verapamil has been researched along with rifampin in 80 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (5.00) | 18.7374 |
| 1990's | 4 (5.00) | 18.2507 |
| 2000's | 15 (18.75) | 29.6817 |
| 2010's | 46 (57.50) | 24.3611 |
| 2020's | 11 (13.75) | 2.80 |
| Authors | Studies |
|---|---|
| Fardel, O; Guillouzo, A; Lecureur, V; Loyer, P | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Collett, A; Hallifax, D; Tanianis-Hughes, J; Warhurst, G | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Bucar, F; Gröblacher, B; Kunert, O | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Barton, P; Ismair, M; Jupp, R; Riley, RJ; Soars, MG | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Chibale, K; Kumar, M; Naran, K; Pavadai, E; Ruminski, PG; Singh, K; Warner, DF | 1 |
| Alam, MZ; Bruhn, DF; Feng, L; Hurdle, JG; Lee, RB; Lee, RE; Maddox, MM; Narula, G; Sandhaus, S; Simmons, CJ; Sun, D; Tse-Dinh, YC; Tsutsumi, LS; Wu, X | 1 |
| Dixit, PP; Thore, SN | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS | 1 |
| Abdelghany, TM; Elkabbany, AH; Ghiaty, A; Hagras, M; Hegazy, YA; Mayhoub, AS; Mohammad, H; Seleem, MN | 1 |
| Cleghorn, LAT; Davis, S; Epemolu, O; Ferguson, L; Green, SR; Guijarro, L; Hipskind, P; Huggett, M; Korkegian, A; Kumar, A; Lopez Moure, A; Masquelin, T; Odingo, J; Parish, T; Ray, PC; Read, KD; Riley, J; Rullas, J; Scullion, P; Shishikura, Y; Smith, A; Turner, P; Wescott, H; Wilson, C; Wyatt, PG; Zuccotto, F | 1 |
| Eslamimehr, S; Franzblau, SG; Kong, Y; Kurosu, M; Lemieux, MR; Mitachi, K; Park, F; Pressly, JD; Siricilla, S; Wang, Y; Yang, D | 1 |
| Abutaleb, NS; Elsebaei, MM; Gowher, H; Mayhoub, AS; Michie, AR; Mohammad, H; Moustafa, MM; Norvil, AB; Samir, A; Samy, H; Seleem, MN | 1 |
| Abutaleb, NS; Alhashimi, M; Kassab, AE; Mayhoub, AS; Mohamed, KO; Seleem, MN; Shahin, IG; Taher, AT | 1 |
| Almeida da Silva, PE; da Silva, MV; de Andrade, VP; de Oliveira, M; Halicki, PCB; Mateus, M; Ramos, DF; Rodrigues, V; Vianna, JS; Zanatta, N | 1 |
| Bora, A; Deka, B; Devi, MV; Dihingia, A; Pahari, P; Sarma, S; Sen, T; Singh, AK; Suri, M | 1 |
| Ang, CW; Avery, VM; Bernhardt, PV; Blaskovich, MAT; Bolisetti, R; Cooper, MA; Francisco, AF; Franzblau, SG; Hinton, AO; Jackson, CJ; Kelly, JM; Lee, BM; Sykes, ML; Tan, L; Wang, Y; West, NP | 1 |
| Baciewicz, AM; Bekemeyer, WB; Self, TH | 1 |
| Barbarash, RA; Batenhorst, RL; Bauman, JL; Fischer, JH; Kondos, GT | 1 |
| Böhm, R; Mooy, J; Rahn, KH; vd Vet, A | 1 |
| Launchbury, AP | 1 |
| Beck, WT; Schuetz, EG; Schuetz, JD | 1 |
| Busse, D; Eichelbaum, M; Fromm, MF; Kroemer, HK | 1 |
| Lennernäs, H; Sandström, R | 1 |
| Pollack, GM; Zong, J | 1 |
| Hankø, E; Hansen, TW; Tommarello, S; Watchko, JF | 1 |
| Gerloff, T; Mrozikiewicz, PM; Oselin, K; Pähkla, R; Roots, I | 1 |
| Bartoli, F; Candussio, L; Decorti, G; Drigo, I; Giraldi, T; Granzotto, M; Rosati, A | 1 |
| Collett, A; Tanianis-Hughes, J; Warhurst, G | 1 |
| Bansal, T; Kaul, CL; Panchagnula, R; Varma, MV | 1 |
| Srinivas, NR | 1 |
| Guo, CA; Han, N; Liu, J; Shen, F; Shi, Y; Yan, Z; Zhang, Z | 1 |
| Allen, J; Bebawy, M; Kota, BP; Roufogalis, BD; Tran, VH | 1 |
| Rao, N | 1 |
| Gey van Pittius, NC; Grobbelaar, M; Hernandez-Pando, R; Jimenez, A; Leon, R; Louw, GE; McEvoy, CR; Murray, M; van Helden, PD; Victor, TC; Warren, RM | 1 |
| Abuznait, AH; Burk, D; Cain, C; Ingram, D; Kaddoumi, A | 1 |
| Abuznait, AH; Kaddoumi, A; Patrick, SG | 1 |
| Be, X; Berry, L; Chen, A; Huang, L; Janosky, B; Lin, MH; Roberts, J | 1 |
| Amaral, L; Baptista, P; Couto, I; Machado, D; Perdigão, J; Portugal, I; Rodrigues, L; Veigas, B; Viveiros, M | 1 |
| Caritis, SN; Dorko, K; Ellis, EC; Gramignoli, R; Hansel, M; Hines, RN; Mattison, DR; Sharma, S; Strom, SC; Tahan, V; Venkataramanan, R | 1 |
| Baciewicz, AM; Chrisman, CR; Finch, CK; Self, TH | 1 |
| Barter, Z; Jamei, M; Neuhoff, S; Rostami-Hodjegan, A; Turner, DB; Yeo, KR | 1 |
| Almeida, DV; Ammerman, NC; Bishai, WR; Gupta, S; Maiga, MC; Tyagi, S | 1 |
| Kaur, P; Li, W; Sharma, M | 1 |
| Caleffi-Ferracioli, KR; Canezin, PH; Cardoso, RF; Demitto, Fde O; do Amaral, RC; Lopes, MA; Maltempe, FG; Scodro, RB; Siqueira, VL | 1 |
| Benet, LZ; Chen, X; Okochi, H; Zheng, Y | 1 |
| Ban, JJ; Chu, K; Chung, JY; Im, W; Kim, M; Lee, ST | 1 |
| Abate, G; Campbell, M; Chibale, K; Eickhoff, CS; Hamzabegovic, F; Hoft, DF; Kumar, M; Ruminiski, PG; Selimovic, A; Singh, K | 1 |
| Baluom, M; Brealey, C; Craven, K; Gillen, M; Grossbard, EB; Lau, D; Mant, T; Martin, P; Millson, D; Oliver, S; Sweeny, D | 1 |
| Britton, WJ; Chan, HK; Chan, JG; Pang, A; Parumasivam, T; Quan, DH; Triccas, JA | 1 |
| Amaral, RC; Caleffi-Ferracioli, KR; Canezin, PH; Cardoso, RF; Demitto, FO; Leite, CQ; Maltempe, FG; Nakamura, CV; Scodro, RB; Siqueira, VL | 1 |
| Jung, JA; Parvez, MM; Shin, HJ; Shin, JG | 1 |
| Barros, ILE; Caleffi-Ferracioli, KR; Canezin, PH; Cardoso, RF; Pavan, FR; Scodro, RBL; Siqueira, VLD | 1 |
| Caleffi-Ferracioli, KR; Canezin, PH; Cardoso, RF; de Souza, JV; Ld Siqueira, V; Murase, LS; Pavan, FR; Scodro, RB | 1 |
| Li, G; Liu, B; Liu, Q; Meng, X; Yang, C | 1 |
| Dickinson, GL; Hall, SD; Kulanthaivel, P; Morse, BL; Posada, MM; Turner, PK | 1 |
| Bader, K; Ebner, T; Fromm, MF; Giessmann, T; Hauel, E; Hohl, K; Ishiguro, N; Jambrecina, A; Mikus, G; Müller, F; Schmidt-Gerets, S; Sharma, A; Stopfer, P; Taub, ME; Wiebe, ST | 1 |
| Chen, Z; de Rooij, LJ; Groeneweg, S; Meima, ME; Peeters, RP; van der Sman, ASE; Visser, WE | 1 |
| Deutsch, B; Fromm, MF; Gessner, A; Hohl, K; Keller, S; Müller, F; Schmidt-Gerets, S; Schuler-Metz, A; Stopfer, P | 1 |
| Adams, KN; Dei, S; Edelstein, PH; Fowler, E; Lake, MA; Nie, F; Ramakrishnan, L; Sherman, DR; Spring, DR; Teodori, E; Troll, M; Verma, AK | 1 |
| Aslan, G; Ersoy, L; Özgür, D; Tezcan Ülger, S; Ülger, M | 1 |
| Adeel, A; Ahmad, A; Ahmad, I; Aslam, H; Mushtaq, F; Raza, SM; Saleem, S | 1 |
4 review(s) available for verapamil and rifampin
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Some recently introduced drugs.
Topics: Amidines; Anti-Bacterial Agents; Antidepressive Agents; Antihypertensive Agents; Bronchodilator Agents; Chemical Phenomena; Chemistry; Clopamide; Drug Therapy; Ethacrynic Acid; Expectorants; Glycolates; Humans; Indoles; Neuromuscular Nondepolarizing Agents; Penicillin G; Pentazocine; Prednisolone; Prenylamine; Propanidid; Quinolines; Rifampin; Sympatholytics; Verapamil | 1970 |
Update on rifampin, rifabutin, and rifapentine drug interactions.
Topics: Anti-Arrhythmia Agents; Antibiotics, Antitubercular; Anticholesteremic Agents; Antifungal Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Contraceptives, Oral; Cytochrome P-450 Enzyme System; Digoxin; Drug Interactions; HIV Protease Inhibitors; Humans; Itraconazole; Rifabutin; Rifampin; Simvastatin; Verapamil | 2013 |
3 trial(s) available for verapamil and rifampin
| Article | Year |
|---|---|
Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies.
Topics: Adult; Aminopyridines; Cross-Over Studies; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Double-Blind Method; Drug Interactions; Humans; Ketoconazole; Male; Microsomes, Liver; Morpholines; Oxazines; Pyridines; Pyrimidines; Rifampin; Verapamil; Young Adult | 2016 |
Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.
Topics: Area Under Curve; Cimetidine; Drug Interactions; Humans; Male; Probenecid; Rifampin; Verapamil | 2020 |
N
Topics: Biomarkers; Cimetidine; Creatinine; Drug Interactions; Humans; Membrane Transport Proteins; Probenecid; Rifampin; Verapamil | 2023 |
73 other study(ies) available for verapamil and rifampin
| Article | Year |
|---|---|
Rifampicin enhances anti-cancer drug accumulation and activity in multidrug-resistant cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Humans; Rats; Rifampin; Structure-Activity Relationship; Vinblastine | 1995 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Caco-2 Cells; Cell Membrane Permeability; Humans; Intestinal Absorption; Mice; Mice, Knockout; Pharmacokinetics; Spectrometry, Mass, Electrospray Ionization | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Compounds of Alpinia katsumadai as potential efflux inhibitors in Mycobacterium smegmatis.
Topics: Alpinia; Antibiotics, Antitubercular; Antitubercular Agents; Diarylheptanoids; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium smegmatis; Plant Extracts; Seeds | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.
Topics: Cell Line; Drug Discovery; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c.
Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Binding Sites; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Mycobacterium tuberculosis; Rifampin; Structure-Activity Relationship; Verapamil | 2014 |
Synthesis, structure-activity relationship studies, and antibacterial evaluation of 4-chromanones and chalcones, as well as olympicin A and derivatives.
Topics: Animals; Anti-Bacterial Agents; Chalcones; Chemistry Techniques, Synthetic; Chlorocebus aethiops; Chromones; DNA Gyrase; DNA Topoisomerase IV; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Phloroglucinol; Structure-Activity Relationship; Topoisomerase II Inhibitors; Vero Cells | 2014 |
Hybrid triazoles: Design and synthesis as potential dual inhibitor of growth and efflux inhibition in tuberculosis.
Topics: Antitubercular Agents; Cells, Cultured; Chemistry Techniques, Synthetic; Drug Design; Drug Evaluation, Preclinical; Drug Synergism; Extensively Drug-Resistant Tuberculosis; Humans; Macrophages; Microbial Sensitivity Tests; Mycobacterium smegmatis; Mycobacterium tuberculosis; Triazoles | 2016 |
The antitubercular activity of various nitro(triazole/imidazole)-based compounds.
Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles | 2017 |
Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Biological Availability; Cell Line; Chemical Phenomena; Cricetinae; Humans; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Oxadiazoles; Rats; Solubility; Structure-Activity Relationship; Thiazoles | 2018 |
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Cytochromes c; Mice; Morpholines; Mycobacterium tuberculosis; Oxidoreductases; Structure-Activity Relationship; Thiophenes; Vero Cells | 2018 |
An antimycobacterial pleuromutilin analogue effective against dormant bacilli.
Topics: Administration, Oral; Animals; Antitubercular Agents; Area Under Curve; Biological Availability; Caco-2 Cells; Diterpenes; Female; Half-Life; Humans; Inhibitory Concentration 50; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pleuromutilins; Polycyclic Compounds | 2018 |
Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity.
Topics: Animals; Anti-Bacterial Agents; Carbon-13 Magnetic Resonance Spectroscopy; Cell Line; Chromatography, Liquid; Enzyme Inhibitors; Lipids; Macrophages; Mass Spectrometry; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Proton Magnetic Resonance Spectroscopy; Pyrophosphatases; Structure-Activity Relationship; Thiazoles | 2019 |
Evaluation of N-phenyl-2-aminothiazoles for treatment of multi-drug resistant and intracellular Staphylococcus aureus infections.
Topics: Animals; Anti-Bacterial Agents; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Humans; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Microsomes, Liver; Molecular Structure; Staphylococcal Infections; Structure-Activity Relationship; Thiazoles | 2020 |
2,2,2-trifluoro-1-(1,4,5,6-tetrahydropyridin-3-yl)ethanone derivative as efflux pump inhibitor in Mycobacterium tuberculosis.
Topics: Acetophenones; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Membrane Transport Proteins; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Structure-Activity Relationship | 2021 |
Potentiating the intracellular killing of Staphylococcus aureus by dihydroquinazoline analogues as NorA efflux pump inhibitor.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Cell Survival; Dose-Response Relationship, Drug; Humans; Microbial Sensitivity Tests; Molecular Structure; Multidrug Resistance-Associated Proteins; Quinazolines; Staphylococcus aureus; Structure-Activity Relationship; THP-1 Cells | 2022 |
Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
Topics: Animals; Chagas Disease; Disease Models, Animal; Mice; Mycobacterium tuberculosis; Nitroimidazoles; Nitroreductases; Trypanosoma cruzi; Tuberculosis | 2022 |
Update on rifampin drug interactions.
Topics: Adrenergic beta-Antagonists; Cyclosporins; Digoxin; Drug Interactions; Humans; Ketoconazole; Phenytoin; Rifampin; Theophylline; Verapamil | 1987 |
Near-total reduction in verapamil bioavailability by rifampin. Electrocardiographic correlates.
Topics: Administration, Oral; Adult; Biological Availability; Drug Interactions; Electrocardiography; Female; Heart; Humans; Injections, Intravenous; Male; Rifampin; Verapamil | 1988 |
Reduction of bioavailability of verapamil by rifampin.
Topics: Biological Availability; Drug Interactions; Humans; Rifampin; Verapamil | 1985 |
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Cell Line; Clotrimazole; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Midazolam; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phenobarbital; Phenytoin; Polymerase Chain Reaction; Rifampin; Tumor Cells, Cultured; Verapamil | 1996 |
Differential induction of prehepatic and hepatic metabolism of verapamil by rifampin.
Topics: Administration, Oral; Adult; Biological Availability; Digestive System; Drug Interactions; Enzyme Induction; Humans; Injections, Intravenous; Liver; Male; Rifampin; Stereoisomerism; Verapamil | 1996 |
Repeated oral rifampicin decreases the jejunal permeability of R/S-verapamil in rats.
Topics: Algorithms; Animals; Antibiotics, Antitubercular; Calcium Channel Blockers; Glucose; Intestinal Absorption; Jejunum; Male; Perfusion; Rats; Rats, Sprague-Dawley; Rifampin; Stereoisomerism; Verapamil | 1999 |
Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin.
Topics: Animals; Antibiotics, Antitubercular; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Dose-Response Relationship, Drug; Drug Interactions; Mice; Perfusion; Quinidine; Rifampin; Verapamil | 2003 |
Administration of drugs known to inhibit P-glycoprotein increases brain bilirubin and alters the regional distribution of bilirubin in rat brain.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bilirubin; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Ceftriaxone; Enzyme Inhibitors; Erythromycin; Female; Humans; Male; Propranolol; Rats; Rats, Sprague-Dawley; Rifampin; Verapamil | 2003 |
MDR1 polymorphisms G2677T in exon 21 and C3435T in exon 26 fail to affect rhodamine 123 efflux in peripheral blood lymphocytes.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; CD4 Antigens; CD56 Antigen; Exons; Genes, MDR; Humans; In Vitro Techniques; Killer Cells, Natural; Lymphocytes; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Rhodamine 123; Rifampin; T-Lymphocytes, Helper-Inducer; Verapamil | 2003 |
Rifampicin and verapamil induce the expression of P-glycoprotein in vivo in Ehrlich ascites tumor cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Calcium Channel Blockers; Carcinoma, Ehrlich Tumor; Doxorubicin; Drug Resistance, Multiple; Enzyme Inhibitors; Female; Mice; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; Verapamil | 2004 |
Rapid induction of P-glycoprotein expression by high permeability compounds in colonic cells in vitro: a possible source of transporter mediated drug interactions?
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cells, Cultured; Colon; Drug Interactions; Gene Expression; Humans; Propranolol; Rifampin; Verapamil | 2004 |
Co-treatment with grapefruit juice inhibits while chronic administration activates intestinal P-glycoprotein-mediated drug efflux.
Topics: Algorithms; Animals; Antineoplastic Agents, Phytogenic; Antitubercular Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Citrus paradisi; Dose-Response Relationship, Drug; Food-Drug Interactions; HIV Protease Inhibitors; Ileum; In Vitro Techniques; Indinavir; Intestinal Absorption; Male; Paclitaxel; Permeability; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Rifampin; Verapamil | 2005 |
Efflux transporter-mediated interactions with atorvastatin--interesting findings with multiple substrates: istradefylline, verapamil, and rifampicin.
Topics: Anticholesteremic Agents; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Heptanoic Acids; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Purines; Pyrroles; Rifampin; Verapamil | 2009 |
Effects of p-glycoprotein on steroid-induced osteonecrosis of the femoral head.
Topics: Adipogenesis; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Count; Enzyme Inhibitors; Femur Head Necrosis; Glucocorticoids; Male; Osteoblasts; Osteoclasts; Rats; Rats, Sprague-Dawley; Rifampin; Verapamil | 2010 |
Characterization of PXR mediated P-glycoprotein regulation in intestinal LS174T cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Membrane; Drug Interactions; Humans; Intestinal Mucosa; Intestines; Pregnane X Receptor; Receptors, Steroid; Rhodamine 123; Rifampin; RNA, Messenger; Verapamil | 2010 |
Re: Efflux transporter-mediated interactions with atorvastatin--interesting findings with multiple substrates: istradefylline, verapamil, and rifampicin.
Topics: Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Organic Anion Transporters; Purines; Pyrroles; Research Design; Rifampin; Verapamil | 2011 |
Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacterial Proteins; Calcium Channel Blockers; Cell Culture Techniques; Disease Models, Animal; DNA-Directed RNA Polymerases; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Ofloxacin; Reserpine; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; Tuberculosis, Multidrug-Resistant; Verapamil | 2011 |
Up-regulation of P-glycoprotein reduces intracellular accumulation of beta amyloid: investigation of P-glycoprotein as a novel therapeutic target for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cell Line; Central Nervous System Agents; Dexamethasone; Estradiol; Humans; Pentylenetetrazole; Phloroglucinol; Rifampin; Staining and Labeling; Terpenes; Up-Regulation; Verapamil | 2011 |
Exposure of LS-180 cells to drugs of diverse physicochemical and therapeutic properties up-regulates P-glycoprotein expression and activity.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Caffeine; Cell Line, Tumor; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Gene Expression; Humans; Pentylenetetrazole; Pharmaceutical Preparations; Phloroglucinol; Rhodamine 123; Rifampin; Stimulation, Chemical; Terpenes; Up-Regulation; Verapamil | 2011 |
Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds.
Topics: Animals; Bosentan; Capillary Permeability; Chromatography, Liquid; Cyclosporine; Dogs; Fluorobenzenes; Hepatocytes; Madin Darby Canine Kidney Cells; Male; Metabolic Clearance Rate; Pyrimidines; Quinidine; Rats; Rats, Sprague-Dawley; Rifampin; Rosuvastatin Calcium; Sulfonamides; Tandem Mass Spectrometry; Verapamil; Xenobiotics | 2012 |
Contribution of efflux to the emergence of isoniazid and multidrug resistance in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Biological Transport, Active; Carrier Proteins; Catalase; Chlorpromazine; DNA-Directed RNA Polymerases; Drug Resistance, Multiple, Bacterial; Gene Expression; Humans; Isoniazid; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Rifampin; Thioridazine; Tuberculosis, Multidrug-Resistant; Verapamil | 2012 |
Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes.
Topics: 17 alpha-Hydroxyprogesterone Caproate; Adult; Age Factors; Aged; Biological Transport; Cells, Cultured; Cold Temperature; Cyclosporine; Female; Gestational Age; Hepatocytes; Humans; Hydroxyprogesterones; Kinetics; Male; Membrane Transport Proteins; Middle Aged; Multidrug Resistance-Associated Protein 2; Rifampin; RNA, Messenger; Taurocholic Acid; Verapamil; Young Adult | 2013 |
Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin.
Topics: Adjuvants, Anesthesia; Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B; Computer Simulation; Digoxin; Drug Interactions; Enzyme Inhibitors; Humans; Midazolam; Models, Biological; Permeability; Rifampin; Verapamil | 2013 |
Acceleration of tuberculosis treatment by adjunctive therapy with verapamil as an efflux inhibitor.
Topics: Adjuvants, Pharmaceutic; Animals; Antitubercular Agents; Calcium Channel Blockers; Drug Therapy, Combination; Female; Mice; Mice, Inbred C3H; Mycobacterium tuberculosis; Recurrence; Rifampin; Time Factors; Tuberculosis, Pulmonary; Verapamil | 2013 |
The DrrAB efflux system of Streptomyces peucetius is a multidrug transporter of broad substrate specificity.
Topics: Amino Acid Sequence; ATP-Binding Cassette Transporters; Bacterial Proteins; Biological Transport; Daunorubicin; Doxorubicin; Kinetics; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Mutation; Rifampin; Sequence Homology, Amino Acid; Streptomyces; Vanadates; Verapamil; Vinblastine | 2014 |
In vitro activity of rifampicin and verapamil combination in multidrug-resistant mycobacterium tuberculosis.
Topics: Antibiotics, Antitubercular; Calcium Channel Blockers; Drug Resistance, Multiple, Bacterial; Ethidium; Humans; Mycobacterium tuberculosis; Rifampin; Tuberculosis, Multidrug-Resistant; Verapamil | 2015 |
pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion.
Topics: Adrenergic beta-Antagonists; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Diffusion; Dogs; Drug Interactions; Humans; Hydrogen-Ion Concentration; Leprostatic Agents; Madin Darby Canine Kidney Cells; Male; Permeability; Propranolol; Rats; Rats, Sprague-Dawley; Rifampin; Stereoisomerism; Verapamil | 2015 |
Multidrug resistance protein 1 reduces the aggregation of mutant huntingtin in neuronal cells derived from the Huntington's disease R6/2 model.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cells, Cultured; Disease Models, Animal; Female; Humans; Huntingtin Protein; Huntington Disease; Immunohistochemistry; Male; Mice, Transgenic; Motor Activity; Mutation; Nerve Tissue Proteins; Neurons; Nucleic Acid Synthesis Inhibitors; Protein Aggregation, Pathological; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; RNA Interference; Vasodilator Agents; Verapamil | 2015 |
New Verapamil Analogs Inhibit Intracellular Mycobacteria without Affecting the Functions of Mycobacterium-Specific T Cells.
Topics: Animals; Autophagy; Humans; Isoniazid; Leukocytes, Mononuclear; Macrophage Activation; Macrophages; Mice, Transgenic; Mycobacterium bovis; Mycobacterium tuberculosis; Rifampin; T-Lymphocytes; Verapamil | 2015 |
In Vitro Evaluation of Inhalable Verapamil-Rifapentine Particles for Tuberculosis Therapy.
Topics: Adenocarcinoma; Administration, Inhalation; Aerosols; Anti-Arrhythmia Agents; Antibiotics, Antitubercular; Cell Survival; Chemistry, Pharmaceutical; Humans; In Vitro Techniques; Lung Neoplasms; Microbial Sensitivity Tests; Monocytes; Mycobacterium tuberculosis; Particle Size; Rifampin; Tuberculosis; Verapamil | 2016 |
Morphological changes and differentially expressed efflux pump genes in Mycobacterium tuberculosis exposed to a rifampicin and verapamil combination.
Topics: Antibiotics, Antitubercular; Bacterial Proteins; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gene Expression Regulation, Bacterial; Membrane Transport Proteins; Microbial Viability; Microscopy, Electron, Scanning; Mycobacterium tuberculosis; Rifampin; Time Factors; Transcription, Genetic; Verapamil | 2016 |
Evaluation of
Topics: Aminosalicylic Acid; Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cimetidine; Drug Interactions; HEK293 Cells; Humans; Ibuprofen; Liver-Specific Organic Anion Transporter 1; Naproxen; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 2; Probenecid; Proton Pump Inhibitors; Quinidine; Rifampin; Verapamil | 2017 |
Intramacrophage Mycobacterium tuberculosis efflux pump gene regulation after rifampicin and verapamil exposure.
Topics: Antibiotics, Antitubercular; Bacterial Outer Membrane Proteins; Down-Regulation; Gene Expression Regulation, Bacterial; Humans; Macrophages; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Polymerase Chain Reaction; Rifampin; THP-1 Cells; Verapamil | 2018 |
Modulatory effects of verapamil in rifampicin activity against Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Brazil; Catalase; DNA-Directed RNA Polymerases; Drug Resistance, Multiple, Bacterial; Drug Synergism; Drug Therapy, Combination; Gene Expression Regulation, Bacterial; Genotype; Humans; Membrane Transport Proteins; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Oxidoreductases; Rifampin; Time Factors; Tuberculosis, Multidrug-Resistant; Verapamil | 2019 |
Effect of P-glycoprotein regulation on cadmium exhaustion from Crassostrea gigas.
Topics: Animals; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cadmium; Crassostrea; Inactivation, Metabolic; Metallothionein; Rifampin; Seawater; Tissue Distribution; Verapamil; Water Pollutants, Chemical | 2019 |
Predicting Clinical Effects of CYP3A4 Modulators on Abemaciclib and Active Metabolites Exposure Using Physiologically Based Pharmacokinetic Modeling.
Topics: Administration, Oral; Adult; Aged; Alkynes; Aminopyridines; Area Under Curve; Benzimidazoles; Benzoxazines; Bosentan; Clarithromycin; Computer Simulation; Cyclin-Dependent Kinases; Cyclopropanes; Cytochrome P-450 CYP3A Inducers; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Female; Healthy Volunteers; Humans; Itraconazole; Ketoconazole; Male; Middle Aged; Modafinil; Models, Biological; Rifampin; Verapamil | 2020 |
Thyroid Hormone Transporters in a Human Placental Cell Model.
Topics: Amino Acid Transport Systems, Neutral; Animals; Chlorocebus aethiops; Female; Humans; Monocarboxylic Acid Transporters; Peptides; Placenta; Pregnancy; Rifampin; RNA, Messenger; RNA, Small Interfering; Symporters; Thyroid Hormones; Thyroxine; Triiodothyronine; Tryptophan; Verapamil | 2022 |
The human proton pump inhibitors inhibit
Topics: Antitubercular Agents; Bacterial Proteins; Drug Tolerance; Humans; Macrophages; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Proton Pump Inhibitors; Rifampin; Tuberculosis; Verapamil | 2023 |
[Investigation of Efflux Pump Genes in Resistant Mycobacterium tuberculosis Complex Clinical Isolates Exposed to First Line Antituberculosis Drugs and Verapamil Combination].
Topics: Antitubercular Agents; Bacterial Proteins; DNA, Complementary; Humans; Isoniazid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Rifampin; Tuberculosis; Tuberculosis, Multidrug-Resistant; Verapamil | 2023 |
Antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure.
Topics: Amikacin; Antitubercular Agents; Humans; Isoniazid; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Mycobacterium tuberculosis; Pyrazinamide; Rifampin; Tuberculosis, Multidrug-Resistant; Verapamil | 2023 |