verapamil and haloperidol

verapamil has been researched along with haloperidol in 75 studies

Research

Studies (75)

Timeframe	Studies, this research(%)	All Research%
pre-1990	9 (12.00)	18.7374
1990's	15 (20.00)	18.2507
2000's	25 (33.33)	29.6817
2010's	25 (33.33)	24.3611
2020's	1 (1.33)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Topliss, JG; Yoshida, F	1
Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M	1
Pajeva, IK; Wiese, M	1
Chen, XL; Hendrix, J; Kang, J; Korolev, AM; Lysenkova, LN; Miroshnikova, OV; Pearlstein, RA; Preobrazhenskaya, M; Rampe, D; Shchekotikhin, AE; Vaz, RJ	1
Keserü, GM	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Bacsó, Z; Cianfriglia, M; Fenyvesi, F; Goda, K; Kappelmayer, J; Lustyik, G; Nagy, H; Szabó, G; Szilasi, M	1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD	1
Li, J; Rajamani, R; Reynolds, CH; Tounge, BA	1
Caron, G; Ermondi, G	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW	1
Abraham, MH; Acree, WE; Ibrahim, A	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Caron, G; Ermondi, G; Visentin, S	1
Ahman, M; Holmén, AG; Wan, H	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Chen, X; Lin, X; Skolnik, S; Wang, J	1
Claxton, CR; Curran, RE; Harradine, PJ; Hutchison, L; Littlewood, P; Martin, IJ	1
Sen, S; Sinha, N	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Freiwald, S; Jiang, Y; Jones, JP; Kaspera, R; Katayama, J; Lee, CA; Smith, E; Totah, RA; Walker, GS	1
Bills, GF; de Pedro, N; El Aouad, N; Genilloud, O; Goetz, MA; González-Menéndez, V; Martín, J; Ortiz-López, FJ; Pérez-Victoria, I; Platas, G; Reyes, F; Tormo, JR; Vicente, F	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, L; Fei, J; Mei, Y; Ren, S; Yan, SF; Zeng, J; Zhang, JZ	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Peters, JU	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Brouillette, WJ; Brown, GB; Zha, C	1
Artursson, P; Mateus, A; Matsson, P	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Bloomer, WD; Papadopoulou, MV; Rosenzweig, HS	1
Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S	1
Bertolucci, PH; De Andrade, LA; Ferraz, HB; Pereira, JS	1
De Beaurepaire, R	1
Brady, JP	1
Calder, LD; Karler, R; Partlow, LM; Turkanis, SA	1
Alessi, NE; Hsieh, PS; Walden, M	1
Damsma, G; de Vries, JB; Hofsteede, HM; Westerink, BH	1
Price, WA	1
Dill, PL; Duarte, TE; Nagourney, RA; Su, YZ; Weisenthal, LM	1
Freed, WJ; Grebb, JA; Shelton, RC	1
Bloom, DM; Nair, NP; Tourjman, SV	1
Pascarzi, GA; Price, WA	1
Boadle-Biber, MC	1
Chen, YH; Tsai, MC	1
Calder, L; Clikeman, J; Finnegan, KT; Karler, R; Wei, S	1
Altura, BM; Altura, BT; He, GQ; Zhang, A	1
Batrak, GN; Degtiar, VY; Hawryluk, BR; Luik, AI; Mogilevich, SE; Naydyenova, IY; Prokopenko, RA	1
Belorkar, NR; Khanzode, SD; Kharkar, VT; Mahakalkar, SM; Manekar, MS	1
Gilani, AH; Rashid, F; Saeed, SA; Shah, BH	1
Canchola-Martínez, E; Mercado-Sánchez, G; Rodríguez-Medina, MA; Vergara-Onofre, M	1
Guarneros, A; Sitges, M	1
Doğrul, A; Yeşilyurt, O	1
Amorim, SC; Costa, PG; Futuro-Neto, HA; Pires, JG; Ribeiro, CA; Saraiva, FP	1
Borrelli, F; Capasso, F; Capasso, R; Izzo, AA; Mascolo, N	1
Bishnoi, M; Chopra, K; Kulkarni, SK	1
Furutani, K; Inanobe, A; Kurachi, Y; Ohno, Y; Yamakawa, Y	1
Cai, W; Chen, G; Chen, Y; Gao, F; Huang, Z; Li, W; Liu, X; Shi, G; Xu, H; Zhang, Y; Zheng, F; Zheng, Y; Zhong, S	1
Bispo-da-Silva, LB; da Silveira, NS; de Oliveira-Silva, GL; Lamanes, Bde F; Prado, LC	1
Braun, F; Danker, T; Guenther, E; Silbernagl, N	1
Balsara, JJ; Gaonkar, RK; Malekar, AR	1

Reviews

3 review(s) available for verapamil and haloperidol

Article	Year
Polypharmacology - foe or friend? Journal of medicinal chemistry, 2013, Nov-27, Volume: 56, Issue:22 Topics: Animals; Communicable Diseases; Drug Evaluation, Preclinical; Drug Repositioning; Humans; Polypharmacology; Safety	2013
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
The pharmacology of stuttering: a critical review. The American journal of psychiatry, 1991, Volume: 148, Issue:10 Topics: Antipsychotic Agents; Benzodiazepines; Calcium Channel Blockers; Haloperidol; Humans; Parasympathomimetics; Research Design; Stuttering; Verapamil	1991

Trials

2 trial(s) available for verapamil and haloperidol

Article	Year
Antipsychotic effects of verapamil in schizophrenia. The Hillside journal of clinical psychiatry, 1987, Volume: 9, Issue:2 Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Haloperidol; Humans; Male; Middle Aged; Random Allocation; Schizophrenia; Verapamil	1987
Use of verapamil to treat negative symptoms in schizophrenia. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:5 Topics: Adult; Double-Blind Method; Haloperidol; Humans; Male; Middle Aged; Schizophrenia; Verapamil	1987

Other Studies

70 other study(ies) available for verapamil and haloperidol

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers. Journal of medicinal chemistry, 2002, Aug-29, Volume: 45, Issue:18 Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2002
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). Journal of medicinal chemistry, 2002, Dec-19, Volume: 45, Issue:26 Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine	2002
Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches. Bioorganic & medicinal chemistry letters, 2003, May-19, Volume: 13, Issue:10 Topics: Amino Acids, Aromatic; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indoles; Inhibitory Concentration 50; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation; Quantitative Structure-Activity Relationship; Structural Homology, Protein; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG	2003
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications, 2004, Mar-19, Volume: 315, Issue:4 Topics: Adenosine Triphosphatases; Animals; Anti-Bacterial Agents; Antibodies, Monoclonal; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding, Competitive; Calcium Channel Blockers; Cyclosporine; Detergents; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Flow Cytometry; Fluoresceins; Humans; Ivermectin; Mice; NIH 3T3 Cells; Substrate Specificity	2004
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents. Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18 Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2004
A two-state homology model of the hERG K+ channel: application to ligand binding. Bioorganic & medicinal chemistry letters, 2005, Mar-15, Volume: 15, Issue:6 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Ligands; Models, Biological; Models, Molecular; Potassium Channels, Voltage-Gated; Protein Binding; Protein Conformation	2005
Calculating virtual log P in the alkane/water system (log P(N)(alk)) and its derived parameters deltalog P(N)(oct-alk) and log D(pH)(alk). Journal of medicinal chemistry, 2005, May-05, Volume: 48, Issue:9 Topics: 1-Octanol; Alkanes; Hydrogen-Ion Concentration; Least-Squares Analysis; Mathematics; Models, Chemical; Models, Molecular; Solvents; Water	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7 Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results	2006
Air to lung partition coefficients for volatile organic compounds and blood to lung partition coefficients for volatile organic compounds and drugs. European journal of medicinal chemistry, 2008, Volume: 43, Issue:3 Topics: Air; Animals; Humans; Lung; Organic Chemicals; Probability; Rats; Tissue Distribution; Volatilization	2008
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers. European journal of medicinal chemistry, 2009, Volume: 44, Issue:5 Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship	2009
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs. Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6 Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry	2009
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Attenuation of intestinal absorption by major efflux transporters: quantitative tools and strategies using a Caco-2 model. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2 Topics: Adenosine; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Sub-Family B Member 4; ATP-Binding Cassette Transporters; Biological Transport; Caco-2 Cells; Chromatography, Liquid; Dibenzocycloheptenes; Diketopiperazines; Drug Discovery; Heterocyclic Compounds, 4 or More Rings; Humans; Intestinal Absorption; Mass Spectrometry; Models, Biological; Neoplasm Proteins; Pharmaceutical Preparations; Predictive Value of Tests; Propionates; Quinolines; Substrate Specificity	2011
Control and measurement of plasma pH in equilibrium dialysis: influence on drug plasma protein binding. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Blood Proteins; Buffers; Carbon Dioxide; Chemical Phenomena; Dialysis; Dogs; Drug Evaluation, Preclinical; Humans; Hydrogen-Ion Concentration; Macaca fascicularis; Mice; Osmolar Concentration; Pharmaceutical Preparations; Protein Binding; Rats; Reproducibility of Results	2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model. European journal of medicinal chemistry, 2011, Volume: 46, Issue:2 Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship	2011
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Identifying a selective substrate and inhibitor pair for the evaluation of CYP2J2 activity. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:5 Topics: Amiodarone; Astemizole; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Danazol; Drug Discovery; Drug Interactions; Enzyme Inhibitors; Humans; Hydroxylation; In Vitro Techniques; Methylation; Microsomes, Liver; Models, Biological; Molecular Structure; Substrate Specificity; Tandem Mass Spectrometry; Terfenadine	2012
Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica. Journal of natural products, 2012, Jun-22, Volume: 75, Issue:6 Topics: Amino Acids; Ascomycota; Calcium Channels, L-Type; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fermentation; Humans; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Peptides, Cyclic; Vasodilator Agents	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Discovery and characterization of novel, potent, and selective cytochrome P450 2J2 inhibitors. Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:1 Topics: Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Microsomes, Liver; Models, Molecular; Molecular Dynamics Simulation; Substrate Specificity	2013
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands. Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1 Topics: Ligands; Models, Molecular; Quantitative Structure-Activity Relationship; Voltage-Gated Sodium Channels	2014
A high-throughput cell-based method to predict the unbound drug fraction in the brain. Journal of medicinal chemistry, 2014, Apr-10, Volume: 57, Issue:7 Topics: Animals; Brain; Dialysis; HEK293 Cells; High-Throughput Screening Assays; Humans; Pharmaceutical Preparations; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization	2014
The antitubercular activity of various nitro(triazole/imidazole)-based compounds. Bioorganic & medicinal chemistry, 2017, 11-01, Volume: 25, Issue:21 Topics: Animals; Antitubercular Agents; Cell Line; Chlorocebus aethiops; Dose-Response Relationship, Drug; Humans; Imidazoles; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Nitro Compounds; Structure-Activity Relationship; Triazoles	2017
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives. European journal of medicinal chemistry, 2021, Nov-05, Volume: 223 Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones	2021
A study on the action of two calcium channel blockers (verapamil and flunarizine) upon an experimental model of tardive dyskinesia in rats. Arquivos de neuro-psiquiatria, 1992, Volume: 50, Issue:3 Topics: Animals; Apomorphine; Drug Evaluation, Preclinical; Dyskinesia, Drug-Induced; Flunarizine; Haloperidol; Male; Rats; Rats, Wistar; Stereotyped Behavior; Verapamil	1992
Treatment of neuroleptic-resistant mania and schizoaffective disorders. The American journal of psychiatry, 1992, Volume: 149, Issue:11 Topics: Antipsychotic Agents; Bipolar Disorder; Drug Synergism; Drug Therapy, Combination; Haloperidol; Humans; Lithium; Nifedipine; Psychotic Disorders; Verapamil	1992
Calcium channel blockers and behavioral sensitization. Life sciences, 1991, Volume: 49, Issue:2 Topics: Amphetamine; Animals; Calcium Channel Blockers; Diltiazem; Haloperidol; Male; Mice; Nifedipine; Stereotyped Behavior; Verapamil	1991
Nifedipine-haloperidol combination in the treatment of Gilles de la Tourette's syndrome: a case study. The Journal of clinical psychiatry, 1989, Volume: 50, Issue:3 Topics: Administration, Oral; Child; Drug Therapy, Combination; Haloperidol; Humans; Male; Nifedipine; Tourette Syndrome; Verapamil	1989
The significance of extracellular calcium for the release of dopamine, acetylcholine and amino acids in conscious rats, evaluated by brain microdialysis. Naunyn-Schmiedeberg's archives of pharmacology, 1988, Volume: 337, Issue:4 Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Amino Acids; Animals; Brain; Calcium; Calcium Channel Blockers; Dialysis; Dopamine; Haloperidol; Magnesium; Male; Neurotransmitter Uptake Inhibitors; Piperazines; Rats; Verapamil	1988
Perturbation of in vitro drug resistance in human lymphatic neoplasms by combinations of putative inhibitors of protein kinase C. Cancer treatment reports, 1987, Volume: 71, Issue:12 Topics: Cell Survival; Chlorpromazine; Drug Resistance; Drug Synergism; Haloperidol; Humans; Imipramine; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Lidocaine; Protein Kinase C; Tamoxifen; Tumor Cells, Cultured; Verapamil	1987
Diltiazem or verapamil prevents haloperidol-induced apomorphine supersensitivity in mice. Journal of neural transmission, 1987, Volume: 68, Issue:3-4 Topics: Amphetamine; Animals; Apomorphine; Behavior, Animal; Diltiazem; Drug Hypersensitivity; Haloperidol; Mice; Mice, Inbred Strains; Nifedipine; Verapamil	1987
Verapamil in refractory schizophrenia: a case report. Progress in neuro-psychopharmacology & biological psychiatry, 1987, Volume: 11, Issue:2-3 Topics: Adult; Chronic Disease; Drug Resistance; Drug Therapy, Combination; Haloperidol; Humans; Male; Schizophrenia; Schizophrenic Psychology; Verapamil	1987
Further studies on the role of calcium in the depolarization-induced activation of tryptophan hydroxylase. Effect of verapamil, Tetracaine, haloperidol and fluphenazine. Biochemical pharmacology, 1982, Aug-01, Volume: 31, Issue:15 Topics: Animals; Brain Stem; Buffers; Calcium; Enzyme Activation; Fluphenazine; Haloperidol; Male; Membrane Potentials; Potassium; Rats; Rats, Inbred Strains; Tetracaine; Tryptophan Hydroxylase; Verapamil	1982
Bursting firing of action potentials in central snail neurons elicited by d-amphetamine: role of the electrogenic sodium pump. Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology, 1995, Volume: 111, Issue:1 Topics: Action Potentials; Animals; Atropine; Dextroamphetamine; Dose-Response Relationship, Drug; Edetic Acid; Esophagus; Haloperidol; Hexamethonium; Magnesium; Neurons; Ouabain; Patch-Clamp Techniques; Phenobarbital; Potassium; Prazosin; Propranolol; Snails; Sodium; Sodium-Potassium-Exchanging ATPase; Temperature; Tubocurarine; Verapamil	1995
Effects of L-type calcium channel antagonists on the serotonin-depleting actions of MDMA in rats. Brain research, 1993, Feb-12, Volume: 603, Issue:1 Topics: 3,4-Methylenedioxyamphetamine; Animals; Brain Chemistry; Calcium Channel Blockers; Cerebral Cortex; Flunarizine; Haloperidol; Hippocampus; Male; Methamphetamine; N-Methyl-3,4-methylenedioxyamphetamine; Nifedipine; Rats; Rats, Sprague-Dawley; Seizures; Serotonin; Stereotyped Behavior; Verapamil	1993
Cocaine-induced cerebrovasospasm and its possible mechanism of action. The Journal of pharmacology and experimental therapeutics, 1994, Volume: 268, Issue:3 Topics: Animals; Biological Transport; Brain; Calcium; Cells, Cultured; Cocaine; Cyclooxygenase Inhibitors; Dogs; Dopamine; Dopamine Antagonists; Eicosanoids; Female; Haloperidol; Indomethacin; Ischemic Attack, Transient; Male; Muscle Contraction; Sheep; Swine; Verapamil	1994
Effects of haloperidol and chlorpromazine on smooth muscle contractility, platelet aggregation and neuronal calcium current. General physiology and biophysics, 1995, Volume: 14, Issue:4 Topics: Animals; Antipsychotic Agents; Butyrophenones; Calcium Channel Blockers; Calcium Channels; Calmodulin; Chlorpromazine; Droperidol; Electric Stimulation; Guinea Pigs; Haloperidol; In Vitro Techniques; Isometric Contraction; Male; Muscle, Smooth; Neurons; Phenothiazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Prazosin; Rats; Rats, Wistar; Snails; Sulpiride; Thrombin; Ureter; Verapamil	1995
Effect of pre-treatment of some calcium channel blockers on catalepsy and stereotypic behaviour in rats. Indian journal of physiology and pharmacology, 1996, Volume: 40, Issue:2 Topics: Animals; Calcium Channel Blockers; Catalepsy; Central Nervous System Depressants; Central Nervous System Stimulants; Diltiazem; Female; Haloperidol; Male; Methamphetamine; Nifedipine; Rats; Rats, Wistar; Stereotyped Behavior; Verapamil	1996
Dopamine potentiation of calcium ionophore, A-23187-induced platelet aggregation. Advances in experimental medicine and biology, 1997, Volume: 407 Topics: 3,4-Dihydroxyphenylacetic Acid; Alkaloids; Androstadienes; Aspirin; Benzophenanthridines; Calcimycin; Calcium; Chlorpromazine; Diltiazem; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; GTP-Binding Proteins; Haloperidol; Homovanillic Acid; Humans; Indomethacin; Ion Transport; Ionophores; Phenanthridines; Phentolamine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Aggregation; Propranolol; Protein Kinase C; Protein-Tyrosine Kinases; Receptors, Dopamine; Serotonin; Signal Transduction; Verapamil; Wortmannin	1997
[Inhibitors of calcium-calmodulin system and hypothalamic sex differentiation in rats. Biochemical parameters]. Ginecologia y obstetricia de Mexico, 1997, Volume: 65 Topics: Animals; Animals, Newborn; Antipsychotic Agents; Calcium Channel Blockers; Calmodulin; DNA; Dopamine Antagonists; Female; Haloperidol; Hypothalamus; Male; Organ Size; Ovary; Penfluridol; Pimozide; Proteins; Rats; RNA; Sex Differentiation; Testis; Trifluoperazine; Verapamil	1997
Chronic verapamil modifies striatal and frontal cortex dopamine levels. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1998, Volume: 8, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Methyltyrosine; Animals; Calcium Channel Blockers; Dopamine; Dopamine Antagonists; Frontal Lobe; Haloperidol; Hippocampus; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Neostriatum; Rats; Rats, Wistar; Serotonin; Verapamil	1998
Effects of Ca2+ channel blockers on apomorphine, bromocriptine and morphine-induced locomotor activity in mice. European journal of pharmacology, 1999, Jan-08, Volume: 364, Issue:2-3 Topics: Amlodipine; Animals; Apomorphine; Benzazepines; Bromocriptine; Calcium Channel Blockers; Diltiazem; Dopamine Antagonists; Female; Haloperidol; Heterocyclic Compounds, 4 or More Rings; Mice; Morphine; Motor Activity; Nicardipine; Time Factors; Verapamil	1999
Evidence of sex related differences in the effects of calcium channel blockers on neuroleptic-induced catalepsy in mice. Progress in neuro-psychopharmacology & biological psychiatry, 1999, Volume: 23, Issue:2 Topics: Animals; Antipsychotic Agents; Basal Ganglia Diseases; Calcium Channel Blockers; Catalepsy; Dose-Response Relationship, Drug; Female; Flunarizine; Haloperidol; Male; Mice; Nimodipine; Sex Factors; Verapamil	1999
Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro. Urology, 2004, Volume: 64, Issue:1 Topics: Acetylcholine; Adenosine Triphosphate; Animals; Anthracenes; Antidepressive Agents; Atropine; Bridged Bicyclo Compounds; Capsaicin; Depression; Electric Stimulation; Female; Haloperidol; Hypericum; Kaempferols; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Naloxone; Perylene; Phentolamine; Phloroglucinol; Piperidines; Plant Extracts; Propranolol; Pyrazoles; Quercetin; Rats; Rats, Wistar; Rimonabant; Rutin; Terpenes; Tetrodotoxin; Urinary Bladder; Urinary Incontinence; Verapamil	2004
Protective effect of L-type calcium channel blockers against haloperidol-induced orofacial dyskinesia: a behavioural, biochemical and neurochemical study. Neurochemical research, 2008, Volume: 33, Issue:9 Topics: Animals; Antioxidants; Antipsychotic Agents; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, L-Type; Corpus Striatum; Diltiazem; Dopamine; Haloperidol; Homovanillic Acid; Hydroxyindoleacetic Acid; Male; Movement Disorders; Nifedipine; Nimodipine; Random Allocation; Rats; Rats, Wistar; Serotonin; Verapamil	2008
Pharmacophore modeling for hERG channel facilitation. Biochemical and biophysical research communications, 2012, Feb-03, Volume: 418, Issue:1 Topics: Animals; Atenolol; Chlorpheniramine; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoxetine; Haloperidol; Humans; Hydrophobic and Hydrophilic Interactions; Imipramine; Metoprolol; Nortriptyline; Potassium Channel Blockers; Promethazine; Propranolol; Quantitative Structure-Activity Relationship; Sotalol; Terfenadine; Verapamil; Xenopus laevis	2012
N-n-butyl haloperidol iodide ameliorates cardiomyocytes hypoxia/reoxygenation injury by extracellular calcium-dependent and -independent mechanisms. Oxidative medicine and cellular longevity, 2013, Volume: 2013 Topics: Animals; Calcium; Cell Hypoxia; Cell Survival; Cyclic AMP; Cytoprotection; Early Growth Response Protein 1; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Extracellular Space; Haloperidol; L-Lactate Dehydrogenase; Myocardium; Myocytes, Cardiac; Oxygen; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Troponin I; Verapamil	2013
The aversive, anxiolytic-like, and verapamil-sensitive psychostimulant effects of pulegone. Biological & pharmaceutical bulletin, 2014, Volume: 37, Issue:5 Topics: Animals; Anti-Anxiety Agents; Central Nervous System Stimulants; Choice Behavior; Conditioning, Psychological; Cyclohexane Monoterpenes; Diltiazem; Drug Interactions; Flumazenil; Grooming; Haloperidol; Hand Strength; Male; Maze Learning; Menthol; Mice; Monoterpenes; Motor Activity; Picrotoxin; Reinforcement, Psychology; Rotarod Performance Test; Verapamil	2014
Catch and Patch: A Pipette-Based Approach for Automating Patch Clamp That Enables Cell Selection and Fast Compound Application. Assay and drug development technologies, 2016, Volume: 14, Issue:2 Topics: Animals; Automation; Cell Separation; Cells, Cultured; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Haloperidol; Humans; Patch-Clamp Techniques; Quinidine; Software; Structure-Activity Relationship; Time Factors; Verapamil	2016
EFFECTS OF VERAPAMIL ON DOPAMINE DEPENDENT BEHAVIOURS IN RATS. Indian journal of physiology and pharmacology, 1999, Volume: 43, Issue:1 Topics: Animals; Apomorphine; Avoidance Learning; Catalepsy; Dopamine; Haloperidol; Male; Rats; Receptors, Dopamine D2; Verapamil	1999