Page last updated: 2024-08-21

vinblastine and paclitaxel

vinblastine has been researched along with paclitaxel in 80 studies

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (2.50)	18.2507
2000's	40 (50.00)	29.6817
2010's	38 (47.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Barrows, LR; Ireland, CM; Kokoshka, JM	1
Baeuerle, PA; Baichwal, V; Beckmann, H; Case, C; Clark, DL; Farrell, RP; Jaen, JC; Learned, RM; Li, A; Medina, JC; Roche, D; Rosen, T; Shan, B	1
Hargrove, P; Kim, RB; Lan, LB; Lecureur, V; Schuetz, EG; Schuetz, JD; Sun, D	1
Corbett, TH; Edelstein, M; Hazeldine, ST; Horwitz, JP; Kushner, J; Palomino, E; Paluch, J; Polin, L; White, K	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ	2
Barr, KJ; Claiborne, A; Credo, RB; Fitzgerald, M; Frost, D; Gehrke, L; Gwaltney, SL; Hui, YH; Kim, KH; Kovar, P; Lee, J; Li, Q; Liu, G; Marsh, K; Ng, SC; Nukkala, MA; Rosenberg, S; Sham, HL; Tahir, SK; Warner, RB; Woods, KW; Zielinski, NA	1
Thakker, DR; Troutman, MD	1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Gibbons, S; Kaatz, GW; Zloh, M	1
Bacherikov, VA; Chen, CH; Chou, TC; Dong, HJ; Lin, YW; Su, TL; Tsai, TJ	1
Beney, C; Boumendjel, A; Deka, N; Dumontet, C; Hadjeri, M; Lawson, MA; Peiller, EL	1
Attardo, G; Blais, C; Bouffard, D; Cai, SX; Denis, R; Drewe, J; Gourdeau, H; Herich, J; Jia, S; Jiang, S; Kasibhatla, S; Kemnitzer, W; Labreque, D; Lamothe, S; Meerovitch, K; Rej, R; Storer, R; Tseng, B; Wang, Y; Zhang, H; Zhao, J	1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Bacherikov, VA; Chen, CH; Chou, TC; Lin, YW; Liu, LF; Su, TL; Tsai, TJ; Zhang, X	1
Aspland, SE; Ballatore, C; Castellino, AJ; Castillo, R; Desharnais, J; Eustaquio, T; Goelet, P; Guo, Z; Li, Q; Nelson, D; Newman, MJ; Sun, C	1
Burkett, BA; Chan, KF; Chan, TH; Chow, LM; Wong, IL; Zhao, Y	1
Cai, X; Duan, JX; Hart, C; Lan, L; Matteucci, M; Meng, F	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
C-Gaudreault, R; Desjardins, M; Fortin, JS; Lacroix, J; Patenaude, A; Petitclerc, E	1
Copper, JE; Gangjee, A; Smith, CD; Yu, J	1
Bremner, JB; Locke, JM; Pyne, SG; Ranson, M; Vine, KL	1
Henriquez, FL; Ingram, PR; Muench, SP; Rice, DW; Roberts, CW	1
Andriantsiferana, R; Birkinshaw, C; Brodie, P; Kingston, DG; Miller, JS; Murphy, BT; Randrianjanaka, LM; Rasamison, VE; Slebodnick, C; Suh, EM; TenDyke, K	1
Attardo, G; Bubenick, M; Cai, SX; Crogan-Grundy, C; Denis, R; Drewe, J; Gourdeau, H; Jiang, S; Kasibhatla, S; Kemnitzer, W; Labreque, D; Lamothe, S; Tseng, B; Zhang, H	1
Chen, GY; Fong, WF; Globisch, C; Hu, YJ; Shen, XL; Tse, AK; Wiese, M; Yu, ZL; Zhu, GY	1
Barraja, P; Basso, G; Cirrincione, G; Dall'acqua, F; Dattolo, G; Diana, P; Martorana, A; Montalbano, A; Salvador, A; Vedaldi, D; Viola, G	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chen, YT; Chou, TC; Kakadiya, R; Kapuriya, K; Kapuriya, N; Lee, TC; Naliapara, Y; Shah, A; Su, TL; Tsai, TH; Wu, YT; Zhang, X	1
Fong, WF; Fu, LC; Hu, YJ; Huang, XA; Lu, HL; Shen, XL; Zhang, YH	1
C-Gaudreault, R; Côté, MF; Fortin, JS; Lacroix, J; Petitclerc, E	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Chen, YT; Chou, TC; Dong, H; Kapuriya, K; Kapuriya, N; Lee, TC; Lee, WC; Naliapara, Y; Su, TL; Tsai, TH; Zhang, X	1
Cai, SX; Crogan-Grundy, C; Drewe, J; May, C; Tseng, B; Zhang, HZ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Cai, SX; Crogan-Grundy, C; Drewe, J; Jiang, S; Kasibhatla, S; Kemnitzer, W; Kuemmerle, J; Sirisoma, N; Tseng, B	1
Cai, SX; Drewe, J; Kasibhatla, S; Kemnitzer, W; Kuemmerle, J; Tseng, B; Zhang, HZ	1
Chou, TC; Dong, H; Kakadiya, R; Kapuriya, K; Kapuriya, N; Lee, PC; Lee, TC; Shah, A; Su, TL; Zhang, X	1
Bochenek, D; Gogler, A; Gruca, A; Grynkiewicz, G; Głowala-Kosińska, M; Krawczyk, Z; Rusin, A; Szeja, W; Zawisza, J	1
Bernard, P; Do, QT; Galmarini, CM; Joseph, B; Kozielski, F; Popowycz, F; Putey, A; Talapatra, SK	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Cai, SX; Crogan-Grundy, C; Drewe, J; Jiang, S; Kasibhatla, S; Kemnitzer, W; Sirisoma, N; Tseng, B	1
Benfenati, E; Raska, I; Toropov, AA; Toropova, AP	1
Chou, TC; Dong, H; Kakadiya, R; Kumar, A; Lee, TC; Narsinh, D; Shah, A; Su, TL; Zhang, X	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M	1
Chen, J; Dalton, JT; Li, CM; Li, W; Lu, Y; Meibohm, B; Miller, DD; Vaddady, PK; Wang, Z	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, CH; Chou, TC; Dong, H; Kakadiya, R; Kapuriya, N; Kumar, A; Lam, K; Lee, PC; Lee, TC; Marvania, B; Shah, A; Su, TL; Zhang, X	1
Chaniyara, R; Chou, TC; Dong, H; Kakadiya, R; Kapuriya, N; Lee, PC; Lee, TC; Marvania, B; Shah, A; Su, TL; Suman, S	1
Carlson, EM; Cheng, H; Du, H; Hu, Y; Jiang, Y; Lewis, BM; Littlefield, BA; Narayan, S; Seletsky, BM; Tendyke, K; Towle, MJ; Yu, MJ; Zhang, H; Zheng, W	1
Carlson, EM; Cheng, H; Condon, K; Du, H; Eckley, S; Hu, Y; Jiang, Y; Kumar, V; Lewis, BM; Littlefield, BA; Narayan, S; Saxton, P; Schuck, E; Seletsky, BM; Tendyke, K; Towle, MJ; Yu, MJ; Zhang, H; Zheng, W	1
Chaniyara, R; Chou, TC; Dong, H; Kakadiya, R; Lee, PC; Lee, TC; Marvania, B; Shah, A; Su, TL; Suman, S	1
Chen, J; Dalton, JT; Li, CM; Li, W; Lu, Y; Miller, DD; Mohler, ML; Wang, Z	1
C-Gaudreault, R; Côté, MF; Fortin, S; Kotra, LP; Lacroix, J; Moreau, E; Petitclerc, E; Wei, L	1
Baraldi, PG; Basso, G; Bortolozzi, R; Brancale, A; Hamel, E; Ricci, A; Romagnoli, R; Viola, G	1
Gangjee, A; Keller, SN; Namjoshi, OA; Smith, CD	1
Chalmers, DK; Chaplin, JH; Charman, SA; Flynn, BL; Gill, GS; Grobelny, DW; Hamel, E; Jung, MK; Kostewicz, E; Kremmidiotis, G; Lavranos, TC; Leske, AF; Morizzi, J; Paul, D; Shackleford, DM	1
Côté, MF; Fortin, S; Gaudreault, RC; Kotra, LP; Lacroix, J; Moreau, E; Petitclerc, E; Wei, L	1
Balzarini, J; Baraldi, PG; Basso, G; Bortolozzi, R; Brancale, A; Fu, XH; Hamel, E; Kimatrai Salvador, M; Li, J; Lopez Cara, C; Romagnoli, R; Viola, G; Zhang, SZ	1
Bai, R; Bolognesi, A; Brancale, A; Coluccia, A; Dondio, G; Ferlini, C; Gatti, V; Granata, I; Hamel, E; Iannitto, ML; La Regina, G; Lavecchia, A; Lavia, P; Maresca, B; Mariani, M; Mercurio, C; Novellino, E; Piscitelli, F; Porta, A; Rensen, W; Santoni, A; Silvestri, R; Soriani, A; Varasi, M	1
Delva, D; Ode, E; Patel, M; Shimada, K; Skouta, R; Stockwell, BR; Yang, WS	1
Chaniyara, R; Chen, CH; Chen, CW; Chou, TC; Dong, H; Kakadiya, R; Lee, PC; Lee, TC; Marvania, B; Shah, A; Su, TL; Tala, S	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Lama, R; Li, B; Sandhu, R; Su, B; Zhong, B	1
Baraldi, PG; Bassetto, M; Basso, G; Bortolozzi, R; Brancale, A; Camacho, ME; Hamel, E; Preti, D; Romagnoli, R; Salvador, MK; Tabrizi, MA; Viola, G	1
Bai, R; Brancale, A; Chen, F; Coluccia, A; Costa, B; Da Pozzo, E; Di Cesare, E; Dondio, G; Famiglini, V; Granata, I; Hamel, E; Iannitto, ML; La Regina, G; Lavia, P; Li, J; Maresca, B; Martini, C; Mercurio, C; Miranda Cona, M; Nalli, M; Ni, Y; Novellino, E; Pelliccia, S; Piscitelli, F; Porta, A; Reggio, A; Rensen, WM; Santoni, A; Silvestri, R; Soriani, A; Varasi, M; Vultaggio, S	1
Aghazadeh Tabrizi, M; Baraldi, PG; Bassetto, M; Basso, G; Bortolozzi, R; Brancale, A; Castagliuolo, I; Hamel, E; Kimatrai Salvador, M; Preti, D; Romagnoli, R; Viola, G	1
Ahn, S; Chen, J; Dalton, JT; Li, W; Miller, DD; Wang, J; Xiao, M	1
Brodie, PJ; Dai, Y; Goetz, M; Harinantenaina, L; Kingston, DG; Shen, Y; TenDyke, K	1
Avery, VM; Sykes, ML	1
Banuls, LM; Betancourt, T; Evdokimov, NM; Frolova, LV; Hamel, E; Hayden, K; Karki, M; Kiss, R; Kornienko, A; Lu, SL; Magedov, IV; Otero, I; Rastogi, SK; Rogelj, S; Romero, AE; Shuster, CB; Smith, WR	1
Alfonsi, R; Bai, R; Bolognesi, A; Brancale, A; Coluccia, A; Di Marcotullio, L; Dondio, G; Famiglini, V; Gulino, A; Hamel, E; La Regina, G; Lavia, P; Mazzoccoli, C; Mercurio, C; Miele, A; Nalli, M; Novellino, E; Passacantilli, S; Pelliccia, S; Rensen, WM; Ruggieri, V; Silvestri, R; Sisinni, L; Varasi, M; Vultaggio, S	1
Burckhardt, G; Flörl, S; Hagos, Y; Kühne, A; Marada, VV	1
Aksenov, AV; Aksenov, NA; Aksenova, IV; Brenner, AJ; Bryan, BA; Cavazos, DA; Correa, J; De Carvalho, A; Frolova, LV; Johnston, RK; Kiss, R; Kornienko, A; Lefranc, F; Magedov, IV; Mathieu, V; Nguyen, G; Pendleton, AL; Reisenauer, MR; Rogelj, S; Rubin, M; Smirnov, AN	1
Li, S; Li, Z; Meng, X; Pan, L; Su, B; Yang, S; Yu, S; Zhang, C; Zhong, B	1
Alfonsi, R; Bai, R; Bigogno, C; Brancale, A; Caraglia, M; Coluccia, A; Da Pozzo, E; Di Marcotullio, L; Dondio, G; Famiglini, V; Gulino, A; Hamel, E; La Regina, G; Lavia, P; Marinelli, L; Martini, C; Mazzoccoli, C; Mercurio, C; Miele, A; Monti, L; Nalli, M; Novellino, E; Passacantilli, S; Pelliccia, S; Porto, S; Ricci, B; Ruggieri, V; Santoni, A; Silvestri, R; Soriani, A; Varasi, M; Verrico, A; Vultaggio, S	1
Burth, P; Calixto, JB; Dasari, R; De Carvalho, A; De La Chapa, JJ; Dybdal-Hargreaves, NF; Evidente, A; Frolova, LV; Gautier, M; Glass, R; Gonzales, CB; Hague, F; Kälin, RE; Kiss, R; Kornienko, A; Mathieu, V; Medellin, DC; Middleton, KN; Munirathinam, G; Pelly, SC; Pillai, A; Rogelj, S; Rossato, MF; van Otterlo, WA; Volmar, MN	1

Reviews

2 review(s) available for vinblastine and paclitaxel

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
Approaches to protozoan drug discovery: phenotypic screening. Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20 Topics: Drug Discovery; Humans; Molecular Structure; Neglected Diseases; Phenotype; Plasmodium falciparum; Protozoan Infections; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi	2013

Other Studies

78 other study(ies) available for vinblastine and paclitaxel

Article	Year
Cell-based screen for identification of inhibitors of tubulin polymerization. Journal of natural products, 1996, Volume: 59, Issue:12 Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Formazans; Glioma; Rats; Tubulin; Tumor Cells, Cultured	1996
Novel antineoplastic agents with efficacy against multidrug resistant tumor cells. Bioorganic & medicinal chemistry letters, 1998, Oct-06, Volume: 8, Issue:19 Topics: Antineoplastic Agents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fluorobenzenes; Humans; Phenotype; Sulfonamides; Tumor Cells, Cultured	1998
Cloning and expression of murine sister of P-glycoprotein reveals a more discriminating transporter than MDR1/P-glycoprotein. Molecular pharmacology, 2000, Volume: 57, Issue:1 Topics: Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Humans; Karyotyping; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Sequence Homology, Amino Acid	2000
Design, synthesis, and biological evaluation of analogues of the antitumor agent, 2-(4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy)propionic acid (XK469). Journal of medicinal chemistry, 2001, May-24, Volume: 44, Issue:11 Topics: Animals; Antineoplastic Agents; Drug Design; Drug Screening Assays, Antitumor; Humans; Mice; Quinoxalines; Stereoisomerism; Structure-Activity Relationship; Transplantation, Heterologous; Tumor Cells, Cultured	2001
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors. Biochemical and biophysical research communications, 2001, Nov-30, Volume: 289, Issue:2 Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors	2001
Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent. Bioorganic & medicinal chemistry letters, 2002, Feb-11, Volume: 12, Issue:3 Topics: Animals; Antineoplastic Agents; Biological Availability; Drug Screening Assays, Antitumor; Humans; Indoles; Mice; Microtubules; Models, Molecular; Oxazoles; Polymers; Rats; Stereoisomerism; Tubulin; Tumor Cells, Cultured	2002
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharmaceutical research, 2003, Volume: 20, Issue:4 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans	2003
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharmaceutical research, 2003, Volume: 20, Issue:8 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics	2003
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
Inhibitors of multidrug resistance (MDR) have affinity for MDR substrates. Bioorganic & medicinal chemistry letters, 2004, Feb-23, Volume: 14, Issue:4 Topics: Anti-Bacterial Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Cell Membrane; Drug Resistance, Microbial; Drug Resistance, Multiple; Ligands; Models, Molecular	2004
Potent antitumor N-mustard derivatives of 9-anilinoacridine, synthesis and antitumor evaluation. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Amsacrine; Animals; Antineoplastic Agents; Breast Neoplasms; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; Injections, Intravenous; Mice; Mice, Nude; Nitrogen Mustard Compounds; Paclitaxel; Structure-Activity Relationship; Tumor Cells, Cultured; Vinblastine; Xenograft Model Antitumor Assays	2004
Antimitotic activity of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones. Journal of medicinal chemistry, 2004, Sep-23, Volume: 47, Issue:20 Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; G2 Phase; Humans; K562 Cells; Mitosis; Quinolones; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles	2004
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group. Journal of medicinal chemistry, 2004, Dec-02, Volume: 47, Issue:25 Topics: Antineoplastic Agents; Apoptosis; Benzopyrans; Biopolymers; Caspases; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Dioxoles; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Poly(ADP-ribose) Polymerases; Structure-Activity Relationship; Tubulin	2004
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
Potent antitumor 9-anilinoacridines and acridines bearing an alkylating N-mustard residue on the acridine chromophore: synthesis and biological activity. Journal of medicinal chemistry, 2006, Jun-15, Volume: 49, Issue:12 Topics: Acridines; Aminoacridines; Aniline Compounds; Animals; Antineoplastic Agents, Alkylating; Cell Line, Tumor; DNA; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Nitrogen Mustard Compounds; Structure-Activity Relationship; Transplantation, Heterologous	2006
Kinase-mediated trapping of bi-functional conjugates of paclitaxel or vinblastine with thymidine in cancer cells. Bioorganic & medicinal chemistry letters, 2006, Oct-01, Volume: 16, Issue:19 Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Delivery Systems; Drug Design; Humans; Microtubules; Neoplasm Proteins; Neoplasms; Paclitaxel; Protein Kinases; Structure-Activity Relationship; Substrate Specificity; Thymidine; Vinblastine	2006
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells. Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23 Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; Apigenin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Dimerization; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Paclitaxel; Polyethylene Glycols; Structure-Activity Relationship; Vinblastine	2006
Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles. Journal of medicinal chemistry, 2007, Mar-08, Volume: 50, Issue:5 Topics: Acetylene; Animals; Binding Sites; Binding, Competitive; Cattle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Indazoles; Radioligand Assay; Stilbenes; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2007
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site. Bioorganic & medicinal chemistry, 2007, Jul-01, Volume: 15, Issue:13 Topics: Antineoplastic Agents, Alkylating; Binding Sites; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colchicine; HT29 Cells; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Protein Binding; Proteins; Structure-Activity Relationship; Substrate Specificity; Tubulin; Urea	2007
Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cattle; Cell Cycle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Humans; Magnetic Resonance Spectroscopy; Mitosis; Tubulin; Vinblastine	2007
An investigation into the cytotoxicity and mode of action of some novel N-alkyl-substituted isatins. Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21 Topics: Antineoplastic Agents; Apoptosis; Biopolymers; Caspase 3; Caspase 7; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Isatin; Lymphocytes; Microtubules; Stereoisomerism; Structure-Activity Relationship; Tubulin	2007
Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3 Topics: Acanthamoeba; Acanthamoeba castellanii; Albendazole; Animals; Binding Sites; Colchicine; Dinitrobenzenes; Drug Resistance; Models, Molecular; Paclitaxel; Parasitic Sensitivity Tests; Sulfanilamides; Tubulin; Tubulin Modulators; Vinblastine	2008
Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest. Journal of natural products, 2008, Volume: 71, Issue:3 Topics: Antineoplastic Agents, Phytogenic; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Limonins; Madagascar; Molecular Conformation; Molecular Structure	2008
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions. Journal of medicinal chemistry, 2008, Feb-14, Volume: 51, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Benzopyrans; Caspases; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Indoles; Pyrroles; Structure-Activity Relationship; Tubulin Modulators	2008
Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Adenosine Triphosphatases; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Coumarins; Drug Resistance, Multiple; Humans; Molecular Structure; Neoplasms; Oxygen; Pyranocoumarins; Pyrans; Sensitivity and Specificity; Structure-Activity Relationship; Substrate Specificity	2008
Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I. Journal of medicinal chemistry, 2008, Apr-24, Volume: 51, Issue:8 Topics: Antineoplastic Agents; Caspases; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Magnetic Resonance Spectroscopy; Microscopy, Fluorescence; Mitosis; Polymers; Quinoxalines; Reactive Oxygen Species; Spectrophotometry, Infrared; Topoisomerase I Inhibitors; Tubulin	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Synthesis and biological activity of stable and potent antitumor agents, aniline nitrogen mustards linked to 9-anilinoacridines via a urea linkage. Bioorganic & medicinal chemistry, 2008, May-15, Volume: 16, Issue:10 Topics: Acridines; Amsacrine; Aniline Mustard; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Mice; Mice, Nude; Molecular Structure; Rats; Stereoisomerism; Urea; Xenograft Model Antitumor Assays	2008
Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells. Journal of natural products, 2008, Volume: 71, Issue:6 Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Marsdenia; Multidrug Resistance-Associated Proteins; Paclitaxel; Plants, Medicinal; Puromycin; Steroids; Vinblastine	2008
Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression. Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15 Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Humans; Molecular Structure; Structure-Activity Relationship; Thioredoxins; Urea	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Novel DNA-directed alkylating agents: design, synthesis and potent antitumor effect of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker. Bioorganic & medicinal chemistry, 2009, Feb-01, Volume: 17, Issue:3 Topics: Acridines; Animals; Antineoplastic Agents, Alkylating; Carbamates; Carbonates; Cell Line, Tumor; DNA; Dose-Response Relationship, Drug; Drug Design; Half-Life; Humans; Inhibitory Concentration 50; Male; Mice; Mice, Nude; Neoplasms; Rats; Xenograft Model Antitumor Assays	2009
Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers. Bioorganic & medicinal chemistry, 2009, Apr-01, Volume: 17, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Drug Discovery; Drug Screening Assays, Antitumor; Guanidines; Humans; Semicarbazides; Structure-Activity Relationship; Tubulin Modulators	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2: Structure-activity relationships of the 4-, 5-, 6-, 7- and 8-positions. Bioorganic & medicinal chemistry letters, 2009, Jul-01, Volume: 19, Issue:13 Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Quinolines; Structure-Activity Relationship	2009
Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chemistry, Pharmaceutical; Combinatorial Chemistry Techniques; Drug Design; Drug Evaluation, Preclinical; Humans; Infusions, Intravenous; Mice; Models, Chemical; Molecular Structure; Neoplasm Transplantation; Oxadiazoles; Solubility; Structure-Activity Relationship; Water	2009
Potent antitumor bifunctional DNA alkylating agents, synthesis and biological activities of 3a-aza-cyclopenta[a]indenes. Bioorganic & medicinal chemistry, 2009, Aug-01, Volume: 17, Issue:15 Topics: Animals; Antineoplastic Agents, Alkylating; Aza Compounds; Breast Neoplasms; Carcinoma; Cell Cycle; Cell Line, Tumor; Cell Survival; Cross-Linking Reagents; DNA; Female; Humans; Indenes; Mice; Mice, Nude; Neoplasms; Remission Induction; Structure-Activity Relationship; Xenograft Model Antitumor Assays	2009
Unsaturated genistein disaccharide glycoside as a novel agent affecting microtubules. Bioorganic & medicinal chemistry letters, 2009, Sep-01, Volume: 19, Issue:17 Topics: Antineoplastic Agents; Cell Line, Tumor; Disaccharides; Genistein; Glycosides; Humans; Microtubules; Tubulin Modulators	2009
Indolobenzazepin-7-ones and 6-, 8-, and 9-membered ring derivatives as tubulin polymerization inhibitors: synthesis and structure--activity relationship studies. Journal of medicinal chemistry, 2009, Oct-08, Volume: 52, Issue:19 Topics: Antineoplastic Agents; Benzazepines; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Indoles; Structure-Activity Relationship; Tubulin Modulators	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 9-oxo-9H-fluorene ring. Bioorganic & medicinal chemistry letters, 2010, Feb-01, Volume: 20, Issue:3 Topics: Amides; Antineoplastic Agents; Apoptosis; Caspases; Drug Discovery; Fluorenes; HCT116 Cells; High-Throughput Screening Assays; Humans; Structure-Activity Relationship	2010
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations. European journal of medicinal chemistry, 2010, Volume: 45, Issue:4 Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water	2010
Potent DNA-directed alkylating agents: Synthesis and biological activity of phenyl N-mustard-quinoline conjugates having a urea or hydrazinecarboxamide linker. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Animals; Antineoplastic Agents, Alkylating; Cell Proliferation; DNA; Drug Screening Assays, Antitumor; Humans; Hydrazines; Male; Mice; Mice, Nude; Molecular Structure; Neoplasm Transplantation; Neoplasms, Experimental; Quinolines; Rats; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; Urea	2010
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. European journal of medicinal chemistry, 2010, Volume: 45, Issue:11 Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity	2010
Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. Journal of medicinal chemistry, 2010, Oct-28, Volume: 53, Issue:20 Topics: Animals; Binding Sites; Cell Line, Tumor; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Imidazoles; Mice; Mice, Inbred C57BL; Models, Molecular; Neoplasm Transplantation; Protein Binding; Protein Multimerization; Solubility; Structure-Activity Relationship; Transplantation, Heterologous; Tubulin; Tubulin Modulators	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Design, synthesis, and biological evaluation of novel water-soluble N-mustards as potential anticancer agents. Bioorganic & medicinal chemistry, 2011, Jan-01, Volume: 19, Issue:1 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Limit of Detection; Male; Mice; Mice, Nude; Mustard Compounds; Rats; Rats, Sprague-Dawley; Solubility; Water; Xenograft Model Antitumor Assays	2011
Novel bifunctional alkylating agents, 5,10-dihydropyrrolo[1,2-b]isoquinoline derivatives, synthesis and biological activity. Bioorganic & medicinal chemistry, 2011, Jan-01, Volume: 19, Issue:1 Topics: Animals; Antineoplastic Agents, Alkylating; Cell Cycle; Cell Line, Tumor; Humans; Isoquinolines; Magnetic Resonance Spectroscopy; Mice; Mice, Nude; Xenograft Model Antitumor Assays	2011
Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility. Bioorganic & medicinal chemistry letters, 2011, Mar-15, Volume: 21, Issue:6 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cell Line, Tumor; Furans; Humans; Ketones; Mice; Structure-Activity Relationship; Xenograft Model Antitumor Assays	2011
Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo. Bioorganic & medicinal chemistry letters, 2011, Mar-15, Volume: 21, Issue:6 Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Drug Resistance, Neoplasm; Furans; Humans; Ketones; Mice; Mice, Inbred BALB C; Xenograft Model Antitumor Assays	2011
Design, synthesis and antitumor evaluation of phenyl N-mustard-quinazoline conjugates. Bioorganic & medicinal chemistry, 2011, Mar-15, Volume: 19, Issue:6 Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Design; Humans; Mice; Mice, Nude; Mustard Plant; Neoplasms; Quinazolines; Structure-Activity Relationship; Urea; Xenograft Model Antitumor Assays	2011
Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents. Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13 Topics: Administration, Oral; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cattle; Cell Line, Tumor; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Hydrophobic and Hydrophilic Interactions; Rats; Rats, Sprague-Dawley; Solubility; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Tubulin; Tubulin Modulators	2011
Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4. Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13 Topics: Angiogenesis Inhibitors; Animals; Arylsulfonates; Benzene Derivatives; Binding Sites; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Colchicine; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazolidines; Models, Molecular; Molecular Mimicry; Neovascularization, Physiologic; Quantitative Structure-Activity Relationship; Stilbenes; Transplantation, Heterologous; Tubulin Modulators	2011
Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents. Journal of medicinal chemistry, 2011, Jul-28, Volume: 54, Issue:14 Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caspase Inhibitors; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Microtubules; Mitosis; Models, Molecular; Protein Binding; Structure-Activity Relationship; Thiazoles; Tubulin Modulators	2011
2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance. Bioorganic & medicinal chemistry, 2011, Jul-15, Volume: 19, Issue:14 Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Mitosis; Molecular Structure; Pyrimidines; Pyrroles; Stereoisomerism; Structure-Activity Relationship	2011
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. Journal of medicinal chemistry, 2011, Sep-08, Volume: 54, Issue:17 Topics: Anisoles; Aorta; Benzofurans; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Humans; Neovascularization, Physiologic; Structure-Activity Relationship; Tubulin Modulators	2011
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships. European journal of medicinal chemistry, 2011, Volume: 46, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Antimitotic Agents; Benzenesulfonamides; Binding Sites; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Colchicine; Humans; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Sulfonamides; Xenograft Model Antitumor Assays	2011
One-pot synthesis and biological evaluation of 2-pyrrolidinyl-4-amino-5-(3',4',5'-trimethoxybenzoyl)thiazole: a unique, highly active antimicrotubule agent. European journal of medicinal chemistry, 2011, Volume: 46, Issue:12 Topics: Animals; Antineoplastic Agents; Caspase 3; Cell Line, Tumor; Cell Proliferation; Female; G2 Phase; HeLa Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Thiazoles; Tubulin; Tubulin Modulators	2011
Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability. Journal of medicinal chemistry, 2011, Dec-22, Volume: 54, Issue:24 Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Caspase 3; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Furans; Humans; In Vitro Techniques; Indoles; Injections, Intravenous; Male; Mice; Mice, Nude; Microsomes, Liver; Pyrroles; Solubility; Structure-Activity Relationship; Thiophenes; Tubulin Modulators	2011
Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency. ACS medicinal chemistry letters, 2012, Jan-12, Volume: 3, Issue:1 Topics:	2012
Synthesis and antitumor evaluation of novel benzo[d]pyrrolo[2,1-b]thiazole derivatives. European journal of medicinal chemistry, 2012, Volume: 53 Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; DNA; Humans; Inhibitory Concentration 50; Male; Mice; Thiazoles; Xenograft Model Antitumor Assays	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Identification of selective tubulin inhibitors as potential anti-trypanosomal agents. Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17 Topics: Amino Acid Sequence; Animals; Cattle; Cell Proliferation; Cells, Cultured; Fibroblasts; Humans; Models, Molecular; Molecular Sequence Data; Structural Homology, Protein; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African; Tubulin; Tubulin Modulators	2012
Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents. Bioorganic & medicinal chemistry, 2012, Dec-15, Volume: 20, Issue:24 Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Colchicine; HeLa Cells; Humans; Microtubules; Models, Molecular; Structure-Activity Relationship; Thiazoles; Tubulin	2012
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. Journal of medicinal chemistry, 2013, Jan-10, Volume: 56, Issue:1 Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 Enzyme Inhibitors; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazoles; Indoles; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice; Microsomes, Liver; Mitosis; Permeability; Polymerization; Pyridines; Reactive Oxygen Species; Rhabdomyosarcoma; Solubility; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2013
Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents. Journal of medicinal chemistry, 2013, Mar-28, Volume: 56, Issue:6 Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; ATP Binding Cassette Transporter, Subfamily B; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lymphocytes; Mice; Mitochondria; Models, Molecular; Protein Multimerization; Protein Structure, Quaternary; Pyridines; Thiophenes; Tubulin; Xenograft Model Antitumor Assays	2013
Discovery of 4-Aryl-2-benzoyl-imidazoles as tubulin polymerization inhibitor with potent antiproliferative properties. Journal of medicinal chemistry, 2013, Apr-25, Volume: 56, Issue:8 Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazoles; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2013
Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa. Journal of natural products, 2013, May-24, Volume: 76, Issue:5 Topics: Antineoplastic Agents, Phytogenic; Drimia; Drug Screening Assays, Antitumor; Female; Humans; Inhibitory Concentration 50; Isoflavones; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Steroids	2013
Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids. Journal of medicinal chemistry, 2013, Sep-12, Volume: 56, Issue:17 Topics: Alkaloids; Biological Products; Colchicine; HeLa Cells; Humans; Magnetic Resonance Spectroscopy; Spectrometry, Mass, Electrospray Ionization; Structure-Activity Relationship; Tubulin	2013
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Guanidines; Hedgehog Proteins; Humans; M Phase Cell Cycle Checkpoints; Mice; Molecular Docking Simulation; Neoplasms; Polymerization; Protein Binding; Pyrroles; Signal Transduction; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2014
Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds. European journal of medicinal chemistry, 2015, Mar-06, Volume: 92 Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Line; Humans; Liver-Specific Organic Anion Transporter 1; Molecular Structure; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Peptides; Solute Carrier Organic Anion Transporter Family Member 1B3	2015
Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells. Journal of medicinal chemistry, 2015, Mar-12, Volume: 58, Issue:5 Topics: Antineoplastic Agents; Cell Differentiation; Cells, Cultured; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fibroblasts; Humans; Hydroxamic Acids; Indoles; Neoplasms; Neoplastic Stem Cells; Structure-Activity Relationship	2015
Synthesis and biological evaluation of thiabendazole derivatives as anti-angiogenesis and vascular disrupting agents. Bioorganic & medicinal chemistry, 2015, Jul-01, Volume: 23, Issue:13 Topics: Angiogenesis Inhibitors; Anthelmintics; Cell Proliferation; Drug Repositioning; HCT116 Cells; Hep G2 Cells; Human Umbilical Vein Endothelial Cells; Humans; Structure-Activity Relationship; Thiabendazole; Tubulin; Tubulin Modulators	2015
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer. Journal of medicinal chemistry, 2015, Aug-13, Volume: 58, Issue:15 Topics: Animals; Cell Division; Cell Line, Tumor; Cytotoxicity, Immunologic; Drug Resistance, Neoplasm; Hedgehog Proteins; Humans; Indoles; Killer Cells, Natural; Mice; Mitosis; Neoplasms; NIH 3T3 Cells; Tubulin	2015
Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines. European journal of medicinal chemistry, 2015, Oct-20, Volume: 103 Topics: Amines; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cytostatic Agents; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Molecular Conformation; Polygonum; Pyrroles; Sesquiterpenes; Structure-Activity Relationship	2015