verapamil has been researched along with reserpine in 113 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (43.36) | 18.7374 |
| 1990's | 16 (14.16) | 18.2507 |
| 2000's | 22 (19.47) | 29.6817 |
| 2010's | 25 (22.12) | 24.3611 |
| 2020's | 1 (0.88) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Chan, T; Chang, C; Croy, V; Hall, AM; Kuczek, T; Ruff, D | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 2 |
| Borchardt, RT; Horie, K; Tang, F | 3 |
| Pajeva, IK; Wiese, M | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Globisch, C; Kassack, MU; Klinkhammer, W; Müller, H; Pajeva, IK; Wiese, M | 1 |
| Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Andotra, SS; Khan, IA; Koul, S; Kumar, A; Qazi, GN; Raja, AF; Reddy, MV; Sangwan, PL; Thota, N | 1 |
| Müller, H; Pick, A; Wiese, M | 1 |
| Kalia, NP; Khan, IA; Koul, JL; Koul, S; Kumar, A; Qazi, GN; Reddy, MV; Sangwan, PL; Thota, N | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Kalia, NP; Khan, IA; Koul, JL; Koul, S; Kumar, A; Reddy, MV; Sangwan, PL; Thota, N | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Christensen, SB; Holler, JG; Mølgaard, P; Olsen, CE; Slotved, HC | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Gupta, S; Jachak, SM; Kumari, N; Nandanwar, H; Pahwa, S; Roy, SK | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Choi, SH; Kazantsev, AG; Khanfar, MA; Quinti, L; Silverman, RB; Wang, H | 1 |
| Creemer, CN; Dai, M; Davis, DC; Kyei-Baffour, K; Mohammad, H; Seleem, MN; Younis, W | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Abdelghany, TM; Bayoumi, SA; Disouky, AM; El-Morsy, A; Elshafeey, A; Mancy, AS; Mayhoub, AS; Mohammad, H; Seleem, MA; Seleem, MN | 1 |
| Ghiaty, A; Hagras, M; Hegazy, YA; Mandour, MS; Mayhoub, AS; Mohammad, H; Seleem, MN | 1 |
| Bharate, SB; Joshi, P; Vishwakarma, RA | 1 |
| Chibale, K; Egan, TJ; Hunter, R; Joshi, MC; Ndove, J; Nsumiwa, S; Okombo, J; Taylor, D; Wiesner, L | 1 |
| Nayler, WG; Poole-Wilson, PA; Yepez, CE | 1 |
| James, TN; Urthaler, F | 1 |
| Akera, T; Bennett, JL; Brody, TM; Chubb, JM | 1 |
| Bongrani, S; Ferrari, R | 1 |
| Görlitz, BD; Schümann, HJ; Wagner, J | 1 |
| Schümann, HJ; Wagner, J | 1 |
| García, AG; Horga, JF; Pascual, R; Sánchez-García, P | 1 |
| Baig, H; Braunwald, E; Pagani, M; Vatner, SF | 1 |
| Denkl, P; Haas, Th | 1 |
| Lefebvre, PJ; Luyckx, AS | 1 |
| Henderson, GB | 1 |
| Crosland, RD | 1 |
| Chang, PL; Dixon, WR | 1 |
| Garcia, J; Schmidlin, O; Schwartz, JB | 1 |
| Allen, CN; Gray, TJ; Harpur, ES; Hirst, BH; Simmons, NL | 1 |
| Colucci, WS; Powers, RE | 1 |
| Safa, AR; Spearman, T; Van Dyke, K; Ye, ZG | 1 |
| Beck, WT; Cirtain, MC; Felsted, RL; Glover, CJ; Safa, AR | 1 |
| Klohs, WD; Steinkampf, RW | 1 |
| Catanzaro, OL; Savino, EA | 1 |
| Ho, ST; Lee, SH; Yen, MH | 1 |
| Kobayashi, M; Ohizumi, Y; Yasumoto, T | 1 |
| Miller, RC; Schoeffter, P | 1 |
| Fukuda, H; Ishida, Y; Iwamoto, T; Kanaya, J; Maeshiba, Y; Moritoki, H | 1 |
| Dmitrevskaya, TV; Neyfakh, AA; Serpinskaya, AS | 1 |
| Das, PK; Mishra, SK; Sanyal, AK | 1 |
| Carlsson, L; Graefe, KH; Trendelenburg, U | 1 |
| Mogami, H; Sakamoto, Y; Shimizu, K; Ushio, Y; Yoshida, T | 1 |
| Giles, TD; Given, MB; Sander, GE | 1 |
| Frances, H; Renwart, N; Simon, P | 1 |
| Chaudhry, A; Vohra, MM | 2 |
| Dorigo, P; Maragno, I | 1 |
| Duncan, R; Krzanowski, J; Lockey, R; Martin, DF; Polson, J; Sakamoto, Y; Szentivanyi, A | 1 |
| Nast, HP; Philipp, T | 1 |
| Fratz, R; Greeff, K; Wagner, J | 2 |
| Couraud, F; Fayet, G; Lissitzky, S; Miranda, F | 1 |
| Degenring, FH | 1 |
| Heeg, E; Reuter, N | 1 |
| Morris, R | 2 |
| Kolassa, N; Pfleger, K; Volkmer, I | 1 |
| Schollmeyer, P | 1 |
| Heinrich, F; Schultis, K | 1 |
| Carson, V; Lowe, TE; McInnes, I; Nayler, WG; Price, JM; Race, D; Swann, JB | 1 |
| Aramendía, P; Kaumann, AJ | 1 |
| Büchner, M; Effert, S; Grosse-Brockhoff, F | 1 |
| Kajiwara, A; Ohizumi, Y; Yasumoto, T | 1 |
| Ajzen, H; de Albuquerque, EM; Draibe, SA; Gelman, A; Reynaldo Stella, S | 1 |
| Delgado, C; Diez, J; Tamargo, J | 1 |
| Alegría, E; Arcas, R; Barba, J; Llorens, R; Malpartida, F; Martín Trenor, A | 1 |
| Bender, F | 1 |
| al-Bekairi, AM; al-Rajhi, AM; Tariq, M | 1 |
| Hurt, CM; Pelleg, A; Xu, J | 1 |
| Phung-Ba, V; Scherman, D; Warnery, A; Wils, P | 1 |
| Assaraf, YG; Drori, S; Eytan, GD | 1 |
| Hooper, DC; Ng, EY; Trucksis, M | 1 |
| Hagiwara, M; Hidaka, H; Miyamoto, K; Nakamura, S; Tajima, K; Wakusawa, S | 1 |
| Futai, M; Manabe, T; Moriyama, Y; Tashiro, Y; Yoshimori, T | 1 |
| Bazerque, PM; Zeitune, MG | 1 |
| Gerner, EW; Gillies, RJ; Xie, X | 1 |
| Chakrabarti, P; Choudhuri, BS; Sen, S | 1 |
| Barik, R; Basu, J; Bhakta, S; Chakrabarti, P; Choudhuri, BS; Kundu, M | 1 |
| Amaral, L; Bettencourt, R; Jordaan, AM; Leandro, C; Ordway, D; Portugal, I; Victor, TC; Viveiros, M | 1 |
| Amaral, L; Kristiansen, JE; Kristiansen, MM; Leandro, C; Martins, M; Ordway, D; Pacheco, T; Viveiros, M | 1 |
| Arcesi, F; Bellinzoni, M; De Rossi, E; Guglierame, P; Pasca, MR; Riccardi, G | 1 |
| Butaye, P; Butterworth, TS; Christensen, JB; Hendricks, O; Kolmos, HJ; Kristiansen, JE; Molnar, A | 1 |
| Drudy, D; Fanning, S; Kyne, L; O'Gaora, P; O'Mahony, R; Quinn, T | 1 |
| Nemes, P; Vertes, A | 1 |
| Amaral, L; Couto, I; Martins, A; Martins, M; Molnar, J; Rodrigues, L; Spengler, G; Viveiros, M | 1 |
| Balganesh, M; Kuruppath, S; Marcel, N; Nair, A; Sharma, S; Sharma, U | 1 |
| Guo, N; Jin, J; Li, L; Li, Y; Liang, JC; Liu, MY; Sheng, H; Wang, XL; Wu, XP; Yu, L; Zhang, JY | 1 |
| Gey van Pittius, NC; Grobbelaar, M; Hernandez-Pando, R; Jimenez, A; Leon, R; Louw, GE; McEvoy, CR; Murray, M; van Helden, PD; Victor, TC; Warren, RM | 1 |
| Alfonso, S; Battilocchio, C; Biava, M; Botta, M; Buroni, S; Canseco, JO; De Logu, A; De Rossi, E; Ioerger, TR; Javid, B; La Rosa, V; Manetti, F; Pasca, MR; Poce, G; Porretta, GC; Raju, RM; Rubin, EJ; Sacchettini, JC; Sorrentino, F | 1 |
| Duesberg, CB; Fuehner, T; Klugman, KP; Makarewicz, O; Michaylov, N; Pletz, MW; Schumacher, U; van der Linden, M; Welte, T | 1 |
| Andries, K; Coeck, N; de Jong, BC; Gevers, T; Koul, A; Lounis, N; Thys, K; Villellas, C; Vranckx, L | 1 |
| Guo, Q; Jiang, Y; Li, C; Li, G; Lu, J; Qiu, Y; Wan, K; Wei, J; Zhang, J; Zhao, LL; Zhao, X | 1 |
| Chien, JY; Hsueh, PR; Yu, CJ | 1 |
| Coban, AY; Durupınar, B; Valıyeva, G | 1 |
3 review(s) available for verapamil and reserpine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship | 2017 |
[Treatment of coronary arterial spasm].
Topics: Amiodarone; Coronary Vasospasm; Denervation; Diltiazem; Humans; Isosorbide Dinitrate; Myocardial Revascularization; Nifedipine; Nitroglycerin; Phenoxybenzamine; Phentolamine; Reserpine; Verapamil | 1982 |
1 trial(s) available for verapamil and reserpine
| Article | Year |
|---|---|
[Clinical evaluation of the effect of verapamil in hypertensive patients].
Topics: Adult; Aged; Blood Pressure; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Placebos; Reserpine; Verapamil | 1983 |
109 other study(ies) available for verapamil and reserpine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Bicinchoninic acid protein assay in the determination of adriamycin cytotoxicity modulated by the MDR glycoprotein.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Copper; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Fluorometry; Humans; Indicators and Reagents; Quality Control; Quinolines; Tumor Cells, Cultured | 1996 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genes, MDR; Humans; Intestinal Mucosa; Transfection | 2002 |
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
Topics: Animals; Caco-2 Cells; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Mitochondrial Proteins; Multidrug Resistance-Associated Protein 2; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Transfection; Vinblastine | 2002 |
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine | 2002 |
Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Clone Cells; Dogs; Gene Expression Regulation; Humans | 2003 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
New functional assay of P-glycoprotein activity using Hoechst 33342.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluoresceins; Humans; Microscopy, Fluorescence; Molecular Structure; Principal Component Analysis; Time Factors | 2007 |
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Citral derived amides as potent bacterial NorA efflux pump inhibitors.
Topics: Amides; Bacterial Proteins; Ciprofloxacin; Molecular Structure; Multidrug Resistance-Associated Proteins; Staphylococcus aureus; Structure-Activity Relationship | 2008 |
Structure-activity relationships of new inhibitors of breast cancer resistance protein (ABCG2).
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Humans; Models, Molecular; Molecular Structure; Neoplasm Proteins; Phthalic Acids; Quantitative Structure-Activity Relationship; Quinolines; Reproducibility of Results; Stereoisomerism; Time Factors; Tumor Cells, Cultured | 2008 |
Piperine analogs as potent Staphylococcus aureus NorA efflux pump inhibitors.
Topics: Alkaloids; Anti-Bacterial Agents; Bacterial Proteins; Benzodioxoles; Ciprofloxacin; Enzyme Inhibitors; Ethidium; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Nucleic Acid Synthesis Inhibitors; Piperidines; Polyunsaturated Alkamides; Staphylococcus aureus | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Substituted dihydronaphthalenes as efflux pump inhibitors of Staphylococcus aureus.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Ciprofloxacin; Drug Synergism; Membrane Transport Proteins; Microbial Sensitivity Tests; Naphthalenes; Staphylococcus aureus; Structure-Activity Relationship | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Chalcone inhibitors of the NorA efflux pump in Staphylococcus aureus whole cells and enriched everted membrane vesicles.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Biological Transport; Chalcone; Ciprofloxacin; Drug Synergism; Microbial Sensitivity Tests; Multidrug Resistance-Associated Proteins; Staphylococcus aureus | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
7-Hydroxy-(E)-3-phenylmethylene-chroman-4-one analogues as efflux pump inhibitors against Mycobacterium smegmatis mc² 155.
Topics: Anti-Bacterial Agents; Chromans; Chromones; Dose-Response Relationship, Drug; Drug Resistance, Bacterial; Microbial Sensitivity Tests; Mycobacterium smegmatis; Structure-Activity Relationship | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Development and characterization of 3-(benzylsulfonamido)benzamides as potent and selective SIRT2 inhibitors.
Topics: Acetylation; Benzamides; Magnetic Resonance Spectroscopy; Mass Spectrometry; Neuroprotective Agents; Sirtuin 2; Structure-Activity Relationship | 2014 |
Discovery and characterization of aryl isonitriles as a new class of compounds versus methicillin- and vancomycin-resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Caco-2 Cells; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Discovery; Humans; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Molecular Structure; Nitriles; Staphylococcus aureus; Structure-Activity Relationship; Vancomycin Resistance | 2015 |
Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties.
Topics: Anti-Bacterial Agents; Caco-2 Cells; Dose-Response Relationship, Drug; Humans; Hydrazines; Keratinocytes; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Structure; Structure-Activity Relationship; Thiazoles | 2016 |
Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA).
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Structure-Activity Relationship; Thiazoles; Vancomycin | 2017 |
4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice.
Topics: Administration, Oral; Aminopyridines; Aminoquinolines; Animals; Antimalarials; Cell Membrane Permeability; Chloroquine; CHO Cells; Cricetulus; Drug Evaluation, Preclinical; Drug Resistance, Microbial; ERG1 Potassium Channel; Hemeproteins; Humans; Malaria; Male; Mice, Inbred BALB C; Plasmodium berghei; Plasmodium falciparum; Solubility; Structure-Activity Relationship | 2017 |
The effect of beta-adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increased in resting tension.
Topics: Adrenergic beta-Antagonists; Animals; Calcium; Depression, Chemical; Guinea Pigs; Heart Rate; Hyperthyroidism; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Reserpine; Stimulation, Chemical; Verapamil | 1978 |
Experimental studies on the pathogenesis of asystole after verapamil in the dog.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Atrioventricular Node; Coronary Vessels; Dogs; Electrophysiology; Heart Arrest; Injections, Intra-Arterial; Norepinephrine; Propranolol; Reserpine; Verapamil | 1979 |
Effects of praziquantel, a new anthelmintic, on electromechanical properties of isolated rat atria.
Topics: Action Potentials; Animals; Anthelmintics; Dose-Response Relationship, Drug; Heart Atria; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Phentolamine; Pyrazines; Rats; Reserpine; Sodium-Potassium-Exchanging ATPase; Stimulation, Chemical; Verapamil | 1978 |
[Creatine phosphokinase release from perfused cardiac muscle under hypoxic conditions. Effect of propranolol, verapamil, reserpine and deslanoside].
Topics: Animals; Creatine Kinase; Deslanoside; Hypoxia; Lanatosides; Male; Myocardium; Propranolol; Rabbits; Reserpine; Verapamil | 1979 |
[Modification of toxicity of the calcium antagonist verapamil by depletion of catecholamines (author's transl)].
Topics: Animals; Catecholamines; Drug Synergism; Lethal Dose 50; Male; Mice; Mice, Inbred Strains; Reserpine; Verapamil | 1977 |
Cardiodepressive and noradrenaline-antagonistic effects of the organic calcium-antagonist D 600 in the spontaneously beating guinea-pig atrium.
Topics: Animals; Depression, Chemical; Electric Stimulation; Gallopamil; Guinea Pigs; Heart Rate; In Vitro Techniques; Male; Myocardial Contraction; Norepinephrine; Reserpine; Verapamil | 1977 |
Release of noradrenaline by the ionophore X537A from normal and reserpinized guinea-pig atrium.
Topics: Animals; Anti-Bacterial Agents; Calcium; Drug Interactions; Guinea Pigs; In Vitro Techniques; Lasalocid; Male; Myocardium; Norepinephrine; Perfusion; Reserpine; Ruthenium Red; Ryanodine; Tetracaine; Time Factors; Verapamil | 1977 |
Initial myocardial adjustments to brief periods of ischemia and reperfusion in the conscious dog.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Chemotherapy, Cancer, Regional Perfusion; Coronary Disease; Dogs; Heart Rate; Hemodynamics; Propranolol; Reserpine; Verapamil | 1978 |
[Therapy of hypertensive crises].
Topics: Acute Disease; Adrenal Gland Neoplasms; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazine; Guanethidine; Humans; Hypertension; Hypertension, Malignant; Hypertension, Renal; Methyldopa; Nitroprusside; Pheochromocytoma; Reserpine; Verapamil | 1977 |
Pharmacological compounds affecting plasma glucagon levels in rats.
Topics: Animals; Atropine; Blood Glucose; Depression, Chemical; Fatty Acids, Nonesterified; Glucagon; Insulin; Male; Nicotinic Acids; Physical Exertion; Procaine; Propranolol; Quinidine; Rats; Reserpine; Swimming; Verapamil | 1976 |
Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Leukemia L1210; Methotrexate; Mice; Probenecid; Prostaglandins A; Quinidine; Reserpine; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil; Vincristine | 1992 |
Effect of drugs on the lethality in mice of the venoms and neurotoxins from sundry snakes.
Topics: Animals; Dexamethasone; Diltiazem; Female; Lethal Dose 50; Mice; Mice, Inbred ICR; Neuromuscular Depolarizing Agents; Neurotoxins; Nicergoline; Nifedipine; Piperidines; Piracetam; Primaquine; Reserpine; Snake Venoms; Snakes; Verapamil | 1991 |
Changes in cardiovascular responses of conscious rats to endogenous opioids following treatment with catecholamine-depleting agents.
Topics: Animals; Atropine; Blood Pressure; Cardiovascular Physiological Phenomena; Catecholamines; Dynorphins; Endorphins; Enkephalin, Methionine; Heart Rate; Hydroxydopamines; Male; Motor Activity; Naloxone; Narcotics; Neurotoxins; Oxidopamine; Peptide Fragments; Rats; Rats, Inbred Strains; Reserpine; Verapamil | 1990 |
The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts.
Topics: Aging; Animals; Drug Interactions; Electrophysiology; Heart Conduction System; Injections, Intraperitoneal; Male; Propranolol; Rats; Rats, Inbred F344; Reserpine; Verapamil | 1991 |
Efflux of bis-carboxyethyl-carboxyfluorescein (BCECF) by a novel ATP-dependent transport mechanism in epithelial cells.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Cell Line; Epithelium; Fluoresceins; Fluorescent Dyes; Humans; Indomethacin; Kinetics; Nifedipine; Reserpine; Verapamil; Vinblastine | 1990 |
An increase in putative voltage dependent calcium channel number following reserpine treatment.
Topics: Animals; Catecholamines; Ion Channels; Male; Membrane Potentials; Muscle, Smooth; Nifedipine; Nitrendipine; Prazosin; Rats; Receptors, Adrenergic, alpha; Reserpine; Seminal Vesicles; Verapamil | 1985 |
3H-azidopine photoaffinity labeling of high molecular weight proteins in chloroquine resistant falciparum malaria.
Topics: Affinity Labels; Animals; Azides; Binding, Competitive; Chloroquine; Chlorpromazine; Dihydropyridines; Drug Resistance; Glycoproteins; Molecular Weight; Nicardipine; Photochemistry; Plasmodium falciparum; Proteins; Quinacrine; Reserpine; Trifluoperazine; Verapamil | 1989 |
Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine.
Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Survival; Chloroquine; Drug Interactions; Drug Resistance; Humans; Indoles; Leukemia; Membrane Glycoproteins; Photochemistry; Quinacrine; Quinine; Reserpine; Verapamil; Vinblastine; Vinca Alkaloids; Vindesine; Yohimbine | 1988 |
The effect of lysosomotropic agents and secretory inhibitors on anthracycline retention and activity in multiple drug-resistant cells.
Topics: Amines; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Membrane Permeability; Cytoskeleton; Drug Resistance; Ionophores; Lysosomes; Melanins; Membrane Glycoproteins; Mice; Monensin; Naphthacenes; Nigericin; Reserpine; Secretory Rate; Verapamil | 1988 |
Effects of tityustoxin on the rat isolated tail artery.
Topics: Animals; Arteries; Blood Pressure; Catecholamines; Cocaine; Dose-Response Relationship, Drug; Male; Neurotoxins; Phentolamine; Rats; Reserpine; Scorpion Venoms; Tail; Tetrodotoxin; Vasoconstriction; Verapamil | 1985 |
Effects of 4-aminopyridine on cat blood pressure in relation to the sympathetic nervous system.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Blood Pressure; Calcium; Cardiovascular Agents; Cats; Female; In Vitro Techniques; Male; Norepinephrine; Phentolamine; Reserpine; Sympathetic Nervous System; Vasoconstriction; Verapamil | 1985 |
The mechanism of action of maitotoxin in relation to Ca2+ movements in guinea-pig and rat cardiac muscles.
Topics: Animals; Calcium; Guinea Pigs; In Vitro Techniques; Male; Marine Toxins; Myocardial Contraction; Myocardium; Oxocins; Rats; Rats, Inbred Strains; Reserpine; Sodium-Potassium-Exchanging ATPase; Species Specificity; Verapamil | 1985 |
Role of sodium-calcium exchange and effects of calcium entry blockers on endothelial-mediated responses in rat isolated aorta.
Topics: Amiloride; Animals; Aorta; Bepridil; Calcium; Calcium Channel Blockers; Choline; Cyclic GMP; Diltiazem; Endothelium; Female; Lithium; Muscle, Smooth, Vascular; Nicergoline; Nifedipine; Pyrrolidines; Rats; Rats, Inbred Strains; Reserpine; Sodium; Verapamil | 1986 |
Verapamil enhances the non-adrenergic twitch response of rat vas deferens.
Topics: Animals; Autonomic Nervous System; Electric Stimulation; Gallopamil; Hydroxydopamines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Oxidopamine; Prazosin; Rats; Reserpine; Vas Deferens; Verapamil; Yohimbine | 1987 |
The membrane transport system responsible for multidrug resistance is operating in nonresistant cells.
Topics: Animals; Biological Transport, Active; Cell Line, Transformed; Cell Membrane; Cricetinae; Drug Resistance; Fibroblasts; Fluorescent Dyes; Microscopy, Fluorescence; Mitochondria; Reserpine; Rhodamine 123; Rhodamines; Trifluoperazine; Verapamil | 1988 |
Sodium-depletion-induced contractures in isolated rat vas deferens: possible role of endogenous catecholamines.
Topics: Animals; Barium; Barium Compounds; Chlorides; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Rats; Reference Values; Reserpine; Sodium; Vas Deferens; Verapamil | 1988 |
Early intraneuronal mobilization and deamination of noradrenaline during global ischemia in the isolated perfused rat heart.
Topics: Animals; Calcium; Coronary Circulation; Coronary Disease; Deamination; Desipramine; Heart; In Vitro Techniques; Male; Mandelic Acids; Methoxyhydroxyphenylglycol; Neurons; Norepinephrine; Pargyline; Rats; Rats, Inbred Strains; Reserpine; Verapamil | 1987 |
[Possibility of overcoming of ACNU resistance in an ACNU-resistant subline of C6 rat glioma].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Cells, Cultured; Drug Resistance; Drug Therapy, Combination; Glioma; Male; Nicardipine; Nimustine; Nitrosourea Compounds; Rats; Rats, Inbred Strains; Reserpine; Trifluoperazine; Verapamil | 1986 |
Evidence for Des-Tyr1-D-Ala2-leucine5-enkephalinamide calcium agonist activity in vascular smooth muscle.
Topics: Animals; Calcium; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitrendipine; Potassium Chloride; Rats; Reserpine; Serotonin; Verapamil | 1987 |
The calcium entry blockers: anti-manic drugs?
Topics: Amphetamines; Animals; Bipolar Disorder; Calcium Channel Blockers; Diltiazem; Hyperkinesis; Male; Mice; Mice, Inbred Strains; Motor Activity; Nicardipine; Oxolinic Acid; Reserpine; Verapamil | 1986 |
Mechanism and metabolic disposition of verapamil-evoked overflow of radioactivity from isolated atria preloaded with [3H]norepinephrine.
Topics: Animals; Calcium; Cocaine; Heart Atria; In Vitro Techniques; Male; Myocardium; Norepinephrine; Pargyline; Rats; Rats, Inbred Strains; Reserpine; Tetrodotoxin; Verapamil | 1985 |
Influence of verapamil on the digoxin-induced inotropic effect in guinea-pig isolated atria.
Topics: Animals; Atrial Function; Cardiac Glycosides; Digoxin; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Myocardial Contraction; Reserpine; Verapamil | 1985 |
The mechanism of Ptychodiscus brevis toxin-induced rat vas deferens contraction.
Topics: Animals; Dinoflagellida; Dose-Response Relationship, Drug; Male; Marine Toxins; Muscle Contraction; Muscle, Smooth; Neurotoxins; Norepinephrine; Rats; Receptors, Adrenergic; Reserpine; Tetrodotoxin; Vas Deferens; Verapamil | 1985 |
[Hypertensive emergencies].
Topics: Brain Edema; Clonidine; Diazoxide; Digitalis Glycosides; Diuretics; Drug Combinations; Emergencies; Ferricyanides; Ganglionic Blockers; Guanethidine; Humans; Hydralazine; Hypertension; Hypertension, Malignant; Hypnotics and Sedatives; Intensive Care Units; Methyldopa; Minoxidil; Nitric Oxide; Pheochromocytoma; Reserpine; Verapamil | 1974 |
[Influence of beta-adrenolytic substances on the action of digitalis glycosides].
Topics: Animals; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Propranolol; Quinidine; Reserpine; Strophanthins; Tachycardia; Verapamil | 1967 |
[On the influence of beta-receptor blocking agents, iproveratril, quinidine and reserpine on the effect of k-strophanthin in the guinea pig heart].
Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Muscle Contraction; Nitriles; Propranolol; Quinidine; Reserpine; Strophanthins; Sympatholytics; Vasodilator Agents; Verapamil | 1967 |
Electro-optical system for monitoring activity of heart cells in culture: application to the study of several drugs and scorpion toxins.
Topics: Acetylcholine; Animals; Bucladesine; Calcium; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Electrophysiology; Epinephrine; Heart; Heart Rate; Isoproterenol; Methods; Myocardium; Norepinephrine; Ouabain; Propranolol; Reserpine; Scorpions; Tetrodotoxin; Toxins, Biological; Trypsin; Tubocurarine; Verapamil | 1974 |
[The therapeutic modification of the primary vascular form of chronic cor pulmonale and of continuing pulmonary hypertension after commissurotomy for mitral stenosis. A comparison with control of the pulmonary artery pressure].
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Adult; Blood Pressure; Cardiac Output; Cardiac Surgical Procedures; Female; Heart Rate; Humans; Hypertension, Pulmonary; Male; Middle Aged; Mitral Valve Stenosis; Nitroglycerin; Phentolamine; Pulmonary Artery; Pulmonary Heart Disease; Reserpine; Vascular Resistance; Vasodilator Agents; Verapamil | 1970 |
[Action of antiarrhythmic and -receptor blocking drugs on functional refractory period and contractility of electrically stimulated guinea-pig atria].
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Anti-Arrhythmia Agents; Atrial Function; Drug Interactions; Electric Stimulation; Guinea Pigs; Male; Muscle Contraction; Phenytoin; Procainamide; Propranolol; Quinidine; Reserpine; Sparteine; Sympatholytics; Time Factors; Verapamil | 1971 |
Letter: Treatment for hypertension.
Topics: Drug Synergism; Humans; Hypertension; Reserpine; Verapamil | 1973 |
Letter: Drug combinations in the treatment of hypertension.
Topics: Drug Synergism; Humans; Hypertension; Reserpine; Verapamil | 1974 |
[Inhibition of adenosine uptake and stimulation of its effect on isolated hearts of warm-blooded animals by coronary active substances].
Topics: Alkaloids; Allopurinol; Animals; Carbon Isotopes; Cocaine; Depression, Chemical; Dipyridamole; Drug Synergism; Ethylenediamines; Guinea Pigs; Heart Rate; In Vitro Techniques; Myocardium; Nitroglycerin; Nucleosides; Ouabain; Papaverine; Prenylamine; Probenecid; Pyridines; Reserpine; Stimulation, Chemical; Theophylline; Triamterene; Vasodilator Agents; Verapamil | 1969 |
[Disturbances of cardiac rhythm and their treatment].
Topics: Adult; Aged; Ajmaline; Arrhythmias, Cardiac; Digitoxin; Digoxin; Humans; Lidocaine; Metaproterenol; Middle Aged; Phenytoin; Procainamide; Quinidine; Reserpine; Verapamil | 1970 |
[Therapy of hypertension].
Topics: Adrenal Gland Neoplasms; Aniline Compounds; Antihypertensive Agents; Diuretics; Female; Guanethidine; Humans; Hydralazine; Hypertension; Imidazoles; Methyldopa; Pheochromocytoma; Porphyrias; Pregnancy; Reserpine; Sympatholytics; Verapamil | 1971 |
Some effects of iproveratril (Isoptin) on the cardiovascular system.
Topics: Abdomen; Animals; Anti-Arrhythmia Agents; Azygos Vein; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Coronary Vessels; Dogs; Extracorporeal Circulation; Glucosyltransferases; Heart Rate; In Vitro Techniques; Isoproterenol; Kidney; Myocardium; Nitriles; Papillary Muscles; Propantheline; Rabbits; Rats; Regional Blood Flow; Reserpine; Vasodilator Agents; Ventricular Function; Verapamil | 1968 |
Prevention of ventricular fibrillation induced by coronary ligation.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Vessels; Dogs; Heart Atria; Heart Rate; Injections, Intravenous; Reserpine; Vasodilator Agents; Ventricular Fibrillation; Verapamil | 1968 |
[Differential therapy of tachycardial arrhythmias].
Topics: Anti-Arrhythmia Agents; Humans; Lidocaine; Metaproterenol; Phenytoin; Procainamide; Quinidine; Reserpine; Sparteine; Sympatholytics; Tachycardia; Tachycardia, Paroxysmal; Verapamil | 1969 |
Excitatory effect of the most potent marine toxin, maitotoxin, on the guinea-pig vas deferens.
Topics: Animals; Calcium; Calcium Channel Blockers; Cell Membrane; Chlorpheniramine; Dose-Response Relationship, Drug; Guinea Pigs; Ion Channels; Male; Marine Toxins; Muscle Contraction; Muscle, Smooth; Nicardipine; Nifedipine; Norepinephrine; Oxocins; Phentolamine; Reserpine; Tetrodotoxin; Vas Deferens; Verapamil | 1983 |
An analysis of the positive inotropic effect of AR-L 115 BS on isolated rat atria.
Topics: Animals; Caffeine; Calcium; Cardiotonic Agents; Electric Stimulation; Heart Rate; Imidazoles; In Vitro Techniques; Isoproterenol; Membrane Potentials; Myocardial Contraction; Practolol; Rats; Rats, Inbred Strains; Reserpine; Sinoatrial Node; Sodium; Verapamil | 1984 |
A reserpine-like action of verapamil on cardiac sympathetic nerves.
Topics: Animals; Heart Atria; Male; Myocardium; Norepinephrine; Rats; Rats, Inbred Strains; Reserpine; Sympathetic Nervous System; Verapamil | 1984 |
Acute hypertensive crises.
Topics: Acute Disease; Adult; Aged; Clonidine; Diazoxide; Heart Block; Humans; Hypertension; Injections, Intravenous; Myocardial Infarction; Nitroprusside; Reserpine; Verapamil | 1980 |
Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats.
Topics: Animals; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Mucins; Hydralazine; Indomethacin; Male; Rats; Rats, Wistar; Reserpine; Stomach Ulcer; Stress, Physiological; Verapamil | 1994 |
Digoxin-induced ventricular arrhythmias in the guinea pig heart in vivo: evidence for a role of endogenous catecholamines in the genesis of delayed afterdepolarizations and triggered activity.
Topics: Adenosine; Analysis of Variance; Animals; Arrhythmias, Cardiac; Catecholamines; Digoxin; Disease Models, Animal; Electrocardiography; Female; Guinea Pigs; Male; Propranolol; Random Allocation; Reserpine; Ventricular Dysfunction; Verapamil | 1995 |
Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Chlorpromazine; Epithelium; Humans; Intestinal Mucosa; Reserpine; Verapamil; Vinblastine; Virginiamycin | 1995 |
Potentiation of anticancer-drug cytotoxicity by multidrug-resistance chemosensitizers involves alterations in membrane fluidity leading to increased membrane permeability.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane Permeability; CHO Cells; Cricetinae; Drug Resistance, Multiple; Drug Synergism; Humans; Membrane Fluidity; Reserpine; Tumor Cells, Cultured; Verapamil | 1995 |
Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome.
Topics: Amino Acid Sequence; Anti-Infective Agents; Base Sequence; Biological Transport; Chromosome Mapping; Chromosomes, Bacterial; Cloning, Molecular; Drug Resistance, Microbial; Magnesium; Molecular Sequence Data; Norfloxacin; Reserpine; RNA, Messenger; Staphylococcus aureus; Verapamil | 1994 |
Effects of isoquinolinesulphonamide compounds on multidrug-resistant P388 cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cell Membrane; Drug Resistance; Immunoblotting; Isoquinolines; Leukemia P388; Membrane Glycoproteins; Mice; Protein Kinase C; Protein Kinase Inhibitors; Reserpine; Sulfonamides; Tumor Cells, Cultured; Verapamil; Vinblastine | 1993 |
ATP-dependent uptake of anti-neoplastic agents by acidic organelles.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Antineoplastic Agents; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cattle; Cells, Cultured; Chromaffin Granules; Daunorubicin; Drug Resistance; Hydrogen-Ion Concentration; Mice; Nigericin; Organelles; Proteolipids; Proton-Translocating ATPases; Quinidine; Reserpine; Valinomycin; Vanadates; Verapamil | 1994 |
Effects of ovarian hormone treatment on Ca(2+)-induced contractions and Ca(2+)-antagonism in the depolarized rat myometrium.
Topics: Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Castration; Dose-Response Relationship, Drug; Drug Therapy, Combination; Estradiol; Female; In Vitro Techniques; Myometrium; Neuromuscular Depolarizing Agents; Potassium Chloride; Progesterone; Rats; Rats, Wistar; Regression Analysis; Reserpine; Uterine Contraction; Verapamil | 1996 |
Characterization of a diamine exporter in Chinese hamster ovary cells and identification of specific polyamine substrates.
Topics: Animals; Biological Transport; CHO Cells; Cricetinae; Hydrogen-Ion Concentration; Putrescine; Reserpine; Valinomycin; Verapamil | 1997 |
Isoniazid accumulation in Mycobacterium smegmatis is modulated by proton motive force-driven and ATP-dependent extrusion systems.
Topics: Adenosine Triphosphate; Antitubercular Agents; Biological Transport, Active; Calcium Channel Blockers; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Diltiazem; Drug Resistance, Microbial; Hydrogen-Ion Concentration; Ionophores; Isoniazid; Mycobacterium smegmatis; Nifedipine; Nigericin; Proton-Motive Force; Reserpine; Uncoupling Agents; Valinomycin; Vanadates; Verapamil | 1999 |
Overexpression and functional characterization of an ABC (ATP-binding cassette) transporter encoded by the genes drrA and drrB of Mycobacterium tuberculosis.
Topics: Adenosine Triphosphate; Adrenergic Uptake Inhibitors; Amino Acid Sequence; Antibiotics, Antineoplastic; ATP-Binding Cassette Transporters; Bacterial Proteins; Base Sequence; Biological Transport; Calcium Channel Blockers; Cloning, Molecular; Daunorubicin; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Escherichia coli; Lipid Metabolism; Molecular Sequence Data; Mycobacterium tuberculosis; Reserpine; Verapamil | 2002 |
Isoniazid-induced transient high-level resistance in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Calcium Channel Blockers; Drug Resistance, Bacterial; Isoniazid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Peroxidases; Polymorphism, Restriction Fragment Length; Reserpine; Reverse Transcriptase Polymerase Chain Reaction; Verapamil | 2002 |
Phenothiazines alter resistance of methicillin-resistant strains of Staphylococcus aureus (MRSA) to oxacillin in vitro.
Topics: Anti-Bacterial Agents; Biological Transport, Active; Chlorpromazine; Drug Resistance, Bacterial; Methicillin Resistance; Oxacillin; Phenothiazines; Reserpine; Staphylococcus aureus; Thioridazine; Verapamil | 2003 |
Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.
Topics: Anti-Infective Agents; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Ciprofloxacin; DNA Primers; Drug Resistance; Energy Metabolism; Fluoroquinolones; Gene Expression Regulation, Bacterial; Hydrazones; Mycobacterium smegmatis; Mycobacterium tuberculosis; Operon; Reserpine; Verapamil | 2004 |
In vitro activity of phenothiazine derivatives in Enterococcus faecalis and Enterococcus faecium.
Topics: Ampicillin; Animals; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Culture Media; Drug Resistance, Multiple, Bacterial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Microbial Sensitivity Tests; Penicillins; Phenothiazines; Reserpine; Verapamil | 2005 |
High-level resistance to moxifloxacin and gatifloxacin associated with a novel mutation in gyrB in toxin-A-negative, toxin-B-positive Clostridium difficile.
Topics: Amino Acid Substitution; Anti-Bacterial Agents; Aza Compounds; Bacterial Proteins; Bacterial Toxins; Clostridioides difficile; Dipeptides; DNA Gyrase; DNA, Bacterial; Drug Resistance, Bacterial; Enterotoxins; Enzyme Inhibitors; Fluoroquinolones; Gatifloxacin; Microbial Sensitivity Tests; Molecular Sequence Data; Moxifloxacin; Mutation; Polymerase Chain Reaction; Quinolines; Reserpine; Ribotyping; Sequence Analysis, DNA; Verapamil | 2006 |
Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry.
Topics: Atmospheric Pressure; Humans; Molecular Weight; Particle Size; Plant Leaves; Plant Roots; Plant Stems; Proteins; Reserpine; Seedlings; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Tagetes; Terfenadine; Verapamil | 2007 |
Demonstration of the activity of P-glycoprotein by a semi-automated fluorometric method.
Topics: Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Automation; Biological Transport; Calcium Channel Blockers; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Ethidium; Fluorometry; Humans; Lymphoma, T-Cell; Mice; Reserpine; Verapamil | 2009 |
Rv1218c, an ABC transporter of Mycobacterium tuberculosis with implications in drug discovery.
Topics: Antitubercular Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Drug Discovery; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Pyrazolones; Reserpine; Verapamil | 2010 |
Farnesol, a potential efflux pump inhibitor in Mycobacterium smegmatis.
Topics: Antitubercular Agents; Bacterial Proteins; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chlorpromazine; Farnesol; Membrane Transport Proteins; Microbial Sensitivity Tests; Mycobacterium smegmatis; Nitriles; Reserpine; Verapamil | 2010 |
Rifampicin reduces susceptibility to ofloxacin in rifampicin-resistant Mycobacterium tuberculosis through efflux.
Topics: Adrenergic Uptake Inhibitors; Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bacterial Proteins; Calcium Channel Blockers; Cell Culture Techniques; Disease Models, Animal; DNA-Directed RNA Polymerases; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Ofloxacin; Reserpine; Reverse Transcriptase Polymerase Chain Reaction; Rifampin; Tuberculosis, Multidrug-Resistant; Verapamil | 2011 |
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.
Topics: Animals; Antitubercular Agents; Carbon Radioisotopes; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cattle; DNA Mutational Analysis; Drug Resistance, Multiple, Bacterial; Genome, Bacterial; Genomic Library; Humans; Membrane Transport Proteins; Microbial Sensitivity Tests; Mutation; Mycobacterium bovis; Mycobacterium Infections, Nontuberculous; Mycobacterium smegmatis; Mycobacterium tuberculosis; Piperazines; Pyrroles; Reserpine; Verapamil | 2012 |
Antihypertensives suppress the emergence of fluoroquinolone-resistant mutants in pneumococci: an in vitro study.
Topics: Anti-Bacterial Agents; Antihypertensive Agents; Ciprofloxacin; DNA, Bacterial; Drug Resistance, Bacterial; Fluoroquinolones; Humans; Mutation Rate; Pneumococcal Infections; Reserpine; Sequence Analysis, DNA; Streptococcus pneumoniae; Verapamil | 2013 |
Acquired resistance of Mycobacterium tuberculosis to bedaquiline.
Topics: Animals; Antitubercular Agents; Bacterial Proteins; Base Sequence; Clofazimine; Diarylquinolines; Drug Resistance, Bacterial; Genes, Bacterial; Genetic Fitness; Humans; Mice; Microbial Sensitivity Tests; Models, Biological; Molecular Sequence Data; Mutation; Mycobacterium tuberculosis; Reserpine; Tuberculosis; Up-Regulation; Verapamil | 2014 |
Antimycobacterial activity of five efflux pump inhibitors against Mycobacterium tuberculosis clinical isolates.
Topics: Adult; Antitubercular Agents; Carbonyl Cyanide m-Chlorophenyl Hydrazone; China; Chlorpromazine; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Reserpine; Thioridazine; Tuberculosis, Pulmonary; Verapamil | 2016 |
High incidence of fluoroquinolone resistance and effect of efflux pump inhibitors on moxifloxacin resistance among Mycobacterium tuberculosis isolates causing urinary tract infection in Taiwan.
Topics: Anti-Bacterial Agents; Biological Transport, Active; Carbonyl Cyanide m-Chlorophenyl Hydrazone; DNA Gyrase; Drug Resistance, Bacterial; Enzyme Inhibitors; Fluoroquinolones; Humans; Incidence; Microbial Sensitivity Tests; Moxifloxacin; Mycobacterium tuberculosis; Prevalence; Reserpine; Taiwan; Tuberculosis, Urogenital; Verapamil | 2017 |
Efflux pump effects on
Topics: Anti-Bacterial Agents; Antitubercular Agents; Bacterial Proteins; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Drug Resistance; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Reserpine; Verapamil | 2023 |