verapamil has been researched along with talinolol in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.70) | 18.7374 |
| 1990's | 4 (14.81) | 18.2507 |
| 2000's | 8 (29.63) | 29.6817 |
| 2010's | 14 (51.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thakker, DR; Troutman, MD | 1 |
| Collett, A; Hallifax, D; Tanianis-Hughes, J; Warhurst, G | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Creemer, CN; Dai, M; Davis, DC; Kyei-Baffour, K; Mohammad, H; Seleem, MN; Younis, W | 1 |
| Bloomer, WD; Chatelain, E; Ioset, JR; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Bloomer, WD; Kaiser, M; O'Shea, IP; Papadopoulou, MV; Rosenzweig, HS; Wilkinson, SR | 1 |
| Bassetto, M; Brancale, A; Ferla, S; Kandil, S; McGuigan, C; Pertusati, F; Westwell, AD | 1 |
| Abd Rabo Moustafa, MM; Abdelghany, TM; Eissa, IH; Elshafeey, A; Mayhoub, AS; Mohammad, H; Qassem, OA; Seleem, MN; Younis, W | 1 |
| Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS | 1 |
| Chreifi, G; Do, HT; Li, H; Poulos, TL; Silverman, RB; Wang, HY | 1 |
| Cini, E; De Santis, R; Giannini, G; Manera, F; Manetti, F; Milazzo, FM; Pace, S; Petricci, E; Stasi, MA; Tallarico, C; Vesci, L | 1 |
| Eslamimehr, S; Franzblau, SG; Kong, Y; Kurosu, M; Lemieux, MR; Mitachi, K; Park, F; Pressly, JD; Siricilla, S; Wang, Y; Yang, D | 1 |
| Weser, C | 1 |
| Ader, P; Baktir, G; Hanafy, A; Langguth, P; Okyar, A; Radschuweit, A; Spahn-Langguth, H; Terhaag, B | 1 |
| Döppenschmitt, S; Langguth, P; Regårdh, CG; Spahn-Langguth, H | 1 |
| Berndt, A; Gramatté, T; Kirch, W; Krappweis, J; Oertel, R; Schwarz, UI; von Richter, O | 1 |
| Gramatté, T; Oertel, R | 1 |
| Hanafy, A; Langguth, P; Spahn-Langguth, H | 1 |
| Bolger, MB; Langguth, P; Spahn-Langguth, H; Tubic, M; Wagner, D | 1 |
| Belli, S; Elsener, PM; Krämer, SD; Wunderli-Allenspach, H | 1 |
| Cuyckens, F; Hartshorn, MJ; Hill, A; Huisman, M; Leclercq, L; Mortishire-Smith, RJ | 1 |
| Furubayashi, T; Hidalgo, IJ; Katsumi, H; Sakane, T; Shingaki, T; Yamamoto, A; Yamashita, S | 1 |
| Kataoka, M; Masaoka, Y; Sakuma, S; Yamashita, S; Yokoyama, T | 1 |
1 trial(s) available for verapamil and talinolol
| Article | Year |
|---|---|
Unexpected effect of verapamil on oral bioavailability of the beta-blocker talinolol in humans.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Male; Mixed Function Oxygenases; Propanolamines; Reference Values; Verapamil | 1999 |
26 other study(ies) available for verapamil and talinolol
| Article | Year |
|---|---|
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2003 |
Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Caco-2 Cells; Cell Membrane Permeability; Humans; Intestinal Absorption; Mice; Mice, Knockout; Pharmacokinetics; Spectrometry, Mass, Electrospray Ionization | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Caco-2 Cells; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Humans; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Molecular Structure; Nitriles; Staphylococcus aureus; Structure-Activity Relationship; Vancomycin Resistance | 2015 |
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice; Mice, Inbred BALB C; Nitroreductases; Parasitic Sensitivity Tests; Prodrugs; Protein Structure, Tertiary; Protozoan Proteins; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Topics: Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Humans; Leishmania donovani; Mice; Mice, Inbred BALB C; Molecular Structure; Parasitic Sensitivity Tests; Piperazines; Rats; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma brucei rhodesiense; Trypanosoma cruzi | 2015 |
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer.
Topics: Anilides; Antineoplastic Agents; Benzamides; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Drug Resistance, Neoplasm; Humans; Male; Microsomes, Liver; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitriles; Permeability; Phenylthiohydantoin; Prostatic Neoplasms; Protein Conformation; Receptors, Androgen; Tosyl Compounds | 2016 |
Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Caenorhabditis elegans; Carbanilides; Drug Resistance, Bacterial; Methicillin-Resistant Staphylococcus aureus; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance | 2017 |
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles | 2017 |
Improvement of Cell Permeability of Human Neuronal Nitric Oxide Synthase Inhibitors Using Potent and Selective 2-Aminopyridine-Based Scaffolds with a Fluorobenzene Linker.
Topics: Aminopyridines; Animals; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Crystallography, X-Ray; Fluorobenzenes; Humans; Mice; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Structure-Activity Relationship; Swine; Theophylline; Verapamil | 2017 |
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Guanidine; Hedgehog Proteins; Humans; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; NIH 3T3 Cells; Structure-Activity Relationship; Thiourea | 2018 |
An antimycobacterial pleuromutilin analogue effective against dormant bacilli.
Topics: Administration, Oral; Animals; Antitubercular Agents; Area Under Curve; Biological Availability; Caco-2 Cells; Diterpenes; Female; Half-Life; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pleuromutilins; Polycyclic Compounds | 2018 |
[Treatment of angina pectoris with special reference to beta-blockers].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Anticoagulants; Calcium Channel Blockers; Diagnosis, Differential; Digitalis; Drug Therapy, Combination; Humans; Nifedipine; Nitrates; Nitroglycerin; Pentaerythritol Tetranitrate; Plants, Medicinal; Plants, Toxic; Propanolamines; Propranolol; Verapamil | 1982 |
P-glycoprotein transporters and the gastrointestinal tract: evaluation of the potential in vivo relevance of in vitro data employing talinolol as model compound.
Topics: Adrenergic beta-Antagonists; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Calcium Channel Blockers; Digestive System; Drug Interactions; Humans; In Vitro Techniques; Intestinal Absorption; Male; Propanolamines; Rats; Rats, Wistar; Verapamil | 1998 |
Radioligand-binding assay employing P-glycoprotein-overexpressing cells: testing drug affinities to the secretory intestinal multidrug transporter.
Topics: Adrenergic beta-Antagonists; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Caco-2 Cells; Calcium Channel Blockers; Fluorescent Dyes; Humans; Kinetics; Propanolamines; Radioligand Assay; Reproducibility of Results; Rhodamine 123; Rhodamines; Tritium; Verapamil; Vinblastine | 1998 |
Intestinal secretion of intravenous talinolol is inhibited by luminal R-verapamil.
Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Biological Availability; Calcium Channel Blockers; Drug Interactions; Humans; Infusions, Intravenous; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Propanolamines; Reference Values; Vasodilator Agents; Verapamil; Volunteers | 1999 |
Pretreatment with potent P-glycoprotein ligands may increase intestinal secretion in rats.
Topics: Adrenergic beta-Antagonists; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Colon; Duodenum; Jejunum; Ligands; Male; Propanolamines; Rats; Rats, Wistar; Stereoisomerism; Verapamil; Vinblastine | 2001 |
In silico modeling of non-linear drug absorption for the P-gp substrate talinolol and of consequences for the resulting pharmacodynamic effect.
Topics: Adrenergic beta-Antagonists; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bile; Calcium Channel Blockers; Computer Simulation; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Injections, Intravenous; Intestinal Absorption; Intestinal Mucosa; Liver Circulation; Microcomputers; Nonlinear Dynamics; Perfusion; Pharmaceutical Preparations; Propanolamines; Sterol O-Acyltransferase; Verapamil | 2006 |
Cholesterol-mediated activation of P-glycoprotein: distinct effects on basal and drug-induced ATPase activities.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Adenosine Triphosphatases; Adrenergic alpha-Agonists; alpha-Tocopherol; Animals; Anisotropy; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Line, Tumor; Cholesterol; Enzyme Induction; Excipients; Lipid Bilayers; Liposomes; Membranes, Artificial; Mice; Propanolamines; Verapamil; Vinblastine | 2009 |
IsoScore: automated localization of biotransformations by mass spectrometry using product ion scoring of virtual regioisomers.
Topics: Hydroxylation; Ions; Isomerism; Mass Spectrometry; Metabolomics; Propanolamines; Verapamil | 2009 |
Nasal delivery of P-gp substrates to the brain through the nose-brain pathway.
Topics: Administration, Intranasal; Adrenergic beta-Antagonists; Animals; ATP Binding Cassette Transporter, Subfamily B; Brain; Cyclosporine; Infusions, Intravenous; Male; Perfusion; Propanolamines; Rats; Rats, Sprague-Dawley; Verapamil | 2011 |
Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation.
Topics: Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Interactions; Erythromycin; Gene Expression; Glycerol; Humans; Intestinal Absorption; Loperamide; Models, Biological; Pharmaceutical Preparations; Propanolamines; Puromycin; Quinidine; Saquinavir; Solubility; Surface-Active Agents; Terfenadine; Verapamil; Vinblastine | 2011 |