verapamil has been researched along with pyrroles in 54 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (3.70) | 18.7374 |
| 1990's | 27 (50.00) | 18.2507 |
| 2000's | 17 (31.48) | 29.6817 |
| 2010's | 7 (12.96) | 24.3611 |
| 2020's | 1 (1.85) | 2.80 |
| Authors | Studies |
|---|---|
| Griffith, TM; Randall, MD | 3 |
| Huang, LJ; Huang, TF; Kuo, SC; Sun, SS; Teng, CM; Yu, SM | 1 |
| Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM | 1 |
| Taira, N; Yamagishi, T; Yanagisawa, T | 1 |
| Aghi, M; Balani, DK; Husain, Z; Imran, M; Pillai, KK; Qadry, JS | 1 |
| Arch, JR; Foster, KA; Newson, PN; Shaw, D; Taylor, SG | 1 |
| Arch, JR; Bond, J; Buckle, DR; Shaw, DJ; Taylor, JF; Taylor, SG; Ward, JS | 1 |
| Jahnecke, C; Kappes-Horn, K; Kramer, HJ; Meyer-Lehnert, H | 1 |
| Pezzola, A; Popoli, P; Sagratella, S; Scotti de Carolis, A; Zeng, YC | 1 |
| Criddle, DN; Dewar, GH; Wathey, WB; Woodward, B | 1 |
| Rampe, D; Triggle, DJ; Zheng, W | 1 |
| Barbieri, A; Grana, E; Zonta, F | 1 |
| Fromm-Freeck, S; Hayes, L; Howe, BB; Kau, ST; Kitada, S; Levin, RM; Wein, AJ | 1 |
| Bang, L; Brønsgaard, AM; Nielsen-Kudsk, JE | 1 |
| Blaustein, MP; Rubin, LJ; Tod, ML; Yuan, XJ | 1 |
| Kim, S; Koh, E; Miyashita, Y; Morimoto, S; Ogihara, T | 1 |
| Hamilton, TC; Weir, SW; Weston, AH | 1 |
| Botta, M; Bruni, G; Budriesi, R; Campiani, G; Chiarini, A; Fiorini, I; Garofalo, A; Nacci, V; Romeo, MR; Tafi, A | 1 |
| Mellemkjaer, S; Nielsen-Kudsk, JE; Thirstrup, S | 1 |
| Criddle, DN; de Moura, RS | 1 |
| Gonzalez de la Fuente, P; Marthan, R; Savineau, JP | 1 |
| Hou, YS; Lee, SS; Teng, CM; Yu, SM | 1 |
| Iwamoto, T; Morita, T; Nishimura, N; Sukamoto, T | 1 |
| Alouan, LA; Armour, CL; Black, JL; Johnson, PR; Marthan, R; McKay, KO; Savineau, JP; Tunon de Lara, JM; Villanove, X | 1 |
| Gu, H; Hagiwara, N; Momma, K; Nakanishi, T | 1 |
| Karaki, H; Mitsui-Saito, M; Ozaki, H; Trongvanichnam, K | 1 |
| Cameron, AD; Cameron, IT; Greer, IA; Martin, W; McGrath, JC; Norman, JE; Ward, LM | 1 |
| Boyd, RA; Randinitis, EJ; Reyner, EL; Stern, RH; Stewart, BH; Whitfield, L; Wu, X; Zegarac, EA | 1 |
| Stewart, BH; Whitfield, LR; Wu, X | 1 |
| Grand-Perret, T; Issandou, M | 1 |
| Blanc, E; Castex, C; Clair, P; Merida, P; Rees, AR; Temsamani, J | 1 |
| Jacobson, TA | 1 |
| Guichard, SM; Jodrell, DI; Macpherson, JS; Thurston, DE | 1 |
| Babita, K; Tiwary, AK | 1 |
| Hatipoglu, SE; Iltimur, K; Tacar, O; Tuncer, CM | 1 |
| Anglicheau, D; Beaune, P; Cassinat, B; Legendre, C; Marquet, P; Méria, P; Pallet, N; Rabant, M; Thervet, E | 1 |
| Seidler, U; Tuo, BG; Wen, GR | 1 |
| Carnes, CA; Hideg, K; Kálai, T; Khan, M; Kuppusamy, P; Kutala, VK; Mandal, R; Mohan, IK; Sridhar, A; Varadharaj, S | 1 |
| Chang, KS; Choi, DH; Choi, JS; Han, HK; Hong, SP | 1 |
| Choi, DH; Choi, JS; Shin, WG | 1 |
| Srinivas, NR | 3 |
| Baumert, C; Hilgeroth, A | 1 |
| Rao, N | 1 |
| Alfonso, S; Battilocchio, C; Biava, M; Botta, M; Buroni, S; Canseco, JO; De Logu, A; De Rossi, E; Ioerger, TR; Javid, B; La Rosa, V; Manetti, F; Pasca, MR; Poce, G; Porretta, GC; Raju, RM; Rubin, EJ; Sacchettini, JC; Sorrentino, F | 1 |
| Balganesh, M; Dinesh, N; Kuruppath, S; Nair, AV; Sharma, S; Sharma, U | 1 |
| Li, X; Liu, D; Rong, Z; Xiang, D; Xu, Y; Zhang, C | 1 |
| Benet, LZ; Estudante, M; Maya, M; Morais, JG; Soveral, G | 1 |
| Abele, D; Bickmeyer, U; Dringen, R; Petters, C; Rivera-Ingraham, G; Tietje, K | 1 |
| Chen, WC; Huang, L; Li, HY; Liu, JS; Wang, J; Yang, WD | 1 |
| Okada, H; Yasuda, K; Yoshida, A | 1 |
1 review(s) available for verapamil and pyrroles
| Article | Year |
|---|---|
Recent advances in the development of P-gp inhibitors.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Coumarins; Drug Design; Drug Resistance, Neoplasm; Flavonoids; Humans; Peptides; Propafenone; Propanolamines; Pyrazoles; Pyridines; Pyrimidines; Pyrroles; Quinazolines; Quinolines; Structure-Activity Relationship; Tamoxifen; Terpenes; Verapamil | 2009 |
3 trial(s) available for verapamil and pyrroles
| Article | Year |
|---|---|
Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion.
Topics: Adolescent; Adult; Anticholesteremic Agents; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Digoxin; Dose-Response Relationship, Drug; Drug Interactions; Female; Heptanoic Acids; Humans; Intestinal Mucosa; Male; Middle Aged; Pyrroles; Time Factors; Verapamil | 2000 |
Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.
Topics: Adolescent; Adult; Anticholesteremic Agents; Antiprotozoal Agents; Area Under Curve; Atorvastatin; Biomarkers; Calcium Channel Blockers; Clarithromycin; Creatine Kinase; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Itraconazole; Male; Mibefradil; Middle Aged; Pravastatin; Protein Synthesis Inhibitors; Pyrroles; Simvastatin; Verapamil | 2004 |
Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil.
Topics: Adult; Anticholesteremic Agents; Area Under Curve; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Drug Interactions; Heptanoic Acids; Humans; Male; Pyrroles; Verapamil | 2008 |
50 other study(ies) available for verapamil and pyrroles
| Article | Year |
|---|---|
Collateral perfusion: the role of endothelium-derived relaxing factor and effects of vasodilators.
Topics: Animals; Arginine; Benzopyrans; Collateral Circulation; Cromakalim; Ear; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pyrroles; Rabbits; Vasodilator Agents; Verapamil | 1992 |
Vasorelaxation of rat thoracic aorta caused by two Ca(2+)-channel blockers, HA-22 and HA-23.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Caffeine; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; In Vitro Techniques; Male; Nifedipine; Pyrans; Pyrazoles; Pyrroles; Rats; Rats, Inbred Strains; Vasodilation; Verapamil | 1992 |
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta, Thoracic; Benzofurans; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Quinolines; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Effects of BRL 38227, sodium nitroprusside and verapamil on collateral perfusion following acute arterial occlusion in the rabbit isolated ear.
Topics: Animals; Arginine; Arterial Occlusive Diseases; Benzopyrans; Cromakalim; Ear, External; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pyrroles; Rabbits; Regional Blood Flow; Vasodilation; Vasodilator Agents; Verapamil | 1992 |
Ca2+ influx induced by the agonist U46619 is inhibited by hyperpolarization induced by the K+ channel opener cromakalim in canine coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Dogs; Dose-Response Relationship, Drug; Female; Fluorescence; In Vitro Techniques; Male; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 1992 |
Cardioprotective effect of cromakalim (potassium channel opener) in isoproterenol induced myocardial infarction in rats.
Topics: Animals; Aspartate Aminotransferases; Benzopyrans; Blood Coagulation; Cromakalim; Female; Glycogen; Isoproterenol; L-Lactate Dehydrogenase; Leukocyte Count; Male; Myocardial Infarction; Myocardium; Pyrroles; Rats; Vasodilator Agents; Verapamil | 1992 |
Effect of Rb+ on cromakalim-induced relaxation and ion fluxes in guinea pig trachea.
Topics: Albuterol; Animals; Benzopyrans; Bronchodilator Agents; Cromakalim; Guinea Pigs; In Vitro Techniques; Isoproterenol; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Potassium; Pyrroles; Rubidium; Rubidium Radioisotopes; Trachea; Verapamil | 1992 |
The inhibitory effects of cromakalim and its active enantiomer BRL 38227 against various agonists in guinea pig and human airways: comparison with pinacidil and verapamil.
Topics: Animals; Benzopyrans; Bronchi; Bronchial Spasm; Bronchodilator Agents; Carbachol; Cromakalim; Drug Interactions; Female; Guanidines; Guinea Pigs; Humans; Male; Muscle Contraction; Pinacidil; Potassium Channels; Pyrroles; Stereoisomerism; Trachea; Vasodilator Agents; Verapamil | 1992 |
[Effects of the angiotensin converting enzyme inhibitor ramipril on calcium (Ca2+) kinetics in smooth muscle cells].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Bridged Bicyclo Compounds; Calcium; Calcium Channel Blockers; Calcium Channels; Culture Techniques; Dose-Response Relationship, Drug; Gallic Acid; Muscle, Smooth, Vascular; Pyrroles; Ramipril; Rats; Verapamil | 1991 |
Cromakalim (BRL 34915) counteracts the epileptiform activity elicited by diltiazem and verapamil in rats.
Topics: Animals; Anticonvulsants; Benzopyrans; Cromakalim; Diltiazem; Electric Stimulation; Electroencephalography; Epilepsy; Evoked Potentials; Hippocampus; In Vitro Techniques; Injections, Intraventricular; Male; Pentobarbital; Pyrroles; Rats; Rats, Inbred Strains; Synapses; Synaptic Transmission; Verapamil | 1991 |
The effects of novel vasodilator long chain acyl carnitine esters in the isolated perfused heart of the rat.
Topics: Animals; Benzopyrans; Carnitine; Coronary Circulation; Cromakalim; Dose-Response Relationship, Drug; Epoprostenol; Heart; Iloprost; In Vitro Techniques; Male; Myocardial Contraction; Nitrates; Palmitoylcarnitine; Pentanols; Pyrroles; Rats; Rats, Inbred Strains; Vasodilator Agents; Verapamil | 1990 |
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Heart; In Vitro Techniques; Isradipine; Male; Myocardium; Potassium; Pyrroles; Radioligand Assay; Rats; Vasoconstriction; Verapamil | 1991 |
Effects of cromakalim (BRL 34915) on mechanical responses of rat vas deferens to noradrenaline and naphazoline.
Topics: Animals; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Naphazoline; Norepinephrine; Parasympatholytics; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Vas Deferens; Verapamil | 1991 |
Experimental hyperreflexia: effect of intravesical administration of various agents.
Topics: Animals; Benzopyrans; Blood Pressure; Cromakalim; Diltiazem; Electric Stimulation; Electromyography; Hexamethonium Compounds; Male; Muscle Contraction; Nifedipine; Pyrroles; Rabbits; Reflex; Urinary Bladder Diseases; Vasodilator Agents; Verapamil | 1991 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Pinacidil; Pyrroles; Terbutaline; Theophylline; Trachea; Verapamil | 1990 |
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries.
Topics: Animals; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Male; Mesenteric Arteries; Potassium; Pulmonary Artery; Pyrroles; Rats; Rats, Inbred Strains; Rest; Vasoconstriction; Vasodilator Agents; Verapamil | 1990 |
Comparison of effects of a potassium channel opener BRL34915, a specific potassium ionophore valinomycin and calcium channel blockers on endothelin-induced vascular contraction.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Cromakalim; Egtazic Acid; Endothelins; Endothelium, Vascular; In Vitro Techniques; Kinetics; Muscle, Smooth, Vascular; Nicardipine; Peptides; Potassium; Potassium Channels; Pyrroles; Rats; Rats, Inbred Strains; Valinomycin; Vasoconstriction; Vasodilator Agents; Verapamil | 1989 |
Comparison of the effects of BRL 34915 and verapamil on electrical and mechanical activity in rat portal vein.
Topics: Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Portal Vein; Pyrroles; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Pyrrolo[2,1-c][1,4]benzothiazines: synthesis, structure-activity relationships, molecular modeling studies, and cardiovascular activity.
Topics: Animals; Binding, Competitive; Brain; Calcium Channel Blockers; Computer Graphics; Diltiazem; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Models, Molecular; Myocardial Contraction; Nitrendipine; Pyrroles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazines; Verapamil | 1995 |
Inhibition by cromakalim, pinacidil, terbutaline, theophylline and verapamil of non-cholinergic nerve-mediated contractions of guinea-pig isolated bronchi.
Topics: Animals; Benzopyrans; Bronchi; Bronchodilator Agents; Cromakalim; Dose-Response Relationship, Drug; Guanidines; Guinea Pigs; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Pinacidil; Potassium Channels; Pyrroles; Substance P; Synaptic Transmission; Terbutaline; Theophylline; Verapamil | 1994 |
Inhibitory effects of Rb+ on the responses to levcromakalim and P1060 in the isolated human myometrium.
Topics: Benzopyrans; Cromakalim; Female; Guanidines; Humans; In Vitro Techniques; Potassium Channels; Pyrroles; Rubidium; Uterine Contraction; Verapamil | 1995 |
Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries.
Topics: Aged; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Glyburide; Humans; Hypoxia; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Male; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Verapamil | 1995 |
Mechanisms of vasorelaxation induced by N-allylsecoboldine in rat thoracic aorta.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Thoracic; Aporphines; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphatidylinositols; Potassium; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1994 |
Differential vasorelaxant effects of K(+)-channel openers and Ca(2+)-channel blockers on canine isolated arteries.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Arteries; Benzopyrans; Calcium Channel Blockers; Cromakalim; Dogs; Female; Guanidines; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Pinacidil; Piperazines; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyrroles; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Verapamil | 1993 |
Modulation of vasodilatation to levcromakalim by hypoxia and EDRF in the rabbit isolated ear: a comparison with pinacidil, sodium nitroprusside and verapamil.
Topics: Acetylcholine; Animals; Arginine; Benzopyrans; Cromakalim; Ear, External; Guanidines; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxidative Phosphorylation; Pinacidil; Piperazines; Pyrroles; Rabbits; Receptors, N-Methyl-D-Aspartate; Regional Blood Flow; Vasodilator Agents; Verapamil | 1993 |
Sensitization decreases relaxation in human isolated airways.
Topics: Asthma; Benzopyrans; Bronchi; Bucladesine; Carbachol; Colforsin; Cromakalim; Dose-Response Relationship, Drug; Humans; Immunization, Passive; Immunoglobulin E; In Vitro Techniques; Isoproterenol; Muscle Relaxation; Muscle Tonus; Parasympatholytics; Pyrroles; Verapamil | 1993 |
Mechanisms of oxygen-induced contraction of ductus arteriosus isolated from the fetal rabbit.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Diltiazem; Ductus Arteriosus; Glyburide; In Vitro Techniques; Nickel; Norepinephrine; Oxygen; Potassium; Pyrroles; Rabbits; Vasoconstriction; Verapamil | 1993 |
Effects of chronic oral administration of levcromakalim on in vitro contractile responses of arterial smooth muscle.
Topics: Animals; Aorta; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic GMP; Dose-Response Relationship, Drug; Drug Tolerance; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nitroprusside; Potassium Channels; Pyrroles; Rats; Rats, Inbred SHR; Rats, Wistar; Vasodilator Agents; Verapamil | 1996 |
Effects of cGMP and the nitric oxide donors glyceryl trinitrate and sodium nitroprusside on contractions in vitro of isolated myometrial tissue from pregnant women.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Benzopyrans; Calcium Channel Agonists; Calcium Channel Blockers; Cromakalim; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Myometrium; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Nitroprusside; Pregnancy; Pyrroles; Uterine Contraction; Vasodilator Agents; Verapamil | 1997 |
Atorvastatin transport in the Caco-2 cell model: contributions of P-glycoprotein and the proton-monocarboxylic acid co-transporter.
Topics: Acetic Acid; Anion Transport Proteins; Antineoplastic Agents, Phytogenic; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzoic Acid; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Carbon Radioisotopes; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carboxylic Acids; Carrier Proteins; Cell Polarity; Cyclosporine; Drug Interactions; Heptanoic Acids; Humans; Hydrogen-Ion Concentration; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunosuppressive Agents; Indicators and Reagents; Ionophores; Niacin; Protons; Pyrroles; Verapamil; Vinblastine | 2000 |
Multidrug resistance P-glycoprotein is not involved in cholesterol esterification.
Topics: Acridines; Anticholesteremic Agents; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cholesterol; Cholesterol Esters; DNA-Binding Proteins; Fluoresceins; Fluorescent Dyes; Heptanoic Acids; Humans; Isoquinolines; Kinetics; Multidrug Resistance-Associated Proteins; MutS Homolog 3 Protein; Probenecid; Progesterone; Pyrroles; Sterol O-Acyltransferase; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil | 2000 |
2-Pyrrolinodoxorubicin and its peptide-vectorized form bypass multidrug resistance.
Topics: Adjuvants, Pharmaceutic; Biological Transport; Carrier Proteins; Cell Division; Cell Nucleus; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Delivery Systems; Drug Resistance, Multiple; Gene Expression; Genes, MDR; Humans; Intracellular Fluid; K562 Cells; Pyrroles; Tumor Cells, Cultured; Verapamil | 2004 |
Influence of P-glycoprotein expression on in vitro cytotoxicity and in vivo antitumour activity of the novel pyrrolobenzodiazepine dimer SJG-136.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodiazepinones; Cell Line, Tumor; Colonic Neoplasms; Drug Combinations; Humans; Immunoblotting; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Pyrroles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transplantation, Heterologous; Verapamil | 2005 |
Skin lipid synthesis inhibition: a possible means for enhancing percutaneous delivery of levodopa.
Topics: Administration, Cutaneous; Animals; Anticholesteremic Agents; Antiparkinson Agents; Atorvastatin; beta-Alanine; Calcium Channel Blockers; Calcium Chloride; Cholesterol; Dose-Response Relationship, Drug; Ethanol; Female; Heptanoic Acids; In Vitro Techniques; Levodopa; Male; Pyrroles; Rats; Rats, Wistar; Serine C-Palmitoyltransferase; Skin; Sphingosine; Time Factors; Verapamil | 2004 |
Single coronary artery with retroaortic course. An unusual origin of right Valsalva sinus.
Topics: Adult; Aspirin; Atorvastatin; Chest Pain; Coronary Vessel Anomalies; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Platelet Aggregation Inhibitors; Pyrroles; Radiography; Sinus of Valsalva; Vasodilator Agents; Verapamil | 2006 |
Role of P-glycoprotein in cyclosporine cytotoxicity in the cyclosporine-sirolimus interaction.
Topics: Acetanilides; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Culture Techniques; Cell Survival; Cells, Cultured; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Epithelial Cells; Fluorescent Dyes; Humans; Immunosuppressive Agents; Kidney; Pyrroles; Quinine; Quinolines; Rhodamines; Sirolimus; Verapamil | 2006 |
Phosphatidylinositol 3-kinase is involved in prostaglandin E2-mediated murine duodenal bicarbonate secretion.
Topics: Androstadienes; Animals; Bicarbonates; Calcium Signaling; Carbazoles; Chromones; Cyclic AMP; Dinoprostone; Duodenum; Flavonoids; Genistein; Imines; Indoles; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase Kinases; Morpholines; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Pyrroles; Signal Transduction; Sulfonamides; Verapamil; Wortmannin | 2007 |
N-hydroxy-pyrroline modification of verapamil exhibits antioxidant protection of the heart against ischemia/reperfusion-induced cardiac dysfunction without compromising its calcium antagonistic activity.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Free Radical Scavengers; In Vitro Techniques; Male; Molecular Structure; Myocardial Contraction; Myocardial Infarction; Myocardial Reperfusion Injury; Myocytes, Cardiac; Patch-Clamp Techniques; Pyrroles; Rats; Rats, Sprague-Dawley; Superoxides; Verapamil | 2007 |
Effect of atorvastatin on the intravenous and oral pharmacokinetics of verapamil in rats.
Topics: Administration, Oral; Analysis of Variance; Animals; Area Under Curve; Atorvastatin; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Half-Life; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intravenous; Male; Metabolic Clearance Rate; Pyrroles; Rats; Rats, Sprague-Dawley; Verapamil | 2008 |
Dual drug interactions via P-glycoprotein (P-gp)/ cytochrome P450 (CYP3A4) interplay: recent case study of oral atorvastatin and verapamil.
Topics: Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Heptanoic Acids; Humans; Pyrroles; Verapamil | 2008 |
Drug-drug interaction studies in preclinical species: should metabolite(s) kinetics be studied?
Topics: Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; Cytochrome P-450 CYP3A; Drug Design; Drug Interactions; Heptanoic Acids; Kinetics; Pharmacology, Clinical; Pyrroles; Verapamil | 2009 |
Efflux transporter-mediated interactions with atorvastatin--interesting findings with multiple substrates: istradefylline, verapamil, and rifampicin.
Topics: Anticholesteremic Agents; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Heptanoic Acids; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters; Purines; Pyrroles; Rifampin; Verapamil | 2009 |
Re: Efflux transporter-mediated interactions with atorvastatin--interesting findings with multiple substrates: istradefylline, verapamil, and rifampicin.
Topics: Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Organic Anion Transporters; Purines; Pyrroles; Research Design; Rifampin; Verapamil | 2011 |
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212.
Topics: Animals; Antitubercular Agents; Carbon Radioisotopes; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cattle; DNA Mutational Analysis; Drug Resistance, Multiple, Bacterial; Genome, Bacterial; Genomic Library; Humans; Membrane Transport Proteins; Microbial Sensitivity Tests; Mutation; Mycobacterium bovis; Mycobacterium Infections, Nontuberculous; Mycobacterium smegmatis; Mycobacterium tuberculosis; Piperazines; Pyrroles; Reserpine; Verapamil | 2012 |
Efflux pumps of Mycobacterium tuberculosis play a significant role in antituberculosis activity of potential drug candidates.
Topics: Antitubercular Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Culture Media; Dipeptides; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Synergism; Gene Knockout Techniques; Homologous Recombination; Humans; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Plasmids; Pyrazolones; Pyrroles; Tuberculosis, Pulmonary; Verapamil | 2012 |
Evaluation of intestinal absorption of amtolmetin guacyl in rats: breast cancer resistant protein as a primary barrier of oral bioavailability.
Topics: Adenosine; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Availability; Diketopiperazines; Glycine; Heterocyclic Compounds, 4 or More Rings; Intestinal Absorption; Intestinal Mucosa; Leukotriene Antagonists; Male; Mice; Mice, Knockout; Propionates; Pyrroles; Quinolines; Rats; Rats, Sprague-Dawley; Tolmetin; Vasodilator Agents; Verapamil | 2013 |
Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil.
Topics: Animals; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Digoxin; Heptanoic Acids; Intestinal Absorption; Pyrroles; Rats; Rats, Sprague-Dawley; Verapamil | 2013 |
Reporter dyes demonstrate functional expression of multidrug resistance proteins in the marine flatworm Macrostomum lignano: the sponge-derived dye Ageladine A is not a substrate of these transporters.
Topics: Aniline Compounds; Animals; Astrocytes; Biological Transport; Brain; Cells, Cultured; Coloring Agents; Fluoresceins; Fluorescent Dyes; Fura-2; Glutathione; Multidrug Resistance-Associated Proteins; Platyhelminths; Probenecid; Pyrroles; Rats; Rats, Wistar; Rhodamines; Verapamil; Xanthenes | 2013 |
P-glycoprotein expression in Perna viridis after exposure to Prorocentrum lima, a dinoflagellate producing DSP toxins.
Topics: Acetanilides; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Western; Cloning, Molecular; Cyclosporine; Dinoflagellida; DNA Primers; DNA, Complementary; Gills; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Perna; Pyrroles; Quinolines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Verapamil | 2014 |
Conflicting Nongenomic Effects of Progesterone in the Myometrium of Pregnant Rats.
Topics: Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Female; Hormone Antagonists; Mifepristone; Myometrium; Nifedipine; Organ Culture Techniques; Oxytocin; Potassium Chloride; Pregnancy; Progesterone; Pyrroles; Rats, Wistar; Uterine Contraction; Verapamil | 2021 |