verapamil has been researched along with tamoxifen in 84 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.38) | 18.7374 |
| 1990's | 34 (40.48) | 18.2507 |
| 2000's | 18 (21.43) | 29.6817 |
| 2010's | 27 (32.14) | 24.3611 |
| 2020's | 3 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 2 |
| Pajeva, IK; Wiese, M | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Berardi, F; Colabufo, NA; Contino, M; Inglese, C; Niso, M; Perrone, R | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Arya, KR; Bid, HK; Chaturvedi, JP; Chaudhary, P; Konwar, R; Narender, T; Nayak, VL; Reddy, KP | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Choi, SH; Kazantsev, AG; Khanfar, MA; Quinti, L; Silverman, RB; Wang, H | 1 |
| Creemer, CN; Dai, M; Davis, DC; Kyei-Baffour, K; Mohammad, H; Seleem, MN; Younis, W | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Abdelghany, TM; Bayoumi, SA; Disouky, AM; El-Morsy, A; Elshafeey, A; Mancy, AS; Mayhoub, AS; Mohammad, H; Seleem, MA; Seleem, MN | 1 |
| Ghiaty, A; Hagras, M; Hegazy, YA; Mandour, MS; Mayhoub, AS; Mohammad, H; Seleem, MN | 1 |
| Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS | 1 |
| Abdelghany, TM; Elkabbany, AH; Ghiaty, A; Hagras, M; Hegazy, YA; Mayhoub, AS; Mohammad, H; Seleem, MN | 1 |
| Carpinella, MC; Gancedo, SN; González, ML; Hodnik, Ž; Kikelj, D; Laiolo, J; Lanza, PA; Peterlin Mašič, L; Tomašič, T; Vera, DMA | 1 |
| Abutaleb, NS; Elsebaei, MM; Gowher, H; Mayhoub, AS; Michie, AR; Mohammad, H; Moustafa, MM; Norvil, AB; Samir, A; Samy, H; Seleem, MN | 1 |
| Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J | 1 |
| Abutaleb, NS; Alhashimi, M; Kassab, AE; Mayhoub, AS; Mohamed, KO; Seleem, MN; Shahin, IG; Taher, AT | 1 |
| Aviram, R; Beery, E; Blau, O; Frisch, A; Levavi, H; Nordenberg, J; Novogrodsky, A; Ovadia, J; Shneyuor, Y; Wasserman, L | 1 |
| Carmichael, J; Harris, AL; Houlbrook, S; Kirk, J; Lien, EA; Philip, P; Stuart, NS; Tonkin, K | 1 |
| Batra, S; Hartley-Asp, B; Popper, LD | 1 |
| Adams, M; Andreeff, M; Berman, E; Clarkson, B; Duigou-Osterndorf, R; Godfrey, L | 1 |
| Ramu, A; Ramu, N; Rosario, LM | 1 |
| Arnold, A; Figueredo, A; Findlay, B; Goodyear, M; Jones, A; Neville, A; Normandeau, R | 1 |
| Hahn, EW; Osswald, H; Pommerenke, EW; Volm, M | 1 |
| Kessel, D | 1 |
| Dill, PL; Duarte, TE; Nagourney, RA; Su, YZ; Weisenthal, LM | 1 |
| Bertram, J; Brysch, W; Hiddemann, W; Killian, M; Kneba, M; Palfner, K; Schlingensiepen, KH | 1 |
| Jarman, M; Kelland, LR; Rowlands, MG; Sharp, SY | 1 |
| Baumgartner, G; Hamilton, G; Schirmböck, M; Sherwood, ER; Thalhammer, T; Theyer, G | 1 |
| Fink-Puches, R; Helige, C; Kerl, H; Smolle, J; Tritthart, HA | 1 |
| Gupta, V; Kamath, N; Singh, SV; Tkalcevic, GT | 1 |
| Mattern, J; Pommerenke, E; Volm, M | 1 |
| Carmichael, J; Harris, AL; Kirk, J; Stratford, IJ | 1 |
| Raderer, M; Scheithauer, W | 1 |
| Choi, JH; Chung, JB; Kim, BS; Kim, HS; Kim, JH; Kwon, OH; Lee, KS; Park, IS; Roh, JK; Yoo, NC | 1 |
| Czejka, MJ; Scheithauer, W; Schenk, T | 1 |
| Cheng, AL; Hsieh, CY; Hsieh, TS; Lai, MK; Pu, YS; Su, IJ; Tsai, TC; Tseng, NF | 1 |
| Ferry, DR; Kerr, DJ; Traunecker, H | 1 |
| Andreeff, M; Angerler, J; Drach, J; Fiegl, M; Gsur, A; Haberl, I; Hamilton, G; Huber, H; Raderer, M; Zhao, S; Zojer, N | 1 |
| Abdullah, S; Ducharme, J; Wainer, IW | 1 |
| Bracke, M; Bruyneel, E; Castronovo, V; Charlier, C; Lechanteur, C; Mareel, M | 1 |
| Cabot, MC; Cao, Ht; Geffen, V; Giuliano, AE; Han, TY; Lavie, Y; Lucci, A; Volner, A | 1 |
| Ayesh, S; Shao, YM; Stein, WD | 1 |
| Fried, K; Wainer, IW | 1 |
| Glossmann, H; Hanner, M; Moebius, FF; Reiter, RJ | 1 |
| Hejna, M; Kornek, G; Raderer, M; Scheithauer, W; Tetzner, C; Weinländer, G | 1 |
| Mintenig, GM; Monaghan, AS; Sepúlveda, FV | 1 |
| Hauser, IA; Jakob, I; Lindemann, B; Thévenod, F | 1 |
| Haberl, I; Hamilton, G; Schaufler, K; Swatonek, H; Thalhammer, T; Theyer, G; Ulsperger, E; Wenzl, E | 1 |
| Bouteiller, CL; Casellas, P; De Nys, N; Dupuy, PH; Ferrara, P; Le Fur, G; Loison, G; Paul, R; Rosenfeld, J; Silve, S | 1 |
| Gieseler, F; Gullis, E; Hasmann, M; Löser, R; Nüssler, V; Pelka-Fleisc, R; Stötzer, O; Wilmanns, W; Zwierzina, H | 1 |
| Chi, CW; Lin, HL; Liu, TY; Lui, WY | 1 |
| Minhas, S; Ralph, DJ | 1 |
| Ekhlasi-Hundrieser, M; Harrison, RA; Petrunkina, AM; Töpfer-Petersen, E | 1 |
| Feng, S; Han, J; Han, M; Li, C; Li, X; Qi, J; Qian, Q; Qiu, L; Shi, H; Yan, W | 1 |
| Kocic, I | 1 |
| Dharmala, K; Lee, CH; Yoo, JW | 1 |
| Chen, S; Hage, DS; Mallik, R; Yoo, MJ | 1 |
| Baumert, C; Hilgeroth, A | 1 |
| Cabot, MC; Chapman, JV; Gouazé-Andersson, V | 1 |
| Dekel, Y; Stein, A | 1 |
| Carson, CC; Jordan, GH; Lipshultz, LI | 1 |
| Böhmer, FD; Kirches, E; Mawrin, C; Pachow, D; Petermann, A; Wallesch, M; Wilisch-Neumann, A | 1 |
| Grewal, RK; Kalsi, H | 1 |
| Bridges, LR; Elbrecht, D; Funk, C; Hickman, JJ; Long, CJ; Martin, C; McAleer, CW; Roth, AB; Rumsey, JW; Sasserath, T; Schnepper, M; Schuler, F; Shuler, ML; Wang, Y | 1 |
| Georges, E; Limniatis, G | 1 |
10 review(s) available for verapamil and tamoxifen
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Clinical trials of agents that reverse multidrug resistance. A literature review.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Clinical Trials as Topic; Cyclosporins; Drug Resistance; Humans; Phenotype; Quinidine; Tamoxifen; Trifluoperazine; Verapamil | 1993 |
Clinical trials of P-glycoprotein reversal in solid tumours.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Quinolines; Tamoxifen; Verapamil | 1996 |
Column-switching techniques in the biomedical analysis of stereoisomeric drugs: why, how and when.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Leucovorin; Stereoisomerism; Tamoxifen; Verapamil; Zidovudine | 1997 |
The management of Peyronie's disease.
Topics: 4-Aminobenzoic Acid; Colchicine; Humans; Interferon alpha-2; Interferon-alpha; Lithotripsy; Male; Penile Induration; Penile Prosthesis; Penis; Recombinant Proteins; Tamoxifen; Verapamil; Vitamin E | 2004 |
Modulators of ion channels activated by hypotonic swelling in cardiomyocytes: new perspectives for pharmacological treatment of life-threatening arrhythmias.
Topics: Arrhythmias, Cardiac; Colforsin; Heart; Humans; Intercellular Signaling Peptides and Proteins; Ion Channels; Myocardium; Osmolar Concentration; Peptides; Spider Venoms; Tamoxifen; Verapamil | 2005 |
Recent advances in the development of P-gp inhibitors.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Coumarins; Drug Design; Drug Resistance, Neoplasm; Flavonoids; Humans; Peptides; Propafenone; Propanolamines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Quinolines; Structure-Activity Relationship; Tamoxifen; Terpenes; Verapamil | 2009 |
[Review of Peyronie's disease].
Topics: Colchicine; Humans; Injections, Intralesional; Male; Penile Induration; Tamoxifen; Verapamil; Vitamin E | 2012 |
Minimally invasive treatment of Peyronie's disease: evidence-based progress.
Topics: 4-Aminobenzoic Acid; Administration, Oral; Calcium Channel Blockers; Carnitine; Colchicine; Evidence-Based Medicine; Humans; Injections, Intralesional; Interferon-alpha; Iontophoresis; Lithotripsy; Male; Microbial Collagenase; Nicardipine; Penile Induration; Phosphodiesterase Inhibitors; Randomized Controlled Trials as Topic; Tamoxifen; Treatment Outcome; Verapamil; Vitamin E | 2014 |
3 trial(s) available for verapamil and tamoxifen
| Article | Year |
|---|---|
High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Etoposide; Female; Humans; Male; Membrane Glycoproteins; Middle Aged; Neoplasms; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1992 |
Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity.
Topics: Adult; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Brain Neoplasms; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Glioma; Humans; Male; Middle Aged; Molecular Probes; Oxidoreductases, N-Demethylating; Phenotype; Reproducibility of Results; Spectrometry, Fluorescence; Tamoxifen; Verapamil | 1996 |
Treatment of advanced colorectal cancer with doxorubicin combined with two potential multidrug-resistance-reversing agents: high-dose oral tamoxifen and dexverapamil.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Doxorubicin; Drug Resistance, Multiple; Female; Humans; Male; Middle Aged; Tamoxifen; Verapamil | 1997 |
71 other study(ies) available for verapamil and tamoxifen
| Article | Year |
|---|---|
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine | 2002 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Chemistry, Pharmaceutical; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Resistance, Multiple; Guinea Pigs; Humans; Ileum; Models, Chemical; Rhodamine 123; Tamoxifen; Verapamil | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line; Cell Line, Tumor; Epithelial Cells; Female; Humans; Inhibitory Concentration 50; Kidney; Plant Bark; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Taxoids; Taxus | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity.
Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Topics: Acetylation; Benzamides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Neuroprotective Agents; Sirtuin 2; Structure-Activity Relationship | 2014 |
Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Caco-2 Cells; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Humans; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Molecular Structure; Nitriles; Staphylococcus aureus; Structure-Activity Relationship; Vancomycin Resistance | 2015 |
Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties.
Topics: Anti-Bacterial Agents; Caco-2 Cells; Dose-Response Relationship, Drug; Humans; Hydrazines; Keratinocytes; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thiazoles | 2016 |
Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA).
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Vancomycin | 2017 |
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles | 2017 |
Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Biological Availability; Cell Line; Chemical Phenomena; Cricetinae; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxadiazoles; Rats; Solubility; Structure-Activity Relationship; Thiazoles | 2018 |
Analogues of the Lignan Pinoresinol as Novel Lead Compounds for P-glycoprotein (P-gp) Inhibitors.
Topics: | 2018 |
Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity.
Topics: Animals; Anti-Bacterial Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line; Chromatography, Liquid; Enzyme Inhibitors; Lipids; Macrophages; Mass Spectrometry; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Proton Magnetic Resonance Spectroscopy; Pyrophosphatases; Structure-Activity Relationship; Thiazoles | 2019 |
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays | 2020 |
Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Microsomes, Liver; Molecular Structure; Staphylococcal Infections; Structure-Activity Relationship; Thiazoles | 2020 |
A cell line with unusual characteristics from an ovarian carcinoma patient: modulation of sensitivity to antitumour drugs.
Topics: Adenocarcinoma; Antigens, Neoplasm; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cisplatin; Doxorubicin; Female; Humans; Karyotyping; Membrane Glycoproteins; Ovarian Neoplasms; Tamoxifen; Tumor Cells, Cultured; Verapamil; Y Chromosome | 1992 |
Effect of calcium and calcium antagonists on 45Ca influx and cellular growth of human prostatic tumor cells.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Calmodulin; Cell Division; Extracellular Space; Fibroblasts; Humans; Kinetics; Lanthanum; Male; Potassium; Prostatic Neoplasms; Tamoxifen; Trifluoperazine; Tumor Cells, Cultured; Verapamil | 1991 |
Effect of tamoxifen on cell lines displaying the multidrug-resistant phenotype.
Topics: Cell Division; Daunorubicin; Drug Resistance; Flow Cytometry; Humans; Kinetics; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Phenotype; Tamoxifen; Tumor Cells, Cultured; Verapamil; Vinblastine | 1991 |
Circumvention of multidrug-resistance in P388 cells is associated with a rise in the cellular content of phosphatidylcholine.
Topics: Animals; Cell Membrane; Cell Membrane Permeability; Choline; Digitonin; Dipyridamole; Drug Resistance; Fura-2; Ionomycin; Leukemia P388; Lipids; Phosphatidylcholines; Potassium Chloride; Tamoxifen; Tumor Cells, Cultured; Valinomycin; Verapamil | 1991 |
Addition of verapamil and tamoxifen to the initial chemotherapy of small cell lung cancer. A phase I/II study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Drug Resistance; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Tamoxifen; Time Factors; Verapamil; Vincristine | 1990 |
Activity of various amphiphilic agents in reversing multidrug resistance of L 1210 cells.
Topics: Animals; Drug Resistance; Ethylamines; Hycanthone; Leukemia L1210; Phenotype; Piperidines; Quinidine; Quinine; Tamoxifen; Trifluoperazine; Verapamil | 1990 |
Interactions among membrane transport systems: anthracyclines, calcium antagonists and anti-estrogens.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Calcium Channel Blockers; Daunorubicin; Doxorubicin; Drug Resistance; Estrogen Antagonists; Kinetics; Leukemia P388; Mice; Naphthacenes; Nifedipine; Nitrendipine; Tamoxifen; Verapamil | 1986 |
Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C.
Topics: Cell Survival; Chlorpromazine; Drug Resistance; Drug Synergism; Haloperidol; Humans; Imipramine; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Lidocaine; Protein Kinase C; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1987 |
Reversal of multiple drug resistance in vitro by phosphorothioate oligonucleotides and ribozymes.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Cell Division; Doxorubicin; Drug Resistance, Multiple; Genes, Neoplasm; Humans; Molecular Sequence Data; Neoplasm Proteins; Oligonucleotides, Antisense; RNA, Catalytic; RNA, Messenger; RNA, Neoplasm; Tamoxifen; Thionucleotides; Tumor Cells, Cultured; Verapamil | 1995 |
Effects of a new antioestrogen, idoxifene, on cisplatin- and doxorubicin-sensitive and -resistant human ovarian carcinoma cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calmodulin; Cisplatin; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Estrogen Antagonists; Female; Humans; Imidazoles; Ovarian Neoplasms; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1994 |
Role of the MDR-1-encoded multiple drug resistance phenotype in prostate cancer cell lines.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Doxorubicin; Drug Resistance; Humans; Male; Membrane Glycoproteins; Phenotype; Prostatic Neoplasms; Rhodamine 123; Rhodamines; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1993 |
Inhibition of melanoma cell directional migration in vitro via different cellular targets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aminoimidazole Carboxamide; Animals; Calcium Channel Blockers; Cell Division; Cell Movement; Dequalinium; Flunarizine; GTP-Binding Proteins; Isoquinolines; Melanoma, Experimental; Mice; Piperazines; Protein Kinase C; Signal Transduction; Tamoxifen; Triazoles; Tumor Cells, Cultured; Verapamil | 1993 |
Potentiation of tamoxifen activity by verapamil in a human breast cancer cell line.
Topics: Breast Neoplasms; Cell Division; Cell Survival; Drug Synergism; Female; Humans; Protein Kinase C; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1994 |
Modulation of doxorubicin-toxicity by tamoxifen in multidrug-resistant tumor cells in vitro and in vivo.
Topics: Animals; Cell Line; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Female; Leukemia L1210; Mice; Mice, Inbred Strains; Tamoxifen; Verapamil | 1994 |
Selective toxicity of TGF-alpha-PE40 to EGFR-positive cell lines: selective protection of low EGFR-expressing cell lines by EGF.
Topics: Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cell Division; Cell Line; Cyclosporine; Dose-Response Relationship, Drug; Drug Interactions; Epidermal Growth Factor; ErbB Receptors; Exotoxins; Female; Humans; Lung Neoplasms; Recombinant Fusion Proteins; Recombinant Proteins; Tamoxifen; Transforming Growth Factor alpha; Tumor Cells, Cultured; Verapamil | 1994 |
Combined use of tamoxifen, cyclosporin A, and verapamil for modulating multidrug resistance in human hepatocellular carcinoma cell lines.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cyclosporine; Drug Resistance; Humans; Liver Neoplasms; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1993 |
[The combination of epirubicin with d-verapamil and/or tamoxifen in cell cultures].
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Screening Assays, Antitumor; Epirubicin; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1993 |
Combined cytotoxic effects of tamoxifen and chemotherapeutic agents on bladder cancer cells: a potential use in intravesical chemotherapy.
Topics: Administration, Intravesical; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Cell Division; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Sequence Data; Rhodamine 123; Rhodamines; Tamoxifen; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Verapamil | 1996 |
Involvement of P-glycoprotein in the transmembrane transport of interleukin-2 (IL-2), IL-4, and interferon-gamma in normal human T lymphocytes.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Endocytosis; Humans; Ileal Neoplasms; Ileocecal Valve; Interferon-gamma; Interleukin-2; Interleukin-4; Lymphocyte Activation; Phytohemagglutinins; Recombinant Proteins; T-Lymphocytes; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1996 |
Enhancement of tamoxifen-induced E-cadherin function by Ca2+ channel antagonists in human breast cancer MCF7/6 cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cadherins; Calcium Channel Agonists; Calcium Channel Blockers; Cell Aggregation; Humans; Nifedipine; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1996 |
Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells.
Topics: Ceramides; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glycosphingolipids; Glycosylation; Humans; Meperidine; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1997 |
Mutually co-operative interactions between modulators of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Daunorubicin; Drug Resistance, Multiple; Drug Synergism; Kinetics; Leukemia P388; Mefloquine; Tamoxifen; Tumor Cells, Cultured; Verapamil; Vinblastine | 1997 |
High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase.
Topics: Animals; Binding Sites; Brain; Calcium Channel Blockers; Clomiphene; Estrogen Antagonists; Excitatory Amino Acid Antagonists; Fertility Agents, Female; Fungicides, Industrial; Guinea Pigs; Hypolipidemic Agents; Isoquinolines; Isotope Labeling; Microsomes; Microsomes, Liver; Morpholines; Pentazocine; Piperidines; Receptors, sigma; Saccharomyces cerevisiae; Stereoisomerism; Steroid Isomerases; Tamoxifen; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol; Verapamil | 1997 |
Outwardly rectifying Cl- channel in guinea pig small intestinal villus enterocytes: effect of inhibitors.
Topics: Adenosine Triphosphate; Animals; Anions; Cell Membrane; Cell Membrane Permeability; Chloride Channels; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Intestine, Small; Male; Membrane Potentials; Nitrobenzoates; Patch-Clamp Techniques; Tamoxifen; Verapamil | 1997 |
MDR1 in taste buds of rat vallate papilla: functional, immunohistochemical, and biochemical evidence.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Connective Tissue Cells; Cyclosporine; Epithelial Cells; Female; Fluoresceins; Fluorescent Dyes; Immunoglobulin G; In Vitro Techniques; Kinetics; Male; Microscopy, Fluorescence; Rats; Rats, Sprague-Dawley; Tamoxifen; Taste Buds; Tongue; Verapamil | 1998 |
P-glycoprotein-mediated multidrug resistance is modulated by pretreatment with chemosensitizers in HCT-8 carcinoma cells in vitro.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Ileal Neoplasms; Ileocecal Valve; Kinetics; Phosphorylation; Rhodamine 123; Rhodamines; Tamoxifen; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Verapamil; Vinblastine | 1998 |
Both the immunosuppressant SR31747 and the antiestrogen tamoxifen bind to an emopamil-insensitive site of mammalian Delta8-Delta7 sterol isomerase.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Cell Culture Techniques; Cyclohexanes; Estrogen Antagonists; Humans; Immunosuppressive Agents; Mice; Saccharomyces cerevisiae; Steroid Isomerases; Tamoxifen; Transformation, Genetic; Verapamil | 1998 |
In vitro efficacy of known P-glycoprotein modulators compared to droloxifene E and Z: studies on a human T-cell leukemia cell line and their resistant variants.
Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Division; Cyclosporins; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Leukemia, T-Cell; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Tamoxifen; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Verapamil | 1998 |
Up-regulation of multidrug resistance transporter expression by berberine in human and murine hepatoma cells.
Topics: Animals; Antineoplastic Agents, Hormonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Berberine; Carcinoma, Hepatocellular; Drugs, Chinese Herbal; Humans; Liver Neoplasms; Liver Neoplasms, Experimental; Tamoxifen; Tumor Cells, Cultured; Up-Regulation; Verapamil | 1999 |
Role of volume-stimulated osmolyte and anion channels in volume regulation by mammalian sperm.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Cell Size; Chloride Channels; Gramicidin; Hypotonic Solutions; Male; Nitrobenzoates; Osmotic Pressure; Spermatozoa; Sus scrofa; Tamoxifen; Taurine; Verapamil | 2004 |
[In vitro reversal of homoharringtonine resistance by the combination of tamoxifen and verapamil].
Topics: Animals; Drug Resistance, Neoplasm; Drug Synergism; Harringtonines; Homoharringtonine; Humans; Inhibitory Concentration 50; K562 Cells; Tamoxifen; Verapamil | 1997 |
Development of chitosan-SLN microparticles for chemotherapy: in vitro approach through efflux-transporter modulation.
Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Biological Transport; Chitosan; Drug Carriers; Drug Delivery Systems; Drug Therapy; Isothiocyanates; Lipids; Nanoparticles; Nifedipine; Particle Size; Tamoxifen; Verapamil | 2008 |
Studies of verapamil binding to human serum albumin by high-performance affinity chromatography.
Topics: Binding Sites; Binding, Competitive; Chromatography, Affinity; Drug Interactions; Humans; Protein Binding; Serum Albumin; Stereoisomerism; Tamoxifen; Tryptophan; Verapamil; Warfarin | 2008 |
Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Cell Survival; Ceramides; Cyclosporine; Cytotoxins; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Tamoxifen; Uterine Cervical Neoplasms; Verapamil | 2010 |
Re-evaluation of cytostatic therapies for meningiomas in vitro.
Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Dacarbazine; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Erlotinib Hydrochloride; Humans; Hydroxyurea; Losartan; Meningeal Neoplasms; Meningioma; Metformin; Mifepristone; Neurofibromin 2; Promoter Regions, Genetic; Quinazolines; Radiation Tolerance; Tamoxifen; Temozolomide; Tumor Suppressor Proteins; Verapamil | 2014 |
Interaction of mouse intestinal P-glycoprotein with oral antidiabetic drugs and its inhibitors.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Transport, Active; Cyclohexanes; Fatty Acids, Unsaturated; Hypoglycemic Agents; Intestinal Mucosa; Mice; Molecular Docking Simulation; Piperidines; Polyunsaturated Alkamides; Protein Binding; Sesquiterpenes; Tamoxifen; Verapamil | 2015 |
Multi-organ system for the evaluation of efficacy and off-target toxicity of anticancer therapeutics.
Topics: Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Diclofenac; Drug Evaluation, Preclinical; Humans; Imatinib Mesylate; Lab-On-A-Chip Devices; Tamoxifen; Verapamil | 2019 |
Down-regulation of ABCB1 by collateral sensitivity drugs reverses multidrug resistance and up-regulates enolase I.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Breast Neoplasms; Cell Line, Tumor; Down-Regulation; Drug Collateral Sensitivity; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Phosphopyruvate Hydratase; Tamoxifen; Verapamil | 2022 |