verapamil has been researched along with indomethacin in 222 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 75 (33.78) | 18.7374 |
| 1990's | 64 (28.83) | 18.2507 |
| 2000's | 45 (20.27) | 29.6817 |
| 2010's | 36 (16.22) | 24.3611 |
| 2020's | 2 (0.90) | 2.80 |
| Authors | Studies |
|---|---|
| Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET | 1 |
| Lüllmann, H; Timmermans, PB; Weikert, GM; Ziegler, A | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Hwang, KK; Mandagere, AK; Thompson, TN | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Faassen, F; Spanings, H; Vogel, G; Vromans, H | 1 |
| Bai, J; Goh, BC; Lai, L; Tan, TM; Yeo, HC | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Caron, G; Ermondi, G | 1 |
| Dansette, PM; Fontana, E; Poli, SM | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Gütschow, M; Häcker, HG; Leyers, S; Wiendlocha, J; Wiese, M | 1 |
| He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Sun, Y; Yan, Z | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Du-Cuny, L; Mash, EA; Meuillet, EJ; Moses, S; Powis, G; Song, Z; Zhang, S | 1 |
| Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S | 1 |
| Conradi, R; Lee, PH; Shanmugasundaram, V | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Avdeef, A; Tam, KY | 1 |
| Cheung, CC; Fung, KP; Lai, PB; Lee, WY; Liu, KW; Wong, J; Yeung, JH | 1 |
| Baumert, C; Coburger, C; Hilgeroth, A; Krug, M; Lage, H; Molnár, J; Seifert, M; Wollmann, J | 1 |
| Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Sen, S; Sinha, N | 1 |
| Bönisch, H; Haenisch, B; Mayer, R; Müller, CE; Müller, H; Pajeva, IK; Pick, A; Weigt, M; Wiese, M | 1 |
| Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K | 1 |
| Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A | 1 |
| Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Abe, H; Araki, T; Arisawa, M; Ito, M; Ito, Y; Kasaya, Y; Nakamura, T; Obata, T; Sasaki, A; Sasaki, T; Shuto, S; Yamamoto, K; Yamano, A | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Artursson, P; Mateus, A; Matsson, P | 1 |
| Augustijns, P; De Coen, LM; Jatczak, M; Keemink, J; Muylaert, K; Stevens, CV; Wuyts, B | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Esaki, T; Kawashima, H; Komura, H; Kuroda, M; Mizuguchi, K; Natsume-Kitatani, Y; Ohashi, R; Watanabe, R | 1 |
| Béguin, F | 1 |
| Haslam, RJ; Lynham, JA | 2 |
| Mosler, KH | 1 |
| Dietrich, JW; Duffield, R | 1 |
| Duthie, HL; Kirk, D | 1 |
| Carmignani, M; Porcelli, G; Volpe, AR | 1 |
| Haught, WH; Lawson, DL; Mehta, JL; Yang, BC | 1 |
| Bousser, MG; Tehindrazanarivelo, AD; Visy, JM | 1 |
| Achmad, TH; Rao, GS | 1 |
| Deyrup-Olsen, I; Louie, H; Luchtel, DL; Martin, AW | 1 |
| Gaginella, TS; Gullikson, GW; Moummi, C | 1 |
| Franz, DR; Robinson, CP | 1 |
| Rice, CD; Weeks, BA | 1 |
| Harmeyer, J; Kaune, R; Schröder, B | 1 |
| Souhrada, JF; Souhrada, M | 1 |
| Agarwal, KC; Tzanakakis, GN; Veronikis, DK; Vezeridis, MP | 1 |
| Cóte, D; Ksander, G; Levens, NR | 1 |
| Ganguly, NK; Khullar, M; Khurana, S; Panigrahi, D; Walia, BN | 1 |
| Diener, M; Döring, A; Rummel, W | 1 |
| Hata, Y; Hiraishi, H; Mutoh, H; Ota, S; Sugimoto, T; Terano, A; Tsukahara, H | 1 |
| Bassett, AH; el Nahas, AM; Le Carpentier, JE; Wight, JP | 1 |
| Beubler, E; Hinterleitner, T; Horina, G | 1 |
| Firth, JD | 1 |
| Allen, CN; Gray, TJ; Harpur, ES; Hirst, BH; Simmons, NL | 1 |
| Danilenko, MP; Parubets, IA; Yesirev, OV | 1 |
| Dorigo, O; Kübler, W; Neumann, FJ; Parekh, N; Steinhausen, M; Tiefenbacher, C; Tillmanns, H; Zimmermann, R | 1 |
| Balkowski, G; Harlacher, R; Langhans, W; Scharrer, E | 1 |
| Ishizaki, M | 1 |
| Haynes, DH; Jy, W | 1 |
| Dasarathy, Y; Fanburg, BL | 1 |
| Conlon, JM; Katsoulis, S | 1 |
| Donnelly, WH; Lawson, DL; Mehta, JL; Nichols, WW; Saldeen, TG | 1 |
| Beubler, E; Bukhave, K; Kollar, G; Rask-Madsen, J; Saria, A | 1 |
| Bertaccini, G; Coruzzi, G; Montanari, C; Poli, E | 1 |
| Baba, K; Kawanishi, M; Satake, T; Tomita, T | 1 |
| Baba, K; Ito, M; Satake, T; Takagi, K; Tomita, T | 1 |
| Braquet, P; Chabrier, PE; Lagente, V; Mencia-Huerta, JM | 1 |
| Harlacher, R; Langhans, W; Scharrer, E | 1 |
| Kane, KA; Kwan, YW; Wadsworth, RM | 1 |
| Dohi, T; Morita, K; Tsujimoto, A; Yamada, S | 1 |
| Karaki, H; Satoh, T | 1 |
| Azuma, H; Nakajima, T; Satoh, A; Sekizaki, S | 1 |
| Fazackerley, J; Pleuvry, BJ | 1 |
| Karaki, H; Nagase, H | 1 |
| Brandes, LJ; Glavin, GB | 1 |
| Dawson, AP; Hill, CE; Olson, MS; Pryor, JS | 1 |
| Kohút, A; Mirossay, L; Nicák, A | 1 |
| Bruserud, O; Thorsby, E | 1 |
| Beubler, E; Bukhave, K; Rask-Madsen, J | 1 |
| Filep, J; Földes-Filep, E; Frölich, JC | 1 |
| Farrukh, IS; Gurtner, GH; Michael, JR | 1 |
| Arroyave, JL; Gonzalez-Crussi, F; Hsueh, W | 1 |
| Cheng, HY; Donowitz, M; Sharp, GW | 1 |
| Dorman, RV; Schwartz, MA; Terrian, DM | 1 |
| Boiardi, A; Bussone, G; Gemma, M; Peccarisi, C; Porta, E | 1 |
| Chen, IJ; Teng, CM; Yeh, HI | 1 |
| Northover, AM; Northover, BJ | 1 |
| Barros, EJ; Boim, MA; Draibe, SA; Ramos, OL; Schor, N; Sigulem, D | 1 |
| László, A; Monos, E; Nádasy, GL; Zsolnai, B | 1 |
| Northover, AM | 1 |
| Glusa, E; Markwardt, F | 1 |
| Ivey, KJ; Razandi, M; Romano, M | 1 |
| Cortijo, J; Esplugues, J; Morcillo, EJ; Ortiz, JL; Perpiñá, M; Sanz, C | 1 |
| Ajzen, H; Barros, EJ; Boim, MA; Ramos, OL; Schor, N | 1 |
| Booker, BB; Galla, JH; Luke, RG | 1 |
| Maruta, K; Osa, T | 1 |
| Davoust, N; Mårtensson, L | 1 |
| Herreros, R; Huidobro-Toro, JP; Pinto-Corrado, A | 1 |
| Northover, BJ | 1 |
| Kimura, T; Satoh, S | 1 |
| Belin, J; Khan, SN; Sidey, M; Smith, AD; Zilkha, KJ | 1 |
| Gairard, A; Schleiffer, R | 1 |
| Clark, JS; Jubb, SN; Maloney, PJ; Young, JM | 1 |
| Hasegawa, J; Kasai, M; Yamada, I | 1 |
| Shimazu, T; Usami, M | 1 |
| Murakami, H; Ohmura, E; Shizume, K; Tsushima, T; Wakai, K | 1 |
| Gagnon, G; Regoli, D; Rioux, F | 1 |
| Buemi, M; Ciraolo, O; Costa, G; De Pasquale, R; Frisina, N; Lasco, A; Nicita Mauro, V | 1 |
| Eichner, RD; Hunt, NH; Lim, LK; Weidemann, MJ | 1 |
| Hunt, NH; Lim, LK; Weidemann, MJ | 1 |
| Huang, TF; Ouyang, C | 1 |
| Busse, R; Förstermann, U; Matsuda, H; Pohl, U | 1 |
| Gracián Gómez, M; Guía Torrent, JM; Rodríguez Caamaño, J | 1 |
| Abe, M; Furukawa, T | 1 |
| Lee, TC; Malone, B; Snyder, F | 1 |
| Burka, JF; Saad, MH | 1 |
| Goldenberg, MM; Meurer, RD | 1 |
| Dahl, ML; Uotila, P | 1 |
| Myers, A; Ramey, E; Ramwell, P | 1 |
| Koren, G; MacLeod, SM; Soldin, S | 1 |
| Anderson, WH; Krzanowski, JJ; Polson, JB; Szentivanyi, A | 1 |
| Berl, T | 1 |
| Jacobi, H; Jentzsch, KR; Lüdtke, W; Schwarz, H | 1 |
| Chahine, RA; Fuller, CM; Ishimori, T; Luchi, RJ; Mokotoff, D; Nahormek, P; Nitishin, A; Raizner, AE; Verani, M | 1 |
| Komiyama, H; Kozuka, H; Matsumoto, M; Miyahara, T; Miyanishi, A; Nagai, M; Takata, M; Takata, S; Xue-Ya, W; Yokoyama, K | 1 |
| Bozhko, AP; Solodkov, AP | 1 |
| al-Bekairi, AM; al-Rajhi, AM; Tariq, M | 1 |
| Ganbo, T; Hisamatsu, K; Inoue, H; Kikushima, K; Kou, J; Kozuka, Y; Mizukoshi, A; Murakami, Y | 1 |
| Brito, G; Bustamante, S; Morales, MA; Paeile, C; Ponce, H; Silva, A | 1 |
| Li, ZY; Lian, EC; Yu, TF | 1 |
| Soper, BD; Tepperman, BL | 1 |
| Gutiérrez-Cabano, CA | 2 |
| Lasova, LS; Mutafova-Yambolieva, VN; Venkova, KM | 1 |
| Altura, BM; Altura, BT; He, GQ; Zhang, A | 1 |
| Bozhko, AP; Rodionov, IuIa; Shebeko, VI; Solodkov, AP | 1 |
| DeFrancisis, M; Fuhrman, BP; Howland, DF; Venkataraman, ST | 1 |
| Arnould, T; Dieu, M; Knott, I; Michiels, C; Remacle, J | 1 |
| Galle, J; Schenck, I; Schollmeyer, P; Wanner, C | 1 |
| Eguchi, K; Fukuda, T; Ida, H; Ishikawa, N; Kawabe, Y; Kawakami, A; Nakashima, M; Sakai, M; Sakito, S; Terada, K | 1 |
| Cortijo, J; De Diego, A; Esplugues, J; Morcillo, EJ; Perpiñá, M; Villagrasa, V | 1 |
| el-Tahtawy, AA; Jackson, AJ; Ludden, TM | 1 |
| Buck, MG; Goswami, S; Maayani, S; Marom, Z; Rienzi, N; Schachter, EN; Zuskin, E | 1 |
| De Marco, L; Masotti, A; Mazzucato, M; Pareti, FI; Pradella, P | 1 |
| Armour, CL; Black, JL; McKay, KO | 1 |
| Dazy, AC; Diogène, G; Marano, F; Venant, A | 1 |
| Abe, A; Hori, M; Karaki, H; Kinoshita, M; Mitsui-Saito, M; Ozaki, H; Uehigashi, Y | 1 |
| Coleman, ES; Sartin, JL | 1 |
| Alder, VA; Cringle, SJ; Su, EN; Yu, DY; Yu, PK | 1 |
| Kato, S; Takehara, K; Takeuchi, K; Yagi, K | 1 |
| Ganguly, NK; Kaur, T; Singh, S; Verma, M | 1 |
| Azizova, OA; Vlasova, II | 1 |
| Gilani, AH; Rashid, F; Saeed, SA; Shah, BH | 1 |
| Hu, DH; Ma, CT | 1 |
| Dhawan, V; Ganguly, NK; Kaur, T; Singh, S | 1 |
| Borda, ES; Rumi, L; Sales, ME; Sterin-Borda, L; Tenenbaum, A | 1 |
| Kankaanranta, H; Li, L; Paakkari, I; Vaali, K; Vapaatalo, H | 1 |
| Kang, BS; Lee, YH; Seo, JH | 1 |
| Annaert, P; Augustijns, P; De Clercq, E; Kinget, R; Naesens, L; Van den Mooter, G; Van Gelder, J | 1 |
| Kokoska, ER; Miller, TA; Smith, GS | 1 |
| Ateş, S; Kaygisiz, Z | 1 |
| Borda, E; Busch, L; Wald, M | 1 |
| Courtois, A; Fardel, O; Guillouzo, A; Payen, L; Vernhet, L | 1 |
| Aono, T; Kunikata, K; Tokumura, A; Yamano, S | 1 |
| Ito, Y; Yamaki, K | 1 |
| Abassi, ZA; Brodsky, S; Hoffman, A; Ramadan, R; Winaver, J | 1 |
| Carrón, R; López-Hernández, FJ; Montero, MJ | 1 |
| Albano, O; Bassi, A; Causarano, V; Centonze, A; Centonze, V; Dalfino, L | 1 |
| Bevers, EM; Comfurius, P; Dekkers, DW; van Gool, RG; Zwaal, RF | 1 |
| Appert, HE; Howard, JM; Iwamura, T; Liu, B; Staren, ED | 1 |
| Ding, Y; Liu, H; Ma, Y; Qiu, X; Qu, S; Wei, Y; Zhang, Y | 1 |
| Hanif, S; Khan, FL; Rahman, HB; Rahman, IH; Rasheed, H; Saeed, SA; Shah, BH; Shariff, AH | 1 |
| Bandi, N; Kompella, UB | 1 |
| Crowe, A | 1 |
| Boes, CJ; Goadsby, PJ; Matharu, MS | 1 |
| Lisotto, C; Maggioni, F; Mainardi, F; Zanchin, G | 1 |
| Bähr, O; Duffner, F; Meyermann, R; Rieger, J; Weller, M; Wick, W | 1 |
| Bacchelli, B; Boraldi, F; Croce, MA; Garcia Fernandez, MI; Gheduzzi, D; Pasquali Ronchetti, I; Quaglino, D; Tiozzo, R | 1 |
| Achakzai, MI; Ali, R; Connor, JD; Fecto, FA; Gilani, AU; Rasheed, H; Saeed, SA | 1 |
| Rasheed, H; Saeed, SA | 1 |
| Jacob, S; Rajabally, YA | 1 |
| Rozen, TD | 1 |
| Bertelsen, KM; Greenblatt, DJ; von Moltke, LL | 1 |
| Chien, S; Lay, CS; Lee, FY; Lee, SD; May, CM; Sinchon, S; Tsai, YT | 1 |
| Arruebo, MP; Grasa, L; Murillo, MD; Plaza, MA | 1 |
| Cao, LH; Choi, DH; Kang, DG; Kim, JS; Kim, SJ; Lee, H; Lee, HS; Lee, JK | 1 |
| Biran, I; Gotkine, M; Steiner, I | 1 |
| Bridges, CC; Campos, I; Costa, F; Gonçalves, P; Keating, E; Lemos, C; Martel, F; Smith, SB | 1 |
| Rosenberg-Nordmann, M; Sprenger, T; Tölle, TR | 1 |
| Cohen, AS; Goadsby, PJ | 1 |
| Bishop, B; Conklin, DJ; Hargens, AR; Lillywhite, HB; Olson, KR | 1 |
| Gilani, AH; Shah, AJ | 1 |
| Grosberg, BM; Lipton, RB; Robbins, MS | 1 |
| Chang, IH; Han, JH; Kim, HJ; Kim, W; Lee, MY; Lee, SY; Myung, SC | 1 |
| Bertelli, E; Dragoni, S; Franco, G; Frosini, M; Gori, M; Possidente, M; Teodori, E; Valoti, M | 1 |
| Kulkarni, MG; Muthusamy, R | 1 |
| Khan, AU; Murugan, DD; Mustafa, MR | 1 |
| El-Azab, MF; Fouda, A; Moustafa, YM | 1 |
| Aihara, E; Hentz, CL; Korman, AM; Montrose, MH; Perry, NPJ; Prasad, V; Shull, GE | 1 |
| Alexander, SP; Garle, MJ; Randall, MD; Roberts, RE; Wong, PS | 1 |
| Lucetti, LT; Magalhães, PJ; Ribeiro-Filho, HV; Vasconcelos, TB | 1 |
| Chaudhry, B; Egginton, S; Glen, KE; Hall-Jones, J; Hussain, A; Syeda, F | 1 |
| Byrne, S; Lambru, G | 1 |
| Babić, I; Bojić, M; Duka, I; Gojčeta, K; Jukić, I; Maleš, Ž; Rimac, H; Zadro, R | 1 |
| Basir, SF; Khan, LA; Wani, SA | 1 |
5 review(s) available for verapamil and indomethacin
| Article | Year |
|---|---|
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.
Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic | 2005 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
[Recent advances and future perspectives in the medical treatment of cardiopathies in children].
Topics: Child; Ductus Arteriosus, Patent; Heart Defects, Congenital; Heart Failure; Humans; Hypoxia; Indomethacin; Infant, Low Birth Weight; Infant, Newborn; Oxygen Inhalation Therapy; Prostaglandins; Tachycardia, Paroxysmal; Vasodilator Agents; Verapamil | 1984 |
[Trigeminal autonomic cephalgias: diagnostic and therapeutic implications].
Topics: Administration, Intranasal; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cluster Headache; Diagnosis, Differential; Humans; Indomethacin; Injections, Subcutaneous; Magnetic Resonance Imaging; Oxazolidinones; Paroxysmal Hemicrania; Serotonin Receptor Agonists; Sumatriptan; SUNCT Syndrome; Time Factors; Trigeminal Autonomic Cephalalgias; Tryptamines; Vasodilator Agents; Verapamil | 2007 |
[Pathophysiology and treatment of trigeminal autonomic cephalalgias].
Topics: Administration, Oral; Amines; Analgesics; Anesthetics, Local; Anti-Inflammatory Agents, Non-Steroidal; Cluster Headache; Cyclohexanecarboxylic Acids; Diagnosis, Differential; Female; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Indomethacin; Lamotrigine; Lidocaine; Male; Methysergide; Nociceptors; Oxygen Inhalation Therapy; Paroxysmal Hemicrania; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan; SUNCT Syndrome; Topiramate; Triazines; Trigeminal Autonomic Cephalalgias; Trigeminal Nerve; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 2008 |
1 trial(s) available for verapamil and indomethacin
| Article | Year |
|---|---|
Evaluation of bioequivalence of highly variable drugs using Monte Carlo simulations. I. Estimation of rate of absorption for single and multiple dose trials using Cmax.
Topics: Absorption; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biological Availability; Calcium Channel Blockers; Computer Simulation; Delayed-Action Preparations; Humans; Indomethacin; Intestinal Absorption; Kinetics; Male; Middle Aged; Monte Carlo Method; Therapeutic Equivalency; Verapamil | 1995 |
216 other study(ies) available for verapamil and indomethacin
| Article | Year |
|---|---|
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium | 1985 |
Accumulation of drugs by guinea pig isolated atria. Quantitative correlations.
Topics: Animals; Chemistry, Pharmaceutical; Electric Stimulation; Guinea Pigs; Humans; In Vitro Techniques; Kinetics; Myocardium; Pharmaceutical Preparations; Protein Binding; Serum Albumin; Solubility; Time Factors | 1980 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Active transport of fluorescent P-glycoprotein substrates: evaluation as markers and interaction with inhibitors.
Topics: 3T3 Cells; Adrenergic Uptake Inhibitors; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Biological Transport, Active; Cell Line; Cell Separation; Cell Survival; Flow Cytometry; Fluorescent Dyes; Humans; Inhibitory Concentration 50; Mice; Protein Binding; Reserpine; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2001 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Graphical model for estimating oral bioavailability of drugs in humans and other species from their Caco-2 permeability and in vitro liver enzyme metabolic stability rates.
Topics: Administration, Oral; Animals; Biological Availability; Caco-2 Cells; Dogs; Guinea Pigs; Humans; In Vitro Techniques; Inactivation, Metabolic; Liver; Microsomes, Liver; Models, Biological; Permeability; Pharmacokinetics; Rats; Species Specificity | 2002 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport | 2003 |
Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione.
Topics: Adenosine Triphosphate; Anions; Antimetabolites, Antineoplastic; Benzbromarone; Biological Transport; Biological Transport, Active; Bridged Bicyclo Compounds; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Line; Cyclic AMP; Cyclic GMP; Cyclooxygenase Inhibitors; Dinitrochlorobenzene; Drug Resistance; Estradiol; Glutathione; Humans; Indomethacin; Methotrexate; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxygen; Phosphorylation; Thioguanine; Time Factors; Transfection; Verapamil | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk).
Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water | 2005 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.
Topics: 4-Aminobenzoic Acid; Animals; Cell Line; Cell Line, Tumor; Dogs; Drug Resistance, Multiple; Humans; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; para-Aminobenzoates; Thiazines | 2008 |
First-principle, structure-based prediction of hepatic metabolic clearance values in human.
Topics: Computational Biology; Drug Discovery; Hepatocytes; Humans; Hydrogen-Ion Concentration; Liver; Metabolic Clearance Rate; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship; Sensitivity and Specificity; Software | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.
Topics: Antineoplastic Agents; Blood Proteins; Caco-2 Cells; Cell Membrane Permeability; Computer Simulation; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Phosphoproteins; Protein Binding; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Quantitative Structure-Activity Relationship | 2009 |
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley | 2009 |
Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay.
Topics: 1-Methyl-3-isobutylxanthine; Cell Line; Cell Membrane Permeability; Humans; Models, Biological; Quantitative Structure-Activity Relationship; Skin Absorption | 2010 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability?
Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis | 2010 |
Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells.
Topics: Abietanes; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Doxorubicin; Drug Resistance, Neoplasm; Humans; Models, Biological; Molecular Structure; Phenanthrenes; Plants, Medicinal; Salvia miltiorrhiza | 2010 |
Novel structure-activity relationships and selectivity profiling of cage dimeric 1,4-dihydropyridines as multidrug resistance (MDR) modulators.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Cell Line, Tumor; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Mice; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Structure-Activity Relationship | 2010 |
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans.
Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Flavonoids; Humans; Hydrogen Bonding; Models, Molecular; Neoplasm Proteins; Quantitative Structure-Activity Relationship | 2011 |
QSAR-based permeability model for drug-like compounds.
Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship | 2011 |
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites.
Topics: Glutathione; Pharmacology; Sulfur Radioisotopes | 2011 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration | 2011 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.
Topics: Anti-Inflammatory Agents, Non-Steroidal; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Chemistry Techniques, Synthetic; Cyclooxygenase Inhibitors; Drug Design; Drug Resistance, Multiple; Humans; Indomethacin; Models, Molecular; Molecular Conformation; Prostaglandin-Endoperoxide Synthases | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
A high-throughput cell-based method to predict the unbound drug fraction in the brain.
Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
Straightforward entry to pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones and their ADME properties.
Topics: Caco-2 Cells; Carboxylic Acids; Cell Membrane Permeability; Esterification; Half-Life; Humans; Microsomes, Liver; Pyrimidinones; Solubility | 2014 |
Development of an
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Blood-Brain Barrier; Cell Line; Computer Simulation; Endothelial Cells; Gene Knockout Techniques; Humans; Organic Chemicals; Rats, Transgenic | 2021 |
[Prevention of premature labor].
Topics: Adrenergic beta-Agonists; Aspirin; Female; Humans; Indomethacin; Obstetric Labor, Premature; Pregnancy; Rheumatic Diseases; Verapamil | 1975 |
Increased phosphorylation of specific blood platelet proteins in association with the release reaction.
Topics: Blood Platelets; Blood Proteins; Bucladesine; Calcimycin; Collagen; Cytochalasin B; Electrophoresis, Polyacrylamide Gel; Ethylmaleimide; Humans; Indomethacin; Molecular Weight; Phosphoproteins; Prostaglandins E; Verapamil | 1976 |
Relationship between phosphorylation of blood platelet proteins and secretion of platelet granule constituents II. Effects of different inhibitors.
Topics: Blood Platelets; Blood Proteins; Bucladesine; Collagen; Cytochalasin B; Ethylmaleimide; Humans; In Vitro Techniques; Indomethacin; Prostaglandins E; Tetracaine; Verapamil | 1978 |
The treatment of threatened premature labor by tocolytics, Ca++-Antagonists and anti-inflammatory drugs.
Topics: Adrenergic beta-Agonists; Animals; Anti-Inflammatory Agents; Aspirin; Calcium; Drug Therapy, Combination; Female; Humans; Indomethacin; Isoproterenol; Muscle Contraction; Obstetric Labor, Premature; Oxytocin; Papaverine; Parasympatholytics; Pregnancy; Prostaglandin Antagonists; Rats; Uterus; Verapamil | 1975 |
Effects of the calcium antagonist verapamil on in vitro synthesis of skeletal collagen and noncollagen protein.
Topics: Animals; Bone and Bones; Calcium; Collagen; DNA; Fetus; Indomethacin; Proline; Protein Biosynthesis; Rats; Verapamil | 1979 |
Electrical activity of human colonic smooth muscle in vitro.
Topics: Acetylcholine; Action Potentials; Colon; Humans; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Physostigmine; Tetrodotoxin; Verapamil | 1978 |
Interactions of T-kinin (Ile-Ser-bradykinin) with neurogenic, autacoidal and effector systems in affecting cardiovascular function.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Bucladesine; Diastole; Heart Rate; Hexamethonium; Hexamethonium Compounds; Histamine; Hydrocortisone; Indomethacin; Isoproterenol; Papaverine; Rats; Systole; Tyramine; Vagotomy; Verapamil | 1992 |
Slow channel calcium blockers attenuate reoxygenation-mediated vascular contraction, but augment anoxia-mediated vascular contraction.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Aorta; Diltiazem; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxygen; Oxyhemoglobins; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Inbred Strains; Thromboxane A2; Vasoconstriction; Verapamil | 1992 |
Ipsilateral cluster headache and chronic paroxysmal hemicrania: two case reports.
Topics: Adult; Chronic Disease; Cluster Headache; Drug Therapy, Combination; Humans; Indomethacin; Male; Middle Aged; Migraine Disorders; Verapamil | 1992 |
Chemotaxis of human blood monocytes toward endothelin-1 and the influence of calcium channel blockers.
Topics: Aspirin; Calcium Channel Blockers; Chemotaxis, Leukocyte; Diltiazem; Dose-Response Relationship, Drug; Endothelins; Humans; In Vitro Techniques; Indomethacin; Kinetics; Monocytes; Neomycin; Nifedipine; Probucol; Thioctic Acid; Verapamil | 1992 |
Triggering by ATP of product release by mucous granules of the land slug Ariolimax columbianus.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcimycin; Cytoplasmic Granules; Dinoprostone; Electric Stimulation; Ethylmaleimide; Furosemide; Ibuprofen; Indomethacin; Kinetics; Microscopy, Electron; Mollusca; Mucous Membrane; Nigericin; Pertussis Toxin; Tetradecanoylphorbol Acetate; Verapamil; Virulence Factors, Bordetella | 1992 |
Monochloramine induces contraction of guinea pig gallbladder via two different pathways.
Topics: Aminosalicylic Acids; Animals; Chloramines; Gallbladder; Guinea Pigs; Hydrogen Peroxide; Hypochlorous Acid; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Mesalamine; Models, Biological; Muscle, Smooth; Piroxicam; Tetrodotoxin; Verapamil; Virulence Factors, Bordetella | 1991 |
Effects of palytoxin on guinea pig tracheal strips.
Topics: Acrylamides; Airway Resistance; Animals; Atropine; Calcium; Cnidarian Venoms; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Masoprocol; Muscle Contraction; Muscle, Smooth; Ouabain; Potassium; Pyrilamine; Sodium; Solutions; Trachea; Verapamil | 1991 |
Tributyltin stimulates reactive oxygen formation in toadfish macrophages.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Benzoates; Benzoic Acid; Calcimycin; Calcium; Calcium Channels; Fishes; Free Radical Scavengers; Free Radicals; Indomethacin; Luminescent Measurements; Macrophage Activation; Macrophages; Masoprocol; Oxygen; Superoxide Dismutase; Tetradecanoylphorbol Acetate; Trialkyltin Compounds; Trifluoperazine; Verapamil | 1991 |
Effects of calcitriol on stimulation of ion transport in pig jejunal mucosa.
Topics: Animals; Calbindins; Calcimycin; Calcitriol; Calcium; Calcium Channel Blockers; Chlorides; Gallic Acid; In Vitro Techniques; Indomethacin; Intestinal Mucosa; Ion Transport; Jejunum; Rickets; S100 Calcium Binding Protein G; Sodium; Swine; Theophylline; Verapamil | 1991 |
Respiratory epithelium-dependent inhibition of protein kinase C of airway smooth muscle cells.
Topics: Animals; Dinoprostone; Epithelium; Guinea Pigs; Indomethacin; Isometric Contraction; Membrane Potentials; Muscle, Smooth; Protein Kinase C; Tetradecanoylphorbol Acetate; Trachea; Verapamil | 1991 |
Effects of antiplatelet agents alone or in combinations on platelet aggregation and on liver metastases from a human pancreatic adenocarcinoma in the nude mouse.
Topics: Adenocarcinoma; Animals; Colforsin; Drug Interactions; Humans; Indomethacin; Ketoconazole; Liver Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Platelet Aggregation; Platelet Aggregation Inhibitors; Tumor Cells, Cultured; Verapamil | 1991 |
Inhibition of thromboxane synthetase potentiates the antihypertensive action of an angiotensin-converting enzyme inhibitor by a prostaglandin-dependent but kinin-independent mechanism.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Benzazepines; Blood Pressure; Drug Synergism; Indomethacin; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Renin; Species Specificity; Thromboxane-A Synthase; Verapamil | 1991 |
Studies on the mechanism of Salmonella typhimurium enterotoxin-induced diarrhoea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Calcimycin; Calcium; Chlorides; Diarrhea; Enterotoxins; Indomethacin; Intestinal Mucosa; Intestine, Small; Isoquinolines; Male; Piperazines; Prostaglandins; Protein Kinase C; Rats; Rats, Inbred Strains; Salmonella typhimurium; Sodium; Tetradecanoylphorbol Acetate; Verapamil; Water-Electrolyte Balance | 1991 |
Arachidonic acid-induced secretion in the rat colon. Indomethacin-resistant neuronal and epithelial actions.
Topics: Animals; Antihypertensive Agents; Arachidonic Acid; Arachidonic Acids; Atropine; Chlorides; Colon; Female; Hexamethonium; Hexamethonium Compounds; Indomethacin; Masoprocol; Rats; Rats, Inbred Strains; Submucous Plexus; Tetrodotoxin; Verapamil | 1990 |
Protective effect of tauroursodeoxycholate against chenodeoxycholate-induced damage to cultured rabbit gastric cells.
Topics: Animals; Bile Acids and Salts; Calcium; Cells, Cultured; Chenodeoxycholic Acid; Dinoprostone; Dose-Response Relationship, Drug; Female; Free Radicals; Gastric Mucosa; Indomethacin; Isomerism; Male; Rabbits; Taurochenodeoxycholic Acid; Verapamil | 1991 |
Effect of treatment with enalapril, verapamil and indomethacin on compensatory renal growth in the rat.
Topics: Animals; Body Weight; Enalapril; Hypertrophy; Indomethacin; Kidney; Male; Nephrectomy; Organ Size; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Protein kinase C and intestinal fluid secretion: involvement of prostaglandin E2 but not of 5-hydroxytryptamine.
Topics: Animals; Body Fluids; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Female; Indomethacin; Intestinal Mucosa; Jejunum; Ketanserin; Protein Kinase C; Rats; Rats, Inbred Strains; Serotonin; Tetradecanoylphorbol Acetate; Verapamil | 1990 |
Effect of polycations on the function of the isolated perfused rat kidney.
Topics: Animals; Heparin; Indomethacin; Kidney; Male; Nephrosis, Lipoid; Organ Culture Techniques; Perfusion; Polylysine; Protamines; Rats; Rats, Inbred Strains; Verapamil | 1990 |
Efflux of bis-carboxyethyl-carboxyfluorescein (BCECF) by a novel ATP-dependent transport mechanism in epithelial cells.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Cell Line; Epithelium; Fluoresceins; Fluorescent Dyes; Humans; Indomethacin; Kinetics; Nifedipine; Reserpine; Verapamil; Vinblastine | 1990 |
The effect of neomycin on contractile activity of the canine cervical lymphatic vessel induced by various agents.
Topics: Animals; Dogs; Female; In Vitro Techniques; Indomethacin; Isometric Contraction; Lymphatic System; Male; Muscle Contraction; Muscle, Smooth; Neomycin; Norepinephrine; Phenylephrine; Potassium Chloride; Sodium Fluoride; Verapamil | 1990 |
Pharmacologic effects on coronary microvessels during myocardial ischaemia.
Topics: Animals; Blood Flow Velocity; Capillary Permeability; Coronary Circulation; Coronary Disease; Coronary Vessels; Erythrocyte Count; Fatty Acids; Gallopamil; Imidazoles; Indomethacin; Microcirculation; Platelet Count; Rats; Thromboxane-A Synthase; Verapamil | 1990 |
Comparison of the effects of bacterial lipopolysaccharide and muramyl dipeptide on food intake.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Appetite; Drinking; Eating; Energy Metabolism; Gastric Emptying; Indomethacin; Lipopolysaccharides; Male; Rats; Rats, Inbred Strains; Satiety Response; Taste; Verapamil | 1990 |
[The effects of indomethacin and verapamil on dextran-induced shock in rats].
Topics: Animals; Dextrans; Indomethacin; Male; Rats; Rats, Inbred Strains; Shock, Septic; Verapamil | 1985 |
Thrombin-induced calcium movements in platelet activation.
Topics: Aminoquinolines; Bepridil; Biological Transport; Blood Platelets; Calcimycin; Calcium; Chlortetracycline; Fluorescence; Humans; Indomethacin; Ion Channels; Platelet Aggregation; Pyrrolidines; Thrombin; Verapamil | 1987 |
Elevation of angiotensin converting enzyme by 3-isobutyl-1-methylxanthine in cultured endothelial cells: a possible role for calmodulin.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calmodulin; Cattle; Cells, Cultured; Cyclic AMP; Cycloheximide; Dose-Response Relationship, Drug; Egtazic Acid; Endothelium, Vascular; Imidazoles; Indomethacin; Peptidyl-Dipeptidase A; Propranolol; Theophylline; Trifluoperazine; Verapamil; Xanthines | 1988 |
Calcitonin gene-related peptides relax guinea pig and rat gastric smooth muscle.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Calcitonin Gene-Related Peptide; Female; Guinea Pigs; Humans; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth; Neuropeptides; Rats; Rats, Inbred Strains; Stomach; Verapamil | 1989 |
Impaired canine coronary vasodilator response to acetylcholine and bradykinin after occlusion-reperfusion.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Animals; Bradykinin; Coronary Circulation; Coronary Vessels; Dogs; Female; Hemodynamics; Indomethacin; Male; Myocardial Reperfusion; Myocardium; Peroxidase; Vasodilation; Verapamil | 1989 |
Involvement of 5-hydroxytryptamine, prostaglandin E2, and cyclic adenosine monophosphate in cholera toxin-induced fluid secretion in the small intestine of the rat in vivo.
Topics: Animals; Body Fluids; Cholera Toxin; Cyclic AMP; Dinoprostone; Dose-Response Relationship, Drug; Female; Indomethacin; Intestine, Small; Ketanserin; Nifedipine; Rats; Rats, Inbred Strains; Serotonin; Time Factors; Verapamil | 1989 |
Pharmacological characterization of mare uterus motility with special reference to calcium antagonists and beta-2-adrenergic stimulants.
Topics: Adrenergic beta-Agonists; Albuterol; Animals; Calcium Channel Blockers; Culture Media; Cyclic AMP; Diltiazem; Female; Hexoprenaline; Horses; In Vitro Techniques; Indomethacin; Myometrium; Nifedipine; Tetrodotoxin; Uterine Contraction; Verapamil | 1989 |
Effects of verapamil on the contractions of guinea-pig tracheal muscle induced by Ca, Sr and Ba.
Topics: Animals; Barium; Calcium; Carbachol; Dinoprost; Guinea Pigs; In Vitro Techniques; Indomethacin; Ion Channels; Muscle Contraction; Muscle, Smooth; Prostaglandins F; Strontium; Trachea; Verapamil | 1985 |
Some properties of calcium-induced contraction in the isolated human and guinea-pig tracheal smooth muscle.
Topics: Aged; Animals; Aspirin; Calcium; Chromones; Female; Guinea Pigs; Humans; Indomethacin; Ion Channels; Male; Middle Aged; Muscle Contraction; Muscle Tonus; Muscle, Smooth; SRS-A; Trachea; Verapamil | 1985 |
Pharmacological modulation of the bronchopulmonary action of the vasoactive peptide, endothelin, administered by aerosol in the guinea-pig.
Topics: Aerosols; Animals; Blood Pressure; Bronchi; Diterpenes; Endothelins; Endothelium, Vascular; Ginkgolides; Guinea Pigs; Indomethacin; Lactones; Male; Nifedipine; Peptides; Plant Extracts; Platelet Activating Factor; Propranolol; Pyrilamine; Verapamil | 1989 |
Verapamil and indomethacin attenuate endotoxin-induced anorexia.
Topics: Animals; Anorexia; Dose-Response Relationship, Drug; Drug Interactions; Escherichia coli Infections; Feeding and Eating Disorders; Feeding Behavior; Indomethacin; Lipopolysaccharides; Male; Phentolamine; Propranolol; Rats; Rats, Inbred Strains; Verapamil | 1989 |
Effects of hypoxia on the pharmacological responsiveness of isolated coronary artery rings from the sheep.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Coronary Vessels; Hypoxia; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Oxygen Consumption; Phentolamine; Potassium Chloride; Propranolol; Prostaglandin Endoperoxides, Synthetic; Serotonin; Sheep; Verapamil | 1989 |
A modulating role of prostaglandins in catecholamine release by perfused dog adrenal glands.
Topics: Acetylcholine; Adrenal Glands; Animals; Calcium; Calcium Radioisotopes; Catecholamines; Cyclic AMP; Dinoprostone; Dogs; Female; In Vitro Techniques; Indomethacin; Male; Perfusion; Prostaglandins; Prostaglandins E; Verapamil | 1988 |
Release of prostaglandins during the contraction of rat aorta induced by ouabain and K+-free solution.
Topics: Animals; Aorta, Thoracic; Calcium; In Vitro Techniques; Indomethacin; Ion Exchange; Male; Muscle Contraction; Muscle, Smooth, Vascular; Ouabain; Potassium; Prostaglandins; Rats; Sodium; Sodium-Potassium-Exchanging ATPase; Verapamil | 1988 |
Platelet aggregation caused by Carybdea rastonii toxins (CrTX-I, II and III) obtained from a jellyfish, Carybdea rastonii.
Topics: Animals; Blood Platelets; Calcium; Cell Membrane; Chromatography, Gel; Cnidarian Venoms; Dose-Response Relationship, Drug; Indomethacin; Membrane Potentials; Platelet Aggregation; Quinacrine; Rabbits; Scyphozoa; Sodium; Verapamil | 1986 |
Stimulant action of pethidine on the pregnant rat uterus in-vitro.
Topics: Animals; Drug Interactions; Female; In Vitro Techniques; Indomethacin; Meperidine; Methysergide; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Stimulation, Chemical; Uterine Contraction; Verapamil | 1987 |
Palytoxin-induced contraction and release of prostaglandins and norepinephrine in the aorta.
Topics: Acrylamides; Animals; Aorta; Biological Products; Cnidarian Venoms; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Nitric Oxide; Norepinephrine; Prostaglandins; Rabbits; Rats; Rats, Inbred Strains; Vasoconstriction; Verapamil | 1987 |
Antiulcerogenic and antisecretory effects of a novel diphenylmethane derivative and antiestrogen binding site ligand.
Topics: Animals; Bethanechol; Bethanechol Compounds; Corticosterone; Gastric Acid; Indomethacin; Male; Phenyl Ethers; Rats; Rats, Inbred Strains; Receptors, Drug; Receptors, Estrogen; Ulcer; Verapamil | 1988 |
Potassium-mediated stimulation of hepatic glycogenolysis.
Topics: Animals; Atrial Natriuretic Factor; Atropine; Egtazic Acid; In Vitro Techniques; Indomethacin; Kinetics; Liver; Liver Glycogen; Masoprocol; Nifedipine; Nitroprusside; Perfusion; Phentolamine; Potassium; Propranolol; Rats; Verapamil | 1987 |
Comparison of the ulcerogenicity of indomethacin and the gastric secretion in verapamil-treated rats.
Topics: Animals; Dose-Response Relationship, Drug; Gastric Juice; Gastric Mucosa; Hydrochloric Acid; Hydrogen-Ion Concentration; Indomethacin; Male; Rats; Rats, Inbred Strains; Stomach Ulcer; Verapamil | 1988 |
T lymphocyte responses to Coxsackie B4 and mumps virus. I. Influence of HLA-DR restriction elements.
Topics: Aminophylline; Antigens, Viral; Diabetes Mellitus, Type 1; Enterovirus; Herpesvirus 3, Human; Histocompatibility Antigens Class II; HLA-DR Antigens; HLA-DR3 Antigen; HLA-DR4 Antigen; Humans; In Vitro Techniques; Indomethacin; Lymphocyte Activation; Mumps virus; T-Lymphocytes; Verapamil | 1985 |
Significance of calcium for the prostaglandin E2-mediated secretory response to 5-hydroxytryptamine in the small intestine of the rat in vivo.
Topics: Animals; Calcium; Creatinine; Cyclic AMP; Dinoprostone; Drug Combinations; Female; Indomethacin; Intestinal Secretions; Intestine, Small; Prostaglandins E; Rats; Rats, Inbred Strains; Serotonin; Vasoactive Intestinal Peptide; Verapamil | 1986 |
Vascular responses to leukotriene B4, C4 and D4 following FPL 55712, indomethacin, saralasin, phentolamine and verapamil in the conscious rat.
Topics: Animals; Blood Pressure; Chromones; Female; Heart Rate; Hematocrit; Indomethacin; Leukotriene B4; Phentolamine; Prostaglandins E; Rats; Rats, Inbred Strains; Saralasin; SRS-A; Verapamil | 1987 |
Pharmacological modification of pulmonary vascular injury: possible role of cAMP.
Topics: Alprostadil; Animals; Cell Membrane Permeability; Cyclic AMP; Hypertension, Pulmonary; Indomethacin; Isoproterenol; Male; Peroxides; Rabbits; tert-Butylhydroperoxide; Verapamil | 1987 |
Platelet-activating factor-induced ischemic bowel necrosis. An investigation of secondary mediators in its pathogenesis.
Topics: Alprostadil; Animals; Blood Pressure; Catechols; Chromones; Diethylcarbamazine; Disease Models, Animal; Hematocrit; Indomethacin; Intestines; Ischemia; Leukocyte Count; Lipopolysaccharides; Lipoxygenase Inhibitors; Male; Masoprocol; Methacrylates; Necrosis; Platelet Activating Factor; Rats; Rats, Inbred Strains; Salmonella typhi; Thromboxane-A Synthase; Verapamil | 1986 |
Effects of phorbol esters on sodium and chloride transport in rat colon.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport; Calcium; Chlorides; Colon; Ibuprofen; Indomethacin; Intestinal Absorption; Phorbol 12,13-Dibutyrate; Phorbol Esters; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Rats; Rats, Inbred Strains; Sodium; Tetrodotoxin; Verapamil | 1986 |
Prostaglandin involvement in the evoked release of D-aspartate from cerebellar mossy fiber terminals.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Aspartic Acid; Biological Transport; Cerebellum; Dinoprost; Dinoprostone; Ibuprofen; Indomethacin; Kinetics; Potassium; Prostaglandins; Prostaglandins E; Prostaglandins F; Rats; Stereoisomerism; Tetrodotoxin; Verapamil | 1986 |
Calcium entry blocker: treatment in acute pain in cluster headache patients.
Topics: Blood Pressure; Cluster Headache; Humans; Indomethacin; Lithium; Nitroglycerin; Pain Measurement; Pulse; Vascular Headaches; Verapamil | 1986 |
Cyclooxygenase--independent pathway of phospholipase activation in carrageenan--induced platelet aggregation.
Topics: Animals; Calcium; Carrageenan; Chlorpromazine; Drug Synergism; Enzyme Activation; Indomethacin; Nitroprusside; Phospholipases; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Rabbits; Tetracaine; Verapamil | 1987 |
Changes of vascular endothelial cell shape and of membrane potential in response to the ionophore A23187.
Topics: Animals; Calcimycin; Calcium; Endothelium; Guinea Pigs; In Vitro Techniques; Indomethacin; Membrane Potentials; Microscopy, Electron; Microscopy, Electron, Scanning; Thorax; Vena Cava, Inferior; Verapamil | 1987 |
Effects of cyclosporin on renal microcirculation.
Topics: Animals; Captopril; Cyclosporins; Glomerular Filtration Rate; Indomethacin; Kidney Glomerulus; Microcirculation; Rats; Rats, Inbred Strains; Renal Circulation; Renin-Angiotensin System; Verapamil | 1987 |
Effect of pharmacological agents on the activity of the circular and longitudinal smooth muscle layers of human fallopian tube ampullar segments.
Topics: Adult; Dinoprost; Fallopian Tubes; Female; Humans; In Vitro Techniques; Indomethacin; Isoproterenol; Middle Aged; Muscle Contraction; Muscle, Smooth; Norepinephrine; Oxytocin; Prostaglandins F; Verapamil | 1988 |
The effects of indomethacin and verapamil on the shape changes of vascular endothelial cells resulting from exposure to various inflammatory agents.
Topics: Animals; Bradykinin; Dinoprostone; Endothelium, Vascular; Guinea Pigs; Histamine Antagonists; In Vitro Techniques; Indomethacin; Leukotriene Antagonists; Microscopy, Electron; Verapamil | 1988 |
Studies on thrombin-induced endothelium-dependent vascular effects.
Topics: Animals; Bradykinin; Coronary Circulation; Dinoprost; Endothelium, Vascular; Hirudins; Humans; In Vitro Techniques; Indomethacin; Platelet Aggregation; Swine; Thrombin; Verapamil | 1988 |
Effect of calcium channel blocker diltiazem on cytoprotection and prostaglandin and sulfhydryl production by rat gastric epithelial cells.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cells, Cultured; Diltiazem; Dinoprostone; Epithelium; Ethanol; Gastric Mucosa; Indomethacin; Prostaglandins; Rats; Rats, Inbred Strains; Sulfhydryl Compounds; Taurocholic Acid; Verapamil | 1988 |
The spasmogenic effect of caffeine in trachealis isolated from control and actively sensitized guinea-pigs.
Topics: Animals; Caffeine; Calcium; Dantrolene; Guinea Pigs; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Temperature; Trachea; Trifluoperazine; Verapamil | 1988 |
Glomerular hemodynamics and hormonal participation on cyclosporine nephrotoxicity.
Topics: Animals; Captopril; Cyclosporins; Glomerular Filtration Rate; Hemodynamics; Hormones; Indomethacin; Kidney Glomerulus; Male; Rats; Rats, Brattleboro; Rats, Inbred Strains; Verapamil | 1987 |
Role of the loop segment in the urinary concentrating defect of hypercalcemia.
Topics: Animals; Biological Transport, Active; Calcium; Calcium Gluconate; Chlorides; Ergocalciferols; Hypercalcemia; Indomethacin; Kidney Concentrating Ability; Kidney Tubules; Loop of Henle; Male; Rats; Rats, Inbred Strains; Verapamil | 1986 |
Comparative effects of Mg, Ca, Sr, and verapamil on the uterine longitudinal muscle of spayed and estrogen-treated rats.
Topics: Action Potentials; Animals; Calcium; Electric Stimulation; Estrogens; Female; Indomethacin; Magnesium; Ovariectomy; Rats; Rats, Inbred Strains; Sodium; Strontium; Uterine Contraction; Verapamil | 1986 |
Effects of indomethacin or verapamil on dialysis induced leucopenia and hypoxia in the unstressed sheep.
Topics: Animals; Extracorporeal Circulation; Hypoxia; Indomethacin; Leukopenia; Renal Dialysis; Sheep; Verapamil | 1987 |
Pre- and postsynaptic bradykinin responses in the rat vas deferens: asymmetric distribution of the postsynaptic effect.
Topics: Animals; Bradykinin; Drug Interactions; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Neurons; Nifedipine; Rats; Rats, Inbred Strains; Synapses; Tetrodotoxin; Vas Deferens; Verapamil | 1986 |
Electrical changes produced by injury to the rat myocardium in vitro and the protective effects of certain antiarrhythmic drugs.
Topics: Animals; Anti-Arrhythmia Agents; Calcium; Coronary Disease; Electric Stimulation; Heart Conduction System; In Vitro Techniques; Indomethacin; Oxygen; Rats; Rats, Inbred Strains; Sulfinpyrazone; Verapamil | 1987 |
Inhibitory effect of quinacrine on myocardial reactive hyperemia in the dog.
Topics: Acetylcholine; Adenosine; Animals; Blood Flow Velocity; Catechols; Coronary Circulation; Dogs; Female; Heart Rate; Hyperemia; Indomethacin; Male; Masoprocol; Pyrazoles; Quinacrine; Regional Blood Flow; Theophylline; Verapamil | 1985 |
Response to platelet-activating factor of platelets from patients with multiple sclerosis.
Topics: Acetophenones; Blood Platelets; Calcium; Humans; Indomethacin; Multiple Sclerosis; Platelet Activating Factor; Platelet Aggregation; Verapamil | 1985 |
Angiotensin II enhances calcium exchanges in isolated rat aorta.
Topics: Angiotensin II; Animals; Aorta; Biological Transport; Calcium; Indomethacin; Male; Rats; Rats, Inbred Strains; Saralasin; Verapamil | 1985 |
Pharmacological investigation of the mechanisms of platelet-activating factor induced mortality in the mouse.
Topics: Anaphylaxis; Animals; Chloroquine; Chlortetracycline; Dexamethasone; Dose-Response Relationship, Drug; Female; Indomethacin; Injections, Intravenous; Male; Mice; Mice, Inbred DBA; Naproxen; Nicardipine; Nifedipine; Platelet Activating Factor; Pyrazoles; Quinacrine; Tetracycline; Verapamil | 1985 |
[Spontaneous contraction of the human saphenous vein and electric stimulation].
Topics: Electric Stimulation; Humans; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth, Vascular; Phentolamine; Prostaglandins; Saphenous Vein; Verapamil | 1985 |
Further studies on the mechanism of phosphorylase activation in rabbit liver in response to splanchnic nerve stimulation.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Calcium Channel Blockers; Diltiazem; Electric Stimulation; Enzyme Activation; Indomethacin; Liver; Male; Norepinephrine; Phosphorylase a; Phosphorylases; Rabbits; Splanchnic Nerves; Verapamil | 1982 |
Effect of phorbol esters on the release of growth hormone and prolactin from rat pituitary cells cultured in monolayer.
Topics: Animals; Calcium; Cells, Cultured; Growth Hormone; Hyaluronoglucosaminidase; Indomethacin; Male; Phorbol Esters; Phorbols; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Somatostatin; Trifluoperazine; Verapamil | 1984 |
Studies on the mechanism of action of glucagon in strips of rabbit renal artery.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium; Cyclic AMP; Female; Glucagon; In Vitro Techniques; Indomethacin; Male; Papaverine; Phosphodiesterase Inhibitors; Proadifen; Rabbits; Renal Artery; Theophylline; Vasodilator Agents; Verapamil | 1980 |
[Aldosterone production in vitro by angiotensin II: the role of Ca++].
Topics: Adrenal Glands; Aldosterone; Angiotensin II; Animals; Calcium; Cattle; Cyclic AMP; In Vitro Techniques; Indomethacin; Perfusion; Prostaglandins; Verapamil | 1980 |
Cyclic AMP and the regulation of prostaglandin production by macrophages.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Aspirin; Bucladesine; Calcimycin; Cholera Toxin; Cyclic AMP; Indomethacin; Kinetics; Macrophages; Prostaglandins; Rats; Verapamil | 1983 |
Reactive oxygen production, arachidonate metabolism and cyclic AMP in macrophages.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Bucladesine; Calcimycin; Cyclic AMP; Dinoprostone; Indomethacin; Kinetics; Luminescent Measurements; Macrophages; Oxygen; Prostaglandins E; Rats; Verapamil | 1983 |
A potent platelet aggregation inducer from Trimeresurus gramineus snake venom.
Topics: Adenine Nucleotides; Adenosine; Animals; Calcium; Cyclic AMP; Indomethacin; Malondialdehyde; Nitroprusside; Phospholipases A; Phospholipases A2; Platelet Aggregation; Prostaglandins E; Proteoglycans; Rabbits; Verapamil; Viper Venoms | 1983 |
The role of prostaglandins in the endothelium-mediated vasodilatory response to hypoxia.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Calcium; Dinoprostone; Dogs; Endothelium; Epoprostenol; Female; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth, Vascular; Oxygen; Prostaglandins; Prostaglandins E; Rats; Rats, Inbred Strains; Vasodilation; Verapamil | 1984 |
Possible mechanisms involved in the spontaneous rhythmicity in the guinea-pig tracheal smooth muscle as induced by glucose removal.
Topics: Animals; Atropine; Calcimycin; Female; Glucose; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Ouabain; Propranolol; Tetrodotoxin; Verapamil | 1983 |
Stimulation of calcium uptake by 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) in rabbit platelets: possible involvement of the lipoxygenase pathway.
Topics: Adenosine Diphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Biological Transport, Active; Blood Platelets; Calcium; Indomethacin; Platelet Activating Factor; Rabbits; Verapamil | 1983 |
Role of calcium in arachidonic acid-induced contractions of guinea pig airways.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Calcium Channel Blockers; Edetic Acid; Gallic Acid; Guinea Pigs; In Vitro Techniques; Indomethacin; Lanthanum; Lung; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Nitrendipine; SRS-A; Trachea; Verapamil | 1984 |
A pharmacologic analysis of the action of platelet-activating factor in the induction of hindpaw edema in the rat.
Topics: Animals; Carrageenan; Dexamethasone; Dose-Response Relationship, Drug; Edema; Hindlimb; Indomethacin; Male; Muscles; Phentolamine; Platelet Activating Factor; Rats; Rats, Inbred Strains; Regional Blood Flow; Theophylline; Verapamil; Yohimbine | 1984 |
Thromboxane formation during blood clotting is decreased by verapamil.
Topics: Blood Coagulation; Blood Platelets; Humans; Indomethacin; Methacrylates; Sulfinpyrazone; Thromboxane B2; Thromboxanes; Verapamil | 1984 |
Glucocorticoid protection against PAF-acether toxicity in mice.
Topics: Animals; Cortisone; Female; Glucocorticoids; Indomethacin; Male; Mice; Mice, Inbred Strains; Platelet Activating Factor; Sex Factors; Verapamil | 1983 |
Interaction of digoxin with verapamil, indomethacin, and other coadministered drugs: a comparative study in rat tissue.
Topics: Animals; Creatinine; Digoxin; Indomethacin; Male; Quinidine; Rats; Rats, Inbred Strains; Verapamil | 1983 |
The effect of prostaglandin E2 on histamine-stimulated calcium mobilization as a possible explanation for histamine tachyphylaxis in canine tracheal smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Dogs; Drug Interactions; Histamine; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Prostaglandins E; Tachyphylaxis; Trachea; Verapamil | 1983 |
Cellular calcium uptake in the action of prostaglandins on renal water excretion.
Topics: Animals; Biological Transport; Calcium; Cell Membrane Permeability; Diuresis; Dogs; Hemodynamics; Indomethacin; Kidney; Osmolar Concentration; Proadifen; Prostaglandins; Urodynamics; Vasopressins; Verapamil | 1981 |
Interaction between coronary active compounds and indomethacin on the cardiovascular system of dogs.
Topics: Blood Pressure; Dipyridamole; Heart; Heart Rate; Indomethacin; Verapamil | 1980 |
Exercise-induced coronary arterial spasm: angiographic demonstration, documentation of ischemia by myocardial scintigraphy and results of pharmacologic intervention.
Topics: Angina Pectoris, Variant; Coronary Disease; Exercise Test; Humans; Indomethacin; Male; Middle Aged; Myocardium; Nitrates; Phenoxybenzamine; Propranolol; Radiography; Radionuclide Imaging; Spasm; Verapamil | 1980 |
Effects of lead on osteoclast-like cell formation in mouse bone marrow cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bone Marrow; Bone Marrow Cells; Calcimycin; Calcitonin; Cell Differentiation; Cell Nucleus; Cells, Cultured; Cyclic AMP; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-acetylhydrazide; Dideoxyadenosine; Dinoprostone; Indomethacin; Lead; Male; Mice; Mice, Inbred Strains; Osteoclasts; Parathyroid Hormone; Verapamil | 1994 |
[Effect of endogenous metabolites on autoregulation and dilational reserve of coronary vessels].
Topics: Amino Acid Oxidoreductases; Angiotensin II; Animals; Arginine; Captopril; Coronary Circulation; Coronary Vessels; Eicosanoids; Female; In Vitro Techniques; Indomethacin; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Vasodilation; Verapamil | 1993 |
Effect of (+/-)-verapamil and hydralazine on stress- and chemically-induced gastric ulcers in rats.
Topics: Animals; Disease Models, Animal; Ethanol; Gastric Acid; Gastric Mucins; Hydralazine; Indomethacin; Male; Rats; Rats, Wistar; Reserpine; Stomach Ulcer; Stress, Physiological; Verapamil | 1994 |
Effect of ibudilast on ciliary activity of human paranasal sinus mucosa in vitro.
Topics: Bronchodilator Agents; Cilia; Humans; In Vitro Techniques; Indomethacin; Leukotriene D4; Mucociliary Clearance; Nasal Mucosa; Paranasal Sinuses; Platelet Activating Factor; Propranolol; Pyridines; Verapamil | 1995 |
Vasorelaxant effect of the analgesic clonixin on rat aorta.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Analgesics; Animals; Aorta, Thoracic; Blood Pressure; Calcium; Clonixin; Drug Interactions; Female; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Chloride; Rats; Rats, Sprague-Dawley; Verapamil | 1995 |
Purification and characterization of L-amino acid oxidase from king cobra (Ophiophagus hannah) venom and its effects on human platelet aggregation.
Topics: Alprostadil; Amino Acid Oxidoreductases; Animals; Antimycin A; Aspirin; Blood Coagulation Tests; Blood Platelets; Catalase; Chromatography, Gel; Chromatography, Ion Exchange; Drug Interactions; Edetic Acid; Elapid Venoms; Electrophoresis, Polyacrylamide Gel; Heparin; Hirudins; Humans; Hydrogen Peroxide; Indomethacin; Isoelectric Point; L-Amino Acid Oxidase; Molecular Weight; Nitroprusside; Platelet Aggregation; Quinacrine; Thromboxane A2; Verapamil | 1994 |
Effect of extracellular Ca2+ on indomethacin-induced injury to rabbit dispersed gastric mucosal cells.
Topics: 16,16-Dimethylprostaglandin E2; Acid Phosphatase; Animals; Arachidonic Acid; Biomarkers; Calcimycin; Calcium; Cell Membrane; Cytosol; Female; Gastric Mucosa; In Vitro Techniques; Indomethacin; Phospholipases A; Prostaglandins; Rabbits; Trypan Blue; Verapamil | 1994 |
Protection against necrotizing agents-induced gastric lesions in rats. Unrelated to inhibition of gastric motility.
Topics: Animals; Ethanol; Female; Gastrointestinal Motility; Hydrochloric Acid; Indomethacin; Male; Papaverine; Rats; Rats, Wistar; Sodium Chloride; Sodium Compounds; Sodium Hydroxide; Stomach Ulcer; Verapamil | 1994 |
Atrial natriuretic peptide inhibits the purinergic and not the adrenergic component of electrically induced contractile responses in guinea pig vas deferens.
Topics: Adenosine Triphosphate; Adrenergic Antagonists; Animals; Atrial Natriuretic Factor; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Naloxone; Neurotransmitter Agents; Nitrendipine; Phenylephrine; Prazosin; Receptors, Adrenergic; Receptors, Purinergic; Vas Deferens; Verapamil; Yohimbine | 1993 |
Cocaine-induced cerebrovasospasm and its possible mechanism of action.
Topics: Animals; Biological Transport; Brain; Calcium; Cells, Cultured; Cocaine; Cyclooxygenase Inhibitors; Dogs; Dopamine; Dopamine Antagonists; Eicosanoids; Female; Haloperidol; Indomethacin; Ischemic Attack, Transient; Male; Muscle Contraction; Sheep; Swine; Verapamil | 1994 |
[The autoregulation of the coronary flow of the isolated heart in rats after saponin damage to the endothelium].
Topics: Animals; Coronary Circulation; Drug Interactions; Endothelium, Vascular; Female; Homeostasis; In Vitro Techniques; Indomethacin; Muscle, Smooth, Vascular; Perfusion; Rats; Saponins; Vasodilation; Verapamil | 1993 |
Prostaglandins and sulfhydryls may mediate gastric protection induced by verapamil in rats.
Topics: Animals; Dose-Response Relationship, Drug; Ethanol; Female; Gastric Acid; Gastric Mucosa; Gastritis; Gastrointestinal Motility; Indomethacin; Iodoacetamide; Male; Prostaglandins; Rats; Rats, Wistar; Sulfhydryl Compounds; Verapamil | 1993 |
Positive end-expiratory pressure-induced, calcium-channel-mediated increases in pulmonary vascular resistance in neonatal lambs.
Topics: Airway Resistance; Animals; Animals, Newborn; Blood Pressure; Calcium Channels; Diethylcarbamazine; Indomethacin; Positive-Pressure Respiration; Prospective Studies; Pulmonary Artery; Pulmonary Circulation; Sheep; Vascular Resistance; Verapamil | 1993 |
Stimulation of prostaglandin synthesis by human endothelial cells exposed to hypoxia.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Arachidonic Acid; Calcium; Carbon Radioisotopes; Cell Hypoxia; Endothelium, Vascular; Humans; Indomethacin; Kinetics; Oxygen; Phospholipases A; Phospholipases A2; Prostaglandins; Quinacrine; Stearic Acids; Tritium; Umbilical Veins; Verapamil | 1993 |
Cyclosporine and oxidized lipoproteins affect vascular reactivity. Influence of the endothelium.
Topics: Acetylcholine; Animals; Cyclosporine; Endothelium, Vascular; Female; Humans; In Vitro Techniques; Indomethacin; Lipoproteins, LDL; Male; Norepinephrine; Oxidation-Reduction; Rabbits; Renal Artery; Saralasin; Vasoconstriction; Verapamil | 1993 |
Stimulation of mitogenesis in human thyroid epithelial cells by endothelin.
Topics: Calcium; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Endothelins; Epithelial Cells; Epithelium; Graves Disease; Heparin; Humans; Indomethacin; Interleukin-1; Recombinant Proteins; Thyroid Gland; Verapamil | 1993 |
Effects of phorbol 12,13-diacetate and its influence on spasmogenic responses in normal and sensitized guinea-pig trachea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Calcium; Diuretics; Guinea Pigs; Histamine; In Vitro Techniques; Indomethacin; Isoquinolines; Male; Muscle Contraction; Muscle, Smooth; Phorbol Esters; Piperazines; Potassium Chloride; Protein Kinase C; Serotonin; Trachea; Vasodilator Agents; Verapamil | 1995 |
Pharmacologic characterization of wool dust extract in isolated guinea pig trachea.
Topics: Air Pollutants, Occupational; Animals; Atropine; Bronchoconstriction; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Dust; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Indomethacin; Leukotriene Antagonists; Male; Occupational Exposure; Pyrilamine; Trachea; Verapamil; Wool | 1995 |
Porcine von Willebrand factor binding to human platelet GPIb induces transmembrane calcium influx.
Topics: Animals; Antibodies, Monoclonal; Calcium; Calcium Channel Blockers; Cell Membrane; Humans; Indomethacin; Peptide Fragments; Platelet Glycoprotein GPIb-IX Complex; Protein Binding; Protein Synthesis Inhibitors; Recombinant Proteins; Second Messenger Systems; Stress, Mechanical; Swine; Verapamil; von Willebrand Factor | 1996 |
Endothelin receptors and activity differ in human, dog, and rabbit lung.
Topics: Animals; Bronchi; Calcium; Calcium Channel Blockers; Dogs; Endothelin Receptor Antagonists; Endothelins; Extracellular Space; Humans; Indomethacin; Peptide Fragments; Peptides, Cyclic; Rabbits; Receptors, Endothelin; Staurosporine; Verapamil | 1996 |
Differential effects of maitotoxin on calcium entry and ciliary beating in the rabbit ciliated tracheal epithelium.
Topics: Animals; Arachidonic Acids; Biological Transport, Active; Bradykinin; Calcium; Calcium Channel Blockers; Chelating Agents; Cilia; Cyclic AMP; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Inhibitors; Epithelium; Indomethacin; Inositol Phosphates; Ionomycin; Kinetics; Lipoxygenase Inhibitors; Marine Toxins; Masoprocol; Motion; Oxocins; Phospholipases A; Quinacrine; Rabbits; Signal Transduction; Stimulation, Chemical; Terpenes; Thapsigargin; Trachea; Trifluoperazine; Verapamil | 1995 |
Effects of a prostaglandin I2 analog iloprost on cytoplasmic Ca2+ levels and muscle contraction in isolated guinea pig aorta.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Aorta; Calcium; Cyclic AMP; Dinoprost; Dose-Response Relationship, Drug; Guinea Pigs; Iloprost; In Vitro Techniques; Indomethacin; Male; Muscle, Smooth, Vascular; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Vasoconstriction; Verapamil | 1996 |
Endotoxin stimulates in vitro pituitary growth hormone release in eicosanoid-dependent manner.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Arachidonic Acids; Calcium Channel Blockers; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Eicosanoids; Endotoxins; Growth Hormone; In Vitro Techniques; Indomethacin; Lipoxygenase Inhibitors; Male; Masoprocol; Protein Kinase C; Sheep; Signal Transduction; Tetradecanoylphorbol Acetate; Verapamil | 1996 |
Direct vasodilatory effect of insulin on isolated retinal arterioles.
Topics: Animals; Arterioles; Calcium Channel Blockers; Calcium Channels; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypoglycemic Agents; Indomethacin; Insulin; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Retinal Artery; Swine; Vasodilation; Verapamil | 1996 |
PACAPs stimulate duodenal bicarbonate secretion at PACAP receptors in the rat.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Atropine; Bicarbonates; Cyclic AMP; Dinoprostone; Duodenum; Gastric Mucosa; Indomethacin; Male; Neuropeptides; Pituitary Adenylate Cyclase-Activating Polypeptide; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; Receptors, Pituitary Hormone; Secretory Rate; Vagotomy; Vagus Nerve; Vasoactive Intestinal Peptide; Verapamil | 1997 |
Calcium and protein kinase C play a significant role in response to Shigella toxin in rabbit ileum both in vivo and in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bacterial Toxins; Calcimycin; Calcium; Cyclic AMP; Cyclic GMP; Electrolytes; Ileum; Indomethacin; Inositol Phosphates; Male; Neutralization Tests; Prostaglandins E; Protein Kinase C; Rabbits; Shiga Toxins; Tetradecanoylphorbol Acetate; Verapamil | 1997 |
Inhibitor analysis of LDL-induced platelet aggregation.
Topics: Acetophenones; Adenosine Diphosphate; Calcium; Enzyme Inhibitors; Humans; Indomethacin; Lipoproteins, LDL; Masoprocol; Neomycin; Phosphatidylinositols; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Kinase C; Receptors, LDL; Signal Transduction; Thiobarbituric Acid Reactive Substances; Type C Phospholipases; Verapamil | 1997 |
Dopamine potentiation of calcium ionophore, A-23187-induced platelet aggregation.
Topics: 3,4-Dihydroxyphenylacetic Acid; Alkaloids; Androstadienes; Aspirin; Benzophenanthridines; Calcimycin; Calcium; Chlorpromazine; Diltiazem; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; GTP-Binding Proteins; Haloperidol; Homovanillic Acid; Humans; Indomethacin; Ion Transport; Ionophores; Phenanthridines; Phentolamine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Propranolol; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Dopamine; Serotonin; Signal Transduction; Verapamil; Wortmannin | 1997 |
[Effect of platelet activating factor on TxA2, PGI2 and Ca(2+)-ATPase activity in the intra-pulmonary artery smooth muscle cells].
Topics: Animals; Calcium-Transporting ATPases; Cells, Cultured; Epoprostenol; Indomethacin; Muscle, Smooth, Vascular; Platelet Activating Factor; Pulmonary Artery; Rabbits; Thromboxane A2; Verapamil | 1996 |
Shigella dysenteriae type 1 toxin induced lipid peroxidation in enterocytes isolated from rabbit ileum.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antioxidants; Bacterial Toxins; Calcimycin; Calcium Channel Blockers; Dantrolene; Dysentery, Bacillary; Enterotoxins; Enzyme Inhibitors; Ileum; In Vitro Techniques; Indomethacin; Ionophores; Lipid Peroxides; Male; Muscle Relaxants, Central; Rabbits; Reactive Oxygen Species; Shiga Toxins; Shigella dysenteriae; Tetradecanoylphorbol Acetate; Verapamil | 1998 |
Role of arachidonic acid metabolites in the action of a beta adrenergic agonist on human monocyte phagocytosis.
Topics: Acetophenones; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Arachidonic Acid; Bucladesine; Calcium; Calcium Channel Blockers; Candida albicans; Cyclic AMP; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indomethacin; Isoproterenol; Monocytes; Oxytocics; Phagocytosis; Phospholipases A; Phospholipases A2; Propranolol; Prostaglandin-Endoperoxide Synthases; Receptors, Adrenergic, beta; Verapamil | 1998 |
Fenamates inhibit contraction of guinea-pig isolated bronchus in vitro independent of prostanoid synthesis inhibition.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Bronchi; Bronchoconstriction; Bronchoconstrictor Agents; Calcium; Dose-Response Relationship, Drug; Flufenamic Acid; Guinea Pigs; Indomethacin; Methacholine Chloride; ortho-Aminobenzoates; Prostaglandin Antagonists; Prostaglandins; Vasodilator Agents; Verapamil | 1998 |
Effects of hypoxia on pulmonary vascular contractility.
Topics: Animals; Blood Vessels; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Hypoxia; Indomethacin; Nitroarginine; Pulmonary Circulation; Rats; Tetraethylammonium; Vasoconstriction; Verapamil | 1998 |
Carrier mechanisms involved in the transepithelial transport of bis(POM)-PMEA and its metabolites across Caco-2 monolayers.
Topics: Adenine; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Epithelium; Humans; Indomethacin; Verapamil | 1998 |
Store-operated calcium influx in human gastric cells: role of endogenous prostaglandins.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Biological Transport; Calcium; Calcium Channel Blockers; Cell Communication; Cell Line; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Humans; Ibuprofen; Indomethacin; Lanthanum; Manganese; Nifedipine; Prostaglandin Antagonists; Thapsigargin; Verapamil | 1998 |
Positive inotropic, negative chronotropic, and coronary vasoconstrictor effects of acetylcholine in isolated rat hearts: role of muscarinic receptors, prostaglandins, protein kinase C, influx of extracellular ca2+, intracellular Ca2+ release, and endothel
Topics: Acetylcholine; Animals; Calcium; Calcium Channel Blockers; Endothelium, Vascular; Heart; In Vitro Techniques; Indomethacin; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Prostaglandins; Protein Kinase C; Rats; Rats, Wistar; Receptors, Muscarinic; Stimulation, Chemical; Vasodilator Agents; Verapamil | 1998 |
Long-term treatment with fluoxetine associates with peripheral effects on rat vas deferens contractility.
Topics: Adrenergic Agents; Animals; Antidepressive Agents, Second-Generation; Binding Sites; Calcium; Cyclooxygenase Inhibitors; Fluoxetine; Indomethacin; Isoproterenol; Ketanserin; Male; Muscle Contraction; Nitroprusside; Norepinephrine; Prazosin; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Vas Deferens; Verapamil | 1999 |
The multidrug resistance-associated protein (MRP) is over-expressed and functional in rat hepatoma cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Indomethacin; Liver Neoplasms, Experimental; Multidrug Resistance-Associated Proteins; Probenecid; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 1999 |
Effect of lysophosphatidic acid on the ovum transport in mouse oviducts.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Fallopian Tubes; Female; Indomethacin; Lysophospholipids; Mice; Mice, Inbred ICR; Ovum Transport; Pertussis Toxin; Verapamil; Virulence Factors, Bordetella | 1999 |
Relaxant action produced by sodium nitroprusside in guinea-pig tracheal muscle.
Topics: Animals; Atropine; Calcium; Cyclic GMP; Dinoprostone; Female; Fura-2; Guinea Pigs; Indoles; Indomethacin; Male; Muscle Relaxation; Nitroprusside; Terbutaline; Trachea; Verapamil | 1999 |
Mechanisms of big endothelin-1-induced diuresis and natriuresis : role of ET(B) receptors.
Topics: Animals; Calcium; Calcium Channel Blockers; Cardiovascular Agents; Cytosol; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Enzyme Inhibitors; Glomerular Filtration Rate; Indomethacin; Kidney; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Protein Precursors; Pyrrolidines; Rats; Rats, Wistar; Receptor, Endothelin B; Receptors, Endothelin; Urination; Verapamil | 2000 |
Mesenteric cyclooxygenase products after combined antihypertensive treatment in uninephrectomized SHRs.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Hypertension; Indoles; Indomethacin; Mesenteric Arteries; Myocardial Contraction; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Verapamil | 2000 |
Simultaneous occurrence of ipsilateral cluster headache and chronic paroxysmal hemicrania: a case report.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Cluster Headache; Humans; Indomethacin; Male; Migraine Disorders; Recurrence; Vasodilator Agents; Verapamil | 2000 |
Multidrug resistance protein 1 regulates lipid asymmetry in erythrocyte membranes.
Topics: 4-Chloro-7-nitrobenzofurazan; Aminocaproates; Aminocaproic Acid; Anti-Inflammatory Agents, Non-Steroidal; ATP-Binding Cassette Transporters; Cell Membrane; Erythrocytes; Fluorescent Dyes; Humans; Hydrolysis; Indomethacin; Lipid Bilayers; Microscopy, Electron; Multidrug Resistance-Associated Proteins; Phosphatidylcholines; Phospholipases A; Phospholipases A2; Phospholipids; Sphingomyelin Phosphodiesterase; Time Factors; Vasodilator Agents; Verapamil | 2000 |
Mechanisms of taxotere-related drug resistance in pancreatic carcinoma.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Docetaxel; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluorescent Dyes; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Indomethacin; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Paclitaxel; Pancreatic Neoplasms; Rhodamine 123; RNA, Messenger; Taxoids; Tubulin; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Verapamil | 2001 |
[Effect of yuanhua on isolated uterine strips in unpregnant rats].
Topics: Animals; Cyclooxygenase Inhibitors; Drugs, Chinese Herbal; Female; In Vitro Techniques; Indomethacin; Magnoliopsida; Muscle, Smooth; Plants, Medicinal; Rats; Rats, Wistar; Uterine Contraction; Uterus; Verapamil | 1998 |
Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine.
Topics: Diltiazem; Dose-Response Relationship, Drug; Drug Synergism; Estrenes; Flavonoids; Humans; In Vitro Techniques; Indomethacin; Kinetics; Mitogen-Activated Protein Kinases; Phosphorylation; Platelet Activating Factor; Platelet Activation; Platelet Aggregation; Pyrrolidinones; Serotonin; Thromboxane A2; Verapamil | 2001 |
Budesonide reduces multidrug resistance-associated protein 1 expression in an airway epithelial cell line (Calu-1).
Topics: Blotting, Western; Bronchodilator Agents; Budesonide; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Gene Expression Regulation; Humans; Indomethacin; Lung; Multidrug Resistance-Associated Proteins; Probenecid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Verapamil; Vincristine | 2002 |
The influence of P-glycoprotein on morphine transport in Caco-2 cells. Comparison with paclitaxel.
Topics: Analgesics, Opioid; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Buthionine Sulfoximine; Caco-2 Cells; Cyclosporine; Cyclosporins; Dose-Response Relationship, Drug; Genistein; Glutathione; Humans; Indomethacin; Morphine; Paclitaxel; Probenecid; Progesterone; Time Factors; Verapamil | 2002 |
The paroxysmal hemicrania-tic syndrome.
Topics: Aged; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Fructose; Humans; Indomethacin; Male; Middle Aged; Syndrome; Topiramate; Trigeminal Neuralgia; Vascular Headaches; Verapamil | 2003 |
Hemicrania continua with contralateral episodic cluster headache: a case report.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cluster Headache; Functional Laterality; Humans; Indomethacin; Male; Migraine Disorders; Serotonin Receptor Agonists; Sumatriptan; Vasodilator Agents; Verapamil | 2003 |
P-glycoprotein and multidrug resistance-associated protein mediate specific patterns of multidrug resistance in malignant glioma cell lines, but not in primary glioma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Endothelial Cells; Flow Cytometry; Glioma; Humans; Immunohistochemistry; Indomethacin; Multidrug Resistance-Associated Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rhodamine 123; RNA, Messenger; Tumor Cells, Cultured; Verapamil; Vincristine | 2003 |
Multidrug resistance protein-6 (MRP6) in human dermal fibroblasts. Comparison between cells from normal subjects and from Pseudoxanthoma elasticum patients.
Topics: Adult; Benzbromarone; Cell Count; Cell Division; Chlorambucil; Female; Fibroblasts; Fluoresceins; Fluorescent Dyes; Humans; Indomethacin; Lysosomes; Male; Membrane Transport Proteins; Microscopy, Fluorescence; Middle Aged; Multidrug Resistance-Associated Proteins; Propionates; Pseudoxanthoma Elasticum; Quinolines; Skin; Verapamil; Vinblastine | 2003 |
Signaling mechanisms mediated by G-protein coupled receptors in human platelets.
Topics: Adrenergic Agonists; Adrenergic alpha-2 Receptor Antagonists; Adult; Arachidonic Acid; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Drug Synergism; Epinephrine; Female; Flavonoids; Humans; Indomethacin; Male; Platelet Aggregation; Receptors, G-Protein-Coupled; Signal Transduction; Type C Phospholipases; Verapamil; Yohimbine | 2004 |
Involvement of thromboxane A2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation.
Topics: Benzoquinones; Blood Platelets; Calcimycin; Humans; Indomethacin; Ionophores; Lactams, Macrocyclic; Platelet Activating Factor; Platelet Aggregation; Protein-Tyrosine Kinases; Quinones; Rifabutin; Thromboxane A2; Verapamil | 2004 |
Hemicrania continua responsive to verapamil.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Female; Headache; Humans; Indomethacin; Treatment Outcome; Verapamil | 2005 |
Verapamil-responsive hemicrania continua in a patient with episodic cluster headache.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Cluster Headache; Female; Headache; Humans; Indomethacin; Verapamil | 2006 |
Apparent active transport of MDMA is not mediated by P-glycoprotein: a comparison with MDCK and Caco-2 monolayers.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Cell Line; Dogs; Humans; Indomethacin; N-Methyl-3,4-methylenedioxyamphetamine; Probenecid; Progesterone; Propionates; Quinolines; Rhodamine 123; Ritonavir; Verapamil | 2006 |
Effect of verapamil on nitric oxide synthase in a portal vein-ligated rat model: role of prostaglandin.
Topics: Animals; Epoprostenol; Hemodynamics; Hypertension, Portal; Indomethacin; Male; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Splanchnic Circulation; Verapamil | 2006 |
The role of tyrosine kinase in prostaglandin E2 and vanadate-evoked contractions in rabbit duodenum in vitro.
Topics: Animals; Calcium; Carbachol; Dinoprostone; Dose-Response Relationship, Drug; Duodenum; Estrenes; Genistein; In Vitro Techniques; Indomethacin; Muscle Contraction; Muscle, Smooth; Phosphorylation; Protein-Tyrosine Kinases; Pyrrolidinones; Rabbits; Tyrosine; Tyrphostins; Vanadates; Verapamil | 2006 |
Endothelium-dependent induction of vasorelaxation by the butanol extract of Phellinus igniarius in isolated rat aorta.
Topics: Animals; Aorta; Atropine; Butanols; Cyclic GMP; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Oxadiazoles; Polyporaceae; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation; Vasodilator Agents; Verapamil | 2006 |
Now dear, I have a headache! Immediate improvement of cluster headaches after sexual activity.
Topics: Cardiovascular Agents; Cluster Headache; Coitus; Female; Humans; Indomethacin; Male; Middle Aged; Orgasm; Oxygen Inhalation Therapy; Vasodilator Agents; Verapamil | 2006 |
Progesterone inhibits folic acid transport in human trophoblasts.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; ATP-Binding Cassette Transporters; Estradiol; Folic Acid; Humans; Indoles; Indomethacin; Kinetics; p-Aminohippuric Acid; Probenecid; Progesterone; Trophoblasts; Verapamil | 2007 |
Rhythmic contractility in the hepatic portal "corkscrew" vein of the rat snake.
Topics: Angiotensin II; Animals; Calcium; Catecholamines; Colubridae; Immunohistochemistry; Indomethacin; Liver; Ouabain; Portal Vein; Prostaglandins; Sodium-Potassium-Exchanging ATPase; Species Specificity; Vasoconstriction; Verapamil | 2009 |
Blood pressure-lowering and vascular modulator effects of Acorus calamus extract are mediated through multiple pathways.
Topics: Acetylcholine; Acorus; Animals; Aorta, Thoracic; Atropine; Blood Pressure; Caffeine; Dose-Response Relationship, Drug; Egtazic Acid; Endothelium, Vascular; Indomethacin; Inhibitory Concentration 50; Male; NG-Nitroarginine Methyl Ester; Norepinephrine; Phenylephrine; Plant Extracts; Plant Roots; Potassium Chloride; Rats; Rats, Sprague-Dawley; Reference Standards; Ryanodine; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Verapamil | 2009 |
Coexisting trigeminal autonomic cephalalgias and hemicrania continua.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Brain; Calcium Channel Blockers; Cluster Headache; Comorbidity; Diagnosis, Differential; Disease Progression; Female; Fructose; Humans; Indomethacin; Migraine Disorders; Time Factors; Topiramate; Treatment Outcome; Trigeminal Autonomic Cephalalgias; Verapamil | 2010 |
Effect of low concentrations of hydrogen peroxide on the contractile responses of rat detrusor smooth muscle strips.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetylcholine; Amides; Animals; Calcium; Dose-Response Relationship, Drug; Drug Synergism; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Phenylephrine; Pyridines; Rats; Rats, Sprague-Dawley; Time Factors; Urinary Bladder; Verapamil; Vitamin E | 2010 |
Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Fluoresceins; Fluorescent Dyes; Glyburide; Indomethacin; Intestine, Small; Male; Microtomy; Multidrug Resistance-Associated Proteins; Rats; Rats, Wistar; Verapamil; Xenobiotics | 2011 |
pH Sensitive graft copolymers for zero order drug release: a mechanistic analysis.
Topics: Chemistry, Pharmaceutical; Delayed-Action Preparations; Dicarboxylic Acids; Diffusion; Diltiazem; Dosage Forms; Epoxy Compounds; Hydrogen-Ion Concentration; Indomethacin; Methacrylates; Microspheres; Particle Size; Pharmacokinetics; Polyesters; Polymers; Solubility; Tablets; Verapamil | 2012 |
Hypotensive effect of Gentiana floribunda is mediated through Ca++ antagonism pathway.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Arginine; Atropine; Blood Pressure; Calcium; Cardiovascular Agents; Dose-Response Relationship, Drug; Endothelium, Vascular; Gentiana; Hypertension; Indomethacin; Male; Phenylephrine; Phytotherapy; Plant Extracts; Potassium; Rats; Rats, Sprague-Dawley; Signal Transduction; Vasoconstriction; Vasodilator Agents; Verapamil | 2012 |
15-PGDH inhibitors: the antiulcer effects of carbenoxolone, pioglitazone and verapamil in indomethacin induced peptic ulcer rats.
Topics: Animals; Anti-Ulcer Agents; Carbenoxolone; Gastric Acid; Gastric Mucosa; Hydroxyprostaglandin Dehydrogenases; Indomethacin; Male; Mucus; Peptic Ulcer; Pioglitazone; Rats; Stomach; Thiazolidinediones; Verapamil | 2013 |
In vivo epithelial wound repair requires mobilization of endogenous intracellular and extracellular calcium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Boron Compounds; Calcium; Calcium Channel Blockers; Calcium Signaling; Calcium-Transporting ATPases; Chelating Agents; Edetic Acid; Egtazic Acid; Estrenes; Gastric Mucosa; Indomethacin; Mice; Mice, Knockout; Phosphodiesterase Inhibitors; Pyrrolidinones; Verapamil; Wound Healing | 2013 |
A role for the sodium pump in H2O2-induced vasorelaxation in porcine isolated coronary arteries.
Topics: Animals; Bradykinin; Carbenoxolone; Catalase; Colforsin; Coronary Vessels; Female; Hydrogen Peroxide; In Vitro Techniques; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Ouabain; Oxadiazoles; Peptides; Polyethylene Glycols; Quinoxalines; Sodium-Potassium-Exchanging ATPase; Swine; Vasoconstrictor Agents; Vasodilation; Verapamil | 2014 |
β-Citronellol, an alcoholic monoterpene with inhibitory properties on the contractility of rat trachea.
Topics: Acyclic Monoterpenes; Analysis of Variance; Animals; Calcium Channel Blockers; Enzyme Inhibitors; Indomethacin; Inhibitory Concentration 50; Male; Monoterpenes; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Parasympatholytics; Rats, Wistar; Tetraethylammonium; Thapsigargin; Trachea; Verapamil | 2016 |
Shear stress-induced angiogenesis in mouse muscle is independent of the vasodilator mechanism and quickly reversible.
Topics: Angiogenesis Inducing Agents; Animals; Blood Pressure; Cromakalim; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Ethanol; Heart Rate; Indomethacin; Male; Mice; Muscle, Skeletal; Neovascularization, Physiologic; Nitric Oxide Synthase; Prazosin; Stress, Mechanical; Vasodilator Agents; Verapamil | 2016 |
Trigeminal autonomic cephalalgias in children and adolescents.
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Child; Child, Preschool; Diagnosis, Differential; Disease Management; Female; Humans; Indomethacin; Magnetic Resonance Imaging; Male; Trigeminal Autonomic Cephalalgias; Vasodilator Agents; Verapamil | 2018 |
Influence of flavonoids' lipophilicity on platelet aggregation.
Topics: Blood Platelets; Estrenes; Flavonoids; Humans; Indomethacin; Platelet Aggregation; Pyrrolidinones; Signal Transduction; Verapamil | 2019 |
Quercetin and resveratrol ameliorate nickel-mediated hypercontraction in isolated Wistar rat aorta.
Topics: Animals; Aorta; Aorta, Thoracic; Calcium Channels; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Indomethacin; NG-Nitroarginine Methyl Ester; Nickel; Nitric Oxide; Quercetin; Rats; Rats, Wistar; Reactive Oxygen Species; Resveratrol; Verapamil | 2022 |