verapamil has been researched along with loperamide in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (9.76) | 18.7374 |
| 1990's | 2 (4.88) | 18.2507 |
| 2000's | 14 (34.15) | 29.6817 |
| 2010's | 20 (48.78) | 24.3611 |
| 2020's | 1 (2.44) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Huang, L; Humphreys, JE; Morgan, JB; Polli, JW; Serabjit-Singh, CS; Webster, LO; Wring, SA | 1 |
| Adachi, Y; Sugiyama, Y; Suzuki, H | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Cianchetta, G; Cruciani, G; Fravolini, A; Giesing, D; Singleton, RW; Vaz, RJ; Wildgoose, M; Zhang, M | 1 |
| Cai, W; Hao, Y; Hu, P; Ma, D; Pan, H; Xie, X; Yu, AD; Yu, J; Yuan, J; Zhang, L; Zhu, H | 1 |
| Cuddon, P; Fleming, A; Floto, RA; Goldsmith, P; Jahreiss, L; O'Kane, CJ; Pask, D; Rubinsztein, DC; Saiki, S; Sarkar, S; Siddiqi, FH; Ttofi, EK; Williams, A | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Gozalbes, R; Pineda-Lucena, A | 1 |
| Chen, X; Lin, X; Skolnik, S; Wang, J | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Brouillette, WJ; Brown, GB; Zha, C | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Diener, M; Knobloch, SF; Rummel, W | 1 |
| Culver, PJ; Rattan, S | 1 |
| Ito, K; Izumi, Y; Kato, H; Miyakawa, H | 1 |
| Bando, K; Honda, H; Iwata, T; Takagi, S | 1 |
| Enigbokan, MA; Preston, J; Thompson, JO; West, D | 1 |
| Epple, HJ; Fromm, M; Riecken, EO; Schulzke, JD | 1 |
| Crowe, A; Wong, P | 1 |
| Dagenais, C; Graff, CL; Pollack, GM | 1 |
| Christians, U; Elkiweri, IA; Henthorn, TK; Ng, KY; Tissot van Patot, MC; Zhang, YL | 1 |
| Pollack, GM; Zhao, R | 1 |
| Hammarlund-Udenaes, M; Syvänen, S | 1 |
| Bhulani, NN; Gilani, AH; Khan, SH; Shah, AJ; Ur Rehman, N | 1 |
| Kataoka, M; Masaoka, Y; Sakuma, S; Yamashita, S; Yokoyama, T | 1 |
| Amano, N; Hirabayashi, H; Moriwaki, T; Sugimoto, H | 1 |
| Eriksson, J; Syvänen, S | 1 |
| Achilli, TM; McCalla, S; Meyer, J; Morgan, JR; Tripathi, A | 1 |
| Gilani, AH; Mandukhail, SR; Rizwani, GH; Shareef, H; Watanabe, N | 1 |
| Bauer, F; Erker, T; Filip, T; Kuntner, C; Langer, O; Löscher, W; Mairinger, S; Müller, M; Pahnke, J; Römermann, K; Sauberer, M; Stanek, J; Traxl, A; Wanek, T | 1 |
| Akazawa, T; Ohtsuki, S; Tachikawa, M; Terasaki, T; Uchida, Y | 1 |
| Badaoui, M; Dickson, CJ; Hornak, V; Kells, A; Molteni, C; Rosta, E | 1 |
| Masdeu, JC; Pascual, B; Rostomily, RC; Turkheimer, F; Veronese, M; Zanotti-Fregonara, P | 1 |
| Anoshchenko, O; Storelli, F; Unadkat, JD | 1 |
4 review(s) available for verapamil and loperamide
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
Using PET studies of P-gp function to elucidate mechanisms underlying the disposition of drugs.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Brain Diseases; Carbon Radioisotopes; Humans; Loperamide; Positron-Emission Tomography; Radioactive Tracers; Verapamil | 2010 |
Advances in PET imaging of P-glycoprotein function at the blood-brain barrier.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Carbon Radioisotopes; Central Nervous System Diseases; Humans; Loperamide; Positron-Emission Tomography; Radiopharmaceuticals; Verapamil | 2013 |
37 other study(ies) available for verapamil and loperamide
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Rational use of in vitro P-glycoprotein assays in drug discovery.
Topics: Adenosine Triphosphatases; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cells, Cultured; Chromatography, Liquid; Enzyme Inhibitors; Fluoresceins; Fluorescent Dyes; Humans; Mass Spectrometry; Pharmacology; Spodoptera | 2001 |
Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein.
Topics: Adenosine Triphosphate; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Caco-2 Cells; Cell Membrane Permeability; Dose-Response Relationship, Drug; Humans; Hydrolysis; LLC-PK1 Cells; Male; Mice; Mice, Knockout; Models, Biological; Pharmaceutical Preparations; Swine; Tissue Distribution; Transfection | 2001 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Fluoresceins; Fluorescent Dyes; Humans; Models, Molecular; Multivariate Analysis; Permeability; Quantitative Structure-Activity Relationship | 2005 |
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; Glioblastoma; Green Fluorescent Proteins; Humans; Intracellular Membranes; Loperamide; Microtubule-Associated Proteins; Mycotoxins; Peptides; Phagosomes; Phosphatidylinositol Phosphates; Pimozide; Protein Kinases; Recombinant Fusion Proteins; Sirolimus; Small Molecule Libraries; TOR Serine-Threonine Kinases; Trifluoperazine; Zinc Fingers | 2007 |
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway.
Topics: Animals; Autophagy; Calcium Channels, L-Type; Clonidine; Cyclic AMP; Humans; Huntington Disease; Imidazoline Receptors; Minoxidil; Protein Kinases; Signal Transduction; TOR Serine-Threonine Kinases; Type C Phospholipases; Verapamil | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
QSAR-based solubility model for drug-like compounds.
Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water | 2010 |
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model.
Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity | 2011 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands.
Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Action of loperamide on neuronally mediated and Ca2+- or cAMP-mediated secretion in rat colon.
Topics: Animals; Calcium; Carbachol; Colforsin; Colon; Cyclic AMP; Electric Stimulation; In Vitro Techniques; Intestinal Mucosa; Loperamide; Male; Morphine; Neurons; Piperidines; Rats; Rats, Inbred Strains; Trifluoperazine; Verapamil | 1988 |
Influence of loperamide on the internal anal sphincter in the opossum.
Topics: Anal Canal; Animals; Drug Interactions; Electric Stimulation; Female; Isoproterenol; Loperamide; Male; Naloxone; Nicotine; Opossums; Piperidines; Pressure; Rectum; Spinal Nerve Roots; Verapamil | 1987 |
Requirement of extracellular Ca2+ after tetanus for induction of long-term potentiation in guinea pig hippocampal slices.
Topics: Animals; Calcium; Electric Stimulation; Electrophysiology; Evoked Potentials; Guinea Pigs; Hippocampus; Loperamide; Verapamil | 1987 |
Comparative effects of loperamide hydrochloride on prostaglandin E1-induced contraction in isolated fundus and ileum of guinea pigs.
Topics: Alprostadil; Animals; Calcium Chloride; Gastric Fundus; Guinea Pigs; Ileum; In Vitro Techniques; Isometric Contraction; Loperamide; Male; Muscle Contraction; Muscle, Smooth; Peristalsis; Verapamil | 1994 |
Calmodulin inhibitors and calcium channel blockers influence dideoxycytidine renal excretion.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium-Transporting ATPases; Calmodulin; Kidney Tubules; Loperamide; Male; Metabolic Clearance Rate; Mice; Trifluoperazine; Verapamil; Zalcitabine | 1995 |
Antisecretory effect of loperamide in colon epithelial cells by inhibition of basolateral K+ conductance.
Topics: Antidiarrheals; Calcium Channel Blockers; Calmodulin; Carbachol; Chlorides; Cholinergic Agonists; Colforsin; Colon; Drug Evaluation, Preclinical; Enterocytes; HT29 Cells; Humans; Intestinal Mucosa; Loperamide; Naloxone; Narcotic Antagonists; Potassium Channels; Signal Transduction; Time Factors; Trifluoperazine; Verapamil | 2001 |
Potential roles of P-gp and calcium channels in loperamide and diphenoxylate transport.
Topics: Antidiarrheals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Calcium Channel Blockers; Calcium Channels; Cyclosporine; Cyclosporins; Diphenoxylate; Drug Interactions; Humans; Loperamide; Narcotics; Probenecid; Sulfinpyrazone; Verapamil | 2003 |
Variable modulation of opioid brain uptake by P-glycoprotein in mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; Benzomorphans; Biological Transport; Brain; Drug Interactions; Fentanyl; Loperamide; Meperidine; Methadone; Mice; Narcotics; Quinidine; Time Factors; Verapamil | 2004 |
Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats.
Topics: Analgesics, Opioid; Animals; ATP Binding Cassette Transporter, Subfamily B; Binding, Competitive; Brain; Electroencephalography; Fentanyl; Infusions, Intravenous; Loperamide; Lung; Male; Models, Biological; Naloxone; Organic Anion Transporters; Pravastatin; Rats; Rats, Sprague-Dawley; Tissue Distribution; Verapamil | 2009 |
Regional differences in capillary density, perfusion rate, and P-glycoprotein activity: a quantitative analysis of regional drug exposure in the brain.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Capillaries; Colchicine; Dose-Response Relationship, Drug; Infusions, Subcutaneous; Inulin; Least-Squares Analysis; Linear Models; Loperamide; Mice; Mice, Inbred Strains; Mice, Knockout; Microdissection; Perfusion; Quinidine; Regional Blood Flow; Substrate Specificity; Verapamil | 2009 |
Calcium channel blocking activity of Mentha longifolia L. explains its medicinal use in diarrhoea and gut spasm.
Topics: Animals; Antidiarrheals; Calcium; Calcium Channel Blockers; Castor Oil; Cations; Diarrhea; Jejunum; Loperamide; Mentha; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Parasympatholytics; Phytotherapy; Plant Extracts; Potassium; Rabbits; Verapamil | 2010 |
Estimation of P-glycoprotein-mediated efflux in the oral absorption of P-gp substrate drugs from simultaneous analysis of drug dissolution and permeation.
Topics: Algorithms; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Drug Interactions; Erythromycin; Gene Expression; Glycerol; Humans; Intestinal Absorption; Loperamide; Models, Biological; Pharmaceutical Preparations; Propanolamines; Puromycin; Quinidine; Saquinavir; Solubility; Surface-Active Agents; Terfenadine; Verapamil; Vinblastine | 2011 |
Retrospective analysis of P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Drug Interactions; Humans; LLC-PK1 Cells; Loperamide; Quinolines; Swine; Verapamil | 2013 |
Multilayer spheroids to quantify drug uptake and diffusion in 3D.
Topics: ATP Binding Cassette Transporter, Subfamily B; Carbenoxolone; Cell Line; Cell Line, Tumor; Cyclosporine; Diffusion; Fluoresceins; HEK293 Cells; Humans; Loperamide; MCF-7 Cells; Pharmaceutical Preparations; Spheroids, Cellular; Verapamil | 2014 |
Studies on antidiarrhoeal, antispasmodic and bronchodilator activities of Operculina turpethum Linn.
Topics: Animals; Antidiarrheals; Asthma; Bronchodilator Agents; Calcium; Calcium Channel Blockers; Carbachol; Castor Oil; Convolvulaceae; Diarrhea; Female; Guinea Pigs; Jejunum; Loperamide; Male; Mice, Inbred BALB C; Parasympatholytics; Phytotherapy; Plant Extracts; Potassium; Rabbits; Trachea; Verapamil | 2014 |
Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Brain; Calcium Channel Blockers; Carbon Radioisotopes; Drug Interactions; Female; Humans; Loperamide; Mice; Mice, Inbred C57BL; Mice, Knockout; Positron-Emission Tomography; Radiopharmaceuticals; Verapamil | 2015 |
Quantitative Targeted Absolute Proteomics of Transporters and Pharmacoproteomics-Based Reconstruction of P-Glycoprotein Function in Mouse Small Intestine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Sub-Family B Member 4; Dexamethasone; Digoxin; Duodenum; Ileum; Intestinal Absorption; Intestine, Small; Jejunum; Loperamide; Mice; Mice, Knockout; Proteomics; Quinidine; Verapamil; Vinblastine | 2016 |
Calculating Kinetic Rates and Membrane Permeability from Biased Simulations.
Topics: Cell Membrane Permeability; Chlorpromazine; Desipramine; Domperidone; Kinetics; Labetalol; Lipid Bilayers; Loperamide; Molecular Dynamics Simulation; Molecular Structure; Propranolol; Thermodynamics; Verapamil | 2018 |
The validity of
Topics: Animals; Biomarkers; Biopsy; Blood-Brain Barrier; Brain; Brain Neoplasms; Carbazoles; Fluorine Radioisotopes; Fluorodeoxyglucose F18; Genotype; Humans; Indoles; Inflammation; Ligands; Loperamide; Multiple Sclerosis; Positron-Emission Tomography; Protein Binding; Purines; Receptors, GABA; Reproducibility of Results; Verapamil | 2019 |
Successful Prediction of Human Steady-State Unbound Brain-to-Plasma Concentration Ratio of P-gp Substrates Using the Proteomics-Informed Relative Expression Factor Approach.
Topics: Algorithms; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Brain Chemistry; Dogs; Endothelial Cells; Extracellular Fluid; Forecasting; Gene Expression Regulation; Humans; Loperamide; Madin Darby Canine Kidney Cells; Metoclopramide; Positron-Emission Tomography; Proteomics; Verapamil | 2021 |