vestipitant has been researched along with diphenyl* in 1 studies
1 other study(ies) available for vestipitant and diphenyl
Article | Year |
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Application of LC-NMR and HR-NMR to the characterization of biphenyl impurities in the synthetic route development for vestipitant, a novel NK1 antagonist.
Vestipitant (1) is a novel NK1 antagonist currently under investigation for the treatment of CNS disorders and emesis. The first synthetic step comprised a Grignard synthesis. An impurity was identified and initially expected to be a symmetric biphenyl. This paper reports the work to synthesise the supposed structure and the spectroscopic analyses (LC-NMR and HR-NMR) to correctly identify the real structure and understand the chemical pathway of the impurity. Topics: Biphenyl Compounds; Chromatography, High Pressure Liquid; Drug Contamination; Fluorobenzenes; Magnetic Resonance Spectroscopy; Neurokinin-1 Receptor Antagonists; Piperidines | 2010 |