verapamil has been researched along with morphine in 79 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (22.78) | 18.7374 |
| 1990's | 17 (21.52) | 18.2507 |
| 2000's | 26 (32.91) | 29.6817 |
| 2010's | 17 (21.52) | 24.3611 |
| 2020's | 1 (1.27) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Dagenais, C; Ducharme, J; Pollack, GM; Zong, J | 1 |
| Aimi, N; Horie, S; Ishikawa, H; Kitajima, M; Koyama, F; Kurihara, M; Matsumoto, K; Moriyama, T; Murayama, T; Ponglux, D; Takayama, H; Watanabe, K; Yamamoto, LT | 1 |
| Fischer, H; Huwyler, J; Poli, S; Schwab, D; Tabatabaei, A | 1 |
| Thakker, DR; Troutman, MD | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Nagashima, R; Nishikawa, T; Tobita, M | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Anand, JP; Fernandez, TJ; Griggs, NW; Henry, SP; Mosberg, HI; Traynor, JR | 1 |
| Huang, JT; Takemori, AE | 1 |
| Calignano, A; Capasso, A; Mancuso, F; Persico, P; Sorrentino, L | 1 |
| Bustamante, D; Fernandez, E; Kramer, V; Miranda, HF; Paeile, C; Pelissier, T; Pinardi, G; Saavedra, H | 1 |
| Kamei, J; Kasuya, Y | 1 |
| Schnur, P | 1 |
| Hollman, A | 1 |
| Baeyens, JM; Del Pozo, E; Ruiz-García, C | 1 |
| Kavaliers, M | 1 |
| Kavaliers, M; Ossenkopp, KP | 1 |
| Baeyens, JM; Barrios, M | 1 |
| Cone, E; Della Puppa, A; Ford-Rice, F; London, ED; Snyder, FR | 1 |
| Diener, M; Knobloch, SF; Rummel, W | 1 |
| Dikshit, RK; Mansuri, SM; Shah, MH | 1 |
| Bongianni, F; Carla, V; Moroni, F; Pellegrini-Giampietro, DE | 1 |
| London, ED; Snyder, FR; Szikszay, M | 2 |
| Brase, DA; Dewey, WL; Lux, F; Welch, SP | 1 |
| Brasch, H | 1 |
| Filias, N | 1 |
| Borowitz, JL; Kuta, CC; Maickel, RP | 1 |
| Benjamin, GC | 1 |
| Benedek, G; Szikszay, M | 1 |
| Maroko, PR | 1 |
| Martinez-Piñero, MG; Milanés, MV; Vargas, ML | 1 |
| Iwasaki, H; Kawamata, M; Namiki, A; Omote, K; Sonoda, H | 1 |
| Lange, WR; London, ED; Vaupel, DB | 1 |
| Görgün, CZ; Güney, HZ; Güzey, C; Hodoğluğil, U; Savran, B; Zengil, H | 1 |
| Contreras, E; Germany, A; Gonzalez, P; Norris, B | 1 |
| Hasegawa, AE; Zacny, JP | 1 |
| Almeida, OF; Deicke, J; Fischer, D; Gärtner, P; Hassan, AH; Hellbach, S | 1 |
| Choe, H; Han, YJ; Kim, DC; Kim, JS; Ko, SH; Song, HS | 1 |
| Abdollahi, M; Etemad, F; Nikfar, S; Sarkarati, F | 1 |
| Antkiewicz-Michaluk, L; Karolewicz, B; Michaluk, J; Vetulani, J | 1 |
| Doğrul, A; Yeşilyurt, O | 1 |
| Doherty, MM; Pang, KS | 1 |
| Blackburn-Munro, G; Brown, CH; Landgraf, R; Neumann, ID; Russell, JA | 1 |
| Reuben, JP; Reuben, SS | 1 |
| Pollack, GM; Zong, J | 1 |
| Brodacz, B; Holzer-Petsche, U; Horváth, G | 2 |
| Crowe, A | 1 |
| Mediratta, PK; Sharma, KK; Verma, V | 1 |
| Li, JX; Liang, JH; Liu, RK; Zhang, Q; Zheng, JW | 1 |
| Liang, JH; Lu, Y; Ye, XF; Zhang, P | 1 |
| Fukazawa, Y; Kishioka, S; Maeda, T; Ozaki, M; Shimizu, N; Yamamoto, C; Yamamoto, H | 1 |
| Dake, Y; Fukazawa, Y; Kishioka, S; Maeda, T; Ozaki, M; Shimizu, N; Yamamoto, C; Yamamoto, H | 1 |
| Cisternino, S; Debray, M; Rousselle, C; Scherrmann, JM | 1 |
| Drewe, J; Fux, I; Gutmann, H; Kusch-Poddar, M | 1 |
| Hawkins, BT; Miller, DS; Sykes, DB | 1 |
| Amanallahi, F; Dabiri, S; Esmaeili-Mahani, S; Ghotbi, P; Joukar, F; Joukar, S; Najafipour, H; Sheibani, V | 1 |
| Biala, G; Budzynska, B; Polak, P | 1 |
| Amini, N; Farde, L; Finnema, SJ; Halldin, C; Lundquist, S; Nakao, R; Schou, M; Takano, A; Varnäs, K | 1 |
| Asadi, S; Nojavan, S; Parsa, M; Tabani, H | 1 |
| Biala, G; Budzynska, B; Kruk-Slomka, M; Michalak, A; Pekala, K | 1 |
| Guo, D; Guo, J; Huang, S; Li, Q; Polli, JE; Shu, Y; Xiong, Z; Ye, Z; Zhang, W; Zhou, H; Zhu, P | 1 |
| Du, W; Duan, Y; Jin, L; Liang, J; Meng, Y; Shen, F; Sui, N; Zhang, J | 1 |
1 review(s) available for verapamil and morphine
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
4 trial(s) available for verapamil and morphine
| Article | Year |
|---|---|
Effects of verapamil on morphine-induced euphoria, analgesia and respiratory depression in humans.
Topics: Adult; Analgesia; Cardiovascular System; Drug Synergism; Euphoria; Humans; Male; Morphine; Pupil; Respiration Disorders; Verapamil | 1993 |
The influence of three L-type calcium channel blockers on morphine effects in healthy volunteers.
Topics: Adjuvants, Anesthesia; Adult; Affect; Analgesics, Opioid; Calcium Channel Blockers; Cross-Over Studies; Diltiazem; Double-Blind Method; Female; Humans; Male; Morphine; Nimodipine; Pain Threshold; Psychomotor Performance; Reference Values; Verapamil | 1997 |
Epidural verapamil reduces analgesic consumption after lower abdominal surgery.
Topics: Abdomen; Adult; Affect; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics; Analgesics, Opioid; Analysis of Variance; Anesthetics, Local; Bupivacaine; Calcium Channel Blockers; Chi-Square Distribution; Consciousness; Double-Blind Method; Follow-Up Studies; Humans; Incidence; Injections, Epidural; Middle Aged; Morphine; Pain, Postoperative; Premedication; Sensation; Sodium Chloride; Spinal Cord; Verapamil | 1998 |
Brachial plexus anesthesia with verapamil and/or morphine.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Anesthetics, Local; Calcium Channel Blockers; Double-Blind Method; Female; Humans; Lidocaine; Male; Middle Aged; Morphine; Nerve Block; Orthopedics; Pain Measurement; Verapamil | 2000 |
74 other study(ies) available for verapamil and morphine
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Effect of mdr1a P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds.
Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Knockout; Morphine; Narcotics; Perfusion; Quinidine; Sex Characteristics; Substrate Specificity; Verapamil | 2001 |
Studies on the synthesis and opioid agonistic activities of mitragynine-related indole alkaloids: discovery of opioid agonists structurally different from other opioid ligands.
Topics: Analgesics; Animals; Brain; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indole Alkaloids; Ligands; Mice; Models, Molecular; Morphine; Muscle Contraction; Muscle, Smooth; Radioligand Assay; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Secologanin Tryptamine Alkaloids; Structure-Activity Relationship | 2002 |
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Drug Evaluation, Preclinical; Fluoresceins; Fluorescent Dyes; Humans; Indicators and Reagents; Mice; Models, Molecular; Rhodamines; Species Specificity; Swine | 2003 |
Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blotting, Western; Cells, Cultured; Diffusion; Humans; Intestinal Absorption; Intestinal Mucosa; Models, Biological; Permeability; Pharmaceutical Preparations; Pharmacokinetics | 2003 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2005 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability.
Topics: Analgesics, Opioid; Animals; Drug Design; Mice; Microsomes, Liver; Morphine; Peptidomimetics; Quinolines; Receptors, Opioid, delta; Receptors, Opioid, mu; Structure-Activity Relationship | 2019 |
Accumulation of methadone by the choroid plexus in vitro.
Topics: Animals; Antimetabolites; Biological Transport; Calcium; Choroid Plexus; In Vitro Techniques; Magnesium; Male; Methadone; Morphine; Narcotic Antagonists; Phosphates; Rabbits; Time Factors; Verapamil | 1975 |
Dexamethasone modifies morphine-, atropine-, verapamil-induced constipation in mice.
Topics: Animals; Atropine; Constipation; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Male; Mice; Morphine; Verapamil | 1992 |
Antinociceptive effects of Ca2+ channel blockers.
Topics: Analgesics; Analysis of Variance; Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Mice; Morphine; Nifedipine; Nimodipine; Pain Measurement; Rats; Rats, Wistar; Verapamil | 1992 |
Antitussive effects of Ca2+ channel antagonists.
Topics: Animals; Antitussive Agents; Calcium Channel Blockers; Capsaicin; Codeine; Cough; Dextromethorphan; Drug Interactions; Drug Synergism; Flunarizine; Guinea Pigs; Male; Morphine; Nifedipine; Verapamil | 1992 |
Morphine withdrawal in the hamster.
Topics: Animals; Clonidine; Cricetinae; Morphine; Naloxone; Nifedipine; Stereotyped Behavior; Substance Withdrawal Syndrome; Verapamil | 1992 |
Verapamil and morphine.
Topics: Cardiology; History, 19th Century; History, 20th Century; Humans; Morphine; Papaver; Plants, Medicinal; Verapamil | 1991 |
Analgesic effects of diltiazem and verapamil after central and peripheral administration in the hot-plate test.
Topics: Analgesics; Animals; Diltiazem; Drug Synergism; Female; Injections, Intraventricular; Injections, Subcutaneous; Mice; Morphine; Reaction Time; Verapamil | 1990 |
Calcium channel blockers inhibit the antagonistic effects of Phe-Met-Arg-Phe-amide (FMRFamide) on morphine- and stress-induced analgesia in mice.
Topics: Animals; Calcium; Drug Interactions; FMRFamide; Ion Channels; Mice; Morphine; Nervous System; Neuropeptides; Nifedipine; Pain; Stress, Physiological; Verapamil | 1987 |
Magnetic fields inhibit opioid-mediated 'analgesic' behaviours of the terrestrial snail, Cepaea nemoralis.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics; Animals; Calcium; Diltiazem; Ion Channels; Magnetics; Morphine; Naloxone; Nifedipine; Nociceptors; Pyrrolidines; Snails; Temperature; Verapamil | 1988 |
Differential effects of calcium channel blockers and stimulants on morphine withdrawal in vitro.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Blockers; Calcium Channels; Diltiazem; Ethanol; Female; In Vitro Techniques; Morphine; Muscle Contraction; Muscle, Smooth, Vascular; Naloxone; Rats; Rats, Inbred Strains; Stereoisomerism; Substance Withdrawal Syndrome; Verapamil | 1988 |
Time course of verapamil interaction with morphine effects on physiological parameters in rats.
Topics: Animals; Blood Pressure; Carbon Dioxide; Drug Interactions; Heart Rate; Male; Morphine; Oxygen Consumption; Rats; Rats, Inbred F344; Time Factors; Verapamil | 1989 |
Action of loperamide on neuronally mediated and Ca2+- or cAMP-mediated secretion in rat colon.
Topics: Animals; Calcium; Carbachol; Colforsin; Colon; Cyclic AMP; Electric Stimulation; In Vitro Techniques; Intestinal Mucosa; Loperamide; Male; Morphine; Neurons; Piperidines; Rats; Rats, Inbred Strains; Trifluoperazine; Verapamil | 1988 |
The calcium channel antagonist, verapamil, potentiates the inhibitory action of morphine on intestinal and biliary motility.
Topics: Animals; Biliary Tract; Charcoal; Female; Gallbladder; Gastrointestinal Motility; Male; Mice; Morphine; Verapamil | 1987 |
Calcium channel inhibitors suppress the morphine-withdrawal syndrome in rats.
Topics: Animals; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Methoxyhydroxyphenylglycol; Morphine; Morphine Dependence; Naloxone; Nicotinic Acids; Nimodipine; Norepinephrine; Rats; Receptors, Opioid; Substance Withdrawal Syndrome; Verapamil | 1986 |
Effects of morphine and calcium antagonists on plasma glucose in male rats.
Topics: Animals; Blood Glucose; Drug Interactions; Kinetics; Male; Morphine; Rats; Rats, Inbred F344; Verapamil | 1986 |
Interaction of morphine with intrathecally administered calcium and calcium antagonists: evidence for supraspinal endogenous opioid mediation of intrathecal calcium-induced antinociception in mice.
Topics: Analgesics; Animals; Calcium; Egtazic Acid; Injections, Intraperitoneal; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Morphine; Naloxone; Verapamil | 1988 |
Interactions between verapamil and morphine on physiological parameters in rats.
Topics: Analysis of Variance; Animals; Biological Assay; Blood Gas Analysis; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Hydrogen-Ion Concentration; Male; Morphine; Rats; Rats, Inbred F344; Verapamil | 1986 |
Influence of the optical isomers (+)- and (-)-naloxone on beating frequency, contractile force and action potentials of guinea-pig isolated cardiac preparations.
Topics: Action Potentials; Animals; Depression, Chemical; Electric Stimulation; Guinea Pigs; Heart Atria; Heart Rate; Isomerism; Male; Membrane Potentials; Morphine; Myocardial Contraction; Naloxone; Potassium; Verapamil | 1986 |
[Some suggestions for the treatment of myocardial infarct in the pre-hospitalization phase].
Topics: Allied Health Personnel; Ambulances; Angina Pectoris; Arrhythmias, Cardiac; Atropine; Droperidol; Health Education; Heart Arrest; Humans; Lidocaine; Metaproterenol; Morphine; Myocardial Infarction; Shock, Cardiogenic; Time Factors; Verapamil; Vomiting | 1973 |
Modification of drug action by hyperammonemia.
Topics: Acetates; Ammonia; Amphetamine; Animals; Calcium; Cattle; Diltiazem; Drug Interactions; Guinea Pigs; Ileum; Ion Channels; Male; Mice; Morphine; Motor Activity; Muscle Contraction; Verapamil | 1984 |
Cardiogenic pulmonary edema.
Topics: Aminophylline; Cardiovascular Agents; Digoxin; Diuretics; Dobutamine; Dopamine; Heart Failure; Humans; Morphine; Nitroglycerin; Nitroprusside; Pulmonary Edema; Verapamil | 1984 |
Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists.
Topics: Analgesics; Animals; Body Temperature Regulation; Calcium Channel Blockers; Diltiazem; Drug Synergism; Male; Morphine; Nociceptors; Rats; Rats, Inbred Strains; Verapamil | 1984 |
Experimental infarction studies.
Topics: Animals; Chlorpromazine; Dogs; Heart Rate; Ibuprofen; Morphine; Myocardial Infarction; Myocardium; Propranolol; Time Factors; Verapamil | 1980 |
L-type Ca2+ channel ligands modulate morphine effects on the hypothalamus-pituitary-adrenocortical axis in rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Corticosterone; Dopamine; Drug Synergism; Hypothalamo-Hypophyseal System; Male; Morphine; Neurosecretory Systems; Nimodipine; Norepinephrine; Pituitary-Adrenal System; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Verapamil | 1993 |
Potentiation of antinociceptive effects of morphine by calcium-channel blockers at the level of the spinal cord.
Topics: Animals; Calcium Channel Blockers; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Injections, Spinal; Male; Morphine; Nicardipine; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord; Verapamil | 1993 |
Temporal variation in the interaction between calcium channel blockers and morphine-induced analgesia.
Topics: Analgesia; Animals; Calcium Channel Blockers; Circadian Rhythm; Diltiazem; Drug Synergism; Male; Mice; Mice, Inbred BALB C; Morphine; Nicardipine; Pain; Verapamil | 1996 |
Influence of opiate tolerance and calcium channel antagonists on the antinociceptive effects of L-arginine and NG-nitro L-arginine.
Topics: Analgesia; Analgesics, Opioid; Animals; Arginine; Calcium Channel Blockers; Diltiazem; Drug Tolerance; Enzyme Inhibitors; Male; Mice; Morphine; Nitric Oxide Synthase; Nitroarginine; Pain Measurement; Pentazocine; Verapamil | 1997 |
Inherent glucocorticoid response potential of isolated hypothalamic neuroendocrine neurons.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Arginine Vasopressin; beta-Endorphin; Calcium; Cells, Cultured; Coculture Techniques; Corticotropin-Releasing Hormone; Culture Media, Serum-Free; Dexamethasone; Glucocorticoids; Kinetics; Male; Mifepristone; Morphine; Naloxone; Neurons; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Sodium; Tetrodotoxin; Verapamil; Veratridine | 1998 |
Interaction between calcium channel blockers and sweetening agents on morphine-induced analgesia in mice by formalin test.
Topics: Analgesics; Animals; Aspartame; Calcium Channel Blockers; Diltiazem; Drug Interactions; Male; Mice; Morphine; Nifedipine; Pain Measurement; Saccharin; Sucrose; Sweetening Agents; Verapamil | 1998 |
Effects of various Ca2+ channel antagonists on morphine analgesia, tolerance and dependence, and on blood pressure in the rat.
Topics: Analgesics, Opioid; Animals; Binding Sites; Blood Pressure; Calcium Channel Blockers; Cerebral Cortex; Drug Interactions; Drug Tolerance; Male; Morphine; Nifedipine; Nimodipine; Nitrendipine; Rats; Rats, Wistar; Substance-Related Disorders; Tritium; Verapamil | 1998 |
Effects of Ca2+ channel blockers on apomorphine, bromocriptine and morphine-induced locomotor activity in mice.
Topics: Amlodipine; Animals; Apomorphine; Benzazepines; Bromocriptine; Calcium Channel Blockers; Diltiazem; Dopamine Antagonists; Female; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Mice; Morphine; Motor Activity; Nicardipine; Time Factors; Verapamil | 1999 |
Route-dependent metabolism of morphine in the vascularly perfused rat small intestine preparation.
Topics: Animals; Calcium Channel Blockers; Duodenum; Injections, Intra-Arterial; Intestinal Absorption; Male; Microsomes; Models, Biological; Morphine; Narcotics; Organ Culture Techniques; Perfusion; Rats; Rats, Sprague-Dawley; Tritium; Verapamil | 2000 |
Verapamil prevents withdrawal excitation of oxytocin neurones in morphine-dependent rats.
Topics: Animals; Animals, Suckling; Calcium Channel Blockers; Calcium Channels, L-Type; Electric Stimulation; Female; Hypertonic Solutions; Injections, Intraventricular; Lactation; Membrane Potentials; Microdialysis; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Neurons; Oxytocin; Pituitary Gland; Rats; Rats, Sprague-Dawley; Sincalide; Substance Withdrawal Syndrome; Succinimides; Supraoptic Nucleus; Verapamil | 2000 |
Morphine antinociception is enhanced in mdr1a gene-deficient mice.
Topics: Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Male; Mice; Mice, Knockout; Morphine; Verapamil | 2000 |
Role of calcium channels in the spinal transmission of nociceptive information from the mesentery.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, N-Type; Clonidine; Dose-Response Relationship, Drug; Female; Mesentery; Morphine; omega-Conotoxins; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Synaptic Transmission; Verapamil | 2001 |
The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel.
Topics: Analgesics, Opioid; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buthionine Sulfoximine; Caco-2 Cells; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Genistein; Glutathione; Humans; Indomethacin; Morphine; Paclitaxel; Probenecid; Progesterone; Time Factors; Verapamil | 2002 |
Potentiation of analgesia and reversal of tolerance to morphine by calcium channel blockers.
Topics: Analgesia; Animals; Calcium Channel Blockers; Diltiazem; Drug Interactions; Drug Tolerance; Female; Flunarizine; Male; Mice; Morphine; Nimodipine; Pain Threshold; Verapamil | 2001 |
Blood pressure changes after intrathecal co-administration of calcium channel blockers with morphine or clonidine at the spinal level.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Injections, Spinal; Morphine; omega-Conotoxins; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Spinal Cord; Verapamil | 2002 |
L-type Ca(2+) channel blockers inhibit the development but not the expression of sensitization to morphine in mice.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Mice; Morphine; Motor Activity; Narcotic Antagonists; Narcotics; Nifedipine; Nimodipine; Verapamil | 2003 |
Calmodulin inhibitor trifluoperazine attenuates the development and expression of morphine-induced conditioned place preference in rats.
Topics: Animals; Apomorphine; Calcium Channel Blockers; Calmodulin; Conditioning, Psychological; Dopamine D2 Receptor Antagonists; Dose-Response Relationship, Drug; Male; Morphine; Motor Activity; Narcotics; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Trifluoperazine; Verapamil | 2004 |
Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice.
Topics: Analgesia; Animals; Area Under Curve; Brain; Brain Chemistry; Calcium Channel Blockers; Calcium Channels, L-Type; Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Nimodipine; Pain; Pain Measurement; Physical Stimulation; Tissue Distribution; Verapamil | 2004 |
Involvement of peripheral mechanism in the verapamil-induced potentiation of morphine analgesia in mice.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Corticosterone; Dose-Response Relationship, Drug; Drug Synergism; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; Morphine; Motor Activity; Naloxone; Pain Measurement; Quaternary Ammonium Compounds; Receptors, Opioid, mu; Verapamil | 2004 |
In situ transport of vinblastine and selected P-glycoprotein substrates: implications for drug-drug interactions at the mouse blood-brain barrier.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Colchicine; Cyclosporins; Dexamethasone; Drug Interactions; Male; Mice; Mice, Inbred Strains; Morphine; Progesterone; Quinidine; Verapamil; Vinblastine | 2004 |
Evaluation of the immortalized human brain capillary endothelial cell line BB19 as a human cell culture model for the blood-brain barrier.
Topics: Adrenergic beta-Antagonists; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport, Active; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Capillary Permeability; Cell Culture Techniques; Cell Line; Cells, Cultured; Daunorubicin; Endothelium, Vascular; Humans; Models, Biological; Morphine; Narcotics; Propranolol; Sucrose; Swine; Verapamil | 2005 |
Rapid, reversible modulation of blood-brain barrier P-glycoprotein transport activity by vascular endothelial growth factor.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Blood-Brain Barrier; Brain; Capillaries; Caveolin 1; Cerebral Arteries; Down-Regulation; Enzyme Inhibitors; Injections, Intraventricular; Male; Microcirculation; Morphine; Pyrimidines; Rats; Rats, Sprague-Dawley; Signal Transduction; src-Family Kinases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2; Verapamil | 2010 |
The effect of chronic co-administration of morphine and verapamil on isoproterenol-induced heart injury.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Drug Synergism; Heart; Heart Injuries; Isoproterenol; Male; Morphine; Myocardium; Narcotics; Rats; Rats, Wistar; Troponin I; Verapamil | 2011 |
Effects of calcium channel antagonists on the motivational effects of nicotine and morphine in conditioned place aversion paradigm.
Topics: Animals; Avoidance Learning; Calcium Channel Blockers; Drug Administration Schedule; Flunarizine; Male; Morphine; Motivation; Nicotine; Nimodipine; Rats; Rats, Wistar; Substance Withdrawal Syndrome; Verapamil | 2012 |
Large Variation in Brain Exposure of Reference CNS Drugs: a PET Study in Nonhuman Primates.
Topics: Animals; Brain; Carbon Radioisotopes; Central Nervous System Agents; Dose-Response Relationship, Drug; Female; Macaca fascicularis; Macaca mulatta; Models, Biological; Models, Chemical; Morphine; Positron-Emission Tomography; Radiopharmaceuticals; Sulpiride; Verapamil | 2015 |
Introduction of agarose gel as a green membrane in electromembrane extraction: An efficient procedure for the extraction of basic drugs with a wide range of polarities.
Topics: Amlodipine; Electricity; Green Chemistry Technology; Hydrogen-Ion Concentration; Limit of Detection; Membranes, Artificial; Morphine; Rivastigmine; Sepharose; Verapamil; Wastewater | 2017 |
The role of verapamil and SL-327 in morphine- and ethanol-induced state-dependent and cross state-dependent memory.
Topics: Aminoacetonitrile; Animals; Behavior, Addictive; Cognition; Ethanol; Male; Memory; Mice; Morphine; Verapamil | 2018 |
Irinotecan Alters the Disposition of Morphine Via Inhibition of Organic Cation Transporter 1 (OCT1) and 2 (OCT2).
Topics: Amitriptyline; Animals; Drug Interactions; Fluoxetine; HEK293 Cells; Humans; Imipramine; Irinotecan; Mice, Inbred C57BL; Morphine; Narcotics; Ondansetron; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Tissue Distribution; Verapamil | 2018 |
Distinctive roles of L-type calcium channels subtypes within the dorsal hippocampus in formation of morphine withdrawal-induced aversion in rats.
Topics: Animals; Avoidance Learning; Calcium Channels, L-Type; Hippocampus; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Rats; Substance Withdrawal Syndrome; Verapamil | 2023 |