vernakalant has been researched along with zinc-chloride* in 1 studies
1 other study(ies) available for vernakalant and zinc-chloride
Article | Year |
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A highly efficient asymmetric synthesis of vernakalant.
A novel synthesis of vernakalant is described. Using inexpensive and readily available reagents, the key transformations involve (1) an efficient zinc-amine-promoted etherification, (2) a highly stereoselective enzyme-catalyzed dynamic asymmetric transamination to set up the two contiguous chiral centers in the cyclohexane ring, and (3) a pyrrolidine ring formation via alkyl-B(OH)2-catalyzed amidation and subsequent imide reduction. Topics: Amination; Amines; Anisoles; Catalysis; Chlorides; Cyclohexanes; Molecular Structure; Pyrrolidines; Stereoisomerism; Zinc Compounds | 2014 |