verapamil has been researched along with prazosin in 138 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 47 (34.06) | 18.7374 |
| 1990's | 46 (33.33) | 18.2507 |
| 2000's | 23 (16.67) | 29.6817 |
| 2010's | 20 (14.49) | 24.3611 |
| 2020's | 2 (1.45) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Sen, S; Sinha, N | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Adile, AA; Bakhshinyan, D; Berger-Becvar, A; de Araujo, ED; Deininger, MW; Fishel, ML; Gawel, JM; Geletu, M; Grimard, ML; Gunning, PT; Heaton, WL; Konieczny, SF; Luchman, HA; O'Hare, T; Raouf, YS; Shah, F; Shouksmith, AE; Singh, SK; Venugopal, C; Weiss, S | 1 |
| Esaki, T; Kawashima, H; Komura, H; Kuroda, M; Mizuguchi, K; Natsume-Kitatani, Y; Ohashi, R; Watanabe, R | 1 |
| Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
| Andersson, KE; Mikkelsen, E | 1 |
| Naito, M; Oh-hara, T; Sugawara, I; Tatsuta, T; Tsuruo, T | 1 |
| Akaike, M; Hirai, M; Kumai, T; Masubuchi, Y; Tanaka, M; Watanabe, M | 1 |
| Gagało, IT; Hać, EE; Szreder, Z | 1 |
| Tenjarla, SN; Tseggai, A | 1 |
| Elliott, HL; Meredith, PA | 1 |
| Amobi, NI; Smith, IC | 1 |
| Holmes, PH; Mounsey, A; Sutherland, IA | 1 |
| Hiraoka, I; Oka, H; Oshita, S; Takeshita, H | 1 |
| García-Barrado, MJ; Moratinos, J; Reverte, M | 1 |
| Pool, JL | 1 |
| Braver-Chernobul'skaia, BS; Gorchakova, NA; Lebed', OI; Shevchuk, VG; Zhirnov, VV; Zueva, NA | 1 |
| Shimizu, M; Yamawaki, S | 1 |
| Altmann, O | 1 |
| Gong, MC; Kobayashi, S; Somlyo, AP; Somlyo, AV | 1 |
| Gindin, E; Greenberger, LM; Horwitz, SB; Yang, CP | 1 |
| Hsu, WH; Ko, JC; Smith, BE | 1 |
| Butler, BT; Collins, R; Piascik, MT | 1 |
| Endoh, M; Hiramoto, T; Kushida, H | 1 |
| Bray, M; Smith, IC | 1 |
| Bennett, T; Mangroo, T; Neves, M; Rahmani, MA | 1 |
| Louis, WJ; Rand, MJ; Tung, LH | 1 |
| Elliott, HL; Meredith, PA; Pasanisi, F; Reid, JL | 1 |
| Colucci, WS; Powers, RE | 1 |
| Louis, WJ; Rand, MJ; Story, DF; Tung, LH | 1 |
| Bognar, IT; Enero, MA | 1 |
| Elliott, HL; Meredith, PA; Reid, JL | 1 |
| Gomi, Y; Suzuki, N | 1 |
| Lortet, S; Zimmer, HG | 1 |
| Barr, SM; Hamilton, CA; Reid, JL | 1 |
| Zierhut, W; Zimmer, HG | 1 |
| Feller, DR; Hamada, A; Miller, DD; Patil, PN; Shams, G; Venkataraman, BV | 1 |
| Marion, DN; Peterson, M; Rubattu, S; Sealey, JE | 1 |
| Conti, CR | 1 |
| Moulds, RF | 1 |
| Erecińska, M; Nuutinen, EM; Wilson, DF | 1 |
| Guimarães, S; Moura, D; Paiva, MQ | 1 |
| Chiu, AT; Miller, CR; Thoolen, MJ; Timmermans, PB | 1 |
| Biery, D; LeVeen, RF; Wolf, GL | 1 |
| Fujiwara, M; Muramatsu, I | 1 |
| Akopian, LM; Basem, AS; Ivleva, AIa; Krasnobaeva, GM; Moiseev, VS | 1 |
| O'Hara, N; Ono, H | 1 |
| Fukuda, H; Ishida, Y; Iwamoto, T; Kanaya, J; Maeshiba, Y; Moritoki, H | 1 |
| Das, PK; Mishra, SK; Sanyal, AK | 1 |
| Campbell, L; Elliott, HL; Meredith, PA; Reid, JL | 1 |
| Cashman, PM; Gould, BA; Hornung, RS; Kieso, H; Raftery, EB | 1 |
| Schwartz, PJ; Vanoli, E | 1 |
| Bolger, GT; Crawley, JN; Paul, SM; Rafferty, MF; Skolnick, P | 1 |
| Elson, EL; Goligorsky, MS; Hruska, KA; Loftus, DJ | 1 |
| Gaba, DM; Maze, M; Metz, S | 1 |
| Fairfax, CA; Tanz, RD | 1 |
| Buckalew, VM; Strandhoy, JW; Wolff, DW | 2 |
| Aliperta, A; Catena, E; Giordano, L; Lampa, E; Marmo, E; Perna, D; Rossi, F | 1 |
| Anand, MP | 1 |
| Pedrinelli, R; Tarazi, RC | 1 |
| Beckeringh, JJ; de Jonge, A; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B | 1 |
| Hano, T; Kuchii, M; Kusuyama, Y; Masuyama, Y; Nishio, I; Tsuda, K | 1 |
| Piotrovskii, VK | 1 |
| Hirakawa, S; Ito, H | 1 |
| Glossmann, H; Hornung, R | 1 |
| Birkenhäger, WH; de Leeuw, PW; van Soest, GA | 1 |
| Bolli, P; Bühler, FR; Erne, P; Kiowski, W; Müller, FB | 1 |
| Elliott, HL; McSharry, DR; Meredith, PA; Pasanisi, F; Reid, JL | 1 |
| Downing, OA; Louttit, JB; Wilson, KA | 1 |
| Chihara, S; Kishimoto, T; Ozaki, H; Umeno, H; Urakawa, N | 1 |
| Bosnić, O; Cvetković, M; Macut, DJ; Mihajlović, M; Nesić, M; Pavlović, M; Petković, D; Radulović, R; Zdjelar, K | 1 |
| Chen, YH; Tsai, MC | 1 |
| Elliott, WJ | 1 |
| Johnston, W; Laddu, AR; Lenz, ML; Pool, JL; Taylor, AA; Varghese, A | 1 |
| Alvarez, TA; Keller, PA; Konkol, RJ; Madden, JA | 1 |
| Battell, ML; Grassby, PF; Lee, SY; McNeill, JH; Rodrigues, B | 1 |
| Li, ZH; Liu, SF; Wang, GL; Zhang, SS | 1 |
| Hsu, WH; Shin, DH | 1 |
| Lasova, LS; Mutafova-Yambolieva, VN; Venkova, KM | 1 |
| Matlib, MA; Motley, ED; Paul, RJ | 1 |
| Batrak, GN; Degtiar, VY; Hawryluk, BR; Luik, AI; Mogilevich, SE; Naydyenova, IY; Prokopenko, RA | 1 |
| Brown, DR; Malone, ED; Trent, AM; Turner, TA | 1 |
| Bilezikian, JP; Braunstein, V; Chen, B; Christ, GJ; Huang, H; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M | 1 |
| Ambudkar, SV; Gottesman, MM; Hrycyna, CA; Pastan, I; Ramachandra, M | 1 |
| Gertner, SB; Hey, JA; McLeod, RL | 1 |
| Chung, R; Cowman, AF; Foley, M; Riffkin, CD; Tilley, L; Wall, DM; Zalcberg, JR | 1 |
| Chen, G; Dumontet, C; Durán, GE; Jaffrézou, JP; Lacayo, NJ; Sikic, BI; Steger, KA | 1 |
| Marwood, JF; Okoro, EO | 1 |
| Wong, KK | 1 |
| Béliveau, R; Jetté, L; Murphy, GF | 1 |
| Airan, LE; Ambudkar, SV; Germann, UA; Gottesman, MM; Hrycyna, CA; Pastan, I | 1 |
| Borda, E; Busch, L; Wald, M | 1 |
| Diéguez, G; Fernández, N; García-Villalón, AL; Gómez, B; Monge, L; Padilla, J; Sánchez, MA | 1 |
| Dey, S; Gottesman, MM; Hafkemeyer, P; Pastan, I | 1 |
| Cheng, PW; Germann, UA; Gottesman, MM; Hrycyna, CA; Pastan, I; Ramachandra, M | 1 |
| Eckert, RE; Karsten, AJ; Utz, J; Ziegler, M | 1 |
| Boselli, C; Grana, E | 1 |
| Atucha, NM; Fortepiani, LA; García-Estañ, J; Nadal, FJ; Ortíz, MC; Ruiz-Marcos, FM | 1 |
| Bates, SE; Honjo, Y; Litman, T; Miyake, K; Regis, JT; Robey, RW; van de Laar, A | 1 |
| Melera, PW; Song, J | 2 |
| Elliott, JI; Higgins, CF; Raguz, S | 1 |
| Chattopadhyay, A; Dey, S; Fong, WF; Shen, XL; Wan, CK; Zhu, GY | 1 |
| Ambudkar, SV; Barnett, D; Bates, SE; Finley, EM; Fojo, T; Oldham, RK; Robey, RW; Shukla, S | 1 |
| Chmielewski, J; Emmert, D; Hrycyna, CA; Pires, MM | 1 |
| Booth-Genthe, CL; Gupta, A; Harris, J; Unadkat, JD; Zolnerciks, JK | 1 |
| Bernstein, D; Berry, G; Fajardo, G; Mochly-Rosen, D; Wong, LJ; Zhao, M | 1 |
| Coleman, T; Haslam, IS; Simmons, NL; Wright, JA | 1 |
| Büyüknacar, HS; de Groat, WC; Ertuğ, PU; Eser, N; Göçmen, C; Kumcu, EK; Onder, S | 1 |
| Habicht, KL; Khadeer, MA; Moaddel, R; Shimmo, R; Singh, NS; Wainer, IW | 1 |
| Chaudhry, B; Egginton, S; Glen, KE; Hall-Jones, J; Hussain, A; Syeda, F | 1 |
| Abel, B; Ambudkar, SV; Durell, SR; Jacobson, KA; Murakami, M; Tosh, DK; Vahedi, S | 1 |
5 review(s) available for verapamil and prazosin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diuretics; Humans; Hypertension; Prazosin; Verapamil | 1991 |
New drugs for hypertension--variations on old themes.
Topics: Amlodipine; Antihypertensive Agents; Delayed-Action Preparations; Dihydropyridines; Doxazosin; Humans; Hypertension; Isradipine; Nifedipine; Prazosin; Verapamil | 1991 |
Large vessel coronary vasospasm: diagnosis, natural history and treatment.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aspirin; Coronary Artery Bypass; Coronary Disease; Coronary Vasospasm; Diltiazem; Electrocardiography; Epoprostenol; Female; Fibrinolytic Agents; Humans; Isosorbide Dinitrate; Male; Nifedipine; Nitrates; Prazosin; Verapamil | 1985 |
Hypertension--drug management.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Calcium Channel Blockers; Captopril; Diazoxide; Humans; Hypertension; Indoramin; Labetalol; Minoxidil; Nifedipine; Nitroprusside; Prazosin; Sympatholytics; Vasodilator Agents; Verapamil | 1982 |
7 trial(s) available for verapamil and prazosin
| Article | Year |
|---|---|
Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diuretics; Humans; Hypertension; Prazosin; Verapamil | 1991 |
Clinical pharmacological studies on the interaction between alpha-adrenoceptors and calcium antagonists.
Topics: Angiotensin II; Blood Pressure; Calcium Channel Blockers; Double-Blind Method; Humans; Male; Nordefrin; Phenylephrine; Posture; Prazosin; Receptors, Adrenergic, alpha; Vasoconstriction; Vasomotor System; Verapamil | 1985 |
Verapamil and prazosin in essential hypertension: evidence of a synergistic combination?
Topics: Adult; Biological Availability; Blood Pressure; Drug Synergism; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Prazosin; Random Allocation; Verapamil | 1987 |
The combination of prazosin and verapamil in the treatment of essential hypertension.
Topics: Adult; Aldosterone; Blood Pressure; Catecholamines; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Prazosin; Renin; Verapamil | 1988 |
An evaluation of self-recorded blood pressure during drug trials.
Topics: Adult; Aged; Blood Pressure; Blood Pressure Determination; Clinical Trials as Topic; Evaluation Studies as Topic; Female; Humans; Hypertension; Male; Middle Aged; Prazosin; Verapamil | 1986 |
Combined terazosin and verapamil therapy in essential hypertension. Hemodynamic and pharmacokinetic interactions.
Topics: Adult; Blood Pressure; Double-Blind Method; Drug Therapy, Combination; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Posture; Prazosin; Verapamil | 1995 |
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Factors; Biological Transport; Cell Line; Cell Line, Tumor; Cyclosporins; Depsipeptides; Fluorescent Dyes; Fluorouracil; Humans; Insecta; Multidrug Resistance-Associated Proteins; Neoplasms; Paclitaxel; Prazosin; Quinolines; Rhodamine 123; Verapamil; Vinblastine | 2008 |
127 other study(ies) available for verapamil and prazosin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.
Topics: Animals; Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Disease Models, Animal; Histone Deacetylase Inhibitors; Humans; Hydrocarbons, Fluorinated; Hydroxamic Acids; Mice; Pancreatic Neoplasms; Sulfonamides | 2019 |
Development of an
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Cell Line; Computer Simulation; Endothelial Cells; Gene Knockout Techniques; Humans; Organic Chemicals; Rats, Transgenic | 2021 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
Contractile effects of prostaglandin F2alpha on isolated human peripheral arteries and veins.
Topics: Adult; Aged; Arteries; Calcium; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Nifedipine; Norepinephrine; Phentolamine; Potassium; Prazosin; Prostaglandins F; Time Factors; Veins; Verapamil | 1978 |
Functional involvement of P-glycoprotein in blood-brain barrier.
Topics: Alkaline Phosphatase; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blood-Brain Barrier; Brain; Capillaries; Cells, Cultured; Drug Interactions; Endothelium, Vascular; gamma-Glutamyltransferase; Humans; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Immunoelectron; Prazosin; Tumor Cells, Cultured; Verapamil; Vincristine | 1992 |
Disturbance or relatively important actions of antihypertensives, antifungal agent and opiate antagonist to the testicular steroidogenesis in rat.
Topics: Androstenedione; Animals; Antifungal Agents; Antihypertensive Agents; Clonidine; Estradiol; Ketoconazole; Male; Naloxone; Narcotic Antagonists; Prazosin; Rats; Testis; Testosterone; Verapamil | 1992 |
A comparative study on the effect of verapamil and prazosin on the thermoregulatory responses induced by cold or exogenous noradrenaline.
Topics: Animals; Body Temperature Regulation; Cold Temperature; Female; Male; Norepinephrine; Prazosin; Rabbits; Verapamil | 1992 |
High-performance liquid chromatographic assay of prazosin for transdermal screening studies.
Topics: Chromatography, High Pressure Liquid; Humans; Prazosin; Skin; Skin Absorption; Verapamil | 1992 |
An additive or synergistic drug interaction: application of concentration-effect modeling.
Topics: Adult; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Humans; Hypotension; Male; Models, Biological; Prazosin; Verapamil | 1992 |
Effects of thioridazine on mechanical responses of human vas deferens induced by noradrenaline or potassium.
Topics: Culture Techniques; Diltiazem; Humans; Male; Muscle Contraction; Norepinephrine; Phentolamine; Potassium; Prazosin; Thioridazine; Vas Deferens; Verapamil | 1992 |
Transport of isometamidium (Samorin) by drug-resistant and drug-sensitive Trypanosoma congolense.
Topics: Animals; Biological Transport, Active; Desipramine; Drug Resistance; Glycerol; Hydrogen-Ion Concentration; Kinetics; Phenanthridines; Polysorbates; Prazosin; Salicylamides; Temperature; Trypanocidal Agents; Trypanosoma congolense; Verapamil | 1992 |
Halothane increases epinephrine threshold for the development of slow responses in isolated canine trabeculae.
Topics: Animals; Calcium Channels; Connective Tissue; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Epinephrine; Female; Halothane; Heart; Male; Metoprolol; Prazosin; Verapamil | 1991 |
Role of alpha-adrenoceptors in control of plasma potassium in conscious rabbits.
Topics: Animals; Apamin; Calcium Channels; Clonidine; Dioxanes; Ethanolamines; Hyperkalemia; Idazoxan; Potassium; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Verapamil | 1991 |
[Structural effects in the sarcolemma of the cardiomyocytes under the action of modulators of the polyphosphoinositide system].
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Cattle; Fluorescent Dyes; Heart; In Vitro Techniques; Myocardium; N-Formylmethionine Leucyl-Phenylalanine; Phosphatidylinositol Phosphates; Phosphatidylinositols; Prazosin; Sarcolemma; Verapamil | 1990 |
Effects of Ca2+ antagonists on NA-induced intracellular Ca2+ mobilization in rat cultured neurons.
Topics: Animals; Calcium; Cells, Cultured; Diltiazem; Frontal Lobe; Intracellular Fluid; Neurons; Nicardipine; Norepinephrine; Prazosin; Rats; Verapamil | 1991 |
[Pharmacological lowering of portal pressure in normal rats and in experimental liver cirrhosis].
Topics: Acute Disease; Animals; Blood Pressure; Canrenoic Acid; Heart Rate; Hypertension, Portal; Liver Cirrhosis, Experimental; Male; Portal System; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Verapamil | 1991 |
Ca2+ channel blockers distinguish between G protein-coupled pharmacomechanical Ca2+ release and Ca2+ sensitization.
Topics: Animals; Calcimycin; Calcium; Calcium Channel Blockers; Egtazic Acid; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Guinea Pigs; In Vitro Techniques; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Phenylephrine; Portal Vein; Prazosin; Verapamil | 1991 |
Photoaffinity probes for the alpha 1-adrenergic receptor and the calcium channel bind to a common domain in P-glycoprotein.
Topics: Affinity Labels; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Binding, Competitive; Calcium Channels; Cell Line; Cell Membrane; Chymotrypsin; Dihydropyridines; Drug Resistance; Macrophages; Membrane Glycoproteins; Mice; Peptide Mapping; Prazosin; Receptors, Adrenergic, alpha; Sequence Homology, Nucleic Acid; Verapamil | 1990 |
Xylazine enhances porcine myometrial contractility in vitro: possible involvement of alpha 2-adrenoceptors and Ca2+ channels.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium Channels; Carbachol; Dioxanes; Female; Idazoxan; Myometrium; Prazosin; Receptors, Adrenergic, alpha; Swine; Uterine Contraction; Verapamil; Xylazine; Yohimbine | 1990 |
Stereoselective and nonstereoselective inhibition exhibited by the enantiomers of verapamil.
Topics: Anesthesia; Animals; Blood Pressure; Brain; Calcium Channels; In Vitro Techniques; Membranes; Muscle Contraction; Muscle, Smooth, Vascular; Potassium Chloride; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Stereoisomerism; Verapamil | 1990 |
The preferential inhibition of alpha 1- over beta-adrenoceptor-mediated positive inotropic effect by organic calcium antagonists in the rabbit papillary muscle.
Topics: Animals; Calcium; Calcium Channel Blockers; Diltiazem; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardium; Nifedipine; Papillary Muscles; Prazosin; Rabbits; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Subcellular Fractions; Verapamil | 1990 |
Direct and indirect contractile responses of the human vas deferens and actions of noradrenaline and of calcium antagonists.
Topics: Calcium; Calcium Channel Blockers; Electric Stimulation; Humans; Male; Muscle Contraction; Nifedipine; Norepinephrine; Prazosin; Tetrodotoxin; Vas Deferens; Verapamil | 1990 |
In vitro caffeine induced aortic smooth muscle reactivity in rat.
Topics: Animals; Aorta; Caffeine; Hypertension; In Vitro Techniques; Magnesium; Male; Muscle, Smooth, Vascular; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Vasoconstriction; Vasodilation; Verapamil; Yohimbine | 1990 |
Cardiac alpha-adrenoceptors involving positive chronotropic responses.
Topics: Animals; Calcium; Heart; Heart Rate; Male; Prazosin; Propranolol; Rats; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Verapamil | 1985 |
An increase in putative voltage dependent calcium channel number following reserpine treatment.
Topics: Animals; Catecholamines; Ion Channels; Male; Membrane Potentials; Muscle, Smooth; Nifedipine; Nitrendipine; Prazosin; Rats; Receptors, Adrenergic, alpha; Reserpine; Seminal Vesicles; Verapamil | 1985 |
Cardiac alpha-adrenoceptors: postjunctional and prejunctional.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Antagonists; Animals; Calcium; Dioxanes; Dose-Response Relationship, Drug; Female; Heart Conduction System; Heart Rate; Idazoxan; In Vitro Techniques; Labetalol; Methoxamine; Myocardial Contraction; Myocardium; Norepinephrine; Phenylephrine; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Stimulation, Chemical; Verapamil | 1986 |
Influence of a receptor reserve on the inhibition by calcium channel blockers of alpha adrenoceptor-mediated responses in rat isolated vascular tissues.
Topics: Animals; Aorta, Thoracic; Calcium; Female; In Vitro Techniques; Ion Channels; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Perfusion; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Verapamil; Yohimbine | 1988 |
Effects of calcium-entry modulators on the biphasic neurogenic contractions in the circular muscle of guinea pig vas deferens.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Norepinephrine; Prazosin; Vas Deferens; Verapamil | 1989 |
Functional and metabolic effects of ribose in combination with prazosin, verapamil and metoprolol in rats in vivo.
Topics: Adenine Nucleotides; Animals; Drug Interactions; Energy Metabolism; Heart; Hemodynamics; Metoprolol; Muscles; Myocardium; Phosphoribosyl Pyrophosphate; Prazosin; Rats; Rats, Inbred Strains; Ribose; Verapamil; Viscera | 1989 |
Platelet cytosolic free calcium before and after antihypertensive treatment in perinephritis hypertension of the rabbit.
Topics: Adrenergic alpha-Agonists; Animals; Blood Platelets; Blood Pressure; Calcium; Calcium Channels; Cytosol; Heart Rate; Hypertension, Renal; Male; Platelet Aggregation; Prazosin; Rabbits; Stimulation, Chemical; Verapamil | 1989 |
Significance of myocardial alpha- and beta-adrenoceptors in catecholamine-induced cardiac hypertrophy.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Cardiomegaly; DNA; Female; Myocardium; Norepinephrine; Osmolar Concentration; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Vascular Resistance; Verapamil | 1989 |
Paradoxical effects of isothiocyanate analog of tolazoline on rat aorta and human platelets.
Topics: Adrenergic alpha-Antagonists; Animals; Aorta; Atrial Function; Benzazepines; Blood Platelets; Calcium; Carbachol; Dose-Response Relationship, Drug; Epinephrine; Female; Guinea Pigs; Heart Atria; Isoproterenol; Isothiocyanates; Male; Nifedipine; Phenoxybenzamine; Phentolamine; Phenylephrine; Platelet Activation; Platelet Aggregation; Prazosin; Rats; Rats, Inbred Strains; Temperature; Thiocyanates; Tolazoline; Trachea; Vasoconstriction; Verapamil; Yohimbine | 1989 |
Dexamethasone-inhibitable stimulation of plasma prorenin by ketamine in cats.
Topics: Animals; Cats; Dexamethasone; Enzyme Precursors; Female; Ketamine; Kinetics; Male; Prazosin; Renin; Verapamil | 1989 |
Clinical pharmacology of vasodilator drugs.
Topics: Adrenergic alpha-Antagonists; Calcium Channel Blockers; Coronary Disease; Humans; Hydralazine; Hypertension; Isosorbide Dinitrate; Kinetics; Liver; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Prazosin; Vasodilator Agents; Verapamil | 1985 |
The effect of cholinergic agonists on coronary flow rate and oxygen consumption in isolated perfused rat heart.
Topics: Animals; Bethanechol; Bethanechol Compounds; Calcium; Carbachol; Cardiac Pacing, Artificial; Choline; Coronary Circulation; Dose-Response Relationship, Drug; Energy Metabolism; Heart Rate; Male; Myocardium; Oxygen Consumption; Perfusion; Prazosin; Propranolol; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Verapamil | 1985 |
Alpha 2-adrenoceptor-mediated responses to so-called selective alpha 1-adrenoceptor agonists after partial blockade of alpha 1-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Dogs; Drug Interactions; In Vitro Techniques; Methoxamine; Muscle Contraction; Muscle, Smooth, Vascular; Phenoxybenzamine; Phenylephrine; Prazosin; Quinoxalines; Receptors, Adrenergic, alpha; Verapamil; Yohimbine | 1987 |
Effect of calcium entry blockers on blood pressure and vasoconstrictor responses to alpha-1 adrenoceptor stimulation in conscious spontaneously hypertensive rats.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Binding, Competitive; Blood Pressure; Brain; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Injections, Intravenous; Male; Nifedipine; Prazosin; Propylamines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Stimulation, Chemical; Tiapamil Hydrochloride; Tritium; Vasoconstrictor Agents; Verapamil | 1987 |
Angioplasty-induced vasospasm in rabbit model. Mechanisms and treatment.
Topics: Angioplasty, Balloon; Animals; Extravasation of Diagnostic and Therapeutic Materials; Femoral Artery; Heparin; Iliac Artery; Imidazoles; Male; Prazosin; Rabbits; Radiography; Spasm; Thrombosis; Vascular Diseases; Verapamil | 1985 |
[Vasorelaxing action of nicorandil, in comparison with nitroglycerin and Ca antagonists].
Topics: Animals; Aorta; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Drug Interactions; Male; Niacinamide; Nicorandil; Nitroglycerin; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Vasodilator Agents; Verapamil | 1986 |
[Hemodynamic effect of a combination of prazosin with cardiac depressants in the treatment of hypertension].
Topics: Anti-Arrhythmia Agents; Celiprolol; Clonidine; Drug Evaluation; Drug Synergism; Drug Therapy, Combination; Female; Hemodynamics; Humans; Hypertension; Male; Prazosin; Propanolamines; Propranolol; Verapamil | 1988 |
Papaverine inhibits binding of [3H]-prazosin and [3H]-yohimbine to rat renal cortical membranes.
Topics: Animals; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Kidney Cortex; Kinetics; Male; Norepinephrine; Papaverine; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Tritium; Verapamil; Yohimbine | 1986 |
Verapamil enhances the non-adrenergic twitch response of rat vas deferens.
Topics: Animals; Autonomic Nervous System; Electric Stimulation; Gallopamil; Hydroxydopamines; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Oxidopamine; Prazosin; Rats; Reserpine; Vas Deferens; Verapamil; Yohimbine | 1987 |
Sodium-depletion-induced contractures in isolated rat vas deferens: possible role of endogenous catecholamines.
Topics: Animals; Barium; Barium Compounds; Chlorides; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Prazosin; Rats; Reference Values; Reserpine; Sodium; Vas Deferens; Verapamil | 1988 |
An experimental approach to the choice of antiarrhythmic therapy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil | 1986 |
Effects of calcium antagonists on phencyclidine behaviors.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Drug Interactions; Male; Mice; Motor Activity; Motor Skills; Nifedipine; Phencyclidine; Prazosin; Pyridines; Verapamil | 1986 |
Alpha 1-adrenergic stimulation and cytoplasmic free calcium concentration in cultured renal proximal tubular cells: evidence for compartmentalization of quin-2 and fura-2.
Topics: Aminoquinolines; Animals; Benzofurans; Calcium; Cell Compartmentation; Cells, Cultured; Cytoplasm; Dogs; Female; Fura-2; Isoquinolines; Kidney Tubules, Proximal; Male; Phenylephrine; Pinocytosis; Prazosin; Verapamil | 1986 |
Postcountershock myocardial damage after pretreatment with adrenergic and calcium channel antagonists in halothane-anesthetized dogs.
Topics: Anesthesia, Inhalation; Animals; Calcium Channel Blockers; Dogs; Electric Countershock; Female; Halothane; Heart; Male; Metoprolol; Myocardium; Necrosis; Prazosin; Radionuclide Imaging; Sympatholytics; Technetium; Technetium Tc 99m Pyrophosphate; Tin Polyphosphates; Verapamil | 1985 |
Insurmountable antagonism of ouabain-induced coronary constriction by prazosin.
Topics: Animals; Coronary Vessels; In Vitro Techniques; Ouabain; Prazosin; Quinazolines; Swine; Vasoconstriction; Verapamil | 1985 |
Renal alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in dogs: comparison of phenylephrine, clonidine, and guanabenz.
Topics: Animals; Calcium; Clonidine; Denervation; Dogs; Drug Interactions; Female; Guanabenz; Guanidines; Kidney; Male; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha; Renal Circulation; Vasoconstriction; Verapamil; Yohimbine | 1984 |
Renal alpha 1- and alpha 2-adrenoceptor mediated vasoconstriction in dogs.
Topics: Animals; Calcium; Clonidine; Dogs; Dose-Response Relationship, Drug; Guanabenz; Kidney; Phenylephrine; Prazosin; Receptors, Adrenergic, alpha; Renal Circulation; Vasoconstriction; Verapamil; Yohimbine | 1984 |
A study on the effects of some drugs on DOCA induced hypertension in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Diuretics; Hypertension; Indoramin; Male; Metoprolol; Prazosin; Pulmonary Artery; Rats; Verapamil | 1980 |
Interference of calcium entry blockade in vivo with pressor responses to alpha-adrenergic stimulation: effects of two unrelated blockers on responses to both exogenous and endogenously released norepinephrine.
Topics: Adrenergic alpha-Agonists; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electric Stimulation; Female; Nifedipine; Nitrendipine; Norepinephrine; Prazosin; Rats; Rats, Inbred Strains; Vasoconstriction; Verapamil; Yohimbine | 1984 |
Differential effects of the calcium entry blocker D 600 on contractions of rat and guinea-pig aortas, elicited by various alpha-1 adrenoceptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Aorta; Calcium; Dose-Response Relationship, Drug; Gallopamil; Guinea Pigs; In Vitro Techniques; Male; Prazosin; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Species Specificity; Vasoconstriction; Verapamil; Yohimbine | 1984 |
Neurotransmitter release and vascular reactivity in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Calcium; Catecholamines; Electric Stimulation; Guanethidine; Hypertension; Male; Mesenteric Arteries; Neurotransmitter Agents; Norepinephrine; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System; Vasoconstriction; Verapamil | 1984 |
On the usefulness of ultrafiltration in drug-protein binding studies.
Topics: Nadolol; Nifedipine; Pharmaceutical Preparations; Prazosin; Propanolamines; Protein Binding; Ultrafiltration; Verapamil | 1984 |
Effects of vasodilators on the systemic capacitance vessels, a study with the measurement of the mean circulatory pressure in dogs.
Topics: Animals; Blood Pressure; Blood Vessels; Blood Volume; Cardiac Output; Diltiazem; Dogs; Heart Rate; Isosorbide Dinitrate; Molsidomine; Niacinamide; Nicorandil; Nifedipine; Nitroglycerin; Prazosin; Sydnones; Trapidil; Vascular Resistance; Vasodilator Agents; Venous Pressure; Verapamil | 1984 |
Calcium- and potassium-channel blockers interact with alpha-adrenoceptors.
Topics: Aminopyridines; Animals; Brain; Calcium; Clonidine; Gallopamil; Guanidines; Ion Channels; Myocardium; Potassium; Prazosin; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Tetraethylammonium Compounds; Verapamil | 1980 |
Aldosterone response to antihypertensive treatment.
Topics: Adult; Aged; Aldosterone; Angiotensin II; Antihypertensive Agents; Atenolol; Blood Pressure; Dipeptides; Enalapril; Ethanolamines; Humans; Hypertension; Middle Aged; Prazosin; Pyridazines; Renin; Renin-Angiotensin System; Vasodilator Agents; Verapamil | 1982 |
Use of calcium antagonists as monotherapy in the management of hypertension.
Topics: Calcium; Calcium Channel Blockers; Humans; Hypertension; Nicardipine; Nifedipine; Nitroprusside; Prazosin; Renin; Vasodilation; Verapamil | 1984 |
Combined alpha adrenoceptor antagonism and calcium channel blockade in normal subjects.
Topics: Administration, Oral; Adult; Biological Availability; Blood Pressure; Chromatography, High Pressure Liquid; Drug Evaluation; Drug Synergism; Heart Rate; Humans; Hypotension, Orthostatic; Kinetics; Male; Muscle, Smooth, Vascular; Norepinephrine; Prazosin; Quinazolines; Random Allocation; Verapamil | 1984 |
Differential effects of strychnine on two types of vascular muscle.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Aorta, Thoracic; Cardiovascular Agents; Male; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Prazosin; Rats; Rats, Inbred Strains; Strychnine; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Verapamil | 1984 |
Action of the Na+ ionophore monensin on vascular smooth muscle of guinea-pig aorta.
Topics: Adenosine Triphosphate; Animals; Aorta, Thoracic; Furans; Glucose; Guinea Pigs; Hypoxia; In Vitro Techniques; Male; Monensin; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Ouabain; Phentolamine; Potassium; Prazosin; Sodium; Verapamil | 1984 |
The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Calcium Channel Blockers; Epoprostenol; In Vitro Techniques; Myocardial Contraction; Prazosin; Propranolol; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1995 |
Bursting firing of action potentials in central snail neurons elicited by d-amphetamine: role of the electrogenic sodium pump.
Topics: Action Potentials; Animals; Atropine; Dextroamphetamine; Dose-Response Relationship, Drug; Edetic Acid; Esophagus; Haloperidol; Hexamethonium; Magnesium; Neurons; Ouabain; Patch-Clamp Techniques; Phenobarbital; Potassium; Prazosin; Propranolol; Snails; Sodium; Sodium-Potassium-Exchanging ATPase; Temperature; Tubocurarine; Verapamil | 1995 |
An individualized approach to the hypertensive patient with renal disease: six illustrative case studies.
Topics: Adrenergic alpha-Antagonists; Aged; Angiotensin-Converting Enzyme Inhibitors; Arterial Occlusive Diseases; Auscultation; Benzothiadiazines; Cough; Diabetes Mellitus, Type 1; Diuretics; Drug Therapy, Combination; Female; Furosemide; Humans; Hypertension; Male; Middle Aged; Minoxidil; Prazosin; Proteinuria; Sodium Chloride Symporter Inhibitors; Verapamil | 1995 |
Cocaine and benzoylecgonine constrict cerebral arteries by different mechanisms.
Topics: Animals; Calcium; Cats; Cerebral Arteries; Cocaine; Female; Male; Norepinephrine; Oxidopamine; Prazosin; Ryanodine; Sympathectomy, Chemical; Vasoconstriction; Vasomotor System; Verapamil; Yohimbine | 1995 |
Hypertriglyceridemia in experimental diabetes: relationship to cardiac dysfunction.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Cholesterol; Clofibrate; Diabetes Mellitus, Experimental; Dichloroacetic Acid; Heart; Heart Diseases; Hydralazine; Hypertriglyceridemia; In Vitro Techniques; Insulin; Lipids; Male; Palmitates; Prazosin; Rats; Rats, Wistar; Triglycerides; Verapamil | 1994 |
[Relation of effects of matrine on rat vasa deferens to activation of calcium channels].
Topics: Alkaloids; Animals; Calcium Channel Agonists; Dose-Response Relationship, Drug; In Vitro Techniques; Male; Matrines; Muscle Contraction; Nifedipine; Prazosin; Quinolizines; Rats; Rats, Wistar; Stimulation, Chemical; Vas Deferens; Verapamil | 1994 |
Influence of the formamidine pesticide amitraz and its metabolites on porcine myometrial contractility: involvement of alpha 2-adrenoceptors and Ca2+ channels.
Topics: Amidines; Animals; Calcium; Calcium Channels; Carbachol; Dose-Response Relationship, Drug; Female; Insecticides; Luteal Phase; Myometrium; Prazosin; Receptors, Adrenergic, alpha-2; Swine; Toluidines; Uterine Contraction; Verapamil; Yohimbine | 1994 |
Atrial natriuretic peptide inhibits the purinergic and not the adrenergic component of electrically induced contractile responses in guinea pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic Antagonists; Animals; Atrial Natriuretic Factor; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Naloxone; Neurotransmitter Agents; Nitrendipine; Phenylephrine; Prazosin; Receptors, Adrenergic; Receptors, Purinergic; Vas Deferens; Verapamil; Yohimbine | 1993 |
Role of Na(+)-Ca2+ exchange in the regulation of vascular smooth muscle tension.
Topics: Animals; Caffeine; Calcium; Carrier Proteins; Dose-Response Relationship, Drug; Female; Hydrogen-Ion Concentration; Intracellular Membranes; Isometric Contraction; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nerve Endings; Ouabain; Phentolamine; Prazosin; Rabbits; Sarcolemma; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase; Vascular Resistance; Verapamil | 1993 |
Effects of haloperidol and chlorpromazine on smooth muscle contractility, platelet aggregation and neuronal calcium current.
Topics: Animals; Antipsychotic Agents; Butyrophenones; Calcium Channel Blockers; Calcium Channels; Calmodulin; Chlorpromazine; Droperidol; Electric Stimulation; Guinea Pigs; Haloperidol; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Neurons; Phenothiazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prazosin; Rats; Rats, Wistar; Snails; Sulpiride; Thrombin; Ureter; Verapamil | 1995 |
Influence of adrenergic and cholinergic mediators on the equine jejunum in vitro.
Topics: Acetylcholine; Adrenergic Agonists; Adrenergic Antagonists; Animals; Atropine; Brimonidine Tartrate; Calcium Channel Blockers; Cholinergic Agonists; Cholinergic Antagonists; Dose-Response Relationship, Drug; Horses; Isoproterenol; Jejunum; Muscle Contraction; Muscle, Smooth; Norepinephrine; Oxymetazoline; Parasympathetic Nervous System; Phentolamine; Phenylephrine; Prazosin; Quinoxalines; Sympathetic Nervous System; Tetrodotoxin; Verapamil; Yohimbine | 1996 |
Effects of verapamil on acute murine Chagas' disease.
Topics: Acute Disease; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Cells, Cultured; Chagas Disease; Diltiazem; Endothelium, Vascular; GTP-Binding Proteins; Humans; Male; Mice; Myocardium; Prazosin; Propranolol; Trypanosoma cruzi; Umbilical Veins; Verapamil | 1996 |
Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.
Topics: 3T3 Cells; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Bone Neoplasms; Cell Membrane; Colchicine; Drug Resistance, Multiple; Genetic Vectors; Humans; Mice; Nicardipine; Onium Compounds; Organophosphorus Compounds; Osteosarcoma; Point Mutation; Prazosin; Recombinant Fusion Proteins; Rhodamine 123; Rhodamines; Transfection; Tumor Cells, Cultured; Vaccinia virus; Verapamil; Vinblastine | 1996 |
Hemodynamic profile of activation of histamine H3 receptors by R-alpha-methylhistamine in the guinea pig.
Topics: Animals; Atenolol; Guinea Pigs; Hemodynamics; Hexamethonium; Histamine Agonists; Male; Methylhistamines; Prazosin; Receptors, Histamine H3; Verapamil | 1996 |
Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine.
Topics: Affinity Labels; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Biological Transport, Active; Chloroquine; Drug Interactions; Drug Resistance, Multiple; Fluorescent Dyes; Humans; Kinetics; Mefloquine; Neoplasms; Prazosin; Tumor Cells, Cultured; Verapamil; Vinblastine | 1996 |
Multidrug-resistant human sarcoma cells with a mutant P-glycoprotein, altered phenotype, and resistance to cyclosporins.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Cell Survival; Cyclosporins; Dihydropyridines; DNA Topoisomerases, Type II; Doxorubicin; Drug Resistance, Multiple; Humans; Neoplasm Proteins; Phenotype; Polymerase Chain Reaction; Prazosin; Rhodamine 123; Rhodamines; Sarcoma; Vault Ribonucleoprotein Particles; Verapamil | 1997 |
Effects of 5HT2 receptor antagonists on responses to potassium depolarization in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Cinnarizine; Cyproheptadine; Diltiazem; Drug Synergism; Felodipine; Female; In Vitro Techniques; Ketanserin; Male; Mianserin; Muscle Contraction; Nifedipine; Potassium; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Reproducibility of Results; Ritanserin; Serotonin Antagonists; Verapamil | 1997 |
Drug induced contraction and relaxation in mouse isolated aorta.
Topics: 1-Methyl-3-isobutylxanthine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta; Bethanechol; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Muscarinic Agonists; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Neuromuscular Depolarizing Agents; Nitroprusside; Norepinephrine; Phosphodiesterase Inhibitors; Potassium Chloride; Prazosin; Serotonin; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 1997 |
Drug binding to P-glycoprotein is inhibited in normal tissues following SDZ-PSC 833 treatment.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Brain; Calcium Channel Blockers; Capillaries; Cyclosporine; Cyclosporins; Drug Interactions; Fluorescent Dyes; Injections, Subcutaneous; Iodine Radioisotopes; Kidney; Liver; Male; Microvilli; Photoaffinity Labels; Prazosin; Rats; Rats, Sprague-Dawley; Rhodamine 123; Rhodamines; Verapamil; Vinblastine | 1998 |
Structural flexibility of the linker region of human P-glycoprotein permits ATP hydrolysis and drug transport.
Topics: 3T3 Cells; Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Sequence; Animals; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Base Sequence; Biological Transport; Cell Membrane; Drug Resistance, Multiple; Genetic Vectors; HeLa Cells; Humans; Hydrolysis; Iodine Radioisotopes; Mice; Molecular Sequence Data; Mutagenesis, Insertional; Osteosarcoma; Peptide Fragments; Prazosin; Protein Binding; Protein Conformation; Recombinant Proteins; Sequence Deletion; Tumor Cells, Cultured; Verapamil | 1998 |
Long-term treatment with fluoxetine associates with peripheral effects on rat vas deferens contractility.
Topics: Adrenergic Agents; Animals; Antidepressive Agents, Second-Generation; Binding Sites; Calcium; Cyclooxygenase Inhibitors; Fluoxetine; Indomethacin; Isoproterenol; Ketanserin; Male; Muscle Contraction; Nitroprusside; Norepinephrine; Prazosin; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Vas Deferens; Verapamil | 1999 |
Effects of vasopressin on the sympathetic contraction of rabbit ear artery during cooling.
Topics: Adenosine Triphosphate; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Azepines; Calcium Channel Blockers; Calcium Channels; Cold Temperature; Ear; Electric Stimulation; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Phentolamine; Prazosin; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Rabbits; Receptors, Adrenergic; Sympathetic Nervous System; Vasoconstriction; Vasoconstrictor Agents; Vasopressins; Verapamil; Yohimbine | 1999 |
A single amino acid residue contributes to distinct mechanisms of inhibition of the human multidrug transporter by stereoisomers of the dopamine receptor antagonist flupentixol.
Topics: Adenosine Triphosphate; Alanine; Amino Acid Substitution; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Transport; Dopamine Antagonists; Flupenthixol; HeLa Cells; Humans; Hydrolysis; Iodine Radioisotopes; Mutagenesis, Site-Directed; Phenylalanine; Photoaffinity Labels; Prazosin; Receptors, Dopamine; Stereoisomerism; Substrate Specificity; Tumor Cells, Cultured; Verapamil | 1999 |
Both ATP sites of human P-glycoprotein are essential but not symmetric.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amino Acid Motifs; Amino Acid Substitution; Antibodies, Monoclonal; Asparagine; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding Sites; Biological Transport; Body Temperature; Cell Membrane; Consensus Sequence; Enzyme Activation; Freezing; HeLa Cells; Humans; Peptide Fragments; Phosphorus Radioisotopes; Photoaffinity Labels; Point Mutation; Prazosin; Protein Conformation; Recombinant Fusion Proteins; Vanadates; Verapamil | 1999 |
Regulation of renal artery smooth muscle tone by alpha1-adrenoceptors: role of voltage-gated calcium channels and intracellular calcium stores.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Membrane; Diltiazem; Dioxanes; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Ischemia; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Phenoxybenzamine; Phenylephrine; Piperazines; Prazosin; Receptors, Adrenergic, alpha-1; Renal Artery; Renal Circulation; Swine; Thapsigargin; Verapamil | 2000 |
Differential effects of drugs interacting with autonomic transmitters on responses of rat vas deferens to field stimulation.
Topics: Adrenergic alpha-Antagonists; Animals; Calcium Channel Blockers; Drug Interactions; Electric Stimulation; Male; Muscle Contraction; Neurotransmitter Agents; Nifedipine; Prazosin; Rats; Rats, Wistar; Suramin; Vas Deferens; Vasodilator Agents; Verapamil | 2000 |
Mechanisms of the increased pressor response to vasopressors in the mesenteric bed of nitric oxide-deficient hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesentery; Methoxamine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Chloride; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation; Verapamil | 2001 |
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Boron Compounds; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Drug Resistance, Multiple; Female; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Humans; Intracellular Membranes; Kinetics; Microsomes; Mitoxantrone; Neoplasm Proteins; Polymerase Chain Reaction; Prazosin; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Verapamil | 2001 |
Transmembrane domain (TM) 9 represents a novel site in P-glycoprotein that affects drug resistance and cooperates with TM6 to mediate [125I]iodoarylazidoprazosin labeling.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Binding, Competitive; Cells, Cultured; Cricetinae; Cyclosporine; Drug Interactions; Drug Resistance; Drug Resistance, Multiple; Iodine Radioisotopes; Membrane Proteins; Mutagenesis, Site-Directed; Prazosin; Protein Structure, Tertiary; Transfection; Verapamil | 2001 |
Further characterization of the sixth transmembrane domain of Pgp1 by site-directed mutagenesis.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cell Line; Cricetinae; Hydrophobic and Hydrophilic Interactions; Membrane Proteins; Mutagenesis, Site-Directed; Photoaffinity Labels; Prazosin; Structure-Activity Relationship; Transfection; Verapamil | 2001 |
Multidrug transporter activity in lymphocytes.
Topics: Adrenergic alpha-Antagonists; Aniline Compounds; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; B-Lymphocytes; Calcium Channel Blockers; Fluoresceins; Fluorescent Dyes; Lymphocytes; Mice; Mice, Knockout; Mitoxantrone; Multidrug Resistance-Associated Proteins; Paclitaxel; Prazosin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Verapamil; Xanthenes | 2004 |
Gomisin A alters substrate interaction and reverses P-glycoprotein-mediated multidrug resistance in HepG2-DR cells.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Anticarcinogenic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Blotting, Western; Cell Line, Tumor; Cell Survival; Cyclooctanes; Dioxoles; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Hydrolysis; Lignans; Prazosin; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Vanadates; Verapamil; Vinblastine | 2006 |
Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dimerization; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Molecular Structure; Paclitaxel; Prazosin; Quinine; Rhodamine 123; Verapamil | 2009 |
Substrate- and species-dependent inhibition of P-glycoprotein-mediated transport: implications for predicting in vivo drug interactions.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Boron Compounds; Drug Evaluation, Preclinical; Drug Interactions; Flow Cytometry; Fluorescent Dyes; Humans; Pharmaceutical Preparations; Prazosin; Rats; Species Specificity; Substrate Specificity; Swine; Verapamil | 2011 |
β2-adrenergic receptors mediate cardioprotection through crosstalk with mitochondrial cell death pathways.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Cardiomyopathies; Cyclosporine; Doxorubicin; Enzyme Inhibitors; Male; Mice; Mice, Knockout; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocytes, Cardiac; Oxidative Stress; Prazosin; Proto-Oncogene Proteins c-akt; Receptors, Adrenergic, beta-2; Signal Transduction; Survival Rate; Verapamil | 2011 |
Breast cancer resistance protein BCRP (ABCG2)-mediated transepithelial nitrofurantoin secretion and its regulation in human intestinal epithelial (Caco-2) layers.
Topics: Adenosine; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Diet; Diketopiperazines; Dogs; Drug Interactions; Gene Expression Regulation; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Mucosa; Mice; Neoplasm Proteins; Nitrofurantoin; Prazosin; Verapamil | 2011 |
Prejunctional facilitatory effect of a thiol-alkylating agent N-Ethylmaleimide on neurogenic contractions in rat prostate smooth muscle.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Atropine; Calcium Channel Blockers; Electric Stimulation; Enzyme Inhibitors; Ethylmaleimide; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Nitroarginine; Prazosin; Prostate; Rats; Rats, Wistar; Suramin; Verapamil | 2012 |
Characterization of a multiple endogenously expressed adenosine triphosphate-binding cassette transporters using nuclear and cellular membrane affinity chromatography columns.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Cell Membrane; Chromatography, Affinity; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Estrone; Etoposide; Glioblastoma; Humans; Ligands; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Nuclear Envelope; Prazosin; Protein Binding; Verapamil | 2014 |
Shear stress-induced angiogenesis in mouse muscle is independent of the vasodilator mechanism and quickly reversible.
Topics: Angiogenesis Inducing Agents; Animals; Blood Pressure; Cromakalim; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Ethanol; Heart Rate; Indomethacin; Male; Mice; Muscle, Skeletal; Neovascularization, Physiologic; Nitric Oxide Synthase; Prazosin; Stress, Mechanical; Vasodilator Agents; Verapamil | 2016 |
Evidence for the Interaction of A
Topics: Adenosine A3 Receptor Agonists; ATP Binding Cassette Transporter, Subfamily B; Azides; Binding Sites; HeLa Cells; Humans; Models, Molecular; Molecular Docking Simulation; Paclitaxel; Prazosin; Structure-Activity Relationship; Verapamil | 2019 |