verapamil has been researched along with paclitaxel in 160 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (1.88) | 18.7374 |
| 1990's | 30 (18.75) | 18.2507 |
| 2000's | 57 (35.63) | 29.6817 |
| 2010's | 58 (36.25) | 24.3611 |
| 2020's | 12 (7.50) | 2.80 |
| Authors | Studies |
|---|---|
| Hosoyama, H; Kobayashi, J; Shigemori, H; Sudo, Y; Tsuruo, T; Wang, XX | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 2 |
| Belinsky, MG; Chen, ZS; Hopper-Borge, E; Kotova, E; Kruh, GD; Shchaveleva, I | 1 |
| Thakker, DR; Troutman, MD | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M | 1 |
| Collett, A; Hallifax, D; Tanianis-Hughes, J; Warhurst, G | 1 |
| Doi, T; Ishikawa, T; Nakagawa, H; Nakai, K; Takahashi, T; Yasunaga, M | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Ando, M; Furuya, Y; Hasegawa, T; Kakuta, S; Li, N; Sakai, J; Tomida, A; Tsuruo, T; Wang, LY; Wu, JL | 1 |
| Ando, M; Hasegawa, T; Kataoka, T; Kiuchi, M; Li, M; Li, N; Mitsui, T; Ogura, H; Oka, S; Sakai, J; Tang, W; Tomida, A; Turuo, T; Wu, JL | 1 |
| Burkett, BA; Chan, KF; Chan, TH; Chow, LM; Wong, IL; Zhao, Y | 1 |
| Abe, M; Ando, M; Bai, J; Hasegawa, T; Hirose, K; Kawakami, J; Kikuchi, M; Matsubara, J; Sakai, J; Tomida, A; Tsuruo, T; Wang, J; Zhang, S | 1 |
| Ando, M; Bai, LM; Furuya, Y; Hasegawa, T; Kakuta, S; Kataoka, T; Li, N; Ogura, H; Sakai, J; Tomida, A; Tsuruo, T; Wang, LY; Wu, JL | 2 |
| Abe, M; Ando, M; Bai, J; Bai, L; Bai, Y; Dai, J; Hasegawa, T; Hirose, K; Kikuchi, M; Nishizawa, S; Sakai, J; Tomida, A; Tsuruo, T; Yamori, T | 1 |
| Ahn, CM; Cho, S; Ham, J; Kim, H; Kim, SN; Kim, YK; Lee, S; Um, Y; Woo, HB | 1 |
| Chen, GY; Fong, WF; Globisch, C; Hu, YJ; Shen, XL; Tse, AK; Wiese, M; Yu, ZL; Zhu, GY | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Fong, WF; Fu, LC; Hu, YJ; Huang, XA; Lu, HL; Shen, XL; Zhang, YH | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Arya, KR; Bid, HK; Chaturvedi, JP; Chaudhary, P; Konwar, R; Narender, T; Nayak, VL; Reddy, KP | 1 |
| Choi, Y; Jin, Y; Jung, HY; Kaur, N; Kim, DK; Kim, EK; Kim, ES; Lee, K; Min, KH; Min, YK; Park, MK; Xia, Y | 1 |
| Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Aljancić, IS; Banković, J; Jadranin, M; Marković, ID; Milosavljević, G; Milosavljević, SM; Pesić, M; Povrenović, D; Ruzdijić, S; Tanić, N; Tesević, VV; Todorović, NM; Vajs, VE | 1 |
| Chan, KF; Chan, TH; Chow, LM; Kan, JW; Wong, IL; Yan, CS | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Ahn, S; Chen, J; Dalton, JT; Li, W; Lu, Y; Miller, DD; Wang, J | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chow, LM; Jiang, T; Wan, S; Wong, IL; Zhang, N; Zhang, Z | 1 |
| Chow, LM; Duan, LX; Hu, X; Jiang, T; Li, XM; Liu, T; Liu, Z; Wan, SB; Wang, BC; Wong, IL; Yuan, J; Zhang, XY | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Benavides, R; Cichewicz, RH; Du, L; Kuhn, JG; Li, J; Mooberry, SL; Risinger, AL; Robles, AJ | 1 |
| Atkins, WM; Li, MJ; Nath, A | 1 |
| Aisa, HA; Gao, J | 1 |
| Waghray, D; Zhang, Q | 1 |
| Cescon, DW; Hansen, MD; Hoj, JP; Siddiqui-Jain, A | 1 |
| Chen, ZS; Gupta, P; Lei, ZN; Li, YN; Li, ZH; Liu, HM; Liu, Y; Ma, LY; Wang, B; Wang, JQ; Zhang, XH; Zhao, B; Zhao, YD | 1 |
| Arnst, KE; Chen, H; Kumar, G; Li, W; Ma, D; Miller, DD; Wang, Q; Wang, Y; White, SW; Wu, Z; Yang, J | 1 |
| Chen, X; Chen, Y; Guo, Y; Lee, KH; Li, H; Morris-Natschke, S; Wan, Q; Wang, K | 1 |
| Chein, RJ; Chen, JJW; Cheng, TR; Chou, TH; Chung, WC; Hong, TM; Lee, TC; Lin, MS; Tsai, ML; Weng, CW; Wong, CH; Yang, PC; Yang, SC | 1 |
| Dubrovskyi, O; Dye, K; Gutgesell, LM; Huang, F; Li, Y; Ratia, K; Shen, Z; Thatcher, GRJ; Tonetti, DA; Xiong, R; Zhao, H; Zhao, J | 1 |
| Bi, Y; Chen, X; Huang, W; Li, X; Liang, K; Liu, S; Ma, M; Wang, B; Wang, H; Zeng, W | 1 |
| Bao, XZ; Cai, Y; Cui, ZN; Huang, Z; Li, YS; Liu, GJ; Wang, H; Wang, J; Wang, SJ; Wei, B; Wu, R; Yang, X; Ye, XY; Zhao, DS | 1 |
| Bi, Y; Cheng, H; Huang, W; Liu, S; Qiao, H; Tian, Q; Wang, H; Wang, L; Wang, R; Wang, Y; Xu, S | 1 |
| Cai, Z; Ghaleb, H; Huang, W; Jiang, Y; Liu, Y; Qian, H; Qiu, Q; Shi, W; Yin, Z; Zhang, P; Zhou, J; Zou, F | 1 |
| Gaertig, J; Gorovsky, MA; Heruth, DP; Stargell, LA | 1 |
| Gottesman, MM; Licht, T; Merlino, GT; Mickisch, GH; Pastan, I | 1 |
| Barlow, SB; Cabral, F; Schibler, MJ | 1 |
| Racker, E; Westcott, D; Wu, LT | 1 |
| Brewer, F; Warr, JR | 1 |
| Hunter, J; Jepson, MA; Simmons, NL | 1 |
| Balis, FM; Berg, SL; Cowan, KH; Denicoff, AM; Noone, M; O'Shaughnessy, JA; Ognibene, FP; Tolcher, A | 1 |
| Adler, KM; Brophy, NA; Fisher, GA; Halsey, J; Lum, BL; Sikic, BI; Yahanda, AM | 1 |
| Hudes, GR; Smith, CD; Tew, KD; Zhang, X; Zilfou, JT | 1 |
| Bates, SE; Dickstein, B; Fojo, AT; Lee, JS; Paull, K; Scala, S; Wilson, W; Zhan, Z | 1 |
| Hill, BT; Hosking, LK; McClean, S; Shellard, SA; Whelan, RD | 1 |
| Kumar, GN; McMillan, JM; Thornburg, KR; Walle, T; Walle, UK | 1 |
| Bhalla, K; Bullock, G; Huang, Y; Ibrado, AM; Mahoney, ME; Ponnathpur, V; Ray, S; Self, S; Tang, C; Tourkina, E | 1 |
| Dalton, WS; de Giuli, R; Emerson, S; Lehnert, M; Salmon, SE | 1 |
| Jachez, B; Loor, F; Nordmann, R | 1 |
| Hirst, BH; Hunter, J; Simmons, NL | 1 |
| Christopherson, RI; Roufogalis, BD; Syed, SK | 1 |
| Parekh, H; Simpkins, H | 2 |
| Balkenende, AY; Slaper-Cortenbach, IC; van den Berg, H; van der Schoot, CE; Van Leeuwen, EF; Vervoordeldonk, SF; von dem Borne, AE | 1 |
| Balis, FM; Barnes, CS; Berg, SL; Chang, R; Cowan, KH; Denicoff, AM; Fetsch, PA; Goldspiel, B; Gossard, MR; Noone, MH; O'Shaughnessy, JA; Ognibene, F; Solomon, D; Tolcher, AW; Venzon, DJ | 1 |
| Davey, MW; Davey, RA; Mote, PA; Oliver, L | 1 |
| Ogretmen, B; Safa, AR | 1 |
| Baguley, BC; Davey, MW; Davey, RA; Hargrave, RM; Harvie, RM; Su, GM | 1 |
| Alken, P; Köhrmann, KU; Kreukler, C; Nebe, T; Siegsmund, MJ; Steidler, A | 1 |
| Cannistra, SA; Chen, LB; Kraeft, SK; Strobel, T | 1 |
| Chan, MW; Chiang, CD; Song, EJ; Yang, VC | 1 |
| Gagandeep, S; Gupta, S; Novikoff, PM; Ott, M | 1 |
| Méndez-Vidal, C; Quesada, AR | 1 |
| Ghosh, A; Kapoor, P; Madhubala, R | 1 |
| Leist, M; Nicotera, P; Volbracht, C | 1 |
| Chabner, BA; Duan, Z; Feller, AJ; Penson, RT; Seiden, MV | 1 |
| Borst, P; Sarkadi, B; Smith, AJ; Szabo, K; Szakacs, G; van Helvoort, A; van Meer, G; Varadi, A; Welker, E | 1 |
| Atadja, P; Cohen, D; Roninson, IB; Uchiyama, N; Watanabe, T | 1 |
| Gewirtz, AM; Majka, M; Pertusini, E; Ratajczak, J; Ratajczak, MZ; Vaughn, D | 1 |
| Awasthi, S; Grady, JJ; Lin, JT; Sharma, R | 1 |
| Bible, KC; Boerner, SA; Kaufmann, SH; Tourne, ME | 1 |
| Appert, HE; Howard, JM; Iwamura, T; Liu, B; Staren, ED | 1 |
| Buchmann, B; Bunte, T; Hoffmann, J; Klar, U; Lichtner, RB; Rotgeri, A; Schwede, W; Skuballa, W | 1 |
| Bulinski, JC; Faire, K; Gruber, D | 1 |
| Crowe, A | 1 |
| Horinouchi, M; Komada, F; Nishiguchi, K; Ohmoto, N; Ohnishi, N; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y; Yokoyama, T | 1 |
| Hwang, SJ; Lee, CH; Shim, CK; Woo, JS | 1 |
| Kakumoto, M; Kita, T; Kobayashi, H; Nakamura, T; Okamura, N; Okumura, K; Sakaeda, T; Takara, K; Yagami, T | 1 |
| Cho, MC; Kim, DW; Kim, MS; Kim, YG; Kwon, JS; Lee, GS; Youn, TJ | 1 |
| Canevari, S; D'Ascenzo, S; Dolo, V; Millimaggi, D; Miotti, S; Pavan, A; Violini, S | 1 |
| Caprari, P; Catalano, A; Procopio, A; Rippo, MR; Rodilossi, S | 1 |
| Elliott, JI; Higgins, CF; Raguz, S | 1 |
| Choi, JS; Li, X | 1 |
| Ando, M; Bai, J; Bai, L; Dai, J; Fujisawa, H; Hirose, K; Ito, N; Kitabatake, M; Sakai, J; Tomida, A; Tsuruo, T; Zhang, S | 1 |
| Chen, J; Ehrlichova, M; Gut, I; Kovar, J; Kuznetsova, LV; Ojima, I; Pepe, A; Truksa, J; Vaclavikova, R | 1 |
| Bansal, T; Kaul, CL; Panchagnula, R; Varma, MV | 1 |
| Annable, T; Greenberger, LM; Hari, M; Loganzo, F; Morilla, DB; Musto, S; Nettles, JH; Snyder, JP; Tan, X | 1 |
| Jankovic, D; Kanazir, S; Markovic, ID; Markovic, JZ; Pesic, M; Rakic, L; Ruzdijic, S | 1 |
| Chavanpatil, MD; Panyam, J; Patil, Y | 1 |
| Hayeshi, R; Masimirembwa, C; Mukanganyama, S; Ungell, AL | 1 |
| Coop, A; Eddington, ND; Hassan, HE; Lee, IJ; Myers, AL | 1 |
| Ambudkar, SV; Barnett, D; Bates, SE; Finley, EM; Fojo, T; Oldham, RK; Robey, RW; Shukla, S | 1 |
| Burt, H; Elamanchili, P; McEachern, C | 1 |
| Chmielewski, J; Emmert, D; Hrycyna, CA; Pires, MM | 1 |
| Kawami, M; Nagai, J; Otani, Y; Takano, M; Tanda, M; Yumoto, R | 1 |
| Chen, X; Dai, J; Li, H; Li, Y; Qu, R; Su, F; Wang, H; Yin, D; Zhang, Y | 1 |
| Castro, CH; Hughes, JA; Nguyen, N; Niu, G; Sullivan, SM | 1 |
| Choy, E; Duan, Z; Hornicek, F; Mankin, H; Schwab, J; Susa, M; Yang, C | 1 |
| Junyaprasert, VB; Kawami, M; Nagai, J; Patanasethanont, D; Soonthornchareonnon, N; Sripanidkulchai, BO; Takano, M; Yumoto, R | 1 |
| Akyol, A; Fearon, ER; Hinoi, T; Kawaguchi, Y; Ohdan, H; Okajima, M; Oue, N; Sasada, T; Takakura, Y; Yasui, W | 1 |
| Jin, X; Ju, C; Li, N; Mo, R; Ping, Q; Sun, M; Zhang, C | 1 |
| Chen, Y; Duan, C; Hao, L; Jia, L; Liu, G; Liu, Y; Wang, F; Zhang, D; Zhang, Q; Zheng, D | 1 |
| Chen, Q; Chen, Y; Deng, W; Jin, S; Li, S; Tong, Q; Wang, Y | 1 |
| Ambudkar, SV; Bhatnagar, J; Chen, JJ; Chen, WM; Chen, ZS; Lan, P; Ruan, ZX; Shu, C; Sodani, K; Wang, J; Xiao, ZJ; Ye, WC; Zhang, DM | 1 |
| Covell, DG | 1 |
| Baek, JS; Cho, CW | 2 |
| Ishigami, M; Kimura, Y; Kioka, N; Matsuo, M; Nagao, K; Tominaga, Y; Ueda, K | 1 |
| Liu, F; Racette, K; Tang, J; Wang, D; Wang, Y; Xu, Z | 1 |
| Chen, WM; Chen, ZS; Fu, LW; Fung, KP; Lan, P; Li, YJ; Peng, YH; Ruan, ZX; Shu, C; Wang, J; Yao, Z; Ye, WC; Yiu, A; Zhang, DM | 1 |
| Li, CC; Lü, HX; Zhang, YL; Zhang, ZH; Zhou, JP | 1 |
| Guo, C; Han, Y; Li, Y; Meng, X; Shen, Z; Wan, L; Yang, Q; Yu, Q; Zhou, Z | 1 |
| Ge, J; Li, LB; Li, N; Li, Y; Zhao, Y | 1 |
| Ahmadi, F; Mohammadi-Samani, S; Montaseri, H; Sobhani, Z; Zarea, B | 1 |
| Cadagan, D; Merry, S | 1 |
| An, D; Cai, Q; Deng, X; Li, Z; Shen, T; Zhong, M | 1 |
| Chong, Y; Choo, H; Kim, MK | 1 |
| Akiyama, K; Alam, MT; Hida, K; Hida, Y; Kawamoto, T; Maishi, N; Ohba, Y; Ohga, N; Ohmura, H; Shindoh, M; Torii, C; Yamada, K | 1 |
| Li, M; Liu, S; Peng, L; Wang, S; Yang, F | 1 |
| Bray, SE; Chakravarty, P; Ferguson, MJ; Gannon, AL; Sawers, L; Scott, AL; Smith, G; Vaidyanathan, A | 1 |
| Fereira, N; Godfrey, L; Odunze, U; Sasaki, K; Schätzlein, A; Soundararajan, R; Uchegbu, I | 1 |
| Carvalho, VFM; Costa, SKP; Giacone, DV; Lopes, LB | 1 |
| Chen, Q; Fu, Y; Huo, M; Li, L; Liu, Y; Mu, Y; Xu, W; Yin, T; Zhou, J | 1 |
| Horwitz, SB; Ojima, I; Wang, C; Yang, CH | 1 |
| Bae, EJ; Lee, MK; Xu, W | 1 |
| Chu, K; Guo, Y; Han, L; Li, T; Ouyang, H; Qiu, L; Wang, X; Xu, W | 1 |
| Hou, S; Ju, C; Qu, D; Qu, G; Tian, C; Xue, L; Zhang, C; Zhu, J | 1 |
| Abel, B; Ambudkar, SV; Durell, SR; Jacobson, KA; Murakami, M; Tosh, DK; Vahedi, S | 1 |
| Gong, PY; Li, P; Zhong, D | 1 |
| Chu, K; Han, L; Li, T; Ouyang, H; Qiu, L; Wang, X; Xu, W; Zhang, X | 1 |
| Cai, CY; Chen, ZS; Lei, ZN; Teng, QX; Wang, J; Wang, JQ; Wu, ZX; Yang, DH; Yang, Y; Zhao, L | 1 |
| Hammer, HS; Khalaf, S; Kroetz, DL; Mortensen, C; Nielsen, F; Poetz, O; Rodriguez-Antona, C; Stage, TB; Steffensen, V; Svenningsen, ÅF; Xiong, C | 1 |
| Gao, M; Wang, K; Wang, X; Wang, Z; Xu, X; Zhang, H | 1 |
| Meeran, SM; Mondal, P; Natesh, J; Penta, D | 1 |
| Goto, M; Lee, KH; Ohkoshi, E; Wada, K; Yamashita, H | 1 |
| Chen, Y; Li, M; Liu, H; Qu, F; Wan, Q; Wang, W | 1 |
| Ando, M; Bai, J; Dai, J; Hasegawa, T; Hirose, K; Kiuchi, M; Li, M; Nishizawa, S; Oka, S; Sakai, J; Tomida, A; Tsuruo, T | 1 |
| Chen, XG; Dai, JG; Jia, HT; Xie, D; Yan, YN; Yin, DL; Zhang, Y; Zou, JH | 1 |
| Chen, X; Gu, J; Huang, M; Yin, D; Zhang, M; Zhao, X | 1 |
5 review(s) available for verapamil and paclitaxel
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Neoplasm; Humans; Protein Conformation | 2018 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Multiple; Etoposide; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel; Pharmaceutical Preparations; Verapamil | 1994 |
Reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Clinical Trials as Topic; Drug Resistance, Multiple; Humans; Neoplasms; Paclitaxel; Tumor Cells, Cultured; Verapamil; Vincristine | 1994 |
4 trial(s) available for verapamil and paclitaxel
| Article | Year |
|---|---|
Effect of R-verapamil on the pharmacokinetics of paclitaxel in women with breast cancer.
Topics: Breast Neoplasms; Chromatography, High Pressure Liquid; Cross-Over Studies; Drug Therapy, Combination; Female; Humans; Metabolic Clearance Rate; Paclitaxel; Verapamil | 1995 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Multiple; Etoposide; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel; Pharmaceutical Preparations; Verapamil | 1994 |
Phase I crossover study of paclitaxel with r-verapamil in patients with metastatic breast cancer.
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biopsy; Breast Neoplasms; Cross-Over Studies; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Middle Aged; Paclitaxel; Treatment Outcome; Verapamil | 1996 |
Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
Topics: Adenosine Triphosphatases; Alkaloids; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azides; Biological Factors; Biological Transport; Cell Line; Cell Line, Tumor; Cyclosporins; Depsipeptides; Fluorescent Dyes; Fluorouracil; Humans; Insecta; Multidrug Resistance-Associated Proteins; Neoplasms; Paclitaxel; Prazosin; Quinolines; Rhodamine 123; Verapamil; Vinblastine | 2008 |
152 other study(ies) available for verapamil and paclitaxel
| Article | Year |
|---|---|
Modulation of multidrug resistance by taxuspine C and other taxoids from Japanese yew.
Topics: Animals; Bridged-Ring Compounds; Carcinoma, Squamous Cell; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Leukemia L1210; Leukemia P388; Mice; Phenylpropionates; Taxoids; Trees; Tumor Cells, Cultured; Vincristine | 1998 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10).
Topics: Biological Transport; Cells, Cultured; Cyclosporine; Estradiol; Glycocholic Acid; Humans; Kinetics; Leukotriene Antagonists; Leukotriene C4; Multidrug Resistance-Associated Proteins; Osmotic Pressure; Propionates; Quinolines; Recombinant Proteins; Transfection | 2003 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies.
Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity | 2004 |
Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Caco-2 Cells; Cell Membrane Permeability; Humans; Intestinal Absorption; Mice; Mice, Knockout; Pharmacokinetics; Spectrometry, Mass, Electrospray Ionization | 2004 |
Synthesis and evaluation of 3D templates based on a taxane skeleton to circumvent P-glycoprotein-associated multidrug resistance of cancer.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Bridged-Ring Compounds; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Taxoids | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Bioactive dibenzylbutyrolactone and dibenzylbutanediol lignans from Peperomia duclouxii.
Topics: Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Inhibitory Concentration 50; Lignans; Molecular Structure; Peperomia; Plants, Medicinal; Tumor Cells, Cultured; Verapamil | 2006 |
Bioactive secolignans from Peperomia dindygulensis.
Topics: Antineoplastic Agents, Phytogenic; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Intercellular Adhesion Molecule-1; Lignans; Molecular Structure; Peperomia; Plants, Medicinal | 2006 |
Flavonoid dimers as bivalent modulators for P-glycoprotein-based multidrug resistance: synthetic apigenin homodimers linked with defined-length poly(ethylene glycol) spacers increase drug retention and enhance chemosensitivity in resistant cancer cells.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents; Apigenin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Dimerization; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Paclitaxel; Polyethylene Glycols; Structure-Activity Relationship; Vinblastine | 2006 |
Structure-activity relationships of some taxoids as multidrug resistance modulator.
Topics: Alkaloids; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Structure-Activity Relationship; Taxoids; Taxus | 2007 |
Bioactive lignans from Peperomia duclouxii.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Female; Humans; Intercellular Adhesion Molecule-1; Interleukin-1alpha; Lignans; Peperomia; Plants, Medicinal; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2007 |
Synthesis and structure-activity relationships of taxuyunnanine C derivatives as multidrug resistance modulator in MDR cancer cells.
Topics: Antineoplastic Agents; Biological Assay; Cell Line; Cell Line, Tumor; Chemistry, Pharmaceutical; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fluoresceins; Humans; Inhibitory Concentration 50; Models, Chemical; Structure-Activity Relationship; Taxoids | 2007 |
Bioactive polyketides from Peperomia duclouxii.
Topics: Cyclohexanones; Drugs, Chinese Herbal; Female; Fluoresceins; Humans; Inhibitory Concentration 50; Intercellular Adhesion Molecule-1; Interleukin-1alpha; Molecular Structure; Peperomia; Plants, Medicinal; Sesquiterpenes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Verapamil | 2007 |
Synthesis of curcumin mimics with multidrug resistance reversal activities.
Topics: Cell Line, Tumor; Cell Survival; Cross-Linking Reagents; Curcumin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Structure; Stereoisomerism | 2008 |
Methoxylation of 3',4'-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Coumarins; Drug Resistance, Multiple; Humans; Molecular Structure; Neoplasms; Oxygen; Pyranocoumarins; Pyrans; Sensitivity and Specificity; Structure-Activity Relationship; Substrate Specificity | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Tenacigenin B derivatives reverse P-glycoprotein-mediated multidrug resistance inHepG2/Dox cells.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Marsdenia; Multidrug Resistance-Associated Proteins; Paclitaxel; Plants, Medicinal; Puromycin; Steroids; Vinblastine | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
In vitro and in vivo anticancer activity of 2-deacetoxytaxinine J and synthesis of novel taxoids and their in vitro anticancer activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line; Cell Line, Tumor; Epithelial Cells; Female; Humans; Inhibitory Concentration 50; Kidney; Plant Bark; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Taxoids; Taxus | 2009 |
A novel class of highly potent multidrug resistance reversal agents: disubstituted adamantyl derivatives.
Topics: Adamantane; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P-450 CYP3A; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Sarcoma; Structure-Activity Relationship | 2009 |
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Isolation and biological evaluation of jatrophane diterpenoids from Euphorbia dendroides.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Diterpenes; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Euphorbia; Humans; Montenegro; Nuclear Magnetic Resonance, Biomolecular; Paclitaxel | 2011 |
Amine linked flavonoid dimers as modulators for P-glycoprotein-based multidrug resistance: structure-activity relationship and mechanism of modulation.
Topics: Adenosine Triphosphatases; Amines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzylamines; Cell Line, Tumor; Dimerization; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flavones; Flavonoids; Humans; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Paclitaxel; Polyethylene Glycols; Solubility; Structure-Activity Relationship | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery of novel 2-aryl-4-benzoyl-imidazole (ABI-III) analogues targeting tubulin polymerization as antiproliferative agents.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Imidazoles; Male; Melanoma; Models, Molecular; Paclitaxel; Prostatic Neoplasms; Structure-Activity Relationship; Tubulin Modulators | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
4,5-Di-substituted benzyl-imidazol-2-substituted amines as the structure template for the design and synthesis of reversal agents against P-gp-mediated multidrug resistance breast cancer cells.
Topics: Amines; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Imidazoles; Mice | 2014 |
Potent and Nontoxic Chemosensitizer of P-Glycoprotein-Mediated Multidrug Resistance in Cancer: Synthesis and Evaluation of Methylated Epigallocatechin, Gallocatechin, and Dihydromyricetin Derivatives.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Catechin; Cell Proliferation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flavonols; Humans; Methylation; Models, Molecular; Molecular Structure; Neoplasm Proteins; Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2015 |
Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.
Topics: Animals; Antineoplastic Agents, Phytogenic; Humans; Microtubules; Molecular Structure; Steroids; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2017 |
Differential Coupling of Binding, ATP Hydrolysis, and Transport of Fluorescent Probes with P-Glycoprotein in Lipid Nanodiscs.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Binding, Competitive; Biological Transport; Boron Compounds; Dimyristoylphosphatidylcholine; Fluorescent Dyes; Humans; Hydrolysis; Kinetics; Ligands; Lipid Bilayers; Mice; Models, Molecular; Nanostructures; Protein Conformation; Recombinant Fusion Proteins; Recombinant Proteins; Taxoids; Verapamil; Vinblastine | 2017 |
Terpenoids from Euphorbia soongarica and Their Multidrug Resistance Reversal Activity.
Topics: Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Diterpenes; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Euphorbia; Humans; KB Cells; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Terpenes | 2017 |
Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization.
Topics: Amides; Animals; Cell Line, Tumor; Cell Proliferation; Dogs; Dose-Response Relationship, Drug; Humans; Mice; Microsomes, Liver; Microtubules; Molecular Structure; Neoplasms, Experimental; Polymerization; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship | 2018 |
Discovery of 5-Cyano-6-phenylpyrimidin Derivatives Containing an Acylurea Moiety as Orally Bioavailable Reversal Agents against P-Glycoprotein-Mediated Mutidrug Resistance.
Topics: Administration, Oral; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Multiple; Gene Expression Regulation, Neoplastic; Humans; Intracellular Space; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Protein Transport; Pyrimidines; Urea | 2018 |
Structural Modification of the 3,4,5-Trimethoxyphenyl Moiety in the Tubulin Inhibitor VERU-111 Leads to Improved Antiproliferative Activities.
Topics: Animals; Cell Proliferation; Chalcones; Humans; Male; Melanoma; Mice; Mice, Nude; Models, Molecular; Molecular Structure; Prostatic Neoplasms; Protein Conformation; Tubulin; Tubulin Modulators; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2018 |
Seco-4-methyl-DCK derivatives as potent chemosensitizers.
Topics: Antineoplastic Agents; Cell Line; Cell Proliferation; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship | 2019 |
4(1H)-quinolone derivatives overcome acquired resistance to anti-microtubule agents by targeting the colchicine site of β-tubulin.
Topics: Antineoplastic Agents; Apoptosis; Binding Sites; Cell Proliferation; Colchicine; Drug Resistance, Neoplasm; Humans; Molecular Docking Simulation; Neoplasms; Quinolones; Tubulin; Tubulin Modulators | 2019 |
Novel Pyrrolopyridone Bromodomain and Extra-Terminal Motif (BET) Inhibitors Effective in Endocrine-Resistant ER+ Breast Cancer with Acquired Resistance to Fulvestrant and Palbociclib.
Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Fulvestrant; Humans; MCF-7 Cells; Mice; Models, Molecular; Piperazines; Protein Domains; Pyridines; Pyridones; Receptors, Estrogen; Tissue Distribution; Transcription Factors; Xenograft Model Antitumor Assays | 2020 |
Design, synthesis, and biological evaluation of hederagenin derivatives with improved aqueous solubility and tumor resistance reversal activity.
Topics: Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Molecular Structure; Oleanolic Acid; Structure-Activity Relationship | 2021 |
Design, synthesis and bioactivity study on 5-phenylfuran derivatives as potent reversal agents against P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Design; Drug Resistance, Neoplasm; Furans; Humans; Molecular Docking Simulation; Paclitaxel; Structure-Activity Relationship; Tetrahydroisoquinolines | 2021 |
Design, synthesis, and tumor drug resistance reversal activity of novel hederagenin derivatives modified by nitrogen-containing heterocycles.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Mice, Nude; Nitrogen; Oleanolic Acid | 2022 |
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel | 2022 |
Drugs affecting microtubule dynamics increase alpha-tubulin mRNA accumulation via transcription in Tetrahymena thermophila.
Topics: Alkaloids; Animals; Colchicine; Cytochalasin B; Dinitrobenzenes; Dose-Response Relationship, Drug; Food Deprivation; Immunohistochemistry; Microtubules; Paclitaxel; RNA, Messenger; Sulfanilamides; Tetrahymena thermophila; Transcription, Genetic; Tubulin; Verapamil | 1992 |
Chemotherapy and chemosensitization of transgenic mice which express the human multidrug resistance gene in bone marrow: efficacy, potency, and toxicity.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow; Daunorubicin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Tolerance; Intestines; Leukocyte Count; Liver; Membrane Glycoproteins; Mice; Mice, Transgenic; Paclitaxel; Spleen; Verapamil; Vinblastine; Vincristine | 1991 |
Elimination of permeability mutants from selections for drug resistance in mammalian cells.
Topics: Alkaloids; Animals; Cell Line; Cell Membrane Permeability; Colchicine; Cricetinae; Drug Resistance; Griseofulvin; In Vitro Techniques; Microtubules; Paclitaxel; Selection, Genetic; Tubulin; Verapamil; Vinblastine | 1989 |
Use of slow Ca2+ channel blockers to enhance inhibition by taxol of growth of drug-sensitive and -resistant Chinese hamster ovary cells.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Calcium Channel Blockers; Cell Division; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Nicotinic Acids; Nimodipine; Ovary; Paclitaxel; Pimozide; Verapamil | 1986 |
Verapamil reversal of vincristine resistance and cross-resistance patterns of vincristine-resistant Chinese hamster ovary cells.
Topics: Alkaloids; Animals; Cell Line; Doxorubicin; Drug Interactions; Drug Resistance; Mutation; Paclitaxel; Phenotype; Verapamil; Vinca Alkaloids; Vincristine | 1987 |
Targeted delivery of a substrate for P-glycoprotein to renal cysts in vitro.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Drug Carriers; Kidney Diseases, Cystic; Microscopy, Confocal; Paclitaxel; Tritium; Verapamil; Vinblastine | 1995 |
Modulation of P-glycoprotein activity by estramustine is limited by binding to plasma proteins.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Proteins; Breast Neoplasms; Carcinoma; Dialysis; Drug Resistance, Multiple; Estramustine; Gene Expression Regulation, Neoplastic; Humans; Orosomucoid; Paclitaxel; Protein Binding; Serum Albumin; Tritium; Tumor Cells, Cultured; Verapamil; Vinblastine | 1995 |
Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Cricetinae; DNA Topoisomerases, Type II; Docetaxel; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Paclitaxel; Taxoids; Tumor Cells, Cultured; Verapamil | 1994 |
Taxol metabolism in rat hepatocytes.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Kinetics; Liver; Male; Mass Spectrometry; Midazolam; Paclitaxel; Phenacetin; Rats; Verapamil | 1993 |
Characterization of a human myeloid leukemia cell line highly resistant to taxol.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Division; Cyclosporine; Daunorubicin; DNA, Neoplasm; Drug Resistance; Humans; Leukemia, Myeloid; Membrane Glycoproteins; Microtubules; Paclitaxel; Tumor Cells, Cultured; Verapamil | 1994 |
In vitro evaluation of chemosensitizers for clinical reversal of P-glycoprotein-associated Taxol resistance.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Drug Resistance; Humans; Membrane Glycoproteins; Multiple Myeloma; Paclitaxel; Quinine; Trifluoperazine; Tumor Cells, Cultured; Verapamil | 1993 |
Restoration of taxol sensitivity of multidrug-resistant cells by the cyclosporine SDZ PSC 833 and the cyclopeptolide SDZ 280-446.
Topics: Animals; Antineoplastic Agents; CHO Cells; Cricetinae; Cyclosporins; Drug Resistance; Leukemia P388; Mice; Paclitaxel; Peptides, Cyclic; Tumor Cells, Cultured; Verapamil | 1993 |
Drug absorption limited by P-glycoprotein-mediated secretory drug transport in human intestinal epithelial Caco-2 cell layers.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Colforsin; Docetaxel; Epithelium; Humans; Intestinal Absorption; Intestinal Mucosa; Membrane Glycoproteins; Nifedipine; Paclitaxel; Taxoids; Tumor Cells, Cultured; Verapamil; Vinblastine | 1993 |
Vinblastine transport by membrane vesicles from human multidrug-resistant CCRF-CEM leukaemia cells: inhibition by taxol and membrane permeabilising agents.
Topics: Alamethicin; Cell Membrane; Cell Membrane Permeability; Drug Resistance; Humans; Leukemia, Lymphoid; Octoxynol; Osmolar Concentration; Paclitaxel; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured; Verapamil; Vinblastine | 1993 |
Species-specific differences in taxol transport and cytotoxicity against human and rodent tumor cells. Evidence for an alternate transport system.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Survival; Drug Resistance, Multiple; Humans; Microtubule Proteins; Paclitaxel; Rats; Species Specificity; Tubulin; Tumor Cells, Cultured; Verapamil | 1996 |
Cross-resistance and collateral sensitivity to natural product drugs in cisplatin-sensitive and -resistant rat lymphoma and human ovarian carcinoma cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Survival; Cisplatin; Colchicine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Glutathione; Humans; Lymphoma; Methionine Sulfoximine; Mitosis; Ovarian Neoplasms; Paclitaxel; Rats; Tumor Cells, Cultured; Verapamil; Vinca Alkaloids | 1996 |
Degradation of radioiodinated B cell monoclonal antibodies: inhibition via a FCgamma-receptor-II-mediated mechanism and by drugs.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Antigens, CD19; Antigens, Differentiation, B-Lymphocyte; Antineoplastic Agents; B-Lymphocytes; Biological Transport; Burkitt Lymphoma; Calcium Channel Blockers; Cell Adhesion Molecules; Chloroquine; Colchicine; Etoposide; Humans; Immunoglobulin Isotypes; Immunotoxins; Iodine Radioisotopes; Lectins; Leukemia, B-Cell; Mice; Monensin; Paclitaxel; Radioimmunotherapy; Receptors, IgG; Sialic Acid Binding Ig-like Lectin 2; Verapamil; Vinblastine; Vincristine | 1996 |
Paclitaxel sensitizes multidrug resistant cells to radiation.
Topics: Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Death; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Leukemia, Promyelocytic, Acute; Paclitaxel; Radiation-Sensitizing Agents; Time Factors; Tumor Cells, Cultured; Verapamil | 1996 |
Down-regulation of apoptosis-related bcl-2 but not bcl-xL or bax proteins in multidrug-resistant MCF-7/Adr human breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Base Sequence; bcl-2-Associated X Protein; bcl-X Protein; Breast Neoplasms; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Paclitaxel; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 1996 |
The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro.
Topics: Acridines; Amsacrine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Line; Cell Survival; Daunorubicin; Drug Resistance, Multiple; HL-60 Cells; Humans; Idarubicin; Leukemia; Paclitaxel; Phenotype; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Verapamil | 1997 |
Multidrug resistance in androgen-independent growing rat prostate carcinoma cells is mediated by P-glycoprotein.
Topics: Androgens; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Fluorescent Dyes; Genes, MDR; Male; Methotrexate; Neoplasms, Hormone-Dependent; Paclitaxel; Prostatic Neoplasms; Rats; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine | 1997 |
BAX expression is associated with enhanced intracellular accumulation of paclitaxel: a novel role for BAX during chemotherapy-induced cell death.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; ATP-Binding Cassette Transporters; bcl-2-Associated X Protein; Female; Humans; Multidrug Resistance-Associated Proteins; Paclitaxel; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transfection; Tumor Cells, Cultured; Verapamil; Vinblastine | 1998 |
Effects of cytoskeletal inhibitors on the accumulation of vincristine in a resistant human lung cancer cell line with high level of polymerized tubulin.
Topics: Adenocarcinoma; Cell Survival; Colchicine; Cyclosporine; Cytochalasin B; Cytochalasin D; Cytoskeleton; Drug Resistance, Neoplasm; Drug Synergism; Humans; Lung Neoplasms; Neoplasm Proteins; Paclitaxel; Tubulin; Tumor Cells, Cultured; Verapamil; Vincristine | 1998 |
Paclitaxel shows cytotoxic activity in human hepatocellular carcinoma cell lines.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Drug Synergism; Flow Cytometry; Humans; Immunohistochemistry; Kidney Tubules; Liver Neoplasms; Male; Paclitaxel; Thymidine; Tumor Cells, Cultured; Verapamil | 1999 |
Reversal of P-glycoprotein-mediated multidrug resistance in vitro by AV200, a new ardeemin derivative.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Heterocyclic Compounds, 3-Ring; Humans; Paclitaxel; Rhodamine 123; Tumor Cells, Cultured; Verapamil; Vincristine | 1998 |
Isolation of a taxol-resistant Leishmania donovani promastigote mutant that exhibits a multidrug-resistant phenotype.
Topics: Animals; Antiprotozoal Agents; Calcium Channel Blockers; Doxorubicin; Drug Resistance, Multiple; Leishmania donovani; Mutation; Paclitaxel; Phenotype; Tubulin; Verapamil | 1999 |
ATP controls neuronal apoptosis triggered by microtubule breakdown or potassium deprivation.
Topics: Adenosine Triphosphate; Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Carrier Proteins; Caspase 3; Caspase Inhibitors; Caspases; Cerebellum; Colchicine; Cyclosporine; Cysteine Proteinase Inhibitors; Deoxyglucose; Dizocilpine Maleate; Energy Metabolism; Enzyme Activation; Enzyme Inhibitors; Glutathione; Mice; Mice, Inbred BALB C; Microfilament Proteins; Microtubules; Neurons; Neuroprotective Agents; Nitroso Compounds; Nocodazole; Oligopeptides; Paclitaxel; Potassium; Protein Biosynthesis; S-Nitrosoglutathione; Tacrolimus; Verapamil | 1999 |
Discovery of differentially expressed genes associated with paclitaxel resistance using cDNA array technology: analysis of interleukin (IL) 6, IL-8, and monocyte chemotactic protein 1 in the paclitaxel-resistant phenotype.
Topics: Breast Neoplasms; Chemokine CCL2; DNA, Complementary; Doxorubicin; Drug Resistance, Multiple; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Interleukin-8; Ovarian Neoplasms; Paclitaxel; Phenotype; Tumor Cells, Cultured; Verapamil; Vincristine | 1999 |
MDR3 P-glycoprotein, a phosphatidylcholine translocase, transports several cytotoxic drugs and directly interacts with drugs as judged by interference with nucleotide trapping.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Cell Polarity; Cells, Cultured; Cyclosporine; Cyclosporins; Cytotoxins; Daunorubicin; Digoxin; Epithelial Cells; Humans; Ivermectin; Kidney; Paclitaxel; Pharmaceutical Preparations; Phosphatidylcholines; Recombinant Proteins; Spodoptera; Swine; Verapamil; Vinblastine | 2000 |
Altered activity of MDR-reversing agents on KB3-1 cells transfected with Gly(185)-->Val human P-glycoprotein.
Topics: Adenosine Triphosphatases; Amino Acid Substitution; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Calcium Channel Blockers; Carcinoma, Squamous Cell; Colchicine; Cyclosporine; Cyclosporins; Daunorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Paclitaxel; Point Mutation; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured; Verapamil; Vinblastine | 2000 |
Investigating the platelet-sparing mechanism of paclitaxel/carboplatin combination chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Platelets; Carboplatin; Cell Division; Cells, Cultured; Colony-Forming Units Assay; Cytokines; Flow Cytometry; Glutathione Transferase; Growth Substances; Hematopoietic Stem Cells; Humans; Megakaryocytes; Myeloid Progenitor Cells; Neoplasms; Paclitaxel; RNA, Messenger; Stromal Cells; Thrombopoietin; Verapamil | 2001 |
A flow cell assay for evaluation of whole cell drug efflux kinetics: analysis of paclitaxel efflux in CCRF-CEM leukemia cells overexpressing P-glycoprotein.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Diffusion; Drug Resistance, Multiple; Flow Cytometry; Humans; Kinetics; Leukemia, Myeloid; Paclitaxel; Temperature; Tumor Cells, Cultured; Verapamil | 2001 |
Effect of P-glycoprotein on flavopiridol sensitivity.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; CHO Cells; Cisplatin; Colchicine; Colony-Forming Units Assay; Cricetinae; Drug Resistance, Multiple; Flavonoids; Paclitaxel; Piperidines; Quinidine; Verapamil | 2001 |
Mechanisms of taxotere-related drug resistance in pancreatic carcinoma.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Docetaxel; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Dyes; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Paclitaxel; Pancreatic Neoplasms; Rhodamine 123; RNA, Messenger; Taxoids; Tubulin; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Verapamil | 2001 |
Subcellular distribution of epothilones in human tumor cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Division; Cell Line; Epothilones; Epoxy Compounds; Humans; Kinetics; Macrolides; Paclitaxel; Thiazoles; Tumor Cells, Cultured; Verapamil | 2001 |
Abundant expression of the microtubule-associated protein, ensconsin (E-MAP-115), alters the cellular response to Taxol.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Chlorocebus aethiops; Drug Screening Assays, Antitumor; Drug Synergism; Epithelial Cells; Green Fluorescent Proteins; HeLa Cells; Humans; Kidney; Luminescent Proteins; Mice; Microtubule-Associated Proteins; Microtubules; Oxazoles; Paclitaxel; Protein Binding; Rats; Recombinant Fusion Proteins; Species Specificity; Tumor Cells, Cultured; Verapamil; Vinblastine | 2001 |
The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel.
Topics: Analgesics, Opioid; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buthionine Sulfoximine; Caco-2 Cells; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Genistein; Glutathione; Humans; Indomethacin; Morphine; Paclitaxel; Probenecid; Progesterone; Time Factors; Verapamil | 2002 |
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line; Digoxin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Gene Expression; Humans; Nifedipine; Paclitaxel; RNA, Messenger; Swine; Tritium; Tumor Cells, Cultured; Verapamil; Vinblastine | 2002 |
Enhanced oral bioavailability of paclitaxel by coadministration of the P-glycoprotein inhibitor KR30031.
Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Dose-Response Relationship, Drug; Drug Combinations; Humans; Male; Paclitaxel; Rats; Rats, Sprague-Dawley; Verapamil | 2003 |
Effects of carvedilol on MDR1-mediated multidrug resistance: comparison with verapamil.
Topics: Adrenergic beta-Antagonists; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Carbazoles; Carvedilol; Cell Division; Cell Line; Daunorubicin; Digoxin; DNA, Complementary; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epithelial Cells; Fluorouracil; HeLa Cells; Humans; Inhibitory Concentration 50; Kidney; Paclitaxel; Propanolamines; Swine; Transfection; Verapamil; Vinblastine | 2003 |
Novel oral formulation of paclitaxel inhibits neointimal hyperplasia in a rat carotid artery injury model.
Topics: Administration, Oral; alpha-Tocopherol; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Carotid Artery Injuries; Carotid Stenosis; Catheterization; Cell Division; Ethylene Glycols; Glycerol; Hyperplasia; Infusions, Parenteral; Intestines; Linoleic Acids; Male; Models, Animal; Myocytes, Smooth Muscle; Paclitaxel; Pharmaceutical Vehicles; Polysorbates; Radiography; Rats; Rats, Sprague-Dawley; Recurrence; Surface-Active Agents; Tocopherols; Tunica Intima; Verapamil | 2004 |
Induction of a multifactorial resistance phenotype by high paclitaxel selective pressure in a human ovarian carcinoma cell line.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluorouracil; Humans; Inhibitory Concentration 50; Methotrexate; Mitochondrial Proteins; Multidrug Resistance-Associated Proteins; Ovarian Neoplasms; Paclitaxel; Phenotype; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Tetrazolium Salts; Time Factors; Tubulin; Verapamil; Vinblastine | 2004 |
Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Separation; Culture Media, Conditioned; Cytokines; Disease Progression; DNA, Complementary; Dose-Response Relationship, Drug; Down-Regulation; Doxorubicin; Drug Resistance, Multiple; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Immunoprecipitation; Lung Neoplasms; Mesothelioma; Paclitaxel; Phenotype; Plasmids; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-kit; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Snail Family Transcription Factors; Stem Cell Factor; Transcription Factors; Transfection; Up-Regulation; Verapamil; Vincristine | 2004 |
Multidrug transporter activity in lymphocytes.
Topics: Adrenergic alpha-Antagonists; Aniline Compounds; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; B-Lymphocytes; Calcium Channel Blockers; Fluoresceins; Fluorescent Dyes; Lymphocytes; Mice; Mice, Knockout; Mitoxantrone; Multidrug Resistance-Associated Proteins; Paclitaxel; Prazosin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Verapamil; Xanthenes | 2004 |
The effect of verapamil on the pharmacokinetics of paclitaxel in rats.
Topics: Animals; Drug Interactions; Male; Paclitaxel; Rats; Rats, Sprague-Dawley; Verapamil | 2005 |
Taxoids and abietanes from callus cultures of Taxus cuspidata.
Topics: Abietanes; Culture Techniques; Drug Screening Assays, Antitumor; Molecular Structure; Paclitaxel; Plants, Medicinal; Taxoids; Taxus; Tumor Cells, Cultured; Verapamil | 2005 |
Transport and cytotoxicity of paclitaxel, docetaxel, and novel taxanes in human breast cancer cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Inhibitory Concentration 50; Membrane Transport Proteins; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Paclitaxel; RNA, Messenger; Taxoids; Time Factors; Verapamil | 2005 |
Co-treatment with grapefruit juice inhibits while chronic administration activates intestinal P-glycoprotein-mediated drug efflux.
Topics: Algorithms; Animals; Antineoplastic Agents, Phytogenic; Antitubercular Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Citrus paradisi; Dose-Response Relationship, Drug; Food-Drug Interactions; HIV Protease Inhibitors; Ileum; In Vitro Techniques; Indinavir; Intestinal Absorption; Male; Paclitaxel; Permeability; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Rifampin; Verapamil | 2005 |
Paclitaxel-resistant cells have a mutation in the paclitaxel-binding region of beta-tubulin (Asp26Glu) and less stable microtubules.
Topics: Amino Acid Substitution; Animals; Antineoplastic Agents, Phytogenic; Aspartic Acid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Squamous Cell; Cell Line, Tumor; Docetaxel; Drug Resistance, Neoplasm; Epothilones; Glutamic Acid; Humans; Mice; Mice, Nude; Microtubules; Paclitaxel; Point Mutation; Protein Conformation; Taxoids; Tubulin; Verapamil | 2006 |
Induced resistance in the human non small cell lung carcinoma (NCI-H460) cell line in vitro by anticancer drugs.
Topics: Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Curcumin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Glutathione Transferase; Humans; Lung Neoplasms; Multidrug Resistance-Associated Proteins; Paclitaxel; Rhodamines; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Verapamil; Vinblastine | 2006 |
Susceptibility of nanoparticle-encapsulated paclitaxel to P-glycoprotein-mediated drug efflux.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Lactic Acid; Nanoparticles; Paclitaxel; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Solubility; Time Factors; Verapamil | 2006 |
The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated efflux.
Topics: Algorithms; Antineoplastic Agents, Phytogenic; Antiparasitic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Products; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Drug Interactions; Flavonoids; Humans; Paclitaxel; Phenols; Plants; Verapamil | 2006 |
Oxycodone induces overexpression of P-glycoprotein (ABCB1) and affects paclitaxel's tissue distribution in Sprague Dawley rats.
Topics: Adenosine Triphosphatases; Analgesics, Opioid; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Drug Interactions; Drug Tolerance; Humans; Male; Mice; Mice, Knockout; Oxycodone; Paclitaxel; Pain Measurement; Rats; Rats, Sprague-Dawley; Spectrophotometry, Ultraviolet; Tissue Distribution; Up-Regulation; Verapamil | 2007 |
Reversal of multidrug resistance by methoxypolyethylene glycol-block-polycaprolactone diblock copolymers through the inhibition of P-glycoprotein function.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cell Membrane Permeability; Cell Proliferation; Cell Survival; Dogs; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Gene Expression Regulation; Humans; Paclitaxel; Polyesters; Polyethylene Glycols; Verapamil | 2009 |
Inhibition of P-glycoprotein-mediated paclitaxel resistance by reversibly linked quinine homodimers.
Topics: Adenocarcinoma; Adenosine Triphosphatases; Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Dimerization; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Molecular Structure; Paclitaxel; Prazosin; Quinine; Rhodamine 123; Verapamil | 2009 |
Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2.
Topics: Doxorubicin; Drug Resistance, Neoplasm; Hep G2 Cells; Humans; Liver; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Organic Anion Transporters, Sodium-Independent; Paclitaxel; Probenecid; Rhodamine 123; RNA, Messenger; Sodium Azide; Solute Carrier Organic Anion Transporter Family Member 1B3; Sulfobromophthalein; Verapamil | 2009 |
Syl611, a novel semisynthetic taxane derivative, reverses multidrug resistance by p-glycoprotein inhibition and facilitating inward transmembrane action.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; KB Cells; Paclitaxel; Permeability; Rhodamine 123; Taxoids; Verapamil | 2010 |
In vitro cytotoxic activity of cationic paclitaxel nanoparticles on MDR-3T3 cells.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cations; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Mice; Microscopy, Electron, Transmission; Nanoparticles; NIH 3T3 Cells; Paclitaxel; Particle Size; Solubility; Surface Properties; Verapamil | 2010 |
Multidrug resistance reversal agent, NSC77037, identified with a cell-based screening assay.
Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzylisoquinolines; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fluoresceins; Humans; Paclitaxel; Substrate Specificity; Time Factors; Verapamil | 2010 |
Effect of Thai plant extracts on P-glycoprotein function and viability in paclitaxel-resistant HepG2 cells.
Topics: Annonaceae; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Drug Resistance, Neoplasm; Drug Synergism; Hep G2 Cells; Herbal Medicine; Humans; Multidrug Resistance-Associated Proteins; Paclitaxel; Phytotherapy; Plant Extracts; Rhodamine 123; Rutaceae; Thailand; Tumor Cells, Cultured; Verapamil | 2010 |
CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; CDX2 Transcription Factor; Colon; Colonic Neoplasms; Drug Resistance, Neoplasm; Gene Expression Regulation, Neoplastic; Homeodomain Proteins; HT29 Cells; Humans; Paclitaxel; Verapamil; Vincristine | 2010 |
The mechanism of enhancement on oral absorption of paclitaxel by N-octyl-O-sulfate chitosan micelles.
Topics: Absorption; Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biocompatible Materials; Biological Availability; Caco-2 Cells; Calcium Channel Blockers; Chitosan; Endocytosis; Humans; Materials Testing; Micelles; Paclitaxel; Rats; Rats, Sprague-Dawley; Verapamil | 2011 |
Synergistic effect of folate-mediated targeting and verapamil-mediated P-gp inhibition with paclitaxel -polymer micelles to overcome multi-drug resistance.
Topics: Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Chitosan; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Flow Cytometry; Fluorescence; Folic Acid; Humans; Inhibitory Concentration 50; Micelles; Microscopy, Electron, Scanning; Paclitaxel; Particle Size; Polymers; Verapamil; X-Ray Diffraction | 2011 |
Up-regulation of P-glycoprotein is involved in the increased paclitaxel resistance in human esophageal cancer radioresistant cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cisplatin; Colony-Forming Units Assay; Drug Resistance; Esophageal Neoplasms; Gene Expression; Humans; Neoplasms, Radiation-Induced; Paclitaxel; Radiation Tolerance; RNA, Messenger; Up-Regulation; Verapamil | 2012 |
BBA, a derivative of 23-hydroxybetulinic acid, potently reverses ABCB1-mediated drug resistance in vitro and in vivo.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Breast Neoplasms; Calcium Channel Blockers; Camptothecin; Carcinoma, Hepatocellular; Cell Proliferation; Cells, Cultured; Cisplatin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorescent Antibody Technique; Humans; In Vitro Techniques; Irinotecan; KB Cells; Liver Neoplasms; Male; Mice; Mice, Nude; Models, Molecular; Molecular Docking Simulation; Paclitaxel; Piperidines; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Triterpenes; Verapamil | 2012 |
Integrating constitutive gene expression and chemoactivity: mining the NCI60 anticancer screen.
Topics: Algorithms; Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cluster Analysis; Colchicine; Computational Biology; Cyclin-Dependent Kinases; Dasatinib; Databases, Genetic; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Neoplasms; Oligonucleotide Array Sequence Analysis; Paclitaxel; Pimozide; Purines; Pyrimidines; Terfenadine; Thiazoles; Tubulin Modulators; Verapamil | 2012 |
2-Hydroxypropyl-β-cyclodextrin-modified SLN of paclitaxel for overcoming p-glycoprotein function in multidrug-resistant breast cancer cells.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta-Cyclodextrins; Biological Transport; Breast Neoplasms; Calcium Channel Blockers; Cell Survival; Chemistry, Pharmaceutical; Drug Delivery Systems; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Excipients; Female; Humans; MCF-7 Cells; Nanoparticles; Neoplasm Proteins; Paclitaxel; Stearic Acids; Surface-Active Agents; Ultrasonics; Verapamil | 2013 |
ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Membrane; Drug Resistance, Multiple; Humans; Molecular Sequence Data; Nucleotides; Paclitaxel; Recombinant Proteins; Verapamil; Vinblastine | 2013 |
Key structure of brij for overcoming multidrug resistance in cancer.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line, Tumor; Cell Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Hydrophobic and Hydrophilic Interactions; Lung Neoplasms; Nanoparticles; Paclitaxel; Plant Oils; Polidocanol; Polyethylene Glycols; Surface-Active Agents; Verapamil | 2013 |
Bipiperidinyl derivatives of 23-hydroxybetulinic acid reverse resistance of HepG2/ADM and MCF-7/ADR cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; MCF-7 Cells; Molecular Docking Simulation; Paclitaxel; Piperidines; Rhodamine 123; Triterpenes; Verapamil; Vincristine | 2013 |
[In situ rat intestine absorption of paclitaxel-loaded solid lipid nanoparticles modified with cell-penetrating peptides].
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell-Penetrating Peptides; Drug Carriers; Intestinal Absorption; Lipids; Male; Nanoparticles; Oligopeptides; Paclitaxel; Perfusion; Rats; Rats, Sprague-Dawley; Stearic Acids; Verapamil | 2013 |
ABCB1-overexpressing MG63/DOX cell xenograft model: maintain the MDR phenotype in vivo.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Neoplasms; Cell Line, Tumor; Cytarabine; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Osteosarcoma; Paclitaxel; Verapamil; Xenograft Model Antitumor Assays | 2013 |
Pluronic-poly (acrylic acid)-cysteine/Pluronic L121 mixed micelles improve the oral bioavailability of paclitaxel.
Topics: Acrylic Resins; Administration, Oral; Animals; Area Under Curve; Biological Availability; Cysteine; Drug Carriers; Intestinal Absorption; Male; Micelles; Paclitaxel; Particle Size; Poloxamer; Rats; Rats, Wistar; Verapamil | 2014 |
Enhanced oral bioavailability of paclitaxel by concomitant use of absorption enhancers and P-glycoprotein inhibitors in rats.
Topics: Absorption; Administration, Oral; Animals; Antineoplastic Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; Biological Availability; Cyclosporine; Ibuprofen; Male; Paclitaxel; Permeability; Rats; Rats, Sprague-Dawley; Solubility; Verapamil | 2013 |
Circumvention of inherent or acquired cytotoxic drug resistance in vitro using combinations of modulating agents.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cinnarizine; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Inhibitory Concentration 50; Maximum Tolerated Dose; MCF-7 Cells; Mice; Paclitaxel; Quinine; Verapamil; Vincristine | 2013 |
Effects of lipid vehicle and P-glycoprotein inhibition on the mesenteric lymphatic transport of paclitaxel in unconscious, lymph duct-cannulated rats.
Topics: Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Catheterization; Excipients; Intestinal Mucosa; Linoleic Acid; Lipids; Lymphatic System; Male; Mesentery; Paclitaxel; Rats; Rats, Sprague-Dawley; Verapamil | 2016 |
Water-soluble and cleavable quercetin-amino acid conjugates as safe modulators for P-glycoprotein-based multidrug resistance.
Topics: Alanine; Amino Acids; Antineoplastic Agents; Antioxidants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Line, Tumor; Cell Survival; Dactinomycin; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Glutamic Acid; Humans; Microscopy, Confocal; Models, Chemical; Molecular Structure; Paclitaxel; Quercetin; Verapamil; Vinblastine | 2014 |
Inhibition of multidrug transporter in tumor endothelial cells enhances antiangiogenic effects of low-dose metronomic paclitaxel.
Topics: Administration, Metronomic; Animals; Anti-Arrhythmia Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Drug Resistance, Neoplasm; Endothelial Cells; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Paclitaxel; Verapamil; Xenograft Model Antitumor Assays | 2015 |
Controlled release and reversal of multidrug resistance by co-encapsulation of paclitaxel and verapamil in solid lipid nanoparticles.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; beta-Cyclodextrins; Biological Transport; Cell Line, Tumor; Cell Survival; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Nanoparticles; Paclitaxel; Poloxamer; Poly(ADP-ribose) Polymerases; Verapamil | 2015 |
[Effect of Radix euphorbiae pekinensis extract on bioavailability of paclitaxel after their oral co-administration].
Topics: Administration, Oral; Animals; Biological Availability; Biological Transport; Chromatography, High Pressure Liquid; Euphorbiaceae; Paclitaxel; Permeability; Plant Extracts; Plant Roots; Rats; Tandem Mass Spectrometry; Verapamil | 2015 |
ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells.
Topics: Acridines; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Blotting, Western; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Gene Knockdown Techniques; Humans; Immunohistochemistry; Ovarian Neoplasms; Paclitaxel; Phthalazines; Piperazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrahydroisoquinolines; Verapamil | 2016 |
Direct in vivo evidence on the mechanism by which nanoparticles facilitate the absorption of a water insoluble, P-gp substrate.
Topics: Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line, Tumor; Chitosan; Drug Carriers; Epithelial Cells; Humans; Ileum; Intestinal Absorption; Male; Mice; Nanoparticles; Paclitaxel; Rats; Rats, Wistar; Solubility; Tight Junctions; Verapamil; Water | 2016 |
Evidence That P-glycoprotein Inhibitor (Elacridar)-Loaded Nanocarriers Improve Epidermal Targeting of an Anticancer Drug via Absorptive Cutaneous Transporters Inhibition.
Topics: Acridines; Administration, Cutaneous; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Drug Carriers; Emulsions; Membrane Transport Proteins; Mice; Mice, Inbred BALB C; Nanoparticles; Paclitaxel; Particle Size; Skin; Tetrahydroisoquinolines; Verapamil | 2018 |
N-mercapto acetyl-N'-octyl-O, N″-glycol chitosan as an efficiency oral delivery system of paclitaxel.
Topics: Administration, Oral; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Caco-2 Cells; Chitosan; Drug Carriers; Endocytosis; Humans; Intestinal Mucosa; Micelles; Paclitaxel; Particle Size; Rats, Sprague-Dawley; Tight Junctions; Verapamil | 2018 |
Taxol Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and the Multidrug Resistance Associated P-Glycoprotein.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Humans; Microtubules; Ovarian Neoplasms; Paclitaxel; Taxoids; Tubulin; Tumor Cells, Cultured; Verapamil; Vinblastine | 2018 |
Enhanced anticancer activity and intracellular uptake of paclitaxel-containing solid lipid nanoparticles in multidrug-resistant breast cancer cells.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Death; Cell Line, Tumor; Chlorpromazine; Dogs; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endocytosis; Female; Humans; Inhibitory Concentration 50; Lipids; Madin Darby Canine Kidney Cells; Nanoparticles; Paclitaxel; Particle Size; Verapamil | 2018 |
Preparation and evaluation of carboxymethyl chitosan-rhein polymeric micelles with synergistic antitumor effect for oral delivery of paclitaxel.
Topics: Administration, Oral; Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Chitosan; Drug Carriers; Drug Liberation; Drug Synergism; Humans; Male; Mice, Inbred ICR; Micelles; Neoplasms; Paclitaxel; Verapamil | 2019 |
Self-assembled micelles based on N-octyl-N'-phthalyl-O-phosphoryl chitosan derivative as an effective oral carrier of paclitaxel.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Chitosan; Down-Regulation; Drug Carriers; Drug Liberation; Endocytosis; Humans; Intestinal Absorption; Intestinal Mucosa; Male; Membrane Fluidity; Mice, Inbred BALB C; Micelles; Paclitaxel; Rats, Sprague-Dawley; Solubility; Transcytosis; Verapamil | 2019 |
Evidence for the Interaction of A
Topics: Adenosine A3 Receptor Agonists; ATP Binding Cassette Transporter, Subfamily B; Azides; Binding Sites; HeLa Cells; Humans; Models, Molecular; Molecular Docking Simulation; Paclitaxel; Prazosin; Structure-Activity Relationship; Verapamil | 2019 |
Synergistic effect of paclitaxel and verapamil to overcome multi-drug resistance in breast cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Female; Humans; MCF-7 Cells; Paclitaxel; Vasodilator Agents; Verapamil | 2019 |
Evaluation of intestinal permeation enhancement with carboxymethyl chitosan-rhein polymeric micelles for oral delivery of paclitaxel.
Topics: Administration, Oral; Animals; Anthraquinones; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B; Caco-2 Cells; Chitosan; Disease Models, Animal; Drug Carriers; Drug Compounding; Humans; Intestinal Mucosa; Male; Mice; Micelles; Neoplasms; Paclitaxel; Permeability; Rats; Tissue Distribution; Verapamil | 2020 |
Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells.
Topics: Adenosine Triphosphatases; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Models, Molecular; Molecular Docking Simulation; Paclitaxel; Protein Kinase Inhibitors; Purines; TOR Serine-Threonine Kinases; Verapamil | 2020 |
P-Glycoprotein Inhibition Exacerbates Paclitaxel Neurotoxicity in Neurons and Patients With Cancer.
Topics: Antineoplastic Agents, Phytogenic; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cyclosporins; Dose-Response Relationship, Drug; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Neurons; Paclitaxel; Peripheral Nervous System Diseases; Retrospective Studies; Risk Assessment; Risk Factors; Simvastatin; Verapamil | 2020 |
Metabolomics analysis of multidrug resistance in colorectal cancer cell and multidrug resistance reversal effect of verapamil.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biomarkers; Cell Line, Tumor; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Metabolome; Metabolomics; Paclitaxel; Tandem Mass Spectrometry; Verapamil | 2021 |
Dietary bioactive diindolylmethane enhances the therapeutic efficacy of centchroman in breast cancer cells by regulating ABCB1/P-gp efflux transporter.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Binding Sites; Biological Transport; Cell Line, Tumor; Centchroman; Estrogen Antagonists; Gene Expression Regulation; Humans; Indoles; Multidrug Resistance-Associated Proteins; Paclitaxel; Protein Binding; Verapamil | 2021 |
Bioactivity inspired C
Topics: Alkaloids; Diterpenes; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasms; Paclitaxel; Verapamil; Vincristine | 2022 |
Design, synthesis and biological evaluation of seco-DSP/DCK derivatives reversing P-glycoprotein-mediated paclitaxel resistance in A2780/T cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Female; Humans; Ovarian Neoplasms; Paclitaxel; T-Lymphocytes; Verapamil | 2023 |
A new taxoid from a callus culture of Taxus cuspidata as an MDR reversal agent.
Topics: Antineoplastic Agents, Phytogenic; Calcium Channel Blockers; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Fluoresceins; Humans; Taxoids; Taxus; Verapamil | 2006 |
Four new minor taxanes from cell cultures of Taxus chinensis.
Topics: Antineoplastic Agents, Phytogenic; Cell Culture Techniques; Drug Resistance, Multiple; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Stereoisomerism; Taxoids; Taxus; Verapamil | 2009 |
Synthesis and structure-activity relationships of sinenxan A derivatives as multidrug resistance reversal agents.
Topics: Acetates; Calcium Channel Blockers; Diterpenes; Drug Resistance, Multiple; Humans; Neoplasms; Structure-Activity Relationship; Taxus; Tumor Cells, Cultured; Verapamil | 2010 |