verapamil has been researched along with phenobarbital in 37 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (16.22) | 18.7374 |
| 1990's | 7 (18.92) | 18.2507 |
| 2000's | 14 (37.84) | 29.6817 |
| 2010's | 10 (27.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Lüllmann, H; Timmermans, PB; Weikert, GM; Ziegler, A | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD | 1 |
| Caron, G; Ermondi, G | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Akaike, N; Kameda, H; Kataoka, M; Takahashi, K; Ueno, S | 1 |
| De Sarro, A; De Sarro, GB; Nistico', G; Trimarchi, GR | 1 |
| Czuczwar, SJ; Kleinrok, Z; Małek, U | 1 |
| Ando, M; Bruyere, HJ; Gilbert, EF; Kajita, A; Nishikawa, T; Takao, A | 1 |
| Mirvis, DM; Pieper, JA; Rutledge, DR | 1 |
| Blouin, RA; Brouwer, KL; Chang, SL; Hamann, SR; Kaltenborn, KE; McAllister, RG; Tan, TG; Vore, M | 1 |
| Hauschild, R; Seewald, HJ | 1 |
| Chen, YH; Tsai, MC | 1 |
| Koleva, MR; Stoychev, TS | 1 |
| Beck, WT; Schuetz, EG; Schuetz, JD | 1 |
| Guo, YJ; He, P; Li, LF; Wu, MC; Yan, ZL | 1 |
| Fedrowitz, M; Löscher, W; Potschka, H | 1 |
| Kang, W; Weiss, M | 1 |
| Barac-Nieto, M; Constantinescu, A; Pina-Benabou, MH; Rozental, R | 1 |
| Liu, HY; Liu, X; Liu, XD; Liu, YC; Wang, GJ; Xie, L; Yang, HW; Zhang, DM | 1 |
| Baum, L; Kwan, P; Zhang, C; Zuo, Z | 1 |
| Jambroszyk, M; Potschka, H; Tipold, A | 1 |
| Li, J; Liu, L; Liu, XD; Pan, X; Wang, GJ; Xie, L; Yang, ZH; Yao, D; Yu, YL; Zhang, LL | 1 |
1 review(s) available for verapamil and phenobarbital
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
36 other study(ies) available for verapamil and phenobarbital
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Accumulation of drugs by guinea pig isolated atria. Quantitative correlations.
Topics: Animals; Chemistry, Pharmaceutical; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Myocardium; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Solubility; Time Factors | 1980 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Effects of Ca2+ antagonists and antiepileptics on tetrodotoxin-sensitive Ca(2+)-conducting channels in isolated rat hippocampal CA1 neurons.
Topics: Animals; Anticonvulsants; Calcium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Diltiazem; Dizocilpine Maleate; Dose-Response Relationship, Drug; Flunarizine; Hippocampus; Kinetics; Neurons; Nicardipine; Phenobarbital; Phenytoin; Pyramidal Tracts; Rats; Rats, Wistar; Sodium; Tetrodotoxin; Valproic Acid; Verapamil | 1992 |
Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Diltiazem; Drug Synergism; Flunarizine; Mice; Mice, Inbred DBA; Nimodipine; Phenobarbital; Phenytoin; Seizures; Valproic Acid; Verapamil | 1992 |
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Ethosuximide; Male; Mice; Nifedipine; Pentylenetetrazole; Phenobarbital; Reference Values; Seizures; Valproic Acid; Verapamil | 1990 |
Potentiating effects of verapamil on cardiovascular teratogenicity of phenobarbital in the chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Aorta; Calcium; Chick Embryo; Drug Synergism; Heart Defects, Congenital; Phenobarbital; Verapamil | 1988 |
Effects of chronic phenobarbital on verapamil disposition in humans.
Topics: Adult; Algorithms; Antipyrine; Humans; Male; Phenobarbital; Reference Values; Verapamil | 1988 |
Effects of phenobarbital and SKF-525A on in vitro hepatic metabolism of verapamil and nifedipine.
Topics: Animals; Cytochrome P-450 Enzyme System; In Vitro Techniques; Liver; Male; Metabolic Clearance Rate; Nifedipine; Phenobarbital; Proadifen; Rats; Rats, Inbred F344; Verapamil | 1985 |
[Spontaneous motility of the human fallopian tube and pharmacologic effect on it in a in-vitro study].
Topics: Adult; Diazepam; Ethanol; Fallopian Tubes; Female; Humans; In Vitro Techniques; Manometry; Middle Aged; Muscle Contraction; Muscle Relaxants, Central; Nylidrin; Perfusion; Phenobarbital; Pregnancy; Verapamil | 1974 |
Bursting firing of action potentials in central snail neurons elicited by d-amphetamine: role of the electrogenic sodium pump.
Topics: Action Potentials; Animals; Atropine; Dextroamphetamine; Dose-Response Relationship, Drug; Edetic Acid; Esophagus; Haloperidol; Hexamethonium; Magnesium; Neurons; Ouabain; Patch-Clamp Techniques; Phenobarbital; Potassium; Prazosin; Propranolol; Snails; Sodium; Sodium-Potassium-Exchanging ATPase; Temperature; Tubocurarine; Verapamil | 1995 |
Effect of nifedipine, verapamil and diltiazem on the enzyme-inducing activity of phenobarbital and beta-naphthoflavone.
Topics: Animals; Benzoflavones; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Induction; Male; Nifedipine; Oxidoreductases; Phenobarbital; Rats; Rats, Wistar; Verapamil | 1995 |
Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Base Sequence; Blotting, Northern; Cell Line; Clotrimazole; Colonic Neoplasms; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dexamethasone; DNA Primers; Doxorubicin; Gene Expression Regulation, Neoplastic; Humans; Midazolam; Mixed Function Oxygenases; Molecular Sequence Data; Multigene Family; Phenobarbital; Phenytoin; Polymerase Chain Reaction; Rifampin; Tumor Cells, Cultured; Verapamil | 1996 |
Chlorpromazine inhibits hepatocyte apoptosis caused by withdrawal of phenobarbital in mice.
Topics: Animals; Apoptosis; Aspirin; Calcium Channel Blockers; Calmodulin; Cell Division; Chlorpromazine; Cyclooxygenase Inhibitors; Liver; Male; Mice; Phenobarbital; Random Allocation; Verapamil | 1999 |
P-Glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Cerebral Cortex; Drug Resistance, Multiple; Epilepsy; Extracellular Space; Felbamate; Female; Lamotrigine; Microdialysis; Phenobarbital; Phenylcarbamates; Propylene Glycols; Rats; Rats, Wistar; Triazines; Up-Regulation; Verapamil | 2002 |
Modeling the metabolism of idarubicin to idarubicinol in rat heart: effect of rutin and phenobarbital.
Topics: Amiodarone; Animals; Antineoplastic Agents; Daunorubicin; Drug Design; Excitatory Amino Acid Antagonists; Heart; Idarubicin; Kinetics; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Rutin; Time Factors; Vasodilator Agents; Verapamil | 2003 |
Hypoxic rise in cytosolic calcium and renal proximal tubule injury mediated by a nickel-sensitive pathway.
Topics: Animals; Calcium; Calcium Channel Blockers; Cytoplasm; Female; GABA Modulators; Humans; Hypoxia; Kidney Tubules, Proximal; Nickel; Organ Culture Techniques; Pentobarbital; Phenobarbital; Rabbits; Tumor Cells, Cultured; Verapamil | 2004 |
Increased P-glycoprotein function and level after long-term exposure of four antiepileptic drugs to rat brain microvascular endothelial cells in vitro.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Carbamazepine; Cells, Cultured; Cerebral Arteries; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Endothelial Cells; Immunosuppressive Agents; Indicators and Reagents; Microcirculation; Phenobarbital; Phenytoin; Rats; Rhodamine 123; Sodium Channel Blockers; Time; Up-Regulation; Valproic Acid; Verapamil | 2008 |
In vitro concentration dependent transport of phenytoin and phenobarbital, but not ethosuximide, by human P-glycoprotein.
Topics: Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Calcium Channel Blockers; Cell Line; Dose-Response Relationship, Drug; Ethosuximide; Humans; In Vitro Techniques; Phenobarbital; Phenytoin; Rhodamine 123; Verapamil | 2010 |
Add-on treatment with verapamil in pharmacoresistant canine epilepsy.
Topics: Age of Onset; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Pressure; Bradycardia; Calcium Channel Blockers; Dog Diseases; Dogs; Drug Resistance; Drug Therapy, Combination; Epilepsy; Female; Male; Phenobarbital; Recurrence; Treatment Failure; Verapamil | 2011 |
Verapamil exerts biphasic modulation on phenobarbital transport across the blood-brain barrier: evidence from an in vivo and in vitro study.
Topics: Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Male; Mice; Mice, Inbred ICR; Microvessels; Phenobarbital; Rats; Rats, Sprague-Dawley; Time Factors; Vasodilator Agents; Verapamil | 2011 |