verapamil has been researched along with quinidine in 420 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 170 (40.48) | 18.7374 |
| 1990's | 85 (20.24) | 18.2507 |
| 2000's | 91 (21.67) | 29.6817 |
| 2010's | 62 (14.76) | 24.3611 |
| 2020's | 12 (2.86) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Daniel, H; Kobinger, W; Lillie, C; Pichler, L; Stähle, H | 1 |
| Chan, T; Chang, C; Croy, V; Hall, AM; Kuczek, T; Ruff, D | 1 |
| Dresser, MJ; Giacomini, KM; Gray, AT; Terashita, S; Yost, SC; Zhang, L | 1 |
| Giacomini, KM; Schaner, ME; Zhang, L | 1 |
| Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Cvetkovic, M; Fromm, MF; Kim, RB; Leake, B; Wilkinson, GR | 1 |
| Nezu, JI; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Choo, EF; Imamura, H; Kim, RB; Leake, B; Wandel, C; Wilkinson, GR; Wood, AJ | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Hashimoto, N; Nezu Ji, J; Nikaido, H; Ohashi, R; Oku, A; Sai, Y; Shimane, M; Tamai, I; Tsuji, A | 1 |
| Aubé, J; Borchardt, RT; Gao, J; Murase, O; Schowen, RL | 1 |
| Dagenais, C; Ducharme, J; Pollack, GM; Zong, J | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 2 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Adachi, Y; Sugiyama, Y; Suzuki, H | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Arieff, Z; Bardien-Kruger, S; Brink, P; Chandy, KG; Corfield, V; Wulff, H | 1 |
| Borchardt, RT; Horie, K; Tang, F | 3 |
| Pajeva, IK; Wiese, M | 1 |
| Dormann, SM; Haefeli, WE; Kerpen, CJ; Ketabi-Kiyanvash, N; Martin-Facklam, M; Weiss, J | 1 |
| Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A | 1 |
| Keserü, GM | 1 |
| Thakker, DR; Troutman, MD | 1 |
| Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Engel, K; Wang, J | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Chen, X; Chong, CR; Liu, JO; Shi, L; Sullivan, DJ | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Jia, L; Sun, H | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Balani, SK; Gan, LS; Li, P; Lu, C | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Doh-Ura, K; Go, ML; Nguyen, T; Sakasegawa, Y | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Andréola, ML; Bailly, F; Calmels, C; Christ, F; Cotelle, P; Debyser, Z; Lion, C; Suchaud, V | 1 |
| Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Budriesi, R; Carosati, E; Chiarini, A; Chiu, FC; Cosimelli, B; Frosini, M; Fusi, F; Ioan, P; Katneni, K; Matucci, R; Micucci, M; Saponara, S; Severi, E; Spinelli, D | 1 |
| Andréola, ML; Bailly, F; Billamboz, M; Christ, F; Cotelle, P; Debyser, Z; Lion, C; Suchaud, V | 1 |
| Wang, J | 1 |
| Bienkowski, P; Bucki, A; Gobec, S; Godyń, J; Głuch-Lutwin, M; Kazek, G; Knez, D; Kołaczkowski, M; Malawska, B; Marcinkowska, M; Mierzejewski, P; Sienkiewicz-Jarosz, H; Siwek, A; Wichur, T; Więckowska, A; Więckowski, K; Zaręba, P | 1 |
| Bharate, SB; Joshi, P; Vishwakarma, RA | 1 |
| Handzlik, J; Jastrzębska-Więsek, M; Kieć-Kononowicz, K; Kucwaj-Brysz, K; Latacz, G; Lubelska, A; Partyka, A; Wesołowska, A | 1 |
| Cleghorn, LAT; Davis, S; Epemolu, O; Ferguson, L; Green, SR; Guijarro, L; Hipskind, P; Huggett, M; Korkegian, A; Kumar, A; Lopez Moure, A; Masquelin, T; Odingo, J; Parish, T; Ray, PC; Read, KD; Riley, J; Rullas, J; Scullion, P; Shishikura, Y; Smith, A; Turner, P; Wescott, H; Wilson, C; Wyatt, PG; Zuccotto, F | 1 |
| Cini, E; De Santis, R; Giannini, G; Manera, F; Manetti, F; Milazzo, FM; Pace, S; Petricci, E; Stasi, MA; Tallarico, C; Vesci, L | 1 |
| Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L | 1 |
| Esaki, T; Kawashima, H; Komura, H; Kuroda, M; Mizuguchi, K; Natsume-Kitatani, Y; Ohashi, R; Watanabe, R | 1 |
| Chen, SH; Duan, YC; Guan, YY; He, ZH; Jin, LF; Liu, YJ; Ren, HM; Song, Y; Xu, YT; Yuan, H; Zhang, SJ | 1 |
| Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
| Julian, DG | 2 |
| Jewitt, DE | 1 |
| Curione, M; Puletti, M | 1 |
| Theisen, K | 2 |
| Donaldson, RM | 1 |
| Klein, W | 1 |
| Januskevicius, ZI; Zabela, PV; Zemaityte, DI | 1 |
| Brochier, M; Fauchier, JP | 1 |
| Bender, F | 3 |
| Merx, W | 1 |
| Vaughan-Williams, EM | 1 |
| Whipple, GH | 1 |
| Gettes, LS | 2 |
| Federman, J; Vlietstra, RE | 1 |
| Chizh, VD | 2 |
| Anderson, JL; Harrison, DC; Meffin, PJ; Winkle, RA | 1 |
| de Mendonça, JV | 1 |
| Cherian, G; Kuruvilla, A; Stephen, PM | 1 |
| Farup, PG | 1 |
| Nissimov, R | 1 |
| Hepp, A; Raff, U | 1 |
| Loogen, F | 1 |
| Elharrar, V; Gaum, WE; Zipes, DP | 1 |
| von Knorre, GH | 1 |
| McCall, D | 1 |
| Lefebvre, PJ; Luyckx, AS | 1 |
| Narimatsu, A; Taira, N | 1 |
| Dreifus, L; Satinsky, JD | 1 |
| Disertori, M; Furlanello, F; Lanzetta, T; Piccolo, E; Trevi, GP | 1 |
| Wellens, HJ | 1 |
| Araú, A; Bonhorst, D; Bordalo, A; De Azevedo, JG; Ferreira, M; Ferreira, R; Inês, L; Lacximy, I; Longo, A; Luis Martins, J; Melo, M; Nunes Diogo, A; Ribeiro, C; Sanches, C; Teixeira, J | 1 |
| Landmark, KH | 1 |
| Steinbach, K | 1 |
| Arnsdorf, MF | 1 |
| Bogoliubov, VM; Gribkova, IN; Kruglova, ZG; Lyskova, MN | 1 |
| Jing, MX; Nong, Y; Wang, JL | 1 |
| Fardel, O; Guillouzo, A; Ketterer, B; Loyer, P; Ratanasavanh, D | 1 |
| Abraham, I; Chauhan, SS; Chin, KV; Gottesman, MM; Krolczyk, AJ; Pastan, I; Sampson, KE; Schimmer, B; Wong, M | 1 |
| Hirai, M; Hori, R; Kioka, N; Komano, T; Okamura, N; Tanigawara, Y; Ueda, K; Yasuhara, M | 1 |
| de Lannoy, IA; Silverman, M | 1 |
| Henderson, GB | 1 |
| Denisiuk, VI; Kotsuta, GI; Lipnitskiĭ, TN; Osiadlaia, ES; Pilipchuk, VP; Stepaniuk, AV | 1 |
| Hanano, M; Iga, T; Okudaira, K; Sawada, Y; Sugiyama, Y; Yamazaki, M | 1 |
| Fomina, IG; Iankin, VV | 1 |
| Hedman, A | 1 |
| Hohnloser, S; Just, H; Meinertz, T; Müller, B; Zehender, M | 1 |
| Denisiuk, VI; Kotsuta, GI; Lipnitskiĭ, TN; Stepaniuk, AV | 1 |
| Gottesman, MM; Horio, M; Lovelace, E; Pastan, I | 1 |
| DeCoursey, TE; Jacobs, ER | 1 |
| Ashavaid, TF; Colvin, RA; Katz, AM; Messineo, FC | 1 |
| Brooks, SM; Kulkarni, A; Richards, IS | 1 |
| Boesch, D; Loor, F; Muller, K; Pourtier-Manzanedo, A | 1 |
| Balashov, VP; Gendenshteĭn, EI; Kostin, IaV; Oleĭnikov, VE | 1 |
| Boucher, M; Dubray, C; Duchêne-Marullaz, P | 1 |
| DiCarlo, LA; Susser, F; Winston, SA | 1 |
| Mazur, NA; Shestakova, NV | 1 |
| Bando, S; Hamai, K; Nishikado, A; Shinohara, A; Yamamoto, H; Yamamoto, K | 1 |
| Singh, BN; Takanaka, C | 1 |
| Chen, CY; Liou, JY | 1 |
| Bedenne, L; Caillot, D; Chauffert, B; Corda, C; Martin, F; Pelletier, H; Solary, E | 1 |
| Arfiero, S; Ometto, R; Vincenzi, M | 1 |
| Hahn, EW; Osswald, H; Pommerenke, EW; Volm, M | 1 |
| Bazill, GW; Dexter, TM | 1 |
| Dankó, M; Lathrop, DA; Nánási, PP; Varró, A | 1 |
| Häussinger, D; Lang, F; Stehle, T | 1 |
| Eliason, JF; Kaufmann, F; Ramuz, H | 1 |
| Hagiwara, S; Schlichter, L; Sidell, N | 1 |
| Keefe, DL; Miura, D; Somberg, JC | 1 |
| Golub, SH; Hagiwara, S; Schlichter, LC; Sidell, N; Wright, SC | 1 |
| Cornwell, MM; Gottesman, MM; Pastan, I | 1 |
| Link, H; Mix, E; Olsson, T; Solders, G | 1 |
| Hoffmeister, HM; Krämer, B; Pflug, A; Seipel, L | 1 |
| Assaraf, YG; Molina, A; Schimke, RT | 1 |
| Bindslev, N; Demant, EJ; Friche, E; Jensen, PB; Sehested, M; Skovsgaard, T; Vindeløv, L | 1 |
| Aronow, WS | 1 |
| Cepeláková, H; Hapala, J; Smíd, J; Topinka, I; Topolcan, O; Vainer, J | 1 |
| Calvo, L; Maté, I; Mesa, JM; Moreno, I; Plaza, I; Rico, J; Sobrino, JA | 1 |
| Halawa, B; Mazurek, W | 1 |
| Müller, A; Noack, E | 1 |
| Antman, EM; Smith, TW | 1 |
| Somberg, J | 1 |
| Buday, G; Kerkovits, G; Palócz, E | 1 |
| Anderson, JL | 1 |
| Anderson, M; Fergusson, J; Warr, JR | 1 |
| Bayés de Luna, A; Guindo, J; Oter, MC | 1 |
| Chittolini, L; Cozzi, E; Ghiringhelli, S; Glisenti, F; Straneo, G; Straneo, U; Tsialtas, D | 1 |
| Insel, PA; Maisel, AS; Motulsky, HJ | 1 |
| Morganroth, J; Nestico, PF | 1 |
| Huang, SK; Marcus, FI | 1 |
| Chang, H; Kurokawa, K; Matsunaga, H; Yamashita, N | 1 |
| Riley, CM | 1 |
| Gottesman, MM; Horio, M; Pastan, I | 1 |
| Hricák, V; Kovácik, M | 1 |
| Bálint, Z; Szekeres, L; Tósaki, A | 1 |
| Gautam, CS; Lal, R; Pandhi, P; Sharma, PL | 1 |
| Greger, R; Lang, F; Völkl, H | 1 |
| Kuhlmann, J | 1 |
| Balazs, T; Ehrreich, SJ; el-Hage, AN; Johnson, GL | 1 |
| Kecskeméti, V; Kelemen, K; Kovács, G; Mészáros, J | 1 |
| Goldenberg, LM; Gordon, M | 1 |
| Cardarelli, CO; Cornwell, MM; Gottesman, MM; Pastan, I; Willingham, MC | 1 |
| Garson, A | 1 |
| Beckman, H; Blevins, R; Edwards, DJ; Lavoie, R; Rubenfire, M | 1 |
| Pedersen, KE | 1 |
| Somberg, JC | 2 |
| Anda, L; Eichelbaum, M; Greenblatt, DJ; Ochs, HR | 1 |
| Stewart, PA; Wladimiroff, JW | 1 |
| Hirosawa, K; Kasanuki, H; Onishi, S | 1 |
| Castellanos, A; Estes, DM; Kessler, KM; Myerburg, RJ; Palomo, AR; Trohman, RG | 1 |
| Gersh, BJ; Hammill, SC; Holmes, DR; Mair, DD; McLaran, C; Sugrue, DD | 1 |
| Koren, G | 1 |
| Riccioppo Neto, FR; Sperelakis, N | 1 |
| Dorph-Petersen, A | 1 |
| Schmidt-Voigt, J | 1 |
| Belz, GG; Olesch, K | 1 |
| Diedrich, R; Hardewig, A | 1 |
| Krikler, DM | 1 |
| Kaufmann, G | 1 |
| Chatillon, J | 1 |
| Hauswirth, O; Singh, BN | 1 |
| Thyrum, PT | 1 |
| Fratz, R; Greeff, K; Wagner, J | 2 |
| Heeg, E; Reuter, N; Steiger, H | 1 |
| Strubelt, O; Zetler, G | 1 |
| Balzer, H | 1 |
| Hanna, C; Schmid, JR | 2 |
| Fleckenstein, A; Fleckenstein, B; Herbst, A; Krause, H; Tritthart, H | 1 |
| Grodzińska, L | 1 |
| Hensel, G | 1 |
| Bleifeld, W; Effert, S; Merx, W | 1 |
| Heeg, E; Reuter, N | 1 |
| Belz, GG; Lang, D; von Bernuth, G | 1 |
| Collignon, P; Kulbertus, H | 1 |
| Bachour, G; Bender, F; Brisse, B; Gradaus, D; Heilmann, E | 1 |
| Boissier, JR; Giudicelli, JF; Larno, S; Witchitz, S | 1 |
| Reuter, N | 1 |
| Balassanian, S; Chutlian, A; De Soldati, L; Fabregas, R; Fuksman, A; Mario Krasnov, C; Rosental, R; Stritzler, G | 1 |
| Fischer, U; Haas, H; Raschack, M | 1 |
| Schollmeyer, P | 1 |
| Betz, GG; Olesch, K; Schmidt-Voigt, J | 1 |
| Haas, H; Igarashi, T | 1 |
| Büchner, M; Effert, S; Grosse-Brockhoff, F | 1 |
| Opie, LH | 2 |
| Aloisi, B; Brancati, B; Liistro, M; Mazzaglia, G; Negro, R; Russo, L | 1 |
| Peters, RW | 1 |
| DiBianco, R; Fletcher, RD; Gottdiener, JS | 1 |
| Attuel, P; Coumel, P; Georgiopoulos, G; Halkidis, H; Leclercq, JF; Maisonblanche, P | 1 |
| Belleau, B; Benfey, BG; Melchiorre, C; Montambault, M | 1 |
| Elkayam, U; Frishman, W; Rotmensch, HH | 1 |
| Hillis, WS; Whiting, B | 1 |
| Prystowsky, EN | 1 |
| Runge, M | 1 |
| Dunlap, DB; Willoughby, ML | 1 |
| Jahrmärker, H; Theisen, K | 1 |
| Attuel, P; Bouvrain, Y; Coumel, P; Leclercq, JF; Milosevic, D; Rosengarten, M; Slama, R | 1 |
| Bramann, HU; Brisse, B; Gülker, H; Kuhs, H | 1 |
| Bender, F; Gülker, H; Heuer, H; Thale, J | 1 |
| Jancke, T | 1 |
| Philipp, H | 1 |
| von Bock, U | 1 |
| Motté, G | 1 |
| Butler, B; Keren, G; Somberg, JC; Tepper, D; Torres, V | 1 |
| Rosen, MR; Wit, AL | 1 |
| Koren, G; MacLeod, SM | 1 |
| Curtis, MJ; MacLeod, BA; Walker, MJ | 1 |
| Halawa, B | 2 |
| Scheininger, M; Theisen, K | 1 |
| Doering, W | 1 |
| Koren, G; MacLeod, SM; Soldin, S | 1 |
| Bendeer, F; Gülker, H; Heuer, H; Meyer, M; Thale, J; Weiss, U | 1 |
| Brokl, OH; Dantzler, WH | 1 |
| Golitsyn, SP; Grosu, AA; Smetnev, AS; Sokolov, SF | 1 |
| Taylor, A | 1 |
| Beck, OA; Günther, R; Hochrein, H | 2 |
| Grishkin, IuN; Uzilevskaia, RA | 1 |
| Zeng, GY | 1 |
| Fleischmann, DW | 1 |
| Dreifus, LS; Morganroth, J | 1 |
| Fausa, D; Rasmussen, K; Wang, H | 1 |
| Lukoshevichiute, AI; Reĭngardene, DI | 1 |
| Epstein, SE; Rosing, DR | 1 |
| Hasin, Y; Rogel, S; Sarel, O | 1 |
| Gleichmann, U; Kleinebenne, A; Mannebach, H | 1 |
| Campbell, RW | 1 |
| Bertoni, PD; Di Michele, R; Tosetto, C | 1 |
| Castellanos, A; Styperek, JL; Sung, RJ | 1 |
| Bisaglia, RE; Fagundes, ML | 1 |
| Kirikova, LT; Kostin, VI; Nesterov, IuI; Raevskaia, LG | 1 |
| Dhein, S; Gottwald, E; Klaus, W; Schott, M | 1 |
| Benz, I; Kohlhardt, M | 1 |
| Boucher, M; Chapuy, E; Chassaing, C; Duchêne-Marullaz, P | 1 |
| Katina, IE; Luk'ianenko, VI; Nasledov, GA | 1 |
| Bachernegg, M; Decrinis, M; Domanowits, H; Kickenweiz, E; Laggner, AN; Stark, G; Stark, U; Sterz, F; Tritthart, HA | 1 |
| Consolo, A; Oreto, G; Pulitanò, G; Scimone, IM | 1 |
| Banitt, P; Creager, MA; Lipson, DE; Rongen, GA; Smits, P; Williams, SB | 1 |
| Ishii, K; Taira, N; Yamagishi, T | 1 |
| Bagnasco, S; Barone, V; Galietta, LJ; Rasola, A; Romeo, G | 1 |
| Cook, DI; Hayashi, T; Hirono, C; Young, JA | 1 |
| Imanishi, S; Miyamae, S | 1 |
| Cook, DI; Ishikawa, T | 1 |
| Gottesman, MM; Mickisch, GH; Pastan, I | 1 |
| Just, H; Meinertz, T; Zehender, M | 1 |
| Betz, P; Kalusche, D; Roskamm, H; Stockinger, J | 1 |
| Aksentijevich, I; Cardarelli, CO; Gottesman, MM; Pastan, I | 1 |
| Choe, KJ; Gottesman, MM; Hong, IG; Kim, HS; Kim, WH; Kim, YI; Lee, SK; Lim, KH; Park, JG; Tsuruo, T | 1 |
| Aronson, R; Ming, Z; Nordin, C | 1 |
| Aiba, T; Hori, R; Okamura, N; Tanigawara, Y | 1 |
| Futai, M; Manabe, T; Moriyama, Y; Tashiro, Y; Yoshimori, T | 1 |
| Lüderitz, B; Manz, M | 1 |
| Raderer, M; Scheithauer, W | 1 |
| Hill, BT; Hosking, LK | 1 |
| Bicknell, SR; Hamilton, T; Kaye, SB; Morrison, JG; Plumb, JA; Setanoians, A; Wishart, GC | 1 |
| Katina, IE; Lukyanenko, V; Nasledov, GA; Terentyev, DA | 1 |
| Gautam, CS; Pandhi, P; Sharma, PL | 1 |
| Bauer, LA; Horn, JR; Pettit, H | 1 |
| Algour, N; Ayesh, S; Lyubimov, E; Stein, WD | 1 |
| Dillon, EC; Innes, GD; Metcalfe, C; Vertesi, L | 1 |
| Pfitzner, P; Trappe, HJ | 1 |
| Karch, M; Plewan, A; Schmidt, G; Schmitt, C; Schömig, A | 1 |
| Baughman, TM; Bell, MG; Cao, J; Dantzig, AH; Ehlhardt, WJ; Elmquist, WF; Gruber, J; Kroin, JS; Law, KL; Norman, BH; Shepard, RL; Shih, C; Starling, JJ; Winter, MA | 1 |
| Ito, S; Koren, G; Woodland, C | 1 |
| Hedman, A; Meijer, DK | 2 |
| Foglar, R; Hirasawa, A; Ogawa, S; Shibata, K; Tsujimoto, G | 1 |
| Chugun, A; Hara, Y; Kondo, H; Nakaya, H | 1 |
| Cohn, D; DeLuna, P; Gorham, LM; Leung, K; Lin, JH; Ma, B; Pang, J; Prueksaritanont, T; Xu, X | 1 |
| Lay, RH; Medh, RD; Schmidt, TJ | 1 |
| D'Andrea, A; Ducceschi, V; Iacono, A; Liccardo, B; Santangelo, L; Sarubbi, B | 1 |
| Boucher, M; Chapuy, E; Chassaing, C; Lorente, P | 1 |
| Clauss, W; Heinke, B | 1 |
| Koch, HP; Lüderitz, B; Meinertz, T; Patten, M; Sonntag, F | 1 |
| Breithardt, G; Burschel, G; Engberding, R; Fetsch, T; Koch, HP; Lukl, J; Trappe, HJ; Treese, N | 1 |
| Barthe, L; Bouër, R; Houin, G; Philibert, C; Tournaire, C; Woodley, J | 1 |
| Aguilar, AJ; Grace, JM; Skanchy, DJ | 1 |
| Feng, JL; Nattel, S; Wang, Z; Yue, L | 1 |
| Cattarini, G; Mazzone, C; Miccio, M; Morgera, T; Pandullo, C; Salvi, R; Scardi, S | 1 |
| Dell'Orfano, JT; Luck, JC; Naccarelli, GV; Patel, HM; Wolbrette, DL | 1 |
| Doebler, JA | 1 |
| Baluom, M; Friedman, M; Rubinstein, A | 1 |
| Bergø, GW; Risberg, J; Stuhr, LE; Tyssebotn, I | 1 |
| Benet, LZ; Lantz, MV; Parasrampuria, DA | 1 |
| Bible, KC; Boerner, SA; Kaufmann, SH; Tourne, ME | 1 |
| Armstrong, JD; Kaiser, K; Rosay, P; Wang, Z | 1 |
| Cooper, RA; Ferdig, MT; Fidock, DA; Fujioka, H; Mu, J; Nomura, T; Roepe, PD; Su, XZ; Ursos, LM; Wellems, TE | 1 |
| Fetsch, T | 1 |
| Cook, A; Franks, CJ; Holden-Dye, L; Pemberton, D; Vinogradova, I; Walker, RJ | 1 |
| Alvarez, AI; Kim, RB; Merino, G; Prieto, JG | 1 |
| Plass, H; Turnheim, K; Wyskovsky, W | 1 |
| Pollack, GM; Zong, J | 1 |
| Axelsson, H; Floby, E; Granhall, C; Jaksch, Y; Sohlenius-Sternbeck, AK; Svedling, M | 1 |
| Ben-Zvi, Z; Holcberg, G; Huleihel, M; Katz, M; Lazer, S; Mazor, M; Sapir, O; Tsadkin, M | 1 |
| HUQ, S; MELVILLE, KI; SHISTER, HE | 1 |
| Dagenais, C; Graff, CL; Pollack, GM | 1 |
| Duvvuri, S; Gandhi, MD; Mitra, AK | 1 |
| Binder, G; Chang, LF; Davis, BM; Dropulic, B; Humeau, L; Korshalla, L; Lu, X; Ni, Y; Ogunjimi, EO; Slepushkin, V | 1 |
| O'Donnell, MJ; Rheault, MR | 1 |
| Bauer, P; Breithardt, G; Engberding, R; Fetsch, T; Koch, HP; Lukl, J; Meinertz, T; Oeff, M; Seipel, L; Trappe, HJ; Treese, N | 1 |
| Bauer, P; Dluzniewski, M; Hatala, R; Lüderitz, B; Maas, R; Meinertz, T; Müller, HW; Opolski, G; Patten, M; Sonntag, F | 1 |
| Cisternino, S; Debray, M; Rousselle, C; Scherrmann, JM | 1 |
| Annaert, PP; Brouwer, KL | 1 |
| Fukami, T; Furuishi, T; Moriki, Y; Suzuki, T; Tomono, K; Watanabe, J | 1 |
| de Paola, AA; Veloso, HH | 1 |
| Antz, M; Kuck, KH; Nitschmann, S | 1 |
| Chan, K; Jiang, ZH; Liu, L; Liu, ZQ; Wong, YF; Xu, HX; Zhou, H | 1 |
| Panchagnula, R; Varma, MV | 1 |
| Balimane, P; Kadiyala, P; Olah, T; Smalley, J; Xin, B | 1 |
| Dorani, H; Eriksson, UG; Fritsch, H; Hoffmann, KJ; Karlsson, J; Olsson, L; Sarich, TC; Schützer, KM; Wall, U | 1 |
| Amat di San Filippo, C; Longo, N; Pasquali, M | 1 |
| Hamlin, RL; Keene, BW; Kijtawornrat, A; Nishijima, Y; Roche, BM | 1 |
| Chiou, WL; Yao, HM | 1 |
| Bruesewitz, C; Funke, A; Kuhland, U; Lipp, R; Wagner, T | 1 |
| Karim, A; Maas, R; Meinertz, T; Müller, HW; Patten, M; Simonovsky, R | 1 |
| Kawasaki, M; Langguth, P; Moriya, Y; Nakamura, T; Okumura, K; Omatsu, H; Sakaeda, T; Sakane, T; Shirasaka, Y; Yamashita, S | 1 |
| Asashi, S; Higuchi, T; Katoh, M; Suzuyama, N; Takeuchi, T; Yokoi, T; Yoshitomi, S | 1 |
| Croft, SL; Mansor, SM; Nair, NK; Navaratnam, V; Ramanathan, S; Sattar, MA; Venkatesh, G | 1 |
| Bermejo, M; Casabó-Alós, VG; Fernández-Teruel, C; Garrigues, TM; González-Alvarez, I; Polli, JE; Ruiz-García, A | 1 |
| Chen, X; Chowbay, B; Duan, W; Li, CG; Liang, J; Lin, SG; Liu, PQ; Wen, JY; Yu, XY; Zhou, SF; Zhou, ZW | 1 |
| Cao, J; Chan, E; Chen, X; Chowbay, B; Duan, W; Li, CG; Li, XT; Liang, J; Lin, SG; Wen, JY; Xue, CC; Yu, XQ; Yu, XY; Zhou, SF; Zhou, ZW | 1 |
| Chen, X; Li, XX; Xue, CC; Zhou, SF; Zhou, ZW | 1 |
| Heikkinen, AT; Mönkkönen, J | 1 |
| Bui, T; Ho, RJ; Hsiao, P; Unadkat, JD | 1 |
| Li, B; Ma, Y; Pu, J; Quan, X; Zhang, C; Zhao, G | 1 |
| Kataoka, M; Masaoka, Y; Sakuma, S; Shirasaka, Y; Yamashita, S | 1 |
| Berkowitsch, A; Erkapic, D; Hamm, CW; Kuniss, M; Neumann, T; Pitschner, HF; Schmitt, J; Sperzel, J | 1 |
| Hashimoto, M; Kagota, S; Kunitomo, M; Nakamura, K; Nejime, N; Shinozuka, K; Tada, Y | 1 |
| Amidon, GL; Dahan, A | 1 |
| Hippalgaonkar, K; Majumdar, S; Srirangam, R | 1 |
| Pollack, GM; Zhao, R | 1 |
| Anzai, N; Endou, H; Jutabha, P; Kadota, T; Otomo, J; Wempe, MF | 1 |
| Kato, M; Kitamura, S; Mitsui, T; Shirasaka, Y; Sugiyama, Y; Tachibana, T; Yamashita, S | 1 |
| Bonnemeier, H; Hescheler, J; Liang, H; Matzkies, M; Reppel, M; Schunkert, H; Tang, M | 1 |
| Avula, B; Hippalgaonkar, K; Khan, IA; Majumdar, S; Srirangam, R | 1 |
| Kawazu, K; Kiuchi, Y; Miyazaki, T; Oyabu, M; Toda, R | 1 |
| Fujita, T; Ikeda, Y; Kumagai, Y; Maeda, K; Nozawa, K; Oyama, Y; Sugiyama, Y; Takano, J | 1 |
| Kataoka, M; Masaoka, Y; Sakuma, S; Yamashita, S; Yokoyama, T | 1 |
| Be, X; Berry, L; Chen, A; Huang, L; Janosky, B; Lin, MH; Roberts, J | 1 |
| Barabach, S; Feusette, P; Kukla, P; Sacha, J | 1 |
| Amad, M; Batonga, J; Bethell, RC; Bolger, G; Cordingley, MG; Duan, J; Garneau, M; Jutras, M; Kukolj, G; Lapeyre, N; Montpetit, H; Otis, F; Rhéaume, M; White, PW | 1 |
| Mehta, A; Ooi, TH; Sequiera, GL; Shim, W | 1 |
| Dong, QX; Gao, JM; He, JH; Huang, CJ; Li, CQ; Xu, YQ; Xuan, YX; Yu, HP; Zhu, JJ | 1 |
| Han, HK; Kang, KW; Lee, MY; Lee, YJ; Oh, SJ | 1 |
| Alvarenga, ES; Ferreira-Pereira, A; Figueira-Mansur, J; Franco, TA; Leal, WS; Mansur, JF; Masuda, H; Melo, AC; Moreira, MF; Neves, BC; Sorgine, MH | 1 |
| Hu, ZY; Zhao, Y | 1 |
| Fujii, S; Hosoya, K; Kawazu, K; Setoguchi, C | 1 |
| Florian, J; Galeotti, L; Guo, P; Hong, M; Johannesen, L; Lin, J; Mason, JW; Sanabria, C; Stockbridge, N; Strauss, DG; Sørensen, JS; Ugander, M; Vicente, J; Waite-Labott, K | 1 |
| Haigney, MC | 1 |
| Bellanca, S; Dave, A; Dittmer, M; Lanzer, M; Martin, RE; Meyrath, M; Nash, MN; Sanchez, CP; Stein, WD; Summers, RL | 1 |
| Fukami, T; Suzuki, T; Tomono, K | 1 |
| Crumb, WJ; Johannesen, L; Mason, JW; Pueyo, E; Stockbridge, N; Strauss, DG; Vicente, J | 1 |
| de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M | 1 |
| Bernkop-Schnürch, A; Laffleur, F; Netsomboon, K; Suchaoin, W | 1 |
| de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M; Siissalo, S; van Dam, A | 1 |
| Braun, F; Danker, T; Guenther, E; Silbernagl, N | 1 |
| Akazawa, T; Ohtsuki, S; Tachikawa, M; Terasaki, T; Uchida, Y | 1 |
| de Graaf, IA; de Jager, MH; Groothuis, GM; Li, M; van de Steeg, E | 1 |
| Jung, JA; Parvez, MM; Shin, HJ; Shin, JG | 1 |
| Bergenholm, L; Chappell, MJ; Collins, T; Evans, ND; Mettetal, J; Parkinson, J | 1 |
| Jadhav, G; Mukkavilli, R; Vangala, S | 1 |
| Hinoi, E; Miyawaki, I; Tsubouchi, T; Watanabe, K; Yamada, T | 1 |
| Marathe, P; Rodrigues, AD; Shen, H; Sinz, M; Yao, M; Zhu, M | 1 |
| Choi, M; Choi, YW; Jeong, YJ; Kim, DS; Kim, ES; Lee, DW; Oyunbaatar, NE; Park, J; Shanmugasundaram, A | 1 |
| Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N | 1 |
| Bai, S; Cao, H; Chen, K; Dong, H; Ma, Y; Pei, J; Tian, L; Zhao, Y | 1 |
| De Zwart, L; Evers, R; Yamazaki, S | 1 |
| Kawai, T; Kuninishi, Y; Muraki, Y; Nogawa, H | 1 |
| Christini, DJ; Clark, AP; Kalola, D; Krogh-Madsen, T; Wei, S | 1 |
| Jeong, YJ; Kanade, PP; Kim, ES; Lee, BK; Lee, DW; Oyunbaatar, NE; Shanmugasundaram, A | 1 |
| Bove, T; Cilenti, F; Copetti, R; Cristiani, L; Guglielmo, N; Orso, D; Santangelo, S | 1 |
36 review(s) available for verapamil and quinidine
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
Topics: Animals; Biogenic Amines; Humans; Plasma Membrane Neurotransmitter Transport Proteins; Xenobiotics | 2016 |
Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship | 2017 |
Cardiac arrhythmias - a short review.
Topics: Adrenergic beta-Agonists; Arrhythmias, Cardiac; Digitalis Glycosides; Electric Countershock; Electrocardiography; Humans; Lidocaine; Mexiletine; Pacemaker, Artificial; Phenytoin; Procainamide; Quinidine; Verapamil | 1976 |
Limitations of present drug therapy of cardiac arrhythmias--a review.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Humans; Lidocaine; Procainamide; Quinidine; Verapamil | 1977 |
Papaverine as an antiarrhythmic agent.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Papaverine; Procainamide; Quinidine; Structure-Activity Relationship; Verapamil | 1977 |
[Mechanisms of interactions of anti-arrhythmia agents during their combined use].
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Potassium; Procainamide; Propranolol; Quinidine; Verapamil | 1991 |
The treatment of ventricular rhythm disturbances.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Disopyramide; Electric Countershock; Electric Stimulation; Electrocardiography; Exercise Test; Flecainide; Heart Ventricles; Humans; Lidocaine; Phenytoin; Piperidines; Procainamide; Quinidine; Risk; Tachycardia; Tocainide; United States; Ventricular Fibrillation; Verapamil | 1986 |
Management of supraventricular tachyarrhythmias.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Bradycardia; Humans; Procainamide; Propranolol; Quinidine; Sick Sinus Syndrome; Tachycardia, Supraventricular; Verapamil | 1989 |
Digitalis toxicity.
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Biological Availability; Carotid Sinus; Digitalis Glycosides; Drug Interactions; Electric Countershock; Heart; Heart Conduction System; Humans; Kinetics; Lidocaine; Parasympathetic Nervous System; Phenytoin; Potassium; Procainamide; Quinidine; Sympathetic Nervous System; Verapamil | 1985 |
Antiarrhythmic drug therapy. Recent advances and current status.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil | 1985 |
Rationale of combination antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Digitalis Glycosides; Drug Therapy, Combination; Humans; Mexiletine; Myocardial Infarction; Quinidine; Tachycardia; Verapamil | 1985 |
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment.
Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil | 1986 |
Antiarrhythmic drug therapy of ventricular arrhythmias.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil | 1986 |
[Anti-arrhythmia agents].
Topics: Action Potentials; Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Cardiac Complexes, Premature; Heart; Heart Conduction System; Humans; Lidocaine; Phenytoin; Practolol; Procainamide; Quinidine; Sparteine; Ventricular Fibrillation; Verapamil | 1974 |
Comparative mechanisms of action of antiarrhythmic drugs.
Topics: Action Potentials; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans; Benzyl Compounds; Bretylium Compounds; Calcium; Carbamazepine; Chemical Phenomena; Chemistry; Diethylamines; Disopyramide; Heart; Humans; Imidazoles; Iodobenzoates; Lidocaine; Membrane Potentials; Phenyl Ethers; Phenytoin; Procainamide; Propylamines; Quinidine; Verapamil | 1974 |
[Modern treatment of cardiac arrhythmias].
Topics: Adrenergic beta-Antagonists; Arrhythmias, Cardiac; Bradycardia; Cell Membrane Permeability; Digitalis Glycosides; Electric Countershock; Heart; Heart Block; Humans; Hypoxia; Magnesium; Metaproterenol; Myocardium; Pacemaker, Artificial; Phenytoin; Phytotherapy; Plants, Medicinal; Potassium; Quinidine; Rauwolfia; Sodium; Sparteine; Tachycardia; Ventricular Fibrillation; Verapamil | 1971 |
Effects of antiarrhythmic agents on cardiac function.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Dogs; Encainide; Hemodynamics; Humans; Myocardial Contraction; Quinidine; Verapamil | 1982 |
Antiarrhythmic drug therapy during pregnancy.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Breast Feeding; Digitalis Glycosides; Disopyramide; Female; Fetus; Humans; Infant, Newborn; Lidocaine; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Pregnancy Complications, Cardiovascular; Procainamide; Quinidine; Tachycardia; Verapamil | 1983 |
Pharmacologic therapy of tachyarrhythmias in patients with Wolff-Parkinson-White syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Ajmaline; Amiodarone; Anilides; Aprindine; Atrial Fibrillation; Benzofurans; Digitalis Glycosides; Disopyramide; Encainide; Female; Humans; Lidocaine; Male; Middle Aged; Procainamide; Quinidine; Tachycardia; Verapamil; Wolff-Parkinson-White Syndrome | 1983 |
[Therapy of arrhythmia during pregnancy].
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biotransformation; Coumarins; Digoxin; Drug Synergism; Female; Fetal Growth Retardation; Fetus; Heparin; Humans; Infant, Newborn; Milk, Human; Pacemaker, Artificial; Pregnancy; Pregnancy Complications, Cardiovascular; Procainamide; Quinidine; Verapamil | 1984 |
The treatment of atrial fibrillation and flutter: a review.
Topics: Adrenergic beta-Antagonists; Anticoagulants; Atrial Fibrillation; Atrial Flutter; Cardiac Pacing, Artificial; Digitalis Glycosides; Electric Countershock; Embolism; Humans; Procainamide; Quinidine; Verapamil | 1984 |
[Medical treatment of extrasystole and tachycardia (author's transl)].
Topics: Action Potentials; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Bretylium Compounds; Calcium; Cardiac Complexes, Premature; Digoxin; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Verapamil | 1980 |
Physiology and pharmacology of antiarrhythmic drugs.
Topics: Action Potentials; Anti-Arrhythmia Agents; Cell Membrane; Heart Conduction System; Humans; Ion Channels; Kinetics; Lidocaine; Membrane Potentials; Myocardium; Quinidine; Verapamil | 1981 |
Electropharmacology of antiarrhythmic drugs.
Topics: Action Potentials; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disopyramide; Electric Conductivity; Heart Atria; Heart Ventricles; Humans; Lidocaine; Membrane Potentials; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Procainamide; Propranolol; Purkinje Fibers; Quinidine; Tocainide; Verapamil | 1983 |
Role of cytosolic calcium and sodium-calcium exchange in regulation of transepithelial sodium and water absorption.
Topics: Animals; Biological Transport, Active; Body Water; Calcimycin; Calcium; Cytosol; Epithelium; Kidney; Lasalocid; Membrane Potentials; Necturus; Quinidine; Sodium; Verapamil | 1981 |
Antiarrhythmic agents and their use in therapy.
Topics: Acebutolol; Animals; Anti-Arrhythmia Agents; Digitalis Glycosides; Disopyramide; Humans; Lidocaine; Oxytocin; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil | 1980 |
[Value of drug tests in Wolff-Parkinson-White syndrome].
Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrioventricular Node; Diagnosis, Differential; Electrocardiography; Humans; Lidocaine; Myocardial Infarction; Procainamide; Quinidine; Verapamil; Wolff-Parkinson-White Syndrome | 1981 |
In vivo models of P-glycoprotein-mediated multidrug resistance.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clone Cells; Cloning, Molecular; Cyclosporine; Drug Resistance, Multiple; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental; Quinidine; Recombinant Fusion Proteins; Reproducibility of Results; Research Design; Sensitivity and Specificity; Transplantation, Heterologous; Tumor Cells, Cultured; Verapamil | 1994 |
Supraventricular tachycardia and pre-excitation syndromes: pharmacological therapy.
Topics: Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Disopyramide; Flecainide; Humans; Imidazoles; Pre-Excitation Syndromes; Propafenone; Quinidine; Sotalol; Tachycardia, Paroxysmal; Tachycardia, Supraventricular; Verapamil | 1993 |
Clinical trials of agents that reverse multidrug resistance. A literature review.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Clinical Trials as Topic; Cyclosporins; Drug Resistance; Humans; Phenotype; Quinidine; Tamoxifen; Trifluoperazine; Verapamil | 1993 |
Toxic digoxin-drug interactions: the major role of renal P-glycoprotein.
Topics: Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporine; Digoxin; Drug Interactions; Glomerular Filtration Rate; Humans; Itraconazole; Kidney Tubules; Quinidine; Verapamil | 1998 |
Atrial fibrillation: what are the effects of drug therapy on the effectiveness and complications of electrical cardioversion?
Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Digoxin; Electric Countershock; Flecainide; Humans; Procainamide; Quinidine; Verapamil | 1998 |
Cost-effective management of acute atrial fibrillation: role of rate control, spontaneous conversion, medical and direct current cardioversion, transesophageal echocardiography, and antiembolic therapy.
Topics: Algorithms; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Cost-Benefit Analysis; Echocardiography, Transesophageal; Electric Countershock; Flecainide; Humans; Procainamide; Propafenone; Quinidine; Sotalol; Verapamil | 2000 |
Bayesian Network Meta-analysis of Randomized Controlled Trials on the Efficacy of Antiarrhythmics in the Pharmacological Cardioversion of Paroxysmal Atrial Fibrillation.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Electric Countershock; Flecainide; Humans; Network Meta-Analysis; Quinidine; Randomized Controlled Trials as Topic; Ranolazine; Systematic Reviews as Topic; Verapamil | 2023 |
27 trial(s) available for verapamil and quinidine
| Article | Year |
|---|---|
[Prospective course of therapy arresting attacks of atrial fibrillation in patients with preexcitation syndromes].
Topics: Adult; Aged; Aged, 80 and over; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Disopyramide; Female; Humans; Male; Mexiletine; Middle Aged; Moricizine; Pre-Excitation Syndromes; Procainamide; Propranolol; Quinidine; Time Factors; Verapamil | 1992 |
Effects of amiodarone versus quinidine and verapamil in patients with chronic atrial fibrillation: results of a comparative study and a 2-year follow-up.
Topics: Amiodarone; Atrial Fibrillation; Chronic Disease; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Heart Diseases; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Treatment Outcome; Verapamil | 1992 |
[Verapamil in combination therapy].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Calcium Channel Blockers; Clinical Trials as Topic; Digitalis Glycosides; Drug Evaluation; Drug Therapy, Combination; Female; Heart Diseases; Humans; Isosorbide; Male; Middle Aged; Quinidine; Verapamil | 1985 |
Interatrial conduction block with retrograde activation of the left atrium and paroxysmal supraventricular tachyarrhythmias: influence of preventive antiarrhythmic treatment.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Electrocardiography; Female; Follow-Up Studies; Heart Atria; Heart Block; Humans; Male; Middle Aged; Quinidine; Tachycardia, Supraventricular; Verapamil | 1989 |
The effect of coadministration of verapamil on the pharmacokinetics and metabolism of quinidine.
Topics: Adult; Analysis of Variance; Drug Administration Schedule; Drug Interactions; Half-Life; Humans; Kinetics; Male; Quinidine; Random Allocation; Verapamil | 1987 |
Diltiazem, verapamil, and quinidine in patients with chronic atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Benzazepines; Chronic Disease; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Female; Humans; Male; Middle Aged; Quinidine; Random Allocation; Verapamil | 1985 |
[Therapy of ventricular extrasystoles with Cordichin].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Clinical Trials as Topic; Drug Combinations; Female; Heart Ventricles; Humans; Male; Middle Aged; Quinidine; Verapamil | 1982 |
Effect of coadministration of verapamil and quinidine on serum digoxin concentration.
Topics: Adult; Digoxin; Drug Combinations; Drug Interactions; Electrocardiography; Heart Rate; Humans; Middle Aged; Quinidine; Verapamil | 1983 |
Clinical uses of calcium ion antagonists in arrhythmias.
Topics: Adult; Aged; Alprenolol; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Child, Preschool; Clinical Trials as Topic; Female; Gallopamil; Humans; Male; Propylamines; Quinidine; Tachycardia, Paroxysmal; Tiapamil Hydrochloride; Verapamil | 1980 |
Comparative efficiency of quinidine and verapamil in the maintenance of sinus rhythm after DC conversion of atrial fibrillation. A controlled clinical trial.
Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Clinical Trials as Topic; Electric Stimulation Therapy; Humans; Quinidine; Random Allocation; Verapamil | 1981 |
[Conversion of chronic atrial fibrillation or flutter with disopyramide and a verapamil-quinidine combination: a comparative study ].
Topics: Aged; Atrial Flutter; Disopyramide; Drug Combinations; Female; Humans; Male; Middle Aged; Pyridines; Quinidine; Verapamil | 1982 |
Action of ATP on ventricular automaticity.
Topics: Adenosine Triphosphate; Adrenergic beta-Antagonists; Ajmaline; Animals; Anti-Arrhythmia Agents; Austria; Cardiac Pacing, Artificial; Drug Interactions; Emergency Medical Services; Female; Guinea Pigs; Heart Ventricles; Humans; Injections, Intravenous; Male; Propafenone; Prospective Studies; Quinidine; Tachycardia, Supraventricular; Ventricular Function; Verapamil | 1994 |
[Amiodarone and verapamil/quinidine in treatment of patients with chronic atrial fibrillation].
Topics: Aged; Amiodarone; Atrial Fibrillation; Chronic Disease; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Humans; Long-Term Care; Male; Middle Aged; Prospective Studies; Quinidine; Treatment Outcome; Verapamil | 1994 |
[Sotalol and quinidine/verapamil (Cordichin) in chronic atrial fibrillation--conversion and 12-month follow-up--a randomized comparison].
Topics: Aged; Atrial Fibrillation; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Electric Countershock; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Humans; Long-Term Care; Male; Middle Aged; Quinidine; Sotalol; Verapamil | 1994 |
[Urban & Vogel Workshop. Atrial fibrillation--decision aids for ambulatory therapy].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Double-Blind Method; Drug Combinations; Drug Therapy, Combination; Electric Countershock; Electrocardiography, Ambulatory; Female; Heart Conduction System; Humans; Male; Middle Aged; Pacemaker, Artificial; Quinidine; Sick Sinus Syndrome; Verapamil | 1995 |
Mixed-effect modeling for detection and evaluation of drug interactions: digoxin-quinidine and digoxin-verapamil combinations.
Topics: Adult; Aged; Aged, 80 and over; Aging; Anti-Arrhythmia Agents; Body Weight; Calcium Channel Blockers; Computer Simulation; Creatinine; Digoxin; Drug Combinations; Drug Interactions; Female; Humans; Male; Middle Aged; Models, Biological; Quinidine; Regression Analysis; Verapamil | 1996 |
Effectiveness of verapamil-quinidine versus digoxin-quinidine in the emergency department treatment of paroxysmal atrial fibrillation.
Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Double-Blind Method; Drug Therapy, Combination; Emergency Medical Services; Emergency Service, Hospital; Female; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Tachycardia, Paroxysmal; Treatment Outcome; Verapamil | 1997 |
[Medicamentous prevention of symptomatic paroxysmal atrial fibrillation/flutter onset. Goals and design of the SOPAT Study. Executive committee of the investigators representing trial physicians].
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Combinations; Electric Countershock; Electrocardiography, Ambulatory; Germany; Humans; Prospective Studies; Quinidine; Recurrence; Sotalol; Tachycardia, Paroxysmal; Telemetry; Treatment Outcome; Verapamil | 1999 |
[Medicamentous prevention after electric cardioversion of chronic atrial fibrillation. Goals and design of the PAFAC Study].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Chronic Disease; Czech Republic; Double-Blind Method; Drug Combinations; Electric Countershock; Electrocardiography, Ambulatory; Female; Germany; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Sotalol; Telemetry; Verapamil | 1999 |
Left atrial and appendage mechanical function after pharmacological or electrical cardioversion in patients with chronic atrial fibrillation: a multicenter, randomized study.
Topics: Aged; Anti-Arrhythmia Agents; Atrial Appendage; Atrial Fibrillation; Atrial Function, Left; Blood Flow Velocity; Chronic Disease; Echocardiography; Echocardiography, Doppler; Echocardiography, Transesophageal; Electric Countershock; Female; Humans; Male; Middle Aged; Quinidine; Verapamil | 2000 |
Prevention of atrial fibrillation after cardioversion: results of the PAFAC trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Double-Blind Method; Drug Therapy, Combination; Electric Countershock; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Secondary Prevention; Sotalol; Survival Analysis; Treatment Outcome; Verapamil | 2004 |
Suppression of paroxysmal atrial tachyarrhythmias--results of the SOPAT trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Drug Therapy, Combination; Electrocardiography; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Sotalol; Survival Analysis; Tachycardia; Treatment Outcome; Verapamil | 2004 |
Event-recorder monitoring in the diagnosis of atrial fibrillation in symptomatic patients: subanalysis of the SOPAT trial.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Electrocardiography; Electrocardiography, Ambulatory; Humans; Quinidine; Randomized Controlled Trials as Topic; Verapamil | 2006 |
Nonlinear pharmacokinetics of oral quinidine and verapamil in healthy subjects: a clinical microdosing study.
Topics: Administration, Oral; Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Humans; Intestine, Small; Male; Quinidine; Verapamil; Young Adult | 2011 |
Differentiating drug-induced multichannel block on the electrocardiogram: randomized study of dofetilide, quinidine, ranolazine, and verapamil.
Topics: Acetanilides; Calcium Channel Blockers; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Heart Rate; Humans; Phenethylamines; Piperazines; Potassium Channel Blockers; Prospective Studies; Quinidine; Ranolazine; Sodium Channel Blockers; Sulfonamides; Verapamil | 2014 |
Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil.
Topics: Adult; Calcium Channel Blockers; Cross-Over Studies; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; Humans; Long QT Syndrome; Male; Phenethylamines; Quinidine; Ranolazine; Sodium Channel Blockers; Sulfonamides; Verapamil | 2015 |
Predicting QRS and PR interval prolongations in humans using nonclinical data.
Topics: Animals; Anti-Arrhythmia Agents; Azabicyclo Compounds; Carbamates; Dogs; Drug Evaluation, Preclinical; Electrocardiography; Flecainide; Guinea Pigs; Heart; Heart Rate; Humans; Long QT Syndrome; Male; Models, Biological; Quinidine; Verapamil | 2017 |
357 other study(ies) available for verapamil and quinidine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Chemistry, pharmacology, and structure-activity relationships with a new type of imidazolines exerting a specific bradycardic action at a cardiac site.
Topics: Animals; Chemical Phenomena; Chemistry; Chemistry, Physical; Female; Guinea Pigs; Heart Rate; Imidazoles; Male; Myocardial Contraction; Rats; Structure-Activity Relationship | 1980 |
Bicinchoninic acid protein assay in the determination of adriamycin cytotoxicity modulated by the MDR glycoprotein.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Copper; Doxorubicin; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Fluorometry; Humans; Indicators and Reagents; Quality Control; Quinolines; Tumor Cells, Cultured | 1996 |
Cloning and functional expression of a human liver organic cation transporter.
Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Liver; Membrane Proteins; Molecular Sequence Data; Oocytes; Organic Cation Transporter 1; Polymerase Chain Reaction; Rats; RNA, Messenger; Sequence Homology, Amino Acid; Species Specificity; Tissue Distribution; Xenopus laevis | 1997 |
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine.
Topics: Animals; Anion Transport Proteins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Carrier Proteins; Genes, MDR; HeLa Cells; Histamine H1 Antagonists; Humans; LLC-PK1 Cells; Mice; Rats; Swine; Terfenadine; Tissue Distribution; Transfection; Vaccinia virus | 1999 |
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
Topics: Biological Transport, Active; Carnitine; Carrier Proteins; Cations; Cells, Cultured; Dose-Response Relationship, Drug; Embryo, Mammalian; Humans; Hydrogen-Ion Concentration; Kidney; Membrane Proteins; Organic Cation Transport Proteins; Sodium; Solute Carrier Family 22 Member 5; Stereoisomerism | 1999 |
Pharmacological inhibition of P-glycoprotein transport enhances the distribution of HIV-1 protease inhibitors into brain and testes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Brain; Caco-2 Cells; Dibenzocycloheptenes; HIV Protease Inhibitors; Humans; Inhibitory Concentration 50; Male; Mice; Quinolines; Testis | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carnitine; Carrier Proteins; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Humans; Male; Membrane Proteins; Mice; Mice, Inbred C3H; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5; Tetraethylammonium; Tissue Distribution; Tritium | 2001 |
A functional assay for quantitation of the apparent affinities of ligands of P-glycoprotein in Caco-2 cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Biological Transport, Active; Caco-2 Cells; Drug Interactions; Humans; Ligands; Models, Theoretical; Paclitaxel; Tritium | 2001 |
Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Knockout; Morphine; Narcotics; Perfusion; Quinidine; Sex Characteristics; Substrate Specificity; Verapamil | 2001 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection | 2001 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
Topics: Amino Acid Sequence; Animals; Base Sequence; Cloning, Molecular; COS Cells; DNA; Heart Block; Heart Diseases; Humans; Mice; Molecular Sequence Data; Potassium Channels; Potassium Channels, Voltage-Gated; Shaker Superfamily of Potassium Channels; Trinucleotide Repeats | 2002 |
Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Cell Line; Digoxin; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Genes, MDR; Humans; Intestinal Mucosa; Transfection | 2002 |
Are MDCK cells transfected with the human MRP2 gene a good model of the human intestinal mucosa?
Topics: Animals; Caco-2 Cells; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Humans; Intestinal Mucosa; Mitochondrial Proteins; Multidrug Resistance-Associated Protein 2; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Transfection; Vinblastine | 2002 |
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine | 2002 |
Isolation and characterization of Caco-2 subclones expressing high levels of multidrug resistance protein efflux transporter.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Clone Cells; Dogs; Gene Expression Regulation; Humans | 2003 |
Inhibition of P-glycoprotein by newer antidepressants.
Topics: Animals; Antidepressive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Endothelium, Vascular; Humans; Reproducibility of Results; Swine; Transfection | 2003 |
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine | 2003 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2003 |
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2003 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Biological Transport; Cell Line; Dogs; Equilibrative Nucleoside Transport Proteins; Humans; Membrane Transport Proteins; Nerve Tissue Proteins; Organic Cation Transport Proteins; Tyramine | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
A clinical drug library screen identifies astemizole as an antimalarial agent.
Topics: Animals; Antimalarials; Astemizole; Chloroquine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Resistance; Drug Resistance, Multiple; Humans; Mice; Plasmodium falciparum; Plasmodium yoelii | 2006 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding.
Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results | 2011 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
A refined cytochrome P540 IC₅₀ shift assay for reliably identifying CYP3A time-dependent inhibitors.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Enzyme Inhibitors; High-Throughput Screening Assays; Humans; Inhibitory Concentration 50; Microsomes, Liver; Time Factors | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Anti-prion activities and drug-like potential of functionalized quinacrine analogs with basic phenyl residues at the 9-amino position.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport; Blood-Brain Barrier; Cell Line, Tumor; Dogs; Humans; Madin Darby Canine Kidney Cells; Mice; Peptide Fragments; Permeability; Piperazines; Piperidines; Prion Diseases; Prions; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Quinacrine; Recombinant Proteins; Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
MICE models: superior to the HERG model in predicting Torsade de Pointes.
Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors.
Topics: Aryl Hydrocarbon Hydroxylases; Cell Line, Tumor; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Resistance, Viral; HIV Integrase Inhibitors; HIV-1; Humans; Isoquinolines; Molecular Docking Simulation; Mutation; Structure-Activity Relationship | 2014 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Humans; Indans; Indoles; Male; Memory; Mice; Models, Molecular; Neuroprotective Agents; Phthalimides; Piperidines; Protein Aggregates; Scopolamine; Structure-Activity Relationship | 2015 |
Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism.
Topics: Animals; Cells, Cultured; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Guinea Pigs; Heart Atria; Humans; Male; Microsomes, Liver; Myocytes, Cardiac; Oxadiazoles; Oxidation-Reduction; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Vasodilator Agents | 2016 |
2-hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs) as human immunodeficiency virus type 1 integrase inhibitors: Influence of the alkylcarboxamide substitution of position 4.
Topics: Alkylation; Anti-HIV Agents; Cell Line; Drug Resistance, Viral; HIV Integrase Inhibitors; Humans; Isoquinolines; Structure-Activity Relationship | 2016 |
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Drug Design; Humans; Kinetics; Ligands; Male; Models, Molecular; Molecular Targeted Therapy; Protein Conformation; Rats; Rats, Wistar; Receptors, Serotonin | 2016 |
MF-8, a novel promising arylpiperazine-hydantoin based 5-HT
Topics: Dose-Response Relationship, Drug; Humans; Hydantoins; Molecular Structure; Piperazines; Receptors, Serotonin; Serotonin Antagonists; Structure-Activity Relationship | 2018 |
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Cytochromes c; Mice; Morpholines; Mycobacterium tuberculosis; Oxidoreductases; Structure-Activity Relationship; Thiophenes; Vero Cells | 2018 |
Hedgehog pathway inhibitors of the acylthiourea and acylguanidine class show antitumor activity on colon cancer in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Proliferation; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Guanidine; Hedgehog Proteins; Humans; Mice; Mice, Nude; Molecular Structure; Neoplasms, Experimental; NIH 3T3 Cells; Structure-Activity Relationship; Thiourea | 2018 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish | 2020 |
Development of an
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Cell Line; Computer Simulation; Endothelial Cells; Gene Knockout Techniques; Humans; Organic Chemicals; Rats, Transgenic | 2021 |
Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Histone Deacetylases; Histone Demethylases; Humans; Microsomes, Liver; Molecular Docking Simulation; Molecular Structure; Rats; Stomach Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2021 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
[Drug therapy of pre-excitation syndromes].
Topics: Adrenergic beta-Antagonists; Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Humans; Lidocaine; Quinidine; Syndrome; Tachycardia, Paroxysmal; Verapamil | 1977 |
[Drug therapy of tachyarrhythmias (author's transl)].
Topics: Action Potentials; Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Calcium; Disopyramide; Electrophysiology; Humans; Lidocaine; Mexiletine; Myocardial Infarction; Phenytoin; Procainamide; Quinidine; Tachycardia; Verapamil | 1978 |
The treatment of supraventricular arrhythmias.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Cardiac Pacing, Artificial; Digoxin; Disopyramide; Electric Countershock; Humans; Phenytoin; Procainamide; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Verapamil | 1979 |
[Drug therapy of tachycardial heart-rhythm disorders].
Topics: Adrenergic beta-Antagonists; Ajmaline; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Cardiac Complexes, Premature; Humans; Lidocaine; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Verapamil | 1976 |
[Various aspects of individualization of drug therapy of extrasystole].
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Atropine; Belladonna Alkaloids; Cardiac Complexes, Premature; Drug Evaluation; Drug Therapy, Combination; Humans; Injections, Intravenous; Middle Aged; Oxprenolol; Potassium Magnesium Aspartate; Procainamide; Propranolol; Quinidine; Strophanthins; Verapamil | 1977 |
["Torsades de pointe" and reentry induced by anti-arrhythmia agents].
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Flutter; Bretylium Compounds; Cardiac Complexes, Premature; Humans; Phenytoin; Prenylamine; Quinidine; Tachycardia; Ventricular Fibrillation; Verapamil | 1978 |
[Letter: Paroxysmal supraventricular and ventricular tachycardia].
Topics: Adrenergic beta-Antagonists; Aprindine; Heart Ventricles; Humans; Lidocaine; Phenytoin; Quinidine; Tachycardia, Paroxysmal; Time Factors; Verapamil | 1975 |
[New aspects concerning drug therapy of arrhythmia].
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Ajmaline; Arrhythmias, Cardiac; Autonomic Nervous System; Bretylium Compounds; Humans; Lidocaine; Membrane Potentials; Parasympatholytics; Parasympathomimetics; Phenytoin; Procainamide; Quinidine; Verapamil | 1975 |
[Research on a rational basis for the origin and treatment of arrhythmia].
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Heart; Humans; Hyperthyroidism; Potassium; Propranolol; Quinidine; Rabbits; Refractory Period, Electrophysiological; Sodium; Verapamil | 1977 |
Modern concepts of cardiovascular disease.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Electrocardiography; Heart; Heart Conduction System; Humans; Lidocaine; Quinidine; Verapamil | 1979 |
Series on pharmacology in practice. 2. Antiarrhythmic drug therapy.
Topics: Anti-Arrhythmia Agents; Bretylium Compounds; Disopyramide; Humans; Lidocaine; Metoprolol; Procainamide; Propranolol; Quinidine; Verapamil | 1979 |
[Effectiveness of obsidan, isoptin, procaine amide and quinidine in the treatment of various types of arrhythmia].
Topics: Arrhythmias, Cardiac; Drug Evaluation; Humans; Middle Aged; Procainamide; Propranolol; Quinidine; Verapamil | 1977 |
Antiarrhythmic drugs: clinical pharmacology and therapeutic uses.
Topics: Acebutolol; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digitalis Glycosides; Disopyramide; Humans; Kinetics; Lidocaine; Mexiletine; Oxytocin; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil | 1978 |
[Verapamil associated with quinidine in the treatment of chronic atrial fibrillation].
Topics: Adult; Aged; Atrial Fibrillation; Chronic Disease; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Quinidine; Verapamil | 1978 |
Anti-arrhythmic effects of verapamil--a comparative study.
Topics: Animals; Arrhythmias, Cardiac; Dogs; Female; Male; Quinidine; Verapamil | 1978 |
[Drug-induced conversion of arterial fibrillation/flutter by a verapamil/quinidine combination].
Topics: Atrial Fibrillation; Atrial Flutter; Drug Therapy, Combination; Humans; Quinidine; Verapamil | 1978 |
[Oral Verapamil therapy in cardiac arrhythmias].
Topics: Administration, Oral; Arrhythmias, Cardiac; Drug Therapy, Combination; Humans; Quinidine; Verapamil | 1978 |
[The influence of antiarrhythmic drugs on the exercise-ecg (author's transl)].
Topics: Adult; Ajmaline; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Exercise Test; Heart Rate; Humans; Methods; Phenytoin; Propranolol; Quinidine; Verapamil | 1977 |
[Sino-atrial conduction time].
Topics: Ajmaline; Disopyramide; Heart Conduction System; Humans; Phenytoin; Quinidine; Time Factors; Verapamil | 1977 |
Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs.
Topics: Animals; Aprindine; Arrhythmias, Cardiac; Coronary Disease; Disease Models, Animal; Dogs; Heart Conduction System; Indenes; Isoproterenol; Quinidine; Verapamil | 1977 |
[Basic comments on the treatment of arrhythmias].
Topics: Ajmaline; Arrhythmias, Cardiac; Heart Block; Humans; Hypnotics and Sedatives; Lidocaine; Pacemaker, Artificial; Procainamide; Quinidine; Sparteine; Verapamil | 1977 |
[Effect of various anti-arrhythmia agents on phase structure of cardiac cycle and ballistocardiograph].
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Ballistocardiography; Drug Evaluation; Drug Therapy, Combination; Humans; Myocardial Contraction; Procainamide; Propranolol; Quinidine; Verapamil | 1977 |
Effect of quinidine and temperature on sodium uptake and contraction frequency of cultured rat myocardial cells.
Topics: Action Potentials; Animals; Cell Membrane Permeability; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; In Vitro Techniques; Membrane Potentials; Myocardial Contraction; Myocardium; Quinidine; Rats; Sodium; Temperature; Verapamil | 1976 |
Pharmacological compounds affecting plasma glucagon levels in rats.
Topics: Animals; Atropine; Blood Glucose; Depression, Chemical; Fatty Acids, Nonesterified; Glucagon; Insulin; Male; Nicotinic Acids; Physical Exertion; Procaine; Propranolol; Quinidine; Rats; Reserpine; Swimming; Verapamil | 1976 |
Effects of atrio-ventricular conduction of calcium-antagonistic coronary vasodilators, local anaesthetics and quinidine injected into the posterior and the anterior septal artery of the atrio-ventricular node preparation of the dog.
Topics: Action Potentials; Anesthetics, Local; Animals; Atrioventricular Node; Benzazepines; Calcium; Coronary Circulation; Coronary Vessels; Diltiazem; Dogs; Female; Heart Conduction System; In Vitro Techniques; Injections; Lidocaine; Male; Neural Conduction; Nifedipine; Procaine; Quinidine; Vasodilator Agents; Verapamil | 1976 |
Drugs of choice for atrial tachycardia.
Topics: Administration, Oral; Digitalis Glycosides; Digoxin; Edrophonium; Humans; Lanatosides; Metaraminol; Neostigmine; Parasympathomimetics; Propranolol; Quinidine; Tachycardia; Verapamil | 1975 |
[Anti-arrhythmic therapy with verapamil by intravenous infusion].
Topics: Adolescent; Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Electric Countershock; Electrocardiography; Female; Heart Block; Humans; Infusions, Parenteral; Injections, Intravenous; Male; Middle Aged; Quinidine; Tachycardia, Paroxysmal; Ventricular Fibrillation; Verapamil; Wolff-Parkinson-White Syndrome | 1975 |
Effect of drugs in the wolff-parkinson-white syndrome.
Topics: Ajmaline; Digitalis Glycosides; Electric Stimulation; Humans; Lidocaine; Procainamide; Propranolol; Quinidine; Verapamil; Wolff-Parkinson-White Syndrome | 1975 |
Mechanism of action of antidysrhythmic drugs on ventricular conduction as studied with intramural electrodes.
Topics: Ajmaline; Animals; Disopyramide; Dogs; Electrocardiography; Heart Conduction System; Hydroxyzine; Lidocaine; Oxprenolol; Phenytoin; Propranolol; Purkinje Fibers; Quinidine; Verapamil | 1975 |
[Quinidine, procainamide and isoptin].
Topics: Action Potentials; Heart Conduction System; Humans; Procainamide; Quinidine; Verapamil | 1975 |
[Treatment of arrhythmia in general practice].
Topics: Ajmaline; Anti-Arrhythmia Agents; Aprindine; Arrhythmia, Sinus; Arrhythmias, Cardiac; Bradycardia; Humans; Isoproterenol; Lidocaine; Myocardial Infarction; Pacemaker, Artificial; Phenytoin; Procainamide; Propranolol; Quinidine; Tachycardia; Verapamil | 1975 |
Electrophysiologic properties of antidysrhythmic drugs as a rational basis for therapy.
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Hemodynamics; Humans; Lidocaine; Osmolar Concentration; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil | 1976 |
Pharmacology of the myocardium: antiarrhythmic therapy.
Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Lidocaine; Membrane Potentials; Myocardium; Procainamide; Quinidine; Sodium; Verapamil | 1976 |
[Influence of anti-arrhythmia agents on electrolyte metabolism].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Coronary Disease; Female; Gallopamil; Humans; Hypertension; Male; Middle Aged; Potassium; Propranolol; Quinidine; Sodium; Verapamil | 1976 |
[Effects of liensinine on haemodynamics in rats and the physiologic properties of isolated rabbit atria].
Topics: Alkaloids; Animals; Anti-Arrhythmia Agents; Benzylisoquinolines; Female; Hemodynamics; In Vitro Techniques; Isoquinolines; Male; Myocardial Contraction; Phenols; Quinidine; Rabbits; Rats; Rats, Sprague-Dawley; Verapamil | 1992 |
Overexpression of the multidrug resistance gene product in adult rat hepatocytes during primary culture.
Topics: Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Northern; Cell Membrane; Cell Survival; Cells, Cultured; Cyclosporine; Doxorubicin; Drug Resistance; Gene Expression; Liver; Male; Membrane Glycoproteins; Nifedipine; Quinidine; Rats; Rats, Inbred Strains; RNA, Messenger; Verapamil; Vincristine | 1992 |
Reduced mRNA levels for the multidrug-resistance genes in cAMP-dependent protein kinase mutant cell lines.
Topics: Adrenal Glands; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Cyclic AMP; Cytotoxins; Female; Membrane Glycoproteins; Mice; Molecular Sequence Data; Mutation; Ovary; Polymerase Chain Reaction; Precipitin Tests; Protein Kinases; Quinidine; RNA, Messenger; Steroids; Transcription, Genetic; Transfection; Verapamil | 1992 |
Transport of digoxin by human P-glycoprotein expressed in a porcine kidney epithelial cell line (LLC-PK1).
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Digoxin; Drug Interactions; Gene Expression; Humans; Kidney Tubules; Membrane Glycoproteins; Quinidine; Swine; Transfection; Verapamil | 1992 |
The MDR1 gene product, P-glycoprotein, mediates the transport of the cardiac glycoside, digoxin.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Digoxin; Dose-Response Relationship, Drug; Drug Resistance; Kinetics; Membrane Glycoproteins; Quinidine; Verapamil; Vinblastine | 1992 |
Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells.
Topics: Adenosine Triphosphate; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Leukemia L1210; Methotrexate; Mice; Probenecid; Prostaglandins A; Quinidine; Reserpine; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil; Vincristine | 1992 |
[Clinical effectiveness of cordarone in combination with other anti-arrhythmia agents in refractory atrial fibrillation and adverse effects of the drugs].
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Drug Therapy, Combination; Humans; Middle Aged; Moricizine; Quinidine; Verapamil | 1992 |
Correlation between the inhibitory effects of basic drugs on the uptake of cardiac glycosides and taurocholate by isolated rat hepatocytes.
Topics: Animals; Chlorpromazine; Dipyridamole; Disopyramide; Drug Interactions; In Vitro Techniques; Lidocaine; Liver; Male; Nifedipine; Ouabain; Propranolol; Quinidine; Rats; Rats, Wistar; Sodium; Taurocholic Acid; Verapamil | 1992 |
Inhibition by basic drugs of digoxin secretion into human bile.
Topics: Bile; Chromatography, High Pressure Liquid; Digoxin; Drug Interactions; Humans; Probenecid; Quinidine; Quinine; Radioimmunoassay; Spironolactone; Verapamil | 1992 |
[Clinical efficacy of combined therapy with verapamil and fast sodium channel blockers for refractory atrial fibrillation].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Therapy, Combination; Humans; Middle Aged; Moricizine; Phenothiazines; Procainamide; Quinidine; Sodium Channels; Verapamil | 1991 |
Agents which reverse multidrug-resistance are inhibitors of [3H]vinblastine transport by isolated vesicles.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Biological Transport, Active; Carcinoma, Squamous Cell; Cell Membrane; Dihydropyridines; Drug Resistance; Humans; Kinetics; Leucine; Membrane Glycoproteins; Phenothiazines; Quinidine; Trifluoperazine; Tumor Cells, Cultured; Verapamil; Vinblastine | 1991 |
Mechanisms of potassium channel block in rat alveolar epithelial cells.
Topics: Animals; Calcium; Calcium Channels; Capsaicin; Cells, Cultured; Charybdotoxin; Chlorpromazine; Epithelium; Gallopamil; Kinetics; Nifedipine; Phencyclidine; Potassium Channels; Pulmonary Alveoli; Quinidine; Rats; Scorpion Venoms; Tacrine; Tetraethylammonium Compounds; Verapamil | 1990 |
Amiodarone, verapamil, and quinidine do not affect equilibrium binding of digoxin.
Topics: Amiodarone; Animals; Binding, Competitive; Digoxin; Dogs; Myocardium; Quinidine; Receptors, Drug; Sarcolemma; Sodium-Potassium-Exchanging ATPase; Verapamil | 1990 |
Human fetal tracheal smooth muscle produces spontaneous electromechanical oscillations that are Ca2+ dependent and cholinergically potentiated.
Topics: Acetylcholine; Calcium; Electrophysiology; Embryonic and Fetal Development; Female; Humans; In Vitro Techniques; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Pregnancy; Pregnancy Trimester, First; Quinidine; Receptors, Cholinergic; Trachea; Verapamil | 1991 |
Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative.
Topics: Amiodarone; Animals; Cyclosporins; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Flow Cytometry; Leukemia, Experimental; Leukemia, Myeloid; Microscopy, Fluorescence; Quinacrine; Quinidine; Tumor Cells, Cultured; Verapamil | 1991 |
[Combined action of anti-arrhythmia agents].
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Drug Therapy, Combination; Prajmaline; Propranolol; Quinidine; Trimecaine; Verapamil | 1991 |
Effects of bepridil, diltiazem and verapamil on atrial refractoriness and heart rate in the conscious dog: comparison with quinidine.
Topics: Animals; Arrhythmias, Cardiac; Atrial Function, Right; Bepridil; Blood Pressure; Diltiazem; Dogs; Female; Heart; Heart Rate; Male; Pressoreceptors; Quinidine; Tachycardia; Verapamil | 1991 |
The role of beta-blockade therapy for ventricular tachycardia induced with isoproterenol: a prospective analysis.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Cardiac Pacing, Artificial; Drug Evaluation; Female; Heart Ventricles; Humans; Isoproterenol; Male; Middle Aged; Procainamide; Propranolol; Prospective Studies; Quinidine; Tachycardia; Verapamil | 1990 |
[Efficacy of isoproterenol, magnesium sulfate and verapamil for torsade de pointes].
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Electrocardiography; Isoproterenol; Magnesium Sulfate; Quinidine; Torsades de Pointes; Verapamil | 1991 |
Barium-induced nondriven action potentials as a model of triggered potentials from early afterdepolarizations: significance of slow channel activity and differing effects of quinidine and amiodarone.
Topics: Action Potentials; Amiodarone; Animals; Barium; Calcium Channels; Dogs; Female; Heart Conduction System; Isoproterenol; Male; Membrane Potentials; Purkinje Fibers; Quinidine; Tachycardia; Verapamil | 1990 |
[Atrial tachycardia with block in congenital atrial septal defect. A case report].
Topics: Drug Therapy, Combination; Heart Block; Heart Septal Defects, Atrial; Humans; Male; Middle Aged; Quinidine; Tachycardia, Ectopic Atrial; Tachycardia, Supraventricular; Verapamil | 1990 |
Potential usefulness of quinine to circumvent the anthracycline resistance in clinical practice.
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Colonic Neoplasms; Drug Resistance; Drug Synergism; Epirubicin; In Vitro Techniques; Quinidine; Quinine; Rats; Verapamil | 1990 |
[Torsade de pointes induced by quinidine: a case treated successfully with verapamil].
Topics: Adult; Atrial Fibrillation; Electrocardiography; Humans; Quinidine; Torsades de Pointes; Verapamil | 1990 |
Activity of various amphiphilic agents in reversing multidrug resistance of L 1210 cells.
Topics: Animals; Drug Resistance; Ethylamines; Hycanthone; Leukemia L1210; Phenotype; Piperidines; Quinidine; Quinine; Tamoxifen; Trifluoperazine; Verapamil | 1990 |
Role of endocytosis in the action of ether lipids on WEHI-3B, HL60, and FDCP-mix A4 cells.
Topics: Animals; Antineoplastic Agents; Azepines; Cell Survival; Chloroquine; Diltiazem; Drug Synergism; Endocytosis; Furans; Humans; Hydroxyzine; In Vitro Techniques; Leukemia, Myeloid; Mice; Nifedipine; Phospholipid Ethers; Platelet Activating Factor; Pyridines; Quinidine; Quinine; Sodium Fluoride; Thiazoles; Triazoles; Verapamil | 1990 |
Use-dependent action of antiarrhythmic drugs in frog skeletal muscle and canine cardiac Purkinje fiber.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dogs; In Vitro Techniques; Kinetics; Lidocaine; Microelectrodes; Muscle Contraction; Muscles; Purkinje Fibers; Quinidine; Rana esculenta; Tetrodotoxin; Verapamil | 1990 |
Volume regulation in liver: further characterization by inhibitors and ionic substitutions.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Acetazolamide; Amiloride; Animals; Barium; Chlorides; Hydrogen-Ion Concentration; Liver; Male; Osmolar Concentration; Potassium; Quinidine; Raffinose; Rats; Rats, Inbred Strains; Verapamil; Water-Electrolyte Balance | 1990 |
Human multi-drug-resistant cancer cells exhibit a high degree of selectivity for stereoisomers of verapamil and quinidine.
Topics: Cell Line; Cell Survival; Coloring Agents; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; HeLa Cells; Humans; Neoplasms; Quinidine; Stereoisomerism; Tetrazolium Salts; Thiazoles; Verapamil; Vincristine | 1990 |
Potassium channels mediate killing by human natural killer cells.
Topics: 4-Aminopyridine; Aminopyridines; Cadmium; Calcium; Cytotoxicity, Immunologic; Electric Conductivity; Humans; Ion Channels; Killer Cells, Natural; Membrane Potentials; Potassium; Quinidine; Verapamil | 1986 |
Potassium channels in human NK cells are involved in discrete stages of the killing process.
Topics: 4-Aminopyridine; Aminopyridines; Cadmium; Calcium; Cytotoxicity, Immunologic; Edetic Acid; Humans; Ion Channels; Killer Cells, Natural; Killer Factors, Yeast; Proteins; Quinidine; Verapamil | 1986 |
Certain calcium channel blockers bind specifically to multidrug-resistant human KB carcinoma membrane vesicles and inhibit drug binding to P-glycoprotein.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carcinoma; Cell Line; Diltiazem; Drug Resistance; Glycoproteins; Humans; Nitrendipine; Quinidine; Verapamil; Vinblastine | 1987 |
Effect of ion channel blockers on immune response and course of experimental allergic neuritis.
Topics: Animals; Antibody Formation; Cell Division; Electrophysiology; Ion Channels; Lymphocytes; Neuritis, Autoimmune, Experimental; Quinidine; Rats; Rats, Inbred Lew; Sciatic Nerve; Verapamil | 1989 |
Circulatory and myocardial effects of different sodium antagonistic drugs in comparison to the calcium antagonist verapamil.
Topics: Animals; Cardiac Output; Disopyramide; Flecainide; Heart; Hemodynamics; In Vitro Techniques; Injections, Intravenous; Male; Quinidine; Rats; Rats, Inbred Strains; Sodium; Verapamil | 1989 |
Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line; Drug Resistance; Female; Genes; Humans; Methotrexate; Ovarian Neoplasms; Phenotype; Quinazolines; Quinidine; RNA, Messenger; Trimetrexate; Tumor Cells, Cultured; Verapamil | 1989 |
Inhibition of vincristine binding to plasma membrane vesicles from daunorubicin-resistant Ehrlich ascites cells by multidrug resistance modulators.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Cycle; Cell Membrane; Daunorubicin; Drug Resistance; Polysorbates; Quinidine; Trifluoperazine; Tumor Stem Cell Assay; Verapamil; Vincristine | 1989 |
[Pharmacologic restoration of sinus rhythm in atrial flutter and fibrillation].
Topics: Atrial Fibrillation; Atrial Flutter; Digoxin; Drug Therapy, Combination; Female; Heart Rate; Humans; Male; Middle Aged; Quinidine; Verapamil | 1989 |
[Combination of quinidine and verapamil in auricular fibrillation].
Topics: Administration, Oral; Adult; Aged; Atrial Fibrillation; Drug Evaluation; Drug Therapy, Combination; Humans; Middle Aged; Quinidine; Verapamil | 1989 |
[Interactions between quinidine and verapamil].
Topics: Adult; Drug Interactions; Half-Life; Heart Diseases; Humans; Male; Middle Aged; Quinidine; Verapamil | 1989 |
Additive competitive interaction of verapamil and quinidine at alpha-adrenergic receptors of isolated cardiac guinea pig myocytes and human platelets.
Topics: Animals; Binding, Competitive; Blood Platelets; Cell Membrane; Cells, Cultured; Drug Interactions; Guinea Pigs; Humans; Isomerism; Kinetics; Myocardium; Nitrendipine; Quinidine; Receptors, Adrenergic, alpha; Verapamil | 1988 |
Properties of verapamil-hypersensitive multidrug-resistant Chinese hamster ovary cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cricetinae; Drug Resistance; Membrane Glycoproteins; Membrane Proteins; Quinidine; Verapamil; Vincristine | 1988 |
[Pharmacological cardioversion of paroxysmal atrial fibrillation: 3 methods compared].
Topics: Aged; Amiodarone; Atrial Fibrillation; Deslanoside; Drug Evaluation; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Methods; Middle Aged; Quinidine; Verapamil | 1987 |
Hypotension after quinidine plus verapamil. Possible additive competition at alpha-adrenergic receptors.
Topics: Aged; Animals; Arrhythmias, Cardiac; Binding, Competitive; Drug Synergism; Drug Therapy, Combination; Female; Humans; Hypotension; In Vitro Techniques; Male; Middle Aged; Quinidine; Radioligand Assay; Rats; Receptors, Adrenergic, alpha; Verapamil | 1985 |
Ca2+-activated K+ conductance causes membrane hyperpolarizations in a monkey kidney cell line (JTC-12).
Topics: Animals; Calcium; Cell Line; Cell Membrane; Haplorhini; Kidney; Membrane Potentials; Microelectrodes; Potassium; Quinidine; Tetraethylammonium Compounds; Verapamil | 1988 |
Stability of milrinone and digoxin, furosemide, procainamide hydrochloride, propranolol hydrochloride, quinidine gluconate, or verapamil hydrochloride in 5% dextrose injection.
Topics: Digoxin; Drug Combinations; Drug Stability; Drug Storage; Furosemide; Glucose; Indicators and Reagents; Milrinone; Procainamide; Propranolol; Pyridones; Quinidine; Solutions; Temperature; Verapamil | 1988 |
ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.
Topics: Adenosine Triphosphate; Antineoplastic Agents; Biological Transport, Active; Cell Membrane; Drug Resistance; Humans; Hydrolysis; KB Cells; Kinetics; Quinidine; Verapamil; Vinblastine | 1988 |
[Treatment of recently developed atrial fibrillation using a combination of Kinilentin and Isoptin].
Topics: Adult; Atrial Fibrillation; Drug Therapy, Combination; Female; Heart Valves; Humans; Male; Postoperative Complications; Quinidine; Verapamil | 1988 |
Ion shifts in myocardial cells during ischemia and reperfusion and the effect of membrane stabilizing agents on ischemic ion transport.
Topics: Animals; Biological Transport, Active; Calcium; Cations; Cell Membrane Permeability; Coronary Disease; Guinea Pigs; In Vitro Techniques; Intracellular Fluid; Lidocaine; Myocardium; Potassium; Quinidine; Sodium; Verapamil | 1987 |
Differential effect of some antiarrhythmic drugs in right- or left-sided aconitine-induced experimental atrial arrhythmias.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dogs; Female; Male; Propranolol; Quinidine; Sotalol; Verapamil | 1987 |
Potassium conductance in straight proximal tubule cells of the mouse. Effect of barium, verapamil and quinidine.
Topics: Animals; Barium; Cell Membrane; Female; In Vitro Techniques; Kidney Tubules, Proximal; Kinetics; Membrane Potentials; Mice; Potassium; Quinidine; Verapamil | 1987 |
Effects of quinidine, verapamil and nifedipine on the pharmacokinetics and pharmacodynamics of digitoxin during steady state conditions.
Topics: Digitoxin; Drug Interactions; Electrocardiography; Heart; Humans; Kinetics; Nifedipine; Prospective Studies; Quinidine; Verapamil | 1987 |
Effects of antiarrhythmic agents on isoproterenol-induced ventricular fibrillation in heavy rats: a possible model of sudden cardiac death.
Topics: Animals; Anti-Arrhythmia Agents; Body Weight; Bretylium Tosylate; Death, Sudden; Disease Models, Animal; Electrocardiography; Isoproterenol; Male; Niacin; Phenytoin; Procainamide; Propranolol; Quaternary Ammonium Compounds; Quinidine; Rats; Ventricular Fibrillation; Verapamil | 1986 |
Interaction between adenosine and antiarrhythmic agents in atrial myocardium of guinea-pig.
Topics: Action Potentials; Adenosine; Animals; Anti-Arrhythmia Agents; Drug Interactions; Electric Stimulation; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardial Contraction; Quinidine; Verapamil | 1986 |
Clinical digoxin toxicity in the aged in association with co-administered verapamil. A report of two cases and review of the literature.
Topics: Aged; Digoxin; Drug Interactions; Female; Heart Diseases; Humans; Kinetics; Quinidine; Verapamil | 1986 |
Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: effects of verapamil and other drugs.
Topics: Biological Transport; Carcinoma; Cell Nucleus; Daunorubicin; Drug Resistance; Humans; KB Cells; Quinidine; Verapamil; Vinblastine; Vincristine | 1986 |
Medicolegal problems in the management of cardiac arrhythmias in children.
Topics: Arrhythmias, Cardiac; Child; Child, Preschool; Humans; Infant, Newborn; Long QT Syndrome; Malpractice; Quinidine; Sick Sinus Syndrome; Tachycardia, Supraventricular; Verapamil | 1987 |
Digoxin interactions. The influence of quinidine and verapamil on the pharmacokinetics and receptor binding of digitalis glycosides.
Topics: Animals; Digitalis Glycosides; Digoxin; Drug Interactions; Humans; Kinetics; Quinidine; Receptors, Drug; Sodium-Potassium-Exchanging ATPase; Verapamil | 1985 |
Calcium channel blockers that prolong the QT interval.
Topics: Animals; Arrhythmias, Cardiac; Bepridil; Calcium Channel Blockers; Dogs; Electrocardiography; Heart Atria; Heart Ventricles; Humans; Lidoflazine; Pyrrolidines; Quinidine; Systole; Verapamil | 1985 |
Treatment of fetal cardiac arrhythmias.
Topics: Amiodarone; Arrhythmia, Sinus; Arrhythmias, Cardiac; Chromosome Aberrations; Chromosome Disorders; Diagnosis, Differential; Digoxin; Drug Therapy, Combination; Echocardiography; Edema, Cardiac; Female; Fetal Diseases; Fetal Growth Retardation; Fetal Heart; Gestational Age; Heart Rate; Humans; Karyotyping; Lung; Maternal-Fetal Exchange; Pregnancy; Procainamide; Prognosis; Propranolol; Quinidine; Ultrasonography; Vena Cava, Superior; Verapamil | 1985 |
The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of paroxysmal tachycardias.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Cardiomyopathies; Chromatography, High Pressure Liquid; Disopyramide; Electric Stimulation; Electrocardiography; Female; Humans; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Infarction; Propafenone; Propiophenones; Quinidine; Tachycardia, Paroxysmal; Time Factors; Tocainide; Verapamil | 1985 |
Increased quinidine plasma concentrations during administration of verapamil: a new quinidine-verapamil interaction.
Topics: Adult; Drug Interactions; Half-Life; Heart Block; Humans; Kinetics; Male; Quinidine; Tachycardia; Transposition of Great Vessels; Verapamil | 1986 |
Refractory supraventricular tachycardia in the neonate: treatment with temporary antitachycardial pacing.
Topics: Cardiac Pacing, Artificial; Combined Modality Therapy; Digoxin; Drug Therapy, Combination; Electric Countershock; Electrocardiography; Humans; Infant, Newborn; Male; Quinidine; Recurrence; Tachycardia, Paroxysmal; Verapamil | 1985 |
Interaction between digoxin and commonly coadministered drugs in children.
Topics: Amiodarone; Child, Preschool; Digoxin; Drug Interactions; Drug Therapy, Combination; Humans; Infant; Infant, Newborn; Nifedipine; Quinidine; Spironolactone; Verapamil | 1985 |
Effects of lidocaine, procaine, procainamide and quinidine on electrophysiological properties of cultured embryonic chick hearts.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Chick Embryo; Electric Stimulation; Heart; Heart Ventricles; Histamine; Isoproterenol; Lidocaine; Membrane Potentials; Organ Culture Techniques; Procainamide; Procaine; Propranolol; Quinidine; Verapamil | 1985 |
[Interaction with digoxin].
Topics: Digoxin; Drug Interactions; Humans; Quinidine; Verapamil | 1985 |
[Progress in the therapy of cardiac arrhythmias with special consideration of verapamil].
Topics: Adams-Stokes Syndrome; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bradycardia; Cardiac Complexes, Premature; Electrocardiography; Heart-Lung Machine; Humans; Nitriles; Quinidine; Tachycardia; Tachycardia, Paroxysmal; Vasodilator Agents; Verapamil | 1970 |
[Arrhythmia in a patient with pre-exitation WPW-syndrome].
Topics: Adult; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Electrocardiography; Heart Conduction System; Humans; Male; Quinidine; Tachycardia; Verapamil; Wolff-Parkinson-White Syndrome | 1970 |
[What is assured in the treatment of heart arrhythmia?].
Topics: Adrenergic beta-Antagonists; Ajmaline; Atrial Fibrillation; Atrial Flutter; Atropine; Bradycardia; Cardiac Complexes, Premature; Heart Block; Humans; Lidocaine; Metaproterenol; Phenytoin; Procainamide; Quinidine; Tachycardia; Verapamil | 1972 |
A fresh look at cardiac arrhythmias. Therapy.
Topics: Action Potentials; Adrenergic beta-Antagonists; Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Digitalis Glycosides; Heart; Heart Conduction System; Humans; Pacemaker, Artificial; Procainamide; Quinidine; Verapamil; Wolff-Parkinson-White Syndrome | 1974 |
[Modern therapy of cardiac arrhythmias].
Topics: Adrenergic beta-Antagonists; Ajmaline; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atropine; Bradycardia; Humans; Lidocaine; Metaproterenol; Phenytoin; Procainamide; Quinidine; Tachycardia; Verapamil | 1973 |
[The treatment of cardiac arrhythmias: complexity and schematization].
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Benzofurans; Digitalis Glycosides; Electric Countershock; Lidocaine; Phenytoin; Potassium; Procainamide; Quinidine; Tachycardia; Verapamil | 1973 |
Inotropic stimuli and systolic transmembrane calcium flow in depolarized guinea-pig atria.
Topics: Action Potentials; Animals; Calcium; Cell Membrane; Edetic Acid; Electric Stimulation; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Isoproterenol; Membrane Potentials; Ouabain; Potassium; Quinidine; Stimulation, Chemical; Temperature; Time Factors; Verapamil | 1974 |
[Influence of beta-adrenolytic substances on the action of digitalis glycosides].
Topics: Animals; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Propranolol; Quinidine; Reserpine; Strophanthins; Tachycardia; Verapamil | 1967 |
[On the influence of beta-receptor blocking agents, iproveratril, quinidine and reserpine on the effect of k-strophanthin in the guinea pig heart].
Topics: Animals; Anti-Arrhythmia Agents; Atrial Function; Electric Stimulation; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Muscle Contraction; Nitriles; Propranolol; Quinidine; Reserpine; Strophanthins; Sympatholytics; Vasodilator Agents; Verapamil | 1967 |
[Influence of active antiarrhythmia substances on refractory period and contractility of guinea pig atria].
Topics: Animals; Anti-Arrhythmia Agents; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Lidocaine; Muscle Contraction; Nitriles; Phenytoin; Plants, Medicinal; Procainamide; Quinidine; Rauwolfia; Reaction Time; Sparteine; Vasodilator Agents; Verapamil | 1969 |
Actions of antiarrhythmic drugs on refractory period and contractility of isolated rat and guinea-pig atria.
Topics: Ajmaline; Animals; Anti-Arrhythmia Agents; Ethers; Ethylamines; Glycerol; Guinea Pigs; Heart Atria; Lidocaine; Male; Muscle Contraction; Phenytoin; Procainamide; Propranolol; Quinidine; Rats; Sparteine; Verapamil | 1971 |
The effect of quinidine and drugs with quinidine-like action (propranolol, verapamil and tetracaine) on the calcium transport system in isolated sarcoplasmic reticulum vesicles of rabbit skeletal muscle.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Biological Transport; Calcium; Membranes; Muscles; Phospholipases; Propranolol; Quinidine; Rabbits; Sarcoplasmic Reticulum; Tetracaine; Verapamil | 1972 |
A comparison of the antiarrhythmic actions of two new synthetic compounds, iproveratril and MJ 1999, with quinidine and pronethalol.
Topics: Aconitum; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Dogs; Electrocardiography; Epinephrine; Ethanolamines; Female; Heart Rate; Male; Ouabain; Quinidine; Tachycardia; Verapamil | 1967 |
[Quinidine-like action components of beta-receptor antagonists and related substances. Experiments on isolated guinea pig papillary muscles].
Topics: Action Potentials; Adrenergic beta-Antagonists; Animals; Calcium; Depression, Chemical; Guinea Pigs; Heart; In Vitro Techniques; Isoproterenol; Papillary Muscles; Procainamide; Quinidine; Sodium; Sympatholytics; Verapamil | 1969 |
The influence of pharmacological blockade of presynaptic and postsynaptic adrenergic structures on electrically induced arrhythmias of the guinea-pig atria.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Depression, Chemical; Guanethidine; Guanidines; Guinea Pigs; Heart; Heart Atria; In Vitro Techniques; Papaverine; Plants, Medicinal; Procaine; Propranolol; Quinidine; Rauwolfia; Receptors, Drug; Sympatholytics; Verapamil | 1969 |
[Clinical pharmacology and adverse effects of various anti-arrhythmic drugs].
Topics: Adrenergic beta-Antagonists; Aged; Anti-Arrhythmia Agents; Bone Marrow Diseases; Central Nervous System Diseases; Female; Gastrointestinal Diseases; Heart Diseases; Hemodynamics; Humans; Imidazoles; Isoproterenol; Lidocaine; Membrane Potentials; Phenytoin; Plants, Medicinal; Procainamide; Quinidine; Rauwolfia; Verapamil | 1971 |
[Action of antiarrhythmic and -receptor blocking drugs on functional refractory period and contractility of electrically stimulated guinea-pig atria].
Topics: Adrenergic beta-Antagonists; Alprenolol; Animals; Anti-Arrhythmia Agents; Atrial Function; Drug Interactions; Electric Stimulation; Guinea Pigs; Male; Muscle Contraction; Phenytoin; Procainamide; Propranolol; Quinidine; Reserpine; Sparteine; Sympatholytics; Time Factors; Verapamil | 1971 |
[Repetitive paroxysmal tachycardia in childhood (author's transl)].
Topics: Adolescent; Child, Preschool; Chronic Disease; Digitalis Glycosides; Electrocardiography; Female; Heart Rate; Humans; Infant; Infant, Newborn; Male; Quinidine; Recurrence; Tachycardia, Paroxysmal; Time Factors; Verapamil | 1974 |
[Action of anti-arrhythmia agents on intracardiac conduction].
Topics: Ajmaline; Aniline Compounds; Animals; Anti-Arrhythmia Agents; Benzofurans; Bundle of His; Cardiac Catheterization; Depression, Chemical; Diethylamines; Dogs; Electrocardiography; Heart Conduction System; Indans; Iodobenzoates; Lidocaine; Lidoflazine; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil | 1974 |
[Combined treatment of auricular fibrillation and other tachycardiac arrhythmias using quinidine and verapamil].
Topics: Adult; Aged; Atrial Fibrillation; Drug Combinations; Female; Humans; Male; Middle Aged; Quinidine; Tachycardia; Verapamil | 1972 |
Experimental evaluation of antiarrhythmic drugs in the guinea pig.
Topics: Aconitum; Ajmaline; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Guinea Pigs; Lidocaine; Phenytoin; Procainamide; Propranolol; Quinidine; Strophanthins; Verapamil | 1973 |
[Effect of quinidine, iproveratril, lidocaine and sparteine on ECG and circulatory system of the anesthetized cat].
Topics: Anesthesia; Animals; Blood Pressure; Cats; Drug Interactions; Electrocardiography; Heart; Heart Rate; Hemodynamics; Injections, Intraperitoneal; Lidocaine; Male; Pentobarbital; Quinidine; Sinoatrial Node; Sparteine; Verapamil | 1973 |
[Trials of auricular defibrillation with the quinidine-verapamil combination by oral route].
Topics: Administration, Oral; Adult; Aged; Atrial Fibrillation; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Quinidine; Verapamil | 1972 |
[Study of combinations of verapamil and quinidine].
Topics: Aconitum; Animals; Arrhythmias, Cardiac; Dogs; Drug Synergism; Electrocardiography; Guinea Pigs; Heart; Ouabain; Pacemaker, Artificial; Quinidine; Verapamil | 1971 |
Antiarrhythmic actions of coronary vasodilator agents papaverine, dioxyline and verapamil.
Topics: Aconitum; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Dogs; Epinephrine; Female; Heart Atria; Heart Ventricles; Hydrocarbons; Isoquinolines; Male; Nitriles; Ouabain; Papaverine; Quinidine; Tachycardia; Vasodilator Agents; Verapamil | 1970 |
[Disturbances of cardiac rhythm and their treatment].
Topics: Adult; Aged; Ajmaline; Arrhythmias, Cardiac; Digitoxin; Digoxin; Humans; Lidocaine; Metaproterenol; Middle Aged; Phenytoin; Procainamide; Quinidine; Reserpine; Verapamil | 1970 |
[Late results of treating auricular flutter and fibrillation using controlled cardiac phasic electroshock].
Topics: Atrial Fibrillation; Atrial Flutter; Cardiac Glycosides; Electric Countershock; Humans; Premedication; Quinidine; Verapamil | 1971 |
[Comparative studies in the heart-lung-preparation of dog on the action spectrum of verapamil, quinidine and some alpha- and beta-sympatholytics as well as the effect of adrenaline].
Topics: Animals; Anti-Arrhythmia Agents; Depression, Chemical; Dibenzylchlorethamine; Dogs; Drug Synergism; Electric Conductivity; Epinephrine; Heart; Heart Conduction System; Heart Rate; Nitriles; Phentolamine; Propranolol; Quinidine; Sensory Receptor Cells; Sympatholytics; Vasodilator Agents; Verapamil | 1968 |
[Differential therapy of tachycardial arrhythmias].
Topics: Anti-Arrhythmia Agents; Humans; Lidocaine; Metaproterenol; Phenytoin; Procainamide; Quinidine; Reserpine; Sparteine; Sympatholytics; Tachycardia; Tachycardia, Paroxysmal; Verapamil | 1969 |
Drugs and the heart. IV. Antiarrhythmic agents.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Heart Conduction System; Hemodynamics; Humans; Lidocaine; Mexiletine; Procainamide; Quinidine; Verapamil | 1980 |
[Long-term use of amiodarone in the treatment of ventricular pre-excitation with tachyarrhythmia attacks].
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Benzofurans; Drug Therapy, Combination; Humans; Quinidine; Tachycardia; Verapamil; Wolff-Parkinson-White Syndrome | 1981 |
[Treatment of supraventricular tachycardia].
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Digitalis Glycosides; Electrocardiography; Humans; Quinidine; Tachycardia; Verapamil | 1981 |
[Effects of anti-arrhythmia agents on heart rate. Significance and importance].
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Disopyramide; Electrocardiography; Heart Conduction System; Heart Rate; Humans; Lidocaine; Propafenone; Propiophenones; Quinidine; Verapamil | 1981 |
Inhibition of adrenaline-induced platelet aggregation by the alpha-adrenoceptor blocking drug benextramine.
Topics: Adenosine Diphosphate; Adrenergic alpha-Antagonists; Collagen; Cystamine; Epinephrine; Humans; Phentolamine; Platelet Aggregation; Quinidine; Verapamil | 1982 |
Antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil | 1983 |
[Pharmacotherapy of paroxysmal tachycardia].
Topics: Adrenergic beta-Antagonists; Atrial Fibrillation; Atrial Flutter; Digitalis Glycosides; Disopyramide; Heart Failure; Humans; Quinidine; Tachycardia, Paroxysmal; Verapamil | 1983 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil | 1984 |
[Ventricular tachycardia in bursts. Electrophysiological and therapeutical study].
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Child; Electrocardiography; Humans; Middle Aged; Periodicity; Quinidine; Tachycardia; Verapamil | 1980 |
[Combination treatment of atrial arrhythmias with quinidine-verapamil].
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Complexes, Premature; Drug Therapy, Combination; Female; Heart Atria; Humans; Male; Middle Aged; Quinidine; Tachycardia; Verapamil | 1980 |
[Enhancement of the antifibrillatory efficacy of quinidine in atrial fibrillation by verapamil (author's transl)].
Topics: Animals; Atrial Fibrillation; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Diltiazem; Dogs; Drug Therapy, Combination; Electrocardiography; Female; Male; Quinidine; Verapamil | 1982 |
[Cordichin in the treatment of ventricular extrasystole and tachycardial rhythm disorders].
Topics: Aged; Blood Pressure; Cardiac Complexes, Premature; Drug Combinations; Electrocardiography; Female; Heart Rate; Humans; Male; Middle Aged; Quinidine; Tachycardia; Verapamil | 1982 |
[Chinidin and verapamil combined against atrial arrhythmias].
Topics: Atrial Fibrillation; Atrial Flutter; Cardiac Complexes, Premature; Drug Therapy, Combination; Heart Rate; Humans; Quinidine; Verapamil | 1982 |
[Cellular effects of anti-arrhythmia drugs. Their predictive value of therapeutic effects].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Catecholamines; Electrolytes; Heart Conduction System; Humans; Ion Channels; Lidocaine; Prognosis; Quinidine; Verapamil | 1981 |
The effect of bepridil, verapamil, and quinidine in the prevention of ventricular tachycardia induced by programmed electrical stimulation in the digitalized dog.
Topics: Animals; Anti-Arrhythmia Agents; Bepridil; Dogs; Electric Stimulation; Electrocardiography; Electrophysiology; Female; Male; Pyrrolidines; Quinidine; Tachycardia; Verapamil | 1984 |
Characteristics of the digoxin-quinidine and digoxin-verapamil interactions in the rat kidney.
Topics: Animals; Binding, Competitive; Digoxin; Drug Interactions; Iodine Radioisotopes; Kidney; Kinetics; Male; Protein Binding; Quinidine; Rats; Rats, Inbred Strains; Verapamil | 1984 |
Antiarrhythmic actions of verapamil against ischaemic arrhythmias in the rat.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Blood Pressure; Coronary Disease; Electric Stimulation; Electrocardiography; Kinetics; Myocardial Contraction; Quinidine; Rats; Verapamil | 1984 |
[Quinidine interactions with propranolol, phenytoin, verapamil and procainamide].
Topics: Arrhythmias, Cardiac; Drug Interactions; Drug Therapy, Combination; Female; Half-Life; Humans; Male; Middle Aged; Phenytoin; Procainamide; Propranolol; Quinidine; Verapamil | 1984 |
Electrophysiological effects of quinidine alone and of the combination quinidine-verapamil on AV conduction in humans.
Topics: Adult; Arrhythmias, Cardiac; Atrial Fibrillation; Bundle of His; Bundle-Branch Block; Drug Therapy, Combination; Electrocardiography; Heart Conduction System; Humans; Quinidine; Ventricular Fibrillation; Verapamil | 1983 |
Interaction of digoxin with verapamil, indomethacin, and other coadministered drugs: a comparative study in rat tissue.
Topics: Animals; Creatinine; Digoxin; Indomethacin; Male; Quinidine; Rats; Rats, Inbred Strains; Verapamil | 1983 |
Effects of diltiazem on vulnerability to atrial and ventricular reentrant arrhythmias in the normal and ischemic heart.
Topics: Animals; Arrhythmias, Cardiac; Benzazepines; Coronary Disease; Diltiazem; Dogs; Electrophysiology; Female; Male; Myocardial Infarction; Quinidine; Verapamil | 1983 |
Verapamil and quinidine effects on PAH transport by isolated perfused renal tubules.
Topics: Aminohippuric Acids; Animals; Biological Transport; Epithelium; Female; Kidney Tubules; Male; Mathematics; p-Aminohippuric Acid; Perfusion; Permeability; Quinidine; Verapamil | 1984 |
[Method of evaluating antiarrhythmic therapy in patients with paroxysms of supraventricular tachycardia].
Topics: Adolescent; Adult; Ajmaline; Amiodarone; Anti-Arrhythmia Agents; Digoxin; Drug Evaluation; Electric Stimulation; Female; Humans; Male; Middle Aged; Procainamide; Propranolol; Quinidine; Tachycardia, Paroxysmal; Verapamil | 1984 |
[Combined administration of quinidine and verapamil in chronic atrial fibrillation and atrial flutter (author's transl].
Topics: Adult; Aged; Atrial Fibrillation; Atrial Flutter; Drug Combinations; Female; Humans; Male; Middle Aged; Quinidine; Verapamil | 1982 |
[Treatment of paroxysmal forms of auricular fibrillation and atrial flutter in a cardiological hospital].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Cardiac Glycosides; Drug Therapy, Combination; Female; Hospitalization; Hospitals, Special; Humans; Male; Middle Aged; Potassium Chloride; Procainamide; Quinidine; Strophanthins; Verapamil | 1983 |
[Clinical pharmacology of anti-arrhythmia agents].
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Humans; Lidocaine; Quinidine; Verapamil | 1983 |
[Efficacy of Cordichin in recurrent supraventicular tachycardia].
Topics: Administration, Oral; Adult; Aged; Drug Combinations; Electrocardiography; Female; Humans; Male; Middle Aged; Quinidine; Tablets; Tachycardia, Paroxysmal; Verapamil | 1983 |
Anti-arrhythmic agents in ischemic heart disease: supraventricular arrhythmias, digitalis toxicity and chronic stable ventricular ectopic beats.
Topics: Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Digitalis; Digoxin; Heart Ventricles; Humans; Plants, Medicinal; Plants, Toxic; Potassium; Quinidine; Verapamil | 1982 |
Verapamil: its potential for causing serious complications in patients with hypertrophic cardiomyopathy.
Topics: Arrhythmias, Cardiac; Blood Pressure; Cardiomyopathy, Hypertrophic; Death, Sudden; Depression, Chemical; Drug Interactions; Heart Arrest; Humans; Hypotension; Myocardial Contraction; Pulmonary Edema; Quinidine; Verapamil | 1981 |
Myocardial conduction time and antiarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disopyramide; Dogs; Electrophysiology; Heart Conduction System; Lidocaine; Quinidine; Ventricular Function; Verapamil | 1981 |
[Quinidine and verapamil combination therapy for the treatment of atrial arrhythmias].
Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Drug Combinations; Heart Atria; Humans; Quinidine; Verapamil | 1981 |
Antiarrhythmic drugs.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Drug Therapy, Combination; Humans; Lidocaine; Quinidine; Verapamil | 1981 |
[Conversion of recent atrial fibrillation to sinus rhythm. Predictive value of the clinical and echocardiographic parameters].
Topics: Adult; Aged; Amiodarone; Atrial Fibrillation; Benzofurans; Digitalis Glycosides; Echocardiography; Electric Countershock; Female; Follow-Up Studies; Humans; Male; Middle Aged; Quinidine; Verapamil | 1981 |
Complete abolition of the reentrant supraventricular tachycardia zone using a new modality of cardiac pacing with simultaneous atrioventricular stimulation.
Topics: Adult; Atrioventricular Node; Cardiac Pacing, Artificial; Digoxin; Electrodes; Electrophysiology; Female; Follow-Up Studies; Heart Conduction System; Heart Ventricles; Humans; Male; Middle Aged; Propranolol; Quinidine; Tachycardia; Time Factors; Verapamil | 1980 |
[Concealed Mobitz type II exit block simulating intermittent parasystole and a concealed trigeminy variant with parasystolic rhythm. Observations in the interaction with quinidine].
Topics: Aged; Arrhythmia, Sinus; Electrocardiography; Heart Block; Humans; Male; Quinidine; Sinoatrial Block; Verapamil | 1980 |
[A case of arrhythmogenic effects of quinidine, digoxin and finoptin combination].
Topics: Adult; Arrhythmias, Cardiac; Digoxin; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Quinidine; Verapamil | 1995 |
Electrocardiological profile and proarrhythmic effects of quinidine, verapamil and their combination: a mapping study.
Topics: Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug Combinations; Electrophysiology; Heart; Male; Quinidine; Rabbits; Verapamil | 1995 |
Blockade of cardiac outwardly rectifying K+ channels by TEA and class III antiarrhythmics--evidence against a single drug-sensitive channel site.
Topics: Animals; Animals, Newborn; Anti-Arrhythmia Agents; Cells, Cultured; Cytosol; Heart; Ion Channel Gating; Ion Channels; Myocardium; Potassium Channels; Quinidine; Rats; Tetraethylammonium Compounds; Verapamil | 1994 |
Chronotropic cardiac effects of falipamil in conscious dogs: interactions with the autonomic nervous system and various ionic conductances.
Topics: Animals; Atropine; Autonomic Nervous System; Blood Pressure; Cardiovascular Agents; Dogs; Female; Heart Rate; Ion Channels; Isoindoles; Male; Phthalimides; Pindolol; Quinidine; Receptors, Adrenergic, beta; Receptors, Muscarinic; Stimulation, Chemical; Verapamil | 1994 |
[The effect of calcium current blockers on potential-dependent potassium currents of cultured frog developing skeletal muscle cells].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Cells, Cultured; Membrane Potentials; Muscle, Skeletal; Nifedipine; Potassium; Quinidine; Rana temporaria; Verapamil | 1994 |
[Pseudo AV dissociation caused by interpolated junctional extrasystoles in the presence of a first-degree AV block].
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrioventricular Node; Cardiac Complexes, Premature; Drug Therapy, Combination; Electrocardiography; Female; Heart Block; Humans; Quinidine; Time Factors; Verapamil | 1995 |
Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans.
Topics: Adenosine; Arginine; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Forearm; Humans; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; omega-N-Methylarginine; Plethysmography; Potassium Channels; Quinidine; Regional Blood Flow; Tolbutamide; Vasodilation; Vasodilator Agents; Verapamil | 1995 |
Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Cloning, Molecular; Disopyramide; Dose-Response Relationship, Drug; Mathematics; Oocytes; Potassium Channels; Quaternary Ammonium Compounds; Quinidine; Verapamil; Xenopus laevis | 1995 |
Molecular cloning and functional characterization of a GABA/betaine transporter from human kidney.
Topics: Amino Acid Sequence; Animals; Base Sequence; Betaine; Carrier Proteins; Chlorides; Chromosome Mapping; Chromosomes, Human, Pair 12; Cloning, Molecular; Dogs; GABA Plasma Membrane Transport Proteins; gamma-Aminobutyric Acid; Humans; Kidney Medulla; Kinetics; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Organic Anion Transporters; Phloretin; Quinidine; Sequence Homology, Amino Acid; Sodium; Verapamil | 1995 |
The ACh-induced whole-cell currents in sheep parotid secretory cells. Do BK channels really carry the ACh-evoked whole-cell K+ current?
Topics: 4-Aminopyridine; Acetylcholine; Animals; Barium; Cell Membrane; Chlorides; Parotid Gland; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Quinidine; Quinine; Sensitivity and Specificity; Sheep; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1995 |
Hyperpolarization induced by sodium removal in rabbit sinoatrial node cells. Possible role of electrogenic sodium-calcium exchange.
Topics: Animals; Calcium; In Vitro Techniques; Lidocaine; Membrane Potentials; Ouabain; Quinacrine; Quinidine; Rabbits; Sinoatrial Node; Sodium; Sodium-Potassium-Exchanging ATPase; Verapamil | 1995 |
Effects of K+ channel blockers on inwardly and outwardly rectifying whole-cell K+ currents in sheep parotid secretory cells.
Topics: Animals; Barium; Cesium; Charybdotoxin; In Vitro Techniques; Lidocaine; Membrane Potentials; Parotid Gland; Potassium; Potassium Channels; Quinidine; Quinine; Scorpion Venoms; Sheep; Tetraethylammonium; Tetraethylammonium Compounds; Verapamil | 1993 |
Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Carrier Proteins; Cell Death; Cell Survival; Colchicine; Cyclosporine; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Membrane Glycoproteins; Mice; Phenotype; Point Mutation; Quinidine; Transfection; Verapamil | 1995 |
MDR1 gene expression: its effect on drug resistance to doxorubicin in human hepatocellular carcinoma cell lines.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Carrier Proteins; Cefoperazone; Ceftriaxone; Doxorubicin; Drug Resistance; Drug Synergism; Gene Expression; Humans; Immunohistochemistry; Liver Neoplasms; Membrane Glycoproteins; Neoplasm Proteins; Quinidine; RNA, Messenger; Trifluoperazine; Tumor Cells, Cultured; Verapamil | 1994 |
Mechanism of current-induced early afterdepolarizations in guinea pig ventricular myocytes.
Topics: Action Potentials; Adenosine Diphosphate; Animals; Calcium; Cells, Cultured; Electric Stimulation; Guinea Pigs; Heart; Heart Ventricles; Kinetics; Nisoldipine; Potassium; Quinidine; Ryanodine; Sarcoplasmic Reticulum; Time Factors; Verapamil | 1994 |
Role of P-glycoprotein in renal tubular secretion of digoxin in the isolated perfused rat kidney.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Digoxin; In Vitro Techniques; Inulin; Kidney; Kidney Tubules; Male; Membrane Glycoproteins; Perfusion; Quinidine; Rats; Rats, Wistar; Tritium; Verapamil | 1993 |
ATP-dependent uptake of anti-neoplastic agents by acidic organelles.
Topics: Adenosine Triphosphate; Ammonium Chloride; Animals; Antineoplastic Agents; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cattle; Cells, Cultured; Chromaffin Granules; Daunorubicin; Drug Resistance; Hydrogen-Ion Concentration; Mice; Nigericin; Organelles; Proteolipids; Proton-Translocating ATPases; Quinidine; Reserpine; Valinomycin; Vanadates; Verapamil | 1994 |
Differential effectiveness of a range of novel drug-resistance modulators, relative to verapamil, in influencing vinblastine or teniposide cytotoxicity in human lymphoblastoid CCRF-CEM sublines expressing classic or atypical multidrug resistance.
Topics: Cyclosporine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Flunarizine; Humans; Leukemia, T-Cell; Piperidines; Quinidine; Teniposide; Triazines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |
Identification of a multidrug resistance modulator with clinical potential by analysis of synergistic activity in vitro, toxicity in vivo and growth delay in a solid human tumour xenograft.
Topics: Animals; Calcium Channel Blockers; Doxorubicin; Drug Resistance; Drug Synergism; Epirubicin; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Ovarian Neoplasms; Propylamines; Quinidine; Tumor Cells, Cultured; Verapamil | 1994 |
Pharmacological analysis of voltage-dependent potassium currents in cultured skeletal myocytes of the frog Rana temporaria.
Topics: 4-Aminopyridine; Animals; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Dose-Response Relationship, Drug; Electric Conductivity; Embryo, Nonmammalian; Membrane Potentials; Muscle, Skeletal; Nifedipine; Patch-Clamp Techniques; Potassium Channels; Quinidine; Rana temporaria; Time Factors; Verapamil | 1995 |
Differential effect of selected antiarrhythmic drugs on coronary artery ligation-induced ventricular arrhythmias on the right or left sides.
Topics: Animals; Anti-Arrhythmia Agents; Coronary Disease; Disease Models, Animal; Dogs; Female; Ligation; Male; Propranolol; Quinidine; Sotalol; Tachycardia, Ventricular; Verapamil | 1995 |
Reversal of P-glycoprotein is greatly reduced by the presence of plasma but can be monitored by an ex vivo clinical assay.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Drug Screening Assays, Antitumor; Humans; Kidney; Leukemia P388; Mice; Plasma; Quinidine; Verapamil; Vinblastine | 1996 |
[Conversion rate and prevention of recurrence of paroxysmal and sustained atrial fibrillation or atrial flutter with verapamil/quinidine].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Middle Aged; Quinidine; Retrospective Studies; Tachycardia, Paroxysmal; Treatment Outcome; Verapamil | 1996 |
[Torsade de pointes tachycardia during administration of quinidine and verapamil in atrial fibrillation].
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Combinations; Electrocardiography; Fatal Outcome; Female; Heart Arrest; Humans; Long QT Syndrome; Quinidine; Torsades de Pointes; Verapamil | 1997 |
Pharmacological characterization of LY335979: a potent cyclopropyldibenzosuberane modulator of P-glycoprotein.
Topics: Acridines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dibenzocycloheptenes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Isoquinolines; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Quinidine; Quinolines; Structure-Activity Relationship; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil | 1997 |
The stereoisomers quinine and quinidine exhibit a marked stereoselectivity in the inhibition of hepatobiliary transport of cardiac glycosides.
Topics: Animals; Biliary Tract; Biological Transport; Calcium Channel Blockers; Cardiac Glycosides; Cardiotonic Agents; Digoxin; Drug Interactions; Liver; Male; Metabolic Clearance Rate; Ouabain; Quinidine; Quinine; Rats; Rats, Wistar; Stereoisomerism; Verapamil | 1998 |
Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Digoxin; In Vitro Techniques; Male; Ouabain; Quinidine; Quinine; Rats; Rats, Wistar; Stereoisomerism; Verapamil | 1998 |
Effects of quinidine and verapamil on human cardiovascular alpha1-adrenoceptors.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Cardiovascular System; CHO Cells; Cloning, Molecular; Cricetinae; Humans; Quinidine; Radioligand Assay; Verapamil | 1998 |
Tonic block of the sodium and calcium currents by ketamine in isolated guinea pig ventricular myocytes.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Cells, Cultured; Guinea Pigs; Heart; Heart Ventricles; Ketamine; Membrane Potentials; Quinidine; Sodium Channel Blockers; Sodium Channels; Verapamil | 1998 |
In vitro and in vivo evaluations of intestinal barriers for the zwitterion L-767,679 and its carboxyl ester prodrug L-775,318. Roles of efflux and metabolism.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta-Alanine; Caco-2 Cells; Humans; Intestinal Mucosa; Male; Piperazines; Platelet Glycoprotein GPIIb-IIIa Complex; Prodrugs; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil | 1998 |
Agonist-specific modulation of glucocorticoid receptor-mediated transcription by immunosuppressants.
Topics: Animals; Corticosterone; Cortodoxone; Cyclosporine; Desoxycorticosterone; Dexamethasone; Genes, Reporter; Glucocorticoids; Hydrocortisone; Immunosuppressive Agents; L Cells; Luciferases; Mice; Polyenes; Quinidine; Receptors, Glucocorticoid; Recombinant Fusion Proteins; Sirolimus; Tacrolimus; Transcription, Genetic; Transfection; Triamcinolone Acetonide; Verapamil | 1998 |
Effects of quinidine, verapamil, nifedipine and ouabain on hysteresis in atrial refractoriness in the conscious dog: an approach to ionic mechanisms.
Topics: Animals; Dogs; Female; Heart; Ion Channels; Male; Nifedipine; Ouabain; Quinidine; Refractory Period, Electrophysiological; Sodium-Potassium-Exchanging ATPase; Verapamil | 1999 |
Potassium conductances in isolated single cells from Xenopus laevis colonic epithelium.
Topics: Animals; Barium; Cesium; Colon; Epithelial Cells; Female; Hydrogen-Ion Concentration; Ion Transport; Lidocaine; Membrane Potentials; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Quinidine; Quinine; Tetraethylammonium; Verapamil; Xenopus laevis | 1999 |
The roles of P-glycoprotein and intracellular metabolism in the intestinal absorption of methadone: in vitro studies using the rat everted intestinal sac.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Intestinal Absorption; Intestine, Small; Male; Methadone; Narcotics; Permeability; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil | 1999 |
Metabolism of artelinic acid to dihydroqinqhaosu by human liver cytochrome P4503A.
Topics: Adult; Aged; Antifungal Agents; Antimalarials; Artemisinins; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Combinations; Drug Interactions; Drugs, Chinese Herbal; Enzyme Inhibitors; Female; Glycyrrhiza; Humans; Inactivation, Metabolic; Inhibitory Concentration 50; Isoenzymes; Ketoconazole; Liver; Male; Miconazole; Microsomes, Liver; Middle Aged; Oxidoreductases, N-Demethylating; Paeonia; Quinidine; Recombinant Proteins; Sesquiterpenes; Sulfaphenazole; Troleandomycin; Vasodilator Agents; Verapamil | 1999 |
Effects of ambasilide, quinidine, flecainide and verapamil on ultra-rapid delayed rectifier potassium currents in canine atrial myocytes.
Topics: Aminobenzoates; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds, Heterocyclic; Calcium Channels, L-Type; Dogs; Dose-Response Relationship, Drug; Flecainide; Heart Atria; Myocardium; Patch-Clamp Techniques; Potassium Channels; Quinidine; Time Factors; Verapamil | 2000 |
Studies on the prevention of nigericin action in neuroblastoma X glioma hybrid (NG108-15) cells.
Topics: Calcium Channel Blockers; Electrophysiology; Enzyme Inhibitors; Ionophores; Membrane Potentials; Neuroblastoma; Nigericin; Ouabain; Quinidine; Tumor Cells, Cultured; Verapamil | 2000 |
[Treatment of cardiac arrhythmia in pregnant women].
Topics: Adrenergic beta-Antagonists; Alcohol Drinking; Arrhythmias, Cardiac; Digoxin; Electric Countershock; Female; Heart Valve Diseases; Humans; Lidocaine; Mitral Valve Prolapse; Pregnancy; Pregnancy Complications, Cardiovascular; Procainamide; Quinidine; Secondary Prevention; Smoking; Smoking Prevention; Verapamil | 2000 |
Improved intestinal absorption of sulpiride in rats with synchronized oral delivery systems.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Intestinal Absorption; Lactose; Methylcellulose; Oxazines; Quinidine; Rats; Sulpiride; Verapamil | 2001 |
Cardiovascular effects of verapamil and quinidine at normal and elevated ambient pressure.
Topics: Air Pressure; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Atmospheric Pressure; Heart; Hemodynamics; Male; Potassium Channels; Quinidine; Rats; Rats, Wistar; Verapamil | 2001 |
A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Separation; Cyclosporine; Enzyme Inhibitors; Fluorescent Dyes; Humans; Immunosuppressive Agents; Lymphocytes; Quinidine; Rhodamine 123; Tacrolimus; Verapamil | 2001 |
Effect of P-glycoprotein on flavopiridol sensitivity.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; CHO Cells; Cisplatin; Colchicine; Colony-Forming Units Assay; Cricetinae; Drug Resistance, Multiple; Flavonoids; Paclitaxel; Piperidines; Quinidine; Verapamil | 2001 |
Synchronized neural activity in the Drosophila memory centers and its modulation by amnesiac.
Topics: Aequorin; Age Factors; Animals; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Signaling; Cell Membrane; Cobalt; Diltiazem; Drosophila; Drosophila Proteins; Enzyme Inhibitors; GABA Agonists; Genes, Reporter; Ionophores; Membrane Potentials; Memory; Muscimol; Mutation; Nervous System; Neurons; Neuropeptides; Nicotinic Agonists; Quinidine; Tetrodotoxin; Thapsigargin; Verapamil; Veratridine | 2001 |
Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum.
Topics: Acridine Orange; Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Drug Interactions; Drug Resistance; Fluorescence; Membrane Proteins; Membrane Transport Proteins; Molecular Conformation; Mutation; Parasitic Sensitivity Tests; Plasmodium falciparum; Protozoan Proteins; Quinidine; Quinine; Verapamil | 2002 |
[Atrial fibrillation successfully converted. A new standard in the prevention of recurrence?].
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Calcium Channel Blockers; Chronic Disease; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Humans; Placebos; Quinidine; Randomized Controlled Trials as Topic; Recurrence; Sotalol; Time Factors; Verapamil | 2001 |
Ionic basis of the resting membrane potential and action potential in the pharyngeal muscle of Caenorhabditis elegans.
Topics: 4-Aminopyridine; Action Potentials; Animals; Barium; Caenorhabditis elegans; Calcium; Calcium Channel Blockers; Calcium Channels; Chloride Channels; Chlorides; Electrophysiology; Membrane Potentials; Muscarinic Antagonists; Nifedipine; Pharyngeal Muscles; Potassium; Potassium Channel Blockers; Potassium Channels; Quinidine; Sodium; Sodium Channels; Verapamil; Veratridine | 2002 |
The anthelminthic agent albendazole does not interact with p-glycoprotein.
Topics: Albendazole; Animals; Anthelmintics; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Cell Line; Chromatography, High Pressure Liquid; Digoxin; Enzyme Inhibitors; Humans; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Quinidine; Swine; Tissue Distribution; Verapamil | 2002 |
Basolateral potassium channels of rabbit colon epithelium: role in sodium absorption and chloride secretion.
Topics: Adenosine-5'-(N-ethylcarboxamide); Amphotericin B; Animals; Cell Membrane; Chlorides; Colon; Dose-Response Relationship, Drug; Electric Conductivity; Epithelium; In Vitro Techniques; Intestinal Absorption; Patch-Clamp Techniques; Potassium; Potassium Channel Blockers; Potassium Channels; Quinidine; Rabbits; Sodium; Verapamil | 2002 |
Modulation of P-glycoprotein transport activity in the mouse blood-brain barrier by rifampin.
Topics: Animals; Antibiotics, Antitubercular; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Dose-Response Relationship, Drug; Drug Interactions; Mice; Perfusion; Quinidine; Rifampin; Verapamil | 2003 |
Drug interactions.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 Enzyme System; Digoxin; Drug Interactions; Drug Therapy, Combination; Enzyme Induction; Humans; Isoenzymes; Piperazines; Purines; Quinidine; Sildenafil Citrate; Sulfones; Vasodilator Agents; Ventricular Premature Complexes; Verapamil | 2003 |
Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes.
Topics: Animals; Antidepressive Agents; Antimalarials; Antitussive Agents; Calcium Channel Blockers; Cell Survival; Chlorzoxazone; Coloring Agents; Coumarins; Cryopreservation; Cytochrome P-450 Enzyme System; Dextromethorphan; Imipramine; In Vitro Techniques; Liver; Male; Microsomes, Liver; Muscle Relaxants, Central; Oxazines; Pharmaceutical Preparations; Pharmacokinetics; Quinidine; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Testosterone; Verapamil; Xanthenes | 2003 |
Lack of interaction of digoxin and P-glycoprotein inhibitors, quinidine and verapamil in human placenta in vitro.
Topics: Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Digoxin; Drug Interactions; Enzyme Inhibitors; Female; Humans; Maternal-Fetal Exchange; Organ Culture Techniques; Placenta; Pregnancy; Quinidine; Verapamil | 2003 |
IPROVERATRIL: EXPERIMENTAL DATA ON CORONARY DILATATION AND ANTIARRHYTHMIC ACTION.
Topics: Animals; Anti-Arrhythmia Agents; Anura; Blood Pressure; Bradycardia; Cats; Chloroform; Coronary Vessels; Dilatation; Electrocardiography; Epinephrine; Heart; Heart Rate; Hypotension; Ouabain; Pharmacology; Quinidine; Rabbits; Research; Strophanthins; Toxicology; Vasodilator Agents; Ventricular Fibrillation; Verapamil | 1964 |
Variable modulation of opioid brain uptake by P-glycoprotein in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Benzomorphans; Biological Transport; Brain; Drug Interactions; Fentanyl; Loperamide; Meperidine; Methadone; Mice; Narcotics; Quinidine; Time Factors; Verapamil | 2004 |
Effect of P-glycoprotein on the ocular disposition of a model substrate, quinidine.
Topics: Adrenergic alpha-Antagonists; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Retinal Barrier; Blotting, Western; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Half-Life; Male; Microdialysis; Models, Biological; Quinidine; Rabbits; Retina; Verapamil; Vitreous Body | 2003 |
ABC transporter inhibitors that are substrates enhance lentiviral vector transduction into primitive hematopoietic progenitor cells.
Topics: Adult; Animals; Antigens, CD34; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Centrifugation; Diltiazem; Genetic Therapy; Genetic Vectors; HeLa Cells; Hematopoietic Stem Cells; Humans; Lentivirus; Mice; Mice, Inbred NOD; Mice, SCID; Quinidine; Transduction, Genetic; Verapamil | 2004 |
Organic cation transport by Malpighian tubules of Drosophila melanogaster: application of two novel electrophysiological methods.
Topics: Animals; Biological Transport, Active; Cimetidine; Drosophila melanogaster; Electrophysiology; Ion Transport; Malpighian Tubules; Microelectrodes; Potassium; Quinidine; Tetraethylammonium; Tetraphenylborate; Verapamil; Vinblastine | 2004 |
In situ transport of vinblastine and selected P-glycoprotein substrates: implications for drug-drug interactions at the mouse blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Colchicine; Cyclosporins; Dexamethasone; Drug Interactions; Male; Mice; Mice, Inbred Strains; Morphine; Progesterone; Quinidine; Verapamil; Vinblastine | 2004 |
Assessment of drug interactions in hepatobiliary transport using rhodamine 123 in sandwich-cultured rat hepatocytes.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Culture Techniques; Cells, Cultured; Collagenases; Digoxin; Drug Interactions; Hepatocytes; Male; Progesterone; Quercetin; Quinidine; Rats; Rats, Wistar; Rhodamine 123; Verapamil | 2005 |
In vivo evidence for the efflux transport of pentazocine from the brain across the blood-brain barrier using the brain efflux index method.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Carnitine; Dose-Response Relationship, Drug; Drug Carriers; Drug Evaluation, Preclinical; Half-Life; Inulin; Male; Microinjections; Pentazocine; Quinidine; Rats; Rats, Wistar; Tetraethylammonium; Tritium; Verapamil | 2005 |
Quinidine plus verapamil vs. quinidine alone to prevent recurrences of atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Therapy, Combination; Humans; Quinidine; Secondary Prevention; Verapamil | 2005 |
[PAFAC Study. Secondary prevention of atrial fibrillation after cardioversion].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Drug Therapy, Combination; Electric Countershock; Female; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Quinidine; Secondary Prevention; Sotalol; Survival Analysis; Treatment Outcome; Verapamil | 2005 |
The effects of sinomenine on intestinal absorption of paeoniflorin by the everted rat gut sac model.
Topics: Animals; Anti-Inflammatory Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzoates; Bridged-Ring Compounds; Digoxin; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Glucosides; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Models, Animal; Monoterpenes; Morphinans; Paeonia; Quinidine; Rats; Rats, Sprague-Dawley; Sinomenium; Time Factors; Verapamil | 2006 |
pH-dependent functional activity of P-glycoprotein in limiting intestinal absorption of protic drugs: kinetic analysis of quinidine efflux in situ.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Chromatography, High Pressure Liquid; Furosemide; Hydrochlorothiazide; Hydrogen-Ion Concentration; Ileum; Intestinal Absorption; Jejunum; Membranes, Artificial; Perfusion; Permeability; Propranolol; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil | 2005 |
Development of an on-line extraction turbulent flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples.
Topics: Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Dexamethasone; Etoposide; Furosemide; Humans; Metoprolol; Nadolol; Pharmaceutical Preparations; Propranolol; Quinidine; Rhodamine 123; Spectrometry, Mass, Electrospray Ionization; Sulfasalazine; Verapamil | 2006 |
Influence of erythromycin on the pharmacokinetics of ximelagatran may involve inhibition of P-glycoprotein-mediated excretion.
Topics: Adult; Animals; Anti-Bacterial Agents; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azetidines; Benzylamines; Bile; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Cell Line; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Female; Humans; In Vitro Techniques; Male; Partial Thromboplastin Time; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil | 2006 |
Pharmacological rescue of carnitine transport in primary carnitine deficiency.
Topics: Adult; Animals; Biological Transport; Carnitine; Child, Preschool; CHO Cells; Cricetinae; Cricetulus; Curcumin; DNA Mutational Analysis; DNA, Complementary; Endoplasmic Reticulum; Enzyme Inhibitors; Female; Humans; Infant; Male; Mutation, Missense; Organic Cation Transport Proteins; Phenylbutyrates; Quinidine; Solute Carrier Family 22 Member 5; Verapamil; Vitamin B Deficiency | 2006 |
Use of a failing rabbit heart as a model to predict torsadogenicity.
Topics: Amiodarone; Animals; Cardiac Output, Low; Cisapride; Dose-Response Relationship, Drug; Electrocardiography; Models, Animal; Phenethylamines; Quaternary Ammonium Compounds; Quinidine; Rabbits; Sulfonamides; Torsades de Pointes; Verapamil | 2006 |
The complexity of intestinal absorption and exsorption of digoxin in rats.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acridines; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Digoxin; Ileum; In Vitro Techniques; Intestinal Absorption; Jejunum; Male; Microvilli; Organic Anion Transporters; Propionates; Quinidine; Quinolines; Rats; Rats, Sprague-Dawley; Sulfobromophthalein; Tetrahydroisoquinolines; Verapamil | 2006 |
Comparison of permeation enhancing strategies for an oral factor Xa inhibitor using the Caco-2 cell monolayer model.
Topics: Algorithms; Antithrombin III; Caco-2 Cells; Cell Membrane Permeability; Chitosan; Drug Synergism; Glycerides; Humans; Molecular Structure; Probenecid; Prodrugs; Quinidine; Serine Proteinase Inhibitors; Spectrophotometry, Ultraviolet; Verapamil | 2006 |
Induction of human P-glycoprotein in Caco-2 cells: development of a highly sensitive assay system for P-glycoprotein-mediated drug transport.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Caco-2 Cells; Cell Differentiation; Cell Growth Processes; Cell Line; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Digoxin; Gene Expression; Humans; Membrane Transport Proteins; Microfilament Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Peptide Transporter 1; Pharmaceutical Preparations; Quinidine; RNA, Messenger; Symporters; Verapamil; Vinblastine | 2006 |
Species differences of inhibitory effects on P-glycoprotein-mediated drug transport.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cyclosporine; Daunorubicin; Digoxin; Dogs; Dose-Response Relationship, Drug; Humans; Mice; Quinidine; Rats; Species Specificity; Verapamil | 2007 |
Development and validation of RP-HPLC-UV method for simultaneous determination of buparvaquone, atenolol, propranolol, quinidine and verapamil: a tool for the standardization of rat in situ intestinal permeability studies.
Topics: Animals; Antiprotozoal Agents; Atenolol; Buffers; Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Intestinal Mucosa; Male; Molecular Structure; Naphthoquinones; Perfusion; Permeability; Propranolol; Quinidine; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Verapamil | 2007 |
In situ kinetic modelling of intestinal efflux in rats: functional characterization of segmental differences and correlation with in vitro results.
Topics: Algorithms; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Ciprofloxacin; Colon; Cyclosporine; Dose-Response Relationship, Drug; Fluoroquinolones; Immunosuppressive Agents; Intestinal Absorption; Intestinal Mucosa; Intestine, Small; Kinetics; Male; Models, Biological; Molecular Structure; Muscarinic Antagonists; p-Aminohippuric Acid; Permeability; Quinidine; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 2007 |
Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge.
Topics: Abietanes; Adenosine Triphosphate; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Digoxin; Dogs; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Microsomes, Liver; Multidrug Resistance-Associated Proteins; Phenanthrenes; Plant Roots; Probenecid; Propionates; Quinidine; Quinolines; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Temperature; Transfection; Verapamil | 2007 |
Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Cells, Cultured; Endothelial Cells; Isoflavones; Male; Mice; Mice, Knockout; Permeability; Phenols; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil | 2007 |
Role of P-glycoprotein in restricting the brain penetration of tanshinone IIA, a major active constituent from the root of Salvia miltiorrhiza Bunge, across the blood-brain barrier.
Topics: Abietanes; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cells, Cultured; Endothelial Cells; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Knockout; Multidrug Resistance-Associated Proteins; Phenanthrenes; Plant Roots; Quinidine; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Salvia miltiorrhiza; Verapamil | 2007 |
Protein concentration and pH affect the apparent P-glycoprotein-ATPase activation kinetics.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Humans; Hydrogen-Ion Concentration; Kinetics; Monensin; Quinidine; Verapamil | 2008 |
In vitro-to-in vivo prediction of P-glycoprotein-based drug interactions at the human and rodent blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Boron Compounds; Carbamates; Carbon Radioisotopes; Cyclosporine; Drug Interactions; Fluorescent Dyes; Furans; Humans; LLC-PK1 Cells; Positron-Emission Tomography; Quinidine; Quinine; Rats; Sulfonamides; Swine; Verapamil | 2008 |
Effect of calcium-channel antagonist on repolarization heterogeneity of ventricular myocardium in an in vitro rabbit model of long QT syndrome.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Female; Heart Ventricles; In Vitro Techniques; Long QT Syndrome; Male; Myocardium; Quinidine; Rabbits; Tachycardia, Ventricular; Verapamil | 2007 |
Scaling of in vitro membrane permeability to predict P-glycoprotein-mediated drug absorption in vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Membrane Permeability; Humans; Ileum; Intestinal Absorption; Jejunum; Male; Quinidine; Rats; Rats, Wistar; Verapamil; Vinblastine | 2008 |
Electrical storm in a patient with arrhythmogenic right ventricular cardiomyopathy and SCN5A mutation.
Topics: Anti-Arrhythmia Agents; Arrhythmogenic Right Ventricular Dysplasia; Electrocardiography; Humans; Male; Middle Aged; Muscle Proteins; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Quinidine; Sodium Channels; Verapamil | 2008 |
Possible participation of chloride ion channels in ATP release from cancer cells in suspension.
Topics: Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Adhesion; Cell Line, Tumor; Chloride Channels; Fibrosarcoma; Gadolinium; Gap Junctions; Glycyrrhetinic Acid; Humans; Niflumic Acid; Nitrobenzoates; Peptides; Quinidine; Verapamil | 2009 |
Grapefruit juice and its constituents augment colchicine intestinal absorption: potential hazardous interaction and the role of p-glycoprotein.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Caco-2 Cells; Cell Polarity; Citrus paradisi; Colchicine; Dose-Response Relationship, Drug; Flavanones; Food-Drug Interactions; Fruit; Furocoumarins; Humans; Ileum; Intestinal Absorption; Jejunum; Male; Permeability; Quinidine; Rats; Rats, Wistar; Risk Assessment; Time Factors; Tubulin Modulators; Verapamil | 2009 |
Vitreal kinetics of quinidine in rabbits in the presence of topically coadministered P-glycoprotein substrates/modulators.
Topics: Administration, Topical; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Drug Interactions; Erythromycin; Fluorescein; Fluorescent Dyes; Half-Life; Male; Metabolic Clearance Rate; Ophthalmic Solutions; Prednisolone; Quinidine; Rabbits; Tissue Distribution; Verapamil; Vitreous Body | 2009 |
Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: a quantitative analysis of regional drug exposure in the brain.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Capillaries; Colchicine; Dose-Response Relationship, Drug; Infusions, Subcutaneous; Inulin; Least-Squares Analysis; Linear Models; Loperamide; Mice; Mice, Inbred Strains; Mice, Knockout; Microdissection; Perfusion; Quinidine; Regional Blood Flow; Substrate Specificity; Verapamil | 2009 |
Xenopus laevis oocytes expressing human P-glycoprotein: probing trans- and cis-inhibitory effects on [3H]vinblastine and [3H]digoxin efflux.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Digoxin; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Female; High-Throughput Screening Assays; Humans; Kinetics; Microinjections; Oocytes; Quinidine; Temperature; Verapamil; Vinblastine; Xenopus laevis | 2010 |
Model analysis of the concentration-dependent permeability of P-gp substrates.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Gene Expression; Humans; Models, Biological; Quinidine; Verapamil; Vinblastine | 2010 |
Human and murine embryonic stem cell-derived cardiomyocytes serve together as a valuable model for drug safety screening.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Embryonic Stem Cells; Humans; Mice; Myocytes, Cardiac; Quinidine; Sotalol; Verapamil | 2010 |
Interaction between topically and systemically coadministered P-glycoprotein substrates/inhibitors: effect on vitreal kinetics.
Topics: Administration, Topical; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Erythromycin; Injections, Intravenous; Male; Mass Spectrometry; Microdialysis; Ophthalmic Solutions; Prednisolone; Quinidine; Rabbits; Substrate Specificity; Time Factors; Tissue Distribution; Verapamil; Vitreous Body | 2010 |
Comparison of drug permeabilities across the blood-retinal barrier, blood-aqueous humor barrier, and blood-brain barrier.
Topics: Animals; Blood-Aqueous Barrier; Blood-Brain Barrier; Blood-Retinal Barrier; Digoxin; Male; Permeability; Pharmacokinetics; Quinidine; Rats; Rats, Sprague-Dawley; Tritium; Verapamil | 2011 |
Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation.
Topics: Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Interactions; Erythromycin; Gene Expression; Glycerol; Humans; Intestinal Absorption; Loperamide; Models, Biological; Pharmaceutical Preparations; Propanolamines; Puromycin; Quinidine; Saquinavir; Solubility; Surface-Active Agents; Terfenadine; Verapamil; Vinblastine | 2011 |
Use of uptake intrinsic clearance from attached rat hepatocytes to predict hepatic clearance for poorly permeable compounds.
Topics: Animals; Bosentan; Capillary Permeability; Chromatography, Liquid; Cyclosporine; Dogs; Fluorobenzenes; Hepatocytes; Madin Darby Canine Kidney Cells; Male; Metabolic Clearance Rate; Pyrimidines; Quinidine; Rats; Rats, Sprague-Dawley; Rifampin; Rosuvastatin Calcium; Sulfonamides; Tandem Mass Spectrometry; Verapamil; Xenobiotics | 2012 |
Vasospastic angina with J-wave pattern and polymorphic ventricular tachycardia effectively treated with quinidine.
Topics: Angina Pectoris, Variant; Atrial Fibrillation; Atrial Flutter; Catheter Ablation; Combined Modality Therapy; Defibrillators, Implantable; Drug Therapy, Combination; Electrocardiography; Electrocardiography, Ambulatory; Exercise Test; Follow-Up Studies; Humans; Isosorbide; Male; Middle Aged; Molsidomine; Quinidine; Risk Assessment; Severity of Illness Index; Tachycardia, Ventricular; Treatment Outcome; Verapamil | 2012 |
The liver partition coefficient-corrected inhibitory quotient and the pharmacokinetic-pharmacodynamic relationship of directly acting anti-hepatitis C virus agents in humans.
Topics: Animals; Antiviral Agents; Cells, Cultured; Digoxin; Doxorubicin; Hepacivirus; Hepatocytes; Humans; Imipramine; Liver; Male; Mice; Quinidine; Rats; Rats, Sprague-Dawley; Verapamil | 2012 |
Ontogenic development of cardiomyocytes derived from transgene-free human induced pluripotent stem cells and its homology with human heart.
Topics: Animals; Biomarkers; Cell Differentiation; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Isoproterenol; Mice; Mice, SCID; Microelectrodes; Myocytes, Cardiac; Quinidine; Real-Time Polymerase Chain Reaction; Sodium; Verapamil | 2013 |
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease Models, Animal; Edema; Gentamicins; Heart Diseases; Heart Rate; Heart Ventricles; Larva; Microinjections; Nimodipine; Pericardium; Quinidine; Terfenadine; Tetracycline; Toxicity Tests; Verapamil; Yolk Sac; Zebrafish | 2014 |
Menadione serves as a substrate for P-glycoprotein: implication in chemosensitizing activity.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Dogs; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Fluorescent Dyes; Humans; Madin Darby Canine Kidney Cells; MCF-7 Cells; Quinidine; Rhodamine 123; Transfection; Verapamil; Vitamin K 3 | 2013 |
Silencing of P-glycoprotein increases mortality in temephos-treated Aedes aegypti larvae.
Topics: Aedes; Amino Acid Sequence; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Gene Expression; Insecticide Resistance; Larva; Molecular Sequence Data; Mortality; Quinidine; Temefos; Verapamil | 2013 |
Physiologically based pharmacokinetic modelling and in vivo [I]/K(i) accurately predict P-glycoprotein-mediated drug-drug interactions with dabigatran etexilate.
Topics: Amiodarone; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; beta-Alanine; Clarithromycin; Dabigatran; Digoxin; Dronedarone; Drug Interactions; Humans; Models, Biological; Pyridines; Quinidine; Verapamil | 2014 |
Impact of P-glycoprotein on blood-retinal barrier permeability: comparison of blood-aqueous humor and blood-brain barrier using mdr1a knockout rats.
Topics: Animals; Aqueous Humor; ATP Binding Cassette Transporter, Subfamily B; Biological Transport, Active; Blood-Aqueous Barrier; Blood-Brain Barrier; Blood-Retinal Barrier; Brain; Calcium Channel Blockers; Capillary Permeability; Digoxin; Gene Knockout Techniques; Male; Quinidine; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Retina; Verapamil; Voltage-Gated Sodium Channel Blockers | 2014 |
Looking for virtuous promiscuity: electrocardiographic evidence of multichannel drug block.
Topics: Acetanilides; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Phenethylamines; Piperazines; Potassium Channel Blockers; Quinidine; Ranolazine; Sulfonamides; Verapamil | 2014 |
Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites.
Topics: Animals; Antimalarials; Binding Sites; Binding, Competitive; Biological Transport; Cells, Cultured; Chloroquine; Drug Resistance; Female; Hydrogen-Ion Concentration; Kinetics; Membrane Transport Proteins; Plasmodium falciparum; Protozoan Proteins; Quinidine; Quinine; Verapamil; Xenopus laevis | 2014 |
Possible involvement of cationic-drug sensitive transport systems in the blood-to-brain influx and brain-to-blood efflux of amantadine across the blood-brain barrier.
Topics: 1-Methyl-4-phenylpyridinium; Amantadine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Cell Line; Cyclosporine; Ion Pumps; Male; Microinjections; Quinidine; Rats; Rhodamine 123; Tritium; Verapamil | 2015 |
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Cyclosporins; In Vitro Techniques; Intestinal Mucosa; Isoquinolines; Ketoconazole; Male; Quinazolines; Quinidine; Rats, Wistar; Rhodamine 123; Verapamil | 2015 |
Novel in vitro transport method for screening the reversibility of P-glycoprotein inhibitors.
Topics: ATP Binding Cassette Transporter, Subfamily B; Biological Transport; Caco-2 Cells; Cell Culture Techniques; Cell Survival; Cyclosporine; Drug Evaluation, Preclinical; Humans; Quinidine; Verapamil | 2016 |
The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Cytochrome P-450 CYP3A; Drug Interactions; Ileum; Intestinal Absorption; Jejunum; Ketoconazole; Male; Pharmaceutical Preparations; Quinidine; Rats; Rats, Wistar; Valine; Verapamil | 2016 |
Catch and Patch: A Pipette-Based Approach for Automating Patch Clamp That Enables Cell Selection and Fast Compound Application.
Topics: Animals; Automation; Cell Separation; Cells, Cultured; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Haloperidol; Humans; Patch-Clamp Techniques; Quinidine; Software; Structure-Activity Relationship; Time Factors; Verapamil | 2016 |
Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Dexamethasone; Digoxin; Duodenum; Ileum; Intestinal Absorption; Intestine, Small; Jejunum; Loperamide; Mice; Mice, Knockout; Proteomics; Quinidine; Verapamil; Vinblastine | 2016 |
The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo.
Topics: Adult; Aged; Aged, 80 and over; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colon; Cyclosporins; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Female; Humans; Ileum; In Vitro Techniques; Isoquinolines; Jejunum; Ketoconazole; Male; Middle Aged; Quinazolines; Quinidine; Verapamil | 2017 |
Evaluation of
Topics: Aminosalicylic Acid; Anti-Inflammatory Agents, Non-Steroidal; Antitubercular Agents; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Cimetidine; Drug Interactions; HEK293 Cells; Humans; Ibuprofen; Liver-Specific Organic Anion Transporter 1; Naproxen; Octamer Transcription Factor-1; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transporter 2; Probenecid; Proton Pump Inhibitors; Quinidine; Rifampin; Verapamil | 2017 |
Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biological Transport; Caco-2 Cells; Dogs; Humans; Kinetics; Madin Darby Canine Kidney Cells; Neoplasm Proteins; Permeability; Pharmaceutical Preparations; Quinidine; Substrate Specificity; Transfection; Verapamil | 2017 |
Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors.
Topics: Animals; Astemizole; Body Temperature; Calcium Channel Blockers; Callithrix; Electrocardiography; Flecainide; Male; Models, Animal; Quinidine; Risk Assessment; Sotalol; Telemetry; Terfenadine; Verapamil; Voltage-Gated Sodium Channel Blockers | 2019 |
Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Dabigatran; Dogs; Drug Interactions; HEK293 Cells; Humans; Inhibitory Concentration 50; Ketoconazole; Madin Darby Canine Kidney Cells; Octamer Transcription Factor-1; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; Quinidine; Renal Elimination; Transfection; Verapamil | 2019 |
Highly durable crack sensor integrated with silicone rubber cantilever for measuring cardiac contractility.
Topics: Animals; Biosensing Techniques; Dimethylpolysiloxanes; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Myocardial Contraction; Myocytes, Cardiac; Quinidine; Rats, Sprague-Dawley; Verapamil | 2020 |
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil | 2020 |
Assessment of Drug Proarrhythmic Potential in Electrically Paced Human Induced Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes Using Multielectrode Array.
Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cations, Divalent; Cell Differentiation; Humans; Induced Pluripotent Stem Cells; Ion Transport; Microelectrodes; Models, Biological; Myocardial Contraction; Myocytes, Cardiac; Nifedipine; Patch-Clamp Techniques; Phenethylamines; Primary Cell Culture; Quinidine; Sotalol; Sulfonamides; Tetrodotoxin; Verapamil | 2021 |
Physiologically-based pharmacokinetic modeling to evaluate in vitro-to-in vivo extrapolation for intestinal P-glycoprotein inhibition.
Topics: Adult; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Computer Simulation; Dabigatran; Digoxin; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Intestines; Itraconazole; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Quinidine; Verapamil; Young Adult | 2022 |
Pharmacological characterisation of electrocardiogram J-T
Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifedipine; Quinidine; Quinine; Ranolazine; Sotalol; Torsades de Pointes; Verapamil | 2022 |
An in silico-in vitro pipeline for drug cardiotoxicity screening identifies ionic pro-arrhythmia mechanisms.
Topics: Action Potentials; Arrhythmias, Cardiac; Cardiotoxicity; Cisapride; Drug Evaluation, Preclinical; HEK293 Cells; Humans; Induced Pluripotent Stem Cells; Ion Channels; Myocytes, Cardiac; Quinidine; Quinine; Verapamil | 2022 |
MEA-integrated cantilever platform for comparison of real-time change in electrophysiology and contractility of cardiomyocytes to drugs.
Topics: Animals; Biosensing Techniques; Cardiotoxicity; Cardiovascular Agents; Cells, Cultured; Induced Pluripotent Stem Cells; Ion Channels; Myocytes, Cardiac; Quinidine; Verapamil | 2022 |