verapamil has been researched along with theophylline in 196 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 89 (45.41) | 18.7374 |
| 1990's | 30 (15.31) | 18.2507 |
| 2000's | 26 (13.27) | 29.6817 |
| 2010's | 48 (24.49) | 24.3611 |
| 2020's | 3 (1.53) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Gubernator, K; Kansy, M; Senner, F | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Caron, G; Ermondi, G | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Alfieri, A; Crescenzi, B; Gardelli, C; Muraglia, E; Nizi, E; Orsale, MV; Pescatore, G; Spieser, SA; Summa, V | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Akamatsu, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, J; Chen, X; Huang, L; Li, X; Sun, Y | 1 |
| Huang, L; Li, X; Meng, F; Miao, H; Sun, Y | 1 |
| Deng, Y; Li, Y; Liu, Q; Qiang, X; Sang, Z; Tan, Z; Xiao, G | 1 |
| Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bai, P; Chen, C; Hu, K; Li, T; Liu, W; Ma, Q; Pan, W; Peng, K; Sang, Z; Yu, L; Zhang, X | 1 |
| Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xiao, G | 1 |
| Bienkowski, P; Bucki, A; Gobec, S; Godyń, J; Głuch-Lutwin, M; Kazek, G; Knez, D; Kołaczkowski, M; Malawska, B; Marcinkowska, M; Mierzejewski, P; Sienkiewicz-Jarosz, H; Siwek, A; Wichur, T; Więckowska, A; Więckowski, K; Zaręba, P | 1 |
| Brazzolotto, X; Brus, B; Colletier, JP; Coquelle, N; Gobec, S; Knez, D; Kos, J; Košak, U; Nachon, F; Pišlar, A | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Yang, X; Zheng, Y | 1 |
| Ai, J; Deng, Y; Li, Y; Liu, Q; Luo, L; Qiang, X; Tan, Z; Xiao, G; Yang, X | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Sang, Z; Su, F; Xiao, G; Xu, R; Yang, X; Zheng, Y | 1 |
| Antonov, L; Gastreich, M; Hristova, S; Neumann, B; Stammler, HG; Tzvetkov, NT | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Tan, Z; Xu, R; Yang, X; Zheng, Y | 1 |
| Cao, Z; Deng, Y; Li, Y; Luo, L; Qiang, X; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, X | 1 |
| Guo, QL; Huang, SL; Huang, ZS; Li, D; Liu, ZQ; Ou, TM; Tan, JH; Wang, HG; Wang, N; Wu, JQ; Xia, CL | 1 |
| Bai, P; Leng, C; Li, X; Liu, W; Ma, Q; Pan, W; Sang, Z; Tan, Z; Wang, K; Xu, Q; Yang, Y; Yu, L | 1 |
| Liu, W; Ma, Q; Pan, W; Sang, Z; Wang, K; Yu, L | 1 |
| Hao, L; Huang, W; Jin, H; Liang, L; Niu, Y; Wang, C; Wang, W; Xu, F; Xu, P; Yan, G | 1 |
| Han, X; Liu, W; Ma, Q; Sang, Z; Wang, H; Wang, K; Ye, M; Yu, L | 2 |
| Chreifi, G; Do, HT; Li, H; Poulos, TL; Silverman, RB; Wang, HY | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Xu, R; Yang, J; Zhang, X | 1 |
| Deng, Y; Li, Y; Liu, H; Song, Q; Tan, Z; Xiao, G; Xu, R; Yang, Z; Zhang, X; Zheng, Y | 1 |
| An, Q; Deng, Y; Liu, P; Luo, Y; Sang, Z; Tang, Y; Wang, T; Yang, T; Yang, Y; Zhang, T | 1 |
| Cao, Z; Deng, Y; Li, Y; Liu, H; Qiang, X; Song, Q; Tan, Z; Tian, C; Yang, Z | 1 |
| Antonov, L; Atanasov, AG; Hristova, S; Stammler, HG; Tzvetkov, NT | 1 |
| An, B; Hu, J; Huang, L; Li, X; Li, Z; Pan, T | 1 |
| Deng, Y; He, Y; Li, W; Liu, H; Qiang, X; Song, Q; Tan, Z; Ye, C | 1 |
| Hayashi, T; Murata, M; Tsuchikawa, H; Umegawa, Y | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K | 1 |
| Liu, W; Sang, Z; Shi, J; Tan, Z; Wang, K; Zhang, P | 1 |
| Fan, X; Liu, W; Sang, Z; Shi, J; Wang, K; Yang, D; Zhang, P; Zhang, Z; Zhu, G | 1 |
| Bai, P; Cheng, X; Cheng, Y; Lu, X; Sang, Z; Shi, J; Wang, K; Yang, J; Zhang, P; Zhang, Q; Zheng, C | 1 |
| Barlow, D; Ciarlo, L; Dimmito, MP; Houseknecht, KL; Lei, W; Macedonio, G; Mollica, A; Novellino, E; Pieretti, S; Stefanucci, A; Streicher, JM | 1 |
| Calzaferri, F; de Diego, AMG; de Los Ríos, C; de Pascual, R; Egea, J; García, AG; Narros-Fernández, P; Nicke, A | 1 |
| Hardy, CD; Li, H; Poulos, TL; Silverman, RB; Vasu, D | 1 |
| Duncan, CJ; Publicover, SJ | 1 |
| Besch, HR; Watanabe, AM | 1 |
| Dretchen, KL; Morgenroth, VH; Skirboll, LR; Standaert, FG | 1 |
| Toda, N | 1 |
| Dretchen, KL; Raines, A; Standaert, FG | 1 |
| Oshima, K; Takenaka, A | 1 |
| Kaji, E; Murakami, H; Segawa, T | 1 |
| Needham, GR; Sauer, JR | 1 |
| Crocker, AD; Mayeka, IM; Wilson, KA | 1 |
| Herchuelz, A; Levy, J; Malaisse, WJ; Sener, A | 1 |
| Cohen, J; Gutman, Y | 1 |
| Daniel, EE; Fox, JA | 1 |
| Dominguez, ML; Gonçalves, MJ; Ribeiro, JA | 1 |
| Devis, G; Malaisse, WJ; Pipeleers, DG; Somers, G | 1 |
| Devis, G; Malaisse, WJ; Somers, G; Van Obberghen, E | 2 |
| Devis, G; Malaisse, WJ; Somers, G | 1 |
| Ohkawa, H; Watanabe, M | 1 |
| Hoffmann, A; Siegers, CP; Sierra-Callejas, JL; Strubelt, O | 1 |
| Lampe, D; Mai, I | 1 |
| Bennett, MR; Kerr, R; Khurana, G | 1 |
| Clarke, M; Lindenfeld, JA; Mallet, J; Stringer, KA | 1 |
| Fuhr, U; Siewert, M; Woodcock, BG | 1 |
| Mellemkjaer, S; Nielsen, CB; Nielsen-Kudsk, JE | 1 |
| Kolbeck, RC; Speir, WA | 2 |
| Harmeyer, J; Kaune, R; Schröder, B | 1 |
| Cirillo, R; Franzone, JS; Reboani, MC | 1 |
| Abe, S; Hirano, Y; Hiraoka, M; Sawanobori, T | 1 |
| Bittar, G; Dominguez, A; Friedman, HS; Vorperian, V | 1 |
| Bang, L; Brønsgaard, AM; Nielsen-Kudsk, JE | 1 |
| Nikitina, EI | 1 |
| Abedin, MZ; Cates, JA; Kleinman, R; Roslyn, JJ; Saunders, KD | 1 |
| Baumelou, A; Baumelou, B; Cacoub, P; Deray, G; Jacobs, C; Martinez, F | 1 |
| Bolufer, J; Calonge, ML; Ilundáin, A; Montero, MC | 1 |
| Buhl, JS; Johannessen, AC; Nielsen-Kudsk, JE | 1 |
| Hanson, RL; Isaacson, CM | 1 |
| Forsyth, GW; Maenz, DD; Wong, PH | 1 |
| Advenier, C; Lockhart, A; Matran, R; Naline, E; Regoli, D; Tricot, JF | 1 |
| Dasarathy, Y; Fanburg, BL | 1 |
| Brand, A; Heidland, A; Röckel, A; Zenglein, H | 1 |
| Furuki, Y; Hatada, Y; Maeyama, M; Miyamoto, E; Munemura, M; Sakoda, Y | 1 |
| Rindone, JP; Sock, JA; Zuniga, R | 1 |
| Nielsen-Kudsk, JE | 1 |
| Gin, AS; Matthews, GE; Stringer, KA; Welage, LS; Wilton, JH | 1 |
| Abadir, AR; Gintautas, J; Longmore, W; Mitra, P; Pillalamarri, ED | 1 |
| Ohe, T; Shimorura, K; Taniguchi, A | 1 |
| Boschetto, P; Crescioli, S; dal Vecchio, L; de Marzo, N; Fabbri, LM; Mapp, C; Paleari, D | 1 |
| Baciewicz, AM; Bekemeyer, WB; Self, TH | 1 |
| Knodell, RG; Steele, NM | 1 |
| Chadwick, A; Hall, TR; Harvey, S | 1 |
| Cheng, H; Cohen, P; Donowitz, M; Elta, G; Levin, S; Powers, G | 1 |
| Benigni, A; de Gaetano, G; Dodesini, P; Livio, M; Mecca, G; Panigada, M; Remuzzi, G; Schieppati, A | 1 |
| Barnes, PJ; Cuss, FM; Grandordy, BM | 1 |
| Malmgren, R | 1 |
| Esau, SA | 2 |
| Abernethy, DR; Carrum, G; Dickinson, TH; Egan, JM | 1 |
| Birkett, DJ; Matthews, AP; McManus, ME; Meller, D; Miners, JO; Robson, RA; Stupans, I | 1 |
| Birkett, DJ; Miners, JO; Robson, RA | 1 |
| Aviles, AI; Johnson, CE; Lloyd, CW; Rybarz, KL | 1 |
| Lalonde, RL; Pieper, JA; Self, TH; Sirmans, SM; Smith, DG | 1 |
| Ilundain, A; Larralde, J; Toval, M | 1 |
| Karlsson, JA; Nielsen-Kudsk, JE; Persson, CG | 1 |
| Malaisse, WJ; Mathias, PC | 1 |
| Biancani, P; Hong, KW; Weiss, RM | 1 |
| Kimura, T; Satoh, S | 1 |
| Alcalde, AI; Barcina, Y; Ilundain, A; Larralde, J | 1 |
| Calixto, JB; Loch, S | 1 |
| Marchlinski, FE; Miller, JM | 1 |
| Meisel, M; Meisel, P | 1 |
| Junge-Hülsing, G; Schmitt, G; Wagner, H | 1 |
| Byon, KY; Fleckenstein, A | 1 |
| Eto, S; Fleischer, N; Hutchins, M; Wood, JM | 1 |
| Gokel, M; Haas, H | 1 |
| Duchêne-Marullaz, P; Lavarenne, J | 1 |
| Kolassa, N; Pfleger, K; Volkmer, I | 1 |
| Both, A | 1 |
| Carlson, HE | 1 |
| Hardcastle, J; Hardcastle, PT; Noble, JM | 1 |
| Charles, S; Henquin, JC; Mathot, F; Nenquin, M; Tamagawa, T | 1 |
| Malaisse, WJ | 1 |
| Hubel, KA | 1 |
| Gagnon, G; Regoli, D; Rioux, F | 1 |
| Kurose, M | 1 |
| Barbero, L; Markowicz, J; Weiss, EB | 1 |
| Hirai, M; Komoriyama, K; Kouyama, H; Shima, S | 1 |
| Kopf, GS; Lewis, CA; Vacquier, VD | 1 |
| Asarkof, N; Donowitz, M; Pike, G | 1 |
| Brenner, BM; Humes, HD; Simmons, CF | 1 |
| Markosian, RA; Suvorov, AV | 1 |
| Müller, A; Rabe, T; Runnebaum, B; Scheurer, A | 1 |
| Shuttleworth, TJ | 1 |
| Goldenberg, MM; Meurer, RD | 1 |
| Couper, GS; Hiltbrand, B; Shine, KI; Weiss, J | 1 |
| Greenberg, A; Kroboth, PD; Piraino, BH; Weiss, J | 1 |
| Andriani, A; Chiappetta, MG; Fabiani, M | 1 |
| Pento, JT | 1 |
| Lessem, J | 1 |
| Brady, RC; Hilfer, SR | 1 |
| Gutman, Y; Koren, R; Zilberman, Y | 1 |
| Asarkof, N; Donowitz, M | 1 |
| Chuck, LH; Parmley, WW | 1 |
| Mellemkjaer, S; Nielsen-Kudsk, JE; Thirstrup, S | 1 |
| Borre, A; Hoffman, DJ; Nellans, HN; Seifert, T | 1 |
| Cortijo, J; Morcillo, EJ; Orón, JD; Perpiñá, M | 1 |
| Cortijo, J; Morcillo, EJ; Sanz, CM; Small, RC; Villagrasa, V | 1 |
| Ashraf, G; Javed, MH; Saeed, SA | 1 |
| Homma, S; Kuramochi, G | 1 |
| Wijnand, HP | 1 |
| Alcorn, D; Berka, JL; Ryan, GB; Skinner, SL; Weaver, DA | 1 |
| Barcones Mingueza, F; Capitan Guarnizo, R; Ibarra de la Rosa, I; Pérez Navero, JL; Ulloa Santamaría, E; Velasco Jabalquinto, MJ | 1 |
| Aungst, BJ; Saitoh, H | 1 |
| Decramer, M; Gayan-Ramirez, G; Himpens, B; Janssens, S | 1 |
| Alleva, FR; Balazs, T; Joseph, X; Vick, JA; Whitehurst, VE; Zhang, J | 1 |
| Hyson, DH; Kappagoda, CT; Keelan, M; Thomson, AB | 1 |
| Kildalsen, H; Sager, G; Schultz, C; Vaskinn, S | 1 |
| Broeders, ME; Folgering, HT; Heijdra, YF; Kramers, C; Smits, P | 1 |
| Kivistö, KT; Lapatto-Reiniluoto, O; Neuvonen, PJ | 1 |
| Erdmann, H; Gebert, S; Kolter, K; Schepky, G | 1 |
| Küçukhüseyin, C; Oncel, H; Silan, C | 1 |
| Bodmeier, R; Pearnchob, N; Siepmann, J | 1 |
| Faulkner, MA; Lenz, NJ; Lenz, TL | 1 |
| Bai, SA; Christ, DD; Diamond, S; Grace, JE; Grossman, SJ; He, K; Qian, M; Wong, H; Wright, MR; Yeleswaram, K | 1 |
| Bärtsch, P; Burhenne, J; Dehnert, C; Göggelmann, C; Haefeli, WE; Menold, E; Mikus, G; Riedel, KD; Streit, M | 1 |
| Onur, R; Yenisehirli, A | 1 |
| Juvekar, AR; Shah, KJ | 1 |
| Carpentier, YA; Chardigny, JM; Herchuelz, A; Louchami, K; Malaisse, WJ; Oguzhan, B; Portois, L; Sener, A; Zhang, Y | 1 |
| Ames, CD; Bhayani, S; Dryer, ST; Figenshau, RS; Hruby, G; Landman, J; Minor, SD; Venkatesh, R; Weld, KJ; Yan, Y | 1 |
| Batzias, GC; Koutsoviti-Papadopoulou, M; Psarra, TA | 1 |
| Farrell, TP; Huatan, H; Missaghi, S; Patel, P; Rajabi-Siahboomi, AR | 1 |
| Mendyk, E; Smolarz, HD; Załuski, D | 1 |
| Reinen, J; Smit, M; Wenker, M | 1 |
6 review(s) available for verapamil and theophylline
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Is adenosine the mediator for the regulation of the coronary circulation and for the effect of coronarodilators? Review].
Topics: Adenosine; Adenosine Triphosphate; Aminohydrolases; Aminophylline; Animals; Calcium; Carbon Dioxide; Coronary Circulation; Coronary Vessels; Dipyridamole; Dogs; Hydrogen-Ion Concentration; Hypoxanthines; Hypoxia; Inosine; Nitroglycerin; Oxidative Phosphorylation; Oxygen Consumption; Papaverine; Partial Pressure; Prenylamine; Theophylline; Vasodilator Agents; Verapamil | 1974 |
[Recent data on coronary dilators].
Topics: Amino Alcohols; Aminophylline; Animals; Benzofurans; Cardiovascular Diseases; Cats; Coronary Disease; Dipyridamole; Dogs; Humans; Monoamine Oxidase Inhibitors; Nitrites; Papaverine; Prenylamine; Rabbits; Rats; Sympatholytics; Theophylline; Vasodilator Agents; Verapamil | 1968 |
Role of calcium in the regulation of hormonal secretion.
Topics: Acyltransferases; Animals; Ca(2+) Mg(2+)-ATPase; Calcimycin; Calcium; Calcium-Transporting ATPases; Calmodulin; Cytoskeleton; Dose-Response Relationship, Drug; Glucose; Insulin; Insulin Secretion; Intracellular Fluid; Islets of Langerhans; Potassium; Theophylline; Transglutaminases; Verapamil; Vincristine | 1984 |
[Platelet aggregation and antiaggregant drugs].
Topics: Dipyridamole; Humans; Papaverine; Platelet Aggregation; Prostaglandins; Theophylline; Thiophenes; Thromboxane A2; Ticlopidine; Verapamil | 1982 |
Potential interactions between exercise and drug therapy.
Topics: Absorption; Acetaminophen; Adrenergic beta-Antagonists; Aspirin; Digoxin; Doxycycline; Exercise; Humans; Insulin; Pharmacokinetics; Theophylline; Tissue Distribution; Verapamil; Warfarin | 2004 |
9 trial(s) available for verapamil and theophylline
| Article | Year |
|---|---|
The effect of three different oral doses of verapamil on the disposition of theophylline.
Topics: Administration, Oral; Adult; Blood Pressure; Drug Interactions; Heart Rate; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Theophylline; Verapamil | 1992 |
The effect of verapamil on the pharmacokinetic disposition of theophylline in cigarette smokers.
Topics: Adult; Blood Pressure; Drug Interactions; Electrocardiography; Heart Rate; Humans; Male; Smoking; Spectrometry, Fluorescence; Theophylline; Verapamil | 1989 |
Protective effect of antiasthma drugs on late asthmatic reactions and increased airway responsiveness induced by toluene diisocyanate in sensitized subjects.
Topics: Asthma; Beclomethasone; Bronchial Provocation Tests; Clinical Trials as Topic; Cromolyn Sodium; Cyanates; Delayed-Action Preparations; Double-Blind Method; Forced Expiratory Volume; Humans; Immunization; Lung; Methacholine Chloride; Methacholine Compounds; Placebos; Random Allocation; Respiratory System; Theophylline; Time Factors; Toluene 2,4-Diisocyanate; Verapamil | 1987 |
Selective inhibitory effects of nifedipine and verapamil on oxidative metabolism: effects on theophylline.
Topics: Adolescent; Adult; Humans; Male; Nifedipine; Oxidation-Reduction; Theophylline; Verapamil | 1988 |
Effect of calcium channel blockers on theophylline disposition.
Topics: Adult; Calcium Channel Blockers; Data Interpretation, Statistical; Diltiazem; Half-Life; Humans; Male; Nifedipine; Random Allocation; Theophylline; Verapamil | 1988 |
Radionuclide evaluation of CHF.
Topics: Adolescent; Adult; Coronary Disease; Digoxin; Female; Heart Aneurysm; Heart Failure; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Nitroglycerin; Propranolol; Radionuclide Imaging; Technetium; Theophylline; Verapamil | 1981 |
Verapamil causes decreased diaphragm endurance but no decrease of nocturnal O(2) saturation in patients with chronic obstructive pulmonary disease.
Topics: Aged; Blood Gas Analysis; Calcium Channel Blockers; Circadian Rhythm; Cross-Over Studies; Diaphragm; Double-Blind Method; Drug Interactions; Humans; Lung Diseases, Obstructive; Middle Aged; Muscle Contraction; Muscle, Skeletal; Oxygen; Placebos; Theophylline; Vasodilator Agents; Verapamil | 2000 |
Activated charcoal alone and followed by whole-bowel irrigation in preventing the absorption of sustained-release drugs.
Topics: Adult; Anticonvulsants; Antidotes; Area Under Curve; Bronchodilator Agents; Calcium Channel Blockers; Carbamazepine; Charcoal; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Intestinal Absorption; Male; Theophylline; Therapeutic Irrigation; Verapamil | 2001 |
Cytochrome P450 enzyme-mediated drug metabolism at exposure to acute hypoxia (corresponding to an altitude of 4,500 m).
Topics: Adult; Altitude; Area Under Curve; Calcium Channel Blockers; Cross-Over Studies; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Half-Life; Humans; Hypoxia; Infusions, Intravenous; Liver Circulation; Male; Theophylline; Vasodilator Agents; Verapamil | 2005 |
181 other study(ies) available for verapamil and theophylline
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.
Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Dihydroxy-pyrimidine and N-methylpyrimidone HIV-integrase inhibitors: improving cell based activity by the quaternarization of a chiral center.
Topics: Animals; Cell Membrane Permeability; HIV Integrase; HIV Integrase Inhibitors; Humans; Protein Binding; Pyrimidines; Pyrimidinones; Rats | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids.
Topics: Alzheimer Disease; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Cholinesterases; Electrophorus; Humans; Isoflavones; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Swine; Tacrine | 2013 |
Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Humans; Indans; Inhibitory Concentration 50; Ligands; Peptide Fragments; Permeability; Protein Aggregates | 2014 |
Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Apigenin; Blood-Brain Barrier; Butyrylcholinesterase; Carbamates; Cell Line; Chelating Agents; Cholinesterase Inhibitors; Cognition; Glucuronates; Humans; Mice; Molecular Docking Simulation; Neuroprotective Agents; Rats | 2015 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Humans; Indans; Indoles; Male; Memory; Mice; Models, Molecular; Neuroprotective Agents; Phthalimides; Piperidines; Protein Aggregates; Scopolamine; Structure-Activity Relationship | 2015 |
Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alkanes; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Drug Evaluation, Preclinical; Ethylamines; Humans; Hydrogen Peroxide; Neuroprotective Agents; PC12 Cells; Rats | 2016 |
Synthesis and evaluation of 4-hydroxyl aurone derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Benzofurans; Blood-Brain Barrier; Chelating Agents; Copper; Humans; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Swine | 2016 |
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Ligands; Male; Models, Molecular; Molecular Targeted Therapy; Protein Conformation; Rats; Rats, Wistar; Receptors, Serotonin | 2016 |
N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Death; Cell Line; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Naphthalenes; Peptide Fragments; Piperidines; Structure-Activity Relationship; Sulfonamides | 2017 |
Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Isoflavones; Mannich Bases; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2017 |
Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Mannich Bases; Neuroprotective Agents; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Rivastigmine; Structure-Activity Relationship; Swine | 2017 |
Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors.
Topics: Animals; Blood-Brain Barrier; Brain; Crystallography, X-Ray; Gastrointestinal Tract; Humans; Indazoles; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Binding; Protein Conformation; Rats; Solubility; Species Specificity; Structure-Activity Relationship; Water | 2017 |
DL-3-n-butylphthalide-Edaravone hybrids as novel dual inhibitors of amyloid-β aggregation and monoamine oxidases with high antioxidant potency for Alzheimer's therapy.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Antipyrine; Benzofurans; Binding Sites; Blood-Brain Barrier; Edaravone; Humans; Hydrogen Bonding; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Protein Binding; Protein Structure, Tertiary | 2017 |
Multifunctional thioxanthone derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line; Cholinesterase Inhibitors; Humans; Kinetics; Models, Molecular; Monoamine Oxidase Inhibitors; Thioxanthenes; Xanthones | 2017 |
Design, synthesis and evaluation of 2-arylethenyl-N-methylquinolinium derivatives as effective multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Death; Cell Line; Cholinesterase Inhibitors; Drug Design; Glutathione; Humans; Quinolines; Reactive Oxygen Species | 2017 |
Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Drug Design; Eels; Humans; Memory Disorders; Mice; PC12 Cells; Rats | 2017 |
Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Drug Design; Electrophorus; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quinolines; Swine | 2017 |
2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies.
Topics: Acetamides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; HEK293 Cells; Humans; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amines; Binding Sites; Blood-Brain Barrier; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Cholinesterases; Drug Design; Humans; Inhibitory Concentration 50; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phthalimides; Protein Structure, Tertiary; Structure-Activity Relationship | 2017 |
Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Antioxidants; Benzophenones; Binding Sites; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Drug Design; Humans; Hydrogen Peroxide; Inhibitory Concentration 50; Molecular Docking Simulation; Monoamine Oxidase; Neuroprotective Agents; PC12 Cells; Permeability; Phenols; Piperazines; Protein Structure, Tertiary; Rats; Structure-Activity Relationship | 2017 |
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Topics: Aminopyridines; Animals; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Crystallography, X-Ray; Fluorobenzenes; Humans; Mice; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Structure-Activity Relationship; Swine; Theophylline; Verapamil | 2017 |
Design, synthesis and evaluation of 4'-OH-flurbiprofen-chalcone hybrids as potential multifunctional agents for Alzheimer's disease treatment.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Cell Line; Cell Survival; Chalcones; Chelating Agents; Copper; Drug Design; Flurbiprofen; Humans; Lipopolysaccharides; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nitric Oxide; Peptide Fragments; Recombinant Proteins; Structure-Activity Relationship | 2018 |
Multifunctional 5,6-dimethoxybenzo[d]isothiazol-3(2H)-one-N-alkylbenzylamine derivatives with acetylcholinesterase, monoamine oxidases and β-amyloid aggregation inhibitory activities as potential agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Benzylamines; Blood-Brain Barrier; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Aggregates; Recombinant Proteins; Structure-Activity Relationship; Thiazoles | 2018 |
Discovery of novel anti-tuberculosis agents with pyrrolo[1,2-a]quinoxaline-based scaffold.
Topics: Antineoplastic Agents; Antitubercular Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Pyrroles; Quinoxalines; Structure-Activity Relationship | 2018 |
Discovery of novel 2,5-dihydroxyterephthalamide derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Butyrylcholinesterase; Chelating Agents; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Peptide Fragments; Phthalimides; Protein Aggregates; Structure-Activity Relationship | 2018 |
(Pyrrolo-pyridin-5-yl)benzamides: BBB permeable monoamine oxidase B inhibitors with neuroprotective effect on cortical neurons.
Topics: Benzamides; Blood-Brain Barrier; Cerebral Cortex; Models, Neurological; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurons; Neuroprotective Agents; Permeability; Structure-Activity Relationship | 2019 |
Synthesis and evaluation of clioquinol-rolipram/roflumilast hybrids as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Aminopyridines; Animals; Benzamides; Clioquinol; Cyclic Nucleotide Phosphodiesterases, Type 4; Cyclopropanes; Drug Design; Humans; Ligands; Mice; Rats; Rolipram | 2019 |
Discovery of 4'-OH-flurbiprofen Mannich base derivatives as potential Alzheimer's disease treatment with multiple inhibitory activities.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Drug Design; Drug Discovery; Electrophorus; Flurbiprofen; Humans; Mannich Bases; Molecular Docking Simulation; Peptide Fragments; Protein Aggregates; Rats; Swine | 2019 |
Small structural alterations greatly influence the membrane affinity of lipophilic ligands: Membrane interactions of bafilomycin A
Topics: Cell Membrane; Cell Membrane Permeability; Fluorine; Hydrogen Bonding; Kinetics; Ligands; Macrolides; Magnetic Resonance Spectroscopy | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Eels; Female; Horses; Humans; Male; Maze Learning; Mice; Mice, Inbred Strains; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Protein Aggregates; Rats; Structure-Activity Relationship | 2019 |
Design, synthesis, in-silico and biological evaluation of novel chalcone derivatives as multi-function agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Butyrylcholinesterase; Chalcone; Cholinesterase Inhibitors; Drug Design; Eels; Horses; Humans; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Peptide Fragments; Protein Aggregates | 2019 |
The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Drug Development; Humans; Kinetics; Models, Molecular; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Structure-Activity Relationship | 2019 |
Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Biological Transport; Blood-Brain Barrier; Butyrylcholinesterase; Chalcones; Chelating Agents; Cholinesterase Inhibitors; Coordination Complexes; Copper; Drug Design; Female; Humans; Male; Memory Disorders; Mice; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Protein Binding; Scopolamine; Structure-Activity Relationship | 2019 |
Potent, Efficacious, and Stable Cyclic Opioid Peptides with Long Lasting Antinociceptive Effect after Peripheral Administration.
Topics: Administration, Intravenous; Analgesics, Opioid; Animals; CHO Cells; Cricetulus; Female; Humans; Infusions, Subcutaneous; Male; Mice; Models, Molecular; Opioid Peptides; Pain; Peptides, Cyclic; Receptors, Opioid | 2020 |
Synthesis and Pharmacological Evaluation of Novel Non-nucleotide Purine Derivatives as P2X7 Antagonists for the Treatment of Neuroinflammation.
Topics: Adenosine Triphosphatases; Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; HEK293 Cells; Humans; Interleukin-1beta; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Molecular Docking Simulation; Oocytes; Purinergic P2X Receptor Antagonists; Purines; Receptors, Purinergic P2X7; Xenopus laevis | 2021 |
2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors.
Topics: Aminopyridines; Animals; Enzyme Inhibitors; Humans; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Protein Isoforms; Rats | 2022 |
The action of verapamil on the rate of spontaneous release of transmitter at the frog neuromuscular junction.
Topics: Action Potentials; Animals; Anura; Calcium; Dantrolene; Female; Gallopamil; In Vitro Techniques; Male; Motor Endplate; Neuromuscular Junction; Neurotransmitter Agents; Rana pipiens; Temperature; Theophylline; Verapamil | 1979 |
The relationship between adenosine 3',5'-monophosphate levels and systolic transmembrane calcium flux.
Topics: Animals; Biological Transport; Calcium; Cyclic AMP; Dose-Response Relationship, Drug; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Myocardium; Ouabain; Papaverine; Potassium; Propranolol; Theophylline; Verapamil | 1975 |
A role of cyclic nucleotides in neuromuscular transmission.
Topics: Adenosine; Alloxan; Animals; Axons; Bucladesine; Cats; Cyclic AMP; Dithionitrobenzoic Acid; Electric Stimulation; Fluorides; Gallopamil; Imidazoles; Muscle Contraction; Muscle Denervation; Muscles; Nerve Endings; Neuromuscular Junction; Prostaglandins E; Synaptic Transmission; Theophylline; Verapamil | 1976 |
Participation of calcium and sodium ions in genesis of the chronotropic effect of norepinephrine in isolated rabbit sinoatrial nodes.
Topics: Animals; Bucladesine; Calcium; Dose-Response Relationship, Drug; Female; Heart Rate; In Vitro Techniques; Ions; Male; Manganese; Membrane Potentials; Norepinephrine; Rabbits; Sinoatrial Node; Sodium; Stimulation, Chemical; Theophylline; Verapamil | 1977 |
Effects of phenytoin on the cyclic nucleotide system in the motor nerve terminal.
Topics: Animals; Bucladesine; Calcium Chloride; Cats; Electric Stimulation; Evoked Potentials; Hindlimb; Motor Neurons; Muscle Contraction; Neuromuscular Junction; Nucleotides, Cyclic; Phenytoin; Pyridines; Sodium Fluoride; Tetany; Tetraethylammonium Compounds; Theophylline; Verapamil | 1977 |
Electrophysiological effects effects of prostaglandin F 2 alpha and E1 on the oviduct of the pregnant guinea pig in relation to Ca++.
Topics: Action Potentials; Animals; Bucladesine; Calcium; Cations, Divalent; Fallopian Tubes; Female; Guinea Pigs; Muscle Contraction; Ovum Transport; Pregnancy; Prostaglandins E; Prostaglandins F; Theophylline; Verapamil | 1978 |
Influences of verapamil, X-537A, A-23187 and adenosine 3',5'-cyclic monophosphate on release of 5-hydroxytryptamine from rat brain slices.
Topics: Animals; Anti-Bacterial Agents; Brain; Calcimycin; Calcium; Cyclic AMP; In Vitro Techniques; Lasalocid; Male; Potassium; Rats; Serotonin; Theophylline; Verapamil | 1978 |
Involvement of calcium and cyclic AMP in controlling ixodid tick salivary fluid secretion.
Topics: Animals; Blood; Calcimycin; Calcium; Cyclic AMP; Dopamine; Drug Antagonism; Feeding Behavior; Female; In Vitro Techniques; Salivary Glands; Salivation; Theophylline; Ticks; Verapamil | 1979 |
The role of calcium and cyclic AMP in the contractile action of angiotensin II upon rat descending colon.
Topics: Angiotensin II; Animals; Bucladesine; Calcium; Colon; Cyclic AMP; Imidazoles; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle, Smooth; Proadifen; Rats; Theophylline; Time Factors; Verapamil | 1979 |
Calcium antagonists and islet function--III. The possible site of action of verapamil.
Topics: Animals; Calcium; Female; Glucose; Insulin; Islets of Langerhans; Lactates; Phentolamine; Proinsulin; Rats; Theophylline; Verapamil | 1977 |
Effects of verapamil, dantrolene and lanthanum on catecholamine release from rat adrenal medulla.
Topics: Adrenal Medulla; Animals; Catecholamines; Dantrolene; Hydantoins; In Vitro Techniques; Lanthanum; Male; Potassium Chloride; Rats; Theophylline; Tyramine; Verapamil | 1979 |
Role of Ca2+ in genesis of lower esophageal sphincter tone and other active contractions.
Topics: Animals; Calcium; Esophagogastric Junction; Ethanol; Female; Lanthanum; Male; Muscle Contraction; Muscle Tonus; Muscle, Smooth; Nifedipine; Nitroprusside; Opossums; Theophylline; Verapamil | 1979 |
Purine effects at the neuromuscular junction and their modification by theophylline, imidazole and verapamil.
Topics: Adenosine; Adenosine Triphosphate; Animals; Drug Interactions; Female; Imidazoles; In Vitro Techniques; Male; Muscle Contraction; Neuromuscular Junction; Norepinephrine; Ouabain; Purine Nucleosides; Purine Nucleotides; Rats; Theophylline; Verapamil | 1979 |
Calcium-antagonists and islet function. IV. Effect of D600.
Topics: Animals; Biological Transport; Calcium; Gallopamil; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Theophylline; Verapamil | 1976 |
Calcium antagonists and islet function. II. Interaction of theophylline and verapamil.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Pancreas; Perfusion; Rats; Stimulation, Chemical; Theophylline; Verapamil | 1976 |
Stimulation of insulin release by calcium.
Topics: Animals; Calcium; Egtazic Acid; In Vitro Techniques; Insulin; Insulin Secretion; Pancreas; Perfusion; Rats; Theophylline; Verapamil | 1975 |
Calcium-antagonists and islet function. VI. Effects of barium.
Topics: Animals; Barium; Biological Transport, Active; Calcium; Cytochalasin B; Egtazic Acid; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Theophylline; Verapamil | 1976 |
Effects of gastrointestinal hormones on the electrical and mechanical activity of the cat stomach.
Topics: Action Potentials; Animals; Atropine; Caffeine; Cats; Cholecystokinin; Gastrins; Gastrointestinal Hormones; Imidazoles; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Pyloric Antrum; Secretin; Stomach; Tetrodotoxin; Theophylline; Verapamil | 1977 |
On the pathogenesis of cardiac necroses induced by theophylline and caffeine.
Topics: Animals; Blood Pressure; Caffeine; Calcium; Gallopamil; Heart; Heart Rate; Isoproterenol; Male; Myocarditis; Myocardium; Necrosis; Oxygen Consumption; Propranolol; Rats; Theophylline; Verapamil | 1976 |
[Influence of spasmolytic agents on the cumulative calcium dose-effect curve in isolation-perfused peripheral vascular beds].
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Male; Papaverine; Parasympatholytics; Perfusion; Rats; Tail; Theophylline; Verapamil | 1976 |
Adenosine modulation of calcium currents in postganglionic neurones of avian cultured ciliary ganglia.
Topics: 2-Chloroadenosine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channels; Cells, Cultured; Chick Embryo; Electric Conductivity; Ganglia, Parasympathetic; Membrane Potentials; Neurons; Nifedipine; omega-Conotoxins; Peptides, Cyclic; Theophylline; Verapamil | 1992 |
Verapamil and drug metabolism by the cytochrome P450 isoform CYP1A2.
Topics: Cytochrome P-450 CYP1A2; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; Oxidoreductases; Theophylline; Verapamil | 1992 |
Influence of osmolarity of solutions used for K+ contraction on relaxant responses to pinacidil, verapamil, theophylline and terbutaline in isolated airway smooth muscle.
Topics: Animals; Guanidines; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Osmolar Concentration; Pinacidil; Potassium Chloride; Terbutaline; Theophylline; Trachea; Verapamil | 1992 |
Theophylline, fatigue, and diaphragm contractility: cellular levels of 45Ca and cAMP.
Topics: Animals; Calcium; Cyclic AMP; Diaphragm; In Vitro Techniques; Male; Muscle Contraction; Rats; Rats, Inbred Strains; Theophylline; Verapamil | 1991 |
Effects of calcitriol on stimulation of ion transport in pig jejunal mucosa.
Topics: Animals; Calbindins; Calcimycin; Calcitriol; Calcium; Calcium Channel Blockers; Chlorides; Gallic Acid; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Ion Transport; Jejunum; Rickets; S100 Calcium Binding Protein G; Sodium; Swine; Theophylline; Verapamil | 1991 |
Doxofylline differs from methylxanthines in its movement of cytosolic calcium.
Topics: Aminophylline; Animals; Binding Sites; Blood Platelets; Calcium; Cytosol; Diltiazem; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Rabbits; Rats; Rats, Inbred Strains; Spectrometry, Fluorescence; Synaptosomes; Theophylline; Verapamil | 1991 |
External ATP-induced changes in [Ca2+]i and membrane currents in mammalian atrial myocytes.
Topics: Adenosine; Adenosine Triphosphate; Animals; Calcium; Cell Membrane; Cells, Cultured; Cobalt; Guinea Pigs; Heart; Heart Atria; Kinetics; Membrane Potentials; Nickel; Theophylline; Verapamil | 1991 |
Theophylline produces an adverse effect on myocardial lactate metabolism at a therapeutic serum concentration: an effect blocked by verapamil.
Topics: Animals; Coronary Circulation; Dogs; Heart; Hemodynamics; Lactates; Lactic Acid; Myocardial Contraction; Myocardium; Oxygen Consumption; Theophylline; Verapamil | 1991 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Pinacidil; Pyrroles; Terbutaline; Theophylline; Trachea; Verapamil | 1990 |
[The relaxation of the coronary artery smooth muscles under the action of a high-potassium solution].
Topics: Animals; Cattle; Coronary Vessels; Dose-Response Relationship, Drug; In Vitro Techniques; Isotonic Solutions; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium; Propranolol; Solutions; Theophylline; Verapamil | 1990 |
Ca2+ channel blockade inhibits gallbladder ion transport.
Topics: Animals; Biological Transport; Calcium Channel Blockers; Calcium Channels; Electric Conductivity; Electrophysiology; Epithelium; Gallbladder; Male; Microscopy, Electron; Sciuridae; Theophylline; Verapamil | 1990 |
A role for adenosine calcium and ischemia in radiocontrast-induced intrarenal vasoconstriction.
Topics: Acute Kidney Injury; Adenosine; Animals; Biological Transport, Active; Calcium; Contrast Media; Diatrizoate Meglumine; Diltiazem; Dogs; Female; Ischemia; Male; Renal Circulation; Sodium; Theophylline; Vasoconstriction; Verapamil | 1990 |
Effect of K+ channel-blockers on sugar uptake by isolated chicken enterocytes.
Topics: 3-O-Methylglucose; Animals; Barium; Biological Transport, Active; Calcium; Chickens; In Vitro Techniques; Intestinal Mucosa; Methylglucosides; Methylglycosides; Potassium; Potassium Channels; Quinine; Sodium; Theophylline; Verapamil | 1990 |
Verapamil-induced inhibition of theophylline elimination in healthy humans.
Topics: Adult; Drug Interactions; Female; Half-Life; Humans; Male; Theophylline; Verapamil | 1990 |
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Relation to cAMP concentration and Ca2+ uptake.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Diterpenes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Nifedipine; Oxazoles; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide; Verapamil | 1985 |
Calcium mediation of the pig jejunal secretory response.
Topics: Animals; Bacterial Toxins; Calcimycin; Calcium; Cell Membrane Permeability; Chlorpromazine; Dantrolene; Egtazic Acid; Enterotoxins; Escherichia coli Proteins; Intestinal Mucosa; Ion Channels; Jejunum; Membrane Potentials; Swine; Theophylline; Verapamil | 1985 |
Role of extracellular calcium in the effects of substance P and neurokinin A on guinea pig trachea and human bronchus.
Topics: Animals; Bronchi; Calcium; Guinea Pigs; Humans; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Neurokinin A; Neuropeptides; Nicardipine; Substance P; Theophylline; Trachea; Verapamil | 1988 |
Elevation of angiotensin converting enzyme by 3-isobutyl-1-methylxanthine in cultured endothelial cells: a possible role for calmodulin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calmodulin; Cattle; Cells, Cultured; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Egtazic Acid; Endothelium, Vascular; Imidazoles; Indomethacin; Peptidyl-Dipeptidase A; Propranolol; Theophylline; Trifluoperazine; Verapamil; Xanthines | 1988 |
Parotid kallikrein secretion in the rat after alterations of electrolyte transport and cAMP activity.
Topics: Amiloride; Animals; Bucladesine; Calcimycin; Cyclic AMP; Ion Channels; Kallikreins; Male; Monensin; Parotid Gland; Potassium; Rats; Rats, Inbred Strains; Sodium; Theophylline; Verapamil; Water-Electrolyte Balance | 1985 |
Involvement of calcium in the release of immunoreactive beta-endorphin-like peptide from dispersed cells of the neurointermediate lobe of the rat pituitary gland.
Topics: 1-Methyl-3-isobutylxanthine; Animals; beta-Endorphin; Bucladesine; Calcimycin; Calcium; Cholera Toxin; Colforsin; Cyclic AMP; Diterpenes; Endorphins; In Vitro Techniques; Isoproterenol; Pituitary Gland; Rats; Theophylline; Verapamil | 1985 |
The influence of verapamil on theophylline serum concentrations.
Topics: Adult; Fluorescence Polarization; Fluorescent Antibody Technique; Humans; Theophylline; Verapamil | 1989 |
Inhibition of theophylline elimination in rabbits by verapamil.
Topics: Animals; Female; Male; Rabbits; Theophylline; Verapamil | 1989 |
Role of theophylline, verapamil, and diltiazem on rat fatigued diaphragmatic muscle in vitro.
Topics: Animals; Diaphragm; Diltiazem; In Vitro Techniques; Male; Rats; Rats, Inbred Strains; Respiratory Muscles; Theophylline; Verapamil | 1989 |
Theophylline-induced ventricular tachycardia in a patient with chronic lung disease. Sensitivity to verapamil.
Topics: Aged; Electrocardiography; Humans; Male; Pulmonary Emphysema; Tachycardia; Theophylline; Verapamil | 1989 |
Update on rifampin drug interactions.
Topics: Adrenergic beta-Antagonists; Cyclosporins; Digoxin; Drug Interactions; Humans; Ketoconazole; Phenytoin; Rifampin; Theophylline; Verapamil | 1987 |
Influence of gastrointestinal peptides on bile acid transport by isolated rat hepatocytes.
Topics: Animals; Bile Acids and Salts; Bombesin; Cells, Cultured; Dose-Response Relationship, Drug; Liver; Male; Rats; Rats, Inbred Strains; Somatostatin; Taurocholic Acid; Theophylline; Thyrotropin-Releasing Hormone; Vasoactive Intestinal Peptide; Verapamil | 1987 |
Diltiazem, verapamil, and nifedipine inhibit theophylline-enhanced diaphragmatic contractility.
Topics: Animals; Biological Transport; Calcium; Calcium Channel Blockers; Diaphragm; Diltiazem; Male; Muscle Contraction; Nifedipine; Rats; Rats, Inbred Strains; Theophylline; Verapamil | 1989 |
Mechanisms of release of prolactin from fowl anterior pituitary glands incubated in vitro: effects of calcium and cyclic adenosine monophosphate.
Topics: Animals; Bucladesine; Calcium; Chickens; Cyclic AMP; Egtazic Acid; In Vitro Techniques; Pituitary Gland, Anterior; Potassium; Prolactin; Theophylline; Thyrotropin-Releasing Hormone; Verapamil | 1985 |
Ca2+ channel blockers stimulate ileal and colonic water absorption.
Topics: Animals; Atropine; Biological Transport; Body Water; Calcium; Calcium Channel Blockers; Carbachol; Chlorides; Colon; Cyclic AMP; Drug Interactions; Ileum; In Vitro Techniques; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption; Male; Nifedipine; Rabbits; Rats; Rats, Inbred Strains; Sodium; Theophylline; Time Factors; Verapamil | 1985 |
Inhibition of human platelet aggregation by parathyroid hormone. Is cyclic AMP implicated?
Topics: Adenylyl Cyclases; Blood Platelets; Calcimycin; Calcium; Cyclic AMP; Humans; In Vitro Techniques; Parathyroid Hormone; Platelet Aggregation; Theophylline; Thromboxane B2; Uremia; Verapamil | 1985 |
Breakdown of phosphoinositides in airway smooth muscle: lack of influence of anti-asthmatic drugs.
Topics: Animals; Carbachol; Cattle; Dexamethasone; Histamine; Hydrolysis; Isoproterenol; Muscle Contraction; Phosphatidylinositols; Phospholipases; Quinacrine; Theophylline; Trachea; Verapamil | 1987 |
ATP-secretion occurs as an initial response in collagen induced platelet activation.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Arachidonic Acid; Arachidonic Acids; Aspirin; Blood Platelets; Collagen; Edetic Acid; Egtazic Acid; Humans; Kinetics; Platelet Aggregation; Theophylline; Verapamil; Yohimbine | 1986 |
Slowing of relaxation in the fatiguing hamster diaphragm is enhanced by theophylline.
Topics: Animals; Caffeine; Calcium; Cricetinae; Diaphragm; In Vitro Techniques; Mesocricetus; Muscle Contraction; Muscle Relaxation; Theophylline; Verapamil | 1988 |
Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans.
Topics: Adult; Antipyrine; Cytochrome P-450 Enzyme Inhibitors; Diltiazem; Drug Interactions; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Theophylline; Verapamil | 1988 |
Characterisation of theophylline metabolism by human liver microsomes. Inhibition and immunochemical studies.
Topics: Adult; Benzoflavones; Caffeine; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dextropropoxyphene; Humans; Immunologic Techniques; In Vitro Techniques; Isoenzymes; Kinetics; Microsomes, Liver; Middle Aged; Mixed Function Oxygenases; Theophylline; Verapamil | 1988 |
Interaction of theophylline, verapamil, and diltiazem on hamster diaphragm muscle force in vitro.
Topics: Animals; Calcium; Cricetinae; Diaphragm; Diltiazem; Drug Interactions; In Vitro Techniques; Mesocricetus; Muscles; Theophylline; Verapamil | 1988 |
Compatibility of premixed theophylline and verapamil intravenous admixtures.
Topics: Chromatography, High Pressure Liquid; Drug Combinations; Drug Incompatibility; Drug Stability; Humans; Hydrogen-Ion Concentration; Lung Diseases, Obstructive; Theophylline; Verapamil | 1988 |
Iodide transport in rat small intestine: dependence on calcium.
Topics: Animals; Biological Transport; Calcium; In Vitro Techniques; Intestine, Small; Iodides; Male; Rats; Rats, Inbred Strains; Theophylline; Trifluoperazine; Verapamil | 1987 |
Relaxant effects of xanthines, a beta 2-receptor agonist and Ca2+ antagonists in guinea-pig tracheal preparations contracted by potassium or carbachol.
Topics: Animals; Bronchodilator Agents; Carbachol; Female; Guinea Pigs; Male; Muscle, Smooth; Nimodipine; Parasympatholytics; Potassium; Terbutaline; Theophylline; Trachea; Verapamil; Xanthines | 1986 |
Stimulation of insulin release by an organic calcium agonist.
Topics: Animals; Barium; Calcium; Dose-Response Relationship, Drug; Glucose; Insulin; Islets of Langerhans; Pyridines; Rats; Theophylline; Verapamil | 1985 |
"On" and "off" responses of guinea pig ureter.
Topics: Animals; Calcium; Edetic Acid; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Magnesium; Male; Muscle Contraction; Muscle, Smooth; Sodium; Theophylline; Ureter; Verapamil | 1985 |
Inhibitory effect of quinacrine on myocardial reactive hyperemia in the dog.
Topics: Acetylcholine; Adenosine; Animals; Blood Flow Velocity; Catechols; Coronary Circulation; Dogs; Female; Heart Rate; Hyperemia; Indomethacin; Male; Masoprocol; Pyrazoles; Quinacrine; Regional Blood Flow; Theophylline; Verapamil | 1985 |
Calcium-dependence of sugar transport in rat small intestine.
Topics: Animals; Biological Transport, Active; Calcium; Calmodulin; Galactose; Imines; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Male; Rats; Rats, Inbred Strains; Theophylline; Trifluoperazine; Verapamil | 1985 |
Ketamine-inhibition of calcium-induced contractions in depolarized rat uterus: a comparison with other calcium antagonists.
Topics: Animals; Calcium; Calcium Channel Blockers; Female; In Vitro Techniques; Ketamine; Neuromuscular Depolarizing Agents; Papaverine; Potassium; Rats; Rats, Inbred Strains; Theophylline; Uterine Contraction; Verapamil | 1985 |
Atrial arrhythmias exacerbated by theophylline. Response to verapamil and evidence for triggered activity in man.
Topics: Aged; Digoxin; Electrocardiography; Female; Heart Atria; Humans; Lung Diseases, Obstructive; Recurrence; Tachycardia; Theophylline; Verapamil | 1985 |
[On the effect of various cardiac drugs on the connective tissue].
Topics: Animals; Benzoates; Connective Tissue; Coumarins; Dipyridamole; Glycolates; Glycosaminoglycans; Granulation Tissue; Heart; Histological Techniques; Male; Myocardium; Nicotinic Acids; Prenylamine; Propranolol; Rats; Stimulation, Chemical; Sulfur Isotopes; Sympatholytics; Theophylline; Vasodilator Agents; Verapamil | 1967 |
Proceedings: Prevention by Ca-antagonistic compounds (verapamil, D 600) of coronary smooth muscle contractures due to treatment with cardiac glycosides.
Topics: Animals; Caffeine; Calcium; Cardiac Glycosides; Coronary Vessels; Dipyridamole; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Prenylamine; Theophylline; Verapamil | 1974 |
Pituitary 45 Ca ion uptake and release of ACTH, GH, and TSH: effect of verapamil.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Calcium Radioisotopes; Cyclic AMP; Depression, Chemical; Growth Hormone; Hypothalamus; In Vitro Techniques; Male; Ouabain; Pituitary Gland; Potassium; Rats; Theophylline; Thyrotropin; Thyrotropin-Releasing Hormone; Tissue Extracts; Vasopressins; Verapamil | 1974 |
[Effect of Verapamil on the metabolism of myocardium].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Anti-Arrhythmia Agents; Asphyxia; Blood Glucose; Blood Pressure; Creatine; Depression, Chemical; Dipyridamole; Dogs; Ethanolamines; Fatty Acids; Heart Rate; Hypoxia; Lactates; Male; Mice; Myocardium; Nitriles; Norepinephrine; Oxidation-Reduction; Phosphates; Prenylamine; Propranolol; Pyruvates; Rats; Stimulation, Chemical; Sympatholytics; Sympathomimetics; Theophylline; Tyramine; Vasodilator Agents; Verapamil | 1970 |
[Inhibition of adenosine uptake and stimulation of its effect on isolated hearts of warm-blooded animals by coronary active substances].
Topics: Alkaloids; Allopurinol; Animals; Carbon Isotopes; Cocaine; Depression, Chemical; Dipyridamole; Drug Synergism; Ethylenediamines; Guinea Pigs; Heart Rate; In Vitro Techniques; Myocardium; Nitroglycerin; Nucleosides; Ouabain; Papaverine; Prenylamine; Probenecid; Pyridines; Reserpine; Stimulation, Chemical; Theophylline; Triamterene; Vasodilator Agents; Verapamil | 1969 |
[Therapy of primary pulmonary hypertension].
Topics: Acetylcholine; Amino Alcohols; Carbachol; Child; Diazepam; Diazoxide; Female; Humans; Hypertension, Pulmonary; Isoproterenol; Isosorbide Dinitrate; Neostigmine; Nitroglycerin; Pentaerythritol Tetranitrate; Rest; Theophylline; Tolazoline; Verapamil | 1970 |
Inhibition of prolactin and growth hormone secretion by nickel.
Topics: Animals; Barium; Bucladesine; Calcium; Growth Hormone; Growth Hormone-Releasing Hormone; Lanthanum; Male; Nickel; Pituitary Gland; Prolactin; Rats; Rats, Inbred Strains; Theophylline; Time Factors; Verapamil | 1984 |
The involvement of calcium in the intestinal response to secretagogues in the rat.
Topics: Acetylcholine; Animals; Bucladesine; Calcimycin; Calcium; Chlorides; Dinoprostone; Egtazic Acid; Gallic Acid; In Vitro Techniques; Intestinal Mucosa; Intestinal Secretions; Intestines; Male; Membrane Potentials; Potassium; Prostaglandins E; Rats; Serotonin; Sodium; Theophylline; Trifluoperazine; Verapamil | 1984 |
Diazoxide and D600 inhibition of insulin release. Distinct mechanisms explain the specificity for different stimuli.
Topics: Adrenergic alpha-Antagonists; Animals; Arginine; Calcium; Depression, Chemical; Diazoxide; Epinephrine; Gallopamil; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Lysine; Male; Rats; Rats, Inbred Strains; Theophylline; Verapamil | 1982 |
Chymotrypsin, ileal chloride transport, and neurotransmitters.
Topics: Animals; Chlorides; Chymotrypsin; Dinoprostone; Electric Stimulation; Ileum; Intestinal Mucosa; Ion Channels; Neurotransmitter Agents; Ouabain; Prostaglandins E; Rabbits; Theophylline; Trifluoperazine; Vasoactive Intestinal Peptide; Verapamil | 1984 |
Studies on the mechanism of action of glucagon in strips of rabbit renal artery.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic AMP; Female; Glucagon; In Vitro Techniques; Indomethacin; Male; Papaverine; Phosphodiesterase Inhibitors; Proadifen; Rabbits; Renal Artery; Theophylline; Vasodilator Agents; Verapamil | 1980 |
Inhibition of anaphylactic histamine release from heterologously sensitized mast cells: differential effects of drugs which interfere with calcium influx.
Topics: Animals; Antigens; Biological Transport; Calcium; Cromolyn Sodium; Histamine Release; Immunization; Immunoglobulin E; Male; Mast Cells; Mice; Mice, Inbred BALB C; Quercetin; Rats; Rats, Inbred Strains; Theophylline; Verapamil | 1981 |
Effect of calcium antagonists in experimental asthma.
Topics: Anaphylaxis; Animals; Asthma; Calcium Channel Blockers; Depression, Chemical; Disease Models, Animal; Epitopes; Guinea Pigs; Histamine Release; Immunization, Passive; Male; Muscle Contraction; Muscle, Smooth; Ovalbumin; Theophylline; Trachea; Verapamil | 1982 |
beta-Adrenergic stimulation of the adenosine 3',5'-monophosphate system regulated by cholinergic stimuli in the prostate.
Topics: 1-Methyl-3-isobutylxanthine; Acetylcholine; Animals; Atropine; Calcimycin; Calcium; Cell Membrane; Cyclic AMP; Hexamethonium; Hexamethonium Compounds; Isoproterenol; Male; Parasympathetic Nervous System; Prostate; Rats; Receptors, Adrenergic; Receptors, Adrenergic, beta; Tetracaine; Theophylline; Verapamil | 1983 |
Methylxanthines stimulate calcium transport and inhibit cyclic nucleotide phosphodiesterases in abalone sperm.
Topics: 1-Methyl-3-isobutylxanthine; Acrosome; Animals; Biological Transport; Calcium; Cyclic AMP; Male; Mollusca; Phosphodiesterase Inhibitors; Spermatozoa; Theophylline; Verapamil | 1983 |
Calcium dependence of serotonin-induced changes in rabbit ileal electrolyte transport.
Topics: Animals; Biological Transport, Active; Calcium; Chlorides; Ileum; Intestinal Mucosa; Ion Channels; Male; Rabbits; Serotonin; Sodium; Theophylline; Verapamil | 1980 |
Effect of verapamil on the hydroosmotic response to antidiuretic hormone in toad urinary bladder.
Topics: Animals; Bufo marinus; Calcium; Cyclic AMP; Female; In Vitro Techniques; Phosphoric Diester Hydrolases; Theophylline; Urinary Bladder; Vasopressins; Verapamil; Water | 1980 |
[Certain mechanisms of the effect of EDTA on thrombocyte aggregation].
Topics: Blood Platelets; Bucladesine; Calcium; Drug Interactions; Edetic Acid; Egtazic Acid; Humans; Platelet Aggregation; Tetracaine; Theophylline; Verapamil | 1981 |
Pharmacologically induced changes in human beta-chorionic gonadotropin (beta-hCG) synthesis by human placenta in organ culture.
Topics: Bucladesine; Chorionic Gonadotropin; Dose-Response Relationship, Drug; Ethanolamines; Female; Fenoterol; Humans; Organ Culture Techniques; Placenta; Pregnancy; Theophylline; Time Factors; Verapamil | 1982 |
Role of calcium in cAMP-mediated effects in the elasmobranch rectal gland.
Topics: Amphotericin B; Animals; Calcimycin; Calcium; Cyclic AMP; Dogfish; Ouabain; Oxygen Consumption; Receptors, Drug; Salt Gland; Sharks; Sodium; Sodium-Potassium-Exchanging ATPase; Theophylline; Verapamil | 1983 |
A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat.
Topics: Animals; Carrageenan; Dexamethasone; Dose-Response Relationship, Drug; Edema; Hindlimb; Indomethacin; Male; Muscles; Phentolamine; Platelet Activating Factor; Rats; Rats, Inbred Strains; Regional Blood Flow; Theophylline; Verapamil; Yohimbine | 1984 |
Extracellular pH and tension during ischemia in the isolated rabbit ventricle.
Topics: Acidosis, Respiratory; Animals; Catecholamines; Coronary Disease; Extracellular Space; Heart Rate; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Myocardial Contraction; Rabbits; Temperature; Theophylline; Verapamil | 1984 |
Severe theophylline toxicity. Role of conservative measures, antiarrhythmic agents, and charcoal hemoperfusion.
Topics: Aged; Heart Rate; Hemoperfusion; Humans; Hypotension; Kinetics; Male; Middle Aged; Propranolol; Seizures; Tachycardia; Theophylline; Verapamil | 1984 |
The inhibitory effects of D-600 and cobalt on theophylline-mediated calcitonin secretion and calcium distribution in porcine thyroid slices.
Topics: Animals; Calcitonin; Calcium; Cobalt; Gallopamil; In Vitro Techniques; Mannitol; Swine; Theophylline; Thyroid Gland; Verapamil | 1980 |
Optic cup formation: a calcium-regulated process.
Topics: Animals; Caffeine; Calcimycin; Calcium; Chick Embryo; Eye; Microscopy, Fluorescence; Organ Culture Techniques; Retina; Theophylline; Trifluoperazine; Verapamil | 1982 |
The effect of verapamil, lanthanum and local anesthetics of serotonin release from rabbit platelets.
Topics: Alprostadil; Anesthetics, Local; Animals; Blood Platelets; Lanthanum; Prostaglandins E; Rabbits; Serotonin; Theophylline; Thrombin; Time Factors; Verapamil | 1982 |
Calcium dependence of basal electrolyte transport in rabbit ileum.
Topics: Animals; Biological Transport; Calcium; Electrolytes; Ileum; In Vitro Techniques; Intestinal Mucosa; Kinetics; Male; Rabbits; Theophylline; Verapamil | 1982 |
Caffeine reversal of length-dependent changes in myocardial contractile state in the cat.
Topics: Animals; Caffeine; Calcium; Cats; Dose-Response Relationship, Drug; Manganese; Myocardial Contraction; Theophylline; Time Factors; Verapamil | 1980 |
Inhibition by cromakalim, pinacidil, terbutaline, theophylline and verapamil of non-cholinergic nerve-mediated contractions of guinea-pig isolated bronchi.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Pinacidil; Potassium Channels; Pyrroles; Substance P; Synaptic Transmission; Terbutaline; Theophylline; Verapamil | 1994 |
Method to estimate the rate and extent of intestinal absorption in conscious rats using an absorption probe and portal blood sampling.
Topics: Animals; Biological Availability; Intestinal Absorption; Intestinal Mucosa; Male; Mathematics; Portal Vein; Rats; Rats, Sprague-Dawley; Theophylline; Time Factors; Verapamil | 1995 |
Effects of alkylxanthines on contractility of diaphragm fibres isolated from normal and sensitized guinea-pigs.
Topics: Adenosine; Animals; Bronchodilator Agents; Caffeine; Calcium; Culture Media; Dantrolene; Diaphragm; Electric Stimulation; Extracellular Space; Female; Guinea Pigs; Immunization; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Serum Albumin, Bovine; Theobromine; Theophylline; Verapamil; Xanthines | 1993 |
The effects of phorbol 12,13-diacetate on responses of guinea-pig isolated trachea to methylxanthines, isoprenaline and ryanodine.
Topics: Animals; Caffeine; Calcium Chloride; Cold Temperature; Drug Interactions; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle Spasticity; Muscle, Smooth; Phorbol Esters; Potassium; Ryanodine; Theophylline; Trachea; Verapamil; Xanthines | 1994 |
Modulation of cyclic AMP-dependent protein kinase activity by drugs affecting human platelet aggregation.
Topics: Aspirin; Blood Platelets; Cyclic AMP-Dependent Protein Kinases; Diltiazem; Humans; Kinetics; Masoprocol; Platelet Aggregation; Theophylline; Verapamil | 1993 |
Effects of theophylline, verapamil, and mannitol on oxygen consumption of ischemic rat kidneys.
Topics: Animals; Ischemia; Kidney; Male; Mannitol; Oxygen Consumption; Rats; Rats, Wistar; Theophylline; Verapamil | 1993 |
Bioequivalence revisited: non-parametric analysis of two-period cross-over studies.
Topics: Algorithms; Analysis of Variance; Angina Pectoris; Bepridil; Computer Simulation; Confidence Intervals; Delayed-Action Preparations; Double-Blind Method; Humans; Isosorbide Dinitrate; Male; Mathematical Computing; Reference Values; Software; Theophylline; Therapeutic Equivalency; Verapamil | 1993 |
Renin processing in cultured juxtaglomerular cells of the hydronephrotic mouse kidney.
Topics: Angiotensin II; Animals; Colforsin; Cytoplasmic Granules; Female; Hydronephrosis; Immunoenzyme Techniques; Immunohistochemistry; Juxtaglomerular Apparatus; Mice; Mice, Inbred BALB C; Microscopy, Electron; Organ Culture Techniques; Organelles; Renin; Theophylline; Verapamil | 1993 |
[Severe theophylline poisoning in an infant: management in a pediatric emergency care unit].
Topics: Bronchiolitis; Dose-Response Relationship, Drug; Electroshock; Emergency Service, Hospital; Female; Humans; Infant; Infusions, Intravenous; Poisoning; Respiratory Insufficiency; Theophylline; Verapamil | 1993 |
Possible involvement of multiple P-glycoprotein-mediated efflux systems in the transport of verapamil and other organic cations across rat intestine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile Acids and Salts; Biological Transport, Active; Cefazolin; Chlorpromazine; Ileum; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Jejunum; Male; Propantheline; Rats; Rats, Sprague-Dawley; Theophylline; Verapamil | 1995 |
Mechanism of theophylline-induced inotropic effects on foreshortened canine diaphragm.
Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Diaphragm; Dogs; In Vitro Techniques; Muscle Contraction; Ryanodine; Sarcoplasmic Reticulum; Stimulation, Chemical; Theophylline; Verapamil | 1995 |
Reversal of acute theophylline toxicity by calcium channel blockers in dogs and rats.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Bronchodilator Agents; Calcium; Calcium Channel Blockers; Death, Sudden, Cardiac; Diltiazem; Disease Models, Animal; Dogs; Electrocardiography; Female; Heart Rate; Hypotension; Infusions, Intravenous; Injections, Intraperitoneal; Male; Nifedipine; Phosphodiesterase Inhibitors; Random Allocation; Rats; Rats, Sprague-Dawley; Respiration; Theophylline; Verapamil | 1996 |
A high cholesterol diet blocks the effect of calcium channel blockers on the uptake of sugars in rabbit intestine.
Topics: Animals; Biological Transport; Body Weight; Calcium Channel Blockers; Carbohydrates; Cholesterol, Dietary; Dose-Response Relationship, Drug; Drug Interactions; Glucose; Intestinal Absorption; Jejunum; Male; Nisoldipine; Phosphodiesterase Inhibitors; Rabbits; Theophylline; Verapamil | 1997 |
Cyclic AMP stimulates the cyclic GMP egression pump in human erythrocytes: effects of probenecid, verapamil, progesterone, theophylline, IBMX, forskolin, and cyclic AMP on cyclic GMP uptake and association to inside-out vesicles.
Topics: 1-Methyl-3-isobutylxanthine; Biological Transport, Active; Colforsin; Cyclic AMP; Cyclic GMP; Dimethyl Sulfoxide; Erythrocyte Membrane; Humans; Ion Pumps; Probenecid; Progesterone; Theophylline; Verapamil | 1998 |
Studies on modifying the tackiness and drug release of Kollicoat EMM 30 D coatings.
Topics: Chemistry, Pharmaceutical; Drug Implants; Polymethacrylic Acids; Propranolol; Theophylline; Verapamil | 2003 |
On the mechanisms of post-rest adaptation in the isolated electrically driven left atria of rats.
Topics: 4-Aminopyridine; Adaptation, Physiological; Animals; Calcium; Calcium Channel Blockers; Cardiotonic Agents; Electric Stimulation; Female; Heart; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Ouabain; Potassium Channel Blockers; Rats; Rats, Sprague-Dawley; Rest; Theophylline; Vasodilator Agents; Verapamil | 2002 |
Pharmaceutical applications of shellac: moisture-protective and taste-masking coatings and extended-release matrix tablets.
Topics: Acetaminophen; Aspirin; Delayed-Action Preparations; Drug Stability; Humans; Hypromellose Derivatives; Methylcellulose; Resins, Plant; Solubility; Taste; Theophylline; Verapamil; Wettability | 2003 |
The chimpanzee (Pan troglodytes) as a pharmacokinetic model for selection of drug candidates: model characterization and application.
Topics: Acetaminophen; Adrenergic beta-Antagonists; Analgesics, Non-Narcotic; Animals; Blotting, Western; Bronchodilator Agents; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Humans; In Vitro Techniques; Male; Mass Spectrometry; Microsomes, Liver; Models, Biological; Pan troglodytes; Pharmaceutical Preparations; Pharmacokinetics; Propranolol; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Theophylline; Verapamil | 2004 |
Positive inotropic and negative chronotropic effects of proton pump inhibitors in isolated rat atrium.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Heart Atria; Imidazoles; In Vitro Techniques; Lansoprazole; Male; Milrinone; Myocardial Contraction; Omeprazole; Ouabain; Phosphodiesterase Inhibitors; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase; Theophylline; Verapamil | 2005 |
Positive inotropic effect of Murraya koenigii (Linn.) Spreng extract on an isolated perfused frog heart.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Dose-Response Relationship, Drug; Ethanol; Heart; Imidazoles; Lidocaine; Murraya; Myocardium; Phosphodiesterase Inhibitors; Piperazines; Plant Extracts; Propranolol; Purines; Ranidae; Sildenafil Citrate; Sulfones; Theophylline; Vasodilator Agents; Verapamil | 2006 |
Pancreatic islet function in omega-3 fatty acid-depleted rats: alteration of calcium fluxes and calcium-dependent insulin release.
Topics: Animals; Barium; Calcium; Cytosol; Diet; Fatty Acids, Omega-3; Female; Fish Oils; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Olive Oil; Plant Oils; Potassium; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Theophylline; Verapamil | 2006 |
Pharmacologic manipulation of the porcine ureter: Acute impact of topical drugs on ureteral diameter and peristaltic activity.
Topics: Animals; Dimethyl Sulfoxide; Electromyography; Female; Muscle, Smooth; Peristalsis; Sus scrofa; Theophylline; Ureter; Ureteroscopy; Vasodilator Agents; Verapamil | 2006 |
Milrinone and theophylline act as lower oesophageal sphincter relaxing agents: a comparative pharmacodynamic study in the rabbit.
Topics: Animals; Bronchodilator Agents; Esophageal Sphincter, Lower; Female; Male; Milrinone; Muscle Relaxation; Papaverine; Rabbits; Theophylline; Vasodilator Agents; Verapamil | 2009 |
Investigation of critical core formulation and process parameters for osmotic pump oral drug delivery.
Topics: Acetaminophen; Administration, Oral; Chemistry, Pharmaceutical; Dosage Forms; Drug Delivery Systems; Membrane Transport Proteins; Osmosis; Polyethylene Glycols; Polymers; Solubility; Tablets; Theophylline; Verapamil | 2014 |
Identification of MMP-1 and MMP-9 inhibitors from the roots of Eleutherococcus divaricatus, and the PAMPA test.
Topics: Dioxoles; Eleutherococcus; Gas Chromatography-Mass Spectrometry; Lignans; Matrix Metalloproteinase 1; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Plant Roots; Solubility; Theophylline; Triterpenes; Ursolic Acid; Verapamil | 2016 |
Evaluation of Strategies for the Assessment of Drug-Drug Interactions Involving Cytochrome P450 Enzymes.
Topics: Cytochrome P-450 CYP1A2 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Dihydralazine; Dose-Response Relationship, Drug; Drug Interactions; Humans; Microsomes, Liver; Mifepristone; Paroxetine; Theophylline; Troleandomycin; Verapamil | 2018 |