verapamil and methotrexate

verapamil has been researched along with methotrexate in 56 studies

Research

Studies (56)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (7.14)	18.7374
1990's	12 (21.43)	18.2507
2000's	21 (37.50)	29.6817
2010's	19 (33.93)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Belinsky, MG; Chen, ZS; Kruh, GD; Rea, PA; Zeng, H	1
Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA	1
Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL	1
Belinsky, MG; Chen, ZS; Hopper-Borge, E; Kotova, E; Kruh, GD; Shchaveleva, I	1
Bai, J; Goh, BC; Lai, L; Tan, TM; Yeo, HC	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Masseno, V; Muriithi, S; Nzila, A	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S	1
Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Campillo, NE; Guerra, A; Páez, JA	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Adile, AA; Bakhshinyan, D; Berger-Becvar, A; de Araujo, ED; Deininger, MW; Fishel, ML; Gawel, JM; Geletu, M; Grimard, ML; Gunning, PT; Heaton, WL; Konieczny, SF; Luchman, HA; O'Hare, T; Raouf, YS; Shah, F; Shouksmith, AE; Singh, SK; Venugopal, C; Weiss, S	1
Henderson, GB	1
Assaraf, YG; Schimke, RT; Sharma, RC	1
Henderson, GB; Strauss, BP	1
Haber, M; Kavallaris, M; Norris, MD; Pittman, SM; Reed, C; Stewart, BW	1
O'Leary, DF; Sirotnak, FM	1
Assaraf, YG; Molina, A; Schimke, RT; Sherwood, SW	1
Assaraf, YG; Molina, A; Schimke, RT	1
Arkin, H; Holland, JF; Kamen, BA; Ohnuma, T; Vallabhajosula, S	1
Cheng, YC; Ferguson, PJ	1
Gale, GR; Hynes, JB; Smith, AB	1
Boogaerts, MA; Van Acker, KL; Van Hove, LM	1
Audouin, J; Bernadou, A; Chauvenet, L; Ciaudo, M; Favier, R; Horellou, MH; Rossert, J; Samama, M	1
Boiocchi, M; Corona, G; Gigante, M; Toffoli, G	1
Alken, P; Köhrmann, KU; Kreukler, C; Nebe, T; Siegsmund, MJ; Steidler, A	1
Cowie, FJ; Pinkerton, CR; Pritchard-Jones, K; Renshaw, J	1
Anuszewska, EL; Koziorowska, JH	1
Drewe, J; Droulle, A; Fahr, A; Fricker, G; Gutmann, H; Miller, DS	1
Bickeböller, R; Dolderer, JH; Schoch, C; Schuldes, H; Woodcock, BG	1
Barge, RM; Honders, MW; Spoelder, HE; Veuger, MJ; Willemze, R	1
Canevari, S; D'Ascenzo, S; Dolo, V; Millimaggi, D; Miotti, S; Pavan, A; Violini, S	1
Baskiewicz-Masiuk, M; Gawronska-Szklarz, B; Machalinski, B; Pawlik, A	1
Baśkiewicz-Masiuk, M; Gawrońska-Szklarz, B; Machaliński, B; Pawlik, A; Safranow, K	1
Biswal, BK; Verma, RS	1
Carsetti, R; D'Amelio, R; Diamanti, AP; Germano, V; Giorda, E; Laganà, B; Podestà, E; Rosado, M; Scarsella, M	1
Bartolomeu, AR; da Silva, LM; de Oliveira, DE; Frión-Herrera, Y; Romagnoli, GG; Sforcin, JM	1
Ashrafi, H; Azadi, A; Moghaddam Panah, F; Pourtalebi Jahromi, L	1
Coyle, B; Grundy, RG; Jackson, HK; Kerr, ID; Kilday, JP; Liu, JF; Sabnis, DH; Storer, LCD	1

Reviews

2 review(s) available for verapamil and methotrexate

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

54 other study(ies) available for verapamil and methotrexate

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer research, 2001, Oct-01, Volume: 61, Issue:19 Topics: 3T3 Cells; Animals; ATP-Binding Cassette Transporters; Biological Transport; Drug Resistance, Multiple; Folic Acid; Humans; Leucovorin; Methotrexate; Mice; Multidrug Resistance-Associated Proteins; Osmolar Concentration; Polyglutamic Acid; Tritium	2001
Rational use of in vitro P-glycoprotein assays in drug discovery. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 299, Issue:2 Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera	2001
Cheminformatic models to predict binding affinities to human serum albumin. Journal of medicinal chemistry, 2001, Dec-06, Volume: 44, Issue:25 Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids	2001
Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Molecular pharmacology, 2003, Volume: 63, Issue:2 Topics: Biological Transport; Cells, Cultured; Cyclosporine; Estradiol; Glycocholic Acid; Humans; Kinetics; Leukotriene Antagonists; Leukotriene C4; Multidrug Resistance-Associated Proteins; Osmotic Pressure; Propionates; Quinolines; Recombinant Proteins; Transfection	2003
Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. The international journal of biochemistry & cell biology, 2004, Volume: 36, Issue:2 Topics: Adenosine Triphosphate; Anions; Antimetabolites, Antineoplastic; Benzbromarone; Biological Transport; Biological Transport, Active; Bridged Bicyclo Compounds; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Cyclic AMP; Cyclic GMP; Cyclooxygenase Inhibitors; Dinitrochlorobenzene; Drug Resistance; Estradiol; Glutathione; Humans; Indomethacin; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxygen; Phosphorylation; Thioguanine; Time Factors; Transfection; Verapamil	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7 Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorganic & medicinal chemistry, 2009, Oct-01, Volume: 17, Issue:19 Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship	2009
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20 Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. European journal of medicinal chemistry, 2010, Volume: 45, Issue:11 Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer. Journal of medicinal chemistry, 2019, 03-14, Volume: 62, Issue:5 Topics: Animals; Apoptosis; Benzamides; Cell Line, Tumor; Cell Proliferation; Coculture Techniques; Disease Models, Animal; Histone Deacetylase Inhibitors; Humans; Hydrocarbons, Fluorinated; Hydroxamic Acids; Mice; Pancreatic Neoplasms; Sulfonamides	2019
Separation and inhibitor specificity of a second unidirectional efflux route for methotrexate in L1210 cells. Biochimica et biophysica acta, 1992, Oct-05, Volume: 1110, Issue:2 Topics: Adenosine Triphosphate; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Leukemia L1210; Methotrexate; Mice; Probenecid; Prostaglandins A; Quinidine; Reserpine; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil; Vincristine	1992
A phenotype conferring selective resistance to lipophilic antifolates in Chinese hamster ovary cells. Cancer research, 1991, Jun-01, Volume: 51, Issue:11 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Cell Line; Cricetinae; Drug Resistance; Folic Acid Antagonists; Gene Amplification; Membrane Glycoproteins; Methotrexate; Phenotype; Pyrimidines; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Trimetrexate; Verapamil	1991
Evidence for cAMP and cholate extrusion in C6 rat glioma cells by a common anion efflux pump. The Journal of biological chemistry, 1991, Jan-25, Volume: 266, Issue:3 Topics: Animals; Antimycin A; Biological Transport, Active; Cholic Acids; Cyclic AMP; Glioma; Isoproterenol; Methotrexate; Probenecid; Prostaglandins A; Rats; Sulfobromophthalein; Tumor Cells, Cultured; Verapamil	1991
Phenotypic and cytogenetic analysis of atypical multidrug resistance in human leukaemic cells selected with methotrexate at high concentration. Cancer letters, 1990, Jun-15, Volume: 51, Issue:3 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Dactinomycin; Drug Resistance; Humans; Karyotyping; Leukemia; Membrane Glycoproteins; Methotrexate; Phenotype; Tumor Cells, Cultured; Verapamil; Vinblastine; Vincristine	1990
The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors. Cancer research, 1991, Mar-01, Volume: 51, Issue:5 Topics: Adenosine Triphosphate; Animals; Biological Transport; Energy Metabolism; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Probenecid; Sulfobromophthalein; Verapamil	1991
Flow cytometric characterization of antifolate resistance in cultured mammalian cells using fluoresceinated methotrexate and daunorubicin. Cancer research, 1990, Aug-15, Volume: 50, Issue:16 Topics: Animals; Cell Line; Colchicine; Cricetinae; Cricetulus; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Folic Acid Antagonists; Kinetics; Methotrexate; Ovary; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Verapamil	1990
Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. Journal of the National Cancer Institute, 1989, Feb-15, Volume: 81, Issue:4 Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line; Drug Resistance; Female; Genes; Humans; Methotrexate; Ovarian Neoplasms; Phenotype; Quinazolines; Quinidine; RNA, Messenger; Trimetrexate; Tumor Cells, Cultured; Verapamil	1989
Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate. Cancer research, 1989, Dec-01, Volume: 49, Issue:23 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Doxorubicin; Drug Resistance; Humans; In Vitro Techniques; Leukemia; Membrane Glycoproteins; Methotrexate; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured; Verapamil; Vincristine	1989
Transient protection of cultured human cells against antitumor agents by 12-O-tetradecanoylphorbol-13-acetate. Cancer research, 1987, Jan-15, Volume: 47, Issue:2 Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Etoposide; Humans; Methotrexate; Mitoxantrone; Nasopharyngeal Neoplasms; Tetradecanoylphorbol Acetate; Time Factors; Type C Phospholipases; Verapamil; Vincristine	1987
Effects of 5,8-dideazaisopteroylglutamate (IAHQ) on L1210 leukemia in mice when given alone and in combination with methotrexate, probenecid, or verapamil. Cancer chemotherapy and pharmacology, 1986, Volume: 18, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Folic Acid Antagonists; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Probenecid; Quinazolines; Time Factors; Verapamil	1986
Evaluation of flow cytometry for multidrug resistance detection in low resistance K562 cells using daunorubicin and monoclonal antibodies. Cytometry, 1993, Volume: 14, Issue:7 Topics: Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cyclosporine; Daunorubicin; Drug Resistance; Flow Cytometry; Gene Expression; Humans; Leukemia, Erythroblastic, Acute; Membrane Glycoproteins; Methotrexate; Neoplasm Proteins; Tumor Cells, Cultured; Verapamil; Vinblastine	1993
Peripheral-T-cell lymphoma with hemophagocytic histiocytosis localised to the bone marrow associated with inappropriate secretion of antidiuretic hormone. Leukemia & lymphoma, 1995, Volume: 19, Issue:5-6 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Bone Marrow Diseases; Cisplatin; Cyclophosphamide; Cytarabine; Dexamethasone; Disease Progression; Doxorubicin; Fatal Outcome; Female; Histiocytosis, Non-Langerhans-Cell; Humans; Ifosfamide; Inappropriate ADH Syndrome; Lymphoma, T-Cell, Peripheral; Methotrexate; Mitoguazone; Prednisone; Teniposide; Verapamil; Vincristine; Vindesine	1995
Inhibition of Pgp activity and cell cycle-dependent chemosensitivity to doxorubicin in the multidrug-resistant LoVo human colon cancer cell line. European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A, Issue:9 Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; G2 Phase; Humans; Methotrexate; Microscopy, Fluorescence; S Phase; Tumor Cells, Cultured; Verapamil	1996
Multidrug resistance in androgen-independent growing rat prostate carcinoma cells is mediated by P-glycoprotein. Urological research, 1997, Volume: 25, Issue:1 Topics: Androgens; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Fluorescent Dyes; Genes, MDR; Male; Methotrexate; Neoplasms, Hormone-Dependent; Paclitaxel; Prostatic Neoplasms; Rats; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil; Vinblastine	1997
Multidrug resistance modulation in rhabdomyosarcoma and neuroblastoma cell lines. International journal of oncology, 1998, Volume: 12, Issue:5 Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Small Cell; Cell Survival; Cisplatin; Cyclophosphamide; Cyclosporine; Doxorubicin; Drug Resistance, Multiple; Etoposide; Humans; Kinetics; Lung Neoplasms; Methotrexate; Neuroblastoma; Rhabdomyosarcoma; Time Factors; Tumor Cells, Cultured; Verapamil; Vincristine	1998
Adaptive response towards adriamycin in vitro: circumvention with verapamil. Mutation research, 1999, Dec-16, Volume: 431, Issue:1 Topics: Animals; Antineoplastic Agents; Calcium Channel Blockers; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Doxorubicin; Drug Combinations; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Inhibitory Concentration 50; Melanoma; Methotrexate; Tumor Cells, Cultured; Verapamil; Vinblastine	1999
P-glycoprotein- and mrp2-mediated octreotide transport in renal proximal tubule. British journal of pharmacology, 2000, Volume: 129, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Drug Resistance, Multiple; Fluorescent Dyes; In Vitro Techniques; Kidney Tubules, Proximal; Killifishes; Leukotriene C4; Methotrexate; Microscopy, Fluorescence; Octreotide; Time Factors; Verapamil	2000
Cytostatic sensitivity and MDR in bladder carcinoma cells: implications for tumor therapy. International journal of clinical pharmacology and therapeutics, 2000, Volume: 38, Issue:4 Topics: Antineoplastic Agents; Calcium Channel Blockers; Carcinoma, Transitional Cell; Cisplatin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Electron Spin Resonance Spectroscopy; Humans; Male; Methotrexate; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Verapamil	2000
Inactivation of deoxycytidine kinase and overexpression of P-glycoprotein in AraC and daunorubicin double resistant leukemic cell lines. Leukemia research, 2003, Volume: 27, Issue:5 Topics: 2-Chloroadenosine; Alternative Splicing; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Biological Transport; Buthionine Sulfoximine; Calcium Channel Blockers; Cytarabine; Daunorubicin; Decitabine; Deoxyadenosines; Deoxycytidine Kinase; DNA Mutational Analysis; DNA, Neoplasm; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glutathione; Humans; Idarubicin; Leukemia; Methotrexate; Neoplasm Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Verapamil	2003
Induction of a multifactorial resistance phenotype by high paclitaxel selective pressure in a human ovarian carcinoma cell line. Journal of experimental & clinical cancer research : CR, 2004, Volume: 23, Issue:1 Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Female; Flow Cytometry; Fluorouracil; Humans; Inhibitory Concentration 50; Methotrexate; Mitochondrial Proteins; Multidrug Resistance-Associated Proteins; Ovarian Neoplasms; Paclitaxel; Phenotype; Ribosomal Proteins; Saccharomyces cerevisiae Proteins; Tetrazolium Salts; Time Factors; Tubulin; Verapamil; Vinblastine	2004
Involvement of P-gp in the process of apoptosis in peripheral blood mononuclear cells. International immunopharmacology, 2005, Volume: 5, Issue:5 Topics: Adult; Antibodies, Monoclonal; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cortisone; Dexamethasone; Female; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Male; Methotrexate; Methylprednisolone; Middle Aged; Phytohemagglutinins; Verapamil	2005
Involvement of P-glycoprotein in the release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone. The Journal of pharmacy and pharmacology, 2005, Volume: 57, Issue:11 Topics: Anti-Inflammatory Agents; Antibodies, Monoclonal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Cytokines; Dexamethasone; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Interleukins; Leukocytes, Mononuclear; Methotrexate; Phytohemagglutinins; Tumor Necrosis Factor-alpha; Verapamil	2005
Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells. Journal of biochemistry, 2009, Volume: 146, Issue:5 Topics: Antibodies; Biological Transport; Buffers; Carrier Proteins; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Ions; Leukemia; Membrane Transport Proteins; Methotrexate; Mitomycin; Phosphates; Receptors, Cell Surface; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; Sulfasalazine; Sulfates; T-Lymphocytes; Time Factors; Verapamil	2009
Reversion of resistance to immunosuppressive agents in three patients with psoriatic arthritis by cyclosporine A: modulation of P-glycoprotein function. Clinical immunology (Orlando, Fla.), 2011, Volume: 138, Issue:1 Topics: Adult; Arthritis, Psoriatic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood Sedimentation; C-Reactive Protein; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cyclosporine; Drug Resistance; Female; Humans; Immunosuppressive Agents; Joints; Male; Methotrexate; Middle Aged; Rhodamine 123; Sulfasalazine; T-Lymphocytes; Treatment Outcome; Verapamil	2011
Combinatorial effects of geopropolis produced by Melipona fasciculata Smith with anticancer drugs against human laryngeal epidermoid carcinoma (HEp-2) cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2016, Volume: 81 Topics: Animals; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bees; Carboplatin; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Doxorubicin; Drug Therapy, Combination; Humans; L-Lactate Dehydrogenase; Laryngeal Neoplasms; Methotrexate; Propolis; Verapamil	2016
A mechanistic investigation on methotrexate-loaded chitosan-based hydrogel nanoparticles intended for CNS drug delivery: Trojan horse effect or not? International journal of biological macromolecules, 2019, Mar-15, Volume: 125 Topics: Animals; Brain; Chitosan; Drug Carriers; Drug Delivery Systems; Hydrogels; Methotrexate; Nanoparticles; Particle Size; Rats; Verapamil	2019
A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma. Scientific reports, 2019, 07-16, Volume: 9, Issue:1 Topics: ATP Binding Cassette Transporter, Subfamily B; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Child, Preschool; Drug Resistance, Neoplasm; Drug Synergism; Ependymoma; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Infant; Methotrexate; Neoplasm Invasiveness; Neoplastic Stem Cells; Prognosis; Survival Analysis; Up-Regulation; Vardenafil Dihydrochloride; Verapamil; Vincristine	2019