Medicinal; Podophyllotoxin; Rats

1993
ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids.
    The Journal of biological chemistry, 1996, Apr-19, Volume: 271, Issue:16

    Topics: Adenosine Triphosphate; Animals; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Acids and Salts; Binding, Competitive; Biological Transport; Carcinoma, Small Cell; Cell Line; Cell Membrane; Epitopes; Estradiol; Glucuronates; HeLa Cells; Humans; Kinetics; Leukotriene C4; Lung Neoplasms; Mice; Protein Conformation; Recombinant Proteins; Transfection; Tumor Cells, Cultured

1996
Cell-based screen for identification of inhibitors of tubulin polymerization.
    Journal of natural products, 1996, Volume: 59, Issue:12

    Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Formazans; Glioma; Rats; Tubulin; Tumor Cells, Cultured

1996
Structure-activity relationships of diverse Annonaceous acetogenins against multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.
    Journal of medicinal chemistry, 1997, Jun-20, Volume: 40, Issue:13

    Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Furans; Humans; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured

1997
Oxidations of vincristine catalyzed by peroxidase and ceruloplasmin.
    Journal of natural products, 1997, Volume: 60, Issue:11

    Topics: Antineoplastic Agents, Phytogenic; Biotransformation; Ceruloplasmin; Chromatography, Thin Layer; Drug Screening Assays, Antitumor; Humans; Leukemia, T-Cell; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Peroxidases; Spectrophotometry, Infrared; Vinblastine; Vincristine

1997
Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein.
    Molecular pharmacology, 2000, Volume: 57, Issue:1

    Topics: Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Humans; Karyotyping; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Sequence Homology, Amino Acid

2000
Rational use of in vitro P-glycoprotein assays in drug discovery.
    The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2

    Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera

2001
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
    Pharmaceutical research, 2002, Volume: 19, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genes, MDR; Humans; Intestinal Mucosa; Transfection

2002
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
    Pharmaceutical research, 2002, Volume: 19, Issue:6

    Topics: Animals; Caco-2 Cells; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Mitochondrial Proteins; Multidrug Resistance-Associated Protein 2; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Transfection; Vinblastine

2002
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
    Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity

2004
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates.
    Bioorganic & medicinal chemistry letters, 2004, Feb-23, Volume: 14, Issue:4

    Topics: Anti-Bacterial Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Membrane; Drug Resistance, Microbial; Drug Resistance, Multiple; Ligands; Models, Molecular

2004
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure.
    Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7

    Topics: Algorithms; Animals; Dogs; Haplorhini; Humans; Pharmaceutical Preparations; Pharmacokinetics; Rats; Species Specificity; Tissue Distribution

2005
Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities.
    Bioorganic & medicinal chemistry letters, 2006, May-01, Volume: 16, Issue:9

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Concanavalin A; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Immunologic Factors; Lymphocytes; Models, Molecular; Molecular Conformation; Taxoids; Taxus; Vinblastine; Vincristine

2006
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
    Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23

    Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; Apigenin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Dimerization; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Paclitaxel; Polyethylene Glycols; Structure-Activity Relationship; Vinblastine

2006
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Discovery of novel antitumor antimitotic agents that also reverse tumor resistance.
    Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cattle; Cell Cycle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Humans; Magnetic Resonance Spectroscopy; Mitosis; Tubulin; Vinblastine

2007
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.
    Journal of medicinal chemistry, 2008, Feb-14, Volume: 51, Issue:3

    Topics: Antineoplastic Agents; Apoptosis; Benzopyrans; Caspases; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Indoles; Pyrroles; Structure-Activity Relationship; Tubulin Modulators

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Synthesis and SAR of vinca alkaloid analogues.
    Bioorganic & medicinal chemistry letters, 2009, Feb-15, Volume: 19, Issue:4

    Topics: Animals; Antineoplastic Agents, Phytogenic; Disease Models, Animal; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Leukemia P388; Mice; Molecular Structure; Structure-Activity Relationship; Vinblastine; Vinca Alkaloids; Vincristine

2009
Biscarpamontamines A and B, an aspidosperma-iboga bisindole alkaloid and an aspidosperma-aspidosperma bisindole alkaloid, from Tabernaemontana sphaerocarpa.
    Journal of natural products, 2009, Volume: 72, Issue:9

    Topics: Antineoplastic Agents, Phytogenic; Aspidosperma; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Indole Alkaloids; Indonesia; Molecular Structure; Plant Stems; Plants, Medicinal; Tabernaemontana

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:4

    Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water

2010
Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Animals; Antimalarials; Drug Resistance, Multiple; Molecular Structure; Parasitic Sensitivity Tests; Plasmodium falciparum

2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity

2011
2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance.
    Bioorganic & medicinal chemistry, 2011, Jul-15, Volume: 19, Issue:14

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Mitosis; Molecular Structure; Pyrimidines; Pyrroles; Stereoisomerism; Structure-Activity Relationship

2011
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties.
    Journal of medicinal chemistry, 2011, Sep-08, Volume: 54, Issue:17

    Topics: Anisoles; Aorta; Benzofurans; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Humans; Neovascularization, Physiologic; Structure-Activity Relationship; Tubulin Modulators

2011
10'-Fluorovinblastine and 10'-Fluorovincristine: Synthesis of a Key Series of Modified Vinca Alkaloids.
    ACS medicinal chemistry letters, 2011, Dec-08, Volume: 2, Issue:12

    Topics:

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead.
    Bioorganic & medicinal chemistry letters, 2013, Sep-15, Volume: 23, Issue:18

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Pyrrolidines; Quinolones; Structure-Activity Relationship

2013
Design and synthesis of potent antitumor water-soluble phenyl N-mustard-benzenealkylamide conjugates via a bioisostere approach.
    European journal of medicinal chemistry, 2014, Apr-09, Volume: 76

    Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; In Situ Nick-End Labeling; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Nude; Mustard Compounds; Rats; Spectrometry, Mass, Electrospray Ionization

2014
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.
    Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Guanidines; Hedgehog Proteins; Humans; M Phase Cell Cycle Checkpoints; Mice; Molecular Docking Simulation; Neoplasms; Polymerization; Protein Binding; Pyrroles; Signal Transduction; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2014
Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.
    European journal of medicinal chemistry, 2015, Mar-06, Volume: 92

    Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Humans; Liver-Specific Organic Anion Transporter 1; Molecular Structure; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Peptides; Solute Carrier Organic Anion Transporter Family Member 1B3

2015