veratrine has been researched along with stearic-acid* in 2 studies
2 other study(ies) available for veratrine and stearic-acid
| Article | Year |
|---|---|
Interactions of veratrum alkaloids, procaine, and calcium with monolayers of stearic acid and their implications for pharmacological action.
The interactions of veratridine, cevadine, veracevine, and veratramine with monolayers of stearic acid show marked differences. Veratridine and cevadine, at concentrations that are known from potential, ionic flux, and other measurements to affect living membranes, react strongly with the film and appear to cause an "interfacial dissolution" whereby both the alkaloid and the stearate leave the surface. Veracevine at the same concentration does not interact with the film. The veratramine reaction is weak, much like that of the local anesthetic procaine. The veratridine and cevadine effects are antagonized by 10(-3)M Ca(++), low pH, and 3.7 and 7.4 x 10(-3)M procaine. These differences among the veratrum alkaloids and the antagonisms parallel effects observed in living systems. Such parallelism suggests that similar physical interactions are involved in the stearate film and in natural membranes. Topics: Anesthetics, Local; Calcium; Procaine; Stearates; Stearic Acids; Veratrine; Veratrum; Veratrum Alkaloids | 1960 |
Antagonism of veratrine by calcium ion in monolayers of stearic acid.
Force-area diagrams for monolayers of stearic acid on Ringer's solution demonstrate a competition between veratrine and calcium for carboxyl groups of the films. The competition occurs at customary concentrations. Local anesthetics act quite differently. The interactions suggest those observed less directly in living cells and therefore indicate that such surface films may serve as models for the study of drug and ion effects. Topics: Calcium; Ions; Isotonic Solutions; Ringer's Solution; Stearic Acids; Veratrine; Veratrum Alkaloids | 1959 |