verapamil and promethazine

verapamil has been researched along with promethazine in 26 studies

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19901 (3.85)18.7374
1990's2 (7.69)18.2507
2000's12 (46.15)29.6817
2010's11 (42.31)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Topliss, JG; Yoshida, F1
Aszalos, A; Ibrahim, S; Knapton, A; Licht, T; Peggins, J1
Alibert, S; Barbe, J; Houdoin, C; Karolak-Wojciechowska, J; Parzy, D; Pradines, B; Santelli-Rouvier, C1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Peters, JU1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Bellman, K; Knegtel, RM; Settimo, L1
Barrow, RA; Deane, KJ; Lehane, AM; Martin, RE; Summers, RL1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Khalbuss, WE; Wondergem, R1
Liu, J; Stewart, JT1
Amaral, L; Farkas, S; Gunics, G; Molnár, J; Motohashi, N1
Demajo, M; Horvat, A; Momić, T; Nikezić, G; Petrović, S1
Gbotosho, GO; Gerena, L; Happi, CT; Kyle, DE; Milhous, WK; Oduola, AM; Ogundahunsi, OA; Salako, LA; Sowunmi, A1
Akhmetova, L; Dönmez, Y; Gündüz, U; İşeri, ÖD; Kars, MD1
Furutani, K; Inanobe, A; Kurachi, Y; Ohno, Y; Yamakawa, Y1
Caprioli, RM; Chumbley, CW; Hachey, BC; Norris, JL; Prentice, BM1

Reviews

2 review(s) available for verapamil and promethazine

ArticleYear
Polypharmacology - foe or friend?
    Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22

    Topics: Animals; Communicable Diseases; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Polypharmacology; Safety

2013
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Other Studies

24 other study(ies) available for verapamil and promethazine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Influence of antipsychotic, antiemetic, and Ca(2+) channel blocker drugs on the cellular accumulation of the anticancer drug daunorubicin: P-glycoprotein modulation.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 295, Issue:3

    Topics: 3T3 Cells; Animals; Antibiotics, Antineoplastic; Antiemetics; Antipsychotic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Calcium Channel Blockers; Daunorubicin; Flow Cytometry; Humans; Mice; Transfection

2000
Synthesis and effects on chloroquine susceptibility in Plasmodium falciparum of a series of new dihydroanthracene derivatives.
    Journal of medicinal chemistry, 2002, Jul-18, Volume: 45, Issue:15

    Topics: Animals; Anthracenes; Antimalarials; Chloroquine; CHO Cells; Cricetinae; Drug Resistance, Multiple; Erythrocytes; In Vitro Techniques; Models, Molecular; Plasmodium falciparum; Structure-Activity Relationship

2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT.
    ACS medicinal chemistry letters, 2014, May-08, Volume: 5, Issue:5

    Topics:

2014
Involvement of cell calcium and transmembrane potential in control of hepatocyte volume.
    Hepatology (Baltimore, Md.), 1991, Volume: 13, Issue:5

    Topics: Animals; Calcium; Calmodulin; Colchicine; Culture Techniques; Cytochalasin B; Cytoskeleton; Dose-Response Relationship, Drug; Liver; Male; Membrane Potentials; Mice; Mice, Inbred ICR; Microelectrodes; Osmolar Concentration; Osmotic Pressure; Promethazine; Trifluoperazine; Verapamil

1991
Quantitation of promethazine enantiomers in human serum using a chiralcel OJ-R column and mixed-mode disc solid-phase extraction.
    Journal of pharmaceutical and biomedical analysis, 1997, Volume: 16, Issue:2

    Topics: Anti-Allergic Agents; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Humans; Promethazine; Verapamil

1997
Interaction between antibiotics and non-conventional antibiotics on bacteria.
    International journal of antimicrobial agents, 2000, Volume: 14, Issue:3

    Topics: Ampicillin; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Antipruritics; Bacteria; Calcium Channel Blockers; Clomipramine; Drug Combinations; Drug Interactions; Drug Resistance, Microbial; Erythromycin; Escherichia coli; Gentamicins; Humans; Methylene Blue; Promethazine; Pseudomonas aeruginosa; Selective Serotonin Reuptake Inhibitors; Staphylococcus epidermidis; Tetracycline; Verapamil

2000
Selective inhibition of brain Na,K-ATPase by drugs.
    Physiological research, 2006, Volume: 55, Issue:3

    Topics: Adenosine Triphosphate; Animals; Brain; Cell Membrane; Dose-Response Relationship, Drug; Enzyme Inhibitors; Kinetics; Male; Medigoxin; Promethazine; Propranolol; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase; Swine; Synaptosomes; Verapamil

2006
The effects of alpha1-acid glycoprotein on the reversal of chloroquine resistance in Plasmodium falciparum.
    Annals of tropical medicine and parasitology, 2006, Volume: 100, Issue:7

    Topics: Animals; Antimalarials; Calcium Channel Blockers; Chloroquine; Chlorpheniramine; Desipramine; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Enzyme Inhibitors; Histamine H1 Antagonists; Orosomucoid; Plasmodium falciparum; Promethazine; Verapamil

2006
Effect of MDR modulators verapamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells.
    Cancer chemotherapy and pharmacology, 2011, Volume: 67, Issue:4

    Topics: Antibiotics, Antineoplastic; Biological Transport; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Microscopy, Confocal; Multidrug Resistance-Associated Proteins; Polymerase Chain Reaction; Promethazine; RNA; Verapamil

2011
Pharmacophore modeling for hERG channel facilitation.
    Biochemical and biophysical research communications, 2012, Feb-03, Volume: 418, Issue:1

    Topics: Animals; Atenolol; Chlorpheniramine; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoxetine; Haloperidol; Humans; Hydrophobic and Hydrophilic Interactions; Imipramine; Metoprolol; Nortriptyline; Potassium Channel Blockers; Promethazine; Propranolol; Quantitative Structure-Activity Relationship; Sotalol; Terfenadine; Verapamil; Xenopus laevis

2012
Multiple Time-of-Flight/Time-of-Flight Events in a Single Laser Shot for Improved Matrix-Assisted Laser Desorption/Ionization Tandem Mass Spectrometry Quantification.
    Analytical chemistry, 2016, 10-04, Volume: 88, Issue:19

    Topics: Antihypertensive Agents; Enalapril; Humans; Lasers; Molecular Structure; Promethazine; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Verapamil

2016