verapamil has been researched along with metoprolol in 180 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (22.78) | 18.7374 |
| 1990's | 35 (19.44) | 18.2507 |
| 2000's | 54 (30.00) | 29.6817 |
| 2010's | 43 (23.89) | 24.3611 |
| 2020's | 7 (3.89) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Lüllmann, H; Timmermans, PB; Weikert, GM; Ziegler, A | 1 |
| Gubernator, K; Kansy, M; Senner, F | 1 |
| Danelian, E; Hämäläinen, MD; Hansson, A; Karlén, A; Karlsson, R; Lennernäs, H; Löfâs, S; Winiwarter, S | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Hwang, KK; Mandagere, AK; Thompson, TN | 1 |
| Pajeva, IK; Wiese, M | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Brockhoff, PB; Christensen, MS; Guldbrandt, M; Jensen, BF; Padkjaer, SB; Refsgaard, HH | 1 |
| Caron, G; Ermondi, G | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Akamatsu, M; Fujikawa, M; Nakao, K; Shimizu, R | 1 |
| Abraham, MH; Acree, WE; Ibrahim, A | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahman, M; Holmén, AG; Wan, H | 1 |
| Bard, B; Carrupt, PA; Martel, S | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Avdeef, A; Tam, KY | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Akamatsu, M | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Bode, ML; Gravestock, D; Hoppe, HC; Khan, T; Moleele, SS; Nkabinde, LA; Pelly, SC; Steenkamp, PA; van der Westhuyzen, CW | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Barber, S; Dew, TP; Farrell, TL; Poquet, L; Williamson, G | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Antonov, L; Gastreich, M; Hristova, S; Neumann, B; Stammler, HG; Tzvetkov, NT | 1 |
| Albert, DH; Bui, MH; Edalji, RP; Elmore, SW; Faivre, EJ; Fang, G; Fidanze, SD; Gao, W; Hasvold, LA; Huang, X; Hutchins, CW; Kati, WM; Li, L; Lin, X; Liu, D; Magoc, TJ; Mantei, RA; Martin, R; McDaniel, KF; Park, CH; Pratt, JK; Rajaraman, G; Shen, JJ; Shen, Y; Sheppard, GS; Soltwedel, T; Sun, CC; Wang, L; Wang, R; Warder, SE; Wilcox, D; Wong, S | 1 |
| Bauer, D; Fischer, S; Greif, D; Hauser, C; Hauser, S; Jäckel, E; Lohse, M; Löser, R; Ludwig, FA; Pietsch, M; Pietzsch, J; Pisabarro, MT; Pufe, J; Ruiz-Gómez, G; Wodtke, R; Wong, A | 1 |
| Cleghorn, LAT; Davis, S; Epemolu, O; Ferguson, L; Green, SR; Guijarro, L; Hipskind, P; Huggett, M; Korkegian, A; Kumar, A; Lopez Moure, A; Masquelin, T; Odingo, J; Parish, T; Ray, PC; Read, KD; Riley, J; Rullas, J; Scullion, P; Shishikura, Y; Smith, A; Turner, P; Wescott, H; Wilson, C; Wyatt, PG; Zuccotto, F | 1 |
| Bukhari, S; Cabral, AD; de Araujo, ED; Gawel, JM; Gunning, PT; He, L; Johns, AE; Manaswiyoungkul, P; Nawar, N; Olaoye, OO; Raouf, YS; Sedighi, A; Shouksmith, AE; Sina, D | 1 |
| Guo, HF; Jin, J; Li, ZR; Liu, ZY; Xie, ZS; Xue, ST; Yi, H; Zhang, L | 1 |
| Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S | 1 |
| Ahuja, VT; Allen, J; Bristow, LJ; Bronson, JJ; Brown, JM; Camac, D; Dandapani, K; Dokania, M; Dzierba, CD; Easton, A; Elavazhagan, S; Gulianello, M; Hamman, BD; Hartz, RA; Hunihan, L; Kiefer, SE; Kostich, W; Kumar, CMV; Lewis, M; Lippy, JS; Macor, JE; Muckelbauer, JK; Nara, SJ; Pattipati, SN; Rajamani, R; Surti, N | 1 |
| Csapo, G | 1 |
| Federman, J; Vlietstra, RE | 1 |
| Lydtin, H; Trenkwalder, P | 1 |
| Durel, LA; Hayashi, PJ; Schneiderman, N; Weidler, DJ | 1 |
| Hiraoka, I; Oka, H; Oshita, S; Takeshita, H | 1 |
| Seesko, RC; Zimmer, HG | 1 |
| Haunsø, S; Sejrsen, P; Svendsen, JH | 1 |
| Bailey, DG; Carruthers, SG | 1 |
| Kanai, T; Kasajima, T; Nishikawa, T | 1 |
| Doggrell, SA | 1 |
| Das, UN; Koratkar, R; Prabha, PS; Ramesh, G; Sagar, PS | 1 |
| Anderson, NM; Cruickshank, JK; Jepson, E; Wadsworth, J; Young, SM | 2 |
| Lortet, S; Zimmer, HG | 1 |
| Metelitsa, VI | 1 |
| Ahuja, RC; Hasan, M; Jain, AK; Saran, RK; Sinha, N | 1 |
| McGourty, JC; Silas, JH; Solomon, SA | 1 |
| Yusuf, S | 1 |
| Arsura, E; Lefkin, AS; Scher, DL; Solar, M; Tessler, S | 1 |
| Marschner, G; Zierhut, W; Zimmer, HG | 1 |
| Cocco, C; Franceschini, L; Menegatti, G; Nidasio, GP; Rizzotti, P; Vassanelli, C | 1 |
| Geller, M; Kirch, W; Mönig, H; Ohnhaus, EE; Santos, SR; Stenzel, J | 1 |
| Gülker, H; Haverkamp, W; Hindricks, G; Thale, J | 1 |
| Harper, RW; Harrison, PM; Keech, AC; McLean, AJ; Pitt, A | 1 |
| Forsyth, D; Frais, MA; Hussain, M; Nelson, GI; Silke, B; Taylor, SH; Verma, SP | 1 |
| Bilsker, M; Castellanos, A; Myerburg, RJ; Stafford, WJ; Trohman, RG; Zaman, L | 1 |
| Bengtsson, B; Edgar, B; Raner, S; Rönn, O | 1 |
| Gaba, DM; Maze, M; Metz, S | 1 |
| Harper, RW; Harrison, PM; Knight, R; McLean, AJ | 1 |
| Aliperta, A; Catena, E; Giordano, L; Lampa, E; Marmo, E; Perna, D; Rossi, F | 1 |
| Weidinger, H | 1 |
| Bernauer, W | 1 |
| Anderson, ST; Federman, J; Harper, RW; Laufer, E; Pitt, A; Wayne, VS | 1 |
| Fitzsimons, TJ; Holt, D; Johnston, A; Warrington, SJ | 1 |
| Hess, DS; Scheinman, MM | 1 |
| Hyldstrup, L; Mogensen, NB; Nielsen, PE | 1 |
| Hugenholtz, PG; Michels, R; Serruys, PW; Simoons, ML | 1 |
| Blumlein, SL; Kidd, P; Parmley, WW; Sievers, R | 1 |
| Eisenberg, JN; Oakley, GD | 1 |
| Burgersdijk, C; van der Meer, FJ; van der Vijver, JC | 1 |
| Downey, JM; Hearse, DJ; Yellon, DM | 1 |
| Bilgin, Y; Gigler, G; Maier, WD; Neuss, H; Schlepper, M; Thormann, J | 1 |
| Candau, LA; Pereira, LS; Scherr, C | 1 |
| Efsen, F; Sandøe, E; Vilhelmsen, R | 1 |
| Arnman, K; Rydén, L | 1 |
| de Oliveira, JM | 1 |
| Gorlin, R; Guererro, J; Holt, J; McAllister, RG; Medina, N; Meller, J; Packer, M; Smith, H; Todd, GD; Yushak, M | 1 |
| Chequer, CV; Fernandes, EO; Latreca, CE; Reis, NB; Talberg, J | 1 |
| Carlsson, B; Drvota, V; Häggblad, J; Sylvén, C | 1 |
| Rehnqvist, N | 1 |
| De Clerck, F; Lu, HR; Remeysen, P | 1 |
| Mautz, DS; Nelson, WL; Shen, DD | 1 |
| Cohan, B; Lee, DW | 1 |
| Held, C; Hjemdahl, P; Rehnqvist, N; Wallén, NH | 1 |
| Billing, E; Björkander, I; Eriksson, SV; Forslund, L; Held, C; Hjemdahl, P; Rehnqvist, N; Wallén, H | 1 |
| Goodman, S; Langer, A; Mironov, D; Morgan, CD; Singh, N | 1 |
| Billing, E; Björkander, I; Eriksson, SV; Forslund, L; Held, C; Hjemdahl, P; Näsman, P; Rehnqvist, N; Wallén, NH | 1 |
| Goel, P; Jhamb, DK; Kaul, U; Sharda, B; Singh, B; Talwar, KK; Wasir, HS | 1 |
| Allen, LV; Erickson, MA | 1 |
| Howard, DC | 1 |
| Gonsorcík, J; Mydlík, M; Palko, S; Szakács, M | 1 |
| Fraudeau, C; Luck, G; Mangani, F; Vérette, E | 1 |
| Björkander, I; Eriksson, SV; Forslund, L; Held, C; Hjemdahl, P; Rehnqvist, N; Wallén, NH; Wiman, B | 1 |
| Billing, E; Hjemdahl, P; Rehnqvist, N | 1 |
| Friedman, BJ; Grinberg, OY; Grinberg, SA; Swartz, HM | 1 |
| Angelin, B; Berglund, L; Björkander, I; Brodin, U; Forslund, L; Held, C; Hjemdahl, P; Rehnqvist, N | 1 |
| Bossi, M; Tiberti, G | 1 |
| Bartoli, P; Bonechi, F; Brandinelli, A; Del Rosso, A; Fradella, G; Ieri, A; Maioli, M; Mannelli, M; Mazza, F; Russo, L; Sansoni, M; Zipoli, A | 1 |
| Behnke, B; Gebhardt, A; Naegele, H; Strohbeck, M | 1 |
| Belz, GG; Breithaupt-Grögler, K; Gerhardt, G; Lehmann, G; Notter, T | 1 |
| Alanoğlu, Z; Göktug, A; Tulunay, M; Yörükoğlu, D | 1 |
| Björkander, I; Eriksson, SV; Forslund, L; Held, C; Hjemdahl, P; Rehnqvist, N | 2 |
| Björkander, I; Forslund, L; Håkan Wallén, N; Held, C; Hjemdahl, P; Rehnqvist, N; Wiman, B | 1 |
| Gordeladze, JO; Jynge, P; Sellevold, OF | 1 |
| Björkander, I; Brodin, U; Eriksson, SV; Forslund, L; Held, C; Hjemdahl, P; Rehnqvist, N | 1 |
| Bauer, LA; Easterling, TR; Horn, JR; Maxon, MS; Shen, DD; Strandness, DE | 1 |
| Lei, Z; Liu, Z; Ni, J; Wu, R; Ye, M; Zou, H | 1 |
| Björkander, I; Ericson, M; Forslund, L; Held, C; Hjemdahl, P; Kahan, T; Rehnqvist, N | 2 |
| Caracciolo, VJ; Charney, P; Shaefer, BM | 1 |
| Boon, D; Huijskes, R; Piek, JJ; van Goudoever, J; van Montfrans, GA | 1 |
| Bertaglia, E; D'Este, D; Michieletto, M; Pascotto, P; Zerbo, F | 1 |
| Aoki, S; Arao, T; Fuke, C; Hishida, S; Kamamoto, T; Kinoshita, H; Komeda, M; Kubota, A; Minami, T; Miyazaki, T; Motomura, H; Nishiguchi, M; Ohta, T; Ouchi, H; Taniguchi, T; Tsuda, T; Utsumi, T | 1 |
| Reyes, JL; Rosas-L, E; Villegas-Navarro, A | 1 |
| Bass, EB; Tamariz, LJ | 1 |
| Atwell, R; Brown, L; Campbell, F; Fenning, A; Hoey, A | 1 |
| Harju, K; Ketola, RA; Kostiainen, R; Kotiaho, T; Salo, PK; Salomies, H; Yli-Kauhaluoma, J | 1 |
| Eriksson, SV; Forslund, L; Held, C; Hjemdahl, P; Näsman, P; Rehnqvist, N | 1 |
| Björkander, I; Forslund, L; Held, C; Hjemdahl, P; Rehnqvist, N | 1 |
| Balimane, P; Kadiyala, P; Olah, T; Smalley, J; Xin, B | 1 |
| Antopolsky, M; Chajek-Shaul, T; Hasin, T; Leibowitz, D | 1 |
| Burke, MC; Jacobs, A; Knight, BP; McDonald, KT | 1 |
| Hii, JT; Horowitz, JD; Ritchie, RH; Wuttke, RD; Zeitz, CJ | 1 |
| Blagova, OV; Nedostup, AV | 1 |
| Cai, Y; Jia, J; Li, S; Liu, G; Liu, Y; Pan, C; Ren, J; Yu, C | 1 |
| Almquist, T; Forslund, L; Hjemdahl, P; Rehnqvist, N | 1 |
| Galkin, A; Heinonen, M; Kreander, K; Laitinen, L; Tammela, P; Vuorela, P; Vuorela, S | 1 |
| Iwao, H; Kito, G; Kuwano, K; Nagata, R; Shimomoto, M; Tamai, A; Tsusaki, H; Yonamine, H | 1 |
| Grimm, E; Herrmann, D; Kintscher, U; Scholze, J; Unger, T | 1 |
| Lu, XN; Sun, NL; Zhang, Q | 1 |
| Gutkowski, W; Janion, M; Sielski, J; Stepień, A | 1 |
| Baskurt, M; Kaya, A; Kucukoglu, S; Okcun, B; Ortak, K; Yigit, Z; Yildiz, A | 1 |
| Bognar, E; Bognar, Z; Gallyas, F; Hanto, K; Kiss, GN; Kiss, T; Kovacs, K; Rappai, G; Sumegi, B; Szabo, A; Tapodi, A | 1 |
| Roberts, WT; Timmis, AD; Timmis, JB; Wright, AR | 1 |
| Björkander, I; Ericson, M; Forslund, L; Hjemdahl, P; Kahan, T; Rehnqvist, N | 1 |
| Balamurgan, N; Senthilkumaran, S; Sweni, S; Thirumalaikolundusubramanian, P | 1 |
| Dimitrov, N; Georgiev, G; Kamenska, E; Kostova, B; Rachev, D | 1 |
| Jouyban, A; Soltani, S | 1 |
| Furutani, K; Inanobe, A; Kurachi, Y; Ohno, Y; Yamakawa, Y | 1 |
| Kryński, T; Kułakowski, P; Sikorska, A; Stec, S; Szymot, J; Zaborska, B | 1 |
| Pytkowski, M | 1 |
| Billing, E; Björkander, I; Eriksson, SV; Forslund, L; Held, C; Hjemdahl, P; Kahan, T; Näsman, P; Rehnqvist, N | 1 |
| Amidon, GL; Incecayir, T; Tsume, Y | 1 |
| Perlík, F | 1 |
| Abdelnoor, M; Arnesen, H; Enger, S; Gjesdal, K; Pripp, AH; Tveit, A; Ulimoen, SR | 1 |
| Abdelnoor, M; Arnesen, H; Enger, S; Gjesdal, K; Norseth, J; Pripp, AH; Tveit, A; Ulimoen, SR | 1 |
| Budakov, Z; Mikov, I; Mikov, M; Milijasević, B; Rasković, A; Vasović, V; Vukmirović, S | 1 |
| Corino, VD; Enger, S; Mainardi, LT; Platonov, PG; Tveit, A; Ulimoen, SR | 1 |
| Bermejo, M; Colon-Useche, S; González-Álvarez, I; González-Álvarez, M; Mangas-Sanjuan, V; Oltra-Noguera, D | 1 |
| Arnesen, H; Enger, S; Horjen, AW; Norseth, J; Seljeflot, I; Tveit, A; Ulimoen, SR | 1 |
| Brubaker, S; Koyfman, A; Long, B | 1 |
| Degim, T; Ilbasmis-Tamer, S; Incecayir, T; Tirnaksiz, F | 1 |
| Bedak, O; Begic, E; Bradaric, H; Custovic, F; Durak-Nalbantic, A; Hodzic, E; Mujakovic, A; Prnjavorac, B; Zvizdic, F | 1 |
| Andrews, LM; Koch, BCP; van der Nagel, BCH; van Domburg, B | 1 |
| Duan, X; Gui, Y; Jia, J; Li, S; Liu, CC; Liu, G; Lu, Y; Zhang, M | 1 |
| Bannister, BE; Parry, DR; Pouliot, JD | 1 |
| Ashley, EA; Bernstein, D; Huang, Y; Kawana, M; Kirillova, A; Lane, KV; Parikh, VN; Perez, MV; Pruitt, BL; Seo, K; Wang, Q; Wheeler, MT; Wu, JC; Yadav, S; Yamamoto, Y | 1 |
6 review(s) available for verapamil and metoprolol
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
New antiarrhythmic drugs.
Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half-Life; Humans; Hypertension; Lidocaine; Metoprolol; Nadolol; Nifedipine; Propanolamines; Propranolol; Tocainide; Verapamil | 1983 |
Refractory cardiogenic shock and complete heart block after verapamil SR and metoprolol treatment. A case report.
Topics: Aged; Delayed-Action Preparations; Drug Therapy, Combination; Emergencies; Female; Heart Block; Humans; Hypertension; Metoprolol; Shock, Cardiogenic; Verapamil | 1995 |
Pharmacological rate control of atrial fibrillation.
Topics: Amiodarone; Atenolol; Atrial Fibrillation; Cardiotonic Agents; Digoxin; Diltiazem; Heart Rate; Humans; Metoprolol; Randomized Controlled Trials as Topic; Verapamil | 2004 |
[Effect of liver cirrhosis on pharmacokinetics and pharmacodynamics of drugs].
Topics: Analgesics; Anesthetics, Local; Anti-Arrhythmia Agents; Antihypertensive Agents; Hepatic Insufficiency; Humans; Lidocaine; Liver; Liver Cirrhosis; Metoprolol; Propranolol; Risk; Verapamil | 2013 |
Alternative Treatment Options for Atrioventricular-Nodal-Reentry Tachycardia: An Emergency Medicine Review.
Topics: Adenosine; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Calcium Channel Blockers; Diltiazem; Electric Countershock; Electrocardiography; Emergency Medicine; Emergency Service, Hospital; Female; Humans; Male; Metoprolol; Propanolamines; Propranolol; Review Literature as Topic; Tachycardia, Atrioventricular Nodal Reentry; Vagus Nerve Stimulation; Verapamil | 2018 |
44 trial(s) available for verapamil and metoprolol
| Article | Year |
|---|---|
Effectiveness of antihypertensive medications in office and ambulatory settings: a placebo-controlled comparison of atenolol, metoprolol, chlorthalidone, verapamil, and an atenolol-chlorthalidone combination.
Topics: Adult; Ambulatory Care; Antihypertensive Agents; Atenolol; Blood Pressure; Blood Pressure Determination; Chlorthalidone; Double-Blind Method; Drug Combinations; Humans; Hypertension; Metoprolol; Middle Aged; Monitoring, Physiologic; Office Visits; Verapamil | 1992 |
Interaction between oral verapamil and beta-blockers during submaximal exercise: relevance of ancillary properties.
Topics: Administration, Oral; Adult; Blood Pressure; Double-Blind Method; Drug Interactions; Exercise; Heart; Heart Rate; Humans; Male; Metoprolol; Pindolol; Propranolol; Random Allocation; Verapamil | 1991 |
Treating hypertensive diabetics: a comparison of verapamil and metoprolol in black and white patients.
Topics: Albuminuria; Black People; Blood Glucose; Blood Pressure; Cholesterol; Diabetes Complications; Diabetes Mellitus; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Verapamil; White People | 1987 |
Digoxin or verapamil or metoprolol for heart rate control in patients with mitral stenosis--a randomised cross-over study.
Topics: Adult; Arrhythmia, Sinus; Atrial Fibrillation; Digoxin; Heart Rate; Humans; Metoprolol; Mitral Valve Stenosis; Random Allocation; Verapamil | 1989 |
A randomized, double-blind, placebo-controlled study of verapamil and metoprolol in treatment of multifocal atrial tachycardia.
Topics: Aged; Aged, 80 and over; Clinical Trials as Topic; Double-Blind Method; Female; Heart Atria; Heart Rate; Humans; Male; Metoprolol; Random Allocation; Tachycardia; Verapamil | 1988 |
Treating hypertension in black compared with white non-insulin dependent diabetics: a double blind trial of verapamil and metoprolol.
Topics: Aged; Albuminuria; Black or African American; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Metoprolol; Middle Aged; Patient Compliance; Renin; Verapamil | 1988 |
Influence of nitrendipine and verapamil on plasma levels, urinary excretion, and beta-blocking effect of metoprolol.
Topics: Adult; Female; Heart Rate; Humans; Male; Metoprolol; Nitrendipine; Verapamil | 1988 |
Pharmacokinetic interaction between oral metoprolol and verapamil for angina pectoris.
Topics: Administration, Oral; Adult; Angina Pectoris; Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Hemodynamics; Humans; Metoprolol; Random Allocation; Verapamil | 1986 |
The effects on left ventricular performance of verapamil and metoprolol singly and together in exercise-induced angina pectoris.
Topics: Adult; Angina Pectoris; Clinical Trials as Topic; Drug Interactions; Drug Therapy, Combination; Heart Ventricles; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Physical Exertion; Verapamil | 1985 |
Acute haemodynamic effects of felodipine and verapamil in man, singly and with metoprolol.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Felodipine; Heart Rate; Hemodynamics; Humans; Male; Metoprolol; Nifedipine; Regional Blood Flow; Stroke Volume; Vascular Resistance; Verapamil | 1985 |
Orthostatic response before and after nitroglycerin in metoprolol- and verapamil-treated angina pectoris.
Topics: Aged; Angina Pectoris; Blood Pressure; Heart Rate; Humans; Hypotension, Orthostatic; Metoprolol; Middle Aged; Nitroglycerin; Verapamil | 1983 |
[Modification of hemodynamics in tachycardiac atrial fibrillation by metoprolol and verapamil].
Topics: Atrial Fibrillation; Cardiac Output; Cardiomyopathy, Dilated; Heart Rate; Hemodynamics; Humans; Metoprolol; Middle Aged; Mitral Valve Insufficiency; Mitral Valve Stenosis; Pulmonary Wedge Pressure; Tachycardia; Vascular Resistance; Verapamil | 1983 |
[Comparative study of the combination of chlorthalidone with verapamil and metoprolol in arterial hypertension: evaluation by cycloergometrics].
Topics: Adult; Chlorthalidone; Clinical Trials as Topic; Drug Therapy, Combination; Exercise Test; Hemodynamics; Humans; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Verapamil | 1981 |
[Verapamil-hydrochlorothiazide vs. metoprolol-hydrochlorothiazide. Trial in hypertensive patients].
Topics: Adult; Clinical Trials as Topic; Drug Therapy, Combination; Humans; Hydrochlorothiazide; Hypertension; Male; Metoprolol; Middle Aged; Propanolamines; Verapamil | 1981 |
[Calcium antagonists and primary prevention of coronary disease].
Topics: Adult; Aged; Angina Pectoris; Coronary Disease; Double-Blind Method; Female; Humans; Male; Metoprolol; Middle Aged; Prospective Studies; Risk Factors; Time Factors; Verapamil | 1995 |
Platelet aggregability in vivo is attenuated by verapamil but not by metoprolol in patients with stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Catecholamines; Double-Blind Method; Humans; Male; Metoprolol; Middle Aged; Physical Exertion; Platelet Aggregation; Stress, Psychological; Verapamil | 1995 |
Treatment of silent ischemia in unstable angina: a randomized comparison of sustained-release verapamil versus metoprolol.
Topics: Adrenergic beta-Antagonists; Aged; Angina, Unstable; Calcium Channel Blockers; Delayed-Action Preparations; Electrocardiography, Ambulatory; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Ischemia; Vasodilator Agents; Verapamil | 1995 |
Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS)
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Calcium Channel Blockers; Double-Blind Method; Female; Humans; Male; Metoprolol; Middle Aged; Prognosis; Quality of Life; Survival Rate; Sweden; Treatment Outcome; Verapamil | 1996 |
Comparative study of the efficacy of metoprolol and verapamil in patients with syncope and positive head-up tilt test response.
Topics: Adolescent; Adult; Aged; Blood Pressure; Calcium Channel Blockers; Cross-Over Studies; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Recurrence; Reproducibility of Results; Sympatholytics; Syncope; Tilt-Table Test; Vasomotor System; Verapamil | 1996 |
Fibrinolytic variables and cardiovascular prognosis in patients with stable angina pectoris treated with verapamil or metoprolol. Results from the Angina Prognosis study in Stockholm.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Cardiovascular System; Female; Fibrinolysis; Follow-Up Studies; Humans; Male; Metoprolol; Middle Aged; Prognosis; Treatment Outcome; Verapamil | 1997 |
Psychosocial variables in female vs male patients with stable angina pectoris and matched healthy controls.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Calcium Channel Blockers; Chi-Square Distribution; Female; Humans; Life Change Events; Life Style; Male; Metoprolol; Middle Aged; Pain Measurement; Prospective Studies; Psychology; Reference Values; Risk Factors; Sex Factors; Sleep Wake Disorders; Stress, Psychological; Verapamil | 1997 |
Cardiovascular prognosis in relation to apolipoproteins and other lipid parameters in patients with stable angina pectoris treated with verapamil or metoprolol: results from the Angina Prognosis Study in Stockholm (APSIS).
Topics: Aged; Angina Pectoris; Apolipoproteins; Cardiovascular System; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Follow-Up Studies; Humans; Lipids; Male; Metoprolol; Middle Aged; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Assessment; Sweden; Time Factors; Treatment Outcome; Verapamil | 1997 |
Blood pressure and aortic elastic properties--verapamil SR/trandolapril compared to a metoprolol/hydrochlorothiazide combination therapy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Aorta; Blood Pressure; Bradycardia; Calcium Channel Blockers; Cough; Diuretics; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Metoprolol; Middle Aged; Sodium Chloride Symporter Inhibitors; Verapamil | 1998 |
Comparison of intravenous metoprolol, verapamil and diltiazem on the attenuation of haemodynamic changes associated with tracheal extubation.
Topics: Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Blood Pressure; Bradycardia; Diastole; Diltiazem; Heart Rate; Humans; Hypotension; Intervertebral Disc; Intubation, Intratracheal; Lumbar Vertebrae; Metoprolol; Middle Aged; Systole; Vasodilator Agents; Verapamil | 1999 |
Prognostic implications of ambulatory myocardial ischemia and arrhythmias and relations to ischemia on exercise in chronic stable angina pectoris (the Angina Prognosis Study in Stockholm [APSIS]).
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Electrocardiography, Ambulatory; Exercise Test; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Ischemia; Prognosis; Randomized Controlled Trials as Topic; Survival Analysis; Verapamil | 1999 |
Inflammatory and hemostatic markers in relation to cardiovascular prognosis in patients with stable angina pectoris. Results from the APSIS study. The Angina Prognosis Study in Stockholm.
Topics: Adrenergic beta-Agonists; Aged; Angina Pectoris; beta-Thromboglobulin; Calcium Channel Blockers; Cardiovascular Diseases; Double-Blind Method; Female; Fibrinogen; Hemostasis; Humans; Inflammation; Leukocyte Count; Male; Metoprolol; Middle Aged; Multivariate Analysis; Orosomucoid; Prognosis; Verapamil | 2000 |
Prognostic implications of results from exercise testing in patients with chronic stable angina pectoris treated with metoprolol or verapamil. A report from the Angina Prognosis Study In Stockholm (APSIS).
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Exercise Test; Female; Humans; Male; Metoprolol; Middle Aged; Multicenter Studies as Topic; Prognosis; Randomized Controlled Trials as Topic; Regression Analysis; Verapamil | 2000 |
Effect of metoprolol and verapamil administered separately and concurrently after single doses on liver blood flow and drug disposition.
Topics: Adult; Antihypertensive Agents; Area Under Curve; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Cross-Over Studies; Double-Blind Method; Drug Interactions; Heart Rate; Hepatic Artery; Hepatic Veins; Humans; Liver; Liver Circulation; Male; Metoprolol; Portal Vein; Regional Blood Flow; Stroke Volume; Time Factors; Vascular Resistance; Verapamil | 2000 |
Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris.
Topics: Aged; Angina Pectoris; Arteriosclerosis; Carotid Arteries; Carotid Artery Diseases; Coronary Artery Disease; Double-Blind Method; Female; Femoral Artery; Follow-Up Studies; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors; Sweden; Tunica Intima; Tunica Media; Ultrasonography; Verapamil | 2001 |
Prognostic implications of autonomic function assessed by analyses of catecholamines and heart rate variability in stable angina pectoris.
Topics: Adult; Aged; Angina Pectoris; Anti-Arrhythmia Agents; Autonomic Nervous System Diseases; Biomarkers; Catecholamines; Death, Sudden, Cardiac; Double-Blind Method; Electrocardiography, Ambulatory; Exercise; Exercise Test; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Sympatholytics; Verapamil | 2002 |
Effects of verapamil and metoprolol on recovery from atrial electrical remodeling after cardioversion of long-lasting atrial fibrillation.
Topics: Aged; Analysis of Variance; Atrial Fibrillation; Atrial Function; Calcium Channel Blockers; Echocardiography, Doppler; Electric Countershock; Electrophysiology; Female; Follow-Up Studies; Humans; Male; Metoprolol; Middle Aged; Probability; Prospective Studies; Risk Assessment; Severity of Illness Index; Treatment Outcome; Ventricular Remodeling; Verapamil | 2003 |
Favourable long term prognosis in stable angina pectoris: an extended follow up of the angina prognosis study in Stockholm (APSIS).
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Death, Sudden, Cardiac; Diabetic Angiopathies; Epidemiologic Factors; Female; Humans; Hypertension; Male; Metoprolol; Middle Aged; Myocardial Infarction; Prognosis; Sex Factors; Sweden; Verapamil | 2006 |
Prognostic implications of renal dysfunction in patients with stable angina pectoris.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Diseases; Creatinine; Double-Blind Method; Female; Humans; Kidney; Kidney Diseases; Male; Metabolic Clearance Rate; Metoprolol; Middle Aged; Myocardial Infarction; Prognosis; Prospective Studies; Treatment Outcome; Verapamil | 2006 |
Optimal treatment of obesity-related hypertension: the Hypertension-Obesity-Sibutramine (HOS) study.
Topics: Adult; Aged; Antihypertensive Agents; Appetite Depressants; Blood Pressure; Body Weight; Cyclobutanes; Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Felodipine; Female; Humans; Hydrochlorothiazide; Hypertension; Indoles; Male; Metoprolol; Middle Aged; Obesity; Prospective Studies; Ramipril; Treatment Outcome; Verapamil | 2007 |
[Effects of Verapamil and Metoprolol on heart rate variability in patients with coronary heart disease].
Topics: Anti-Arrhythmia Agents; Coronary Disease; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Verapamil | 2007 |
Differential index: a simple time domain heart rate variability analysis with prognostic implications in stable angina pectoris.
Topics: Aged; Angina Pectoris; Cause of Death; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Kaplan-Meier Estimate; Male; Metoprolol; Middle Aged; Predictive Value of Tests; Probability; Prognosis; Prospective Studies; Risk Assessment; ROC Curve; Sensitivity and Specificity; Severity of Illness Index; Survival Rate; Time Factors; Treatment Outcome; Verapamil | 2008 |
Comparison of rate and rhythm control in hypertension patients with atrial fibrillation.
Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Atrial Fibrillation; Calcium Channel Blockers; Cardiotonic Agents; Digoxin; Electric Countershock; Female; Follow-Up Studies; Humans; Hypertension; Losartan; Male; Metoprolol; Middle Aged; Survival Analysis; Treatment Outcome; Verapamil | 2008 |
Long-term stability of heart rate variability in chronic stable angina pectoris, and the impact of an acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Aged; Angina Pectoris; Calcium Channel Blockers; Chronic Disease; Coronary Artery Disease; Double-Blind Method; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Models, Cardiovascular; Myocardial Infarction; Predictive Value of Tests; Reproducibility of Results; Risk Assessment; Sweden; Time Factors; Verapamil | 2009 |
Benign symptomatic premature ventricular complexes: short- and long-term efficacy of antiarrhythmic drugs and radiofrequency ablation.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anti-Arrhythmia Agents; Catheter Ablation; Cross-Over Studies; Female; Follow-Up Studies; Humans; Male; Metoprolol; Middle Aged; Propafenone; Prospective Studies; Severity of Illness Index; Time Factors; Treatment Outcome; Ventricular Premature Complexes; Verapamil; Young Adult | 2012 |
Risk prediction in stable angina pectoris.
Topics: Aged; Angina, Stable; Anti-Arrhythmia Agents; Blood Glucose; Creatinine; Double-Blind Method; Female; Glucose Tolerance Test; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Risk Factors; Verapamil | 2013 |
Calcium channel blockers improve exercise capacity and reduce N-terminal Pro-B-type natriuretic peptide levels compared with beta-blockers in patients with permanent atrial fibrillation.
Topics: Adrenergic beta-Antagonists; Aged; Atrial Fibrillation; Calcium Channel Blockers; Carbazoles; Carvedilol; Cross-Over Studies; Delayed-Action Preparations; Diltiazem; Exercise Tolerance; Female; Humans; Male; Metoprolol; Natriuretic Peptide, Brain; Oxygen Consumption; Peptide Fragments; Propanolamines; Prospective Studies; Verapamil | 2014 |
Improved rate control reduces cardiac troponin T levels in permanent atrial fibrillation.
Topics: Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Biomarkers; Carbazoles; Carvedilol; Cross-Over Studies; Diltiazem; Down-Regulation; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Norway; Propanolamines; Prospective Studies; Time Factors; Treatment Outcome; Troponin T; Verapamil | 2014 |
Rate-control drugs affect variability and irregularity measures of RR intervals in patients with permanent atrial fibrillation.
Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Carbazoles; Carvedilol; Cross-Over Studies; Diltiazem; Electrocardiography, Ambulatory; Female; Heart Conduction System; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Norway; Propanolamines; Time Factors; Treatment Outcome; Verapamil | 2015 |
Troponin I levels in permanent atrial fibrillation-impact of rate control and exercise testing.
Topics: Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atrial Fibrillation; Biomarkers; Calcium Channel Blockers; Carbazoles; Carvedilol; Cross-Over Studies; Diltiazem; Down-Regulation; Exercise Test; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Norway; Predictive Value of Tests; Propanolamines; Treatment Outcome; Troponin I; Troponin T; Verapamil | 2016 |
130 other study(ies) available for verapamil and metoprolol
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Accumulation of drugs by guinea pig isolated atria. Quantitative correlations.
Topics: Animals; Chemistry, Pharmaceutical; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Myocardium; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Solubility; Time Factors | 1980 |
Physicochemical high throughput screening: parallel artificial membrane permeation assay in the description of passive absorption processes.
Topics: Absorption; Adsorption; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Intestinal Absorption; Membranes, Artificial; Permeability; Pharmacokinetics; Spectrophotometry, Ultraviolet | 1998 |
SPR biosensor studies of the direct interaction between 27 drugs and a liposome surface: correlation with fraction absorbed in humans.
Topics: Humans; Intestinal Absorption; Liposomes; Pharmaceutical Preparations; Pharmacokinetics; Predictive Value of Tests; Surface Plasmon Resonance | 2000 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Inactivation, Metabolic; Liver; Microsomes, Liver; Models, Biological; Permeability; Pharmacokinetics; Rats; Species Specificity | 2002 |
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis).
Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine | 2002 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
In silico prediction of membrane permeability from calculated molecular parameters.
Topics: Animals; Cell Line; Cell Membrane Permeability; Diffusion; Dogs; Humans; Intestinal Absorption; Models, Biological; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2005 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
QSAR study on permeability of hydrophobic compounds with artificial membranes.
Topics: Biological Transport; Caco-2 Cells; Drug Evaluation, Preclinical; Humans; Hydrophobic and Hydrophilic Interactions; Membranes, Artificial; Permeability; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship | 2007 |
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs.
Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization | 2008 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry | 2009 |
Lipophilicity of basic drugs measured by hydrophilic interaction chromatography.
Topics: Chemistry, Pharmaceutical; Chromatography; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Pharmaceutical Preparations; Solubility; Technology, Pharmaceutical | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Importance of physicochemical properties for the design of new pesticides.
Topics: Anabasine; Animals; Biological Availability; Cell Membrane Permeability; Chemical Phenomena; Drug Design; Humans; Imidazoles; Insecticides; Neonicotinoids; Nitro Compounds; Pesticides; Quantitative Structure-Activity Relationship; Receptors, Nicotinic | 2011 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Imidazo[1,2-a]pyridin-3-amines as potential HIV-1 non-nucleoside reverse transcriptase inhibitors.
Topics: Cell Line; Cell Survival; HIV Reverse Transcriptase; HIV-1; Humans; Imidazoles; Models, Molecular; Molecular Structure; Pyridines; Reverse Transcriptase Inhibitors; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Predicting phenolic acid absorption in Caco-2 cells: a theoretical permeability model and mechanistic study.
Topics: Artificial Intelligence; Caco-2 Cells; Cell Membrane Permeability; Cinnamates; Enterocytes; Humans; Hydrophobic and Hydrophilic Interactions; Intestinal Absorption; Kinetics; Models, Biological; Molecular Conformation; Osmolar Concentration; Phenols | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors.
Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity | 2013 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors.
Topics: Animals; Blood-Brain Barrier; Brain; Crystallography, X-Ray; Gastrointestinal Tract; Humans; Indazoles; Kinetics; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Permeability; Protein Binding; Protein Conformation; Rats; Solubility; Species Specificity; Structure-Activity Relationship; Water | 2017 |
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
Topics: Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Drug Discovery; Fluorescence Resonance Energy Transfer; Half-Life; Humans; Mass Spectrometry; Mice; Proteins; Proton Magnetic Resonance Spectroscopy; Pyridones; Structure-Activity Relationship; Sulfonamides | 2017 |
N
Topics: Animals; Catalysis; Catalytic Domain; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Kinetics; Lysine; Mice; Microsomes, Liver; Models, Molecular; Molecular Structure; Protein Conformation; Protein Glutamine gamma Glutamyltransferase 2; Pyridazines; Structure-Activity Relationship; Tissue Distribution; Transglutaminases | 2018 |
Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB.
Topics: Animals; Antitubercular Agents; Chlorocebus aethiops; Cytochromes c; Mice; Morpholines; Mycobacterium tuberculosis; Oxidoreductases; Structure-Activity Relationship; Thiophenes; Vero Cells | 2018 |
Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.
Topics: | 2020 |
Substituted benzothiophene and benzofuran derivatives as a novel class of bone morphogenetic Protein-2 upregulators: Synthesis, anti-osteoporosis efficacies in ovariectomized rats and a zebrafish model, and ADME properties.
Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish | 2020 |
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.
Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones | 2021 |
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain; Caco-2 Cells; Dose-Response Relationship, Drug; Drug Discovery; HEK293 Cells; Humans; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Molecular Structure; Neuralgia; Protein Kinases; Protein Serine-Threonine Kinases; Structure-Activity Relationship | 2021 |
Paroxysmal nonreentrant tachycardias due to simultaneous conduction in dual atrioventricular nodal pathways.
Topics: Adult; Ajmaline; Atrial Fibrillation; Atrioventricular Node; Atropine; Bundle of His; Cardiac Pacing, Artificial; Electrocardiography; Heart Block; Heart Conduction System; Humans; Lidocaine; Male; Metoprolol; Models, Biological; Tachycardia, Paroxysmal; Verapamil | 1979 |
Series on pharmacology in practice. 2. Antiarrhythmic drug therapy.
Topics: Anti-Arrhythmia Agents; Bretylium Compounds; Disopyramide; Humans; Lidocaine; Metoprolol; Procainamide; Propranolol; Quinidine; Verapamil | 1979 |
[Therapy of coronary disease].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Aspirin; Calcium Channel Blockers; Clinical Trials as Topic; Coronary Disease; Diltiazem; Dipyridamole; Drug Therapy, Combination; Humans; Isosorbide Dinitrate; Metoprolol; Nitrates; Smoking; Verapamil | 1992 |
Halothane increases epinephrine threshold for the development of slow responses in isolated canine trabeculae.
Topics: Animals; Calcium Channels; Connective Tissue; Dogs; Dose-Response Relationship, Drug; Drug Interactions; Electrocardiography; Epinephrine; Female; Halothane; Heart; Male; Metoprolol; Prazosin; Verapamil | 1991 |
Hemodynamic effects of inosine in combination with positive and negative inotropic drugs: studies on rats in vivo.
Topics: Adenosine Deaminase; Animals; Anti-Arrhythmia Agents; Cardiac Output; Cardiotonic Agents; Chromatography, High Pressure Liquid; Cyclic AMP; Female; Heart Rate; Hemodynamics; In Vitro Techniques; Infusions, Intravenous; Inosine; Metoprolol; Myocardial Contraction; Norepinephrine; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Transport of beta-blockers and calcium antagonists by diffusion in cat myocardium.
Topics: Adrenergic beta-Antagonists; Animals; Atenolol; Biological Transport; Calcium Channel Blockers; Cats; Diffusion; In Vitro Techniques; Metoprolol; Myocardium; Propranolol; Sucrose; Verapamil | 1991 |
Interactions between verapamil and metoprolol in the developing chick embryo heart.
Topics: Animals; Calcium; Chick Embryo; Drug Synergism; Heart; Metoprolol; Myocardium; Teratogens; Verapamil | 1991 |
Assessment of the beta 2 adrenoceptor and Ca2+ channel-blocking activity of drugs with the rat portal vein.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Dobutamine; Isoproterenol; Male; Metoprolol; Muscle Contraction; Portal Vein; Propanolamines; Propranolol; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Verapamil | 1990 |
Free radical generation, lipid peroxidation and essential fatty acids in uncontrolled essential hypertension.
Topics: Angiotensin II; Antihypertensive Agents; Endothelium, Vascular; Epoprostenol; Fatty Acids, Essential; Free Radicals; Humans; Hydrogen Peroxide; Hypertension; Lipid Peroxidation; Metoprolol; Neutrophils; Nitric Oxide; Oxidation-Reduction; Superoxides; Tetradecanoylphorbol Acetate; Verapamil | 1990 |
Functional and metabolic effects of ribose in combination with prazosin, verapamil and metoprolol in rats in vivo.
Topics: Adenine Nucleotides; Animals; Drug Interactions; Energy Metabolism; Heart; Hemodynamics; Metoprolol; Muscles; Myocardium; Phosphoribosyl Pyrophosphate; Prazosin; Rats; Rats, Inbred Strains; Ribose; Verapamil; Viscera | 1989 |
[Drugs in secondary prevention of ischemic heart disease: achievements, problems and prospects].
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Coronary Disease; Female; Humans; Isosorbide Dinitrate; Male; Metoprolol; Nadolol; Nifedipine; Nitrates; Nitroglycerin; Propranolol; Verapamil | 1989 |
Tolerability of combined treatment with verapamil and beta-blockers in angina resistant to monotherapy.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angina Pectoris; Atenolol; Drug Therapy, Combination; Drug Tolerance; Female; Heart; Humans; Male; Metoprolol; Middle Aged; Pindolol; Propranolol; Verapamil | 1985 |
The use of beta-adrenergic blocking agents, i.v. nitrates and calcium channel blocking agents following acute myocardial infarction.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Humans; Infusions, Intravenous; Metoprolol; Myocardial Infarction; Nifedipine; Nitrates; Nitroglycerin; Nitroprusside; Verapamil | 1988 |
Combination of ribose with calcium antagonist and beta-blocker treatment in closed-chest rats.
Topics: Adenine Nucleotides; Animals; Cardiac Output; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Female; Heart Diseases; Hemodynamics; Metoprolol; Myocardium; Rats; Rats, Inbred Strains; Ribose; Verapamil | 1987 |
Comparison of different pharmacological interventions on enzymatic parameters during acute myocardial infarction.
Topics: Adult; Aged; Clinical Enzyme Tests; Creatine Kinase; Dipyridamole; Female; Heart; Heparin; Humans; Isoenzymes; Isosorbide Dinitrate; Male; Metoprolol; Middle Aged; Myocardial Infarction; Myocardium; Necrosis; Nifedipine; Nitroglycerin; Streptokinase; Verapamil | 1987 |
Comparative investigations on the antiarrhythmic and electrophysiologic effects of class I-IV antiarrhythmic agents following acute coronary artery occlusion.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Disease; Dogs; Female; Heart Conduction System; Lidocaine; Male; Metoprolol; Myocardial Infarction; Sotalol; Ventricular Fibrillation; Verapamil | 1987 |
Cardiac arrest in an adolescent with atrial fibrillation and hypertrophic cardiomyopathy.
Topics: Adolescent; Atrial Fibrillation; Cardiac Catheterization; Cardiac Pacing, Artificial; Cardiomyopathy, Hypertrophic; Electrophysiology; Follow-Up Studies; Heart Arrest; Humans; Male; Metoprolol; Ventricular Fibrillation; Verapamil | 1986 |
Postcountershock myocardial damage after pretreatment with adrenergic and calcium channel antagonists in halothane-anesthetized dogs.
Topics: Anesthesia, Inhalation; Animals; Calcium Channel Blockers; Dogs; Electric Countershock; Female; Halothane; Heart; Male; Metoprolol; Myocardium; Necrosis; Prazosin; Radionuclide Imaging; Sympatholytics; Technetium; Technetium Tc 99m Pyrophosphate; Tin Polyphosphates; Verapamil | 1985 |
Clearance-based oral drug interaction between verapamil and metoprolol and comparison with atenolol.
Topics: Administration, Oral; Angina Pectoris; Atenolol; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypertension; Metabolic Clearance Rate; Metoprolol; Middle Aged; Verapamil | 1985 |
A study on the effects of some drugs on DOCA induced hypertension in the rat.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Diuretics; Hypertension; Indoramin; Male; Metoprolol; Prazosin; Pulmonary Artery; Rats; Verapamil | 1980 |
[Tocolysis, a therapeutic measure requiring caution].
Topics: Adrenergic beta-Agonists; Energy Metabolism; Female; Heart; Humans; Magnesium; Metoprolol; Obstetric Labor, Premature; Potassium; Pregnancy; Verapamil | 1980 |
Comparative investigation of the effects of metoprolol, propranolol, practolol, and verapamil in the acute phase of experimental myocardial infarction.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Blood Pressure; Calcium Channel Blockers; Central Venous Pressure; Creatine Kinase; Hydrogen-Ion Concentration; Metoprolol; Myocardial Infarction; Practolol; Propanolamines; Propranolol; Rats; Verapamil | 1982 |
Adverse interaction between beta-adrenergic blocking drugs and verapamil--report of three cases.
Topics: Adrenergic beta-Antagonists; Aged; Bradycardia; Coronary Disease; Drug Interactions; Drug Therapy, Combination; Female; Heart Failure; Humans; Hypotension; Male; Metoprolol; Middle Aged; Pindolol; Verapamil | 1982 |
Pharmacokinetics and pharmacodynamics of verapamil in combination with atenolol, metoprolol and propranolol.
Topics: Adrenergic beta-Antagonists; Adult; Atenolol; Blood Pressure; Drug Interactions; Female; Half-Life; Heart Diseases; Heart Rate; Humans; Kinetics; Male; Metoprolol; Propranolol; Verapamil | 1984 |
Treatment of unstable angina with emphasis on calcium antagonists.
Topics: Angina Pectoris; Angina, Unstable; Anticoagulants; Coronary Circulation; Coronary Disease; Electrocardiography; Humans; Isosorbide Dinitrate; Metoprolol; Nifedipine; Nitroglycerin; Oxygen Consumption; Propranolol; Verapamil | 1984 |
Mechanism of protection from atherosclerosis by verapamil in the cholesterol-fed rabbit.
Topics: Animals; Aorta; Arteriosclerosis; Blood Pressure; Cholesterol; Cholesterol, Dietary; Heart Rate; Hydralazine; Lipids; Metoprolol; Rabbits; Triglycerides; Verapamil | 1984 |
Probable adverse interaction between oral metoprolol and verapamil.
Topics: Angina Pectoris; Drug Interactions; Drug Therapy, Combination; Heart Block; Humans; Male; Metoprolol; Middle Aged; Verapamil | 1984 |
Effects of metoprolol on digitalis-resistant atrial tachyarrhythmias in chronic obstructive pulmonary disease.
Topics: Aged; Digitalis; Drug Therapy, Combination; Female; Heart Rate; Humans; Lung Diseases, Obstructive; Male; Metoprolol; Middle Aged; Ouabain; Plants, Medicinal; Plants, Toxic; Tachycardia; Verapamil | 1984 |
Myocardial infarct size limitation. Principles, problems and possibilities.
Topics: Allopurinol; Animals; Coronary Circulation; Dogs; Flurbiprofen; Humans; Metoprolol; Myocardial Infarction; Nifedipine; Tetrazolium Salts; Verapamil | 1984 |
Prinzmetal's variant angina.
Topics: Aged; Angina Pectoris; Angina Pectoris, Variant; Diagnosis, Differential; Electrocardiography; Female; Humans; Male; Metoprolol; Middle Aged; Nifedipine; Nitroglycerin; Propranolol; Verapamil | 1981 |
Comparison of metoprolol and verapamil in the treatment of angina pectoris.
Topics: Adult; Angina Pectoris; Double-Blind Method; Female; Humans; Male; Metoprolol; Middle Aged; Nitroglycerin; Physical Exertion; Propanolamines; Verapamil | 1982 |
Hemodynamic consequences of combined beta-adrenergic and slow calcium channel blockade in man.
Topics: Adult; Aged; Angina Pectoris; Coronary Disease; Drug Therapy, Combination; Electrocardiography; Female; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Propanolamines; Propranolol; Verapamil | 1982 |
[Verapamil as a hypotensive agent. Clinical, laboratory, electro- and echocardiographic study].
Topics: Adult; Aged; Chlorthalidone; Echocardiography; Electrocardiography; Female; Humans; Hypertension; Liver; Male; Metoprolol; Middle Aged; Propanolamines; Verapamil | 1981 |
Amiodarone is a dose-dependent noncompetitive and competitive inhibitor of T3 binding to thyroid hormone receptor subtype beta 1, whereas disopyramide, lignocaine, propafenone, metoprolol, dl-sotalol, and verapamil have no inhibitory effect.
Topics: Amiodarone; Anti-Arrhythmia Agents; Binding, Competitive; Disopyramide; Dose-Response Relationship, Drug; Humans; Lidocaine; Metoprolol; Propafenone; Receptors, Thyroid Hormone; Sotalol; Triiodothyronine; Verapamil | 1995 |
Antifibrillary action of class I-IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs.
Topics: Adrenergic beta-Antagonists; Animals; Anti-Arrhythmia Agents; Atenolol; Benzopyrans; Chromans; Disease Models, Animal; Electric Stimulation; Electrocardiography; Encainide; Ethanolamines; Guinea Pigs; Heart; Heart Conduction System; Injections, Intravenous; Male; Metoprolol; Nebivolol; Phenethylamines; Piperidines; Sotalol; Sulfonamides; Ventricular Fibrillation; Verapamil | 1995 |
Regioselective and stereoselective oxidation of metoprolol and bufuralol catalyzed by microsomes containing cDNA-expressed human P4502D6.
Topics: Adrenergic beta-Antagonists; Biotransformation; Catalysis; Cells, Cultured; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dealkylation; DNA; Ethanolamines; Humans; In Vitro Techniques; Kinetics; Metoprolol; Microsomes, Liver; Mixed Function Oxygenases; Oxidation-Reduction; Spectrometry, Fluorescence; Stereoisomerism; Verapamil | 1995 |
Primary prevention in patients with coronary heart disease: the APSIS study.
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Coronary Disease; Female; Humans; Male; Metoprolol; Middle Aged; Prognosis; Vasodilator Agents; Verapamil | 1995 |
Stability of labetalol hydrochloride, metoprolol tartrate, verapamil hydrochloride, and spironolactone with hydrochlorothiazide in extemporaneously compounded oral liquids.
Topics: Antihypertensive Agents; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Diuretics; Dosage Forms; Drug Compounding; Drug Stability; Humans; Hydrochlorothiazide; Labetalol; Metoprolol; Sodium Chloride Symporter Inhibitors; Spironolactone; Suspensions; Verapamil | 1996 |
Glucagon for reaction to combined calcium channel blocker and beta-blocker use.
Topics: Adrenergic beta-Antagonists; Calcium Channel Blockers; Drug Interactions; Emergency Nursing; Glucagon; Humans; Male; Metoprolol; Middle Aged; Verapamil | 1996 |
[Pharmacotherapy of silent myocardial ischemia in patients on hemodialysis].
Topics: Adrenergic beta-Agonists; Adult; Aged; Calcium Channel Blockers; Female; Humans; Kidney Failure, Chronic; Male; Metoprolol; Middle Aged; Myocardial Ischemia; Nitroglycerin; Renal Dialysis; Vasodilator Agents; Verapamil | 1996 |
On-line column-switching high-performance liquid chromatography analysis of cardiovascular drugs in serum with automated sample clean-up and zone-cutting technique to perform chiral separation.
Topics: Cardiovascular Agents; Chromatography, High Pressure Liquid; Diltiazem; Lidocaine; Linear Models; Metoprolol; Online Systems; Oxprenolol; Pindolol; Sensitivity and Specificity; Stereoisomerism; Verapamil | 1997 |
Myocardial oxygen tension and capillary density in the isolated perfused rat heart during pharmacological intervention.
Topics: Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Biological Transport, Active; Calcium Channel Blockers; Capillaries; Dobutamine; Electron Spin Resonance Spectroscopy; Heart; In Vitro Techniques; Indoles; Male; Metoprolol; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organometallic Compounds; Oxygen; Oxygen Consumption; Perfusion; Rats; Rats, Wistar; Spin Labels; Vasoconstrictor Agents; Vasopressins; Ventricular Function, Left; Verapamil | 1997 |
[Stable angina pectoris: what is the role of calcium antagonists?].
Topics: Adrenergic beta-Antagonists; Angina Pectoris; Atenolol; Calcium Channel Blockers; Clinical Trials as Topic; Dihydropyridines; Diltiazem; Drug Therapy, Combination; Felodipine; Humans; Metoprolol; Multicenter Studies as Topic; Nifedipine; Randomized Controlled Trials as Topic; Verapamil | 1997 |
Pheochromocytoma crisis caused by contemporary ergotamine, caffeine, and nimesulide administration.
Topics: Adrenal Gland Neoplasms; Adult; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Caffeine; Drug Combinations; Ergotamine; Humans; Hypertension; Male; Metoprolol; Multiple Organ Failure; Pheochromocytoma; Sulfonamides; Verapamil | 1997 |
Effects of antihypertensive drugs on cholesterol metabolism of human mononuclear leukocytes and hepatoma cells.
Topics: Antihypertensive Agents; Carcinoma, Hepatocellular; Cholesterol; Diltiazem; Humans; Leukocytes, Mononuclear; Liver Neoplasms; Metoprolol; Nifedipine; Propranolol; Tumor Cells, Cultured; Verapamil | 1998 |
Beta-adrenergic signalling and threshold adrenaline concentration for induction of fibrillation in the perfused heart pretreated with antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Cyclic AMP; Enalapril; Epinephrine; GTP-Binding Proteins; In Vitro Techniques; Male; Metoprolol; Perfusion; Potassium; Rats; Rats, Wistar; Receptors, Adrenergic, beta; Signal Transduction; Timolol; Verapamil | 1999 |
Enantiomer separation by strong anion-exchange capillary electrochromatography with dynamically modified sulfated beta-cyclodextrin.
Topics: Anions; Atropine; beta-Cyclodextrins; Cyclodextrins; Electrophoresis, Capillary; Metoprolol; Molecular Structure; Praziquantel; Tryptophan; Verapamil | 2001 |
Ethnic, racial, and sex-specific factors are important in cardiovascular pharmacotherapeutics.
Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Black People; Cardiovascular Agents; Cardiovascular Diseases; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Metoprolol; Phenotype; Polymorphism, Genetic; Prevalence; Sex Factors; Verapamil; White People | 2002 |
Diagnostic value of simultaneous non-invasive continuous, ambulatory finger blood pressure and electrocardiogram monitoring in a patient with hypertrophic obstructive cardiomyopathy.
Topics: Anti-Arrhythmia Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Cardiomyopathy, Hypertrophic; Electrocardiography, Ambulatory; Exercise; Female; Fingers; Hemodynamics; Humans; Metoprolol; Middle Aged; Verapamil | 2002 |
An autopsy case of combined drug intoxication involving verapamil, metoprolol and digoxin.
Topics: Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Digoxin; Drug Interactions; Drug Overdose; Humans; Male; Metoprolol; Suicide; Verapamil | 2003 |
The heart of Daphnia magna: effects of four cardioactive drugs.
Topics: Animals; Cardiotonic Agents; Daphnia; Dose-Response Relationship, Drug; Heart; Heart Rate; Lethal Dose 50; Metaproterenol; Metoprolol; Ouabain; Sodium Dodecyl Sulfate; Verapamil | 2003 |
Cardiovascular effects of the toxin(s) of the Australian paralysis tick, Ixodes holocyclus, in the rat.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Antitoxins; Cimetidine; Dose-Response Relationship, Drug; Electrophysiology; Histological Techniques; Ixodes; Male; Metoprolol; Microelectrodes; Microscopy, Electron; Myocardial Contraction; Myocardium; Pinacidil; Pyrilamine; Rats; Rats, Wistar; Spider Venoms; Tetrodotoxin; Verapamil | 2004 |
Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry.
Topics: Atmospheric Pressure; Chromatography, Thin Layer; Metoprolol; Midazolam; Models, Molecular; Molecular Weight; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Verapamil | 2005 |
The impact of diabetes or elevated fasting blood glucose on cardiovascular prognosis in patients with stable angina pectoris.
Topics: Angina Pectoris; Anti-Arrhythmia Agents; Blood Glucose; Cardiovascular Diseases; Diabetic Angiopathies; Fasting; Female; Humans; Male; Metoprolol; Middle Aged; Prognosis; Prospective Studies; Risk Factors; Verapamil | 2005 |
Development of an on-line extraction turbulent flow chromatography tandem mass spectrometry method for cassette analysis of Caco-2 cell based bi-directional assay samples.
Topics: Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Dexamethasone; Etoposide; Furosemide; Humans; Metoprolol; Nadolol; Pharmaceutical Preparations; Propranolol; Quinidine; Rhodamine 123; Spectrometry, Mass, Electrospray Ionization; Sulfasalazine; Verapamil | 2006 |
The use of low-dose insulin in cardiogenic shock due to combined overdose of verapamil, enalapril and metoprolol.
Topics: Antihypertensive Agents; Drug Synergism; Enalapril; Female; Humans; Hypoglycemic Agents; Insulin; Metoprolol; Middle Aged; Shock, Cardiogenic; Vasodilator Agents; Verapamil | 2006 |
Verapamil decreases ventricular tachyarrhythmias in a patient with Timothy syndrome (LQT8).
Topics: Adrenergic beta-Antagonists; Adult; Calcium Channel Blockers; Combined Modality Therapy; Defibrillators, Implantable; Electrocardiography; Heart Arrest; Humans; Long QT Syndrome; Male; Metoprolol; Reoperation; Syncope; Ventricular Fibrillation; Verapamil | 2006 |
Attenuation of the negative inotropic effects of metoprolol at short cycle lengths in humans: comparison with sotalol and verapamil.
Topics: Aged; Anti-Arrhythmia Agents; Cardiac Catheterization; Cardiac Pacing, Artificial; Female; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Myocardial Contraction; Myocardial Ischemia; Pressure; Sotalol; Systole; Time Factors; Ventricular Function, Left; Verapamil | 2006 |
[Characteristics of action of various drugs blocking atrioventricular conduction (beta-blockers, verapamil, diltiazem) in constant fibrillation tachyarrhythmia. Is monotherapy optimal?].
Topics: Adrenergic beta-Antagonists; Adult; Aged; Atenolol; Atrioventricular Node; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Treatment Outcome; Ventricular Fibrillation; Verapamil | 2006 |
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry.
Topics: Amiodarone; Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carbazoles; Carvedilol; Chromatography, Liquid; Diltiazem; Humans; Metoprolol; Mexiletine; Molecular Structure; Propanolamines; Propranolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry; Verapamil | 2007 |
In-vitro mutagenic potential and effect on permeability of co-administered drugs across Caco-2 cell monolayers of Rubus idaeus and its fortified fractions.
Topics: Acetaminophen; Anthocyanins; Biological Transport; Caco-2 Cells; Cell Membrane Permeability; Cell Survival; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Fluorenes; Fruit; Humans; Hydrolyzable Tannins; Ketoprofen; Metoprolol; Mutagenicity Tests; Plant Extracts; Rosaceae; Salmonella typhimurium; Spectrometry, Mass, Electrospray Ionization; Verapamil | 2006 |
Left ventricular volume and function in cynomolgus monkeys using real-time three-dimensional echocardiography.
Topics: Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Echocardiography, Three-Dimensional; Heart Ventricles; Macaca fascicularis; Male; Metoprolol; Propranolol; Ventricular Function; Verapamil | 2007 |
Is the intra-aortic balloon pump a method of brain protection during cardiogenic shock after drug intoxication?
Topics: Adolescent; Adrenergic beta-Antagonists; Amlodipine; Anti-Inflammatory Agents, Non-Steroidal; Brain Diseases; Calcium Channel Blockers; Female; Humans; Ibuprofen; Intra-Aortic Balloon Pumping; Metoprolol; Shock, Cardiogenic; Suicide, Attempted; Verapamil | 2010 |
Prevalent role of Akt and ERK activation in cardioprotective effect of Ca(2+) channel- and beta-adrenergic receptor blockers.
Topics: Adrenergic beta-Antagonists; Animals; Benzimidazoles; Calcium Channel Blockers; Cardiotonic Agents; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Humans; Hydrogen-Ion Concentration; Lipid Peroxidation; Male; Metoprolol; Myocardial Infarction; Myocardium; Oxidation-Reduction; Phosphates; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury; Signal Transduction; Verapamil | 2009 |
Safety and efficacy of a rate control protocol for cardiac CT.
Topics: Anti-Arrhythmia Agents; Artifacts; Clinical Protocols; Coronary Angiography; Coronary Disease; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Male; Metoprolol; Tomography, X-Ray Computed; Treatment Outcome; Verapamil | 2009 |
Acute episode of reversible blindness after an overdose of beta blockers and calcium channel antagonist.
Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Blindness; Calcium Channel Blockers; Drug Overdose; Female; Humans; Metoprolol; Middle Aged; Verapamil | 2011 |
Morphology of new zwitterionic copolymer matrices for sustained drug release.
Topics: Delayed-Action Preparations; Methacrylates; Metoprolol; Microscopy, Electron, Scanning; Microspheres; Polyvinyls; Quaternary Ammonium Compounds; Verapamil | 2010 |
A validated micellar LC method for simultaneous determination of furosemide, metoprolol and verapamil in human plasma.
Topics: Blood Chemical Analysis; Chromatography, Liquid; Furosemide; Humans; Metoprolol; Micelles; Verapamil | 2012 |
Pharmacophore modeling for hERG channel facilitation.
Topics: Animals; Atenolol; Chlorpheniramine; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoxetine; Haloperidol; Humans; Hydrophobic and Hydrophilic Interactions; Imipramine; Metoprolol; Nortriptyline; Potassium Channel Blockers; Promethazine; Propranolol; Quantitative Structure-Activity Relationship; Sotalol; Terfenadine; Verapamil; Xenopus laevis | 2012 |
[Not so simple procedure in "simple" arrhythmias of ventricular].
Topics: Anti-Arrhythmia Agents; Catheter Ablation; Female; Humans; Male; Metoprolol; Propafenone; Ventricular Premature Complexes; Verapamil | 2012 |
Comparison of the permeability of metoprolol and labetalol in rat, mouse, and Caco-2 cells: use as a reference standard for BCS classification.
Topics: Animals; Biological Transport; Caco-2 Cells; Humans; Ileum; Jejunum; Labetalol; Metoprolol; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar; Verapamil | 2013 |
Effect of aqueous solution of stevioside on pharmacological properties of some cardioactive drugs.
Topics: Animals; Cardiovascular Agents; Diterpenes, Kaurane; Drug Interactions; Epinephrine; Female; Glucosides; Heart Rate; Male; Metoprolol; Rats; Rats, Wistar; Solutions; Sweetening Agents; Verapamil | 2014 |
Drug gastrointestinal absorption in rat: Strain and gender differences.
Topics: Animals; Female; Intestinal Absorption; Male; Metoprolol; Rats, Long-Evans; Rats, Sprague-Dawley; Rats, Wistar; Sex Characteristics; Species Specificity; Verapamil | 2015 |
Assessment of the potential drug-drug interaction between carvedilol and clopidogrel mediated through intestinal P-glycoprotein.
Topics: Adrenergic beta-Antagonists; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carbazoles; Carvedilol; Clopidogrel; Drug Interactions; Intestinal Absorption; Intestine, Small; Male; Metoprolol; Perfusion; Permeability; Platelet Aggregation Inhibitors; Propanolamines; Rats; Rats, Wistar; Ticlopidine; Verapamil | 2016 |
Beta-blocker Use in Moderate and Severe Chronic Obstructive Pulmonary Disease.
Topics: Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bisoprolol; Case-Control Studies; Digoxin; Disease Progression; Forced Expiratory Volume; Humans; Metoprolol; Nebivolol; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index; Verapamil; Vital Capacity | 2019 |
High-throughput quantification of ten antiarrhythmic drugs in human plasma using UPLC-MS/MS.
Topics: Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carvedilol; Chromatography, High Pressure Liquid; Diltiazem; Flecainide; High-Throughput Screening Assays; Humans; Lidocaine; Metoprolol; Propranolol; Reproducibility of Results; Sotalol; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Verapamil | 2019 |
Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring.
Topics: Amiodarone; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Computer Systems; Diltiazem; Drug Monitoring; Humans; Metoprolol; Pharmaceutical Preparations; Propafenone; Tandem Mass Spectrometry; Verapamil | 2020 |
Clinically Significant Bradycardia and Hypotension Following Consumption of Betel Leaf in a Patient Treated for Chronic Atrial Fibrillation.
Topics: Aged; Atrial Fibrillation; Bradycardia; Diabetes Mellitus, Type 2; Female; Humans; Hypotension; Metoprolol; Verapamil | 2023 |
Improved Cardiac Performance and Decreased Arrhythmia in Hypertrophic Cardiomyopathy With Non-β-Blocking R-Enantiomer Carvedilol.
Topics: Adrenergic beta-Antagonists; Animals; Arrhythmias, Cardiac; Cardiomyopathy, Hypertrophic; Carvedilol; Humans; Metoprolol; Mice; Myocytes, Cardiac; Receptors, Adrenergic; Ryanodine Receptor Calcium Release Channel; Verapamil | 2023 |