verapamil has been researched along with idarubicin in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 21 (61.76) | 18.2507 |
| 2000's | 12 (35.29) | 29.6817 |
| 2010's | 1 (2.94) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Boogen, C; Lennartz, K; Müller, MR; Nowrousian, MR; Rajewsky, MF; Seeber, S | 1 |
| Berman, E; McBride, M | 1 |
| Cairo, MS; Sender, L; Toy, C; van de Ven, C | 1 |
| Davey, MW; Davey, RA; Hargrave, RM; Kidman, AD | 1 |
| Di Simone, D; Grassi, B; Malvaldi, G; Mattii, L; Petrini, M; Testi, R; Zaccaro, L | 1 |
| Belloc, F; Boiron, JM; Cony-Makhoul, P; Dubosc-Marchenay, N; Dumain, P; Fabères, C; Lacombe, F; Marit, G; Montastruc, M; Puntous, M | 1 |
| Baccarani, M; Cerno, M; Damiani, D; Melli, C; Michelutti, A; Michieli, M | 1 |
| Belloc, F; Boiron, JM; Cony-Makhoul, P; Dumain, P; Lacombe, F; Lopez, F; Mahon, FX; Marit, G; Montastruc, M; Puntous, M | 1 |
| Andreeff, M; Consoli, U; Griffin, M; Ling, YH; Mahadevia, R; Perez-Soler, R; Priebe, W; Zhao, S | 1 |
| Cooper, A; Duffy, PM; Hayes, MC; Smart, CJ | 1 |
| Davey, MW; Davey, RA; Hargrave, RM | 1 |
| Baguley, BC; Davey, MW; Davey, RA; Hargrave, RM; Harvie, RM; Su, GM | 1 |
| Bennis, S; Chapey, C; El Yamani, J; Faure, P; Fourche, J; Hu, YP; Robert, J | 1 |
| Faussat, AM; Marie, JP; Simonin, G; Zhou, DC; Zittoun, R | 1 |
| Garnier-Suillerot, A; Mankhetkorn, S | 1 |
| Bloem, AC; Lokhorst, HM; Roovers, DJ; van Vliet, M | 1 |
| Berti, E; Berti, T; Carrara, M; D'Ancona, S; Ragazzi, E | 1 |
| Garnier-Suillerot, A; Mankhetkorn, S; Teodori, E | 1 |
| Baccarani, M; Baraldo, M; Damiani, D; Ermacora, A; Fanin, R; Furlanut, M; Michieli, M; Pea, F; Russo, D | 1 |
| Gieseler, F; Kessel, M; Woodcock, BG | 1 |
| de Witte, T; Pennings, AH; Raymakers, RA; Smeets, ME; Vierwinden, G; Wessels, H | 1 |
| Lankelma, J; Westerhoff, HV; Wielinga, PR | 1 |
| Kasimir-Bauer, S; Scheulen, ME; Schröder, JK; Seeber, S | 1 |
| Anagnostopoulos, N; Androutsos, G; Galanopoulos, A; Kalmantis, T; Meletis, J; Paterakis, G; Rombos, Y; Sagriotis, A; Symeonidis, A; Tiniakou, M; Tsimberidou, AM; Yataganas, X; Zoumbos, N | 1 |
| Kang, W; Weiss, M | 3 |
| Barge, RM; Honders, MW; Spoelder, HE; Veuger, MJ; Willemze, R | 1 |
| Balestri, F; Biscardi, M; Budriesi, R; Caporale, R; Gavazzi, S; Grossi, A; Scappini, B; Teodori, E | 1 |
| Chen, SG; Li, GY; Liu, JZ; Wang, CB; Wang, LX; Zhang, B | 1 |
1 review(s) available for verapamil and idarubicin
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for verapamil and idarubicin
| Article | Year |
|---|---|
Cyclosporine diminishes multidrug resistance in K562/ADM cells and improves complete remission in patients with acute myeloid leukemia.
Topics: Adult; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Survival; Cyclosporine; Cytarabine; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; Fluorescent Dyes; Humans; Idarubicin; Inhibitory Concentration 50; K562 Cells; Leukemia, Myeloid, Acute; Male; Rhodamine 123; Time Factors; Treatment Outcome; Verapamil | 2009 |
32 other study(ies) available for verapamil and idarubicin
| Article | Year |
|---|---|
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Cytotoxicity of adriamycin, idarubicin, and vincristine in acute myeloid leukemia: chemosensitization by verapamil in relation to P-glycoprotein expression.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Colorimetry; Doxorubicin; Drug Resistance; Flow Cytometry; Humans; Idarubicin; Leukemia, Myeloid, Acute; Membrane Glycoproteins; Verapamil; Vincristine | 1992 |
Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells.
Topics: Cell Division; Daunorubicin; Drug Resistance; Humans; Idarubicin; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured; Verapamil | 1992 |
Effect of idarubicin and epirubicin on in vitro polymorphonuclear function: diminished superoxide radical formation compared to their parent compounds daunorubicin and doxorubicin.
Topics: Cyclosporins; Daunorubicin; Doxorubicin; Epirubicin; Free Radicals; Humans; Idarubicin; In Vitro Techniques; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Protein Kinase C; Superoxides; Verapamil | 1990 |
Development of drug resistance is reduced with idarubicin relative to other anthracyclines.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Survival; Drug Interactions; Drug Resistance, Multiple; Etoposide; Flow Cytometry; Humans; Idarubicin; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Tumor Cells, Cultured; Verapamil | 1995 |
Evaluation of resistance index of several anticancer agents on parental and resistant P-388 cell lines.
Topics: Animals; Biological Transport; DNA Replication; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Epirubicin; Idarubicin; In Vitro Techniques; Leukemia P388; Mice; Mitoxantrone; Tumor Cells, Cultured; Verapamil | 1995 |
Daunorubicin (DNR) accumulation in fresh leukemic cells: correlation with clinical and biological features.
Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Biological Transport; Bone Marrow; Bone Marrow Transplantation; Cytarabine; Daunorubicin; Female; Flow Cytometry; Humans; Idarubicin; Leukemia, Myeloid; Male; Middle Aged; Neoplastic Stem Cells; Stimulation, Chemical; Treatment Failure; Verapamil | 1994 |
D-verapamil downmodulates P170-associated resistance to doxorubicin, daunorubicin and idarubicin.
Topics: Adenocarcinoma; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Cell Survival; Colonic Neoplasms; Daunorubicin; Doxorubicin; Drug Interactions; Drug Resistance; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; Idarubicin; Leukemia-Lymphoma, Adult T-Cell; Membrane Glycoproteins; Tumor Cells, Cultured; Verapamil | 1993 |
Flow cytometric study of idarubicin and daunorubicin accumulation and the effect of verapamil in leukemic cell lines and fresh cells from patients with acute non-lymphoblastic leukemia.
Topics: Adolescent; Adult; Daunorubicin; Drug Resistance; Female; Flow Cytometry; Humans; Idarubicin; Leukemia, Myeloid, Acute; Male; Middle Aged; Time Factors; Tumor Cells, Cultured; Verapamil | 1994 |
The novel anthracycline annamycin is not affected by P-glycoprotein-related multidrug resistance: comparison with idarubicin and doxorubicin in HL-60 leukemia cell lines.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HL-60 Cells; Humans; Idarubicin; Molecular Structure; Neoplasm Proteins; Structure-Activity Relationship; Verapamil | 1996 |
Confocal microscopy of idarubicin localisation in sensitive and multidrug-resistant bladder cancer cell lines.
Topics: Antibiotics, Antineoplastic; Cell Nucleus; Drug Resistance, Multiple; Humans; Idarubicin; Microscopy, Confocal; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Verapamil | 1996 |
Comparison of drug accumulation in P-glycoprotein-expressing and MRP-expressing human leukaemia cells.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Buthionine Sulfoximine; Calcium Channel Blockers; Cyclosporins; Daunorubicin; Humans; Idarubicin; Leukemia, T-Cell; Multidrug Resistance-Associated Proteins; Rhodamine 123; Rhodamines; Tumor Cells, Cultured; Verapamil | 1996 |
The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro.
Topics: Acridines; Amsacrine; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Buthionine Sulfoximine; Cell Line; Cell Survival; Daunorubicin; Drug Resistance, Multiple; HL-60 Cells; Humans; Idarubicin; Leukemia; Paclitaxel; Phenotype; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured; Verapamil | 1997 |
Cellular pharmacology of lipophilic anthracyclines in human tumor cells in culture selected for resistance to doxorubicin.
Topics: Anthracyclines; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Division; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Idarubicin; Tumor Cells, Cultured; Verapamil | 1997 |
Effect of the multidrug inhibitor GG918 on drug sensitivity of human leukemic cells.
Topics: Acridines; Acute Disease; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Membrane Permeability; Drug Resistance, Multiple; Gene Expression; Humans; Idarubicin; Isoquinolines; Leukemia; Mitoxantrone; RNA, Messenger; RNA, Neoplasm; Tetrahydroisoquinolines; Tumor Cells, Cultured; Verapamil | 1997 |
The ability of verapamil to restore intracellular accumulation of anthracyclines in multidrug resistant cells depends on the kinetics of their uptake.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporine; Daunorubicin; Doxorubicin; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Synergism; Humans; Idarubicin; Leukemia; Tumor Cells, Cultured; Verapamil | 1998 |
Idarubicin overcomes P-glycoprotein-related multidrug resistance: comparison with doxorubicin and daunorubicin in human multiple myeloma cell lines.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Idarubicin; Multiple Myeloma; Tumor Cells, Cultured; Verapamil | 1999 |
A comparison of the modulation of antiblastics cytotoxicity by verapamil and dipyridamole in a human colon carcinoma cell line.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Colonic Neoplasms; Cyclophosphamide; Dipyridamole; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Humans; Idarubicin; Mitoxantrone; Neoplasm Proteins; Teniposide; Tumor Cells, Cultured; Verapamil; Vinblastine | 1999 |
Partial inhibition of the P-glycoprotein-mediated transport of anthracyclines in viable resistant K562 cells after irradiation in the presence of a verapamil analogue.
Topics: Anthracyclines; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytosol; Daunorubicin; Doxorubicin; Drug Resistance, Multiple; Humans; Idarubicin; K562 Cells; Photoaffinity Labels; Ultraviolet Rays; Verapamil | 1999 |
Multidrug resistance modulation in vivo: the effect of cyclosporin A alone or with dexverapamil on idarubicin pharmacokinetics in acute leukemia.
Topics: Cyclosporine; Drug Resistance, Multiple; Drug Therapy, Combination; Humans; Idarubicin; Leukemia, Myeloid, Acute; Time Factors; Verapamil | 1999 |
Influence of serum protein binding on the uptake and retention of idarubicin by sensitive and multidrug resistant human leukemic cells.
Topics: Anti-Arrhythmia Agents; Blood Proteins; Cell Line; Drug Resistance, Multiple; Humans; Hypersensitivity; Idarubicin; Leukemia; Protein Binding; Time Factors; Tumor Cells, Cultured; Verapamil | 1999 |
Triggering noncycling hematopoietic progenitors and leukemic blasts to proliferate increases anthracycline retention and toxicity by downregulating multidrug resistance.
Topics: Antibiotics, Antineoplastic; Antigens, CD34; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blast Crisis; Bone Marrow Cells; Cell Cycle; Cell Division; Cell Survival; Cells, Cultured; Daunorubicin; Drug Resistance, Multiple; Gene Expression Regulation; Hematopoietic Stem Cells; Humans; Idarubicin; Idoxuridine; Leukemia, Myeloid, Acute; Verapamil | 1999 |
The relative importance of passive and P-glycoprotein mediated anthracycline efflux from multidrug-resistant cells.
Topics: Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Biological Transport, Active; Cell Compartmentation; Cell Line; Cell Membrane Permeability; Daunorubicin; Digitonin; Doxorubicin; Drug Resistance, Multiple; Epirubicin; Humans; Idarubicin; Kinetics; Verapamil | 2000 |
In vitro effect of multidrug resistance modifiers on idarubicinol efflux in blasts of acute myeloid leukemia.
Topics: Antineoplastic Agents; Blast Crisis; Calcium Channel Blockers; Daunorubicin; Dihydropyridines; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Idarubicin; Leukemia, Myeloid, Acute; Tumor Cells, Cultured; Verapamil | 2000 |
Evaluation of the clinical relevance of the expression and function of P-glycoprotein, multidrug resistance protein and lung resistance protein in patients with primary acute myelogenous leukemia.
Topics: Acute Disease; Adolescent; Adult; Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bone Marrow Transplantation; Calcium Channel Blockers; Carbocyanines; Combined Modality Therapy; Cytarabine; Daunorubicin; Disease-Free Survival; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Fluoresceins; Fluorescent Dyes; Genistein; Humans; Idarubicin; Immunophenotyping; Leukemia, Myeloid; Male; Middle Aged; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Probenecid; Prognosis; Prospective Studies; Rhodamine 123; Survival Analysis; Tumor Cells, Cultured; Vault Ribonucleoprotein Particles; Verapamil | 2002 |
Influence of P-glycoprotein modulators on cardiac uptake, metabolism, and effects of idarubicin.
Topics: Algorithms; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclosporins; Daunorubicin; Heart; Idarubicin; In Vitro Techniques; Male; Myocardium; Rats; Rats, Sprague-Dawley; Stroke Volume; Verapamil | 2001 |
P-glycoprotein inhibitors enhance saturable uptake of idarubicin in rat heart: pharmacokinetic/pharmacodynamic modeling.
Topics: Algorithms; Amiodarone; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Depression, Chemical; Enzyme Inhibitors; Heart; Heart Rate; Idarubicin; In Vitro Techniques; Kinetics; Male; Models, Biological; Myocardium; Nonlinear Dynamics; Rats; Rats, Sprague-Dawley; Verapamil | 2002 |
Inactivation of deoxycytidine kinase and overexpression of P-glycoprotein in AraC and daunorubicin double resistant leukemic cell lines.
Topics: 2-Chloroadenosine; Alternative Splicing; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azacitidine; Biological Transport; Buthionine Sulfoximine; Calcium Channel Blockers; Cytarabine; Daunorubicin; Decitabine; Deoxyadenosines; Deoxycytidine Kinase; DNA Mutational Analysis; DNA, Neoplasm; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Glutathione; Humans; Idarubicin; Leukemia; Methotrexate; Neoplasm Proteins; Rats; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Verapamil | 2003 |
Modeling the metabolism of idarubicin to idarubicinol in rat heart: effect of rutin and phenobarbital.
Topics: Amiodarone; Animals; Antineoplastic Agents; Daunorubicin; Drug Design; Excitatory Amino Acid Antagonists; Heart; Idarubicin; Kinetics; Male; Phenobarbital; Rats; Rats, Sprague-Dawley; Rutin; Time Factors; Vasodilator Agents; Verapamil | 2003 |
Multidrug reverting activity toward leukemia cells in a group of new verapamil analogues with low cardiovascular activity.
Topics: Adult; Aged; Aged, 80 and over; Animals; Anti-Arrhythmia Agents; Antibiotics, Antineoplastic; Aorta; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Female; Guinea Pigs; Heart Atria; Humans; Idarubicin; K562 Cells; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Organ Culture Techniques; Verapamil | 2006 |