Compounds > verapamil

verapamil and sdz psc 833

verapamil has been researched along with sdz psc 833 in 92 studies

Research

Studies (92)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's31 (33.70)18.2507
2000's43 (46.74)29.6817
2010's16 (17.39)24.3611
2020's2 (2.17)2.80

Authors

AuthorsStudies
Georges, E; L'Heureux, F; Liu, Z; Pouliot, JF; Prichard, RK1
Cvetkovic, M; Fromm, MF; Kim, RB; Leake, B; Wilkinson, GR1
Choo, EF; Imamura, H; Kim, RB; Leake, B; Wandel, C; Wilkinson, GR; Wood, AJ1
Achira, M; Crespi, CL; Ito, K; Kato, Y; Kawahara, I; Sugiyama, Y; Suzuki, H1
Belinsky, MG; Chen, ZS; Kruh, GD; Rea, PA; Zeng, H1
Chen, ZS; Kruh, GD; Kuwano, M; Lee, K; Raftogianis, RB; Walther, S; Zeng, H1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M1
Baltes, S; Fedrowitz, M; Gastens, AM; Kaever, V; Löscher, W; Potschka, H1
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Chow, LM; Jiang, T; Wan, SB; Wong, IL; Yan, CS; Zhang, PY; Zhang, XY1
Chan, KF; Chan, TH; Chow, LM; Kan, JW; Wong, IL; Yan, CS1
Chiba, P; Ecker, GF; Jabeen, I; Pleban, K; Rinner, U1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chai, S; Ke, CQ; Lin, G; Tang, C; To, KK; Wang, YZ; Yao, S; Ye, Y; Yin, C1
Chan, CF; Chan, KF; Chan, TH; Chong, TC; Chow, LMC; Chow, TS; Cui, J; Law, MC; Liu, Z; Wong, ILK; Zhu, X1
Didier, A; Loor, F; Pourtier-Manzanedo, A1
Boesch, D; Loor, F; Muller, K; Pourtier-Manzanedo, A1
Naito, M; Nishioka, Y; Ogura, T; Sone, S; Tsuruo, T; Yano, S1
Osann, K; Slater, L; Stupecky, M; Sweet, P; Wetzel, M1
Naito, M; Oh-Hara, T; Tsuge, H; Tsuruo, T; Watanabe, T1
Jachez, B; Loor, F1
Bischof, G; Cosentini, EP; Ellinger, A; Hamilton, G; Koperna, T; Riegler, M; Schweitzer, M; Teleky, B; Thalhammer, T; Zacherl, J1
Boesch, D; Loor, F1
Tsuruo, T1
Jachez, B; Loor, F; Nordmann, R1
Barrand, MA; Center, MS; Rhodes, T; Twentyman, PR1
Aracil, M; Barbacid, MM; Márquez, G; Mira, E; Quesada, AR1
Ahn, CH; Aszalos, A; Hrycyna, CA; Hwang, M; Licht, T; Pine, PS; Yin, JJ1
Didier, A; Loor, F; Wenger, J1
Drion, N; Lefauconnier, JM; Lemaire, M; Scherrmann, JM1
Davey, MW; Davey, RA; Hargrave, RM1
Aran, JM; Gottesman, MM; Licht, T; Pastan, I1
Chapey, C; Hu, YP; Robert, J1
Cayre, A; Finat-Duclos, F; Maublant, J; Moins, N; Verrelle, P2
Bertrán, J; García-López, J; Pétriz, J; Sánchez, J1
Haberl, I; Hamilton, G; Schaufler, K; Swatonek, H; Thalhammer, T; Theyer, G; Ulsperger, E; Wenzl, E1
Béliveau, R; Jetté, L; Murphy, GF1
den Boer, ML; Henze, G; Janka-Schaub, GE; Kazemier, KM; Pieters, R; Veerman, AJ1
Beck, JF; Boer, R; Buchholz, F; Gekeler, V; Niethammer, D; Sanders, KH; Ulrich, WR1
Gieseler, F; Gullis, E; Hasmann, M; Löser, R; Nüssler, V; Pelka-Fleisc, R; Stötzer, O; Wilmanns, W; Zwierzina, H1
Covey, DF; Luker, GD; Nilsson, KR; Piwnica-Worms, D1
Drewe, J; Droulle, A; Fricker, G; Gutmann, H; Miller, DS1
Friedmann, JM; Hauser, IA; Katsen, AD; Thévenod, F1
Estevez, MD; Schramm, U; Wolf, A1
Borst, P; Sarkadi, B; Smith, AJ; Szabo, K; Szakacs, G; van Helvoort, A; van Meer, G; Varadi, A; Welker, E1
Atadja, P; Cohen, D; Roninson, IB; Uchiyama, N; Watanabe, T1
Krishna, R; Mayer, LD1
Cho, CW; Henthorn, T; Liu, Y; Ng, KY; Yan, X1
Ehehalt, R; Fitscher, BA; Herrmann, T; Jochims, C; Pohl, J; Stremmel, W1
Blom-Roosemalen, MC; Breimer, DD; de Boer, AG; Nabulsi, L; van der Sandt, IC; Voorwinden, HH; Vos, CM1
Aszalos, A; Bocsi, J; Ladányi, A; Szende, B1
Cisternino, S; Dagenais, C; Rousselle, C; Scherrmann, JM1
Cohen, D; Uchiyama-Kokubu, N; Watanabe, T1
Borchard, G; de Boer, AG; Deryckere, K; Florea, BI; Junginger, HE; Kooiman, K; Schrier, SM; van der Sandt, IC1
Achira, M; Ito, K; Sugiyama, Y; Suzuki, H1
Droulle, L; Fricker, G; Fricker, S; Graeff, C; Miller, DS1
Kang, W; Weiss, M1
Crowe, A1
Dai, H; Luo, S; Peng, A; Yin, A1
Masquelier, M; Tatidis, L; Vitols, S1
Fuchs, J; Geerlings, H; Göhring, G; Teichmann, B; Warmann, S1
Belloc, F; Chollet, C; Goldman, JM; Lagarde, V; Mahon, FX; Melo, JV; Moreau-Gaudry, F; Reiffers, J1
Charman, WN; Johnson, BM; Porter, CJ1
Crowe, A; Wong, P1
Fedoruk, MN; Giménez-Bonafé, P; Guns, ES; Mayer, LD; Nelson, CC1
Cisternino, S; Debray, M; Rousselle, C; Scherrmann, JM1
Adachi, I; Kawakami, J; Kitazawa, H; Takagi, A; Yoshida, N1
Inaji, M; Kusuhara, H; Lee, YJ; Maeda, J; Nagai, Y; Nakao, R; Obayashi, S; Okauchi, T; Sugiyama, Y; Suhara, T; Suzuki, K1
Ades, S; Gould, CJ; Jones, GK; Levy, SB; Maxfield, LF1
Cole, B; Epel, D; Hamdoun, A; Thurber, RV1
Sikic, BI1
de Grouw, EP; de Witte, TJ; Jansen, JH; Raaijmakers, MH; Raymakers, RA; van der Reijden, BA1
Anglicheau, D; Beaune, P; Cassinat, B; Legendre, C; Marquet, P; Méria, P; Pallet, N; Rabant, M; Thervet, E1
Kurttila, T; Myllynen, P; Vähäkangas, K; Vaskivuo, L1
Bailey, B; Beck, WT; Bence, AK; Chu, S; Erickson, LC; Erickson, PA; Montrose, MH; Shen, F; Xue, X1
Ambudkar, SV; Barnett, D; Bates, SE; Finley, EM; Fojo, T; Oldham, RK; Robey, RW; Shukla, S1
Abrunhosa, AJ; Botelho, MF; Gomes, CM; Pauwels, EK1
Cardarelli, CO; Chen, KG; Gottesman, MM; Hearing, VJ; Lai, B; Leapman, RD; Valencia, JC; Vieira, WD; Zhang, G1
Borchardt, RT; Jin, JY; Mudra, DR1
Patel, KJ; Tannock, IF1
Döring, B; Geyer, J; Hambruch, N; Pfarrer, C; Tinneberg, HR; Waterkotte, B1
Akimoto, N; Ito, A; Kurihara, H; Ogura, T; Sato, T1
Fricker, G; Hülsermann, U; Lenhard, T; Martinez-Torres, F; Meyding-Lamadé, U1
Carpini, GD; Ghanem, CI; Luquita, MG; Mottino, AD; Novak, A; Rubio, MC; Ruiz, ML1
Ambadipudi, R; Georges, E; Laberge, RM1
Han, Y; Ma, J; Tang, S; Yang, Z; Zu, Y1
de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M1
de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M; Siissalo, S; van Dam, A1
de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M; van de Steeg, E1
Hammer, HS; Khalaf, S; Kroetz, DL; Mortensen, C; Nielsen, F; Poetz, O; Rodriguez-Antona, C; Stage, TB; Steffensen, V; Svenningsen, ÅF; Xiong, C1

Reviews

3 review(s) available for verapamil and sdz psc 833

ArticleYear
[MDR reversing drugs for clinical development].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:7

    Topics: Animals; Antineoplastic Agents; Cyclosporins; Doxorubicin; Drug Resistance; Drug Synergism; Humans; Leukemia P388; Mice; Quinolines; Verapamil

1994
Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 11, Issue:4

    Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cyclosporins; Drug Carriers; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glutathione; Humans; Verapamil

2000
Multidrug resistance and stem cells in acute myeloid leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jun-01, Volume: 12, Issue:11 Pt 1

    Topics: ADP-ribosyl Cyclase 1; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bone Marrow Cells; Cyclosporins; Drug Resistance, Multiple; Gene Expression Profiling; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Mitoxantrone; Reverse Transcriptase Polymerase Chain Reaction; Verapamil

2006

Trials

1 trial(s) available for verapamil and sdz psc 833

ArticleYear
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
    Biochemical pharmacology, 2008, Mar-15, Volume: 75, Issue:6

    Topics: Adenosine Triphosphatases; Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Factors; Biological Transport; Cell Line; Cell Line, Tumor; Cyclosporins; Depsipeptides; Fluorescent Dyes; Fluorouracil; Humans; Insecta; Multidrug Resistance-Associated Proteins; Neoplasms; Paclitaxel; Prazosin; Quinolines; Rhodamine 123; Verapamil; Vinblastine

2008

Other Studies

88 other study(ies) available for verapamil and sdz psc 833

ArticleYear
Reversal of P-glycoprotein-associated multidrug resistance by ivermectin.
    Biochemical pharmacology, 1997, Jan-10, Volume: 53, Issue:1

    Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Drug Resistance, Multiple; Humans; Ivermectin; Vinblastine

1997
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.
    Drug metabolism and disposition: the biological fate of chemicals, 1999, Volume: 27, Issue:8

    Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Carrier Proteins; Genes, MDR; HeLa Cells; Histamine H1 Antagonists; Humans; LLC-PK1 Cells; Mice; Rats; Swine; Terfenadine; Tissue Distribution; Transfection; Vaccinia virus

1999
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Caco-2 Cells; Dibenzocycloheptenes; HIV Protease Inhibitors; Humans; Inhibitory Concentration 50; Male; Mice; Quinolines; Testis

2000
Selective inhibition of human cytochrome P450 3A4 by N-[2(R)-hydroxy-1(S)-indanyl]-5-[2(S)-(1, 1-dimethylethylaminocarbonyl)-4-[(furo[2, 3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethy lpentanamide and P-glycoprotein by valspodar in
    Drug metabolism and disposition: the biological fate of chemicals, 2000, Volume: 28, Issue:10

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cyclosporins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Digoxin; Dose-Response Relationship, Drug; Humans; Hydroxylation; Indans; Microsomes; Midazolam; Mixed Function Oxygenases; Piperazines; Recombinant Proteins; Transfection

2000
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.
    Cancer research, 2001, Oct-01, Volume: 61, Issue:19

    Topics: 3T3 Cells; Animals; ATP-Binding Cassette Transporters; Biological Transport; Drug Resistance, Multiple; Folic Acid; Humans; Leucovorin; Methotrexate; Mice; Multidrug Resistance-Associated Proteins; Osmolar Concentration; Polyglutamic Acid; Tritium

2001
Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.
    Cancer research, 2002, Jun-01, Volume: 62, Issue:11

    Topics: Animals; Antimetabolites, Antineoplastic; Baculoviridae; Carrier Proteins; Cell Line; Folate Receptors, GPI-Anchored; Folic Acid; Insecta; Liposomes; LLC-PK1 Cells; Methotrexate; Multidrug Resistance-Associated Proteins; Osmosis; Polyglutamic Acid; Receptors, Cell Surface; Swine; Transfection

2002
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
    Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity

2004
Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein.
    Neuropharmacology, 2007, Volume: 52, Issue:2

    Topics: Analysis of Variance; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Carbamazepine; Cell Line; Cyclosporine; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gene Expression; Humans; Levetiracetam; Mice; Phenytoin; Piracetam; Transfection

2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Design and syntheses of permethyl ningalin B analogues: potent multidrug resistance (MDR) reversal agents of cancer cells.
    Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Heterocyclic Compounds, 3-Ring; Humans; Paclitaxel; Pyrroles; Stereoisomerism; Structure-Activity Relationship; Vincristine

2010
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.
    Journal of medicinal chemistry, 2012, Mar-08, Volume: 55, Issue:5

    Topics: Adenosine Triphosphatases; Amines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzylamines; Cell Line, Tumor; Dimerization; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flavones; Flavonoids; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Paclitaxel; Polyethylene Glycols; Solubility; Structure-Activity Relationship

2012
Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein.
    Journal of medicinal chemistry, 2012, Apr-12, Volume: 55, Issue:7

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzophenones; Binding Sites; Cell Line, Tumor; Crystallography, X-Ray; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ligands; Models, Molecular; Molecular Conformation; Propafenone; Quantitative Structure-Activity Relationship; Serotonin Plasma Membrane Transport Proteins; Structure-Activity Relationship

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Polyoxypregnane steroids from the stems of Marsdenia tenacissima.
    Journal of natural products, 2014, Sep-26, Volume: 77, Issue:9

    Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Erlotinib Hydrochloride; Gefitinib; Glycosides; Humans; Marsdenia; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pregnanes; Quinazolines

2014
Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2).
    Journal of medicinal chemistry, 2021, 10-14, Volume: 64, Issue:19

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonoids; HEK293 Cells; Humans; Mitoxantrone; Neoplasm Proteins; Structure-Activity Relationship; Substrate Specificity

2021
Expression of P-glycoprotein on normal lymphocytes: enhancement of the doxorubicin-sensitivity of concanavalin A-responding mouse spleen cells by P-glycoprotein blockers.
    Oncology research, 1992, Volume: 4, Issue:11-12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD8 Antigens; Concanavalin A; Cyclosporins; Doxorubicin; Drug Resistance; Drug Synergism; Female; Lymphocyte Activation; Lymphocyte Depletion; Lymphocytes; Membrane Glycoproteins; Mice; Peptides, Cyclic; Spleen; T-Lymphocyte Subsets; Verapamil

1992
Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative.
    Experimental cell research, 1991, Volume: 196, Issue:1

    Topics: Amiodarone; Animals; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Flow Cytometry; Leukemia, Experimental; Leukemia, Myeloid; Microscopy, Fluorescence; Quinacrine; Quinidine; Tumor Cells, Cultured; Verapamil

1991
Cyclosporin A enhances susceptibility of multi-drug resistant human cancer cells to anti-P-glycoprotein antibody-dependent cytotoxicity of monocytes, but not of lymphocytes.
    Japanese journal of cancer research : Gann, 1994, Volume: 85, Issue:2

    Topics: Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Carrier Proteins; Cyclosporine; Cyclosporins; Drug Resistance; Female; Humans; KB Cells; Killer Cells, Natural; Leukemia, Myeloid; Lymphocytes; Membrane Glycoproteins; Monocytes; Neoplasm Proteins; Ovarian Neoplasms; Protein Binding; Tacrolimus; Tumor Cells, Cultured; Verapamil

1994
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.
    Leukemia research, 1995, Volume: 19, Issue:8

    Topics: Animals; Cell Survival; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Glycerol; Leukemia L1210; Leukemia P388; Mice; Survival Analysis; Tumor Cells, Cultured; Verapamil

1995
Comparative study on reversal efficacy of SDZ PSC 833, cyclosporin A and verapamil on multidrug resistance in vitro and in vivo.
    Acta oncologica (Stockholm, Sweden), 1995, Volume: 34, Issue:2

    Topics: Animals; Antineoplastic Agents; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Humans; Leukemia, Myeloid; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Tumor Cells, Cultured; Verapamil; Vincristine

1995
Atypical multi-drug resistance (MDR): low sensitivity of a P-glycoprotein-expressing human T lymphoblastoid MDR cell line to classical P-glycoprotein-directed resistance-modulating agents.
    Anti-cancer drugs, 1993, Volume: 4, Issue:6

    Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance; Flow Cytometry; Humans; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Peptides, Cyclic; Tumor Cells, Cultured; Verapamil

1993
Inhibition of P-glycoprotein-mediated vinblastine transport across HCT-8 intestinal carcinoma monolayers by verapamil, cyclosporine A and SDZ PSC 833 in dependence on extracellular pH.
    Cancer chemotherapy and pharmacology, 1994, Volume: 34, Issue:2

    Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Cyclosporine; Cyclosporins; Depression, Chemical; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Hydrogen-Ion Concentration; Ileal Neoplasms; Ileocecal Valve; Membrane Glycoproteins; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vinblastine

1994
Extent and persistence of P-glycoprotein inhibition in multidrug-resistant P388 cells after exposure to resistance-modifying agents.
    Anti-cancer drugs, 1994, Volume: 5, Issue:2

    Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance; Extracellular Space; Leukemia P388; Membrane Glycoproteins; Mice; Molecular Sequence Data; Peptides, Cyclic; Verapamil

1994
Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446.
    Journal of the National Cancer Institute, 1993, Mar-17, Volume: 85, Issue:6

    Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Cyclosporins; Drug Resistance; Leukemia P388; Mice; Paclitaxel; Peptides, Cyclic; Tumor Cells, Cultured; Verapamil

1993
Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein.
    European journal of cancer (Oxford, England : 1990), 1993, Volume: 29A, Issue:3

    Topics: Carcinoma, Non-Small-Cell Lung; Cyclosporine; Cyclosporins; Daunorubicin; Humans; Lung Neoplasms; Membrane Proteins; Molecular Weight; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vincristine

1993
Chemosensitization and drug accumulation assays as complementary methods for the screening of multidrug resistance reversal agents.
    Cancer letters, 1996, Jan-19, Volume: 99, Issue:1

    Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colonic Neoplasms; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; Leukemia P388; Mice; Rhodamine 123; Rhodamines; Verapamil

1996
Effect of combination of suboptimal concentrations of P-glycoprotein blockers on the proliferation of MDR1 gene expressing cells.
    International journal of cancer, 1996, Jan-26, Volume: 65, Issue:3

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Division; Cell Membrane; Cyclosporins; Glycerol; Humans; Leukemia; Transfection; Tumor Cells, Cultured; Verapamil

1996
Decreased uptake of cyclosporin A by P-glycoprotein (Pgp) expressing CEM leukemic cells and restoration of normal retention by Pgp blockers.
    Anti-cancer drugs, 1995, Volume: 6, Issue:5

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Flow Cytometry; Humans; Immunosuppressive Agents; Leukemia, Monocytic, Acute; Leukemia, T-Cell; Mice; Peptides, Cyclic; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine

1995
Role of P-glycoprotein in the blood-brain transport of colchicine and vinblastine.
    Journal of neurochemistry, 1996, Volume: 67, Issue:4

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Colchicine; Cyclosporins; Male; Organ Specificity; Radioisotope Dilution Technique; Rats; Rats, Sprague-Dawley; Sucrose; Tissue Distribution; Tritium; Verapamil; Vinblastine

1996
Comparison of drug accumulation in P-glycoprotein-expressing and MRP-expressing human leukaemia cells.
    Leukemia research, 1996, Volume: 20, Issue:8

    Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Buthionine Sulfoximine; Calcium Channel Blockers; Cyclosporins; Daunorubicin; Humans; Idarubicin; Leukemia, T-Cell; Multidrug Resistance-Associated Proteins; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil

1996
Complete restoration of glucocerebrosidase deficiency in Gaucher fibroblasts using a bicistronic MDR retrovirus and a new selection strategy.
    Human gene therapy, 1996, Nov-10, Volume: 7, Issue:17

    Topics: Animals; Anthracenes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Blotting, Western; Cells, Cultured; Colchicine; Cyclosporins; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fibroblasts; Gaucher Disease; Gene Expression Regulation; Genetic Therapy; Genetic Vectors; Glucosylceramidase; Humans; Mice; Mutagenesis, Insertional; Retroviridae; Transfection; Verapamil

1996
Relationship between the inhibition of azidopine binding to P-glycoprotein by MDR modulators and their efficiency in restoring doxorubicin intracellular accumulation.
    Cancer letters, 1996, Dec-03, Volume: 109, Issue:1-2

    Topics: Affinity Labels; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cyclosporine; Cyclosporins; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Humans; Mice; Nicardipine; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil

1996
Comparison between technetium-99m-sestamibi and hydrogen-3-daunomycin myocardial cellular retention in vitro.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1997, Volume: 38, Issue:11

    Topics: Animals; Animals, Newborn; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporins; Daunorubicin; Drug Resistance, Neoplasm; Genes, MDR; Heart; In Vitro Techniques; Myocardium; Piperidines; Radionuclide Imaging; Rats; Rats, Wistar; Technetium Tc 99m Sestamibi; Triazines; Tritium; Verapamil

1997
Comparative effect of verapamil, cyclosporin A and SDZ PSC 833 on rhodamine 123 transport and cell cycle in vinblastine-resistant Chinese hamster ovary cells overexpressing P-glycoprotein.
    Anti-cancer drugs, 1997, Volume: 8, Issue:9

    Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Cycle; Cell Line; CHO Cells; Cricetinae; Cyclosporine; Cyclosporins; DNA; Drug Resistance, Neoplasm; Flow Cytometry; Immunosuppressive Agents; Rhodamine 123; Rhodamines; Verapamil; Vinblastine

1997
P-glycoprotein-mediated multidrug resistance is modulated by pretreatment with chemosensitizers in HCT-8 carcinoma cells in vitro.
    International journal of oncology, 1998, Volume: 12, Issue:5

    Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Ileal Neoplasms; Ileocecal Valve; Kinetics; Phosphorylation; Rhodamine 123; Rhodamines; Tamoxifen; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Verapamil; Vinblastine

1998
Drug binding to P-glycoprotein is inhibited in normal tissues following SDZ-PSC 833 treatment.
    International journal of cancer, 1998, May-29, Volume: 76, Issue:5

    Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Brain; Calcium Channel Blockers; Capillaries; Cyclosporine; Cyclosporins; Drug Interactions; Fluorescent Dyes; Injections, Subcutaneous; Iodine Radioisotopes; Kidney; Liver; Male; Microvilli; Photoaffinity Labels; Prazosin; Rats; Rats, Sprague-Dawley; Rhodamine 123; Rhodamines; Verapamil; Vinblastine

1998
The modulating effect of PSC 833, cyclosporin A, verapamil and genistein on in vitro cytotoxicity and intracellular content of daunorubicin in childhood acute lymphoblastic leukemia.
    Leukemia, 1998, Volume: 12, Issue:6

    Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Survival; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance, Neoplasm; Genistein; Humans; In Vitro Techniques; Multidrug Resistance-Associated Proteins; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Verapamil

1998
Rhodamine 123 efflux modulation in the presence of low or high serum from CD56+ hematopoietic cells or CD34+ leukemic blasts by B9309-068, a newly designed pyridine derivative.
    Cancer letters, 1998, Jul-17, Volume: 129, Issue:2

    Topics: Acridines; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Blood Proteins; Calcium Channel Blockers; CD56 Antigen; Cyclosporins; Dihydropyridines; Dose-Response Relationship, Drug; Flow Cytometry; Fluorescent Dyes; Gene Expression; Humans; Isoquinolines; Leukemia, Myeloid, Acute; Leukocytes, Mononuclear; Morpholines; Multidrug Resistance-Associated Proteins; Pyrimidines; Rhodamine 123; Rhodamines; Tetrahydroisoquinolines; Verapamil

1998
In vitro efficacy of known P-glycoprotein modulators compared to droloxifene E and Z: studies on a human T-cell leukemia cell line and their resistant variants.
    Leukemia & lymphoma, 1998, Volume: 31, Issue:5-6

    Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Division; Cyclosporins; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Leukemia, T-Cell; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Tamoxifen; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Verapamil

1998
Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol.
    The Journal of biological chemistry, 1999, Mar-12, Volume: 274, Issue:11

    Topics: 3T3 Cells; Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane; Cholesterol; Cyclosporins; Dehydroepiandrosterone; Dibenzocycloheptenes; Drug Resistance, Multiple; Esterification; Humans; Isoquinolines; Mice; Progesterone; Quinolines; Stereoisomerism; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil

1999
Comparative 99mTc-sestamibi and 3H-daunomycin uptake in human carcinoma cells: relation to the MDR phenotype and effects of reversing agents.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1999, Volume: 40, Issue:4

    Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cyclosporins; Daunorubicin; Drug Resistance, Multiple; Humans; Piperidines; Radiopharmaceuticals; Reverse Transcriptase Polymerase Chain Reaction; Technetium Tc 99m Sestamibi; Triazines; Tritium; Tumor Cells, Cultured; Verapamil

1999
Epithelial transport of anthelmintic ivermectin in a novel model of isolated proximal kidney tubules.
    Pharmaceutical research, 1999, Volume: 16, Issue:10

    Topics: Animals; Anthelmintics; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Chemokines, CC; Cyclosporins; Cytokines; Epithelium; In Vitro Techniques; Ivermectin; Kidney Tubules, Proximal; Killifishes; Macrophage Inflammatory Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Verapamil

1999
Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappaB activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis.
    The Journal of biological chemistry, 2000, Jan-21, Volume: 275, Issue:3

    Topics: Animals; Annexin A5; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cadmium; Cadmium Chloride; Calcium Channel Blockers; Cell Line; Cyclosporine; Cyclosporins; Enzyme Inhibitors; Fluoresceins; Kidney Tubules, Proximal; Kinetics; Necrosis; NF-kappa B; Oxidative Stress; Rats; Rats, Inbred WKY; Reactive Oxygen Species; Time Factors; Up-Regulation; Verapamil

2000
Effect of PSC 833, verapamil and amiodarone on adriamycin toxicity in cultured rat cardiomyocytes.
    Toxicology in vitro : an international journal published in association with BIBRA, 2000, Volume: 14, Issue:1

    Topics: Actins; Amiodarone; Animals; Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cells, Cultured; Creatine Kinase; Cyclosporins; Doxorubicin; Heart; Image Processing, Computer-Assisted; Immunohistochemistry; Isoenzymes; Myocardial Contraction; Myocardium; Rats; Rats, Wistar; Verapamil

2000
MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping.
    The Journal of biological chemistry, 2000, Aug-04, Volume: 275, Issue:31

    Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Cell Polarity; Cells, Cultured; Cyclosporine; Cyclosporins; Cytotoxins; Daunorubicin; Digoxin; Epithelial Cells; Humans; Ivermectin; Kidney; Paclitaxel; Pharmaceutical Preparations; Phosphatidylcholines; Recombinant Proteins; Spodoptera; Swine; Verapamil; Vinblastine

2000
Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein.
    International journal of oncology, 2000, Volume: 17, Issue:3

    Topics: Adenosine Triphosphatases; Amino Acid Substitution; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Carcinoma, Squamous Cell; Colchicine; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Paclitaxel; Point Mutation; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured; Verapamil; Vinblastine

2000
Carrier-mediated uptake of rhodamine 123: implications on its use for MDR research.
    Biochemical and biophysical research communications, 2000, Dec-09, Volume: 279, Issue:1

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Drug Resistance, Multiple; Humans; Rhodamine 123; Tumor Cells, Cultured; Verapamil

2000
Functional and histochemical analysis of MDR3 P-glycoprotein in a tetracycline-controlled gene expression system.
    European journal of medical research, 2000, Dec-29, Volume: 5, Issue:12

    Topics: Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Blotting, Western; Calcium Channel Blockers; Choline; Cloning, Molecular; Cyclosporins; DNA, Complementary; Doxycycline; Drug Resistance, Multiple; Gene Expression Regulation; HeLa Cells; Hepatocytes; Humans; Immunohistochemistry; Luciferases; Phosphatidylcholines; Rabbits; Taurocholic Acid; Tritium; Verapamil

2000
Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood--brain barrier.
    AIDS (London, England), 2001, Mar-09, Volume: 15, Issue:4

    Topics: Animals; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Blood-Brain Barrier; Caco-2 Cells; Carbamates; Cattle; Cell Line, Transformed; Cells, Cultured; Coculture Techniques; Cyclosporins; Dibenzocycloheptenes; Endothelium, Vascular; Furans; HIV Protease Inhibitors; Humans; Indinavir; LLC-PK1 Cells; Multidrug Resistance-Associated Proteins; Probenecid; Quinolines; Rats; Rats, Wistar; Ritonavir; Sulfonamides; Swine; Verapamil

2001
Induction of apoptosis in MDR1 expressing cells by daunorubicin with combinations of suboptimal concentrations of P-glycoprotein modulators.
    Cancer letters, 2001, Jun-26, Volume: 167, Issue:2

    Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cyclosporins; Daunorubicin; Drug Combinations; Drug Interactions; G2 Phase; Glycerol; Mice; Verapamil

2001
Screening of multidrug-resistance sensitive drugs by in situ brain perfusion in P-glycoprotein-deficient mice.
    Pharmaceutical research, 2001, Volume: 18, Issue:2

    Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Colchicine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Isoquinolines; Male; Mice; Perfusion; Tetrahydroisoquinolines; Time Factors; Verapamil; Vinblastine

2001
Intracellular levels of two cyclosporin derivatives valspodar (PSC 833) and cyclosporin a closely associated with multidrug resistance-modulating activity in sublines of human colorectal adenocarcinoma HCT-15.
    Japanese journal of cancer research : Gann, 2001, Volume: 92, Issue:10

    Topics: Adenocarcinoma; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Division; Colorectal Neoplasms; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Inhibitory Concentration 50; Intracellular Fluid; Rhodamine 123; Tumor Cells, Cultured; Verapamil

2001
Evidence of P-glycoprotein mediated apical to basolateral transport of flunisolide in human broncho-tracheal epithelial cells (Calu-3).
    British journal of pharmacology, 2001, Volume: 134, Issue:7

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bronchi; Cell Line; Cell Polarity; Cell Survival; Cyclosporins; Deoxyglucose; Dibenzocycloheptenes; Epithelial Cells; Fluocinolone Acetonide; Humans; Immunoblotting; Mass Spectrometry; Microscopy, Confocal; Quinolines; Sodium Azide; Temperature; Time Factors; Trachea; Verapamil

2001
Comparative studies to determine the selective inhibitors for P-glycoprotein and cytochrome P4503A4.
    AAPS pharmSci, 1999, Volume: 1, Issue:4

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cyclosporins; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Humans; Indans; Intestine, Small; Ketoconazole; Liver; Microsomes; Midazolam; Mixed Function Oxygenases; Piperazines; Verapamil; Vinblastine

1999
Xenobiotic efflux pumps in isolated fish brain capillaries.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2002, Volume: 282, Issue:1

    Topics: 4-Chloro-7-nitrobenzofurazan; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Boron Compounds; Brain; Calcium Channel Blockers; Capillaries; Cyclosporine; Cyclosporins; Dogfish; Enzyme Inhibitors; Fluorescent Dyes; Fundulidae; In Vitro Techniques; Indicators and Reagents; Leukotriene C4; Membrane Transport Proteins; Microscopy, Confocal; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Potassium Cyanide; Verapamil; Xenobiotics

2002
Influence of P-glycoprotein modulators on cardiac uptake, metabolism, and effects of idarubicin.
    Pharmaceutical research, 2001, Volume: 18, Issue:11

    Topics: Algorithms; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Daunorubicin; Heart; Idarubicin; In Vitro Techniques; Male; Myocardium; Rats; Rats, Sprague-Dawley; Stroke Volume; Verapamil

2001
The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel.
    European journal of pharmacology, 2002, Apr-05, Volume: 440, Issue:1

    Topics: Analgesics, Opioid; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buthionine Sulfoximine; Caco-2 Cells; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Genistein; Glutathione; Humans; Indomethacin; Morphine; Paclitaxel; Probenecid; Progesterone; Time Factors; Verapamil

2002
[Reversal of multidrug-resistance in human leukemia cell line K562/A02 by a cyclosporin D analogue PSC 833].
    Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi, 2002, Volume: 23, Issue:1

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Humans; K562 Cells; RNA, Messenger; Verapamil

2002
Elevated uptake of low density lipoprotein by drug resistant human leukemic cell lines.
    Biochemical pharmacology, 2002, Jun-15, Volume: 63, Issue:12

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Line; Cholesterol; Cyclosporins; Drug Resistance, Neoplasm; Humans; Hydroxymethylglutaryl CoA Reductases; Leukemia; Lipoproteins, LDL; Membrane Fluidity; Receptors, LDL; Sterols; Tumor Cells, Cultured; Verapamil

2002
MDR1 modulators improve the chemotherapy response of human hepatoblastoma to doxorubicin in vitro.
    Journal of pediatric surgery, 2002, Volume: 37, Issue:11

    Topics: Acridines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression; Genes, MDR; Hepatoblastoma; Humans; Inhibitory Concentration 50; Isoquinolines; Liver Neoplasms; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil

2002
MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models.
    Blood, 2003, Mar-15, Volume: 101, Issue:6

    Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzamides; Cell Death; Cell Division; Colony-Forming Units Assay; Cyclosporins; Doxorubicin; Drug Resistance, Neoplasm; Flow Cytometry; Gene Expression; Genes, MDR; Humans; Imatinib Mesylate; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Phosphotyrosine; Piperazines; Pyrimidines; Transfection; Tumor Cells, Cultured; Verapamil

2003
Application of compartmental modeling to an examination of in vitro intestinal permeability data: assessing the impact of tissue uptake, P-glycoprotein, and CYP3A.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:9

    Topics: Animals; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporins; Cytochrome P-450 CYP3A; In Vitro Techniques; Intestinal Absorption; Jejunum; Ketoconazole; Male; Midazolam; Models, Biological; Oxidoreductases, N-Demethylating; Permeability; Rats; Rats, Sprague-Dawley; Time Factors; Verapamil

2003
Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport.
    Toxicology and applied pharmacology, 2003, Nov-15, Volume: 193, Issue:1

    Topics: Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Calcium Channels; Cyclosporine; Cyclosporins; Diphenoxylate; Drug Interactions; Humans; Loperamide; Narcotics; Probenecid; Sulfinpyrazone; Verapamil

2003
P-glycoprotein increases the efflux of the androgen dihydrotestosterone and reduces androgen responsive gene activity in prostate tumor cells.
    The Prostate, 2004, Apr-01, Volume: 59, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Northern; Blotting, Western; Cyclosporins; Dihydrotestosterone; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Male; Neoplasms, Hormone-Dependent; Precipitin Tests; Prostatic Neoplasms; Receptors, Androgen; RNA, Neoplasm; Verapamil

2004
In situ transport of vinblastine and selected P-glycoprotein substrates: implications for drug-drug interactions at the mouse blood-brain barrier.
    Pharmaceutical research, 2004, Volume: 21, Issue:8

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Colchicine; Cyclosporins; Dexamethasone; Drug Interactions; Male; Mice; Mice, Inbred Strains; Morphine; Progesterone; Quinidine; Verapamil; Vinblastine

2004
Inhibition of P-glycoprotein-mediated transport by extracts of and monoterpenoids contained in Zanthoxyli fructus.
    Toxicology and applied pharmacology, 2005, Dec-01, Volume: 209, Issue:2

    Topics: Acyclic Monoterpenes; Aldehydes; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporins; Digoxin; Drug Interactions; Humans; Inhibitory Concentration 50; LLC-PK1 Cells; Monoterpenes; Plant Extracts; Swine; Transfection; Verapamil; Zanthoxylum

2005
In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil.
    The Journal of pharmacology and experimental therapeutics, 2006, Volume: 316, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Carbon Radioisotopes; Chromatography, High Pressure Liquid; Cyclosporins; Macaca mulatta; Male; Positron-Emission Tomography; Substrate Specificity; Verapamil

2006
Selection of non-P-glycoprotein mediated high-level etoposide resistant cell lines by adriamycin with P-gp inhibitors.
    International journal of oncology, 2006, Volume: 28, Issue:3

    Topics: Animals; Antigens, Neoplasm; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclosporins; Daunorubicin; DNA Topoisomerases, Type II; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Verapamil

2006
The sea urchin embryo as a model for studying efflux transporters: roles and energy cost.
    Marine environmental research, 2006, Volume: 62 Suppl

    Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cyclosporins; Cytotoxins; Embryo, Nonmammalian; Energy Metabolism; Etoposide; Fluoresceins; Membrane Transport Proteins; Models, Animal; Propionates; Quinolines; Sea Urchins; Verapamil; Vinblastine

2006
ABCB1 modulation does not circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal cells in acute myelogenous leukemia.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Jun-01, Volume: 12, Issue:11 Pt 1

    Topics: Adolescent; ADP-ribosyl Cyclase 1; Adult; Aged; Antigens, CD34; Antigens, Differentiation; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Bone Marrow Cells; Cyclosporins; Drug Resistance, Multiple; Female; Flow Cytometry; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Mitoxantrone; Oncogene Proteins, Fusion; Reverse Transcriptase Polymerase Chain Reaction; Verapamil

2006
Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction.
    Kidney international, 2006, Volume: 70, Issue:6

    Topics: Acetanilides; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Fluorescent Dyes; Humans; Immunosuppressive Agents; Kidney; Pyrroles; Quinine; Quinolines; Rhodamines; Sirolimus; Verapamil

2006
DNA damage caused by benzo(a)pyrene in MCF-7 cells is increased by verapamil, probenecid and PSC833.
    Toxicology letters, 2007, Feb-28, Volume: 169, Issue:1

    Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Benzo(a)pyrene; Calcium Channel Blockers; Carcinogens; Cell Line, Tumor; Cell Survival; Cyclosporins; DNA Adducts; DNA Damage; Drug Synergism; Female; Humans; Probenecid; Renal Agents; Tetrazolium Salts; Thiazoles; Tumor Suppressor Protein p53; Verapamil

2007
Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 324, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Cyclosporine; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Verapamil

2008
P-glycoprotein versus MRP1 on transport kinetics of cationic lipophilic substrates: a comparative study using [99mTc]sestamibi and [99mTc]tetrofosmin.
    Cancer biotherapy & radiopharmaceuticals, 2009, Volume: 24, Issue:2

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line, Tumor; Cyclosporins; Drug Resistance, Neoplasm; Humans; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Organophosphorus Compounds; Organotechnetium Compounds; Radionuclide Imaging; Radiopharmaceuticals; ROC Curve; Small Cell Lung Carcinoma; Technetium Tc 99m Sestamibi; Tumor Cells, Cultured; Verapamil

2009
Influence of melanosome dynamics on melanoma drug sensitivity.
    Journal of the National Cancer Institute, 2009, Sep-16, Volume: 101, Issue:18

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Line, Tumor; Cisplatin; Cyclosporins; Doxorubicin; Drug Resistance, Neoplasm; Fluorescent Antibody Technique, Indirect; Humans; Melanoma; Melanoma, Experimental; Melanosomes; Mice; Microscopy, Confocal; Microscopy, Electron; Skin Neoplasms; Verapamil; Vinblastine

2009
Absorption barriers in the rat intestinal mucosa: 2. Application of physiologically based mathematical models to quantify mechanisms of drug permeation and metabolism.
    Journal of pharmaceutical sciences, 2010, Volume: 99, Issue:2

    Topics: Acridines; Adrenergic beta-Antagonists; Algorithms; Animals; Atenolol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Computer Simulation; Cyclosporins; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Intestinal Absorption; Intestinal Mucosa; Ketoconazole; Models, Statistical; Pharmaceutical Preparations; Rats; Tetrahydroisoquinolines; Verapamil

2010
The influence of P-glycoprotein expression and its inhibitors on the distribution of doxorubicin in breast tumors.
    BMC cancer, 2009, Oct-06, Volume: 9

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Vessels; Breast Neoplasms; Cell Line, Tumor; Cyclosporins; Disease Models, Animal; Doxorubicin; Drug Therapy, Combination; Female; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Verapamil

2009
P-glycoprotein is functionally expressed in the placenta-derived bovine caruncular epithelial cell line 1 (BCEC-1).
    Placenta, 2011, Volume: 32, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cattle; Cell Line; Cyclosporins; Digoxin; Female; Mice; Neoplasm Proteins; Placenta; Pregnancy; Verapamil

2011
Identification and characterization of ABCB1-mediated and non-apoptotic sebum secretion in differentiated hamster sebocytes.
    Biochimica et biophysica acta, 2011, Volume: 1811, Issue:12

    Topics: Acne Vulgaris; Adenosine Triphosphate; Animals; Antibodies; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Cell Differentiation; Cricetinae; Cyclosporins; Dermatitis, Seborrheic; Epithelial Cells; Gene Expression; Humans; Insulin; Male; Phosphatidylserines; Rhodamines; Sebaceous Glands; Sebum; Triglycerides; Verapamil

2011
A simple method to quickly and simultaneously purify and enrich intact rat brain microcapillaries and endothelial and glial cells for ex vivo studies and cell culture.
    Brain research, 2013, Jun-26, Volume: 1519

    Topics: Adjuvants, Pharmaceutic; Animals; Animals, Newborn; Brain; Calcium Channel Blockers; Cell Culture Techniques; Cell Separation; Cells, Cultured; Coculture Techniques; Cyclosporins; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Indicators and Reagents; Neuroglia; Probenecid; Rats; Rats, Sprague-Dawley; Time Factors; Verapamil

2013
Acetaminophen inhibits intestinal p-glycoprotein transport activity.
    Journal of pharmaceutical sciences, 2013, Volume: 102, Issue:10

    Topics: Acetaminophen; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Cell Line, Tumor; Cyclosporins; Digoxin; Enterocytes; Hep G2 Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Permeability; Rats; Rats, Wistar; Rhodamine 123; Verapamil

2013
P-glycoprotein mediates the collateral sensitivity of multidrug resistant cells to steroid hormones.
    Biochemical and biophysical research communications, 2014, May-16, Volume: 447, Issue:4

    Topics: Adenosine Triphosphatases; Animals; Antimycin A; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; Cricetulus; Cyclosporins; Desoxycorticosterone; Drug Resistance, Multiple; Drug Synergism; Electron Transport Chain Complex Proteins; Gene Knockdown Techniques; Progesterone; Reactive Oxygen Species; RNA, Small Interfering; Rotenone; Verapamil

2014
Effects of P-glycoprotein and its inhibitors on apoptosis in K562 cells.
    Molecules (Basel, Switzerland), 2014, Aug-25, Volume: 19, Issue:9

    Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caspase 3; Cell Cycle Checkpoints; Cyclosporins; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Humans; K562 Cells; Verapamil

2014
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.
    Toxicology in vitro : an international journal published in association with BIBRA, 2015, Volume: 29, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; In Vitro Techniques; Intestinal Mucosa; Isoquinolines; Ketoconazole; Male; Quinazolines; Quinidine; Rats, Wistar; Rhodamine 123; Verapamil

2015
The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:5

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Cytochrome P-450 CYP3A; Drug Interactions; Ileum; Intestinal Absorption; Jejunum; Ketoconazole; Male; Pharmaceutical Preparations; Quinidine; Rats; Rats, Wistar; Valine; Verapamil

2016
The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo.
    Toxicology in vitro : an international journal published in association with BIBRA, 2017, Volume: 40

    Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colon; Cyclosporins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Ileum; In Vitro Techniques; Isoquinolines; Jejunum; Ketoconazole; Male; Middle Aged; Quinazolines; Quinidine; Verapamil

2017
P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer.
    Clinical pharmacology and therapeutics, 2020, Volume: 108, Issue:3

    Topics: Antineoplastic Agents, Phytogenic; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neurons; Paclitaxel; Peripheral Nervous System Diseases; Retrospective Studies; Risk Assessment; Risk Factors; Simvastatin; Verapamil

2020