verapamil has been researched along with norverapamil in 163 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (33.74) | 18.7374 |
| 1990's | 55 (33.74) | 18.2507 |
| 2000's | 34 (20.86) | 29.6817 |
| 2010's | 18 (11.04) | 24.3611 |
| 2020's | 1 (0.61) | 2.80 |
| Authors | Studies |
|---|---|
| Burk, O; Eichelbaum, M; Fromm, MF; Mettang, T; Pauli-Magnus, C; von Richter, O; Ziegler, A | 1 |
| Pajeva, IK; Wiese, M | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Chibale, K; Kumar, M; Naran, K; Pavadai, E; Ruminski, PG; Singh, K; Warner, DF | 1 |
| Czubryt, MP; Docherty, JC; Dubo, DF; Gilchrist, JS; Lonsberry, BB; Maddaford, TG; Pierce, GN | 1 |
| Frick, MH; Heikkilä, J; Lukkala, K; Pellinen, TJ; Sundberg, S | 1 |
| Brode, E; Kern, R; Schöbel, D | 1 |
| Czejka, MJ; Podesser, B; Zwoelfer, N | 1 |
| Echizen, H; Eichelbaum, M; Heidemann, H; Kroemer, HK | 1 |
| Shibukawa, A; Wainer, IW | 1 |
| Blaschke, G; Fieger, H | 1 |
| Blume, H; Harder, S; Huber, T; Rietbrock, N; Siewert, M; Thürmann, P | 1 |
| Balderston, SM; Johnson, KE; Mann, DE; Pieper, JA; Reiter, MJ | 1 |
| Ermakovich, II; Kobzar', AI; Menzianova, NG | 1 |
| Köppel, C; Wagemann, A | 1 |
| Devane, J; Martin, M; Mulligan, S | 1 |
| Ahmed, JH; Elliott, HL; Meredith, PA | 1 |
| Frantz, RP; Kurtz, SB; McCarthy, JT; Moyer, TP; Smith, RL; Theobald, HM; Zachariah, PK | 1 |
| Benz, B; Eichelbaum, M; Gekeler, V; Häussermann, K; Schumacher, K | 1 |
| Bonaduce, D; Canonico, V; De Caprio, L; Forgione, L; Nicolino, A; Petretta, M; Rengo, F | 1 |
| Arrendale, RF; Martin, RM; Stewart, JT | 1 |
| Mutlib, AE; Nelson, WL | 1 |
| Husum, D; Jensen, G; Johnsen, A | 1 |
| Conway, EL; Drummer, OH; Louis, WJ; Phillips, PA | 1 |
| Koch, RL; Palicharla, P | 1 |
| Battle, MM; Colburn, WA; Eldon, MA; Voigtman, RE | 1 |
| Chu, YQ; Wainer, IW | 1 |
| Czogalla, W; Dilger, C; Jaeger, H; Otto, R; Salama, ZB | 1 |
| Flanigan, P; Freshney, RI; Kaye, SB; Merry, S; Schlick, E | 1 |
| Hansen, JF; Jespersen, CM; Klitgaard, NA; Nielsen, H | 1 |
| Bailey, DG; Carruthers, SG; Freeman, DJ | 1 |
| Chan, LT; Chhuy, LH; Crowley, RJ | 1 |
| Kannikoski, A; Marvola, M; Ottoila, P; Taskinen, J | 1 |
| Anderson, P | 1 |
| Kremer Hovinga, TK; ter Wee, PM; Uges, DR; van der Geest, S | 1 |
| Feldman, RD; Lai, CY; Park, GD | 1 |
| Gordin, A; Jounela, AJ; Ottoila, P; Salmela, PI; Salo, H | 1 |
| Arends, BG; Petri, H; van Baak, MA | 1 |
| Cockayne, D; Hill, GW; Muirhead, DC; Norris, RJ | 1 |
| Blumhardt, CL; Doran, AR; Narang, PK; Pickar, D | 1 |
| Jørgensen, NP; Walstad, RA | 1 |
| Anderson, P; Bondesson, U; Boréus, LO; Hynning, PA | 1 |
| Chow, MS; Hanyok, JJ; Izard, MW; Kluger, J | 1 |
| Lennard, MS; McCourty, JC; Silas, JH; Tucker, GT | 1 |
| Elliott, SL; Horowitz, JD; Powell, AC | 1 |
| Hals, O; Lauve, O; Midtbø, K; Storstein, L; van der Meer, J | 1 |
| Bühler, FR; Follath, F; Ha, HR; Hotz, H; Müller, FB; Schmidlin, O | 1 |
| Hals, O; Lauve, O; Midtbo, KA | 1 |
| Breier, A; Doran, AR; Labarca, R; Narang, PK; Pickar, D; Roy, A; Wolkowitz, OM | 1 |
| Bredehoeft, SJ; Chaturvedi, AK; Hidding, JT; Rao, NG; Smith, JC | 1 |
| Horne, C; Knauf, H; Mutschler, E; Spahn, H | 1 |
| Bhamra, R; Holt, DW; Miller, MR; Withers, R | 1 |
| Abernethy, DR; Mitchell, JR; Schwartz, JB; Todd, E | 1 |
| Abernethy, DR; Todd, EL | 1 |
| Piotrovskiĭ, VK; Riabokon', OS; Rumiantsev, DO; Slastnikova, ID; Vygodin, VA | 1 |
| Crompton, C; Crouch, DJ; Francom, P; Peat, MA; Rollins, DE | 1 |
| Anderson, P; Bondesson, U; de Faire, U | 1 |
| Anderson, P; Bondesson, U; Johansson, BW; Mattiasson, I | 1 |
| Metelitsa, VI; Nikolenko, SA; Piotrovskii, VK; Riabokon, OS; Rumiantsev, DO | 1 |
| Kapur, PA; Law, T; Watson, E | 1 |
| Bury, RW; Fullinfaw, RO; Kacprowicz, AT | 1 |
| Abernethy, DR; Mitchell, JR; Schwartz, JB; Taylor, AA | 1 |
| Barbieri, E; Cargnelli, G; Ferrari, M; Padrini, R; Piovan, D; Toffoli, M; Trevi, G | 1 |
| Mooy, J; Muytjens, A; Rahn, KH; Schols, M; v Baak, M; v Hooff, M | 1 |
| Shah, GM; Winer, RL | 1 |
| Barbieri, E; Ferrari, M; Motta, A; Padrini, R; Piovan, D; Toffoli, M; Trevi, GP | 1 |
| Abernethy, DR; Mitchell, JR; Todd, EL | 1 |
| Cubeddu, LX; Gross, KM; Halperin, AK; Rogers, JF | 1 |
| Larsen, A; Midtbø, K; Saevareid, L; Storstein, L | 1 |
| Hamann, SR; McAllister, RG; Todd, GD | 1 |
| Frishman, W; Hillis, LD; Johnson, SM; Kates, R; Kirsten, E; Klein, M; Packer, M; Pine, M | 1 |
| Lopez, LL; Mehta, J; Pieper, JA; Tartaglione, TA | 1 |
| Guerrero, J; Hecht, HS; Hopkins, J; Josephson, MA; Singh, BN | 1 |
| Anticoli, M; Ellul, D; Rocchini, AP; Vasiliades, J; Wilkerson, K | 1 |
| Harrison, DC; Kates, RE; Keefe, DL; Kirsten, E; Schwartz, JB | 1 |
| Aanonsen, LM; McCarthy, E; Pritchett, EL; Reiter, MJ; Shand, DG; Wagoner, R | 1 |
| Aanonsen, L; Hammill, SC; Pritchett, EL; Shand, DG | 1 |
| Cole, SC; Flanagan, RJ; Holt, DW; Johnston, A | 1 |
| Harapat, SR; Kates, RE | 1 |
| Bates, TR; Kunka, RL; Yong, CL | 1 |
| Mehvar, R; Reynolds, J | 1 |
| Cordon-Cardo, C; Fischer, P; Lianes, P; Lyn, P; Motzer, RJ; Ngo, RL; O'Brien, JP | 1 |
| Balis, FM; Bates, SE; Bryant, G; Chabner, BA; Jamis-Dow, C; Klecker, RW; Kohler, DR; Steinberg, SM; Wilson, WH; Wittes, RE | 1 |
| Gillespie, WR; Stagni, G | 1 |
| Akers, WS; Johnson, JA | 1 |
| Brátová, M; Fendrich, Z; Hůlek, P; Macek, K; Vlcek, J | 1 |
| Ferrari, M; Magnolfi, G; Milanesi, O; Padrini, R; Pellegrino, PA; Piovan, D; Svalato Moreolo, G; Zordan, R | 1 |
| Morganroth, J; Waldman, SA | 1 |
| Longstreth, JA; Mehvar, R; Reynolds, JM; Robinson, MA | 1 |
| De Broux, S; Dethy, JM; Gilbert, P; Lesne, M; Longstreth, J | 1 |
| Fort, S; John, DN; Lewis, MJ; Luscombe, DK | 1 |
| Beaune, P; Eichelbaum, M; Gautier, JC; Henderson, C; Kroemer, HK; Wolf, CR | 1 |
| Abdel-Rahman, MS; Harder, S; Woodcock, BG; Wosch, F | 1 |
| Atkinson, L; Gupta, SK; Longstreth, JA; Tu, T | 1 |
| Bhatti, MM; Foster, RT; Lewanczuk, RZ; Pasutto, FM | 1 |
| Atkinson, L; Gupta, SK; Longstreth, J; Yih, BM | 1 |
| Liu, XQ; Tan, L; Yang, SR; Yuan, YS | 1 |
| Mehvar, R; Robinson, MA | 1 |
| Ceccato, A; Chiap, P; Crommen, J; Hubert, P; Toussaint, B | 1 |
| Amamoto, T; Handa, T; Hashiguchi, M; Hirashima, Y; Irie, S; Ishii, S; Kimura, R; Maeda, A; Mori, Y; Ogata, H; Otsuka, N; Urae, A; Urae, R | 1 |
| Kivistö, KT; Neuvonen, PJ; Tarssanen, L | 1 |
| Fried, K; Wainer, IW | 1 |
| Aramayona, JJ; Bregante, MA; Fraile, LJ; Garcia, MA; Solans, C | 2 |
| Erickson, KA; Giovanoni, RL; Netland, PA; Siegner, SW | 1 |
| Asafu-Adjaye, EB; Shiu, GK | 1 |
| Karlsson, A; Lennernäs, H; Sandström, R | 1 |
| Boiocchi, M; De Cicco, M; Fabiani, F; Fantin, D; Fracasso, A; Lestuzzi, C; Macor, F; Matovic, M; Nicolosi, G; Robieux, I; Santantonio, C; Toffoli, G; Zanette, G | 1 |
| Gonzalez, FJ; Korzekwa, KR; Tracy, TS; Wainer, IW | 1 |
| Busch, AE; Eichelbaum, M; Lang, F; Mörike, K; Niemeyer, G; Suessbrich, H; Wagner, CA; Waldegger, S | 1 |
| Lennernäs, H; Sandström, R | 1 |
| Barnas, CR; Gorski, JC; Krecic-Shepard, ME; Schwartz, JB; Slimko, J; Wainer, IW | 1 |
| Brandsteterová, E; Tracy, T; Wainer, IW | 1 |
| Karlsson, A; Lennernäs, H; Ohlén, K; Sandström, R | 1 |
| Sawicki, W | 2 |
| Hanada, K; Hashiguchi, M; Mori, T; Mori, Y; Ogata, H; Tsukahara, Y | 1 |
| Blaschke, G; Brandsteterová, E; Endresz, G | 1 |
| Janicki, S; Sawicki, W | 1 |
| An, D; Lin, S; Rui, J; Xiang, B; Yuan, Y; Zhou, X | 1 |
| Ackermann, BL; Delatour, C; Dethy, JM; Henion, JD; Schultz, GA | 1 |
| Artursson, P; Engman, H; Lennernäs, H; Tannergren, C | 1 |
| Borlak, J; Levsen, K; Thum, T; Walles, M | 1 |
| Borlak, J; Elend, M; Levsen, K; Preiss, A; Thum, T; Walles, M | 1 |
| Hall, SD; Jones, DR; Wang, YH | 1 |
| Bondesson, U; Fredriksson, E; Hedeland, M; Lennernäs, H | 1 |
| Choi, JS; Han, HK | 1 |
| Hoogmartens, J; Lou, Y; Thi Thanh Ha, P; Van Schepdael, A; Zhang, J | 1 |
| Burm, JP; Choi, JS | 2 |
| Choi, JS; Kim, HJ | 1 |
| Gilissen, RA; Ha, PT; Hoogmartens, J; Sluyts, I; Van Dyck, S; VanSchepdael, A; Zhang, J | 1 |
| Choi, JS; Yeum, CH | 1 |
| Boursier-Neyret, C; Carrupt, PA; Castella, ME; Delbos, JM; Mayer, JM; Reist, M; Testa, B; Turban, JJ; Walther, B | 1 |
| Dadashzadeh, S; Javadian, B; Sadeghian, S | 1 |
| Cai, Y; Jia, J; Li, S; Liu, G; Liu, Y; Pan, C; Ren, J; Yu, C | 1 |
| Ducharme, J; Gauvin, C; Morin, PE; Panetta, R; Walles, M | 1 |
| Dagenais, NJ; Dryden, WF; Hanafy, S; Jamali, F | 1 |
| Choi, DH; Choi, JS; Shin, WG | 1 |
| Kang, W; Liu, KH; Pan, W; Ryu, JY; Shin, JG; Shon, JH; Song, IS; Sunwoo, YE | 1 |
| Boralli, VB; Lanchote, VL; Lepera, JS; Marques, MP; Mateus, FH | 1 |
| Choi, JS; Piao, YJ | 1 |
| Choi, DH; Choi, JS; Chung, JH | 2 |
| Kleinschmidt, KC; Velez, LI; Young, AC | 1 |
| Borchardt, RT; Jin, JY; Mudra, DR | 1 |
| Chang, KS; Choi, DH; Choi, JS; Hong, SP; Koh, YY | 1 |
| Dahlke, M; Hariry, S; Jarugula, V; Leon, S; Rebello, S | 1 |
| Hu, N; Jing, XY; Liu, CH; Liu, XD; Wang, GJ; Xie, L; Xie, SS | 1 |
| Chen, G; Hu, N; Liu, H; Liu, L; Liu, X; Pan, X; Wang, G; Wang, X; Xie, L; Xie, S; Zhang, L | 1 |
| Kang, HE; Lee, MG; Lee, YS; Yoon, IS; Yoon, JN | 1 |
| Guttikar, S; Mills, M; Patel, D; Shrivastav, PS; Singhal, P; Winter, S; Yadav, M | 1 |
| Barter, Z; Jamei, M; Neuhoff, S; Rostami-Hodjegan, A; Turner, DB; Yeo, KR | 1 |
| Liu, L; Liu, X; Sai, Y; Wang, D; Wang, J; Xia, S; Xue, W | 1 |
| Benet, LZ; Estudante, M; Maya, M; Morais, JG; Soveral, G | 1 |
| Adams, KN; Ramakrishnan, L; Szumowski, JD | 1 |
| Chamnansua, M; Kaewdang, N; Lohitnavy, M; Methaneethorn, J | 1 |
| Chow, EC; Pang, KS; Si, L; Sveigaard, HH; Tang, H; Yang, QJ | 1 |
| Capela, JM; Cardoso, JL; de Moraes, NV; Lanchote, VL; Lepera, JS; Pereira, MP | 1 |
| Abate, G; Campbell, M; Chibale, K; Eickhoff, CS; Hamzabegovic, F; Hoft, DF; Kumar, M; Ruminiski, PG; Selimovic, A; Singh, K | 1 |
| Jiang, L; Li, Z; Qin, J; Shi, Y; Su, W; Tao, T; Xu, C; Zhu, Y | 1 |
| Chan, ECY; Cheong, EJY; Chua, DXY; Teo, DWX | 1 |
| Deng, B; Sun, S; Tang, L; Wang, H; Wei, Y | 1 |
3 review(s) available for verapamil and norverapamil
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
Pharmacokinetics of calcium channel blocking agents.
Topics: Administration, Oral; Angina Pectoris; Atrial Fibrillation; Biological Availability; Cardiomegaly; Clinical Trials as Topic; Female; Humans; Hypertension; Injections, Intravenous; Kinetics; Liver Cirrhosis; Male; Middle Aged; Nifedipine; Verapamil | 1986 |
Column-switching techniques in the biomedical analysis of stereoisomeric drugs: why, how and when.
Topics: Animals; Chromatography, High Pressure Liquid; Humans; Leucovorin; Stereoisomerism; Tamoxifen; Verapamil; Zidovudine | 1997 |
30 trial(s) available for verapamil and norverapamil
| Article | Year |
|---|---|
Efficacy of conventional and sustained-release verapamil in stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Anti-Arrhythmia Agents; Blood Pressure; Delayed-Action Preparations; Drug Administration Schedule; Drug Therapy, Combination; Heart Rate; Humans; Isosorbide Dinitrate; Male; Middle Aged; Verapamil | 1992 |
The pharmacokinetics of racemic verapamil in patients with impaired renal function.
Topics: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Humans; Infusions, Intravenous; Kidney Failure, Chronic; Verapamil | 1991 |
Influence of food on the bioavailability of a sustained-release verapamil preparation.
Topics: Adult; Aged; Biological Availability; Blood Pressure; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Electrocardiography; Female; Food; Half-Life; Heart Rate; Humans; Male; Middle Aged; Verapamil | 1990 |
Sustained-release and instant-release verapamil in treatment of angina pectoris.
Topics: Angina Pectoris; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Exercise Test; Female; Hemodynamics; Humans; Male; Verapamil | 1989 |
Synergistic adverse hemodynamic interaction between oral verapamil and propranolol.
Topics: Administration, Oral; Adult; Double-Blind Method; Drug Synergism; Hemodynamics; Humans; Male; Physical Exertion; Propranolol; Random Allocation; Verapamil | 1989 |
Pharmacokinetics of calcium channel blocking agents.
Topics: Administration, Oral; Angina Pectoris; Atrial Fibrillation; Biological Availability; Cardiomegaly; Clinical Trials as Topic; Female; Humans; Hypertension; Injections, Intravenous; Kinetics; Liver Cirrhosis; Male; Middle Aged; Nifedipine; Verapamil | 1986 |
Comparisons of verapamil administration twice and three times daily in hypertension.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Verapamil | 1988 |
The effect of verapamil on cardiovascular and metabolic responses to exercise.
Topics: Adult; Blood Pressure; Carbon Dioxide; Clinical Trials as Topic; Double-Blind Method; Female; Heart Rate; Humans; Male; Oxygen Consumption; Physical Exertion; Random Allocation; Verapamil | 1986 |
Pharmacokinetics of verapamil and norverapamil in patients with hypertension: a comparison of oral conventional and sustained release formulations.
Topics: Administration, Oral; Biological Availability; Delayed-Action Preparations; Double-Blind Method; Humans; Hypertension; Random Allocation; Verapamil | 1988 |
Instant and sustained-release verapamil in the treatment of essential hypertension.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Delayed-Action Preparations; Double-Blind Method; Electrocardiography; Heart Rate; Humans; Hypertension; Isometric Contraction; Middle Aged; Nifedipine; Verapamil | 1986 |
A new sustained-release formulation of verapamil in the treatment of hypertension.
Topics: Adult; Clinical Trials as Topic; Delayed-Action Preparations; Electrocardiography; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Verapamil | 1986 |
Clinical and biochemical effects of verapamil administration to schizophrenic patients.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Emotions; Female; Homovanillic Acid; Hostility; Humans; Male; Methoxyhydroxyphenylglycol; Placebos; Prolactin; Schizophrenia; Schizophrenic Psychology; Verapamil | 1987 |
Pharmacokinetics of verapamil in patients with hypertension.
Topics: Administration, Oral; Adult; Double-Blind Method; Drug Administration Schedule; Female; Half-Life; Humans; Hypertension; Kinetics; Male; Middle Aged; Random Allocation; Verapamil | 1986 |
Pharmacokinetics of calcium blockers in patients with renal insufficiency and in geriatric patients.
Topics: Administration, Oral; Adult; Aged; Aging; Diltiazem; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Nifedipine; Uremia; Verapamil | 1984 |
Clinical relevance of verapamil plasma levels in stable angina pectoris.
Topics: Administration, Oral; Aged; Angina Pectoris; Clinical Trials as Topic; Female; Heart Conduction System; Humans; Kinetics; Male; Middle Aged; Physical Exertion; Verapamil | 1982 |
Comparative effects of oral verapamil and propranolol on exercise-induced myocardial ischemia and energetics in patients with coronary artery disease: single-blind placebo crossover evaluation using radionuclide ventriculography.
Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Coronary Disease; Electrocardiography; Exercise Test; Heart Rate; Heart Ventricles; Humans; Middle Aged; Propranolol; Radionuclide Imaging; Stroke Volume; Verapamil | 1982 |
Phase I/II trial of dexverapamil plus vinblastine for patients with advanced renal cell carcinoma.
Topics: Adult; Aged; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bradycardia; Carcinoma, Renal Cell; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Humans; Hypotension; Immunohistochemistry; Kidney Neoplasms; Male; Middle Aged; Stereoisomerism; Tumor Cells, Cultured; Verapamil; Vinblastine | 1995 |
Phase I and pharmacokinetic study of the multidrug resistance modulator dexverapamil with EPOCH chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cross-Over Studies; Cyclophosphamide; Doxorubicin; Drug Resistance, Multiple; Etoposide; Female; Humans; Hypotension; Leukocyte Count; Lymphoma; Male; Middle Aged; Neutrophils; Platelet Count; Prednisone; Sarcoma; Stereoisomerism; Verapamil; Vincristine | 1995 |
Pharmacokinetic parameters of verapamil and its active metabolite norverapamil in patients with hepatopathy.
Topics: Adult; Aged; Antipyrine; Breath Tests; Female; Half-Life; Humans; Hypertension, Portal; Liver Diseases; Male; Middle Aged; Verapamil | 1995 |
Verapamil and norverapamil plasma levels in infants and children during chronic oral treatment.
Topics: Administration, Oral; Adolescent; Aging; Cardiomyopathy, Dilated; Child; Child, Preschool; Female; Half-Life; Humans; Infant; Infant, Newborn; Injections, Intravenous; Male; Tachycardia, Supraventricular; Verapamil | 1995 |
Effects of food on the bioequivalence of different verapamil sustained-release formulations.
Topics: Adult; Chemistry, Pharmaceutical; Delayed-Action Preparations; Drug Administration Schedule; Drugs, Generic; Fasting; Food-Drug Interactions; Humans; Intestinal Absorption; Male; Tablets; Therapeutic Equivalency; Verapamil | 1995 |
Pharmacokinetics of verapamil and norverapamil enantiomers after administration of immediate and controlled-release formulations to humans:evidence suggesting input-rate determined stereoselectivity.
Topics: Adult; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cross-Over Studies; Delayed-Action Preparations; Female; Humans; Male; Middle Aged; Stereoisomerism; Verapamil | 1995 |
The effect of food, time of dosing, and body position on the pharmacokinetics and pharmacodynamics of verapamil and norverapamil.
Topics: Adult; Blood Pressure; Calcium Channel Blockers; Circadian Rhythm; Cross-Over Studies; Drug Administration Schedule; Food; Humans; Male; Middle Aged; Posture; Stereoisomerism; Verapamil | 1995 |
No effect of high-protein food on the stereoselective bioavailability and pharmacokinetics of verapamil.
Topics: Administration, Oral; Adult; Biological Availability; Calcium Channel Blockers; Chromatography; Cross-Over Studies; Dietary Proteins; Drug Interactions; Female; Food; Humans; Male; Stereoisomerism; Verapamil | 1996 |
Pharmacokinetics of verapamil and its metabolite norverapamil from a buccal drug formulation.
Topics: Adhesives; Adult; Area Under Curve; Biological Availability; Calcium Channel Blockers; Chemistry, Pharmaceutical; Female; Half-Life; Humans; Male; Mouth Mucosa; Solubility; Tablets; Verapamil | 2002 |
The effect of gender on the pharmacokinetics of verapamil and norverapamil in human.
Topics: Adult; Area Under Curve; Calcium Channel Blockers; Female; Half-Life; Humans; Male; Sex Characteristics; Verapamil | 2006 |
Drug interaction between oral atorvastatin and verapamil in healthy subjects: effects of atorvastatin on the pharmacokinetics of verapamil and norverapamil.
Topics: Adult; Anticholesteremic Agents; Area Under Curve; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Drug Interactions; Heptanoic Acids; Humans; Male; Pyrroles; Verapamil | 2008 |
Dietary salt does not influence the disposition of verapamil enantiomers in relation to efflux transporter ABCB1 genetic polymorphism in healthy Korean subjects.
Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cross-Over Studies; Haplotypes; Humans; Korea; Male; Point Mutation; Polymorphism, Genetic; Sodium Chloride, Dietary; Stereoisomerism; Verapamil | 2008 |
Pharmacokinetic interaction between oral lovastatin and verapamil in healthy subjects: role of P-glycoprotein inhibition by lovastatin.
Topics: Administration, Oral; Adult; Area Under Curve; Asian People; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Enzyme Inhibitors; Half-Life; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intestinal Absorption; Korea; Lovastatin; Male; Verapamil; Young Adult | 2010 |
Effect of verapamil on the pharmacokinetics of aliskiren in healthy participants.
Topics: Administration, Oral; Adolescent; Adult; Amides; Antihypertensive Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Drug Interactions; Fumarates; Humans; Male; Prospective Studies; Verapamil; Young Adult | 2011 |
131 other study(ies) available for verapamil and norverapamil
| Article | Year |
|---|---|
Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Caco-2 Cells; Calcium Channel Blockers; Cardiotonic Agents; Cell Line; Digoxin; Epithelial Cells; Humans; Kinetics; LLC-PK1 Cells; Nitriles; Swine; Verapamil | 2000 |
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine | 2002 |
Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c.
Topics: Anti-Bacterial Agents; ATP-Binding Cassette Transporters; Bacterial Proteins; Binding Sites; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Molecular Docking Simulation; Molecular Structure; Mycobacterium tuberculosis; Rifampin; Structure-Activity Relationship; Verapamil | 2014 |
Effect of chronic administration of verapamil on Ca++ channel density in rat tissue.
Topics: Animals; Calcium Channels; Delayed-Action Preparations; Female; Injections, Subcutaneous; Rats; Rats, Sprague-Dawley; Verapamil | 1992 |
Internally standardized simultaneous assay of verapamil and N-demethyl-verapamil enantiomers in human plasma by means of high performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Kinetics; Reference Standards; Stereoisomerism; Verapamil | 1992 |
Red blood cell partitioning of gallopamil, verapamil and norverapamil.
Topics: Biological Availability; Chromatography, High Pressure Liquid; Erythrocytes; Gallopamil; Humans; In Vitro Techniques; Regression Analysis; Verapamil | 1992 |
Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects.
Topics: Adult; Biotransformation; Dealkylation; Humans; In Vitro Techniques; Male; Microsomes, Liver; Oxygenases; Stereoisomerism; Verapamil | 1992 |
Simultaneous direct determination of the enantiomers of verapamil and norverapamil in plasma using a derivatized amylose high-performance liquid chromatographic chiral stationary phase.
Topics: Amylose; Chromatography, High Pressure Liquid; Humans; Reproducibility of Results; Spectrometry, Fluorescence; Stereoisomerism; Temperature; Verapamil | 1992 |
Direct determination of the enantiomeric ratio of verapamil, its major metabolite norverapamil and gallopamil in plasma by chiral high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Gallopamil; Humans; Male; Microsomes, Liver; Rats; Rats, Inbred Strains; Reproducibility of Results; Stereoisomerism; Verapamil | 1992 |
Pharmacodynamic profile of verapamil in relation to absolute bioavailability: investigations with a conventional and a controlled-release formulation.
Topics: Administration, Oral; Adult; Biological Availability; Delayed-Action Preparations; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Humans; Infusions, Intravenous; Intestinal Absorption; Male; Verapamil | 1991 |
Electrophysiologic effects of verapamil metabolites in the isolated heart.
Topics: Animals; Atrioventricular Node; Electrophysiology; Female; Heart; Heart Conduction System; Male; Nitriles; Rabbits; Random Allocation; Verapamil | 1991 |
[A chromatographic method of determining verapamil and norverapamil in blood plasma].
Topics: Chromatography, Liquid; Coronary Disease; Humans; Verapamil | 1991 |
Plasma level monitoring of D,L-verapamil and three of its metabolites by reversed-phase high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Spectrometry, Fluorescence; Tachycardia; Verapamil | 1991 |
Dose proportionality of pharmacokinetics with a cr-verapamil formulation.
Topics: Adult; Delayed-Action Preparations; Humans; Male; Middle Aged; Models, Biological; Therapeutic Equivalency; Verapamil | 1991 |
The influence of age on the pharmacokinetics of verapamil.
Topics: Adult; Aged; Aging; Body Weight; Chromatography, High Pressure Liquid; Female; Half-Life; Humans; Hypertension; Male; Middle Aged; Statistics as Topic; Verapamil; Volunteers | 1991 |
Effects of verapamil enantiomers and major metabolites on the cytotoxicity of vincristine and daunomycin in human lymphoma cell lines.
Topics: Daunorubicin; Drug Resistance; Humans; Lymphoma; Protein Binding; Stereoisomerism; Tumor Cells, Cultured; Verapamil; Vincristine | 1991 |
[The effects of slow-release verapamil in relation to plasma concentration in aged hypertensives. A study with continuous monitoring of arterial pressure and electrocardiogram].
Topics: Aged; Blood Pressure; Blood Pressure Monitors; Delayed-Action Preparations; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Verapamil | 1990 |
Effects of the pre-column in automated on-column injection capillary gas chromatography.
Topics: Chromatography, Gas; Humans; Reference Standards; Verapamil | 1990 |
Synthesis and identification of the N-glucuronides of norgallopamil and norverapamil, unusual metabolites of gallopamil and verapamil.
Topics: Animals; Chromatography, High Pressure Liquid; Gallopamil; Gas Chromatography-Mass Spectrometry; Glucuronates; Male; Rats; Rats, Inbred Strains; Stereoisomerism; Verapamil | 1990 |
Requirements for drug monitoring of verapamil: experience from an unselected group of patients with cardiovascular disease.
Topics: Adult; Aged; Aged, 80 and over; Biotransformation; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Monitoring, Physiologic; Nitriles; Regression Analysis; Verapamil | 1990 |
The anaerobic metabolism of verapamil in rat cecal contents forms nor-verapamil and thiocyanate.
Topics: Acetonitriles; Animals; Cecum; Cells, Cultured; Chromatography, High Pressure Liquid; Cyanates; Male; Rats; Rats, Inbred Strains; Substrate Specificity; Thiocyanates; Verapamil | 1990 |
Differences in oral verapamil absorption as a function of time of day.
Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Humans; Intestinal Absorption; Male; Time Factors; Verapamil | 1989 |
Determination of the enantiomers of verapamil and norverapamil in serum using coupled achiral-chiral high-performance liquid chromatography.
Topics: Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Humans; Spectrometry, Fluorescence; Stereoisomerism; Verapamil | 1989 |
Quantitative determination of verapamil and metabolites in human serum by high-performance liquid chromatography and its application to biopharmaceutic investigations.
Topics: Biopharmaceutics; Biotransformation; Chromatography, High Pressure Liquid; Gallopamil; Humans; Indicators and Reagents; Verapamil | 1989 |
Inherent adriamycin resistance in a murine tumour line: circumvention with verapamil and norverapamil.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; Doxorubicin; Drug Resistance; Mice; Tumor Cells, Cultured; Verapamil | 1989 |
Gas chromatographic analysis of verapamil and norverapamil in post mortem specimens using a 530-micron fused-silica column with nitrogen-phosphorus detection.
Topics: Chromatography, Gas; Humans; Nitrogen; Phosphorus; Postmortem Changes; Silicon Dioxide; Verapamil | 1987 |
Assessment of bioavailability of experimental single-unit sustained release tablets of verapamil hydrochloride using the stable isotope technique.
Topics: Absorption; Adult; Biological Availability; Delayed-Action Preparations; Female; Gas Chromatography-Mass Spectrometry; Half-Life; Humans; Kinetics; Male; Solubility; Tablets, Enteric-Coated; Verapamil | 1985 |
4-Aminopyridine and haemodialysis in the treatment of verapamil intoxication.
Topics: 4-Aminopyridine; Aged; Aminopyridines; Atropine; Heart Rate; Humans; Male; Renal Dialysis; Time Factors; Verapamil | 1985 |
The interaction of verapamil and norverapamil with beta-adrenergic receptors.
Topics: Adenylyl Cyclases; Dose-Response Relationship, Drug; Drug Interactions; Humans; Isoproterenol; Lymphocytes; Norepinephrine; Radioligand Assay; Receptors, Adrenergic, beta; Verapamil | 1985 |
Pharmacokinetics of once-daily verapamil: comparative bioavailability of two sustained-release formulations.
Topics: Adult; Biological Availability; Delayed-Action Preparations; Humans; Male; Verapamil | 1988 |
Steady-state cerebrospinal fluid transfer of verapamil and metabolites in patients with schizophrenia.
Topics: Administration, Oral; Adult; Blood Proteins; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Evaluation; Female; Humans; Male; Schizophrenia; Verapamil | 1988 |
Liquid-chromatographic quantification compared with gas-chromatographic-mass-spectrometric determination of verapamil and norverapamil in plasma.
Topics: Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Verapamil | 1988 |
An evaluation of the pharmacokinetics, pharmacodynamics, and dialyzability of verapamil in chronic hemodialysis patients.
Topics: Adult; Aged; Female; Half-Life; Humans; Kidney Failure, Chronic; Male; Middle Aged; Renal Dialysis; Verapamil | 1988 |
The effect of combined therapy on the pharmacokinetics and pharmacodynamics of verapamil and propranolol in patients with angina pectoris.
Topics: Adult; Angina Pectoris; Blood Pressure; Drug Therapy, Combination; Electrocardiography; Heart Rate; Humans; Male; Middle Aged; Physical Exertion; Propranolol; Verapamil | 1988 |
Verapamil in unstable angina pectoris: failure to demonstrate a relationship between efficacy and plasma levels.
Topics: Adult; Aged; Aged, 80 and over; Angina Pectoris; Angina, Unstable; Female; Humans; Male; Middle Aged; Rest; Verapamil | 1988 |
Once a day verapamil in essential hypertension.
Topics: Adult; Aged; Aged, 80 and over; Blood Pressure; Delayed-Action Preparations; Female; Humans; Hypertension; Male; Middle Aged; Renin; Verapamil | 1986 |
Two tricyclic antidepressant poisonings: levels of amitriptyline, nortriptyline and desipramine in post-mortem biological samples.
Topics: Adult; Amitriptyline; Chromatography, High Pressure Liquid; Desipramine; Humans; Male; Nortriptyline; Suicide; Verapamil | 1987 |
Determination of verapamil and norverapamil in human biological material. Investigation of plasma concentrations after oral administration of two different verapamil formulations.
Topics: Administration, Oral; Adult; Biological Availability; Chromatography, High Pressure Liquid; Female; Humans; Male; Spectrometry, Fluorescence; Verapamil | 1987 |
Verapamil and breast-feeding.
Topics: Adult; Breast Feeding; Digoxin; Female; Humans; Milk, Human; Verapamil | 1986 |
Steady state verapamil tissue distribution in the dog: differing tissue accumulation.
Topics: Animals; Blood Pressure; Dogs; Electrocardiography; Male; Myocardium; Tissue Distribution; Verapamil | 1986 |
Pharmacokinetics and dynamics of (+/-)-verapamil in lean and obese Zucker rats.
Topics: Animals; Blood Pressure; Blood Proteins; Body Weight; Disease Models, Animal; Female; Kinetics; Obesity; Protein Binding; Rats; Rats, Zucker; Verapamil | 1986 |
[Dynamics of the anti-anginal effect and of the concentrations of verapamil and its metabolites in the blood serum of patients with stenocardia of exertion].
Topics: Adult; Angina Pectoris; Dose-Response Relationship, Drug; Exercise Test; Humans; Male; Middle Aged; Physical Exertion; Time Factors; Verapamil | 1986 |
Toxicological findings in a fatal overdose of verapamil.
Topics: Adult; Chromatography, Gas; Forensic Medicine; Humans; Male; Suicide; Tissue Distribution; Verapamil | 1986 |
Verapamil and norverapamil in plasma and breast milk during breast feeding.
Topics: Adult; Breast Feeding; Female; Humans; Hypertension; Infant; Infant Nutritional Physiological Phenomena; Metabolic Clearance Rate; Milk, Human; Verapamil | 1987 |
Disposition kinetics and urinary excretion of verapamil and some of its primary metabolites after oral administration in patients with angina pectoris.
Topics: Administration, Oral; Angina Pectoris; Biological Availability; Half-Life; Humans; Kinetics; Male; Middle Aged; Nitriles; Regression Analysis; Verapamil | 1986 |
Simultaneous quantitation of verapamil, norverapamil, and N-dealkylated metabolites in human plasma following oral administration.
Topics: Administration, Oral; Chromatography, Liquid; Dealkylation; Humans; Kinetics; Verapamil | 1985 |
High-performance liquid chromatographic measurement of verapamil in plasma using a diol column.
Topics: Chromatography, High Pressure Liquid; Humans; Verapamil | 1985 |
An investigation of the cause of accumulation of verapamil during regular dosing in patients.
Topics: Adult; Aged; Dealkylation; Female; Half-Life; Humans; Indocyanine Green; Kinetics; Male; Middle Aged; Time Factors; Verapamil | 1985 |
Plasma levels and urinary excretion of verapamil, norverapamil, N-dealkylverapamil (D617), N-dealkylnorverapamil (D620) following oral administration of a slow-release preparation.
Topics: Adult; Cardiac Catheterization; Delayed-Action Preparations; Female; Humans; Kinetics; Male; Middle Aged; Nitriles; Plasma; Verapamil | 1985 |
Pharmacokinetics of verapamil in patients with renal failure.
Topics: Administration, Oral; Adult; Aged; Female; Humans; Injections, Intravenous; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Renal Dialysis; Verapamil | 1985 |
Verapamil kinetics during maintenance hemodialysis.
Topics: Administration, Oral; Half-Life; Humans; Kidney Failure, Chronic; Kinetics; Male; Middle Aged; Renal Dialysis; Tachycardia; Verapamil | 1985 |
Plasma levels and myocardial content of verapamil, norverapamil and two N-dealkyl-metabolites in man.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Coronary Disease; Female; Heart Valve Diseases; Humans; Male; Mathematics; Middle Aged; Models, Biological; Myocardium; Nitriles; Verapamil | 1985 |
Verapamil and norverapamil determination in human plasma by gas-liquid chromatography using nitrogen-phosphorus detection: application to single-dose pharmacokinetic studies.
Topics: Adult; Chromatography, Gas; Half-Life; Humans; Kinetics; Male; Verapamil | 1984 |
Verapamil and propranolol in essential hypertension.
Topics: Adult; Aged; Blood Pressure; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Posture; Propranolol; Random Allocation; Verapamil | 1984 |
The pharmacology of verapamil. V. Tissue distribution of verapamil and norverapamil in rat and dog.
Topics: Animals; Dogs; Male; Rats; Rats, Inbred F344; Species Specificity; Tissue Distribution; Verapamil | 1983 |
Pharmacokinetics of verapamil and norverapamil during long-term oral therapy.
Topics: Aged; Angina Pectoris; Biotransformation; Humans; Kinetics; Male; Middle Aged; Time Factors; Verapamil | 1983 |
Gas-chromatographic determination of verapamil and norverapamil, with a nitrogen-selective detector.
Topics: Chromatography, Gas; Chromatography, Liquid; Humans; Reference Values; Time Factors; Verapamil | 1982 |
Prolongation of verapamil elimination kinetics during chronic oral administration.
Topics: Administration, Oral; Aged; Atrial Fibrillation; Chromatography, High Pressure Liquid; Female; Half-Life; Heart Rate; Humans; Kinetics; Male; Middle Aged; Verapamil | 1982 |
Pharmacokinetics of verapamil: experience with a sustained intravenous infusion regimen.
Topics: Adult; Blood Pressure; Electrocardiography; Female; Heart Rate; Humans; Infusions, Parenteral; Kinetics; Male; Tachycardia, Paroxysmal; Time Factors; Verapamil | 1982 |
Reduced verapamil clearance during long-term oral administration.
Topics: Administration, Oral; Adult; Aged; Female; Half-Life; Humans; Male; Metabolic Clearance Rate; Middle Aged; Verapamil | 1981 |
Rapid high-performance liquid chromatographic method for the measurement of verapamil and norverapamil in blood plasma or serum.
Topics: Chromatography, High Pressure Liquid; Humans; Reference Values; Verapamil | 1981 |
High-performance liquid chromatographic analysis of verapamil. II. Simultaneous quantitation of verapamil and its active metabolite, norverapamil.
Topics: Chromatography, High Pressure Liquid; Humans; Verapamil | 1980 |
Factors affecting the plasma protein binding of verapamil and norverapamil in man.
Topics: Blood Proteins; Humans; In Vitro Techniques; Kinetics; Protein Binding; Time Factors; Verapamil | 1980 |
Input rate-dependent stereoselective pharmacokinetics. Experimental evidence in verapamil-infused isolated rat livers.
Topics: Animals; Liver; Male; Rats; Rats, Sprague-Dawley; Serum Albumin, Bovine; Stereoisomerism; Verapamil | 1995 |
Simultaneous analysis of verapamil and norverapamil enantiomers in human plasma by high-performance liquid chromatography.
Topics: Acetonitriles; Acetylation; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Orosomucoid; Sensitivity and Specificity; Solvents; Spectrometry, Fluorescence; Stereoisomerism; Verapamil | 1995 |
Influence of metabolites on protein binding of verapamil enantiomers.
Topics: Analysis of Variance; Biological Availability; Blood Proteins; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Humans; In Vitro Techniques; Male; Nitriles; Protein Binding; Stereoisomerism; Verapamil | 1995 |
Enantioselective kinetics of verapamil and norverapamil in isolated perfused rat livers.
Topics: Animals; Liver; Male; Metabolic Clearance Rate; Perfusion; Protein Binding; Rats; Rats, Sprague-Dawley; Stereoisomerism; Verapamil | 1994 |
Stereoselective determination of verapamil and norverapamil by capillary electrophoresis.
Topics: Capillary Action; Electrophoresis; Humans; Hydrogen-Ion Concentration; Quality Control; Sensitivity and Specificity; Stereoisomerism; Verapamil | 1994 |
Preliminary investigation of the efficacy of sublingual verapamil in the management of acute atrial fibrillation and flutter.
Topics: Acute Disease; Administration, Sublingual; Aged; Atrial Fibrillation; Atrial Flutter; Chromatography, High Pressure Liquid; Female; Heart Rate; Humans; Male; Middle Aged; Verapamil | 1994 |
Identification of P450 enzymes involved in metabolism of verapamil in humans.
Topics: Biotransformation; Blotting, Western; Cytochrome P-450 Enzyme System; Humans; In Vitro Techniques; Liver; Microsomes, Liver; Mixed Function Oxygenases; Verapamil; Yeasts | 1993 |
Effect of D,L-verapamil, verapamil enantiomers and verapamil metabolites on the binding of vincristine to alpha 1-acid glycoprotein.
Topics: Nitriles; Orosomucoid; Protein Binding; Verapamil; Vincristine | 1993 |
Age and gender related changes in stereoselective pharmacokinetics and pharmacodynamics of verapamil and norverapamil.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Calcium Channel Blockers; Delayed-Action Preparations; Female; Humans; Male; Sex Factors; Stereoisomerism; Verapamil | 1995 |
[Simultaneous determination of verapamil and its major metabolite in human plasma by high performance liquid chromatography].
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Humans; Male; Verapamil | 1995 |
Enantioselective distribution of verapamil and norverapamil into human and rat erythrocytes: the role of plasma protein binding.
Topics: Animals; Blood Proteins; Calcium Channel Blockers; Chromatography, Liquid; Erythrocytes; Humans; Male; Rats; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism; Verapamil | 1996 |
Automated determination of verapamil and norverapamil in human plasma with on-line coupling of dialysis to high-performance liquid chromatography and fluorometric detection.
Topics: Calcium Channel Blockers; Chromatography, High Pressure Liquid; Circadian Rhythm; Dialysis; Humans; Linear Models; Online Systems; Reproducibility of Results; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Verapamil | 1996 |
Pharmacokinetics of verapamil in overdose.
Topics: Adult; Calcium Channel Blockers; Drug Overdose; Female; Half-Life; Humans; Male; Middle Aged; Poisoning; Verapamil | 1997 |
Simultaneous determination of verapamil and norverapamil in biological samples by high-performance liquid chromatography using ultraviolet detection.
Topics: Animals; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Rabbits; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Verapamil | 1997 |
Distribution of verapamil and norverapamil in the eye and systemic circulation after topical administration of verapamil in rabbits.
Topics: Administration, Topical; Animals; Aqueous Humor; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Half-Life; Ophthalmic Solutions; Rabbits; Verapamil; Vitreous Body | 1998 |
Solid-phase extraction-high-performance liquid chromatography determination of verapamil and norverapamil enantiomers in urine.
Topics: Adult; Calcium Channel Blockers; Calibration; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Polytetrafluoroethylene; Reproducibility of Results; Solvents; Specimen Handling; Stereoisomerism; Verapamil | 1998 |
The absence of stereoselective P-glycoprotein-mediated transport of R/S-verapamil across the rat jejunum.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chlorpromazine; Intestinal Absorption; Jejunum; Male; Rats; Stereoisomerism; Vasodilator Agents; Verapamil | 1998 |
Pharmacokinetic and pharmacodynamic effects of high-dose continuous intravenous verapamil infusion: clinical experience in the intensive care unit.
Topics: Adult; Analysis of Variance; Antineoplastic Agents; Calcium Channel Blockers; Critical Care; Doxorubicin; Electrocardiography; Female; Hemodynamics; Humans; Infusions, Intravenous; Linear Models; Male; Middle Aged; Neoplasms; Prospective Studies; Time Factors; Verapamil | 1999 |
Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil.
Topics: Cell Line; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Kinetics; Mixed Function Oxygenases; Nitriles; Stereoisomerism; Substrate Specificity; Tumor Cells, Cultured; Verapamil | 1999 |
Effect of verapamil enantiomers and metabolites on cardiac K+ channels expressed in Xenopus oocytes.
Topics: Animals; Calcium Channel Blockers; Cation Transport Proteins; Ether-A-Go-Go Potassium Channels; Female; Heart; Kv1.1 Potassium Channel; Kv1.5 Potassium Channel; Membrane Potentials; Oocytes; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Potassium Channels, Voltage-Gated; Recombinant Proteins; Stereoisomerism; Verapamil; Xenopus laevis | 1999 |
Repeated oral rifampicin decreases the jejunal permeability of R/S-verapamil in rats.
Topics: Algorithms; Animals; Antibiotics, Antitubercular; Calcium Channel Blockers; Glucose; Intestinal Absorption; Jejunum; Male; Perfusion; Rats; Rats, Sprague-Dawley; Rifampin; Stereoisomerism; Verapamil | 1999 |
In vivo comparison of putative probes of CYP3A4/5 activity: erythromycin, dextromethorphan, and verapamil.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Antitussive Agents; Area Under Curve; Breath Tests; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dextromethorphan; Erythromycin; Female; Humans; Infusions, Intravenous; Linear Models; Male; Middle Aged; Mixed Function Oxygenases; Reference Values; Verapamil | 1999 |
Achiral and chiral HPLC analysis of norverapamil and its metabolites in microsomal samples.
Topics: Biotransformation; Calcium Channel Blockers; Cell Line; Chromatography, High Pressure Liquid; Humans; Isomerism; Microsomes; Verapamil | 1999 |
Enantiometric separation of verapamil and norverapamil using Chiral-AGP as the stationary phase.
Topics: Calcium Channel Blockers; Chromatography, Liquid; Multivariate Analysis; Reproducibility of Results; Stereoisomerism; Temperature; Verapamil | 1999 |
Pharmacokinetics of verapamil in New Zealand white rabbits during ontogeny.
Topics: Aging; Animals; Animals, Newborn; Kinetics; Liver; NADP; Oxidoreductases, N-Demethylating; Rabbits; Verapamil | 2000 |
A validated method for the determination of verapamil and norverapamil in human plasma.
Topics: Calcium Channel Blockers; Calibration; Chromatography, High Pressure Liquid; Fluorescence; Humans; Verapamil | 2001 |
Stereoselective pharmacokinetics and pharmacodynamics of verapamil and norverapamil in rabbits.
Topics: Animals; Area Under Curve; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Injections, Intravenous; Male; Protein Binding; Rabbits; Stereoisomerism; Verapamil | 2001 |
Chiral separation of verapamil and some of its metabolites by HPLC and CE.
Topics: Amylose; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cyclodextrins; Electrophoresis, Capillary; Humans; Indicators and Reagents; Stereoisomerism; Verapamil | 2001 |
Pharmacokinetics of verapamil and norverapamil from controlled release floating pellets in humans.
Topics: Administration, Oral; Adult; Analysis of Variance; Area Under Curve; Calcium Channel Blockers; Delayed-Action Preparations; Drug Compounding; Female; Humans; Male; Sex Factors; Statistics, Nonparametric; Tablets; Verapamil | 2002 |
[Simultaneous determination of the enantiomers of verapamil and norverapamil in plasma by high performance capillary electrophoresis].
Topics: Electrophoresis, Capillary; Humans; Male; Stereoisomerism; Verapamil | 1998 |
Demonstration of direct bioanalysis of drugs in plasma using nanoelectrospray infusion from a silicon chip coupled with tandem mass spectrometry.
Topics: Drug Monitoring; Humans; Pharmaceutical Preparations; Reference Standards; Spectrometry, Mass, Electrospray Ionization; Verapamil | 2003 |
Enantioselective transport and CYP3A4-mediated metabolism of R/S-verapamil in Caco-2 cell monolayers.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Biological Transport; Caco-2 Cells; Cytochrome P450 Family 2; Humans; Intestinal Absorption; Jejunum; Models, Biological; Permeability; Rats; Stereoisomerism; Steroid Hydroxylases; Time Factors; Vasodilator Agents; Verapamil | 2003 |
Verapamil: metabolism in cultures of primary human coronary arterial endothelial cells.
Topics: Aryl Hydrocarbon Hydroxylases; Cell Culture Techniques; Coronary Vessels; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2E1; Endothelium, Vascular; Gene Expression; Humans; Nitriles; Oxidoreductases, N-Demethylating; Recombinant Proteins; Verapamil | 2003 |
Verapamil: identification of novel metabolites in cultures of primary human hepatocytes and human urine by LC-MS(n) and LC-NMR.
Topics: Biotransformation; Calcium Channel Blockers; Cells, Cultured; Chromatography, Liquid; Dealkylation; Hepatocytes; Humans; Hydroxylation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Oxidation-Reduction; Verapamil | 2003 |
Prediction of cytochrome P450 3A inhibition by verapamil enantiomers and their metabolites.
Topics: Administration, Oral; Area Under Curve; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Humans; In Vitro Techniques; Microsomes, Liver; Models, Biological; Stereoisomerism; Verapamil | 2004 |
Simultaneous quantification of the enantiomers of verapamil and its N-demethylated metabolite in human plasma using liquid chromatography-tandem mass spectrometry.
Topics: Biological Availability; Calcium Channel Blockers; Humans; Intestinal Absorption; Mass Spectrometry; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism; Verapamil | 2004 |
The effect of quercetin on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rabbits.
Topics: Animals; Drug Interactions; Male; Quercetin; Rabbits; Verapamil | 2004 |
Kinetic study of CYP3A4 activity on verapamil by capillary electrophoresis.
Topics: Buffers; Calcium Channel Blockers; Chemistry, Pharmaceutical; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Industry; Electrophoresis, Capillary; Kinetics; Models, Chemical; Reproducibility of Results; Temperature; Time Factors; Verapamil | 2005 |
Pharmacokinetics of verapamil and its major metabolite, norverapamil from oral administration of verapamil in rabbits with hepatic failure induced by carbon tetrachloride.
Topics: Administration, Oral; Animals; Biological Availability; Calcium Channel Blockers; Carbon Tetrachloride; Chromatography, High Pressure Liquid; Disease Models, Animal; Liver Failure; Male; Rabbits; Verapamil | 2005 |
Effects of naringin on the pharmacokinetics of verapamil and one of its metabolites, norverapamil, in rabbits.
Topics: Administration, Oral; Animals; Area Under Curve; Biotransformation; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Flavanones; Injections, Intravenous; Male; Rabbits; Verapamil | 2005 |
Chiral capillary electrophoretic analysis of verapamil metabolism by cytochrome P450 3A4.
Topics: Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Electrophoresis, Capillary; Humans; Isoenzymes; Molecular Structure; Reproducibility of Results; Stereoisomerism; Verapamil | 2006 |
Effect of naringin pretreatment on bioavailability of verapamil in rabbits.
Topics: Animals; Antioxidants; Area Under Curve; Biological Availability; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Interactions; Flavanones; Half-Life; Injections, Intravenous; Male; Rabbits; Verapamil | 2006 |
Development of an in vitro rat intestine segmental perfusion model to investigate permeability and predict oral fraction absorbed.
Topics: Animals; Antipyrine; Dealkylation; In Vitro Techniques; Intestinal Absorption; Jejunum; Male; Models, Animal; Naproxen; Perfusion; Permeability; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Testosterone; Verapamil | 2006 |
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
Topics: Amiodarone; Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carbazoles; Carvedilol; Chromatography, Liquid; Diltiazem; Humans; Metoprolol; Mexiletine; Molecular Structure; Propanolamines; Propranolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry; Verapamil | 2007 |
Comparison of sub-2-microm particle columns for fast metabolite ID.
Topics: Chromatography, Liquid; Fluoxetine; Humans; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Particle Size; Pharmaceutical Preparations; Propranolol; Reproducibility of Results; Sensitivity and Specificity; Time Factors; Verapamil | 2007 |
Effects of angiotensin II blockade on inflammation-induced alterations of pharmacokinetics and pharmacodynamics of calcium channel blockers.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; C-Reactive Protein; Calcium Channel Blockers; Calcium Channels, L-Type; Drug Interactions; Inflammation; Male; Nitrendipine; Rats; Rats, Sprague-Dawley; Tetrazoles; Valine; Valsartan; Verapamil | 2008 |
Reduction of enantioselectivity in the kinetic disposition and metabolism of verapamil in rats exposed to toluene.
Topics: Administration, Inhalation; Administration, Oral; Animals; Biotransformation; Calcium Channel Blockers; Chromatography, Liquid; Dose-Response Relationship, Drug; Drug Interactions; Male; Rats; Rats, Wistar; Solvents; Stereoisomerism; Tandem Mass Spectrometry; Toluene; Verapamil | 2008 |
Enhanced bioavailability of verapamil after oral administration with hesperidin in rats.
Topics: Administration, Oral; Animals; Biological Availability; Biotransformation; Calcium Channel Blockers; Drug Interactions; Food-Drug Interactions; Hesperidin; Intestinal Absorption; Male; Models, Biological; Rats; Rats, Sprague-Dawley; Verapamil | 2008 |
Effect of pioglitazone on the pharmacokinetics of verapamil and its major metabolite, norverapamil, in rats.
Topics: Animals; Area Under Curve; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug Interactions; Half-Life; Hypoglycemic Agents; Male; Pioglitazone; Rats; Rats, Sprague-Dawley; Thiazolidinediones; Verapamil | 2008 |
Effects of oral epigallocatechin gallate on the oral pharmacokinetics of verapamil in rats.
Topics: Administration, Oral; Animals; Antioxidants; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Catechin; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Male; Rats; Rats, Sprague-Dawley; Verapamil | 2009 |
Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose.
Topics: Adult; Bradycardia; Calcium Channel Blockers; Delayed-Action Preparations; Drug Overdose; Electrocardiography; Fat Emulsions, Intravenous; Humans; Male; Verapamil | 2009 |
Absorption barriers in the rat intestinal mucosa: 2. Application of physiologically based mathematical models to quantify mechanisms of drug permeation and metabolism.
Topics: Acridines; Adrenergic beta-Antagonists; Algorithms; Animals; Atenolol; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biotransformation; Computer Simulation; Cyclosporins; Cytochrome P-450 CYP3A Inhibitors; Enzyme Inhibitors; Intestinal Absorption; Intestinal Mucosa; Ketoconazole; Models, Statistical; Pharmaceutical Preparations; Rats; Tetrahydroisoquinolines; Verapamil | 2010 |
Effects of lovastatin on the pharmacokinetics of verapamil and its active metabolite, norverapamil in rats: possible role of P-glycoprotein inhibition by lovastatin.
Topics: Administration, Oral; Animals; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Availability; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Drug Interactions; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Metabolic Detoxication, Phase I; Rats; Rats, Sprague-Dawley; Substrate Specificity; Verapamil | 2009 |
Effect of Huang-Lian-Jie-Du-Decoction on pharmacokinetics of verapamil in rats.
Topics: Animals; Area Under Curve; Berberine; Biological Availability; Cytochrome P-450 CYP3A; Drugs, Chinese Herbal; Herb-Drug Interactions; Inactivation, Metabolic; Intestinal Mucosa; Liver; Magnoliopsida; Male; Microsomes; Rats; Rats, Sprague-Dawley; Verapamil | 2010 |
Opposite effect of diabetes mellitus induced by streptozotocin on oral and intravenous pharmacokinetics of verapamil in rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Biological Availability; Calcium Channel Blockers; Cytochrome P-450 CYP3A; Diabetes Mellitus, Experimental; Half-Life; Injections, Intravenous; Intestine, Small; Male; Membrane Proteins; Metabolic Clearance Rate; Microsomes; Microsomes, Liver; Organ Specificity; Rats; Rats, Sprague-Dawley; Streptozocin; Verapamil | 2011 |
Pharmacokinetics of verapamil and its metabolite norverapamil in rats with hyperlipidaemia induced by poloxamer 407.
Topics: Administration, Oral; Animals; Blood Proteins; Hyperlipidemias; Infusions, Intravenous; Male; Microsomes, Liver; Poloxamer; Protein Binding; Rats; Rats, Sprague-Dawley; Verapamil | 2012 |
Enantiomeric separation of verapamil and its active metabolite, norverapamil, and simultaneous quantification in human plasma by LC-ESI-MS-MS.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Stability; Humans; Least-Squares Analysis; Liquid-Liquid Extraction; Male; Middle Aged; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Stereoisomerism; Tandem Mass Spectrometry; Verapamil | 2012 |
Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin.
Topics: Adjuvants, Anesthesia; Anti-Arrhythmia Agents; ATP Binding Cassette Transporter, Subfamily B; Computer Simulation; Digoxin; Drug Interactions; Enzyme Inhibitors; Humans; Midazolam; Models, Biological; Permeability; Rifampin; Verapamil | 2013 |
A semi-physiologically-based pharmacokinetic model characterizing mechanism-based auto-inhibition to predict stereoselective pharmacokinetics of verapamil and its metabolite norverapamil in human.
Topics: Calcium Channel Blockers; Cyclosporine; Cytochrome P-450 CYP3A; Drug Interactions; Gastric Mucosa; Humans; Intestine, Small; Liver; Microsomes, Liver; Midazolam; Models, Biological; Simvastatin; Stereoisomerism; Verapamil | 2013 |
Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil.
Topics: Animals; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B, Member 1; Digoxin; Heptanoic Acids; Intestinal Absorption; Pyrroles; Rats; Rats, Sprague-Dawley; Verapamil | 2013 |
Verapamil, and its metabolite norverapamil, inhibit macrophage-induced, bacterial efflux pump-mediated tolerance to multiple anti-tubercular drugs.
Topics: Antitubercular Agents; Bacterial Proteins; Calcium Channel Blockers; Carrier Proteins; Cell Line; Drug Resistance, Bacterial; Humans; Macrophages; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Verapamil | 2014 |
A pharmacokinetic drug-drug interaction model of simvastatin and verapamil in humans.
Topics: Adult; Antihypertensive Agents; Area Under Curve; Calcium Channel Blockers; Cross-Over Studies; Double-Blind Method; Drug Incompatibility; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Models, Biological; Simvastatin; Verapamil; Young Adult | 2014 |
PBPK modeling to unravel nonlinear pharmacokinetics of verapamil to estimate the fractional clearance for verapamil N-demethylation in the recirculating rat liver preparation.
Topics: Animals; Blood Proteins; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Erythrocytes; Liver; Male; Metabolic Clearance Rate; Models, Biological; Nonlinear Dynamics; Perfusion; Protein Binding; Rats, Sprague-Dawley; Stereoisomerism; Time Factors; Tissue Distribution; Verapamil | 2015 |
Impact of inhalational exposure to ethanol fuel on the pharmacokinetics of verapamil, ibuprofen and fluoxetine as in vivo probe drugs for CYP3A, CYP2C and CYP2D in rats.
Topics: Air Pollutants, Occupational; Animals; Aryl Hydrocarbon Hydroxylases; Atmosphere Exposure Chambers; Biofuels; Biomarkers; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inducers; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Induction; Ethanol; Fluoxetine; Ibuprofen; Inhalation Exposure; Limonene Hydroxylases; Male; Rats, Wistar; Toxicity Tests, Chronic; Verapamil | 2015 |
New Verapamil Analogs Inhibit Intracellular Mycobacteria without Affecting the Functions of Mycobacterium-Specific T Cells.
Topics: Animals; Autophagy; Humans; Isoniazid; Leukocytes, Mononuclear; Macrophage Activation; Macrophages; Mice, Transgenic; Mycobacterium bovis; Mycobacterium tuberculosis; Rifampin; T-Lymphocytes; Verapamil | 2015 |
Assessment of hepatic metabolism-dependent nephrotoxicity on an organs-on-a-chip microdevice.
Topics: Acrolein; Animals; Antineoplastic Agents, Alkylating; Calcium Channel Blockers; Cell Survival; Coculture Techniques; Epithelial Cells; Hep G2 Cells; Humans; Ifosfamide; Kidney; Lab-On-A-Chip Devices; Liver; Phosphoramide Mustards; Rats; Verapamil | 2018 |
Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Atrial Fibrillation; Computer Simulation; Drug Interactions; Humans; Ketoconazole; Kidney; Models, Biological; Organic Anion Transporters, Sodium-Independent; Rivaroxaban; Verapamil | 2019 |
Determination of Verapamil Hydrochloride and Norverapamil Hydrochloride in Rat Plasma by Capillary Electrophoresis With End-Column Electrochemiluminescence Detection and Their Pharmacokinetics Study.
Topics: Animals; Electrophoresis, Capillary; Limit of Detection; Linear Models; Luminescent Measurements; Rats; Rats, Wistar; Reproducibility of Results; Verapamil | 2021 |