verapamil has been researched along with quinine in 111 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (9.01) | 18.7374 |
| 1990's | 49 (44.14) | 18.2507 |
| 2000's | 35 (31.53) | 29.6817 |
| 2010's | 14 (12.61) | 24.3611 |
| 2020's | 3 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Assaraf, YG; Borgnia, MJ; Eytan, GD | 1 |
| Dresser, MJ; Giacomini, KM; Gray, AT; Terashita, S; Yost, SC; Zhang, L | 1 |
| Giacomini, KM; Schaner, ME; Zhang, L | 1 |
| Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Blom-Roosemalen, MC; Breimer, DD; de Boer, AG; van der Sandt, IC | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Pajeva, IK; Wiese, M | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Caron, G; Ermondi, G | 1 |
| Engel, K; Wang, J | 1 |
| Chen, X; Chong, CR; Liu, JO; Shi, L; Sullivan, DJ | 1 |
| Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
| Briand, X; Faller, B; Lázaro, E; Lowe, PJ | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Masseno, V; Muriithi, S; Nzila, A | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Avdeef, A; Tam, KY | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Wang, J | 1 |
| Dargó, G; Garádi, Z; Hámori, L; Kisszékelyi, P; Kupai, J; Nagy, S; Pósa, SP; Szakács, G; Tóth, S | 1 |
| Hedman, A | 1 |
| Dalton, WS; Emerson, S; Lehnert, M; Roe, D; Salmon, SE | 1 |
| Dorr, RT; Liddil, JD | 1 |
| Bidan, JM; Caillot, D; Chauffert, B; Dumas, M; Guy, H; Solary, E; Velay, I | 1 |
| Bedenne, L; Caillot, D; Chauffert, B; Corda, C; Martin, F; Pelletier, H; Solary, E | 1 |
| Hahn, EW; Osswald, H; Pommerenke, EW; Volm, M | 1 |
| Bazill, GW; Dexter, TM | 1 |
| Bolufer, J; Calonge, ML; Ilundáin, A; Montero, MC | 1 |
| Amigorena, S; Choquet, D; Fridman, WH; Korn, H; Teillaud, JL | 1 |
| Farber, HI | 1 |
| Gupta, S | 1 |
| Savage, AO | 1 |
| Dos Reis, GA; Nóbrega, AF; Persechini, PM | 1 |
| Aubin, JE; Ferrier, J; Heersche, JN; Ward-Kesthely, A | 1 |
| Beck, WT; Cirtain, MC; Felsted, RL; Glover, CJ; Safa, AR | 1 |
| Ferrier, J; Ward, A | 1 |
| Ferrier, J; Homble, F; Ross, S; Ward-Kesthely, A | 1 |
| Baltodano, N; Gallo, BV; Weidler, DJ | 1 |
| Brockelman, CR; Bunnag, D; Satayavivad, J; Tan-ariya, P; Wongsawatkul, O | 1 |
| Chu, F; Cowman, AF; Gros, P; Karcz, S; Schurr, E; van Es, HH; Vidal, S | 1 |
| Cook, DI; Hayashi, T; Hirono, C; Young, JA | 1 |
| Bennis, S; Ichas, F; Robert, J | 1 |
| Cook, DI; Ishikawa, T | 1 |
| Delmer, A; Marie, JP; Zhou, D; Zittoun, R | 1 |
| Bennis, S; Robert, J | 1 |
| Byus, CV; Hawel, L; Tjandrawinata, RR | 1 |
| Fricker, G; Miller, DS; Schramm, U; Wenger, R | 1 |
| Dalton, WS; de Giuli, R; Emerson, S; Lehnert, M; Salmon, SE | 1 |
| Holfels, E; Mack, D; McAuley, J; McLeod, R; Milhous, WK | 1 |
| Guieu, R; Kopeyan, C; Rochat, H | 1 |
| Bhaduri, AP; De, D; Milhous, WK | 1 |
| Giacomini, KM; Ott, RJ | 1 |
| Bene, L; Damjanovich, S; Matkó, J; Mátyus, L; Nagy, P; Panyi, G; Vereb, G | 1 |
| Ortiz-Miranda, SI; Pappone, PA | 1 |
| Hume, RI; Lin, X; Nuttall, AL | 1 |
| Kucera, P; Prod'hom, B; Sabovcik, R | 1 |
| Irimajiri, A; Kakigi, A; Saito, H; Takeda, T; Takeuchi, S | 1 |
| Bray, PG; Green, JE; Hawley, SR; Mungthin, M; Ritchie, GY; Ward, SA | 1 |
| Alván, G; Idrizbegovic, E; Jäger, W; Karlsson, KK | 1 |
| Dalton, WS; Dorr, RT; Mosley, K; Salmon, SE; Taylor, CW | 1 |
| Belhoussine, R; Manfait, M; Morjani, H | 1 |
| Belhoussine, R; Lahlil, R; Manfait, M; Morjani, H | 1 |
| Dilda, P; Dubois, JM; Gérard, V; Rouzaire-Dubois, B | 1 |
| Hedman, A; Meijer, DK | 2 |
| Ando, M; Takeuchi, S | 2 |
| De Smet, P; Li, J; Van Driessche, W | 1 |
| Belhoussine, R; Manfait, M; Millot, JM; Morjani, H; Sharonov, S | 1 |
| Clauss, W; Heinke, B | 1 |
| Bosslet, K; Czech, J; Desbene, S; Florent, JC; Gerken, M; Koch, M; Michel, S; Monneret, C; Schmidt, F; Straub, R; Tillequin, F; Van, HD | 1 |
| Bray, PG; Mungthin, M; Ward, SA | 1 |
| Konings, WN; Koole, LA; Putman, M; van Veen, HW | 1 |
| Caruana, SR; Cowman, AF; Kirk, K; Reed, MB; Saliba, KJ | 1 |
| Huang, DY; Osswald, H; Vallon, V | 1 |
| Balcerzak, SP; Fisher, RI; Gaynor, ER; Grogan, TM; LeBlanc, M; Miller, TP; Mills, GM; Unger, JM; Varterasian, M; White, LA | 1 |
| Del Mar, CB; Glasziou, PP; Hilton, DJ; Sanders, SL; Spinks, AB | 1 |
| Bittinger, F; Brockerhoff, P; Deutsch, C; Kilbinger, H; Kirkpatrick, CJ; Roth, E; Wessler, I | 1 |
| Cooper, RA; Ferdig, MT; Fidock, DA; Fujioka, H; Mu, J; Nomura, T; Roepe, PD; Su, XZ; Ursos, LM; Wellems, TE | 1 |
| Fidock, DA; Sidhu, AB; Verdier-Pinard, D | 1 |
| Ciach, M; Crandall, I; Kain, KC; Zong, K | 1 |
| Lantvit, D; Lim, E; Pezzuto, JM; Tamez, PA | 1 |
| Anglicheau, D; Beaune, P; Cassinat, B; Legendre, C; Marquet, P; Méria, P; Pallet, N; Rabant, M; Thervet, E | 1 |
| Bui, T; Ho, RJ; Hsiao, P; Unadkat, JD | 1 |
| Lanzer, M; Sanchez, CP; Stein, WD | 1 |
| Guay, DR | 1 |
| Ferguson, PD; Jiang, Z; Smith, NW; Taylor, MR | 1 |
| Chmielewski, J; Emmert, D; Hrycyna, CA; Pires, MM | 1 |
| Brun, R; Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, MK; Smilkstein, MJ; Winter, R; Wittlin, S | 1 |
| Cadagan, D; Merry, S | 1 |
| Bellanca, S; Dave, A; Dittmer, M; Lanzer, M; Martin, RE; Meyrath, M; Nash, MN; Sanchez, CP; Stein, WD; Summers, RL | 1 |
| Kawai, T; Kuninishi, Y; Muraki, Y; Nogawa, H | 1 |
| Christini, DJ; Clark, AP; Kalola, D; Krogh-Madsen, T; Wei, S | 1 |
6 review(s) available for verapamil and quinine
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Topics: Animals; Biogenic Amines; Humans; Plasma Membrane Neurotransmitter Transport Proteins; Xenobiotics | 2016 |
[Trials of modulating the MDR1 phenotype in malignant hemopathies].
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dexamethasone; Doxorubicin; Drug Resistance, Multiple; Humans; Leukemia, Myeloid, Acute; Multiple Myeloma; Quinine; Verapamil; Vincristine | 1994 |
[Effect of quinine on the multiple drug resistance and intracellular distribution of pirarubicin in LR73 tumor cells: a comparative study with verapamil and S9788 by confocal laser microspectrofluorometry].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cricetinae; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; In Vitro Techniques; Microscopy, Confocal; Piperidines; Quinine; Spectrometry, Fluorescence; Triazines; Tumor Cells, Cultured; Verapamil | 1997 |
Are there alternatives to the use of quinine to treat nocturnal leg cramps?
Topics: Amines; Calcium Channel Blockers; Carisoprodol; Cyclohexanecarboxylic Acids; Gabapentin; gamma-Aminobutyric Acid; Humans; Leg; Muscle Cramp; Muscle Relaxants, Central; Orphenadrine; Quinine; Renal Dialysis; Verapamil; Vitamin E | 2008 |
4 trial(s) available for verapamil and quinine
| Article | Year |
|---|---|
Verapamil vs quinine in recumbent nocturnal leg cramps in the elderly.
Topics: Aged; Aged, 80 and over; Circadian Rhythm; Clinical Trials as Topic; Female; Humans; Leg; Male; Middle Aged; Muscle Cramp; Posture; Quinine; Verapamil | 1988 |
[Trials of modulating the MDR1 phenotype in malignant hemopathies].
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Dexamethasone; Doxorubicin; Drug Resistance, Multiple; Humans; Leukemia, Myeloid, Acute; Multiple Myeloma; Quinine; Verapamil; Vincristine | 1994 |
Combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dexamethasone (CVAD) plus oral quinine and verapamil in patients with advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Dexamethasone; Doxorubicin; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Humans; Middle Aged; Neoplasm Metastasis; Quinine; Treatment Outcome; Tumor Stem Cell Assay; Verapamil; Vincristine | 1997 |
Infusional CHOP chemotherapy (CVAD) with or without chemosensitizers offers no advantage over standard CHOP therapy in the treatment of lymphoma: a Southwest Oncology Group Study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dexamethasone; Disease-Free Survival; Dose-Response Relationship, Drug; Doxorubicin; Humans; Infusions, Intravenous; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Middle Aged; Prednisone; Quinine; Randomized Controlled Trials as Topic; Retrospective Studies; Survival Rate; Verapamil; Vincristine | 2001 |
102 other study(ies) available for verapamil and quinine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Competition of hydrophobic peptides, cytotoxic drugs, and chemosensitizers on a common P-glycoprotein pharmacophore as revealed by its ATPase activity.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; CHO Cells; Clone Cells; Computer Simulation; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Emetine; Gramicidin; Ionophores; Kinetics; Mathematics; Models, Theoretical; N-Formylmethionine Leucyl-Phenylalanine; Oligopeptides; Valinomycin | 1996 |
Cloning and functional expression of a human liver organic cation transporter.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Liver; Membrane Proteins; Molecular Sequence Data; Oocytes; Organic Cation Transporter 1; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Xenopus laevis | 1997 |
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Cell Polarity; Cimetidine; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Epithelial Cells; Humans; Kinetics; LLC-PK1 Cells; Rhodamine 123; Swine; Tumor Cells, Cultured; Verapamil | 2000 |
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine | 2002 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Dogs; Equilibrative Nucleoside Transport Proteins; Humans; Membrane Transport Proteins; Nerve Tissue Proteins; Organic Cation Transport Proteins; Tyramine | 2005 |
A clinical drug library screen identifies astemizole as an antimalarial agent.
Topics: Animals; Antimalarials; Astemizole; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance; Drug Resistance, Multiple; Humans; Mice; Plasmodium falciparum; Plasmodium yoelii | 2006 |
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
New approach to measure protein binding based on a parallel artificial membrane assay and human serum albumin.
Topics: Humans; Kinetics; Membranes, Artificial; Permeability; Protein Binding; Serum Albumin | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Cytotoxicity of cinchona alkaloid organocatalysts against MES-SA and MES-SA/Dx5 multidrug-resistant uterine sarcoma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cinchona Alkaloids; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Quinine; Sarcoma; Soft Tissue Neoplasms; Uterine Neoplasms | 2022 |
Inhibition by basic drugs of digoxin secretion into human bile.
Topics: Bile; Chromatography, High Pressure Liquid; Digoxin; Drug Interactions; Humans; Probenecid; Quinidine; Quinine; Radioimmunoassay; Spironolactone; Verapamil | 1992 |
Synergistic inhibition by verapamil and quinine of P-glycoprotein-mediated multidrug resistance in a human myeloma cell line model.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance; Drug Synergism; Humans; In Vitro Techniques; Membrane Glycoproteins; Plasmacytoma; Quinine; Tumor Cells, Cultured; Verapamil | 1991 |
Modulation of mitomycin C-induced multidrug resistance in vitro.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance; Membrane Glycoproteins; Mice; Mitomycin; Mitomycins; Progesterone; Quinine; Tumor Cells, Cultured; Verapamil | 1991 |
Sufficient levels of quinine in the serum circumvent the multidrug resistance of the human leukemic cell line K562/ADM.
Topics: Doxorubicin; Drug Resistance; Feasibility Studies; Humans; Leukemia; Leukemia, Myeloid, Acute; Multiple Myeloma; Quinine; Tumor Cells, Cultured; Verapamil | 1991 |
Potential usefulness of quinine to circumvent the anthracycline resistance in clinical practice.
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Drug Synergism; Epirubicin; In Vitro Techniques; Quinidine; Quinine; Rats; Verapamil | 1990 |
Activity of various amphiphilic agents in reversing multidrug resistance of L 1210 cells.
Topics: Animals; Drug Resistance; Ethylamines; Hycanthone; Leukemia L1210; Phenotype; Piperidines; Quinidine; Quinine; Tamoxifen; Trifluoperazine; Verapamil | 1990 |
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil | 1990 |
Effect of K+ channel-blockers on sugar uptake by isolated chicken enterocytes.
Topics: 3-O-Methylglucose; Animals; Barium; Biological Transport, Active; Calcium; Chickens; In Vitro Techniques; Intestinal Mucosa; Methylglucosides; Methylglycosides; Potassium; Potassium Channels; Quinine; Sodium; Theophylline; Verapamil | 1990 |
Ion channel blockers inhibit B cell activation at a precise stage of the G1 phase of the cell cycle. Possible involvement of K+ channels.
Topics: 4-Aminopyridine; Animals; Antibodies, Monoclonal; B-Lymphocytes; Cell Cycle; Electric Conductivity; Lipopolysaccharides; Lymphocyte Activation; Mice; Potassium Channels; Quaternary Ammonium Compounds; Quinine; Tetraethylammonium; Tetraethylammonium Compounds; Thymidine; Time Factors; Verapamil | 1990 |
Verapamil vs quinine in recumbent nocturnal leg cramps in the elderly.
Topics: Aged; Diphenhydramine; Humans; Muscle Cramp; Quinine; Verapamil | 1990 |
Autologous mixed-lymphocyte reaction in man. XVII. In vitro effect of ion channel-blocking agents on the autologous mixed-lymphocyte response.
Topics: 4-Aminopyridine; Aminopyridines; Dose-Response Relationship, Drug; Humans; Interleukin-2; Ion Channels; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Quaternary Ammonium Compounds; Quinine; Receptors, Immunologic; Receptors, Interleukin-2; Recombinant Proteins; T-Lymphocytes; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1987 |
A comparison of the actions of 4-aminopyridine, caffeine and quinine on the toad isolated rectus abdominis muscle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Bufonidae; Caffeine; Egtazic Acid; In Vitro Techniques; Manganese; Muscle Contraction; Muscle, Smooth; Neuromuscular Depolarizing Agents; Potassium; Procaine; Quinine; Verapamil | 1989 |
Stage-specific distinctions in potassium channel blocker control of T-lymphocyte activation.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Kinetics; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mitogens; Potassium Channels; Quinine; Receptors, Mitogen; T-Lymphocytes; Tetraethylammonium Compounds; Verapamil | 1988 |
Membrane potential changes, cAMP stimulation and contraction in osteoblast-like UMR 106 cells in response to calcitonin and parathyroid hormone.
Topics: Animals; Bucladesine; Calcimycin; Calcitonin; Cell Line; Dinoprostone; Isoproterenol; Membrane Potentials; Osteoblasts; Parathyroid Hormone; Potassium Channels; Quinine; Rats; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1988 |
Effects of indole alkaloids on multidrug resistance and labeling of P-glycoprotein by a photoaffinity analog of vinblastine.
Topics: Affinity Labels; Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Survival; Chloroquine; Drug Interactions; Drug Resistance; Humans; Indoles; Leukemia; Membrane Glycoproteins; Photochemistry; Quinacrine; Quinine; Reserpine; Verapamil; Vinblastine; Vinca Alkaloids; Vindesine; Yohimbine | 1988 |
Electrophysiological differences between bone cell clones: membrane potential responses to parathyroid hormone and correlation with the cAMP response.
Topics: Bone and Bones; Bucladesine; Calcium; Cell Line; Cyclic AMP; Electrophysiology; Humans; Membrane Potentials; Parathyroid Hormone; Potassium; Quinine; Verapamil | 1986 |
Further analysis of spontaneous membrane potential activity and the hyperpolarizing response to parathyroid hormone in osteoblastlike cells.
Topics: Animals; Bucladesine; Cell Line; Cell Membrane; Membrane Potentials; Microelectrodes; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Quinine; Rats; Verapamil | 1987 |
Flunarizine and verapamil inhibit chloroquine-resistant Plasmodium falciparum growth in vitro.
Topics: Animals; Antimalarials; Chloroquine; Chlorpromazine; Drug Resistance; Flunarizine; Mefloquine; Plasmodium falciparum; Quinine; Quinolines; Regression Analysis; Verapamil | 1987 |
Expression of the plasmodial pfmdr1 gene in mammalian cells is associated with increased susceptibility to chloroquine.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Base Sequence; Biological Transport; Cell Survival; Chloroquine; CHO Cells; Colchicine; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; DNA, Protozoan; Doxorubicin; Drug Resistance; Female; Gene Expression; Genes, Protozoan; Membrane Proteins; Oligonucleotides, Antisense; Oocytes; Plasmodium falciparum; Primaquine; Protozoan Proteins; Quinine; Restriction Mapping; Verapamil; Vinblastine; Xenopus laevis | 1994 |
The ACh-induced whole-cell currents in sheep parotid secretory cells. Do BK channels really carry the ACh-evoked whole-cell K+ current?
Topics: 4-Aminopyridine; Acetylcholine; Animals; Barium; Cell Membrane; Chlorides; Parotid Gland; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Quinidine; Quinine; Sensitivity and Specificity; Sheep; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1995 |
Differential effects of verapamil and quinine on the reversal of doxorubicin resistance in a human leukemia cell line.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Dihydropyridines; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Microscopy, Confocal; Microscopy, Fluorescence; Phenotype; Quinine; Subcellular Fractions; Tumor Cells, Cultured; Verapamil | 1995 |
Effects of K+ channel blockers on inwardly and outwardly rectifying whole-cell K+ currents in sheep parotid secretory cells.
Topics: Animals; Barium; Cesium; Charybdotoxin; In Vitro Techniques; Lidocaine; Membrane Potentials; Parotid Gland; Potassium; Potassium Channels; Quinidine; Quinine; Scorpion Venoms; Sheep; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1993 |
[Difference between the effects of S9788, verapamil and quinine on the reversion of multidrug resistance in two human tumor cell lines].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Death; Doxorubicin; Drug Resistance, Multiple; Humans; Leukemia, Erythroblastic, Acute; Piperidines; Quinine; Triazines; Tumor Cells, Cultured; Verapamil | 1994 |
Characterization of putrescine and cadaverine export in mammalian cells. A pharmacological approach.
Topics: Animals; Cadaverine; Calcium; Cell Line; Culture Media; Mice; Phosphorylation; Protein Kinase Inhibitors; Putrescine; Quinine; Rats; Sodium; Verapamil | 1994 |
P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Fluorescent Dyes; Kidney Tubules, Proximal; Killifishes; Kinetics; Microscopy, Fluorescence; p-Aminohippuric Acid; Potassium Cyanide; Quinine; Tetraethylammonium; Tetraethylammonium Compounds; Time Factors; Verapamil; Vinblastine | 1995 |
In vitro evaluation of chemosensitizers for clinical reversal of P-glycoprotein-associated Taxol resistance.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Drug Resistance; Humans; Membrane Glycoproteins; Multiple Myeloma; Paclitaxel; Quinine; Trifluoperazine; Tumor Cells, Cultured; Verapamil | 1993 |
In vitro effects of artemisinin ether, cycloguanil hydrochloride (alone and in combination with sulfadiazine), quinine sulfate, mefloquine, primaquine phosphate, trifluoperazine hydrochloride, and verapamil on Toxoplasma gondii.
Topics: Animals; Artemisinins; Female; Mefloquine; Mice; Primaquine; Proguanil; Quinine; Sesquiterpenes; Sulfadiazine; Toxoplasma; Triazines; Trifluoperazine; Uracil; Verapamil | 1994 |
Utilization of aspirin, quinine and verapamil in the prevention and treatment of scorpion venom intoxication.
Topics: Animals; Aspirin; Female; gamma-Aminobutyric Acid; Lethal Dose 50; Mice; Mice, Inbred C57BL; Poisoning; Quinine; Scorpion Venoms; Valproic Acid; Verapamil | 1993 |
A novel pyrrolidonoalkaneamine (WR268954) that modulates chloroquine resistance of Plasmodium falciparum in vitro.
Topics: Animals; Anisoles; Antimalarials; Chloroquine; Drug Resistance; Drug Synergism; Molecular Structure; Plasmodium falciparum; Pyrrolidines; Quinine; Verapamil | 1993 |
Stereoselective interactions of organic cations with the organic cation transporter in OK cells.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cations; Cell Line; Disopyramide; Kidney; Microvilli; Opossums; Pindolol; Quinine; Stereoisomerism; Tetraethylammonium Compounds; Verapamil | 1993 |
Biphasic effect of extracellular ATP on the membrane potential of mouse thymocytes.
Topics: Adenosine Triphosphate; Animals; Kinetics; Membrane Potentials; Mice; Mice, Inbred BALB C; Quinine; Thymus Gland; Verapamil | 1993 |
Blockers of voltage-gated K channels inhibit proliferation of cultured brown fat cells.
Topics: Adipose Tissue, Brown; Animals; Animals, Newborn; Calcium; Cell Division; Cells, Cultured; Kinetics; Membrane Potentials; Nifedipine; Norepinephrine; Potassium Channels; Quinine; Rats; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1993 |
Dihydropyridines and verapamil inhibit voltage-dependent K+ current in isolated outer hair cells of the guinea pig.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Cochlea; Guinea Pigs; Hair Cells, Auditory, Outer; Membrane Potentials; Nifedipine; Nimodipine; Patch-Clamp Techniques; Potassium Channel Blockers; Quinine; Verapamil | 1995 |
Characterization of a whole-cell Ca2+-blockable monovalent cation current in isolated ectodermal cells of chick embryo.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane Permeability; Chick Embryo; Ectoderm; Glutamates; Hydroxides; Nifedipine; Protons; Quinine; Verapamil | 1996 |
Intravascularly applied K(+)-channel blockers suppress differently the positive endocochlear potential maintained by vascular perfusion.
Topics: Analgesics, Non-Narcotic; Animals; Barium; Calcium Channel Blockers; Cerebellum; Cochlear Microphonic Potentials; Guinea Pigs; Potassium Channel Blockers; Quinine; Stria Vascularis; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1996 |
In vitro selection of halofantrine resistance in Plasmodium falciparum is not associated with increased expression of Pgh1.
Topics: Animals; Antimalarials; ATP-Binding Cassette Transporters; Biological Transport; Chloroquine; DNA Fingerprinting; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Gene Dosage; Gene Expression; Immunoblotting; Mefloquine; Phenanthrenes; Plasmodium falciparum; Protozoan Proteins; Quinine; Selection, Genetic; Sequence Analysis, DNA; Verapamil | 1996 |
Quinine-induced hearing loss in the guinea pig is not affected by the Ca2+ channel antagonist verapamil.
Topics: Animals; Auditory Threshold; Calcium Channel Blockers; Death, Sudden; Disease Models, Animal; Drug Interactions; Guinea Pigs; Hearing Disorders; Heart Arrest; Humans; Quinine; Tinnitus; Verapamil | 1997 |
Evidence for reversal of multidrug resistance by quinine in LR73 cells without alteration of nuclear pirarubicin uptake and down-regulation of mdr1 gene expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Nucleus; CHO Cells; Cricetinae; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation; Genes, MDR; Piperidines; Quinine; Triazines; Verapamil | 1997 |
Alterations of ionic membrane permeabilities in multidrug-resistant neuroblastoma x glioma hybrid cells.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Membrane Permeability; Cell Size; Chloride Channels; Doxorubicin; Drug Resistance, Multiple; Electric Conductivity; Glioma; Hybridomas; Hydrogen-Ion Concentration; Membrane Potentials; Mice; Neuroblastoma; Proton Pumps; Quinine; Rats; Sodium Channels; Tumor Cells, Cultured; Verapamil | 1998 |
The stereoisomers quinine and quinidine exhibit a marked stereoselectivity in the inhibition of hepatobiliary transport of cardiac glycosides.
Topics: Animals; Biliary Tract; Biological Transport; Calcium Channel Blockers; Cardiac Glycosides; Cardiotonic Agents; Digoxin; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Ouabain; Quinidine; Quinine; Rats; Rats, Wistar; Stereoisomerism; Verapamil | 1998 |
Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Digoxin; In Vitro Techniques; Male; Ouabain; Quinidine; Quinine; Rats; Rats, Wistar; Stereoisomerism; Verapamil | 1998 |
Inwardly rectifying K+ currents in intermediate cells in the cochlea of gerbils: a possible contribution to the endocochlear potential.
Topics: 4-Aminopyridine; Animals; Barium; Cadmium; Cesium; Cochlear Microphonic Potentials; Endolymph; Gerbillinae; Ion Transport; Models, Neurological; Nerve Tissue Proteins; Patch-Clamp Techniques; Potassium; Potassium Channels; Potassium Channels, Inwardly Rectifying; Quinine; Stria Vascularis; Tetraethylammonium; Verapamil | 1998 |
Hypotonicity activates a lanthanide-sensitive pathway for K+ release in A6 epithelia.
Topics: Animals; Calcium; Cations; Cell Line; Cell Membrane; Cesium; Epithelial Cells; Gadolinium; Hypotonic Solutions; Kidney; Kinetics; Lanthanum; Lidocaine; Magnesium; Potassium; Potassium Channels; Quinine; Rubidium Radioisotopes; Verapamil | 1998 |
Confocal scanning microspectrofluorometry reveals specific anthracyline accumulation in cytoplasmic organelles of multidrug-resistant cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; Cell Nucleus; CHO Cells; Cricetinae; Cytoplasm; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Golgi Apparatus; Humans; Microspectrophotometry; Piperidines; Quinine; Triazines; Tumor Cells, Cultured; Verapamil | 1998 |
Potassium conductances in isolated single cells from Xenopus laevis colonic epithelium.
Topics: Animals; Barium; Cesium; Colon; Epithelial Cells; Female; Hydrogen-Ion Concentration; Ion Transport; Lidocaine; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Quinidine; Quinine; Tetraethylammonium; Verapamil; Xenopus laevis | 1999 |
Application of the ADEPT strategy to the MDR resistance in cancer chemotherapy.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Dipyridamole; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Stability; Escherichia coli; Glucuronates; Glucuronic Acid; Glucuronidase; Humans; Hydrolysis; Leukemia L1210; Prodrugs; Quinine; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Tumor Cells, Cultured; Verapamil | 1999 |
Voltage-dependent outward K(+) current in intermediate cell of stria vascularis of gerbil cochlea.
Topics: Animals; Barium; Calcium; Electric Conductivity; Electrophysiology; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Quinine; Stria Vascularis; Tetraethylammonium; Verapamil | 1999 |
Phenotypic and genotypic characteristics of recently adapted isolates of Plasmodium falciparum from Thailand.
Topics: Animals; Antimalarials; Blotting, Western; Chloroquine; DNA Fingerprinting; DNA, Protozoan; Drug Resistance; Electrophoresis, Agar Gel; Gene Dosage; Genotype; Humans; Malaria, Falciparum; Mefloquine; Penfluridol; Phenanthrenes; Phenotype; Plasmodium falciparum; Polymerase Chain Reaction; Quinine; Thailand; Verapamil | 1999 |
The secondary multidrug transporter LmrP contains multiple drug interaction sites.
Topics: Bacterial Proteins; Benzimidazoles; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Membrane; Fluorescent Dyes; Kinetics; Lactococcus lactis; Lipid Bilayers; Membrane Proteins; Membrane Transport Proteins; Nicardipine; Onium Compounds; Organophosphorus Compounds; Phospholipids; Quinine; Spectrometry, Fluorescence; Verapamil; Vinblastine; Vincristine | 1999 |
Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.
Topics: Amino Acid Substitution; Animals; Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; Chloroquine; Cloning, Molecular; Drug Resistance; Mefloquine; Mutation; Phenanthrenes; Plasmodium falciparum; Protozoan Proteins; Quinine; Sesquiterpenes; Verapamil | 2000 |
Sodium reabsorption in thick ascending limb of Henle's loop: effect of potassium channel blockade in vivo.
Topics: Adamantane; Animals; Barium; Cesium; Charybdotoxin; Dose-Response Relationship, Drug; Glyburide; Loop of Henle; Male; Models, Biological; Morpholines; Potassium; Potassium Channel Blockers; Potassium Channels; Quinine; Rats; Rats, Wistar; Sodium; Verapamil | 2000 |
Treatment alternatives for nocturnal leg cramps.
Topics: Aged; Female; Humans; Muscle Cramp; Nafronyl; Quinine; Sleep-Wake Transition Disorders; Verapamil; Vitamin E | 2001 |
Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters.
Topics: Acetylcholine; Amiloride; Cimetidine; Corticosterone; DNA, Antisense; Dose-Response Relationship, Drug; Female; Guanidine; Humans; In Vitro Techniques; Norepinephrine; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Piperidines; Placenta; Pregnancy; Procaine; Quinine; Time Factors; Verapamil | 2001 |
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.
Topics: Acridine Orange; Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Drug Interactions; Drug Resistance; Fluorescence; Membrane Proteins; Membrane Transport Proteins; Molecular Conformation; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinidine; Quinine; Verapamil | 2002 |
Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations.
Topics: Alleles; Amodiaquine; Animals; Antimalarials; Artemisinins; ATP-Binding Cassette Transporters; Chloroquine; Cloning, Molecular; Drug Resistance; Genes, Protozoan; Haplotypes; Mefloquine; Membrane Proteins; Membrane Transport Proteins; Parasitic Sensitivity Tests; Phenotype; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinine; Sesquiterpenes; Transfection; Verapamil | 2002 |
Reversal of mefloquine and quinine resistance in Plasmodium falciparum with NP30.
Topics: Animals; Antimalarials; Calcium Channel Blockers; Drug Resistance; Genotype; Humans; Malaria, Falciparum; Mefloquine; Microbial Sensitivity Tests; Plasmodium falciparum; Quinine; Surface-Active Agents; Verapamil | 2003 |
Chemosensitizing action of cepharanthine against drug-resistant human malaria, Plasmodium falciparum.
Topics: Alkaloids; Animals; Benzylisoquinolines; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Combinations; Drug Evaluation, Preclinical; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Humans; Inhibitory Concentration 50; KB Cells; Malaria, Falciparum; Male; Mice; Parasitemia; Parasitic Sensitivity Tests; Plasmodium berghei; Quinine; Verapamil | 2005 |
Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction.
Topics: Acetanilides; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Fluorescent Dyes; Humans; Immunosuppressive Agents; Kidney; Pyrroles; Quinine; Quinolines; Rhodamines; Sirolimus; Verapamil | 2006 |
In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Boron Compounds; Carbamates; Carbon Radioisotopes; Cyclosporine; Drug Interactions; Fluorescent Dyes; Furans; Humans; LLC-PK1 Cells; Positron-Emission Tomography; Quinidine; Quinine; Rats; Sulfonamides; Swine; Verapamil | 2008 |
Dissecting the components of quinine accumulation in Plasmodium falciparum.
Topics: Adenosine Triphosphate; Animals; Antimalarials; DNA, Protozoan; Erythrocytes; Humans; Hydrogen-Ion Concentration; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Trophozoites; Verapamil | 2008 |
Mixed-mode reversed-phase and ion-exchange monolithic columns for micro-HPLC.
Topics: Acrylates; Amitriptyline; Aniline Compounds; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Diltiazem; Hydrogen-Ion Concentration; Ketones; Methacrylates; Microchemistry; Molecular Structure; Particle Size; Phenols; Polycyclic Aromatic Hydrocarbons; Polymers; Porosity; Pyrazines; Quinine; Reproducibility of Results; Sensitivity and Specificity; Stearates; Surface Properties; Time Factors; Verapamil | 2008 |
Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dimerization; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Molecular Structure; Paclitaxel; Prazosin; Quinine; Rhodamine 123; Verapamil | 2009 |
Discovery of dual function acridones as a new antimalarial chemotype.
Topics: Acridones; Animals; Antimalarials; Drug Discovery; Drug Resistance; Drug Synergism; Heme; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Plasmodium yoelii; Protozoan Proteins; Quinine; Quinolines; Trophozoites; Verapamil | 2009 |
Circumvention of inherent or acquired cytotoxic drug resistance in vitro using combinations of modulating agents.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cinnarizine; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Inhibitory Concentration 50; Maximum Tolerated Dose; MCF-7 Cells; Mice; Paclitaxel; Quinine; Verapamil; Vincristine | 2013 |
Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites.
Topics: Animals; Antimalarials; Binding Sites; Binding, Competitive; Biological Transport; Cells, Cultured; Chloroquine; Drug Resistance; Female; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Plasmodium falciparum; Protozoan Proteins; Quinidine; Quinine; Verapamil; Xenopus laevis | 2014 |
Pharmacological characterisation of electrocardiogram J-T
Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifedipine; Quinidine; Quinine; Ranolazine; Sotalol; Torsades de Pointes; Verapamil | 2022 |
An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms.
Topics: Action Potentials; Arrhythmias, Cardiac; Cardiotoxicity; Cisapride; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ion Channels; Myocytes, Cardiac; Quinidine; Quinine; Verapamil | 2022 |