verapamil has been researched along with piperidines in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (26.77) | 18.7374 |
| 1990's | 51 (40.16) | 18.2507 |
| 2000's | 20 (15.75) | 29.6817 |
| 2010's | 19 (14.96) | 24.3611 |
| 2020's | 3 (2.36) | 2.80 |
| Authors | Studies |
|---|---|
| de Brito, FS; Pereira, MH | 1 |
| Candau, LA; de Patta, M; Padilha, JC; Scherr, C; Tasca, R; Weiskopf, JS | 1 |
| Anstett, M; Atassi, G; Bizzari, JP; Genton, A; Léonce, S; Pérez, V; Pierré, A | 1 |
| Berga, P; Bou, J; Cardelús, I; Gristwood, RW; Llenas, J | 1 |
| Berga, P; Furman, BL; Gristwood, RW; Jauregui, J; Llenas, J | 1 |
| Borgers, M; Thoné, F; Vandeplassche, G | 1 |
| Allen, AD; Barrett, RJ; Taylor, DR; Wright, KF | 1 |
| Appell, KC; Barrett, RJ; Kilpatrick, BF; Nolan, JC; Proakis, AG; Walsh, DA | 1 |
| Crosland, RD | 1 |
| Hahn, EW; Osswald, H; Pommerenke, EW; Volm, M | 1 |
| Peters, T; Scheufler, E | 1 |
| Borgers, M; De Clerck, F; Vandewiele, R; Ver Donck, L; Verellen, G | 1 |
| Keefe, DL; Miura, D; Somberg, JC | 1 |
| Ochillo, RF; Tsai, CS | 1 |
| Garcia, L; Lazdunski, M; Rieger, F; Romey, G | 1 |
| Diener, M; Knobloch, SF; Rummel, W | 1 |
| Ishikawa, T; Murakami, H; Watanabe, H | 1 |
| Somberg, J | 1 |
| Barhanin, J; Henning, R; Lazdunski, M; Lerch, U; Oekonomopulos, R; Qar, J; Romey, G; Urbach, H | 1 |
| Morganroth, J; Nestico, PF | 1 |
| Huang, SK; Marcus, FI | 1 |
| Affolter, H; Burkard, WP; Pletscher, A | 1 |
| Olesen, SP | 1 |
| Koch, P; Nebel, U; Peters, T; Wermelskirchen, D; Wilffert, B; Wilhelm, D | 1 |
| Culver, PJ; Rattan, S | 1 |
| Dormehl, IC; du Plessis, M; Maree, M; Meyer, BJ; Pilloy, W | 1 |
| Aronow, WS | 1 |
| Dose, M | 1 |
| Opie, LH | 1 |
| Hisayama, T; Suzuki, S; Takayanagi, I | 1 |
| Hillis, WS; Whiting, B | 1 |
| Ohashi, M; Takayanagi, I | 1 |
| Somberg, JC | 1 |
| Duff, HJ; Oates, JA; Roden, DM; Woosley, RL | 1 |
| Ikeda, N; Josephson, MA; Kannan, R; Nademanee, K; Singh, BN; Venkatesh, N | 1 |
| Albuquerque, EX; Daly, JW; Kauffman, FC; Tamburini, R | 1 |
| Ronfeld, RA | 1 |
| Jewitt, DE | 1 |
| Oguro, K; Ono, H | 1 |
| Harrison, DC; Kates, RE; Keefe, DL | 1 |
| Hashimoto, K; Ohara, N; Ono, H | 1 |
| Antman, EM; Braunwald, E; Muller, JE; Stone, PH | 1 |
| Bergey, JL; McCallum, JD; Nocella, K | 1 |
| Hashimoto, K; O'Hara, N; Ono, H | 1 |
| De Clerck, F; Lu, HR; Remeysen, P | 2 |
| Berlion, M; Dieterlen, A; Lucas, C; Marchal, S; Merlin, JL; Poullain, MG; Ramacci, C; Schultz, G | 1 |
| Park, SR; Ryu, GH; Suh, CK | 1 |
| De Clerck, F; Lu, HR | 1 |
| Bennis, S; Robert, J | 1 |
| Lucas, C; Marchal, S; Merlin, JL; Paraire, M; Poullain, MG; Ramacci, C | 1 |
| Gibassier, J; Leclech, G; Lucas, C; Massart, C; Pourquier, P; Raoul, M; Robert, J | 1 |
| Berlion, M; Bizzari, JP; Calvo, F; Haddad, P; Lucas, C; Soudon, J | 1 |
| Berlion, M; Bizzari, JP; Desplaces, A; Dufer, J; Joly, P; Millot-Broglio, C; Oum'Hamed, Z | 1 |
| Guerci, A; Guerci, O; Humbert, JC; Marchal, S; Merlin, JL; Missoum, N; Ramacci, C; Tsuruo, T | 1 |
| Berlion, M; Kernaleguen, D; Le Bot, MA; Riché, C; Robert, J | 1 |
| Stolc, S | 1 |
| de Vries, EG; Hill, BT; Hosking, LK; Mulder, NH; van der Graaf, WT; Whelan, RD | 1 |
| Anstett, M; Atassi, G; Léonce, S; Pérez, V; Pierré, A; Prost, JF | 1 |
| Berlion, M; Bizzari, JP; Canal, P; Julia, AM; Lucas, C; Milano, G; Robert, J; Roché, H | 1 |
| Bryce, DK; Desai, MC; Heym, J; Longo, KP; McLean, S; Rosen, T; Schmidt, AW; Snider, RM | 1 |
| Hill, BT; Hosking, LK | 1 |
| Hayashi, Y; Kamibayashi, T; Kawabata, K; Sumikawa, K; Takada, K; Yamatodani, A; Yoshiya, I | 1 |
| Berger, W; Friedrich, K; Garcia, ML; Glossmann, H; Goetz, MA; Hering, S; Kaczorowski, GJ; Liesch, JM; Savchenko, A; Zink, DL | 1 |
| Guttmann, I; Mozes, A; Scheufler, E; Wilffert, B | 1 |
| Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Kofod, H | 1 |
| Berlion, M; Kernaleguen, D; Le Bot, MA; Riché, C; Simon, I | 1 |
| Chapey, C; Hu, YP; Robert, J | 1 |
| Ford, PJ; Germann, UA; Harding, MW; Mason, VS; Shlyakhter, D | 1 |
| Glossmann, H; Hanner, M; Moebius, FF; Reiter, RJ | 1 |
| Atassi, G; Dubois, J; Hanocq, M; Tassin, JP | 1 |
| Belhoussine, R; Manfait, M; Morjani, H | 1 |
| Aleksanian, AR; Arutiunian, NS; Galoian, AA; Gerasimian, DA | 1 |
| Cayre, A; Finat-Duclos, F; Maublant, J; Moins, N; Verrelle, P | 2 |
| Bandera, R; Bartke, A; Debeljuk, L | 1 |
| Belhoussine, R; Lahlil, R; Manfait, M; Morjani, H | 1 |
| Bril, A; Cheval, B; Faivre, JF; Forest, MC | 1 |
| Buée-Scherrer, V; Cecchelli, R; Dehouck, MP; Descamps, L; Duhem, C; Fenart, L; Poullain, MG | 1 |
| Belhoussine, R; Manfait, M; Millot, JM; Morjani, H; Sharonov, S | 1 |
| Chiba, S; Furukawa, Y; Hoyano, Y; Kasama, M; Oguchi, T | 1 |
| Dai, DZ; De Clerck, F; Lu, HR; Remeysen, P; Saels, A; Yang, P | 1 |
| Kubota, I; Tachibana, H; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S | 1 |
| Chiba, S; Furukawa, Y; Hirose, M; Kurogouchi, F; Miyashita, Y; Nakajima, K | 1 |
| Artursson, P; Hidalgo, IJ; Raeissi, SD; Segura-Aguilar, J | 1 |
| Diéguez, G; Fernández, N; García-Villalón, AL; Gómez, B; Martínez, MA; Monge, L; Sánchez, MA | 1 |
| Dohmoto, H; Hashimoto, K; Sugiyama, A; Takahara, A; Yoshimoto, R | 2 |
| Kubota, I; Miyashita, T; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S | 1 |
| Bible, KC; Boerner, SA; Kaufmann, SH; Tourne, ME | 1 |
| Bittinger, F; Brockerhoff, P; Deutsch, C; Kilbinger, H; Kirkpatrick, CJ; Roth, E; Wessler, I | 1 |
| Dai, DZ; Kong, RZ; Li, HT; Wang, YQ | 1 |
| Bauer, EP; LeDoux, JE; Schafe, GE | 1 |
| Avery, MJ; DePasquale, MJ; Fossa, AA; Leishman, DJ; Raunig, DL | 1 |
| Jankovic, SM; Jankovic, SV; Protic, BA | 1 |
| Awe, SO; Harris, LC; Kulkarni, K; LeDay, AM; Ohia, SE; Opere, CA; Sharif, NA | 1 |
| Avery, M; Fermini, B; Fossa, AA; Raunig, DL; Wang, E; Wisialowski, T; Wolfgang, E | 1 |
| Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N | 1 |
| Aiba, T; Ding, WG; Horie, M; Inagaki, M; Matsuura, H; Miyoshi, S; Noda, T; Shimizu, W; Sunagawa, K; Toyoda, F; Zankov, DP | 1 |
| Mitchell, AM; Mortimer, RH; Tom, M | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 1 |
| Bíró, T; Bugovics, G; Maksay, G | 1 |
| Fukuda, H; Kamikozawa, Y; Ohashi, R; Sugiura, M; Tamai, I; Yabuuchi, H | 1 |
| Hayashi, Y; Ito, I; Iwasaki, M; Kamibayashi, T; Kawai, Y; Mashimo, T; Takada, K; Yamatodani, A | 1 |
| Hendrikse, NH; Ishiwata, K; Kawamura, K; Yanai, K | 1 |
| Boldt, A; Gergs, U; Neumann, J; Pönicke, K; Silber, RE; Simm, A | 1 |
| Kida, S; Kim, R; Moki, R | 1 |
| Gao, WY; Hu, J; Huang, LQ; Liu, CX; Ma, L; Man, SL | 1 |
| Fujii, M; Imaizumi, Y; Ohya, S; Yamamura, H | 1 |
| Fossa, AA; Jeyaraj, D; Rosenbaum, DS; Said, TH; Wilson, LD | 1 |
| Ambudkar, SV; Bhatnagar, J; Chen, JJ; Chen, WM; Chen, ZS; Lan, P; Ruan, ZX; Shu, C; Sodani, K; Wang, J; Xiao, ZJ; Ye, WC; Zhang, DM | 1 |
| Cao, Y; Jusko, WJ | 1 |
| Chen, WM; Chen, ZS; Fu, LW; Fung, KP; Lan, P; Li, YJ; Peng, YH; Ruan, ZX; Shu, C; Wang, J; Yao, Z; Ye, WC; Yiu, A; Zhang, DM | 1 |
| Cai, L; Li, L; Liu, J; Peng, W; Yang, J; Yang, S; Zhang, Q | 1 |
| Ando, T; Furukawa, T; Hayakawa, T; Kanda, Y; Kobayashi, S; Kunihiro, T; Kurokawa, J; Matsui, E; Yada, H | 1 |
| Aikawa, N; Suzuki, Y; Takaba, K | 1 |
| Grewal, RK; Kalsi, H | 1 |
| Bilbault, P; Gourieux, B; Lambert Kuhn, E; Levêque, D; Lioure, B | 1 |
| Ando, K; Cao, X; Izumi-Nakaseko, H; Matsukura, S; Nakamura, Y; Sugiyama, A; Wada, T; Yamazaki, H | 1 |
| Jimbo, Y; Nakasono, S; Saito, A; Takahashi, M | 1 |
| Delorme, V; Jang, J; Jeong, J; Kim, G; Kim, R; Park, DE; Woo, M | 1 |
| Gouws, C; Hamman, J; Haynes, RK; Heyns, J; Willers, C; Wong, HN | 1 |
| Christoffels, A; Cloete, R; Joubert, J; Kapp, E; Malan, SF | 1 |
| Chen, WM; Hou, W; Huang, ZX; Lin, J; Liu, J; Meng, Y; Wang, ZY; Xu, XF | 1 |
| Ito, S; Iwamoto, K; Kamimura, H; Mizunaga, M; Nakayama, K; Negoro, T; Nishiwaki, M; Nomura, Y; Suemizu, H; Yamazaki, H; Yoneda, N | 1 |
| Bix, GJ; Fraser, JF; Gorman, A; Maniskas, ME; Roberts, JM | 1 |
| Faraji, N; Hasanein, P; Karimi, SA; Komaki, A; Komaki, H; Noorbakhsh, M; Reza Nikoo, M; Shahidi, S | 1 |
11 review(s) available for verapamil and piperidines
| Article | Year |
|---|---|
The treatment of ventricular rhythm disturbances.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Disopyramide; Electric Countershock; Electric Stimulation; Electrocardiography; Exercise Test; Flecainide; Heart Ventricles; Humans; Lidocaine; Phenytoin; Piperidines; Procainamide; Quinidine; Risk; Tachycardia; Tocainide; United States; Ventricular Fibrillation; Verapamil | 1986 |
Antiarrhythmic drug therapy. Recent advances and current status.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Disopyramide; Drug Administration Schedule; Encainide; Flecainide; Heart Conduction System; Humans; Imidazoles; Lidocaine; Mexiletine; Moricizine; Myocardial Contraction; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tocainide; Verapamil | 1985 |
Cardiac arrhythmias in the elderly: antiarrhythmic drug treatment.
Topics: Aged; Amiodarone; Anilides; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Compounds; Digoxin; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Piperidines; Procainamide; Propranolol; Quinidine; Tocainide; Verapamil | 1986 |
Antiarrhythmic drug therapy of ventricular arrhythmias.
Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bretylium Tosylate; Disopyramide; Flecainide; Heart Ventricles; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Phenytoin; Piperidines; Procainamide; Propafenone; Propiophenones; Quinidine; Sotalol; Tocainide; Verapamil | 1986 |
Medical treatment of angina pectoris. 8. Miscellaneous antianginal drugs.
Topics: Angina Pectoris; Digitalis Glycosides; Dipyridamole; Ethanol; Humans; Isoquinolines; Papaverine; Piperidines; Placebos; Prenylamine; Smoking; Verapamil | 1973 |
The electrophysiology and pharmacology of verapamil, flecainide, and amiodarone: correlations with clinical effects and antiarrhythmic actions.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzofurans; Drug Interactions; Flecainide; Heart; Hemodynamics; Humans; In Vitro Techniques; Myocardial Contraction; Piperidines; Verapamil | 1984 |
Comparative pharmacokinetics of new antiarrhythmic drugs.
Topics: Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Humans; Kinetics; Mexiletine; Piperidines; Tocainide; Verapamil | 1980 |
Hemodynamic effects of newer antiarrhythmic drugs.
Topics: Acebutolol; Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Atenolol; Benzeneacetamides; Disopyramide; Dogs; Hemodynamics; Humans; Mexiletine; Piperidines; Tocainide; Verapamil | 1980 |
New antiarrhythmic drugs: their place in therapy.
Topics: Action Potentials; Ajmaline; Amiodarone; Anilides; Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Tosylate; Disopyramide; Encainide; Hemodynamics; Humans; Kinetics; Moricizine; Morpholines; Phenothiazines; Piperidines; Verapamil | 1981 |
Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications.
Topics: Benzazepines; Calcium Channel Blockers; Cardiovascular Diseases; Coronary Circulation; Diltiazem; Hemodynamics; Humans; Myocardial Contraction; Nifedipine; Nitrogen; Perhexiline; Piperidines; Pyridines; Regional Blood Flow; Vasodilation; Verapamil | 1980 |
[Effect of quinine on the multiple drug resistance and intracellular distribution of pirarubicin in LR73 tumor cells: a comparative study with verapamil and S9788 by confocal laser microspectrofluorometry].
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cricetinae; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; In Vitro Techniques; Microscopy, Confocal; Piperidines; Quinine; Spectrometry, Fluorescence; Triazines; Tumor Cells, Cultured; Verapamil | 1997 |
3 trial(s) available for verapamil and piperidines
| Article | Year |
|---|---|
[Verapamil in the treatment of angina pectoris. Double-blind study with clinical and ergometric evaluation].
Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Perhexiline; Piperidines; Placebos; Verapamil | 1979 |
Selection of an antiarrhythmic drug for a sudden-death-prevention trial.
Topics: Acecainide; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Benzeneacetamides; Bretylium Compounds; Clinical Trials as Topic; Death, Sudden; Encainide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Moricizine; Morpholines; Phenothiazines; Piperidines; Tocainide; Verapamil | 1982 |
In vitro activity of S 9788 on a multidrug-resistant leukemic cell line and on normal hematopoietic cells-reversal of multidrug resistance by sera from phase I-treated patients.
Topics: Antineoplastic Agents; Bone Marrow Cells; Cell Division; Cell Line; Cell Survival; Culture Media; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Hematopoietic Stem Cells; Humans; Leukemia, T-Cell; Neoplasms; Phenotype; Piperidines; Reference Values; Triazines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1995 |
113 other study(ies) available for verapamil and piperidines
| Article | Year |
|---|---|
[Comparative study of the medium term use of verapamil and perhexiline in the treatment of chronic coronary insufficiency. Clinical and cycloergometric evaluation].
Topics: Adult; Aged; Chronic Disease; Coronary Disease; Electrocardiography; Exercise Test; Female; Humans; Male; Middle Aged; Perhexiline; Piperidines; Placebos; Verapamil | 1978 |
Effects of a new triazinoaminopiperidine derivative on adriamycin accumulation and retention in cells displaying P-glycoprotein-mediated multidrug resistance.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Carcinoma, Squamous Cell; Cell Cycle; Cell Membrane; Cells, Cultured; Colonic Neoplasms; Cricetinae; Cricetulus; Dihydropyridines; Doxorubicin; Drug Resistance; Flow Cytometry; Fluorescence; Humans; Kinetics; Leukemia P388; Leukemia, Myeloid, Acute; Lung; Membrane Glycoproteins; Mice; Piperidines; Sensitivity and Specificity; Triazines; Tritium; Tumor Cells, Cultured; Verapamil | 1992 |
Cardiovascular effects of LAS 30538, a new vascular selective Ca(2+)-channel blocker.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Diltiazem; Electrophysiology; Flunarizine; Guinea Pigs; Heart; In Vitro Techniques; Male; Muscle, Smooth, Vascular; Papillary Muscles; Perfusion; Piperidines; Rabbits; Rats; Rats, Inbred SHR; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 1992 |
The calcium channel blocker LAS 30538, unlike nifedipine, verapamil, diltiazem or flunarizine, potently inhibits insulin secretion in-vivo in rats and dogs.
Topics: Administration, Oral; Animals; Blood Glucose; Calcium Channel Blockers; Diltiazem; Dogs; Female; Flunarizine; Glucose Tolerance Test; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Nifedipine; Piperidines; Rats; Rats, Sprague-Dawley; Verapamil | 1992 |
Protective effects of R 56 865 against ischemic damage in the isolated rabbit heart.
Topics: Animals; Benzothiazoles; Calcium; Calcium Channels; Cell Death; Coronary Disease; Female; Hemodynamics; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperidines; Rabbits; Subcellular Fractions; Thiazoles; Verapamil | 1991 |
Cardiovascular and renal actions of AHR-16303B, an antagonist of 5-HT2 receptors and calcium channels, in hypertensive and normotensive rats.
Topics: Administration, Oral; Animals; Blood Pressure; Calcium Channel Blockers; Cardiovascular System; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Injections, Intravenous; Kidney; Male; Piperidines; Propiophenones; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Ritanserin; Serotonin Antagonists; Verapamil | 1991 |
AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels.
Topics: Animals; Atrial Function; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Diuresis; Dose-Response Relationship, Drug; Edema; Guinea Pigs; Heart Atria; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nimodipine; Piperidines; Platelet Aggregation; Propiophenones; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Histamine H1; Receptors, Serotonin; Reflex; Serotonin; Serotonin Antagonists; Tritium; Verapamil | 1991 |
Effect of drugs on the lethality in mice of the venoms and neurotoxins from sundry snakes.
Topics: Animals; Dexamethasone; Diltiazem; Female; Lethal Dose 50; Mice; Mice, Inbred ICR; Neuromuscular Depolarizing Agents; Neurotoxins; Nicergoline; Nifedipine; Piperidines; Piracetam; Primaquine; Reserpine; Snake Venoms; Snakes; Verapamil | 1991 |
Activity of various amphiphilic agents in reversing multidrug resistance of L 1210 cells.
Topics: Animals; Drug Resistance; Ethylamines; Hycanthone; Leukemia L1210; Phenotype; Piperidines; Quinidine; Quinine; Tamoxifen; Trifluoperazine; Verapamil | 1990 |
Phosphatidylserine monolayers as models for drug uptake into membranes and tissue.
Topics: Animals; Aorta; Benzothiazoles; Cell Membrane; Diltiazem; Erythrocyte Membrane; Flunarizine; Heart Atria; Humans; Lidocaine; Membranes, Artificial; Models, Biological; Nitrendipine; Pharmaceutical Preparations; Pharmacokinetics; Phosphatidylserines; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
Class IV Ca2+ antagonists do not affect lipid peroxidation in singlet oxygen challenged cardiomyocytes.
Topics: Animals; Benzothiazoles; Calcium Channel Blockers; Cell Separation; Cinnarizine; Diltiazem; Flunarizine; Lidoflazine; Lipid Peroxidation; Malondialdehyde; Myocardium; Nicardipine; Oxygen; Piperidines; Rats; Thiazoles; Verapamil | 1990 |
Low temperature and muscarinic receptor activities.
Topics: Acetylcholine; Animals; Benzilates; Calcium; Calcium Channel Blockers; Cold Temperature; Gallic Acid; Guinea Pigs; Hypothermia, Induced; Ileum; Kinetics; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Piperidines; Receptors, Muscarinic; Verapamil | 1989 |
Targets for calcium channel blockers in mammalian skeletal muscle and their respective functions in excitation-contraction coupling.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dihydropyridines; Evoked Potentials; Isradipine; Mice; Muscle Contraction; Oxadiazoles; Piperidines; Thiazines; Verapamil | 1988 |
Action of loperamide on neuronally mediated and Ca2+- or cAMP-mediated secretion in rat colon.
Topics: Animals; Calcium; Carbachol; Colforsin; Colon; Cyclic AMP; Electric Stimulation; In Vitro Techniques; Intestinal Mucosa; Loperamide; Male; Morphine; Neurons; Piperidines; Rats; Rats, Inbred Strains; Trifluoperazine; Verapamil | 1988 |
Effects of Ca-antagonists and antispasmodic drugs on contraction by ACh in molluscan smooth muscle.
Topics: Acetylcholine; Animals; Bivalvia; Calcium Channel Blockers; Diltiazem; Dimethylphenylpiperazinium Iodide; Drug Interactions; Gallopamil; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Papaverine; Parasympatholytics; Piperidines; Verapamil | 1985 |
A novel high affinity class of Ca2+ channel blockers.
Topics: Animals; Bepridil; Binding Sites; Calcium Channel Blockers; Cell Line; Dihydropyridines; Fluspirilene; Isradipine; Kinetics; Muscles; Oxadiazoles; Piperidines; Pyrrolidines; Rabbits; Rats; Structure-Activity Relationship; Thiazines; Verapamil | 1988 |
Verapamil, an antagonist at 5-hydroxytryptamine receptors of human blood platelets.
Topics: Adenosine Diphosphate; Binding, Competitive; Blood Platelets; Cerebral Cortex; Gallopamil; Humans; In Vitro Techniques; Ketanserin; Membranes; Piperidines; Receptors, Serotonin; Spiperone; Verapamil | 1985 |
A calcium-dependent reversible permeability increase in microvessels in frog brain, induced by serotonin.
Topics: Animals; Blood-Brain Barrier; Brain; Calcium; Capillary Permeability; Dose-Response Relationship, Drug; Electric Conductivity; Endothelium; Ketanserin; Piperidines; Rana temporaria; Serotonin; Serotonin Antagonists; Verapamil | 1985 |
Different effects of R 56865 and calcium entry blockers on K+- and noradrenaline-induced contractions and 45Ca uptake in rat aorta.
Topics: Animals; Aorta; Benzothiazoles; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Flunarizine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Norepinephrine; Piperidines; Potassium; Rats; Rats, Inbred Strains; Thiazoles; Verapamil | 1988 |
Influence of loperamide on the internal anal sphincter in the opossum.
Topics: Anal Canal; Animals; Drug Interactions; Electric Stimulation; Female; Isoproterenol; Loperamide; Male; Naloxone; Nicotine; Opossums; Piperidines; Pressure; Rectum; Spinal Nerve Roots; Verapamil | 1987 |
The detection and evaluation of drug-induced changes in the gastrointestinal motility of beagle dogs using a 111In-labelled resin mixed into a standard meal as tracer.
Topics: Animal Feed; Animals; Cisapride; Dogs; Gastric Emptying; Gastrointestinal Motility; Indium; Male; Methods; Microspheres; Piperidines; Polystyrenes; Radioisotopes; Time Factors; Verapamil | 1985 |
[Calcium antagonist properties of valperinol].
Topics: Animals; Brachyura; Calcium Channel Blockers; Evoked Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Membrane Potentials; Motor Endplate; Neurons; Piperidines; Receptors, Neurotransmitter; Verapamil | 1984 |
Drugs and the heart. III. Calcium antagonists.
Topics: Angina Pectoris; Aniline Compounds; Arrhythmias, Cardiac; Calcium; Cardiomegaly; Diuretics; Heart Diseases; Heart Failure; Humans; Hypertension; Indapamide; Nifedipine; Perhexiline; Piperidines; Pyridines; Verapamil | 1980 |
Effects of nonspecific smooth muscle relaxants and Ca-blocker on Ca-release and Ca-binding in microsomal fractions from rabbit taenia coli.
Topics: Animals; Calcium; Colon; Gallopamil; In Vitro Techniques; Male; Microsomes; Papaverine; Parasympatholytics; Piperidines; Rabbits; Verapamil | 1980 |
Antiarrhythmic drugs.
Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Disopyramide; Flecainide; Humans; Kinetics; Lidocaine; Mexiletine; Piperidines; Procainamide; Quinidine; Tocainide; Verapamil | 1983 |
The actions of D 600, aspaminol and papaverine on calcium-, potassium- and histamine-induced contractions of isolated rabbit basilar artery, aorta, taenia coli and tracheal smooth muscle.
Topics: Animals; Calcium; Dose-Response Relationship, Drug; Gallopamil; Histamine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Papaverine; Piperidines; Potassium; Rabbits; Verapamil | 1983 |
New directions in antiarrhythmic drug therapy.
Topics: Adrenergic beta-Antagonists; Ajmaline; Amiodarone; Anilides; Anti-Arrhythmia Agents; Aprindine; Benzeneacetamides; Bepridil; Bethanidine; Bretylium Tosylate; Death, Sudden; Disopyramide; Encainide; Flecainide; Humans; Lidocaine; Mexiletine; Moricizine; Phenothiazines; Piperidines; Procainamide; Propafenone; Propiophenones; Pyrrolidines; Quinidine; Tachycardia; Tocainide; Verapamil | 1984 |
Inhibition of calcium-dependent ATPase from sarcoplasmic reticulum by a new class of indolizidine alkaloids, pumiliotoxins A, B, and 251D.
Topics: Alkaloids; Amphibian Venoms; Animals; Caffeine; Calcium-Transporting ATPases; Indolizines; Kinetics; Muscles; Piperidines; Rana pipiens; Rats; Sarcoplasmic Reticulum; Structure-Activity Relationship; Verapamil | 1981 |
Effects of perhexiline on contractile response of rabbit aorta to norepinephrine and potassium.
Topics: Animals; Aorta, Thoracic; Drug Interactions; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Norepinephrine; Perhexiline; Piperidines; Potassium; Rabbits; Verapamil | 1980 |
Effect of an antianginal drug, perhexiline, on myocardial oxygen consumption in anesthetized open-chest dogs compared with verapamil and glyceryl trinitrate.
Topics: Animals; Blood Pressure; Cardiac Surgical Procedures; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Heart Rate; Heart Ventricles; Myocardium; Nitroglycerin; Oxygen Consumption; Perhexiline; Piperidines; Verapamil | 1982 |
Antiarrhythmic evaluation of verapamil, nifedipine, perhexiline and skf 525-A in four canine models of cardiac arrhythmias.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Calcium; Dogs; Female; Heart Rate; Lidocaine; Male; Myocardial Contraction; Nifedipine; Perhexiline; Piperidines; Proadifen; Pyridines; Verapamil | 1981 |
Effects of perhexiline on hemodynamics in anesthetized open-chest dogs.
Topics: Anesthesia; Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Cardiac Output; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Male; Norepinephrine; Perhexiline; Phentolamine; Piperidines; Propranolol; Verapamil | 1981 |
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disease Models, Animal; Electric Stimulation; Electrocardiography; Encainide; Ethanolamines; Guinea Pigs; Heart; Heart Conduction System; Injections, Intravenous; Male; Metoprolol; Nebivolol; Phenethylamines; Piperidines; Sotalol; Sulfonamides; Ventricular Fibrillation; Verapamil | 1995 |
Influence of S9788, a new modulator of multidrug resistance, on the cellular accumulation and subcellular distribution of daunorubicin in P-glycoprotein-expressing MCF7 human breast adenocarcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Nucleus; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Female; Flow Cytometry; Humans; Neoplasm Proteins; Piperidines; Subcellular Fractions; Triazines; Tumor Cells, Cultured; Verapamil | 1995 |
Cardioprotective drugs decrease the Na+ background current.
Topics: Amiloride; Animals; Benzothiazoles; Guinea Pigs; Heart; Heart Arrest, Induced; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil | 1995 |
R 56 865, a Na+/Ca(2+)-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo.
Topics: Aconitine; Animals; Anti-Arrhythmia Agents; Benzothiazoles; Calcium; Dose-Response Relationship, Drug; Hemodynamics; Lidocaine; Male; Piperidines; Random Allocation; Rats; Rats, Wistar; Sodium; Sodium Channels; Tetrodotoxin; Thiazoles; Verapamil | 1993 |
[Difference between the effects of S9788, verapamil and quinine on the reversion of multidrug resistance in two human tumor cell lines].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Death; Doxorubicin; Drug Resistance, Multiple; Humans; Leukemia, Erythroblastic, Acute; Piperidines; Quinine; Triazines; Tumor Cells, Cultured; Verapamil | 1994 |
[Effect of the modality of exposure on the action of S9788 on the modulation of multidrug resistance of human tumor cell lines].
Topics: Adenocarcinoma; Antineoplastic Agents; Breast Neoplasms; Cyclosporine; Daunorubicin; Drug Resistance, Multiple; Humans; Leukemia; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1994 |
Cyclosporin A, verapamil and S9788 reverse doxorubicin resistance in a human medullary thyroid carcinoma cell line.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Medullary; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Glutathione; Glutathione Transferase; Humans; Neoplasm Proteins; Piperidines; Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Thyroid Neoplasms; Triazines; Verapamil | 1995 |
[Quantitative cytological study of the activity of a new resistance modulator, S 9788, on human leukemic cells using multiparametric image analysis].
Topics: Animals; Antineoplastic Agents; Cytophotometry; DNA, Neoplasm; Drug Resistance, Multiple; Humans; Image Processing, Computer-Assisted; In Vitro Techniques; Mice; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |
Comparative evaluation of S9788, verapamil, and cyclosporine A in K562 human leukemia cell lines and in P-glycoprotein-expressing samples from patients with hematologic malignancies.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Doxorubicin; Drug Resistance; Female; Humans; Leukemia; Male; Membrane Glycoproteins; Middle Aged; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1994 |
Modulation of anthracycline accumulation and metabolism in rat hepatocytes in culture by three revertants of multidrug resistance.
Topics: Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cells, Cultured; Cyclosporine; Drug Resistance, Multiple; Liver; Male; Piperidines; Rats; Rats, Sprague-Dawley; Triazines; Up-Regulation; Verapamil | 1994 |
Inhibition of ion currents in membrane of sensory neuron by the antiarrhythmic drug BK 129 and selected Ca2+ entry blockers.
Topics: Animals; Anti-Arrhythmia Agents; Azepines; Calcium Channel Blockers; Carbamates; Ganglia, Spinal; Membrane Potentials; Neurons, Afferent; Nifedipine; Piperidines; Rats; Verapamil | 1993 |
Evaluation of S9788 as a potential modulator of drug resistance against human tumour sublines expressing differing resistance mechanisms in vitro.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Membrane Glycoproteins; Molecular Structure; Neoplasms; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine | 1993 |
[In vitro characterization of S9788, a new modulator of multidrug resistance].
Topics: Animals; Antineoplastic Agents; Cell Cycle; Drug Resistance; Drug Screening Assays, Antitumor; Humans; In Vitro Techniques; Mice; Neoplasms; Neoplasms, Experimental; Phenotype; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1993 |
Multidrug resistance circumvention by a new triazinoaminopiperidine derivative S9788 in vitro: definition of the optimal schedule and comparison with verapamil.
Topics: Antineoplastic Agents; Breast Neoplasms; Doxorubicin; Drug Resistance; Female; Humans; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1994 |
CP-99,994, a nonpeptide antagonist of the tachykinin NK1 receptor.
Topics: Albuterol; Animals; Binding, Competitive; Calcium Channels; Capsaicin; Dose-Response Relationship, Drug; Guinea Pigs; Kinetics; Lung; Neurokinin A; Neurokinin-1 Receptor Antagonists; Piperidines; Receptors, Neurokinin-1; Thiorphan; Verapamil | 1993 |
Differential effectiveness of a range of novel drug-resistance modulators, relative to verapamil, in influencing vinblastine or teniposide cytotoxicity in human lymphoblastoid CCRF-CEM sublines expressing classic or atypical multidrug resistance.
Topics: Cyclosporine; Dihydropyridines; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Flunarizine; Humans; Leukemia, T-Cell; Piperidines; Quinidine; Teniposide; Triazines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1994 |
Comparative efficacy of antiarrhythmic agents in preventing halothane-epinephrine arrhythmias in rats.
Topics: Amiodarone; Anesthesia, Inhalation; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Epinephrine; Flecainide; Halothane; Isoflurane; Lidocaine; Male; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Verapamil | 1993 |
A light stabilizer (Tinuvin 770) that elutes from polypropylene plastic tubes is a potent L-type Ca(2+)-channel blocker.
Topics: Alkaloids; Animals; Benzylisoquinolines; Binding, Competitive; Calcium Channel Blockers; Cell Line; Decanoic Acids; Dihydropyridines; Diltiazem; Guinea Pigs; Heart; In Vitro Techniques; Piperidines; Polypropylenes; Rabbits; Swine; Verapamil | 1993 |
Inhibition of Na+/Ca2+ overload with R 56,865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs.
Topics: Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Electrocardiography; Guinea Pigs; Heart Rate; Lidocaine; Male; Ouabain; Piperidines; Sodium; Tetrodotoxin; Thiazoles; Verapamil | 1993 |
R56865 is antifibrillatory in reperfused ischemic guinea-pig hearts, even when given only during reperfusion.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Benzothiazoles; Calcium; Calcium Channel Blockers; Extracellular Space; Guinea Pigs; Heart; In Vitro Techniques; Lidocaine; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Piperidines; Potassium; Sodium; Thiazoles; Verapamil | 1995 |
Effects of the hypoglycaemic drugs repaglinide and glibenclamide on ATP-sensitive potassium-channels and cytosolic calcium levels in beta TC3 cells and rat pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Carbamates; Cell Line; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; Ion Channel Gating; Islets of Langerhans; Kinetics; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Rats; Serum Albumin; Time Factors; Verapamil | 1995 |
[Effect of S9788, cyclosporin A and verapamil on intracellular accumulation of doxorubicin, daunorubicin and daunorubicinol in primary rat hepatocyte culture].
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Liver; Piperidines; Rats; Rats, Sprague-Dawley; Triazines; Verapamil | 1996 |
Relationship between the inhibition of azidopine binding to P-glycoprotein by MDR modulators and their efficiency in restoring doxorubicin intracellular accumulation.
Topics: Affinity Labels; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Cyclosporine; Cyclosporins; Dihydropyridines; Doxorubicin; Drug Resistance, Multiple; Humans; Mice; Nicardipine; Piperidines; Triazines; Tumor Cells, Cultured; Verapamil | 1996 |
Chemosensitization and drug accumulation effects of VX-710, verapamil, cyclosporin A, MS-209 and GF120918 in multidrug resistant HL60/ADR cells expressing the multidrug resistance-associated protein MRP.
Topics: Acridines; Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Etoposide; Fluoresceins; HL-60 Cells; Humans; Isoquinolines; Multidrug Resistance-Associated Proteins; Piperidines; Pyridines; Quinolines; Tetrahydroisoquinolines; Tritium; Verapamil; Vincristine | 1997 |
High affinity of sigma 1-binding sites for sterol isomerization inhibitors: evidence for a pharmacological relationship with the yeast sterol C8-C7 isomerase.
Topics: Animals; Binding Sites; Brain; Calcium Channel Blockers; Clomiphene; Estrogen Antagonists; Excitatory Amino Acid Antagonists; Fertility Agents, Female; Fungicides, Industrial; Guinea Pigs; Hypolipidemic Agents; Isoquinolines; Isotope Labeling; Microsomes; Microsomes, Liver; Morpholines; Pentazocine; Piperidines; Receptors, sigma; Saccharomyces cerevisiae; Stereoisomerism; Steroid Isomerases; Tamoxifen; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol; Verapamil | 1997 |
Simultaneous determination of cytotoxic (adriamycin, vincristine) and modulator of resistance (verapamil, S 9788) drugs in human cells by high-performance liquid chromatography and ultraviolet detection.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Chromatography, High Pressure Liquid; Doxorubicin; Drug Interactions; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; KB Cells; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Triazines; Verapamil; Vincristine | 1997 |
[Correlation of inhibition of thrombocyte light chain myosin phosphorylation and thrombocyte aggregation by the new calcium and calmodulin antagonist].
Topics: Blood Platelets; Calcium; Calcium Channel Blockers; Calmodulin; Humans; In Vitro Techniques; Myosin Light Chains; Phosphorylation; Piperidines; Platelet Aggregation Inhibitors; Sulfonamides; Verapamil | 1996 |
Comparison between technetium-99m-sestamibi and hydrogen-3-daunomycin myocardial cellular retention in vitro.
Topics: Animals; Animals, Newborn; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cyclosporins; Daunorubicin; Drug Resistance, Neoplasm; Genes, MDR; Heart; In Vitro Techniques; Myocardium; Piperidines; Radionuclide Imaging; Rats; Rats, Wistar; Technetium Tc 99m Sestamibi; Triazines; Tritium; Verapamil | 1997 |
Effect of a non-peptide NK-2 tachykinin receptor antagonist on LH, FSH, and prolactin release by rat hemipituitaries in vitro.
Topics: Animals; Benzamides; Castration; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; In Vitro Techniques; Luteinizing Hormone; Male; Ovariectomy; Piperidines; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Stereoisomerism; Testosterone; Verapamil | 1997 |
Evidence for reversal of multidrug resistance by quinine in LR73 cells without alteration of nuclear pirarubicin uptake and down-regulation of mdr1 gene expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Nucleus; CHO Cells; Cricetinae; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation; Genes, MDR; Piperidines; Quinine; Triazines; Verapamil | 1997 |
Combined potassium and calcium channel antagonistic activities as a basis for neutral frequency dependent increase in action potential duration: comparison between BRL-32872 and azimilide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Benzamides; Calcium Channel Blockers; Electric Stimulation; Guinea Pigs; Hydantoins; Imidazoles; Imidazolidines; In Vitro Techniques; Male; Membrane Potentials; Nitrendipine; Papillary Muscles; Piperazines; Piperidines; Potassium Channel Blockers; Pyridines; Random Allocation; Ryanodine; Verapamil | 1998 |
Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Astrocytes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Cattle; Coculture Techniques; Cyclosporine; Doxorubicin; Endothelium, Vascular; Immunosuppressive Agents; Piperidines; Predictive Value of Tests; Rats; Triazines; Verapamil; Vincristine | 1998 |
Confocal scanning microspectrofluorometry reveals specific anthracyline accumulation in cytoplasmic organelles of multidrug-resistant cancer cells.
Topics: Animals; Antibiotics, Antineoplastic; Cell Nucleus; CHO Cells; Cricetinae; Cytoplasm; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Golgi Apparatus; Humans; Microspectrophotometry; Piperidines; Quinine; Triazines; Tumor Cells, Cultured; Verapamil | 1998 |
Effects of low temperature on the chronotropic and inotropic responses to zatebradine, E-4031 and verapamil in isolated perfused dog atria.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Benzazepines; Calcium Channel Agonists; Cardiovascular Agents; Cold Temperature; Dogs; Dose-Response Relationship, Drug; Heart Atria; Hypothermia, Induced; In Vitro Techniques; Isoproterenol; Myocardial Contraction; Perfusion; Piperidines; Pyridines; Verapamil | 1998 |
Ischemia/reperfusion-induced arrhythmias in anaesthetized rats: a role of Na+ and Ca2+ influx.
Topics: Amiloride; Anesthesia; Animals; Arrhythmias, Cardiac; Benzothiazoles; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Heart Rate; Lidocaine; Male; Myocardial Reperfusion Injury; Piperidines; Rats; Rats, Wistar; Sodium; Sodium Channel Blockers; Sodium Channels; Thiazoles; Verapamil | 1999 |
Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyramide; Dogs; Electrocardiography; Flecainide; Injections; Lidocaine; Piperidines; Pyridines; Sodium Channels; Ventricular Fibrillation; Verapamil | 1999 |
Comparative 99mTc-sestamibi and 3H-daunomycin uptake in human carcinoma cells: relation to the MDR phenotype and effects of reversing agents.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cyclosporins; Daunorubicin; Drug Resistance, Multiple; Humans; Piperidines; Radiopharmaceuticals; Reverse Transcriptase Polymerase Chain Reaction; Technetium Tc 99m Sestamibi; Triazines; Tritium; Tumor Cells, Cultured; Verapamil | 1999 |
Effects of verapamil, zatebradine, and E-4031 on the pacemaker location and rate in response to sympathetic stimulation in dog hearts.
Topics: Animals; Anti-Arrhythmia Agents; Benzazepines; Cardiotonic Agents; Delayed Rectifier Potassium Channels; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Heart; Heart Atria; Heart Conduction System; Heart Rate; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Sinoatrial Node; Sympathetic Nervous System; Verapamil | 1999 |
Interplay between CYP3A-mediated metabolism and polarized efflux of terfenadine and its metabolites in intestinal epithelial Caco-2 (TC7) cell monolayers.
Topics: Anti-Anxiety Agents; Antifungal Agents; Aryl Hydrocarbon Hydroxylases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Catalytic Domain; Cell Polarity; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Digoxin; Enzyme Inhibitors; Epithelial Cells; Gene Expression; Histamine H1 Antagonists; Humans; Hydroxylation; Intestinal Mucosa; Intestines; Ketoconazole; Kinetics; Oligonucleotide Probes; Oxidoreductases, N-Demethylating; Piperidines; RNA, Messenger; Terfenadine; Tritium; Verapamil | 1999 |
Impaired potentiation by endothelin-1 and vasopressin of sympathetic contraction in tail artery from hypertensive rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Calcium Channel Blockers; Electric Stimulation; Endothelin Receptor Antagonists; Endothelin-1; Hypertension; In Vitro Techniques; Male; Norepinephrine; Oligopeptides; Peptides, Cyclic; Piperidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstriction; Vasopressins; Verapamil | 2000 |
Comparison of cardiovascular effects of a new calcium channel blocker AH-1058 with those of verapamil assessed in blood-perfused canine heart preparations.
Topics: Animals; Atrioventricular Node; Bridged Bicyclo Compounds; Calcium Channel Blockers; Dogs; Electrocardiography; Female; Heart; Hemodynamics; In Vitro Techniques; Male; Papillary Muscles; Piperidines; Sinoatrial Node; Verapamil | 2000 |
4-aminopyridine inhibits the occurrence of ventricular fibrillation but not ventricular tachycardia in the reperfused, P6olated rat heart.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Glyburide; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Reperfusion; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Torsades de Pointes; Ventricular Fibrillation; Verapamil | 2000 |
Cardiovascular action of a cardioselective Ca(2+)channel blocker AH-1058 in conscious dogs assessed by telemetry.
Topics: Animals; Atenolol; Blood Pressure; Bridged Bicyclo Compounds; Calcium Channel Blockers; Cardiovascular System; Consciousness; Disopyramide; Dogs; Heart Rate; Hemodynamics; Male; Piperidines; Substrate Specificity; Telemetry; Ventricular Pressure; Verapamil | 2001 |
Effect of P-glycoprotein on flavopiridol sensitivity.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; CHO Cells; Cisplatin; Colchicine; Colony-Forming Units Assay; Cricetinae; Drug Resistance, Multiple; Flavonoids; Paclitaxel; Piperidines; Quinidine; Verapamil | 2001 |
Release of non-neuronal acetylcholine from the isolated human placenta is mediated by organic cation transporters.
Topics: Acetylcholine; Amiloride; Cimetidine; Corticosterone; DNA, Antisense; Dose-Response Relationship, Drug; Female; Guanidine; Humans; In Vitro Techniques; Norepinephrine; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Piperidines; Placenta; Pregnancy; Procaine; Quinine; Time Factors; Verapamil | 2001 |
Frequency dependent prolongation of effective refractory period by a complex class III antiarrhythmic agent CPU-86017.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Benzeneacetamides; Berberine; Calcium Channel Blockers; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Papillary Muscles; Phenethylamines; Piperidines; Potassium Channel Blockers; Refractory Period, Electrophysiological; Sulfonamides; Verapamil | 2001 |
NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala.
Topics: Afferent Pathways; Amygdala; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cells, Cultured; Conditioning, Psychological; Fear; Kinetics; Long-Term Potentiation; Male; Memory; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Thalamus; Verapamil | 2002 |
The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment.
Topics: Animals; Anti-Arrhythmia Agents; Butylamines; Cisapride; Disease Models, Animal; Dogs; Female; Heart Rate; Long QT Syndrome; Male; Piperidines; Pyridines; Terfenadine; Verapamil | 2002 |
Contractile effect of acetylcholine on isolated ampullar segment of Fallopian tubes.
Topics: Acetylcholine; Adult; Aged; Diamines; Fallopian Tubes; Female; Follicular Phase; Humans; Lidocaine; Luteal Phase; Mecamylamine; Menopause; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Piperidines; Pirenzepine; Verapamil | 2004 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae.
Topics: Alanine; Animals; Biguanides; Calcium Channel Blockers; Cattle; D-Aspartic Acid; Diltiazem; Dizocilpine Maleate; Drug Synergism; Glucose; Glutamic Acid; Glycine; Humans; Kainic Acid; N-Methylaspartate; Nitrendipine; omega-Conotoxins; Perfusion; Piperidines; Polyamines; Receptors, Glutamate; Retina; Tritium; Verapamil | 2003 |
Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig.
Topics: Animals; Antipsychotic Agents; Bepridil; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Cisapride; Delayed Rectifier Potassium Channels; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gastrointestinal Agents; Guinea Pigs; Heart Rate; Histamine H1 Antagonists; Humans; In Vitro Techniques; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Potassium Channels, Voltage-Gated; Pyridines; Risperidone; Terfenadine; Verapamil | 2004 |
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil | 2004 |
Cellular and ionic mechanism for drug-induced long QT syndrome and effectiveness of verapamil.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cats; Chromans; Heart; Long QT Syndrome; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Sulfonamides; Tissue Culture Techniques; Torsades de Pointes; Verapamil | 2005 |
Thyroid hormone export from cells: contribution of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cell Line; Cell Membrane; Dogs; Drug Resistance, Multiple; Iodine Radioisotopes; Kidney; Nitrendipine; Piperidines; Pyridines; Transfection; Triiodothyronine; Verapamil | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
Allosteric modulation of 5-HT3 serotonin receptors.
Topics: Adrenergic alpha-Antagonists; Algorithms; Allosteric Regulation; Animals; Binding, Competitive; Cell Line, Tumor; Dose-Response Relationship, Drug; Granisetron; Hybrid Cells; Kinetics; Male; Mice; Models, Biological; Piperidines; Rats; Rats, Wistar; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Agents; Tritium; Verapamil | 2005 |
Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate.
Topics: Adenosine Triphosphatases; Animals; Anti-Allergic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Autoradiography; Biological Transport, Active; Brain; Chromatography, Liquid; Intestinal Absorption; Kinetics; LLC-PK1 Cells; Male; Mass Spectrometry; Mice; Mice, Knockout; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Stimulation, Chemical; Swine; Terfenadine; Verapamil | 2006 |
Diabetes mellitus reduces the antiarrhythmic effect of ion channel blockers.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Diabetes Mellitus; Diabetes Mellitus, Experimental; Epinephrine; Flecainide; Halothane; Ion Channels; Male; Piperidines; Potassium Channel Blockers; Pyridines; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Verapamil | 2006 |
In vivo evaluation of P-glycoprotein modulation of 8 PET radioligands used clinically.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cyclosporine; Donepezil; Flumazenil; Indans; Ligands; Male; Mice; Piperidines; Positron-Emission Tomography; Radioisotopes; Sensory Receptor Cells; Verapamil; Xanthines | 2007 |
Inotropic effects of ivabradine in the mammalian heart.
Topics: Adult; Aged; Aged, 80 and over; Animals; Benzazepines; Dose-Response Relationship, Drug; Electric Stimulation; Female; Heart Atria; Humans; Ivabradine; Male; Mice; Middle Aged; Myocardial Contraction; Piperidines; Species Specificity; Verapamil | 2010 |
Molecular mechanisms for the destabilization and restabilization of reactivated spatial memory in the Morris water maze.
Topics: Animals; Anisomycin; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Conditioning, Classical; Cyclic AMP Response Element-Binding Protein; Fear; Gene Expression; Hippocampus; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Piperidines; Protein Biosynthesis; Protein Synthesis Inhibitors; Pyrazoles; Receptors, N-Methyl-D-Aspartate; Rimonabant; Space Perception; Verapamil | 2011 |
Activation of M3 muscarinic receptor and Ca²⁺ influx by crude fraction from Crotonis Fructus in isolated rabbit jejunum.
Topics: Animals; Atropine; Calcium; Calcium Channel Blockers; Croton; Female; Fruit; In Vitro Techniques; Jejunum; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Piperidines; Plant Extracts; Rabbits; Receptor, Muscarinic M3; Solvents; Verapamil | 2012 |
Development of recombinant cell line co-expressing mutated Nav1.5, Kir2.1, and hERG for the safety assay of drug candidates.
Topics: Action Potentials; Biological Assay; Cell Line; Cisapride; Drug Evaluation, Preclinical; Ether-A-Go-Go Potassium Channels; HEK293 Cells; High-Throughput Screening Assays; Humans; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Pyridines; Pyrimidinones; Sodium Channels; Terfenadine; Transfection; Verapamil | 2012 |
Transmural dispersion of repolarization as a preclinical marker of drug-induced proarrhythmia.
Topics: Action Potentials; Animals; Bepridil; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Ether-A-Go-Go Potassium Channels; Heart Conduction System; Humans; In Vitro Techniques; Long QT Syndrome; Piperidines; Potassium Channel Blockers; Pyridines; Risk Assessment; Risperidone; Time Factors; Torsades de Pointes; Toxicity Tests; Verapamil; Voltage-Sensitive Dye Imaging | 2012 |
BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Calcium Channel Blockers; Camptothecin; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Cisplatin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Irinotecan; KB Cells; Liver Neoplasms; Male; Mice; Mice, Nude; Models, Molecular; Molecular Docking Simulation; Paclitaxel; Piperidines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triterpenes; Verapamil | 2012 |
Applications of minimal physiologically-based pharmacokinetic models.
Topics: Anti-Bacterial Agents; Antibodies, Monoclonal; beta-Lactams; Biological Availability; Carbamates; Codeine; Humans; Kinetics; Liver; Midazolam; Models, Biological; Piperidines; Regional Blood Flow; Verapamil | 2012 |
Bipiperidinyl derivatives of 23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Paclitaxel; Piperidines; Rhodamine 123; Triterpenes; Verapamil; Vincristine | 2013 |
[Effect of piperine on metablism and distribution of nortriptyline in mice].
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B; Benzodioxoles; Blood-Brain Barrier; Brain; Chromatography, High Pressure Liquid; Male; Mice; Nortriptyline; Piperidines; Polyunsaturated Alkamides; Tandem Mass Spectrometry; Verapamil | 2014 |
Image-based evaluation of contraction-relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: Correlation and complementarity with extracellular electrophysiology.
Topics: Adrenergic beta-Agonists; Biomechanical Phenomena; Calcium Channel Blockers; Calcium Signaling; Cell Differentiation; Cells, Cultured; Electrophysiologic Techniques, Cardiac; Humans; Induced Pluripotent Stem Cells; Isoproterenol; Kinetics; Microscopy, Video; Myocardial Contraction; Myocytes, Cardiac; Piperidines; Pyridines; Sodium Channel Blockers; Tetrodotoxin; Verapamil | 2014 |
A Simple Protocol for the Myocardial Differentiation of Human iPS Cells.
Topics: Activins; Bone Morphogenetic Protein 4; Calcium Channel Blockers; Carrier Proteins; Cell Differentiation; Cells, Cultured; Chromans; Embryoid Bodies; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Humans; Induced Pluripotent Stem Cells; Myocardium; Pentamidine; Piperidines; Potassium Channel Blockers; Pyridines; Sulfonamides; Transcription Factors; Troponin T; Verapamil; Wnt3A Protein | 2015 |
Interaction of mouse intestinal P-glycoprotein with oral antidiabetic drugs and its inhibitors.
Topics: Alkaloids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Transport, Active; Cyclohexanes; Fatty Acids, Unsaturated; Hypoglycemic Agents; Intestinal Mucosa; Mice; Molecular Docking Simulation; Piperidines; Polyunsaturated Alkamides; Protein Binding; Sesquiterpenes; Tamoxifen; Verapamil | 2015 |
Adverse event potentially due to an interaction between ibrutinib and verapamil: a case report.
Topics: Adenine; Aged; Antihypertensive Agents; Antineoplastic Agents; Cytochrome P-450 CYP3A Inhibitors; Diarrhea; Dihydropyridines; Drug Interactions; Humans; Lymphoma, Mantle-Cell; Male; Piperidines; Pyrazoles; Pyrimidines; Verapamil | 2016 |
Characterization of microminipigs as an in vivo experimental model for cardiac safety pharmacology.
Topics: Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiovascular Physiological Phenomena; Electrocardiography; Heart; Heart Rate; Infusions, Intravenous; Lidocaine; Piperidines; Pyridines; Swine; Swine, Miniature; Verapamil | 2017 |
Evaluation of the effects of power-frequency magnetic fields on the electrical activity of cardiomyocytes differentiated from human induced pluripotent stem cells.
Topics: Anti-Arrhythmia Agents; Calcium Channel Blockers; Cell Differentiation; Cell Line; Humans; Induced Pluripotent Stem Cells; Magnetic Fields; Myocytes, Cardiac; Piperidines; Pyridines; Verapamil | 2017 |
Efflux Attenuates the Antibacterial Activity of Q203 in Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Bacterial Proteins; Drug Resistance, Multiple, Bacterial; Imidazoles; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazines; Piperidines; Pyridines; Tuberculosis; Verapamil; Xanthenes | 2017 |
Absorptive and Secretory Transport of Selected Artemisinin Derivatives Across Caco-2 Cell Monolayers.
Topics: Alkaloids; Antimalarials; Artemisinins; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzodioxoles; Biological Transport; Caco-2 Cells; Humans; Permeability; Piperidines; Polyunsaturated Alkamides; Verapamil | 2018 |
Molecular modelling and simulation studies of the Mycobacterium tuberculosis multidrug efflux pump protein Rv1258c.
Topics: Alkaloids; Amino Acid Sequence; Antitubercular Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Benzodioxoles; Binding Sites; Drug Resistance, Multiple, Bacterial; Hydrogen Bonding; Molecular Docking Simulation; Molecular Dynamics Simulation; Mycobacterium tuberculosis; Piperidines; Polyunsaturated Alkamides; Principal Component Analysis; Protein Structure, Tertiary; Sequence Alignment; Thermodynamics; Verapamil | 2018 |
Novel virosecurinine bivalent mimetics as potent reversal agents against P-glycoprotein-mediated multidrug resistance.
Topics: Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azepines; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Heterocyclic Compounds, Bridged-Ring; Humans; Lactones; Male; Mice, Inbred BALB C; Mice, Nude; Piperidines; Verapamil | 2019 |
Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.
Topics: Acetamides; Albuterol; Animals; Carbamates; Chromatography, Liquid; Diazepam; Diclofenac; Digitoxin; Humans; Itraconazole; Ketoprofen; Liver; Metabolic Clearance Rate; Mice; Mice, Transgenic; Naproxen; Pharmaceutical Preparations; Phenytoin; Piperidines; Pravastatin; Pyrimidines; Quinidine; Tandem Mass Spectrometry; Telmisartan; Terfenadine; Verapamil | 2020 |
Intra-arterial combination therapy for experimental acute ischemic stroke.
Topics: Animals; Calcium Channel Blockers; Combined Modality Therapy; Infusions, Intra-Arterial; Ischemic Stroke; Mice; Mice, Inbred C57BL; Neuroprotective Agents; Piperidines; Thiazoles; Treatment Outcome; Verapamil | 2022 |
The interactive effects of verapamil and CB1 cannabinoid receptor antagonist/inverse agonist, AM251 on passive avoidance learning and memory in rat.
Topics: Animals; Avoidance Learning; Calcium; Calcium Channels, L-Type; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Endocannabinoids; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Verapamil | 2022 |