verapamil and perhexiline

verapamil has been researched along with perhexiline in 43 studies

Research

Studies (43)

TimeframeStudies, this research(%)All Research%
pre-199031 (72.09)18.7374
1990's2 (4.65)18.2507
2000's6 (13.95)29.6817
2010's4 (9.30)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M1
Keserü, GM1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Jia, L; Sun, H1
Caron, G; Ermondi, G; Visentin, S1
Sen, S; Sinha, N1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Sowton, E1
Breithaupt, H; Walter, P1
de Brito, FS; Pereira, MH1
De'Thomatis, M; Falciola, N; Gallesio, R1
Short, D1
Candau, LA; de Patta, M; Padilha, JC; Scherr, C; Tasca, R; Weiskopf, JS1
Attal, M; Bordier, C; Chatelain, P; Chiron, M; Jaffrézou, JP; Laurent, G; Levade, T; Thurneyssen, O1
Carrière, D; Chiron, M; Grandjean, H; Jaffrézou, JP; Kuhlein, E; Laurent, G; Levade, T; Thurneyssen, O1
Atkins, C; Bax, M; Psychoyos, S1
Martre, H; Singlas, E; Taburet, AM1
Briscoe, MG; Smith, HJ1
Barry, WH; Horowitz, JD; Smith, TW1
Opie, LH1
Fossati, C; Guistiniani, S1
Lewis, JG1
Donath, M; Ebner, F; Rämsch, KD1
Feely, J; Maclean, D1
Deierkauf, M; Elferink, JG1
Becker, HJ; Dowinsky, S; Hopf, R; Kaltenbach, M; Kober, G1
Oguro, K; Ono, H1
Forman, R; Kirk, ES1
Hashimoto, K; Ohara, N; Ono, H1
Dipalma, JR1
Hochrein, H; Lehmann, HU1
Antman, EM; Braunwald, E; Muller, JE; Stone, PH1
Hayakawa, H; Kimura, E; Kishida, H; Kusama, Y; Otsu, F; Takayama, M1
Kimura, M; Ono, H1
Bergey, JL; McCallum, JD; Nocella, K1
Nayler, WG1
Flaim, SF; Zelis, R1
Hashimoto, K; O'Hara, N; Ono, H1
Aziza, JP; Blanchard, D; Guermonprez, JL; Lancelin, B; Maurice, P1

Reviews

10 review(s) available for verapamil and perhexiline

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Treatment of angina pectoris (III)].
    Die Medizinische Welt, 1979, Feb-16, Volume: 30, Issue:7

    Topics: Angina Pectoris; Angina Pectoris, Variant; Coronary Artery Bypass; Humans; Nifedipine; Perhexiline; Prenylamine; Vasodilator Agents; Verapamil

1979
[Medical therapy of chronic coronary insufficiency].
    Bollettino della Societa italiana di cardiologia, 1978, Volume: 23, Issue:5

    Topics: Amiodarone; Angina Pectoris; Chronic Disease; Coronary Disease; Digitalis Glycosides; Humans; Lidoflazine; Oxyfedrine; Perhexiline; Practolol; Prenylamine; Verapamil

1978
[Clinical pharmacology of calcium inhibitors].
    Archives des maladies du coeur et des vaisseaux, 1985, Volume: 78 Spec No

    Topics: Age Factors; Animals; Bepridil; Biological Availability; Biotransformation; Calcium Channel Blockers; Diltiazem; Dogs; Half-Life; Humans; Intestinal Absorption; Kidney Failure, Chronic; Kinetics; Liver Diseases; Metabolic Clearance Rate; Nifedipine; Perhexiline; Protein Binding; Pyrrolidines; Rats; Tissue Distribution; Verapamil

1985
[Side-effects of calcium antagonists].
    La Clinica terapeutica, 1984, Jun-30, Volume: 109, Issue:6

    Topics: Calcium Channel Blockers; Cardiovascular Diseases; Drug Hypersensitivity; Drug Interactions; Fendiline; Gastrointestinal Diseases; Humans; Lidoflazine; Nervous System Diseases; Nifedipine; Perhexiline; Prenylamine; Verapamil

1984
Adverse reactions to calcium antagonists.
    Drugs, 1983, Volume: 25, Issue:2

    Topics: Calcium Channel Blockers; Diltiazem; Drug Interactions; Humans; Kinetics; Lidoflazine; Nifedipine; Perhexiline; Prenylamine; Risk; Verapamil

1983
Clinical differentiation of nifedipine and other calcium antagonists.
    Arquivos brasileiros de cardiologia, 1984, Volume: 43, Issue:1

    Topics: Biological Availability; Calcium Channel Blockers; Diltiazem; Drug Tolerance; Heart Diseases; Hemodynamics; Humans; Kinetics; Nifedipine; Perhexiline; Verapamil

1984
[Treatment of angina pectoris with calcium antagonists].
    Herz, 1982, Volume: 7, Issue:4

    Topics: Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Diltiazem; Drug Therapy, Combination; Exercise Test; Fendiline; Humans; Nicardipine; Nifedipine; Perhexiline; Prenylamine; Propafenone; Propiophenones; Verapamil

1982
[Indications for use of calcium antagonists].
    Medizinische Klinik, 1980, Apr-11, Volume: 75, Issue:8

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium; Cardiotonic Agents; Coronary Disease; Female; Fendiline; Humans; Hyperinsulinism; Hypertension; Nifedipine; Obstetric Labor, Premature; Paraganglioma; Perhexiline; Pregnancy; Prenylamine; Vasodilator Agents; Verapamil

1980
Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications.
    Annals of internal medicine, 1980, Volume: 93, Issue:6

    Topics: Benzazepines; Calcium Channel Blockers; Cardiovascular Diseases; Coronary Circulation; Diltiazem; Hemodynamics; Humans; Myocardial Contraction; Nifedipine; Nitrogen; Perhexiline; Piperidines; Pyridines; Regional Blood Flow; Vasodilation; Verapamil

1980

Trials

1 trial(s) available for verapamil and perhexiline

ArticleYear
[Verapamil in the treatment of angina pectoris. Double-blind study with clinical and ergometric evaluation].
    Arquivos brasileiros de cardiologia, 1979, Volume: 32, Issue:6

    Topics: Adult; Aged; Angina Pectoris; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Electrocardiography; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Perhexiline; Piperidines; Placebos; Verapamil

1979

Other Studies

32 other study(ies) available for verapamil and perhexiline

ArticleYear
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
    Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18

    Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2002
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
A two-state homology model of the hERG K+ channel: application to ligand binding.
    Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6

    Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation

2005
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:5

    Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship

2009
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
The treatment of angina pectoris.
    The Practitioner, 1979, Volume: 223, Issue:1336

    Topics: Adrenergic beta-Antagonists; Angina Pectoris; Coronary Angiography; Humans; Isosorbide Dinitrate; Middle Aged; Nifedipine; Nitroglycerin; Perhexiline; Physical Exertion; Prenylamine; Verapamil

1979
The management of the patient with angina.
    American heart journal, 1977, Volume: 94, Issue:2

    Topics: Angina Pectoris; Anticoagulants; Clofibrate; Coronary Artery Bypass; Diazepam; Digoxin; Humans; Isosorbide Dinitrate; Nitroglycerin; Oxprenolol; Perhexiline; Prenylamine; Propranolol; Verapamil

1977
Drug treatment of chronic stable angina pectoris.
    British medical journal, 1978, Feb-25, Volume: 1, Issue:6111

    Topics: Angina Pectoris; Chronic Disease; Humans; Nifedipine; Nitrites; Perhexiline; Verapamil

1978
[Comparative study of the medium term use of verapamil and perhexiline in the treatment of chronic coronary insufficiency. Clinical and cycloergometric evaluation].
    Arquivos brasileiros de cardiologia, 1978, Volume: 31 Suppl 1

    Topics: Adult; Aged; Chronic Disease; Coronary Disease; Electrocardiography; Exercise Test; Female; Humans; Male; Middle Aged; Perhexiline; Piperidines; Placebos; Verapamil

1978
In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction.
    Cancer research, 1992, Mar-01, Volume: 52, Issue:5

    Topics: Ammonium Chloride; Antibodies, Monoclonal; Dose-Response Relationship, Drug; Drug Synergism; Humans; Immunotoxins; Indolizines; Lipidoses; Lymphoma, T-Cell; Monensin; Perhexiline; Phenethylamines; Ricin; Tumor Cells, Cultured; Verapamil

1992
Enhancement of ricin A chain immunotoxin activity by perhexiline on established and fresh leukemic cells.
    Cancer research, 1990, Sep-01, Volume: 50, Issue:17

    Topics: Ammonium Chloride; Antibodies, Monoclonal; Cell Line; Humans; Immunotoxins; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Monensin; Neoplasm Proteins; Perhexiline; Ricin; Tumor Cells, Cultured; Verapamil

1990
Differences in Ca2+ entry blockers revealed by effects on adenosine- and adrenergic- receptors and cyclic AMP levels of [2-3H]adenine-prelabeled vesicles prepared from guinea pig brain.
    Biochemical pharmacology, 1986, May-15, Volume: 35, Issue:10

    Topics: Adenine; Adenosine; Animals; Arrhythmias, Cardiac; Brain Chemistry; Calcium Channel Blockers; Cell Membrane; Cyclic AMP; Epinephrine; Guinea Pigs; In Vitro Techniques; Nifedipine; Perhexiline; Prenylamine; Receptors, Adrenergic; Receptors, Cell Surface; Receptors, Purinergic; Stereoisomerism; Tritium; Verapamil

1986
The relative sensitization by acidosis of five calcium blockers in cat papillary muscles.
    Journal of molecular and cellular cardiology, 1985, Volume: 17, Issue:7

    Topics: Acidosis; Animals; Calcium Channel Blockers; Cats; Diltiazem; In Vitro Techniques; Lidoflazine; Myocardial Contraction; Nifedipine; Papillary Muscles; Perhexiline; Verapamil

1985
Comparison of negative inotropic potency, reversibility, and effects on calcium influx of six calcium channel antagonists in cultured myocardial cells.
    British journal of pharmacology, 1985, Volume: 85, Issue:1

    Topics: Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Gallopamil; Half-Life; Lidoflazine; Myocardial Contraction; Myocardium; Nifedipine; Perhexiline; Time Factors; Verapamil

1985
Drugs and the heart. III. Calcium antagonists.
    Lancet (London, England), 1980, Apr-12, Volume: 1, Issue:8172

    Topics: Angina Pectoris; Aniline Compounds; Arrhythmias, Cardiac; Calcium; Cardiomegaly; Diuretics; Heart Diseases; Heart Failure; Humans; Hypertension; Indapamide; Nifedipine; Perhexiline; Piperidines; Pyridines; Verapamil

1980
Calcium antagonists, nitrates, and new antianginal drugs.
    British medical journal (Clinical research ed.), 1983, Apr-02, Volume: 286, Issue:6371

    Topics: Angina Pectoris; Calcium Channel Blockers; Humans; Hypertension; Isosorbide Dinitrate; Lidoflazine; Nifedipine; Nitrates; Nitroglycerin; Perhexiline; Prenylamine; Tachycardia; Verapamil

1983
The effect of verapamil and other calcium antagonists on chemotaxis of polymorphonuclear leukocytes.
    Biochemical pharmacology, 1984, Jan-01, Volume: 33, Issue:1

    Topics: Animals; Calcium; Calcium Channel Blockers; Cell Survival; Chemotaxis, Leukocyte; Diltiazem; Gallopamil; Magnesium; Neutrophils; Perhexiline; Prenylamine; Rabbits; Verapamil

1984
Effects of perhexiline on contractile response of rabbit aorta to norepinephrine and potassium.
    European journal of pharmacology, 1980, Nov-07, Volume: 68, Issue:1

    Topics: Animals; Aorta, Thoracic; Drug Interactions; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nitroglycerin; Norepinephrine; Perhexiline; Piperidines; Potassium; Rabbits; Verapamil

1980
Comparative effects of vasodilator drugs on large and small coronary resistance vessels in the dog.
    Cardiovascular research, 1980, Volume: 14, Issue:10

    Topics: Animals; Coronary Vessels; Dogs; Nifedipine; Nitroglycerin; Nitroprusside; Perhexiline; Vascular Resistance; Vasodilator Agents; Verapamil

1980
Effect of an antianginal drug, perhexiline, on myocardial oxygen consumption in anesthetized open-chest dogs compared with verapamil and glyceryl trinitrate.
    Japanese circulation journal, 1982, Volume: 46, Issue:6

    Topics: Animals; Blood Pressure; Cardiac Surgical Procedures; Coronary Circulation; Dogs; Dose-Response Relationship, Drug; Heart Rate; Heart Ventricles; Myocardium; Nitroglycerin; Oxygen Consumption; Perhexiline; Piperidines; Verapamil

1982
Calcium channel blockers.
    American family physician, 1983, Volume: 27, Issue:2

    Topics: Angina Pectoris; Angina Pectoris, Variant; Arrhythmias, Cardiac; Calcium Channel Blockers; Diltiazem; Half-Life; Heart Diseases; Humans; Hypertension; Kinetics; Myocardial Infarction; Nifedipine; Perhexiline; Vasodilator Agents; Verapamil

1983
Effects of calcium antagonists, especially nifedipine, on variant angina, resting angina, and unstable angina.
    Japanese heart journal, 1982, Volume: 23, Issue:6

    Topics: Aged; Angina Pectoris; Angina Pectoris, Variant; Calcium Channel Blockers; Coronary Vasospasm; Diltiazem; Female; Humans; Male; Middle Aged; Nifedipine; Perhexiline; Prenylamine; Pyridines; Rest; Verapamil

1982
Effect of Ca2+-antagonistic vasodilators, diltiazem, nifedipine, perhexiline and verapamil, on platelet aggregation in vitro.
    Arzneimittel-Forschung, 1981, Volume: 31, Issue:7

    Topics: Adenosine Diphosphate; Adolescent; Adult; Calcium; Collagen; Diltiazem; Epinephrine; Humans; In Vitro Techniques; Male; Nifedipine; Perhexiline; Platelet Aggregation; Vasodilator Agents; Verapamil

1981
Antiarrhythmic evaluation of verapamil, nifedipine, perhexiline and skf 525-A in four canine models of cardiac arrhythmias.
    European journal of pharmacology, 1981, Mar-26, Volume: 70, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Calcium; Dogs; Female; Heart Rate; Lidocaine; Male; Myocardial Contraction; Nifedipine; Perhexiline; Piperidines; Proadifen; Pyridines; Verapamil

1981
Calcium antagonists.
    European heart journal, 1980, Volume: 1, Issue:3

    Topics: Angina Pectoris; Calcium Channel Blockers; Cell Membrane; Diltiazem; Heart; Humans; Hypertension; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Myocardial Infarction; Myocardium; Nifedipine; Perhexiline; Verapamil

1980
Clinical use of calcium entry blockers.
    Federation proceedings, 1981, Volume: 40, Issue:14

    Topics: Angina Pectoris; Calcium Channel Blockers; Cinnarizine; Coronary Circulation; Coronary Vasospasm; Diltiazem; Flunarizine; Heart Rate; Humans; Lidoflazine; Nifedipine; Perhexiline; Verapamil

1981
Effects of perhexiline on hemodynamics in anesthetized open-chest dogs.
    Japanese heart journal, 1981, Volume: 22, Issue:6

    Topics: Anesthesia; Animals; Blood Circulation; Blood Flow Velocity; Blood Pressure; Cardiac Output; Dogs; Dose-Response Relationship, Drug; Female; Heart Rate; Hemodynamics; Male; Norepinephrine; Perhexiline; Phentolamine; Piperidines; Propranolol; Verapamil

1981
[Calcium inhibitors. Current indications in cardiology].
    La Revue du praticien, 1980, Feb-01, Volume: 30, Issue:7

    Topics: Angina Pectoris; Arrhythmias, Cardiac; Calcium; Cardiovascular Diseases; Diltiazem; Humans; Nifedipine; Perhexiline; Prenylamine; Verapamil

1980