vernakalant and zinc-chloride

vernakalant has been researched along with zinc-chloride* in 1 studies

Other Studies

1 other study(ies) available for vernakalant and zinc-chloride

ArticleYear
A highly efficient asymmetric synthesis of vernakalant.
    Organic letters, 2014, May-16, Volume: 16, Issue:10

    A novel synthesis of vernakalant is described. Using inexpensive and readily available reagents, the key transformations involve (1) an efficient zinc-amine-promoted etherification, (2) a highly stereoselective enzyme-catalyzed dynamic asymmetric transamination to set up the two contiguous chiral centers in the cyclohexane ring, and (3) a pyrrolidine ring formation via alkyl-B(OH)2-catalyzed amidation and subsequent imide reduction.

    Topics: Amination; Amines; Anisoles; Catalysis; Chlorides; Cyclohexanes; Molecular Structure; Pyrrolidines; Stereoisomerism; Zinc Compounds

2014