Page last updated: 2024-08-21

vinblastine and colchicine

vinblastine has been researched along with colchicine in 55 studies

Research

Studies (55)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	5 (9.09)	18.2507
2000's	30 (54.55)	29.6817
2010's	20 (36.36)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Hansch, C; Khwaja, TA; Selassie, CD	1
Edwards, ML; Stemerick, DM; Sunkara, PS	1
Chai, H; Cruz, JG; Hernández, L; Mar, W; Novelo, M; Pereda-Miranda, R; Pezzuto, JM	1
Barrows, LR; Ireland, CM; Kokoshka, JM	1
Goldbrunner, M; Loidl, G; Mannschreck, A; Polossek, T; von Angerer, E	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Barr, KJ; Claiborne, A; Credo, RB; Fitzgerald, M; Frost, D; Gehrke, L; Gwaltney, SL; Hui, YH; Kim, KH; Kovar, P; Lee, J; Li, Q; Liu, G; Marsh, K; Ng, SC; Nukkala, MA; Rosenberg, S; Sham, HL; Tahir, SK; Warner, RB; Woods, KW; Zielinski, NA	1
Ejima, A; Hashimoto, Y; Hirotani, K; Koiso, Y; Minami, M; Naito, H; Ohki, H; Ohsuki, S	1
Gerassimova, GK; Kakpakova, ES; Nigmatov, AG; Serebryakov, EP; Shtil, AA; Sidorova, TA; Stavrovskaya, AA	1
Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A	1
Thakker, DR; Troutman, MD	1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Attardo, G; Blais, C; Bouffard, D; Cai, SX; Denis, R; Drewe, J; Gourdeau, H; Herich, J; Jia, S; Jiang, S; Kasibhatla, S; Kemnitzer, W; Labreque, D; Lamothe, S; Meerovitch, K; Rej, R; Storer, R; Tseng, B; Wang, Y; Zhang, H; Zhao, J	1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Anderson, JT; Bennani, YL; Boozer, S; Brunden, KR; Crumrine, C; Danzig, J; Dent, T; Faga, L; Harrington, JJ; Hodnick, WF; Murphy, SM; Pawlowski, G; Perry, R; Raber, A; Rundlett, SE; Stricker-Krongrad, A; Ting, AE; Wang, J	1
Cai, X; Duan, JX; Hart, C; Lan, L; Matteucci, M; Meng, F	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
C-Gaudreault, R; Desjardins, M; Fortin, JS; Lacroix, J; Patenaude, A; Petitclerc, E	1
Copper, JE; Gangjee, A; Smith, CD; Yu, J	1
Globisch, C; Kassack, MU; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M	1
Kornienko, A; Magedov, IV; Manpadi, M; Przheval'skii, NM; Rogelj, S; Rozhkova, E; Slambrouck, SV; Steelant, WF	1
Henriquez, FL; Ingram, PR; Muench, SP; Rice, DW; Roberts, CW	1
Attardo, G; Bubenick, M; Cai, SX; Crogan-Grundy, C; Denis, R; Drewe, J; Gourdeau, H; Jiang, S; Kasibhatla, S; Kemnitzer, W; Labreque, D; Lamothe, S; Tseng, B; Zhang, H	1
Barraja, P; Basso, G; Cirrincione, G; Dall'acqua, F; Dattolo, G; Diana, P; Martorana, A; Montalbano, A; Salvador, A; Vedaldi, D; Viola, G	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
C-Gaudreault, R; Côté, MF; Fortin, JS; Lacroix, J; Petitclerc, E	1
Anderson, MB; Baichwal, V; Cai, SX; Drewe, J; Hoang, K; Hussain, R; Jessing, K; Jiang, S; Kasibhatla, S; Mather, GG; Pervin, A; Pleiman, CM; Sirisoma, N; Tseng, B; Willardsen, JA; Zhang, H	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M	1
Cai, SX; Crogan-Grundy, C; Drewe, J; May, C; Tseng, B; Zhang, HZ	1
Cai, SX; Drewe, J; Pervin, A; Sirisoma, N; Tseng, B	1
Barabasz, AF; Barta, TE; Foley, BE; Geng, L; Hall, SE; Hanson, GJ; Jenks, M; Ma, W; Rice, JW; Veal, J	1
Cai, SX; Crogan-Grundy, C; Drewe, J; Jiang, S; Kasibhatla, S; Kemnitzer, W; Nguyen, B; Sirisoma, N; Tseng, B	1
Cai, SX; Drewe, J; Kasibhatla, S; Kemnitzer, W; Kuemmerle, J; Tseng, B; Zhang, HZ	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M	1
Glen, RC; Lowe, R; Mitchell, JB	1
Chen, J; Dalton, JT; Li, CM; Li, W; Lu, Y; Meibohm, B; Miller, DD; Vaddady, PK; Wang, Z	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Chen, J; Dalton, JT; Li, CM; Li, W; Lu, Y; Miller, DD; Mohler, ML; Wang, Z	1
C-Gaudreault, R; Côté, MF; Fortin, S; Kotra, LP; Lacroix, J; Moreau, E; Petitclerc, E; Wei, L	1
Chalmers, DK; Chaplin, JH; Charman, SA; Flynn, BL; Gill, GS; Grobelny, DW; Hamel, E; Jung, MK; Kostewicz, E; Kremmidiotis, G; Lavranos, TC; Leske, AF; Morizzi, J; Paul, D; Shackleford, DM	1
Côté, MF; Fortin, S; Gaudreault, RC; Kotra, LP; Lacroix, J; Moreau, E; Petitclerc, E; Wei, L	1
Bai, R; Bolognesi, A; Brancale, A; Coluccia, A; Dondio, G; Ferlini, C; Gatti, V; Granata, I; Hamel, E; Iannitto, ML; La Regina, G; Lavecchia, A; Lavia, P; Maresca, B; Mariani, M; Mercurio, C; Novellino, E; Piscitelli, F; Porta, A; Rensen, W; Santoni, A; Silvestri, R; Soriani, A; Varasi, M	1
Delva, D; Ode, E; Patel, M; Shimada, K; Skouta, R; Stockwell, BR; Yang, WS	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Lama, R; Li, B; Sandhu, R; Su, B; Zhong, B	1
Bai, R; Brancale, A; Chen, F; Coluccia, A; Costa, B; Da Pozzo, E; Di Cesare, E; Dondio, G; Famiglini, V; Granata, I; Hamel, E; Iannitto, ML; La Regina, G; Lavia, P; Li, J; Maresca, B; Martini, C; Mercurio, C; Miranda Cona, M; Nalli, M; Ni, Y; Novellino, E; Pelliccia, S; Piscitelli, F; Porta, A; Reggio, A; Rensen, WM; Santoni, A; Silvestri, R; Soriani, A; Varasi, M; Vultaggio, S	1
Asthana, J; Chakraborty, TK; Gajula, PK; Panda, D	1
Ahn, S; Chen, J; Dalton, JT; Li, W; Miller, DD; Wang, J; Xiao, M	1
Alfonsi, R; Bai, R; Bolognesi, A; Brancale, A; Coluccia, A; Di Marcotullio, L; Dondio, G; Famiglini, V; Gulino, A; Hamel, E; La Regina, G; Lavia, P; Mazzoccoli, C; Mercurio, C; Miele, A; Nalli, M; Novellino, E; Passacantilli, S; Pelliccia, S; Rensen, WM; Ruggieri, V; Silvestri, R; Sisinni, L; Varasi, M; Vultaggio, S	1
Aleksandrova, NS; Astrat'ev, AA; Atamanenko, OP; Firgang, SI; Kiselyov, AS; Konyushkin, LD; Lagutina, NK; Palysaeva, NV; Sadchikova, NP; Semenov, RV; Semenov, VV; Semenova, MN; Sheremetev, AB; Stepanov, AI; Suponitsky, KY; Tyurin, AY	1
Asai, A; Ishii, H; Kuroiwa, K; Matsuno, K; Suzuki, Y	1
Alfonsi, R; Bai, R; Bigogno, C; Brancale, A; Caraglia, M; Coluccia, A; Da Pozzo, E; Di Marcotullio, L; Dondio, G; Famiglini, V; Gulino, A; Hamel, E; La Regina, G; Lavia, P; Marinelli, L; Martini, C; Mazzoccoli, C; Mercurio, C; Miele, A; Monti, L; Nalli, M; Novellino, E; Passacantilli, S; Pelliccia, S; Porto, S; Ricci, B; Ruggieri, V; Santoni, A; Silvestri, R; Soriani, A; Varasi, M; Verrico, A; Vultaggio, S	1

Other Studies

55 other study(ies) available for vinblastine and colchicine

Article	Year
Structure-activity relationships of antineoplastic agents in multidrug resistance. Journal of medicinal chemistry, 1990, Volume: 33, Issue:7 Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured	1990
Chalcones: a new class of antimitotic agents. Journal of medicinal chemistry, 1990, Volume: 33, Issue:7 Topics: Antineoplastic Agents; Cell Cycle; Chalcone; HeLa Cells; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Mitosis; Molecular Structure; Propiophenones; Structure-Activity Relationship	1990
Cytotoxic constituents from Hyptis verticillata. Journal of natural products, 1993, Volume: 56, Issue:10 Topics: Animals; Antineoplastic Agents, Phytogenic; Artemia; Candida albicans; Drug Screening Assays, Antitumor; Humans; Leukemia P388; Mexico; Mice; Microbial Sensitivity Tests; Plants, Medicinal; Podophyllotoxin; Rats	1993
Cell-based screen for identification of inhibitors of tubulin polymerization. Journal of natural products, 1996, Volume: 59, Issue:12 Topics: Animals; Brain Neoplasms; Bucladesine; Cell Differentiation; Drug Screening Assays, Antitumor; Formazans; Glioma; Rats; Tubulin; Tumor Cells, Cultured	1996
Inhibition of tubulin polymerization by 5,6-dihydroindolo[2,1-alpha]isoquinoline derivatives. Journal of medicinal chemistry, 1997, Oct-24, Volume: 40, Issue:22 Topics: Animals; Antineoplastic Agents; Cattle; Colchicine; Humans; Indoles; Isoquinolines; Magnetic Resonance Spectroscopy; Molecular Structure; Polymers; Protein Binding; Spectrophotometry, Infrared; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	1997
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Synthesis and biological evaluation of 2-indolyloxazolines as a new class of tubulin polymerization inhibitors. Discovery of A-289099 as an orally active antitumor agent. Bioorganic & medicinal chemistry letters, 2002, Feb-11, Volume: 12, Issue:3 Topics: Animals; Antineoplastic Agents; Biological Availability; Drug Screening Assays, Antitumor; Humans; Indoles; Mice; Microtubules; Models, Molecular; Oxazoles; Polymers; Rats; Stereoisomerism; Tubulin; Tumor Cells, Cultured	2002
Synthesis and mechanism of action of novel pyrimidinyl pyrazole derivatives possessing antiproliferative activity. Bioorganic & medicinal chemistry letters, 2002, Nov-04, Volume: 12, Issue:21 Topics: Antineoplastic Agents; Binding, Competitive; Colchicine; Drug Screening Assays, Antitumor; Humans; Indicators and Reagents; Lung Neoplasms; Microtubules; Protein Binding; Pyrazoles; Pyrimidines; Tubulin; Tubulin Modulators; Tumor Cells, Cultured	2002
Effects of isoprenoid analogues of SDB-ethylenediamine on multidrug resistant tumor cells alone and in combination with chemotherapeutic drugs. Journal of medicinal chemistry, 2002, Nov-21, Volume: 45, Issue:24 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bleomycin; Cell Line; Cricetinae; Cytarabine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Ethylenediamines; Fibroblasts; Humans; Polyenes; Rats; Structure-Activity Relationship; Terpenes; Tumor Cells, Cultured; Vinblastine	2002
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry, 2003, Apr-24, Volume: 46, Issue:9 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine	2003
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium. Pharmaceutical research, 2003, Volume: 20, Issue:8 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics	2003
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the 4-aryl group. Journal of medicinal chemistry, 2004, Dec-02, Volume: 47, Issue:25 Topics: Antineoplastic Agents; Apoptosis; Benzopyrans; Biopolymers; Caspases; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Dioxoles; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Poly(ADP-ribose) Polymerases; Structure-Activity Relationship; Tubulin	2004
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
Identification of novel and improved antimitotic agents derived from noscapine. Journal of medicinal chemistry, 2005, Nov-17, Volume: 48, Issue:23 Topics: Animals; Antineoplastic Agents; Biopolymers; Cell Line; Drug Screening Assays, Antitumor; G2 Phase; HeLa Cells; Humans; Mice; Microtubules; Noscapine; Stereoisomerism; Tubulin; Tubulin Modulators	2005
Potent antitubulin tumor cell cytotoxins based on 3-aroyl indazoles. Journal of medicinal chemistry, 2007, Mar-08, Volume: 50, Issue:5 Topics: Acetylene; Animals; Binding Sites; Binding, Competitive; Cattle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Indazoles; Radioligand Assay; Stilbenes; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2007
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site. Bioorganic & medicinal chemistry, 2007, Jul-01, Volume: 15, Issue:13 Topics: Antineoplastic Agents, Alkylating; Binding Sites; Blotting, Western; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colchicine; HT29 Cells; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Protein Binding; Proteins; Structure-Activity Relationship; Substrate Specificity; Tubulin; Urea	2007
Discovery of novel antitumor antimitotic agents that also reverse tumor resistance. Journal of medicinal chemistry, 2007, Jul-12, Volume: 50, Issue:14 Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cattle; Cell Cycle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Humans; Magnetic Resonance Spectroscopy; Mitosis; Tubulin; Vinblastine	2007
New functional assay of P-glycoprotein activity using Hoechst 33342. Bioorganic & medicinal chemistry, 2007, Dec-01, Volume: 15, Issue:23 Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluoresceins; Humans; Microscopy, Fluorescence; Molecular Structure; Principal Component Analysis; Time Factors	2007
Discovery and investigation of antiproliferative and apoptosis-inducing properties of new heterocyclic podophyllotoxin analogues accessible by a one-step multicomponent synthesis. Journal of medicinal chemistry, 2007, Oct-18, Volume: 50, Issue:21 Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 3-Ring; Humans; Lymphocytes; Podophyllotoxin; Pyrazoles; Stereoisomerism; Structure-Activity Relationship	2007
Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:3 Topics: Acanthamoeba; Acanthamoeba castellanii; Albendazole; Animals; Binding Sites; Colchicine; Dinitrobenzenes; Drug Resistance; Models, Molecular; Paclitaxel; Parasitic Sensitivity Tests; Sulfanilamides; Tubulin; Tubulin Modulators; Vinblastine	2008
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions. Journal of medicinal chemistry, 2008, Feb-14, Volume: 51, Issue:3 Topics: Antineoplastic Agents; Apoptosis; Benzopyrans; Caspases; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Indoles; Pyrroles; Structure-Activity Relationship; Tubulin Modulators	2008
Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I. Journal of medicinal chemistry, 2008, Apr-24, Volume: 51, Issue:8 Topics: Antineoplastic Agents; Caspases; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Magnetic Resonance Spectroscopy; Microscopy, Fluorescence; Mitosis; Polymers; Quinoxalines; Reactive Oxygen Species; Spectrophotometry, Infrared; Topoisomerase I Inhibitors; Tubulin	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Aromatic 2-chloroethyl urea derivatives and bioisosteres. Part 2: Cytocidal activity and effects on the nuclear translocation of thioredoxin-1, and the cell cycle progression. Bioorganic & medicinal chemistry, 2008, Aug-01, Volume: 16, Issue:15 Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Humans; Molecular Structure; Structure-Activity Relationship; Thioredoxins; Urea	2008
Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity. Journal of medicinal chemistry, 2008, Aug-14, Volume: 51, Issue:15 Topics: Animals; Apoptosis; Brain; Caspases; Cell Line, Tumor; Cell Proliferation; Enzyme Activation; Humans; Mice; Molecular Structure; Quinazolines; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21 Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship	2008
Discovery and structure-activity relationships of (2-(arylthio)benzylideneamino)guanidines as a novel series of potent apoptosis inducers. Bioorganic & medicinal chemistry, 2009, Apr-01, Volume: 17, Issue:7 Topics: Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Cell Line, Tumor; Drug Discovery; Drug Screening Assays, Antitumor; Guanidines; Humans; Semicarbazides; Structure-Activity Relationship; Tubulin Modulators	2009
Discovery of substituted N'-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay. Bioorganic & medicinal chemistry letters, 2009, May-15, Volume: 19, Issue:10 Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Drug Discovery; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Hydrazines; Structure-Activity Relationship; Tubulin Modulators	2009
Novel carbazole and acyl-indole antimitotics. Bioorganic & medicinal chemistry letters, 2009, Jun-01, Volume: 19, Issue:11 Topics: Antimitotic Agents; Carbazoles; Cell Line, Tumor; Colchicine; Drug Screening Assays, Antitumor; HSP90 Heat-Shock Proteins; Humans; Indoles; Tubulin	2009
Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the carboxamide group. Bioorganic & medicinal chemistry letters, 2009, Jun-01, Volume: 19, Issue:11 Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Line, Tumor; Drug Design; Drug Screening Assays, Antitumor; Fluorenes; HCT116 Cells; Humans; Pyrazoles; Structure-Activity Relationship	2009
Discovery of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers. 2. Identification of more aqueous soluble analogs as potential anticancer agents. Bioorganic & medicinal chemistry letters, 2009, Aug-01, Volume: 19, Issue:15 Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Chemistry, Pharmaceutical; Combinatorial Chemistry Techniques; Drug Design; Drug Evaluation, Preclinical; Humans; Infusions, Intravenous; Mice; Models, Chemical; Molecular Structure; Neoplasm Transplantation; Oxadiazoles; Solubility; Structure-Activity Relationship; Water	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. European journal of medicinal chemistry, 2010, Volume: 45, Issue:11 Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Discovery of novel 2-aryl-4-benzoyl-imidazoles targeting the colchicines binding site in tubulin as potential anticancer agents. Journal of medicinal chemistry, 2010, Oct-28, Volume: 53, Issue:20 Topics: Animals; Binding Sites; Cell Line, Tumor; Colchicine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Imidazoles; Mice; Mice, Inbred C57BL; Models, Molecular; Neoplasm Transplantation; Protein Binding; Protein Multimerization; Solubility; Structure-Activity Relationship; Transplantation, Heterologous; Tubulin; Tubulin Modulators	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Design, synthesis, and SAR studies of 4-substituted methoxylbenzoyl-aryl-thiazoles analogues as potent and orally bioavailable anticancer agents. Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13 Topics: Administration, Oral; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cattle; Cell Line, Tumor; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Hydrophobic and Hydrophilic Interactions; Rats; Rats, Sprague-Dawley; Solubility; Stereoisomerism; Structure-Activity Relationship; Thiazoles; Tubulin; Tubulin Modulators	2011
Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4. Journal of medicinal chemistry, 2011, Jul-14, Volume: 54, Issue:13 Topics: Angiogenesis Inhibitors; Animals; Arylsulfonates; Benzene Derivatives; Binding Sites; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Colchicine; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazolidines; Models, Molecular; Molecular Mimicry; Neovascularization, Physiologic; Quantitative Structure-Activity Relationship; Stilbenes; Transplantation, Heterologous; Tubulin Modulators	2011
Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties. Journal of medicinal chemistry, 2011, Sep-08, Volume: 54, Issue:17 Topics: Anisoles; Aorta; Benzofurans; Cell Proliferation; Cells, Cultured; Endothelium, Vascular; Humans; Neovascularization, Physiologic; Structure-Activity Relationship; Tubulin Modulators	2011
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships. European journal of medicinal chemistry, 2011, Volume: 46, Issue:11 Topics: Angiogenesis Inhibitors; Animals; Antimitotic Agents; Benzenesulfonamides; Binding Sites; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Colchicine; Humans; Models, Molecular; Molecular Conformation; Quantitative Structure-Activity Relationship; Sulfonamides; Xenograft Model Antitumor Assays	2011
Design and synthesis of 2-heterocyclyl-3-arylthio-1H-indoles as potent tubulin polymerization and cell growth inhibitors with improved metabolic stability. Journal of medicinal chemistry, 2011, Dec-22, Volume: 54, Issue:24 Topics: Administration, Oral; Animals; Antineoplastic Agents; Biological Availability; Caspase 3; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Furans; Humans; In Vitro Techniques; Indoles; Injections, Intravenous; Male; Mice; Mice, Nude; Microsomes, Liver; Pyrroles; Solubility; Structure-Activity Relationship; Thiophenes; Tubulin Modulators	2011
Identification of Simple Compounds with Microtubule-Binding Activity That Inhibit Cancer Cell Growth with High Potency. ACS medicinal chemistry letters, 2012, Jan-12, Volume: 3, Issue:1 Topics:	2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Identification of selective tubulin inhibitors as potential anti-trypanosomal agents. Bioorganic & medicinal chemistry letters, 2012, Sep-01, Volume: 22, Issue:17 Topics: Amino Acid Sequence; Animals; Cattle; Cell Proliferation; Cells, Cultured; Fibroblasts; Humans; Models, Molecular; Molecular Sequence Data; Structural Homology, Protein; Sulfonamides; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African; Tubulin; Tubulin Modulators	2012
Toward highly potent cancer agents by modulating the C-2 group of the arylthioindole class of tubulin polymerization inhibitors. Journal of medicinal chemistry, 2013, Jan-10, Volume: 56, Issue:1 Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 Enzyme Inhibitors; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazoles; Indoles; Liver Neoplasms; Membrane Potential, Mitochondrial; Mice; Microsomes, Liver; Mitosis; Permeability; Polymerization; Pyridines; Reactive Oxygen Species; Rhabdomyosarcoma; Solubility; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2013
A synthetic dolastatin 10 analogue suppresses microtubule dynamics, inhibits cell proliferation, and induces apoptotic cell death. Journal of medicinal chemistry, 2013, Mar-28, Volume: 56, Issue:6 Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Proliferation; Colchicine; Depsipeptides; Drug Interactions; Drug Resistance, Neoplasm; GTP Phosphohydrolases; HeLa Cells; Humans; JNK Mitogen-Activated Protein Kinases; Kinetochores; MCF-7 Cells; Microtubules; Mitosis; Protein Multimerization; Protein Structure, Quaternary; Tubulin; Vinblastine	2013
Discovery of 4-Aryl-2-benzoyl-imidazoles as tubulin polymerization inhibitor with potent antiproliferative properties. Journal of medicinal chemistry, 2013, Apr-25, Volume: 56, Issue:8 Topics: Cell Line, Tumor; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazoles; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2013
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer. Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15 Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Death; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Colchicine; Drug Screening Assays, Antitumor; Guanidines; Hedgehog Proteins; Humans; M Phase Cell Cycle Checkpoints; Mice; Molecular Docking Simulation; Neoplasms; Polymerization; Protein Binding; Pyrroles; Signal Transduction; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2014
A facile synthesis and microtubule-destabilizing properties of 4-(1H-benzo[d]imidazol-2-yl)-furazan-3-amines. European journal of medicinal chemistry, 2015, Apr-13, Volume: 94 Topics: 3T3 Cells; Animals; Antimitotic Agents; Antineoplastic Agents; Benzimidazoles; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Mice; Microtubules; Models, Molecular; Molecular Structure; Oxadiazoles; Sea Urchins; Structure-Activity Relationship	2015
Synthesis and Structure-Activity Relationship Study of 1-Phenyl-1-(quinazolin-4-yl)ethanols as Anticancer Agents. ACS medicinal chemistry letters, 2015, Mar-12, Volume: 6, Issue:3 Topics:	2015
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer. Journal of medicinal chemistry, 2015, Aug-13, Volume: 58, Issue:15 Topics: Animals; Cell Division; Cell Line, Tumor; Cytotoxicity, Immunologic; Drug Resistance, Neoplasm; Hedgehog Proteins; Humans; Indoles; Killer Cells, Natural; Mice; Mitosis; Neoplasms; NIH 3T3 Cells; Tubulin	2015