vestipitant and diphenyl

vestipitant has been researched along with diphenyl* in 1 studies

Other Studies

1 other study(ies) available for vestipitant and diphenyl

Article	Year
Application of LC-NMR and HR-NMR to the characterization of biphenyl impurities in the synthetic route development for vestipitant, a novel NK1 antagonist. Journal of pharmaceutical and biomedical analysis, 2010, Nov-02, Volume: 53, Issue:3 Vestipitant (1) is a novel NK1 antagonist currently under investigation for the treatment of CNS disorders and emesis. The first synthetic step comprised a Grignard synthesis. An impurity was identified and initially expected to be a symmetric biphenyl. This paper reports the work to synthesise the supposed structure and the spectroscopic analyses (LC-NMR and HR-NMR) to correctly identify the real structure and understand the chemical pathway of the impurity. Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drug Contamination; Fluorobenzenes; Magnetic Resonance Spectroscopy; Neurokinin-1 Receptor Antagonists; Piperidines	2010

Article

Year

Application of LC-NMR and HR-NMR to the characterization of biphenyl impurities in the synthetic route development for vestipitant, a novel NK1 antagonist.

Journal of pharmaceutical and biomedical analysis, 2010, Nov-02, Volume: 53, Issue:3

Vestipitant (1) is a novel NK1 antagonist currently under investigation for the treatment of CNS disorders and emesis. The first synthetic step comprised a Grignard synthesis. An impurity was identified and initially expected to be a symmetric biphenyl. This paper reports the work to synthesise the supposed structure and the spectroscopic analyses (LC-NMR and HR-NMR) to correctly identify the real structure and understand the chemical pathway of the impurity.

Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drug Contamination; Fluorobenzenes; Magnetic Resonance Spectroscopy; Neurokinin-1 Receptor Antagonists; Piperidines

2010