verapamil has been researched along with nimodipine in 162 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 60 (37.04) | 18.7374 |
| 1990's | 53 (32.72) | 18.2507 |
| 2000's | 24 (14.81) | 29.6817 |
| 2010's | 24 (14.81) | 24.3611 |
| 2020's | 1 (0.62) | 2.80 |
| Authors | Studies |
|---|---|
| Dietel, M; Höllt, V; Kouba, M; Vogt, G | 1 |
| Janis, RA; Triggle, DJ | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Bruno-Blanch, L; Gálvez, J; García-Domenech, R | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Cuddon, P; Fleming, A; Floto, RA; Goldsmith, P; Jahreiss, L; O'Kane, CJ; Pask, D; Rubinsztein, DC; Saiki, S; Sarkar, S; Siddiqi, FH; Ttofi, EK; Williams, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Andrisano, V; Barril, X; Bartolini, M; Carreiras, Mdo C; de los Ríos, C; García, AG; Huertas, O; León, R; López, B; López, MG; Luque, FJ; Marco-Contelles, J; Rodríguez-Franco, MI; Samadi, A; Villarroya, M | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Arce, MP; Conde, S; del Barrio, L; Egea, J; García, AG; González-Muñoz, GC; León, R; López, B; López, MG; Martín-de-Saavedra, MD; Pérez, C; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Joubert, J; Kapp, E; Malan, SF; Smith, PJ; Taylor, D | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Christie, A; Sharma, VK; Sheu, SS | 1 |
| Montastruc, JL; Senard, JM | 1 |
| De Sarro, A; De Sarro, GB; Nistico', G; Trimarchi, GR | 1 |
| Bustamante, D; Fernandez, E; Kramer, V; Miranda, HF; Paeile, C; Pelissier, T; Pinardi, G; Saavedra, H | 1 |
| Guido, S; Joseph, T | 1 |
| Benedetti, M; Pezzola, A; Popoli, P; Scotti de Carolis, A | 1 |
| Mason, RP; Moisey, DM; Shajenko, L | 1 |
| Lipsey, LR; Reiss, M; Zhou, ZL | 1 |
| Appell, KC; Barrett, RJ; Kilpatrick, BF; Nolan, JC; Proakis, AG; Walsh, DA | 1 |
| Dutar, P; Lamour, Y; Potier, B; Rascol, O | 1 |
| Dong, H; Lu, YQ; Wang, Q; Yang, QQ; Yang, ZC | 1 |
| Fahey, JM; Isaacson, RL | 1 |
| Alabadí, JA; Alborch, E; Alvarez, C; Miranda, FJ; Salom, JB; Torregrosa, G | 1 |
| Campisi, D; Cascio Ingurgio, N; Marsala, BA; Martino, SG; Paterna, S | 1 |
| Köhler, H; Marx, M; Merkel, F; Meyer zum Büschenfelde, KH; Weber, M | 1 |
| Karadzhaeva, GB; Polevik, IV; Vaĭnshteĭn, GB | 1 |
| Handa, J; Kidooka, M; Shiino, A | 1 |
| Ferry, DR; Glossmann, H; Kaumann, AJ | 1 |
| Carpenter, CL; Greenberg, DA; Messing, RO | 1 |
| Richardson, UI | 1 |
| Greenberg, DA | 1 |
| Traber, J; Van Rooijen, LA | 1 |
| Carvalho, AP; Carvalho, CA; Coutinho, OP | 1 |
| Andresen, MC; Kunze, DL; Torres, LA | 1 |
| Anderson, RE; Meyer, FB; Sharbrough, FW; Sundt, TM; Tally, PW; Yaksh, TL | 1 |
| Juhász, O; Orlický, J; Ruscák, M; Zachar, J | 1 |
| Jensen, CB; Norn, S; Skov, PS; Thastrup, O | 1 |
| Angrisani, M; Berrino, L; De Paola, C; De Pasquale, M; De Santis, D; Filippelli, A; Loffreda, A; Maione, S; Matera, C; Mauro, C | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Linn, T | 1 |
| Kunert-Radek, J; Lyson, K; Pawlikowski, M; Radek, A; Stepien, H | 1 |
| Barnett, DB; Walley, TJ; Woods, KL | 1 |
| Ganchev, E | 1 |
| Gachev, E; Karadzhaeva, G | 1 |
| Bae, SJ; Herbette, LG; Kitamura, S; Sturtevant, JM | 1 |
| Janssen, PA; Melis, W; Wauquier, A | 1 |
| Brush, KL; Hamilton, SL; Hawkes, MJ; Perez, M; Pratt, DR | 1 |
| Racker, E; Westcott, D; Wu, LT | 1 |
| Bevan, JA; Hwa, JJ | 1 |
| Flockerzi, V; Hofmann, F; Oeken, J; Ruth, P; von Nettelbladt, E | 1 |
| Bongianni, F; Carla, V; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| Berger, L; Hakim, AM | 1 |
| Bjerrum, PJ; Christensen, SB; Knudsen, JB; Linnebjerg, H; Thastrup, O | 1 |
| Hamberger, A; Lazarewicz, JW; Lehmann, A | 1 |
| Addonizio, P; De Paola, C; De Santis, D; Filippelli, A; Mauro, C; Molinario, L; Russo, S | 1 |
| Cartheuser, CF | 1 |
| Altavilla, D; Berlinghieri, MC; Caputi, AP; Squadrito, F; Sturniolo, R | 1 |
| Amoroso, S; Annunzia, L; Canzoniero, L; Di Renzo, G; Maida, P; Nappi, C; Taglialatela, M | 1 |
| Koidl, B; Tritthart, HA; Wagner, B | 1 |
| Beck, T; Bielenberg, GW; Burniol, M; Krieglstein, J; Sauer, D | 1 |
| Anderson, RE; Ots, ME; Sundt, TM; Yaksh, TL | 1 |
| Jónsdóttir, M; Meyer, JS; Rogers, RL | 1 |
| Karlsson, JA; Nielsen-Kudsk, JE; Persson, CG | 1 |
| Dolin, SJ; Halsey, MJ; Little, HJ | 1 |
| Hakim, AM | 1 |
| Carvalho, AP; Carvalho, CM; Santos, SV | 1 |
| Dowell, RE; Meyer, JS; Nance, M; Walker, M; Zetusky, WJ | 1 |
| Solomon, GD | 2 |
| Aizawa, T; Enyeart, JJ; Hinkle, PM | 1 |
| Anderson, RE; Meyer, FB; Sharbrough, FW; Sundt, TM | 1 |
| Rosenblum, WI | 1 |
| Hager, WD; Katz, AM; Messineo, FC; Pappano, AJ | 1 |
| Bellemann, P | 1 |
| Ferry, DR; Glossmann, H; Goll, A; Schober, M; Striessnig, J | 1 |
| Ferry, DR; Glossmann, H | 1 |
| Gould, RJ; Murphy, KM; Snyder, SH | 1 |
| Hardenberg, J; Meyer, JS | 1 |
| Peroutka, SJ | 1 |
| Honn, KV; Onoda, JM; Sloane, BF | 1 |
| Dowell, R; Hardenberg, J; Mathew, N; Meyer, JS | 1 |
| Clincke, GH; Wauquier, A | 1 |
| Altura, BM; Altura, BT | 1 |
| Kowalski, TE; Taylor, DG | 1 |
| DePover, A; DiSalvo, J; Grupp, G; Grupp, IL; Millard, RW; Schwartz, A | 1 |
| Hachisu, M; Pappano, AJ | 1 |
| Bolger, GT; Gengo, P; Janis, RA; Klockowski, R; Luchowski, E; Siegel, H; Triggle, AM; Triggle, DJ | 1 |
| Isaacson, RL; Varner, JA | 1 |
| Weinstein, GB | 1 |
| Dusseau, J; Hutchins, PM | 1 |
| Filloux, FM; Fitts, RC; Skeen, GA; White, HS | 1 |
| Arneric, SP; Donnelly-Roberts, DL; Sullivan, JP | 1 |
| Martinez-Piñero, MG; Milanés, MV; Vargas, ML | 1 |
| Dai, ZX; Xu, DZ; Yang, ZC; Yao, MH | 1 |
| Goldberg, SR; Prada, J; Schindler, CW; Tella, SR | 1 |
| Hertel, A; Kiwit, JC; Matuschek, AE | 1 |
| Allain, H; Bentué-Ferrer, D; Decombe, R; Saïag, B; Van den Driessche, J | 1 |
| Matsumoto, M; Scheller, MS; Strnat, MA; Zornow, MH | 1 |
| Argov, Z; Brenner, T; Sicsic, C; Wirguin, I | 1 |
| Hair, WM; Hughes, AD; Martin, G; Sever, PS; Sunman, W | 1 |
| Floersheim, GL | 1 |
| Annunziato, L; Canzoniero, LM; Di Renzo, G; Taglialatela, M | 1 |
| Hume, RI; Lin, X; Nuttall, AL | 1 |
| Baldy-Moulinier, M; Diochot, S; Nargeot, J; Richard, S; Valmier, J | 1 |
| Fukui, M; Ikezaki, K; Matsukado, K; Nomura, T | 1 |
| Davidson, RM; Gofa, A | 1 |
| Gunthorpe, MJ; Hargreaves, AC; Lummis, SC; Taylor, CW | 1 |
| Gaur, S; Goodman, HM; Yamaguchi, H | 1 |
| Castleden, CM; Elliott, RA; Norman, RI; Parker, SG; Whitaker, RP | 1 |
| Dumitrescu, A; Haga, Y; Sjöquist, PO; Stain-Malmgren, R; Zhang, Y | 1 |
| De Marco, C; Gornati, D; Silvestrini, R; Villa, R; Zaffaroni, N | 1 |
| Hasegawa, AE; Zacny, JP | 1 |
| Adsan, H; Onaran, O; Tulunay, M | 1 |
| Garrigos, M; Orlowski, S; Pascaud, C | 1 |
| Cárdenas, AM; García, R; Inostroza, O; Pincheira, R; Raffo, M; Vizcarra, J | 1 |
| Antkiewicz-Michaluk, L; Karolewicz, B; Michaluk, J; Vetulani, J | 1 |
| Brust, PF; Hans, M; Harpold, MM; Prodanovich, P; Stauderman, KA; Urrutia, A; Washburn, MS; Williams, ME | 1 |
| Amorim, SC; Costa, PG; Futuro-Neto, HA; Pires, JG; Ribeiro, CA; Saraiva, FP | 1 |
| Dai, DZ; Jiang, JM | 1 |
| Bespalov, AY; Dravolina, OA; Medvedev, IO; Sukhotina, IA | 1 |
| Guan, Z; Saqr, HE; Stokes, BT; Yates, AJ | 1 |
| Deliorman, S; Durmaz, R; Erol, K; Işiksoy, S; Tel, E; Uyar, R | 1 |
| McGrath, JJ; Soares, KV | 1 |
| Bogaert, L; Ebinger, G; Michotte, Y; Moonen, J; O'Neill, MJ; Sarre, S; Smolders, I | 1 |
| Dubey, MP; Kalsotra, A; Kumar, R; Nath, C; Palit, G | 1 |
| Janicak, PG; Levy, NA | 1 |
| Mediratta, PK; Sharma, KK; Verma, V | 1 |
| Li, JX; Liang, JH; Liu, RK; Zhang, Q; Zheng, JW | 1 |
| Connolly, TM; Figueroa, DJ; Lawlor, AM; Liang, HA; Liu, Y; Salata, JJ; Xia, M | 1 |
| Fukazawa, Y; Kishioka, S; Maeda, T; Ozaki, M; Shimizu, N; Yamamoto, C; Yamamoto, H | 1 |
| Chen, B; Han, R; Li, JX; Liang, JH; Lu, Y; Wang, XH; Ye, XF; Zhang, P | 1 |
| Tammela, P; Vuorela, P | 1 |
| Damaj, MI | 1 |
| Badawi, JK; Bross, S; Kamp, S; Kwon, ST; Langbein, S; Li, H | 1 |
| Blatter, XL; Meier, M; Seelig, A; Seelig, J | 1 |
| Bishnoi, M; Chopra, K; Kulkarni, SK | 1 |
| Casassus, G; Fourcaudot, E; Gambino, F; Humeau, Y; Lüthi, A; Poulain, B | 1 |
| Kobayashi, Y; Matsui, T; Tanaka, M; Wang, Z; Watanabe, S | 1 |
| Chatterjee, N; Domoto-Reilly, K; Fecci, PE; Schwamm, LH; Singhal, AB | 1 |
| Biala, G; Budzynska, B; Polak, P | 1 |
| Hashioka, S; Klegeris, A; McGeer, PL | 1 |
| Dong, QX; Gao, JM; He, JH; Huang, CJ; Li, CQ; Xu, YQ; Xuan, YX; Yu, HP; Zhu, JJ | 1 |
| Cao, H; Chu, L; Gao, Y; Ma, J; Wang, J; Zhang, F; Zhang, J; Zhang, X; Zhang, Y | 1 |
| Daschil, N; Humpel, C | 1 |
| Custódio, MR; Ortega, P; Zanotto, FP | 1 |
| Bulsara, KR; Chen, PR; Coulthard, A; Goddard, AJ; Hollingworth, M; Söderman, M | 1 |
| Takeuchi, M; Yamamoto, T | 1 |
| Chang, Y; Chu, L; Chu, X; Gao, Y; Guo, H; Liu, Z; Wang, N; Zhang, J; Zhang, X; Zhang, Y; Zhao, X | 1 |
| Attenburrow, MJ; Cipriani, A; Geddes, JR; Harrison, PJ; Lane, TA; Panchal, P; Saunders, K; Stefaniak, J; Stockton, S; Tunbridge, EM | 1 |
| Chauhan, V; Kulkarni, M; Shetty, S | 1 |
| Al-Mufti, F; Alchaki, A; Dodson, V; El-Ghanem, M; Gupta, G; Hidalgo, A; Nuoman, R; Roychowdhury, S; Sutherland, A; Thabet, A; Wajswol, E | 1 |
| Bacchi, S; Bagster, M; Collins, L; Goh, R; Gupta, A; Kleinig, O; Kleinig, T; Kovoor, J; Lam, L; Proudman, W; Schultz, D; Zhang, R | 1 |
11 review(s) available for verapamil and nimodipine
| Article | Year |
|---|---|
New developments in Ca2+ channel antagonists.
Topics: Animals; Binding Sites; Calcium; Calcium Channel Blockers; Calmodulin; Electrophysiology; Heart; Humans; Ion Channels; Muscle Relaxation; Muscle, Smooth; Potassium; Sodium; Structure-Activity Relationship; Substrate Specificity | 1983 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Calcium channel blockers and prevention of migraine].
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Diltiazem; Flunarizine; Humans; Migraine Disorders; Nifedipine; Nimodipine; Verapamil | 1992 |
[Ca antagonists in neurosurgical practice].
Topics: Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Cerebral Infarction; Disease Models, Animal; Fatty Acids, Nonesterified; Flunarizine; Humans; Intracranial Aneurysm; Ischemic Attack, Transient; Nimodipine; Piperazines; Verapamil | 1990 |
Calcium channel antagonists and the treatment of migraine.
Topics: Calcium; Calcium Channel Blockers; Cinnarizine; Diltiazem; Flunarizine; Humans; Ion Channels; Kinetics; Migraine Disorders; Nicotinic Acids; Nifedipine; Nimodipine; Verapamil | 1986 |
Comparative efficacy of calcium antagonist drugs in the prophylaxis of migraine.
Topics: Calcium Channel Blockers; Cinnarizine; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Flunarizine; Humans; Migraine Disorders; Nicotinic Acids; Nifedipine; Nimodipine; Verapamil | 1985 |
Potential interactions between nimodipine and adrenal hormones.
Topics: Adrenal Cortex; Animals; Corticosterone; Drug Interactions; Ethanol; Humans; Methemoglobin; Nimodipine; Rats; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Verapamil | 1995 |
Diltiazem, nifedipine, nimodipine or verapamil for neuroleptic-induced tardive dyskinesia.
Topics: Antipsychotic Agents; Calcium Channel Blockers; Diltiazem; Dyskinesia, Drug-Induced; Humans; Nifedipine; Nimodipine; Verapamil | 2000 |
Calcium channel antagonists for the treatment of bipolar disorder.
Topics: Antimanic Agents; Bipolar Disorder; Calcium Channel Blockers; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Humans; Lithium Compounds; Nifedipine; Nimodipine; Randomized Controlled Trials as Topic; Verapamil | 2000 |
A systematic review of calcium channel antagonists in bipolar disorder and some considerations for their future development.
Topics: Bipolar Disorder; Calcium Channel Blockers; Calcium Channels, L-Type; Double-Blind Method; Humans; Isradipine; Nimodipine; Verapamil | 2016 |
Verapamil in the treatment of reversible cerebral vasoconstriction syndrome: A systematic review.
Topics: Cerebrovascular Disorders; Humans; Nimodipine; Vasoconstriction; Vasospasm, Intracranial; Verapamil | 2023 |
9 trial(s) available for verapamil and nimodipine
| Article | Year |
|---|---|
[Calcium channel blockers and prevention of migraine].
Topics: Adrenergic beta-Antagonists; Clinical Trials as Topic; Diltiazem; Flunarizine; Humans; Migraine Disorders; Nifedipine; Nimodipine; Verapamil | 1992 |
[Evaluation of the effects of verapamil, flunarizine, diltiazem, nimodipine and placebo in the prevention of hemicrania. A double-blind randomized cross-over study].
Topics: Adolescent; Adult; Diltiazem; Double-Blind Method; Female; Flunarizine; Humans; Male; Middle Aged; Migraine Disorders; Nimodipine; Placebos; Verapamil | 1990 |
Migraine and cluster headache treatment with calcium antagonists supports a vascular pathogenesis.
Topics: Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Female; Hemodynamics; Humans; Male; Nicotinic Acids; Nifedipine; Nimodipine; Vascular Headaches; Verapamil | 1985 |
Comparative efficacy of calcium antagonist drugs in the prophylaxis of migraine.
Topics: Calcium Channel Blockers; Cinnarizine; Clinical Trials as Topic; Diltiazem; Double-Blind Method; Flunarizine; Humans; Migraine Disorders; Nicotinic Acids; Nifedipine; Nimodipine; Verapamil | 1985 |
Clinical effectiveness of calcium entry blockers in prophylactic treatment of migraine and cluster headaches.
Topics: Adult; Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Cluster Headache; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Male; Middle Aged; Migraine Disorders; Nicotinic Acids; Nifedipine; Nimodipine; Random Allocation; Vascular Headaches; Vasomotor System; Verapamil | 1983 |
The pharmacology of calcium channel antagonists: a novel class of anti-migraine agents?
Topics: Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Cyproheptadine; Diltiazem; Humans; Migraine Disorders; Muscle, Smooth, Vascular; Nicotinic Acids; Nifedipine; Nimodipine; Vasomotor System; Verapamil | 1983 |
Clinical and hemodynamic effects during treatment of vascular headaches with verapamil.
Topics: Adult; Aged; Calcium Channel Blockers; Cerebrovascular Circulation; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Nicotinic Acids; Nifedipine; Nimodipine; Vascular Headaches; Verapamil | 1984 |
The influence of three L-type calcium channel blockers on morphine effects in healthy volunteers.
Topics: Adjuvants, Anesthesia; Adult; Affect; Analgesics, Opioid; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Double-Blind Method; Female; Humans; Male; Morphine; Nimodipine; Pain Threshold; Psychomotor Performance; Reference Values; Verapamil | 1997 |
Clinical evaluation of the effect of calcium-channel blockers on verbal learning.
Topics: Adolescent; Adult; Calcium Channel Blockers; Female; Humans; Male; Nimodipine; Verapamil; Verbal Learning | 1998 |
144 other study(ies) available for verapamil and nimodipine
| Article | Year |
|---|---|
Stereoisomers of calcium antagonists which differ markedly in their potencies as calcium blockers are equally effective in modulating drug transport by P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Biological Transport; Calcium Channel Blockers; Cell Line; Dihydropyridines; Drug Resistance; Haplorhini; Immunoblotting; Membrane Glycoproteins; Mice; RNA, Messenger; Stereoisomerism; Verapamil; Vinblastine | 1992 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
Topics: Anticonvulsants; Computer Simulation; Databases, Factual; Discriminant Analysis; Drug Design; Molecular Structure; Quantitative Structure-Activity Relationship | 2003 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Topics: Animals; Autophagy; Calcium Channels, L-Type; Clonidine; Cyclic AMP; Humans; Huntington Disease; Imidazoline Receptors; Minoxidil; Protein Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Type C Phospholipases; Verapamil | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Blood-Brain Barrier; Butyrylcholinesterase; Calcium; Calcium Channel Blockers; Catalytic Domain; Cell Death; Cell Line, Tumor; Cholinesterase Inhibitors; Cytosol; Dihydropyridines; Humans; Hydrogen Peroxide; Kinetics; Ligands; Models, Molecular; Peptide Fragments; Permeability; Tacrine | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Agents; Butyrylcholinesterase; Calcium; Cell Death; Cell Survival; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Molecular Structure; Okadaic Acid; Peptide Fragments; Phenothiazines; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured | 2011 |
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Polycyclic amines as chloroquine resistance modulating agents in Plasmodium falciparum.
Topics: Adamantane; Amines; Animals; Antimalarials; Calcium Channels; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cricetulus; Drug Resistance; Inhibitory Concentration 50; Plasmodium falciparum; Protein Binding; Structure-Activity Relationship | 2016 |
Mechanism of extracellular ATP-induced increase of cytosolic Ca2+ concentration in isolated rat ventricular myocytes.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Caffeine; Calcium; Calcium Channels; Cells, Cultured; Cytosol; Extracellular Space; Heart; Heart Ventricles; Magnesium; Myocardium; Nimodipine; Rats; Ryanodine; Verapamil | 1992 |
Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Anticonvulsants; Body Temperature; Calcium Channel Blockers; Diltiazem; Drug Synergism; Flunarizine; Mice; Mice, Inbred DBA; Nimodipine; Phenobarbital; Phenytoin; Seizures; Valproic Acid; Verapamil | 1992 |
Antinociceptive effects of Ca2+ channel blockers.
Topics: Analgesics; Analysis of Variance; Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Mice; Morphine; Nifedipine; Nimodipine; Pain Measurement; Rats; Rats, Wistar; Verapamil | 1992 |
Effect of chemically different calcium antagonists on lipid profile in rats fed on a high fat diet.
Topics: Animals; Blood; Calcium; Clofibrate; Dietary Fats; Diltiazem; Felodipine; Lipids; Male; Nifedipine; Nimodipine; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Verapamil and flunarizine inhibit phencyclidine-induced effects: an EEG and behavioural study in rats.
Topics: Animals; Behavior, Animal; Electroencephalography; Flunarizine; Injections, Intraventricular; Male; Nimodipine; Phencyclidine; Rats; Rats, Wistar; Verapamil | 1992 |
Cholesterol alters the binding of Ca2+ channel blockers to the membrane lipid bilayer.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Cattle; Cell Membrane; Cholesterol; Dihydropyridines; Diltiazem; Electrons; Isradipine; Lipid Bilayers; Myocardium; Nifedipine; Nimodipine; Nitrendipine; Phosphatidylcholines; Rabbits; Verapamil | 1992 |
Extracellular calcium-dependent regulation of transmembrane calcium fluxes in murine keratinocytes.
Topics: Animals; Calcium; Calcium Channels; Cell Line; Cobalt; Keratinocytes; Lanthanum; Mice; Nickel; Nimodipine; Nitrendipine; Verapamil | 1991 |
AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels.
Topics: Animals; Atrial Function; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Diuresis; Dose-Response Relationship, Drug; Edema; Guinea Pigs; Heart Atria; Ketanserin; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nimodipine; Piperidines; Platelet Aggregation; Propiophenones; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Histamine H1; Receptors, Serotonin; Reflex; Serotonin; Serotonin Antagonists; Tritium; Verapamil | 1991 |
Effects of calcium channel agonist and antagonists on calcium-dependent events in CA1 hippocampal neurons.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium; Calcium Channel Blockers; Calcium Channels; Hippocampus; Male; Neurons; Nimodipine; omega-Conotoxin GVIA; Peptides, Cyclic; Rats; Rats, Inbred Strains; Synapses; Verapamil | 1991 |
Antagonistic effects of dihydropyridines and verapamil on CaCl2 and 5-HT-evoked contraction in porcine coronary artery.
Topics: Animals; Calcium Chloride; Coronary Vessels; Dihydropyridines; Felodipine; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nifedipine; Nimodipine; Serotonin Antagonists; Swine; Verapamil | 1991 |
Pretreatment effects on nitrite-induced methemoglobinemia: saline and calcium channel antagonists.
Topics: Animals; Calcium Channel Blockers; Male; Methemoglobinemia; Nimodipine; Rats; Sodium Chloride; Sodium Nitrite; Verapamil | 1990 |
Effects of Ca2+ entry blockers on CaCl2-, KCl- and noradrenaline-induced contractions of goat cerebral arteries.
Topics: Animals; Calcium Channel Blockers; Calcium Chloride; Cerebral Arteries; Egtazic Acid; Female; Goats; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nicardipine; Nimodipine; Norepinephrine; Potassium Chloride; Verapamil | 1990 |
Additive effects of calcium antagonists on cyclosporin A-induced inhibition of T-cell proliferation.
Topics: Adult; Antibodies, Monoclonal; Calcium Channel Blockers; Cyclosporins; Diltiazem; Drug Synergism; Humans; In Vitro Techniques; Lymphocyte Activation; Lymphocyte Culture Test, Mixed; Nifedipine; Nimodipine; Phytohemagglutinins; T-Lymphocytes; Verapamil | 1990 |
[The effect of a calcium channel blockade on the reactivity of the cerebral vessels in rabbits].
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cerebral Arteries; Cerebral Cortex; Dose-Response Relationship, Drug; Electrodes, Implanted; Hypothalamus; Nimodipine; Rabbits; Thalamus; Time Factors; Verapamil | 1990 |
Relationship between the stereoselective negative inotropic effects of verapamil enantiomers and their binding to putative calcium channels in human heart.
Topics: Aged; Binding Sites; Calcium; Depression, Chemical; Female; Humans; Ion Channels; Kinetics; Male; Middle Aged; Myocardial Contraction; Myocardium; Nicotinic Acids; Nimodipine; Stereoisomerism; Tritium; Verapamil | 1985 |
Mechanism of calcium channel inhibition by phenytoin: comparison with classical calcium channel antagonists.
Topics: Adrenal Gland Neoplasms; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Carbachol; Cell Line; Cinnarizine; Diltiazem; Flunarizine; Ion Channels; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Phenytoin; Pheochromocytoma; Potassium; Rats; Sodium; Verapamil | 1985 |
Multiple classes of calcium channels in mouse pituitary tumor cells.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Cell Membrane; Clone Cells; Cobalt; Corticotropin-Releasing Hormone; Egtazic Acid; Ion Channels; Lanthanum; Mice; Nicotinic Acids; Nimodipine; Pituitary Neoplasms; Potassium; Verapamil | 1986 |
Muscarinic cholinergic enhancement of inositide turnover in cerebral nerve endings is not mediated by calcium uptake.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcimycin; Calcium; Carbachol; Cinnarizine; Flunarizine; Male; Nerve Endings; Nicotinic Acids; Nifedipine; Nimodipine; Phosphatidic Acids; Phosphatidylinositols; Rats; Rats, Inbred Strains; Verapamil; Veratridine | 1986 |
Effects of Ca2+ channel blockers on Ca2+ translocation across synaptosomal membranes.
Topics: Adenosine Triphosphatases; Animals; Binding Sites; Calcium; Calcium Channel Blockers; Diltiazem; Ion Channels; Nifedipine; Nimodipine; Sheep; Subcellular Fractions; Synaptic Membranes; Synaptosomes; Verapamil | 1986 |
Do calcium antagonists act directly on calcium channels to alter baroreceptor function?
Topics: Animals; Blood Pressure; Calcium; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Ion Channels; Nifedipine; Nimodipine; Nitrendipine; Pressoreceptors; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker.
Topics: Animals; Catheterization; Cerebral Cortex; Dose-Response Relationship, Drug; Electric Stimulation; Injections, Intra-Arterial; Ion Channels; Nimodipine; Phenytoin; Rabbits; Seizures; Verapamil | 1986 |
Inhibition of Na+-Ca2+ exchange by calcium antagonists in rat brain microsomal membranes.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Intracellular Membranes; Ion Channels; Ion Exchange; Microsomes; Nifedipine; Nimodipine; Pronase; Rats; Rats, Inbred Strains; Sodium; Verapamil | 1986 |
Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils: effect of pretreatment with sialidase.
Topics: Basophils; Cell Membrane; Histamine Release; Humans; Lanthanum; Neuraminidase; Nimodipine; Sialic Acids; Verapamil | 1987 |
Interference of prenatal and postnatal exposure to Ca2+-antagonist agents on rat functional development of vascular system.
Topics: Acetylcholinesterase; Animals; Animals, Newborn; Blood Pressure; Body Weight; Calcium Channel Blockers; Cardiovascular System; Catecholamines; Diltiazem; Dose-Response Relationship, Drug; Female; Gestational Age; Heart Rate; Male; N-Glycosyl Hydrolases; Nimodipine; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Vasomotor System; Verapamil | 1989 |
Molecular approach to the calcium channel.
Topics: Animals; Benzothiazoles; Binding Sites; Brain; Calcium; Cattle; Chemical Phenomena; Chemistry; Diltiazem; Guinea Pigs; In Vitro Techniques; Ion Channels; Isradipine; Muscles; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Oxadiazoles; Thiazoles; Verapamil | 1985 |
Inhibitory effect of calcium channel blockers on proliferation of human glioma cells in vitro.
Topics: Calcium; Calcium Channel Blockers; Cell Division; Glioma; Humans; Nimodipine; Thymidine; Tumor Cells, Cultured; Verapamil | 1989 |
Effects of calcium channel blockers on in vitro platelet function in whole blood using single platelet counting.
Topics: Adult; Calcium Channel Blockers; Collagen; Diltiazem; Epinephrine; Female; Humans; In Vitro Techniques; Male; Nifedipine; Nimodipine; Platelet Aggregation Inhibitors; Platelet Count; Verapamil | 1989 |
[The effect of the calcium antagonists nimodipin, verapamil and diltiazem on local cerebral blood flow of the cortex and thalamus in cats].
Topics: Animals; Cats; Cerebral Cortex; Diltiazem; Nimodipine; Regional Blood Flow; Thalamus; Verapamil | 1989 |
[The effect of calcium antagonists nimodipin, verapamil, diltiazem and flunarizin on local cerebral blood flow in rabbits in chronic experiments].
Topics: Animals; Cerebral Cortex; Diltiazem; Female; Flunarizine; Male; Nimodipine; Rabbits; Regional Blood Flow; Verapamil | 1989 |
The effects of calcium channel blocking drugs on the thermotropic behavior of dimyristoylphosphatidylcholine.
Topics: Calcium Channel Blockers; Calorimetry, Differential Scanning; Diltiazem; Dimyristoylphosphatidylcholine; Models, Biological; Nifedipine; Nimodipine; Nisoldipine; Thermodynamics; Verapamil | 1989 |
Long-term neurological assessment of the post-resuscitative effects of flunarizine, verapamil and nimodipine in a new model of global complete ischaemia.
Topics: Anesthesia; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Electromyography; Flunarizine; Injections, Intravenous; Ischemia; Male; Nimodipine; Rats; Reflex; Resuscitation; Verapamil | 1989 |
Low affinity binding sites for 1,4-dihydropyridines in mitochondria and in guinea pig ventricular membranes.
Topics: Animals; Calcium Channels; Cations, Divalent; Cell Membrane; Diltiazem; Guinea Pigs; Heart Ventricles; Hot Temperature; Mitochondria; Myocardium; Nimodipine; Nitrendipine; Osmolar Concentration; Protein Denaturation; Receptors, Nicotinic; Sodium Chloride; Verapamil | 1987 |
Use of slow Ca2+ channel blockers to enhance inhibition by taxol of growth of drug-sensitive and -resistant Chinese hamster ovary cells.
Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Calcium Channel Blockers; Cell Division; Cells, Cultured; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Nicotinic Acids; Nimodipine; Ovary; Paclitaxel; Pimozide; Verapamil | 1986 |
A nimodipine-resistant Ca2+ pathway is involved in myogenic tone in a resistance artery.
Topics: Analysis of Variance; Animals; Arteries; Calcium; Diltiazem; Dose-Response Relationship, Drug; Drug Resistance; Isradipine; Male; Manganese; Muscle, Smooth, Vascular; Nicotinic Acids; Nimodipine; Oxadiazoles; Potassium; Rabbits; Vascular Resistance; Verapamil | 1986 |
Characterization of the binding sites for nimodipine and (-)-desmethoxyverapamil in bovine cardiac sarcolemma.
Topics: Animals; Binding Sites; Calcium Channel Blockers; Calcium Channels; Calcium Chloride; Cattle; Diltiazem; Egtazic Acid; In Vitro Techniques; Kinetics; Myocardium; Nicotinic Acids; Nimodipine; Receptors, Nicotinic; Sarcolemma; Tritium; Verapamil | 1985 |
Calcium channel inhibitors suppress the morphine-withdrawal syndrome in rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Methoxyhydroxyphenylglycol; Morphine; Morphine Dependence; Naloxone; Nicotinic Acids; Nimodipine; Norepinephrine; Rats; Receptors, Opioid; Substance Withdrawal Syndrome; Verapamil | 1986 |
Calcium channel blockers correct acidosis in ischemic rat brain without altering cerebral blood flow.
Topics: Acidosis; Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Epoprostenol; Hydrogen-Ion Concentration; Male; Nimodipine; Rats; Rats, Inbred Strains; Verapamil | 1988 |
The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylations.
Topics: Blood Platelets; Calcimycin; Calcium; Cytoplasm; Diltiazem; Humans; Kinetics; Molecular Weight; Nimodipine; Phosphoproteins; Plant Extracts; Platelet Aggregation; Serotonin; Tetradecanoylphorbol Acetate; Thapsigargin; Thrombin; Verapamil | 1987 |
Effects of Ca2+ entry blockers on kainate-induced changes in extracellular amino acids and Ca2+ in vivo.
Topics: Amino Acids; Animals; Calcium; Calcium Channel Blockers; Cobalt; Flunarizine; Hippocampus; Kainic Acid; Nimodipine; Rabbits; Verapamil | 1987 |
Effects of prenatal and postnatal exposure to Ca2+-antagonist agents on rat vasomotor reactivity development.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Carotid Sinus; Diltiazem; Female; Nimodipine; Norepinephrine; Pregnancy; Pressoreceptors; Rats; Verapamil | 1988 |
Slow channel inhibitor effects on brain function: tolerance to severe hypoxia in the rat.
Topics: Animals; Bencyclane; Bepridil; Brain; Calcium Channel Blockers; Cinnarizine; Diltiazem; Electroencephalography; Fendiline; Flunarizine; Gallopamil; Heart Rate; Hypoxia; Nimodipine; Prenylamine; Pyrrolidines; Rats; Rats, Inbred Strains; Respiration; Verapamil | 1988 |
Splanchnic artery occlusion shock in the rat: effects of the calcium entry blockers nimodipine and verapamil.
Topics: Animals; Arterial Occlusive Diseases; Female; Leukocyte Count; Leukocytes; Nimodipine; Phagocytosis; Rats; Rats, Inbred Strains; Shock; Splanchnic Circulation; Verapamil | 1988 |
Effect of different Ca2+ entry blockers on dopamine-induced inhibition of in vitro prolactin secretion.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dopamine Antagonists; Flunarizine; In Vitro Techniques; Nimodipine; Prolactin; Rats; Rats, Inbred Strains; Receptors, Dopamine; Verapamil | 1988 |
The inhibitory effects of the novel calcium antagonist Goe 5438 on calcium-dependent processes of excitation and contraction of single cardiomyocytes.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Chick Embryo; Guinea Pigs; In Vitro Techniques; Membrane Potentials; Myocardial Contraction; Myocardium; Naphthyridines; Nimodipine; Verapamil | 1988 |
Effects of cerebroprotective agents on cerebral blood flow and on postischemic energy metabolism in the rat brain.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Energy Metabolism; Furans; Ketamine; Male; Nafronyl; Nimodipine; Rats; Rats, Inbred Strains; Verapamil | 1987 |
Effect of dihydropyridines and diphenylalkylamines on pentylenetetrazol-induced seizures and cerebral blood flow in cats.
Topics: Animals; Anticonvulsants; Brain; Calcium Channel Blockers; Cats; Cerebrovascular Circulation; Clonazepam; Electroencephalography; Female; Male; Nimodipine; Pentylenetetrazole; Phenytoin; Seizures; Verapamil | 1987 |
Efficacy, side effects and tolerance compared during headache treatment with three different calcium blockers.
Topics: Adult; Calcium Channel Blockers; Female; Humans; Male; Middle Aged; Nifedipine; Nimodipine; Vascular Headaches; Verapamil | 1987 |
Relaxant effects of xanthines, a beta 2-receptor agonist and Ca2+ antagonists in guinea-pig tracheal preparations contracted by potassium or carbachol.
Topics: Animals; Bronchodilator Agents; Carbachol; Female; Guinea Pigs; Male; Muscle, Smooth; Nimodipine; Parasympatholytics; Potassium; Terbutaline; Theophylline; Trachea; Verapamil; Xanthines | 1986 |
Calcium channel antagonists decrease the ethanol withdrawal syndrome.
Topics: Animals; Calcium Channel Blockers; Diazepam; Ethanol; Flunarizine; Male; Motor Activity; Nimodipine; Nitrendipine; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Substance Withdrawal Syndrome; Verapamil | 1986 |
Cerebral acidosis in focal ischemia: II. Nimodipine and verapamil normalize cerebral pH following middle cerebral artery occlusion in the rat.
Topics: Acidosis; Animals; Arterial Occlusive Diseases; Brain; Brain Diseases; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Cerebrovascular Disorders; Hydrogen-Ion Concentration; Male; Nimodipine; Rats; Rats, Inbred Strains; Verapamil | 1986 |
gamma-Aminobutyric acid release from synaptosomes as influenced by Ca2+ and Ca2+ channel blockers.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cell Membrane; gamma-Aminobutyric Acid; In Vitro Techniques; Nimodipine; Potassium; Sheep; Sodium; Synaptosomes; Verapamil | 1986 |
Dihydropyridine Ca2+ antagonists: potent inhibitors of secretion from normal and transformed pituitary cells.
Topics: Animals; Calcium Channel Blockers; Cell Line; Growth Hormone; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Pituitary Gland; Pituitary Neoplasms; Potassium Chloride; Prolactin; Rats; Thyrotropin-Releasing Hormone; Verapamil | 1985 |
Selective central nervous system calcium channel blockers--a new class of anticonvulsant agents.
Topics: Animals; Anticonvulsants; Bicuculline; Calcium Channel Blockers; Central Nervous System; Convulsants; Drug Evaluation, Preclinical; Electroencephalography; Ischemia; Nicotinic Acids; Nimodipine; Pentylenetetrazole; Perfusion; Rabbits; Seizures; Verapamil | 1986 |
Inhibition of barium-induced constriction of cerebral surface arterioles by blockers of calcium channels.
Topics: Animals; Barium; Barium Compounds; Calcium Channel Blockers; Chlorides; Constriction, Pathologic; Male; Mice; Nicotinic Acids; Nimodipine; Pia Mater; Verapamil | 1985 |
Cellular actions and pharmacology of calcium-channel blockers.
Topics: Actins; Action Potentials; Calcium; Calcium Channel Blockers; Cell Membrane; Drug Interactions; Extracellular Space; Heart; Homeostasis; Humans; Muscle Contraction; Muscle, Smooth; Myocardial Contraction; Myosins; Nicotinic Acids; Nifedipine; Nimodipine; Verapamil | 1985 |
Interaction of the calcium channel activating 3H-BAY K 8644 and inhibiting 3H-verapamil with specific receptor sites on cultured beating myocardial cells.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Brain; Calcium; Calcium Channel Blockers; Cells, Cultured; Kinetics; Myocardial Contraction; Myocardium; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Nitrendipine; Receptors, Drug; Verapamil | 1984 |
(-)-[3H]Desmethoxyverapamil, a novel Ca2+ channel probe. Binding characteristics and target size analysis of its receptor in skeletal muscle.
Topics: Animals; Binding Sites; Calcium; Diltiazem; Guinea Pigs; Ion Channels; Kinetics; Muscles; Nicotinic Acids; Nimodipine; Stereoisomerism; Subcellular Fractions; Verapamil | 1984 |
Evidence of multiple receptor sites within the putative calcium channel.
Topics: Animals; Brain; Calcium; Calcium Channel Blockers; Diltiazem; Guinea Pigs; In Vitro Techniques; Ion Channels; Kinetics; Membranes; Nicotinic Acids; Nimodipine; Prenylamine; Receptors, Drug; Verapamil | 1982 |
A simple sensitive radioreceptor assay for calcium antagonist drugs.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Calcium Channels; Cattle; Cell Membrane; Cerebral Cortex; Diltiazem; In Vitro Techniques; Muscles; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Prenylamine; Radioligand Assay; Receptors, Nicotinic; Verapamil | 1983 |
Antithrombogenic effects of calcium channel blockers: synergism with prostacyclin and thromboxane synthase inhibitors.
Topics: Adenosine Diphosphate; Benzofurans; Blood Platelets; Calcium Channel Blockers; Diltiazem; Drug Synergism; Epoprostenol; Humans; Nicotinic Acids; Nifedipine; Nimodipine; Oxidoreductases; Platelet Aggregation; Thrombin; Thromboxane A2; Thromboxane-A Synthase; Verapamil | 1984 |
Pharmacological protection against hypoxia-induced effects on medium-term memory in a two-way avoidance paradigm.
Topics: Animals; Avoidance Learning; Calcium Channel Blockers; Cerebral Cortex; Cinnarizine; Dose-Response Relationship, Drug; Flunarizine; Guinea Pigs; Hypoxia, Brain; Male; Memory; Mental Recall; Nicotinic Acids; Nifedipine; Nimodipine; Retention, Psychology; Vasodilation; Verapamil | 1984 |
Pharmacologic inhibition of cerebral vasospasm in ischemia, hallucinogen ingestion, and hypomagnesemia: barbiturates, calcium antagonists, and magnesium.
Topics: Animals; Barbiturates; Brain Ischemia; Calcium Channel Blockers; Cerebral Arteries; Magnesium; Metabolic Diseases; Microcirculation; Nicotinic Acids; Nifedipine; Nimodipine; Nisoldipine; Phencyclidine; Rats; Verapamil; Water Supply | 1983 |
Comparison of calcium channel inhibitors on vagal heart rate responses elicited by arterial baroreceptor reflexes in anesthetized dogs.
Topics: Acetylcholine; Anesthesia; Animals; Calcium Channel Blockers; Diltiazem; Dogs; Heart Rate; In Vitro Techniques; Male; Nicotinic Acids; Nifedipine; Nimodipine; Nitroprusside; Norepinephrine; Pressoreceptors; Reflex; Vagus Nerve; Verapamil | 1984 |
Calcium channel blockers and migraine.
Topics: Humans; Migraine Disorders; Nicotinic Acids; Nimodipine; Verapamil | 1984 |
Chronotropic, inotropic, and vasodilator actions of diltiazem, nifedipine, and verapamil. A comparative study of physiological responses and membrane receptor activity.
Topics: Animals; Benzazepines; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Diltiazem; Dogs; Guinea Pigs; Heart Rate; In Vitro Techniques; Myocardial Contraction; Nicotinic Acids; Nifedipine; Nimodipine; Potassium; Pyridines; Receptors, Drug; Vasodilation; Verapamil | 1983 |
A comparative study of the blockade of calcium-dependent action potentials by verapamil, nifedipine and nimodipine in ventricular muscle.
Topics: Action Potentials; Animals; Calcium; Calcium Channel Blockers; Chickens; Electrophysiology; Heart Ventricles; Muscles; Nicotinic Acids; Nifedipine; Nimodipine; Ventricular Function; Verapamil | 1983 |
Characterization of binding of the Ca++ channel antagonist, [3H]nitrendipine, to guinea-pig ileal smooth muscle.
Topics: Animals; Binding Sites; Binding, Competitive; Calcium Channel Blockers; Cinnarizine; Cobalt; Dose-Response Relationship, Drug; Drug Synergism; Flunarizine; Guinea Pigs; Ileum; Kinetics; Male; Muscle Contraction; Muscle, Smooth; Nicotinic Acids; Nifedipine; Nimodipine; Nitrendipine; Pyridines; Structure-Activity Relationship; Verapamil | 1983 |
Effects of nimodipine and verapamil on cerebral blood flow and cerebrovascular reactivity in conscious rabbits.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cerebral Cortex; Cerebrovascular Circulation; Hypothalamus; Male; Nimodipine; Rabbits; Reference Values; Regional Blood Flow; Thalamus; Verapamil | 1995 |
Calcium entry blockers stimulate vasoproliferation on the chick chorioallantoic membrane.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Allantois; Animals; Cell Division; Chick Embryo; Chorion; Dose-Response Relationship, Drug; Nifedipine; Nimodipine; Verapamil | 1993 |
The dihydropyridine nitrendipine inhibits [3H]MK 801 binding to mouse brain sections.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analysis of Variance; Animals; Autoradiography; Binding, Competitive; Brain; Calcium; Dizocilpine Maleate; Dose-Response Relationship, Drug; Male; Mice; N-Methylaspartate; Nifedipine; Nimodipine; Nitrendipine; Software; Verapamil | 1994 |
Functional modulation of human "ganglionic-like" neuronal nicotinic acetylcholine receptors (nAChRs) by L-type calcium channel antagonists.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Cadmium; Calcium Channel Blockers; Calcium Channels; Diltiazem; Humans; Isradipine; Neuroblastoma; Neurons; Nicotine; Nifedipine; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Peptides; Receptors, Nicotinic; Spider Venoms; Tumor Cells, Cultured; Verapamil | 1995 |
L-type Ca2+ channel ligands modulate morphine effects on the hypothalamus-pituitary-adrenocortical axis in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Corticosterone; Dopamine; Drug Synergism; Hypothalamo-Hypophyseal System; Male; Morphine; Neurosecretory Systems; Nimodipine; Norepinephrine; Pituitary-Adrenal System; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Verapamil | 1993 |
Effects of nimodipine, felodipine, and verapamil on isolated human arteries.
Topics: Adult; Calcium Chloride; Felodipine; Female; Humans; In Vitro Techniques; Male; Mesenteric Arteries; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Nimodipine; Norepinephrine; Renal Artery; Verapamil | 1995 |
Calcium channel blockers antagonize some of cocaine's cardiovascular effects, but fail to alter cocaine's behavioral effects.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cocaine; Conditioning, Psychological; Diltiazem; Heart Rate; Male; Nimodipine; Saimiri; Self Administration; Verapamil | 1995 |
Reversal of chemoresistance in malignant gliomas by calcium antagonists: correlation with the expression of multidrug-resistant p-glycoprotein.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cisplatin; Drug Resistance; Glioblastoma; Humans; Immunoenzyme Techniques; Nimodipine; Nimustine; Phenotype; Tumor Cells, Cultured; Verapamil; Vincristine | 1994 |
L-type voltage-dependent calcium channels do not modulate aminergic neurotransmitter release induced by transient global cerebral ischaemia: an in vivo microdialysis study in rat.
Topics: Animals; Biogenic Monoamines; Biological Availability; Calcium Channels; Corpus Striatum; Dialysis; Diltiazem; Injections; Ischemic Attack, Transient; Male; Neurotransmitter Agents; Nimodipine; Rats; Rats, Sprague-Dawley; Verapamil | 1993 |
Effect of S-emopamil, nimodipine, and mild hypothermia on hippocampal glutamate concentrations after repeated cerebral ischemia in rabbits.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Glutamates; Glutamic Acid; Hippocampus; Hypothermia; Nimodipine; Osmolar Concentration; Rabbits; Recurrence; Verapamil | 1993 |
Variable effect of calcium channel blockers on the decremental response in experimental autoimmune myasthenia gravis.
Topics: Action Potentials; Animals; Electric Stimulation; Muscles; Myasthenia Gravis; Nimodipine; Rabbits; Time Factors; Verapamil | 1994 |
Effect of calcium antagonists on endothelin-induced contraction of isolated human resistance arteries: differences related to site of origin.
Topics: Adipose Tissue; Adult; Aged; Arteries; Calcium Channel Blockers; Calcium Channels; Diltiazem; Endothelins; Flunarizine; Humans; Membrane Potentials; Middle Aged; Muscle Contraction; Muscle, Smooth, Vascular; Myography; Nimodipine; Nisoldipine; Omentum; Vasoconstriction; Verapamil | 1993 |
Radioprotective effects of calcium antagonists used alone or with other types of radioprotectors.
Topics: Animals; Aspartic Acid; Calcium Channel Blockers; Diltiazem; Dimethyl Sulfoxide; Drug Combinations; Female; Flunarizine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Nifedipine; Nimodipine; Nitrendipine; Radiation-Protective Agents; Verapamil; Zinc | 1993 |
Gadolinium and neomycin block voltage-sensitive Ca2+ channels without interfering with the Na(+)-Ca2+ antiporter in brain nerve endings.
Topics: Animals; Brain Chemistry; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Carrier Proteins; Fura-2; Gadolinium; In Vitro Techniques; Male; Membrane Proteins; Neomycin; Nerve Endings; Nerve Tissue Proteins; Nimodipine; Potassium; Rats; Rats, Wistar; Sodium-Calcium Exchanger; Synaptosomes; Verapamil | 1993 |
Dihydropyridines and verapamil inhibit voltage-dependent K+ current in isolated outer hair cells of the guinea pig.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 4-Aminopyridine; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Cochlea; Guinea Pigs; Hair Cells, Auditory, Outer; Membrane Potentials; Nifedipine; Nimodipine; Patch-Clamp Techniques; Potassium Channel Blockers; Quinine; Verapamil | 1995 |
Dihydropyridines, phenylalkylamines and benzothiazepines block N-, P/Q- and R-type calcium currents.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Diltiazem; Ganglia, Spinal; Heart; Homovanillic Acid; In Vitro Techniques; Ion Channel Gating; Mice; Motor Neurons; Myocardium; Neurons, Afferent; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Rats; Rats, Sprague-Dawley; Spider Venoms; Verapamil | 1995 |
Effect of calcium antagonists on regional cerebral blood flow in transplanted rat brain tumors.
Topics: Analysis of Variance; Animals; Brain; Brain Neoplasms; Calcium Channel Blockers; Cerebrovascular Circulation; Diltiazem; Flunarizine; Glioma; Male; Neoplasm Transplantation; Nifedipine; Nimodipine; Rats; Rats, Wistar; Verapamil | 1996 |
NaF potentiates a K(+)-selective ion channel in G292 osteoblastic cells.
Topics: Calcium Channel Blockers; Electric Conductivity; Humans; Membrane Potentials; Nimodipine; Osteoblasts; Potassium Channels; Sodium Fluoride; Tumor Cells, Cultured; Verapamil | 1996 |
Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels.
Topics: Biguanides; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Electrophysiology; Fura-2; Granisetron; Humans; Kidney; Kinetics; Microscopy, Video; Neuroblastoma; Nimodipine; Radioligand Assay; Receptors, Serotonin; Receptors, Serotonin, 5-HT3; Serotonin Antagonists; Serotonin Receptor Agonists; Tritium; Tumor Cells, Cultured; Verapamil | 1996 |
Growth hormone regulates cytosolic free calcium in rat fat cells by maintaining L-type calcium channels.
Topics: Adipocytes; Animals; Calcium; Calcium Channels; Cycloheximide; Cytosol; Growth Hormone; Male; Manganese; Nimodipine; Rats; Rats, Inbred Strains; Verapamil | 1996 |
Effect of treatment with calcium antagonists in vitro and in vivo on the contractile response of isolated rat and human detrusor muscle.
Topics: Animals; Calcium Channel Blockers; Carbachol; Electric Stimulation; Female; Humans; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Nimodipine; Rats; Rats, Wistar; Urinary Bladder; Urination Disorders; Verapamil | 1996 |
Effects of calcium blockers on the cytosolic calcium, H2O2 production and elastase release in human neutrophils.
Topics: Calcium; Calcium Channel Blockers; Cytosol; Felodipine; Humans; Hydrogen Peroxide; Leukocyte Elastase; Neutrophil Activation; Neutrophils; Nimodipine; Verapamil | 1996 |
Modulation of melphalan and cisplatin cytotoxicity in human ovarian cancer cells resistant to alkylating drugs.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Blotting, Northern; Calcium Channel Blockers; Cell Survival; Cisplatin; Culture Media; Cystadenoma; Drug Resistance, Neoplasm; Female; Flunarizine; Humans; Melphalan; Nimodipine; Ovarian Neoplasms; RNA Probes; RNA, Neoplasm; Tumor Cells, Cultured; Verapamil | 1997 |
The effects of verapamil and nimodipine on bupivacaine-induced cardiotoxicity in rats: an in vivo and in vitro study.
Topics: Anesthetics, Local; Animals; Arrhythmias, Cardiac; Blood Pressure; Bupivacaine; Calcium Channel Blockers; Confidence Intervals; Coronary Circulation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Heart; Heart Rate; Incidence; Injections, Intravenous; Lethal Dose 50; Male; Myocardial Contraction; Nimodipine; Premedication; Rats; Rats, Sprague-Dawley; Survival Rate; Verapamil | 1998 |
Multidrug resistance transporter P-glycoprotein has distinct but interacting binding sites for cytotoxic drugs and reversing agents.
Topics: Adenosine Triphosphatases; Animals; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Calcium Channel Blockers; CHO Cells; Cricetinae; Cytotoxins; Dihydropyridines; Drug Resistance, Multiple; Fibroblasts; Nicardipine; Nimodipine; Nitrendipine; Protein Binding; Verapamil; Vinblastine | 1998 |
Effects of various Ca2+ channel antagonists on morphine analgesia, tolerance and dependence, and on blood pressure in the rat.
Topics: Analgesics, Opioid; Animals; Binding Sites; Blood Pressure; Calcium Channel Blockers; Cerebral Cortex; Drug Interactions; Drug Tolerance; Male; Morphine; Nifedipine; Nimodipine; Nitrendipine; Rats; Rats, Wistar; Substance-Related Disorders; Tritium; Verapamil | 1998 |
Structure and functional characterization of a novel human low-voltage activated calcium channel.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Amiloride; Animals; Barium; Benzimidazoles; Blotting, Northern; Cadmium; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, T-Type; Cells, Cultured; Cloning, Molecular; Diuretics; DNA, Complementary; Electric Stimulation; Electrophysiology; Humans; Ion Channel Gating; Kidney; Kinetics; Membrane Potentials; Mibefradil; Molecular Sequence Data; Nickel; Nimodipine; Oocytes; Recombinant Proteins; RNA, Messenger; Sequence Homology, Amino Acid; Tetrahydronaphthalenes; Transcription, Genetic; Verapamil; Xenopus | 1999 |
Evidence of sex related differences in the effects of calcium channel blockers on neuroleptic-induced catalepsy in mice.
Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Calcium Channel Blockers; Catalepsy; Dose-Response Relationship, Drug; Female; Flunarizine; Haloperidol; Male; Mice; Nimodipine; Sex Factors; Verapamil | 1999 |
p-Chlorobenzyltetrahydroberberine inhibits vascular smooth muscle contractions caused by Ca2+.
Topics: Animals; Aorta, Thoracic; Bepridil; Berberine; Biological Transport, Active; Calcium; Calcium Channel Blockers; Female; Hyperthyroidism; Male; Mice; Mice, Inbred ICR; Muscle Contraction; Muscle, Smooth, Vascular; Nimodipine; Rats; Rats, Sprague-Dawley; Thyroxine; Verapamil | 1998 |
Effects of calcium channel blockers on behaviors induced by the N-methyl-D-aspartate receptor antagonist, dizocilpine, in rats.
Topics: Animals; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, P-Type; Discrimination Learning; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Flunarizine; Generalization, Stimulus; Male; Motor Activity; Nimodipine; Rats; Rats, Wistar; Self Stimulation; Verapamil | 1999 |
Mechanisms through which PDGF alters intracellular calcium levels in U-1242 MG human glioma cells.
Topics: Becaplermin; Brain Neoplasms; Caffeine; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Calcium-Transporting ATPases; Elapid Venoms; Endoplasmic Reticulum; Enzyme Inhibitors; Flufenamic Acid; Glioma; Humans; Imidazoles; Ion Transport; Masoprocol; Neoplasm Proteins; Nicardipine; Nimodipine; Nitrendipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; omega-Conotoxins; Peptides; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Ryanodine; Thapsigargin; Tumor Cells, Cultured; Verapamil | 1999 |
The effects of anticancer drugs in combination with nimodipine and verapamil on cultured cells of glioblastoma multiforme.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Carmustine; Cell Division; Drug Interactions; Drug Resistance, Multiple; Drug Therapy, Combination; Glioblastoma; Humans; Immunohistochemistry; Nimodipine; Procarbazine; Tumor Cells, Cultured; Verapamil; Vincristine | 1999 |
The effects of LY393613, nimodipine and verapamil, in focal cerebral ischaemia.
Topics: Amines; Animals; Brain Ischemia; Butanes; Calcium Channel Blockers; Corpus Striatum; Dopamine; Endothelin-1; Glutamic Acid; Laser-Doppler Flowmetry; Male; Microdialysis; Nimodipine; Rats; Rats, Wistar; Time Factors; Verapamil | 2001 |
Behavioural and anti-psychotic effects of Ca2+ channel blockers in rhesus monkey.
Topics: Amphetamine; Animals; Behavior, Animal; Calcium Channel Blockers; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Nimodipine; Psychotic Disorders; Stereotyped Behavior; Verapamil | 2001 |
Potentiation of analgesia and reversal of tolerance to morphine by calcium channel blockers.
Topics: Analgesia; Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Drug Tolerance; Female; Flunarizine; Male; Mice; Morphine; Nimodipine; Pain Threshold; Verapamil | 2001 |
L-type Ca(2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Mice; Morphine; Motor Activity; Narcotic Antagonists; Narcotics; Nifedipine; Nimodipine; Verapamil | 2003 |
Functional expression of L- and T-type Ca2+ channels in murine HL-1 cells.
Topics: Animals; Calcium; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell Line; Electric Conductivity; Heart Atria; Ion Transport; Mibefradil; Mice; Myocytes, Cardiac; Nimodipine; Patch-Clamp Techniques; Pimozide; Potassium; Verapamil | 2004 |
Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice.
Topics: Analgesia; Animals; Area Under Curve; Brain; Brain Chemistry; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Nimodipine; Pain; Pain Measurement; Physical Stimulation; Tissue Distribution; Verapamil | 2004 |
L-type calcium channel blockers enhance 5-HTP-induced antinociception in mice.
Topics: 5-Hydroxytryptophan; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Chloride; Chelating Agents; Drug Synergism; Egtazic Acid; Female; Fluoxetine; Injections, Intraventricular; Mice; Motor Activity; Nifedipine; Nimodipine; Pain Measurement; Pargyline; Selective Serotonin Reuptake Inhibitors; Verapamil | 2004 |
Miniaturisation and validation of a cell-based assay for screening of Ca2+ channel modulators.
Topics: Animals; Biological Assay; Calcium; Calcium Channel Blockers; Calcium Channels; Cell Culture Techniques; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Equipment Design; Equipment Failure Analysis; Ion Channel Gating; Miniaturization; Nimodipine; Pituitary Gland; Rats; Robotics; Verapamil | 2004 |
Calcium-acting drugs modulate expression and development of chronic tolerance to nicotine-induced antinociception in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Drug Tolerance; Enzyme Activation; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Nicotine; Nicotinic Agonists; Nimodipine; Pain Measurement; Reaction Time; Spinal Cord; Verapamil | 2005 |
Inhibitory effects of L- and T-type calcium antagonists on contractions of human detrusor muscle.
Topics: Adult; Aged; Analysis of Variance; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Carbachol; Diltiazem; Female; Humans; In Vitro Techniques; Male; Mibefradil; Middle Aged; Muscle Contraction; Muscle, Smooth; Nifedipine; Nimodipine; Potassium; Urinary Bladder; Verapamil | 2006 |
Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity.
Topics: Amlodipine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Fatty Acids; Lipid Bilayers; Mice; NIH 3T3 Cells; Nimodipine; Nuclear Magnetic Resonance, Biomolecular; Thermodynamics; Verapamil | 2006 |
Protective effect of L-type calcium channel blockers against haloperidol-induced orofacial dyskinesia: a behavioural, biochemical and neurochemical study.
Topics: Animals; Antioxidants; Antipsychotic Agents; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, L-Type; Corpus Striatum; Diltiazem; Dopamine; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Movement Disorders; Nifedipine; Nimodipine; Random Allocation; Rats; Rats, Wistar; Serotonin; Verapamil | 2008 |
L-type voltage-dependent Ca(2+) channels mediate expression of presynaptic LTP in amygdala.
Topics: Amygdala; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cerebral Cortex; Conotoxins; Excitatory Postsynaptic Potentials; In Vitro Techniques; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; Neural Pathways; Neuronal Plasticity; Nickel; Nimodipine; Presynaptic Terminals; Synaptic Transmission; Verapamil | 2009 |
Trp-His, a vasorelaxant di-peptide, can inhibit extracellular Ca2+ entry to rat vascular smooth muscle cells through blockade of dihydropyridine-like L-type Ca2+ channels.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Angiotensin II; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Proliferation; Dipeptides; Male; Muscle, Smooth, Vascular; Nifedipine; Nimodipine; Rats; Rats, Wistar; Verapamil | 2010 |
Licorice-associated reversible cerebral vasoconstriction with PRES.
Topics: Administration, Oral; Brain; Cerebral Angiography; Cerebrovascular Circulation; Cerebrovascular Disorders; Female; Glycyrrhiza; Headache Disorders, Primary; Humans; Hydrocortisone; Hypertension; Magnetic Resonance Imaging; Middle Aged; Nimodipine; Posterior Leukoencephalopathy Syndrome; Seizures; Tomography, X-Ray Computed; Treatment Outcome; Vasoconstriction; Vasodilator Agents; Verapamil; Vision Disorders | 2010 |
Effects of calcium channel antagonists on the motivational effects of nicotine and morphine in conditioned place aversion paradigm.
Topics: Animals; Avoidance Learning; Calcium Channel Blockers; Drug Administration Schedule; Flunarizine; Male; Morphine; Motivation; Nicotine; Nimodipine; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Verapamil | 2012 |
Inhibition of human astrocyte and microglia neurotoxicity by calcium channel blockers.
Topics: Astrocytes; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Cells, Cultured; Chemokine CXCL11; Cytotoxicity, Immunologic; Down-Regulation; Humans; Interferon-gamma; Microglia; Molecular Targeted Therapy; Monocytes; Neurodegenerative Diseases; Neurons; Nimodipine; Phosphorylation; Protein Processing, Post-Translational; STAT3 Transcription Factor; Verapamil | 2012 |
Human cardiotoxic drugs delivered by soaking and microinjection induce cardiovascular toxicity in zebrafish.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Cardiotoxins; Clomipramine; Cyclophosphamide; Disease Models, Animal; Edema; Gentamicins; Heart Diseases; Heart Rate; Heart Ventricles; Larva; Microinjections; Nimodipine; Pericardium; Quinidine; Terfenadine; Tetracycline; Toxicity Tests; Verapamil; Yolk Sac; Zebrafish | 2014 |
Nephroprotective effect of calcium channel blockers against toxicity of lead exposure in mice.
Topics: Animals; Apoptosis; Blood Urea Nitrogen; Body Weight; Calcium Channel Blockers; Creatinine; Cytoprotection; Disease Models, Animal; Glutathione Peroxidase; Kidney; Kidney Diseases; Lead Poisoning; Lipid Peroxidation; Male; Malondialdehyde; Mice; Nimodipine; Organ Size; Organometallic Compounds; Superoxide Dismutase; Verapamil | 2013 |
Nifedipine and nimodipine protect dopaminergic substantia nigra neurons against axotomy-induced cell death in rat vibrosections via modulating inflammatory responses.
Topics: Animals; Axotomy; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Death; Cholinergic Neurons; Dopaminergic Neurons; Isradipine; Neuroimmunomodulation; Neuroprotective Agents; Nicardipine; Nifedipine; Nimodipine; Rats, Sprague-Dawley; Substantia Nigra; Tissue Culture Techniques; Ventral Tegmental Area; Verapamil | 2014 |
Characterization of cadmium plasma membrane transport in gills of a mangrove crab Ucides cordatus.
Topics: Animals; Biological Transport; Brachyura; Cadmium; Caffeine; Calcium; Calcium Channel Blockers; Cell Membrane; Cell Survival; Chelating Agents; Egtazic Acid; Fluorescence; Fluorescent Dyes; Gills; Ion Transport; Nimodipine; Vanadates; Verapamil; Water Pollutants, Chemical | 2014 |
Results of an International Survey on the Investigation and Endovascular Management of Cerebral Vasospasm and Delayed Cerebral Ischemia.
Topics: Adult; Australasia; Brain Ischemia; Disease Management; Endovascular Procedures; Europe; Female; Health Care Surveys; Humans; International Cooperation; Male; Middle Aged; Neuroradiography; Neurosurgery; Nimodipine; Practice Patterns, Physicians'; Subarachnoid Hemorrhage; Surveys and Questionnaires; Time Factors; Ultrasonography, Doppler, Transcranial; United Kingdom; United States; Vasodilator Agents; Vasospasm, Intracranial; Verapamil | 2015 |
Apoptosis induced by NAD depletion is inhibited by KN-93 in a CaMKII-independent manner.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Benzylamines; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Cytokines; Humans; Membrane Potential, Mitochondrial; Membrane Proteins; NAD; Nicotinamide Phosphoribosyltransferase; Nimodipine; Peptides; Proto-Oncogene Proteins; Sulfonamides; Verapamil | 2015 |
Calcium channel blockers ameliorate iron overload-associated hepatic fibrosis by altering iron transport and stellate cell apoptosis.
Topics: Animals; Apoptosis; Calcium Channel Blockers; Cell Line; Collagen; Deferoxamine; Diltiazem; Hepatic Stellate Cells; Iron; Iron Overload; Liver; Liver Cirrhosis; Male; Matrix Metalloproteinase 13; Mice; Nimodipine; Rats; Tissue Inhibitor of Metalloproteinase-1; Verapamil | 2016 |
Reversible Cerebral Vasoconstriction Syndrome.
Topics: Adult; Brain Infarction; Circle of Willis; Coronary Vasospasm; Female; Headache Disorders, Primary; Heparin; Humans; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Nimodipine; Platelet Aggregation Inhibitors; Treatment Outcome; Vasoconstriction; Vasospasm, Intracranial; Verapamil | 2016 |
Chemical angioplasty for medically refractory reversible cerebral vasoconstriction syndrome
Topics: Angioplasty; Calcium Channel Blockers; Drug Resistance; Female; Humans; Infusions, Intra-Arterial; Magnetic Resonance Imaging; Middle Aged; Nimodipine; Syndrome; Treatment Outcome; Vasodilator Agents; Vasospasm, Intracranial; Verapamil | 2018 |