veratrine and 4-desmethoxyverapamil

veratrine has been researched along with 4-desmethoxyverapamil* in 1 studies

Other Studies

1 other study(ies) available for veratrine and 4-desmethoxyverapamil

ArticleYear
Participation of intracellular sites in the action of Ca2+ channel blockers.
    European journal of pharmacology, 1986, Nov-04, Volume: 130, Issue:3

    The action of phenylalkylamine Ca2+ channel blockers D890 and D888 on Ca2+ uptake and neurotransmitter amino acid release were studied. D890, the quaternary derivative of D600, did not inhibit veratrine-induced 45Ca2+ uptake or the release of neurotransmitter amino acids from rat cerebrocortical synaptosomes, except at high concentrations (200 microM) when it was probably acting extracellularly in a non-specific manner. This contrasted with the more potent (10-50 microM) inhibitory actions of D600 and D888, and may be due to the inability of D890 to cross the synaptic plasma membrane. (-)D888 was shown to cross cell membranes and accumulate in the intracellular compartment of cerebrocortical slices and synaptosomes, where it was associated predominantly with the soluble cytoplasmic fraction.

    Topics: Amino Acids; Animals; Calcium Channel Blockers; Calcium Radioisotopes; Cerebral Cortex; Gallopamil; In Vitro Techniques; Potassium; Rats; Synaptosomes; Verapamil; Veratrine

1986