Compounds > verapamil

verapamil and methanethiosulfonate

verapamil has been researched along with methanethiosulfonate in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Clarke, DM; Loo, TW1
Bartlett, MC; Clarke, DM; Loo, TW4

Other Studies

5 other study(ies) available for verapamil and methanethiosulfonate

ArticleYear
Defining the drug-binding site in the human multidrug resistance P-glycoprotein using a methanethiosulfonate analog of verapamil, MTS-verapamil.
    The Journal of biological chemistry, 2001, May-04, Volume: 276, Issue:18

    Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cysteine; Drug Resistance, Multiple; Humans; Mesylates; Mutagenesis; Verapamil

2001
Permanent activation of the human P-glycoprotein by covalent modification of a residue in the drug-binding site.
    The Journal of biological chemistry, 2003, Jun-06, Volume: 278, Issue:23

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Cysteine; Humans; Kidney; Mesylates; Mutagenesis; Protein Structure, Tertiary; Verapamil

2003
Methanethiosulfonate derivatives of rhodamine and verapamil activate human P-glycoprotein at different sites.
    The Journal of biological chemistry, 2003, Dec-12, Volume: 278, Issue:50

    Topics: Adenosine Triphosphatases; ATP Binding Cassette Transporter, Subfamily B, Member 1; Benzimidazoles; Binding Sites; Biological Transport; Calcium Channel Blockers; Cell Line; Colchicine; Cysteine; Disulfides; DNA, Complementary; Dose-Response Relationship, Drug; Fluoresceins; Fluorescent Dyes; Histidine; Humans; Mesylates; Models, Biological; Models, Chemical; Mutation; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Rhodamines; Verapamil

2003
Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket.
    The Biochemical journal, 2006, Jun-15, Volume: 396, Issue:3

    Topics: Adenosine Triphosphatases; Amino Acid Sequence; Amino Acid Substitution; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Line; Colchicine; Cricetinae; Cyclosporine; Demecolcine; Disulfides; Dithiothreitol; Fluoresceins; Flupenthixol; Humans; Mesylates; Point Mutation; Protein Structure, Tertiary; Verapamil; Vinblastine

2006
Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket.
    The Biochemical journal, 2006, Oct-15, Volume: 399, Issue:2

    Topics: Adenosine Triphosphatases; Amino Acid Sequence; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Cell Membrane; Cells, Cultured; Cross-Linking Reagents; Cysteine; Disulfides; Enzyme Activation; Humans; Mesylates; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Secondary; Substrate Specificity; Vanadates; Verapamil

2006