verapamil has been researched along with glyburide in 80 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (10.00) | 18.7374 |
| 1990's | 27 (33.75) | 18.2507 |
| 2000's | 31 (38.75) | 29.6817 |
| 2010's | 14 (17.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beauwens, R; Boom, A; Golstein, PE; Jacobs, P; Masereel, B; van Geffel, J | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Alvarez-Pedraglio, A; Colmenarejo, G; Lavandera, JL | 1 |
| Abe, T; Itoh, T; Kato, Y; Kusuhara, H; Meier, PJ; Shitara, Y; Sugiyama, D; Sugiyama, Y | 1 |
| Cavalli, A; De Ponti, F; Poluzzi, E; Recanatini, M | 1 |
| Casciano, CN; Clement, RP; Johnson, WW; Wang, EJ | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Caron, G; Ermondi, G; Visentin, S | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Campillo, NE; Guerra, A; Páez, JA | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Sen, S; Sinha, N | 1 |
| Caradonna, NP; Hallifax, D; Houston, JB; Turlizzi, E; Zanelli, U | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Barton, P; Ismair, M; Jupp, R; Riley, RJ; Soars, MG | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Huang, TF; Ko, FN; Su, MJ; Teng, CM; Wang, ML; Wu, TS; Yu, SM | 1 |
| Cooper, CW; Ishizuka, J; Murakami, M; Nickols, GA; Sumi, S; Thompson, JC; Townsend, CM | 1 |
| Briggs, JP; Brosius, FC; Furspan, PB; Lorenz, JN; Schnermann, J | 1 |
| Davidson, MB; Furman, A; Molnar, IG; Yamaguchi, D | 1 |
| Bang, L; Brønsgaard, AM; Nielsen-Kudsk, JE | 1 |
| Blaustein, MP; Rubin, LJ; Tod, ML; Yuan, XJ | 1 |
| Kumar, A; Lata, S; Saxena, KK; Saxena, RS; Srivastava, VK | 1 |
| Draznin, B; Kao, M; Sherman, N; Sussman, KE | 1 |
| Berg, M; Boyd, AE; Gaines, KL; Nelson, TY; Rajan, AS | 1 |
| Andersson, DE; Röjdmark, S | 1 |
| Beastall, GH; Buchanan, KD; Omile, C; Paterson, KR; Semple, CG | 1 |
| Ferrer, R; Soria, B | 1 |
| Draznin, B; Leitner, JW; Metz, SA; Sussman, KE | 1 |
| Draznin, B; Eckel, RH; Kao, M; Sherman, NA; Sussman, KE; Yost, T | 1 |
| Barbarino, A; De Marinis, L | 1 |
| McCulloch, AI; Randall, MD | 1 |
| Izawa, T; Izumi, H; Kasai, H; Ogawa, N; Okada, Y; Yokoyama, T | 1 |
| Benz, I; Kohlhardt, M | 1 |
| Gonzalez de la Fuente, P; Marthan, R; Savineau, JP | 1 |
| Hou, YS; Lee, SS; Teng, CM; Yu, SM | 1 |
| Cascio, WE; Engle, CL; Fleet, WF; Gettes, LS; Johnson, TA; Martin, DG; Shen, J | 1 |
| Gu, H; Hagiwara, N; Momma, K; Nakanishi, T | 1 |
| Dissing, S; Frøkjaer-Jensen, J; Gromada, J; Kofod, H | 1 |
| Gäbel, J; Lebrun, P; Malaisse, WJ; Pirotte, B; Rorsman, P; Valverde, I; Van Poelje, PD; Villanueva-Peñacarrillo, ML; Viñambres, C | 1 |
| Boucard, M; Hadjkaddour, K; Laurent, F; Michel, A | 1 |
| Goette, A; Honeycutt, C; Langberg, JJ | 1 |
| García-Segoviano, JA; Naranjo-Rodríguez, EB; Prieto-Gómez, B; Reyes-Vázquez, C; Trujillo-Santana, JT | 1 |
| Becq, F; Chimini, G; Hamon, Y; Luciani, MF; Rubartelli, A; Verrier, B | 1 |
| Antoine, MH; Cosgrove, KE; Dunne, MJ; Herchuelz, A; Kane, C; Lebrun, P; Ouedraogo, R; Pirotte, B | 1 |
| Kanellopoulos, A; Lenz, G; Mühlbauer, B | 1 |
| Cogolludo, AL; Pérez-Vizcaíno, F; Tamargo, J; Villamor, E | 1 |
| Backenköhler, U; Dörge, H; Heusch, G; Jalowy, A; Post, H; Schulz, R; Vahlhaus, C | 1 |
| Dong, C; Duffield, R; Ho, AK; Tang, T | 1 |
| Abdel-Zaher, AO | 1 |
| Gordon, EA; Guppy, LJ | 1 |
| Huang, DY; Osswald, H; Vallon, V | 1 |
| Kubota, I; Miyashita, T; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S | 1 |
| Athanatou, E; Hanrath, P; Robert, J; Schotten, U; Stellbrink, C; Zarse, M | 1 |
| Bodin, P; Burnstock, G | 1 |
| Bodin, P; Burnstock, G; De Groat, WC; Knight, GE | 1 |
| De Proft, R; Dejonghe, S; Gorus, F; Ling, Z; Pipeleers, D; Schuit, F; Winnock, F | 1 |
| Hobbs, EC; Luckie, DB; Maleszewski, JJ; Olson, LK; Wilterding, JH | 1 |
| Briaud, I; Dickson, LM; Lingohr, MK; Rhodes, CJ; Wrede, CE | 1 |
| Haruna, T; Horie, M; Kono, Y; Ninomiya, T; Takano, M | 1 |
| Ghayur, MN; Gilani, AH; Rohra, DK; Sarfraz, K; Sharif, HM; Zubairi, HS | 1 |
| Klein, J; Koren, G; Kraemer, J; Lubetsky, A | 1 |
| Dkhar, SA; Naveen, AT; Peddyreddy, MK; Ramaswamy, S; Shewade, DG | 1 |
| Cao, LH; Choi, DH; Kang, DG; Kim, JS; Kim, SJ; Lee, H; Lee, HS; Lee, JK | 1 |
| Kaku, K; Katsura, M; Matsuda, M; Ohkuma, S; Shigeto, M | 1 |
| Eiger, G; Goldberg, S; Patel, NP; Pugh, ME | 1 |
| Anger, G; Gedeon, C; Koren, G; Piquette-Miller, M | 1 |
| Heimberg, H; Ling, Z; Pipeleers, D; Wang, Q | 1 |
| Bercier, JP; Boudreault, L; Cifelli, C; Gong, B; Renaud, JM | 1 |
| Arayne, MS; Mirza, AZ; Sultana, N | 1 |
| Bertelli, E; Dragoni, S; Franco, G; Frosini, M; Gori, M; Possidente, M; Teodori, E; Valoti, M | 1 |
2 review(s) available for verapamil and glyburide
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for verapamil and glyburide
| Article | Year |
|---|---|
Effect of oral verapamil on glibenclamide stimulated insulin secretion.
Topics: Adult; C-Peptide; Glucagon; Glucose; Glyburide; Humans; Hypoglycemia; Insulin; Insulin Secretion; Male; Verapamil | 1986 |
77 other study(ies) available for verapamil and glyburide
| Article | Year |
|---|---|
P-glycoprotein inhibition by glibenclamide and related compounds.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Cell Adhesion; Cell Line; Cell Membrane; Cell Survival; Colchicine; Cystic Fibrosis Transmembrane Conductance Regulator; Glyburide; Humans; Hypoglycemic Agents; Immunochemistry; Opossums; Photoaffinity Labels; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Binding; Rats; Receptors, Drug; Sulfonylurea Compounds; Sulfonylurea Receptors | 1999 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Cheminformatic models to predict binding affinities to human serum albumin.
Topics: Adrenergic beta-Antagonists; Antidepressive Agents, Tricyclic; Chromatography, Affinity; Cyclooxygenase Inhibitors; Databases, Factual; Humans; Hydrophobic and Hydrophilic Interactions; Penicillins; Pharmaceutical Preparations; Protein Binding; Quantitative Structure-Activity Relationship; Reproducibility of Results; Serum Albumin; Steroids | 2001 |
Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.
Topics: Algorithms; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibiotics, Antitubercular; Antimalarials; Biological Transport, Active; Digoxin; Enzyme Inhibitors; Estradiol; Ibuprofen; LLC-PK1 Cells; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Quinidine; Quinine; Rats; Rifampin; Swine | 2002 |
Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cluster Analysis; Databases, Factual; Ether-A-Go-Go Potassium Channels; Long QT Syndrome; Models, Molecular; Molecular Conformation; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship | 2002 |
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Biological Transport, Active; Biomarkers; Cells, Cultured; Drug Interactions; Fluorescent Dyes; Humans | 2003 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship | 2008 |
GRIND-based 3D-QSAR and CoMFA to investigate topics dominated by hydrophobic interactions: the case of hERG K+ channel blockers.
Topics: Ether-A-Go-Go Potassium Channels; Humans; Hydrophobic and Hydrophilic Interactions; Models, Molecular; Potassium Channel Blockers; Quantitative Structure-Activity Relationship | 2009 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution | 2009 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Neural computational prediction of oral drug absorption based on CODES 2D descriptors.
Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2010 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Comparison of cryopreserved HepaRG cells with cryopreserved human hepatocytes for prediction of clearance for 26 drugs.
Topics: Cell Line, Tumor; Cryopreservation; Female; Hepatocytes; Humans; Male; Metabolic Clearance Rate; Pharmaceutical Preparations; Predictive Value of Tests | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.
Topics: Cell Line; Drug Discovery; Humans; Liver-Specific Organic Anion Transporter 1; Organic Anion Transporters | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Vasorelaxing effect in rat thoracic aorta caused by fraxinellone and dictamine isolated from the Chinese herb Dictamnus dasycarpus Turcz: comparison with cromakalim and Ca2+ channel blockers.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Alkaloids; Animals; Aorta, Thoracic; Benzofurans; Benzopyrans; Calcium; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Drugs, Chinese Herbal; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Norepinephrine; Potassium Channels; Potassium Chloride; Pyrroles; Quinolines; Rats; Rats, Inbred Strains; Verapamil | 1992 |
Role of extracellular magnesium in insulin secretion from rat insulinoma cells.
Topics: Animals; Calcium; Cell Line; Colforsin; Glyburide; Glyceraldehyde; Insulin; Insulin Secretion; Insulinoma; Kinetics; Magnesium; Pancreatic Neoplasms; Potassium Chloride; Rats; Tumor Cells, Cultured; Verapamil | 1992 |
Intracellular ATP can regulate afferent arteriolar tone via ATP-sensitive K+ channels in the rabbit.
Topics: Adenosine Triphosphate; Animals; Arterioles; Deoxyglucose; Diazoxide; Glyburide; In Vitro Techniques; Perfusion; Potassium Channels; Rabbits; Vasoconstriction; Verapamil | 1992 |
Glyburide-stimulated glucose transport in cultured muscle cells via protein kinase C-mediated pathway requiring new protein synthesis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Aminoquinolines; Animals; Biological Transport; Cells, Cultured; Cycloheximide; Glucose; Glyburide; Glycogen; Islets of Langerhans; Isoquinolines; Muscles; Piperazines; Potassium Channels; Protein Kinase C; Protein Kinase Inhibitors; Rats; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Glibenclamide blocks the relaxant action of pinacidil and cromakalim in airway smooth muscle.
Topics: Animals; Benzopyrans; Cromakalim; Female; Glyburide; Guanidines; Guinea Pigs; Histamine; In Vitro Techniques; Male; Muscle Relaxants, Central; Muscle Relaxation; Muscle, Smooth; Pinacidil; Pyrroles; Terbutaline; Theophylline; Trachea; Verapamil | 1990 |
Contrasting effects of hypoxia on tension in rat pulmonary and mesenteric arteries.
Topics: Animals; Benzopyrans; Cromakalim; Endothelium, Vascular; Glyburide; Hypoxia; In Vitro Techniques; Male; Mesenteric Arteries; Potassium; Pulmonary Artery; Pyrroles; Rats; Rats, Inbred Strains; Rest; Vasoconstriction; Vasodilator Agents; Verapamil | 1990 |
Modification of glybenclamide hypoglycaemia by verapamil in rabbits.
Topics: Animals; Blood Glucose; Drug Interactions; Female; Glyburide; Male; Rabbits; Verapamil | 1990 |
Relationship between cytosolic free calcium concentration and 2-deoxyglucose uptake in adipocytes isolated from 2- and 12-month-old rats.
Topics: Adipose Tissue; Aging; Animals; Calcium; Cytosol; Deoxy Sugars; Deoxyglucose; Glyburide; Insulin; Ion Channels; Kinetics; Male; Nitrendipine; Potassium; Rats; Rats, Inbred Strains; Verapamil | 1988 |
Increased cytosolic calcium. A signal for sulfonylurea-stimulated insulin release from beta cells.
Topics: Animals; Calcium; Cells, Cultured; Colforsin; Cricetinae; Cyclic AMP; Glyburide; Insulin; Islets of Langerhans; Tolbutamide; Verapamil | 1987 |
Influence of verapamil on human glucose tolerance.
Topics: Administration, Oral; Adult; Blood Glucose; Diabetes Mellitus, Type 2; Drug Synergism; Female; Glucose Tolerance Test; Glyburide; Humans; Infusions, Parenteral; Insulin; Male; Middle Aged; Verapamil | 1986 |
Graded spike electrogenesis in mouse pancreatic beta-cells.
Topics: Action Potentials; Animals; Caffeine; Cations, Divalent; Cell Membrane; Electric Conductivity; Glucose; Glyburide; Islets of Langerhans; Membrane Potentials; Tetrodotoxin; Verapamil | 1986 |
Glyburide increases cytosolic-free calcium concentrations in normal rat pancreatic islet cells.
Topics: Animals; Calcium; Cytosol; Glyburide; In Vitro Techniques; Insulin; Islets of Langerhans; Male; Rats; Rats, Inbred Strains; Verapamil | 1988 |
Possible role of cytosolic free calcium concentrations in mediating insulin resistance of obesity and hyperinsulinemia.
Topics: Adipose Tissue; Adult; Biopsy; Calcium; Cytosol; Deoxyglucose; Female; Glyburide; Humans; Hyperinsulinism; In Vitro Techniques; Insulin; Insulin Resistance; Obesity; Verapamil | 1988 |
Calcium antagonists and hormone release. I. Effects of verapamil on insulin release in normal subjects and patients with islet-cell tumor.
Topics: Adenoma, Islet Cell; Adolescent; Adult; Blood Glucose; Female; Glucagon; Glucose Tolerance Test; Glyburide; Humans; Insulin; Insulin Secretion; Male; Pancreatic Neoplasms; Reference Values; Verapamil | 1980 |
The involvement of ATP-sensitive potassium channels in beta-adrenoceptor-mediated vasorelaxation in the rat isolated mesenteric arterial bed.
Topics: Adenosine Triphosphate; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Albuterol; Animals; Binding, Competitive; Bucladesine; Dihydroalprenolol; Dobutamine; Glyburide; In Vitro Techniques; Isoproterenol; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channel Blockers; Potassium Channels; Radioligand Assay; Rats; Rats, Wistar; Terbutaline; Vasodilation; Vasodilator Agents; Verapamil | 1995 |
Effect of Kil769, a novel K(+)-channel opener, on sensitivity to Ca2+ of contractile elements and inositol phosphate formation in porcine coronary artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Calcium; Calcium Channel Blockers; Coronary Vessels; Dose-Response Relationship, Drug; Fura-2; Glyburide; Hydrolysis; In Vitro Techniques; Inositol Phosphates; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Potassium Channels; Prostaglandin Endoperoxides, Synthetic; Pyridines; Swine; Thromboxane A2; Vasoconstrictor Agents; Vasodilator Agents; Verapamil | 1995 |
Distinct modes of blockade in cardiac ATP-sensitive K+ channels suggest multiple targets for inhibitory drug molecules.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Binding Sites; Cells, Cultured; Glyburide; Imidazoles; Kinetics; Membrane Potentials; Myocardium; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels; Propanolamines; Rats; Sotalol; Verapamil | 1994 |
Cellular mechanisms of hypoxia-induced contraction in human and rat pulmonary arteries.
Topics: Aged; Animals; Benzopyrans; Calcium; Calcium Channels; Cromakalim; Glyburide; Humans; Hypoxia; In Vitro Techniques; Iodoacetates; Iodoacetic Acid; Male; Middle Aged; Muscle, Smooth, Vascular; Nifedipine; Potassium Channels; Pulmonary Artery; Pyrroles; Rats; Rats, Wistar; Vasoconstriction; Verapamil | 1995 |
Mechanisms of vasorelaxation induced by N-allylsecoboldine in rat thoracic aorta.
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Aorta, Thoracic; Aporphines; Benzopyrans; Calcium Channel Blockers; Cromakalim; Cyclic AMP; Cyclic GMP; Female; Glyburide; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; Phosphatidylinositols; Potassium; Pyrroles; Rats; Rats, Wistar; Vasodilator Agents; Verapamil | 1994 |
Marked activation delay caused by ischemia initiated after regional K+ elevation in in situ pig hearts.
Topics: Animals; Epinephrine; Female; Glyburide; Heart; Heart Conduction System; Male; Myocardial Ischemia; Myocardium; Potassium; Swine; Verapamil | 1994 |
Mechanisms of oxygen-induced contraction of ductus arteriosus isolated from the fetal rabbit.
Topics: Animals; Benzopyrans; Calcium; Cromakalim; Diltiazem; Ductus Arteriosus; Glyburide; In Vitro Techniques; Nickel; Norepinephrine; Oxygen; Potassium; Pyrroles; Rabbits; Vasoconstriction; Verapamil | 1993 |
Effects of the hypoglycaemic drugs repaglinide and glibenclamide on ATP-sensitive potassium-channels and cytosolic calcium levels in beta TC3 cells and rat pancreatic beta cells.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Calcium; Carbamates; Cell Line; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; Ion Channel Gating; Islets of Langerhans; Kinetics; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Rats; Serum Albumin; Time Factors; Verapamil | 1995 |
The riddle of formycin A insulinotropic action.
Topics: Adenosine; Animals; Calcium; Diabetes Mellitus, Type 2; Diazoxide; Female; Formycins; Glucose; Glyburide; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Ribonucleotides; Tubercidin; Verapamil; Xanthines | 1996 |
Smooth muscle relaxant activity of A1- and A2-selective adenosine receptor agonists in guinea pig trachea: involvement of potassium channels.
Topics: Adenosine; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Glyburide; Guinea Pigs; Hypoglycemic Agents; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Peptides; Potassium Channels; Receptors, Purinergic P1; Theobromine; Trachea; Verapamil | 1996 |
Electrical remodeling in atrial fibrillation. Time course and mechanisms.
Topics: Animals; Atrial Fibrillation; Calcium; Calcium Channel Blockers; Cardiac Pacing, Artificial; Dogs; Electrophysiology; Glyburide; Heart; Myocardium; Time Factors; Verapamil | 1996 |
Apamin blocks the direct relaxant effect of melatonin on rat ileal smooth muscle.
Topics: 4-Aminopyridine; Adrenergic alpha-Antagonists; Animals; Apamin; Calcium; Calcium Channel Blockers; Carbachol; Cholinergic Antagonists; Glyburide; Hexamethonium; Humans; Ileum; Male; Melatonin; Muscarinic Antagonists; Muscle Contraction; Neuromuscular Depolarizing Agents; Nitrendipine; Phentolamine; Rats; Rats, Wistar; Tetraethylammonium; Tetraethylammonium Compounds; Tetrodotoxin; Verapamil | 1997 |
Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acrylates; Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Caspase 1; Cells, Cultured; Cysteine Endopeptidases; Glyburide; Glycoproteins; Humans; Hypoglycemic Agents; Indoles; Interleukin-1; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred CBA; Monocytes; Oxindoles; Recombinant Proteins; Verapamil; Xenopus laevis | 1997 |
Verapamil, a phenylalkylamine Ca2+ channel blocker, inhibits ATP-sensitive K+ channels in insulin-secreting cells from rats.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Female; Gallopamil; Glucose; Glyburide; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Potassium Channel Blockers; Potassium Channels; Pyridines; Rats; Rubidium Radioisotopes; Thiadiazines; Verapamil | 1997 |
Stereoselective differences in the vasorelaxing effects of S(+) and R(-) ketamine on rat isolated aorta.
Topics: Anesthetics, Dissociative; Animals; Aorta; Calcium; Calcium Channel Blockers; Endothelium, Vascular; Glyburide; In Vitro Techniques; Ketamine; Norepinephrine; Rats; Rats, Sprague-Dawley; Stereoisomerism; Vasodilator Agents; Verapamil | 1998 |
Role of K+ channel opening and stimulation of cyclic GMP in the vasorelaxant effects of nicorandil in isolated piglet pulmonary and mesenteric arteries: relative efficacy and interactions between both pathways.
Topics: Animals; Cromakalim; Cyclic GMP; Enzyme Activation; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; In Vitro Techniques; Male; Mesenteric Arteries; Niacinamide; Nicorandil; Nitroprusside; Potassium Channels; Pulmonary Artery; Swine; Vasodilator Agents; Verapamil | 1998 |
Unique cardioprotective action of the new calcium antagonist mibefradil.
Topics: Amlodipine; Animals; Benzimidazoles; Calcium Channel Blockers; Glyburide; Heart; Heart Rate; Heart Ventricles; Mibefradil; Myocardial Infarction; Pressure; Swine; Tetrahydronaphthalenes; Verapamil | 1999 |
Protection of cardiomyocytes by pinacidil during metabolic inhibition and hyperkalemia.
Topics: Adenosine Triphosphate; Animals; Bepridil; Calcium; Calcium Channel Blockers; Cells, Cultured; Chick Embryo; Creatine Kinase; Glyburide; Homeostasis; Hyperkalemia; Myocardium; Pinacidil; Potassium Channels; Potassium Chloride; Sodium-Calcium Exchanger; Verapamil | 1999 |
The myoneural effects of lithium chloride on the nerve-muscle preparations of rats. Role of adenosine triphosphate-sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Antimanic Agents; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Diaphragm; Glyburide; Hypoglycemic Agents; In Vitro Techniques; Injections, Intravenous; Isotonic Contraction; KATP Channels; Lithium Chloride; Magnesium; Male; Muscle Contraction; Muscle, Skeletal; Neuromuscular Nondepolarizing Agents; Neurons; Paralysis; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Rats, Wistar; Verapamil; Water-Electrolyte Balance | 2000 |
Cardiomyopathic changes in streptozotocin-induced diabetes.
Topics: Adenosine Triphosphatases; Animals; Body Weight; Calcium Channel Blockers; Cardiomyopathies; Cardiotonic Agents; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Glyburide; Heart Rate; Hypoglycemic Agents; Isoproterenol; Male; Organ Size; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Verapamil | 1999 |
Sodium reabsorption in thick ascending limb of Henle's loop: effect of potassium channel blockade in vivo.
Topics: Adamantane; Animals; Barium; Cesium; Charybdotoxin; Dose-Response Relationship, Drug; Glyburide; Loop of Henle; Male; Models, Biological; Morpholines; Potassium; Potassium Channel Blockers; Potassium Channels; Quinine; Rats; Rats, Wistar; Sodium; Verapamil | 2000 |
4-aminopyridine inhibits the occurrence of ventricular fibrillation but not ventricular tachycardia in the reperfused, P6olated rat heart.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Glyburide; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Reperfusion; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Torsades de Pointes; Ventricular Fibrillation; Verapamil | 2000 |
Verapamil prevents stretch-induced shortening of atrial effective refractory period in langendorff-perfused rabbit heart.
Topics: Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Function; Calcium Channel Blockers; Cardiac Pacing, Artificial; Glyburide; Guanidines; In Vitro Techniques; Myocardial Contraction; Rabbits; Refractory Period, Electrophysiological; Sulfones; Time Factors; Verapamil | 2001 |
Evidence that release of adenosine triphosphate from endothelial cells during increased shear stress is vesicular.
Topics: Adenosine Triphosphate; ATP-Binding Cassette Transporters; Biological Transport; Calcium; Cells, Cultured; Endothelium, Vascular; Ethylmaleimide; Exocytosis; Glyburide; Humans; Infant, Newborn; Kinetics; Microscopy, Fluorescence; Monensin; Quinacrine; Secretory Vesicles; Stress, Mechanical; Umbilical Veins; Verapamil | 2001 |
ATP is released from guinea pig ureter epithelium on distension.
Topics: Adenosine Triphosphate; Animals; Brefeldin A; Calcium Channel Blockers; Exocytosis; Firefly Luciferin; Gadolinium; Glyburide; Guinea Pigs; Hypoglycemic Agents; In Vitro Techniques; Ionophores; Luciferases; Male; Microscopy, Electron, Scanning; Monensin; Nociceptors; Protein Synthesis Inhibitors; Ureter; Urothelium; Verapamil | 2002 |
Correlation between GABA release from rat islet beta-cells and their metabolic state.
Topics: 1-Methyl-3-isobutylxanthine; 2,4-Dinitrophenol; Adenosine Triphosphate; Animals; Calcium; Culture Media, Conditioned; Cycloheximide; Diazoxide; gamma-Aminobutyric Acid; Glucagon; Glucagon-Like Peptide 1; Glucose; Glutamate Decarboxylase; Glyburide; Islets of Langerhans; Male; Mannoheptulose; Oxidation-Reduction; Peptide Fragments; Protein Precursors; Rats; Rats, Wistar; Verapamil | 2002 |
Extracellular acidification parallels insulin secretion in INS-1 and HIT-T15 beta-cell lines.
Topics: Animals; Calcium Channel Blockers; Cell Line; Dose-Response Relationship, Drug; Glucose; Glyburide; Hydrogen-Ion Concentration; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Pancreas; Potassium; Potassium Chloride; Rats; Time Factors; Verapamil | 2002 |
Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
Topics: Animals; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucagon-Like Peptides; Glucose; Glyburide; Humans; Islets of Langerhans; Isoquinolines; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Peptide Fragments; Phosphorylation; Proto-Oncogene Proteins c-raf; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Sulfonamides; Verapamil | 2003 |
Verapamil, a Ca2+ entry blocker, targets the pore-forming subunit of cardiac type KATP channel (Kir6.2).
Topics: Calcium Channel Blockers; Cells, Cultured; Electrophysiology; Glyburide; Hypoglycemic Agents; Molecular Biology; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Verapamil | 2003 |
Acidosis-induced relaxation of human internal mammary artery is due to activation of ATP-sensitive potassium channels.
Topics: Acidosis; Adenosine Triphosphate; Calcium; Glyburide; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Mammary Arteries; Potassium Channels; Vasoconstriction; Vasodilation; Vasodilator Agents; Verapamil | 2005 |
Perfusion studies of glyburide transfer across the human placenta: implications for fetal safety.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Female; Fetus; Glyburide; Humans; Hypoglycemic Agents; In Vitro Techniques; Maternal-Fetal Exchange; Placenta; Pregnancy; Verapamil | 2006 |
An inherent acceleratory effect of insulin on small intestinal transit and its pharmacological characterization in normal mice.
Topics: Animals; Atropine; Calcium Channels; Clonidine; Gastrointestinal Transit; Glyburide; Insulin; Insulin Secretion; Intestine, Small; Male; Mice; Naloxone; Ondansetron; Receptors, Opioid; Verapamil | 2006 |
Endothelium-dependent induction of vasorelaxation by the butanol extract of Phellinus igniarius in isolated rat aorta.
Topics: Animals; Aorta; Atropine; Butanols; Cyclic GMP; Diltiazem; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Glyburide; In Vitro Techniques; Indomethacin; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Oxadiazoles; Polyporaceae; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Tetraethylammonium; Vasodilation; Vasodilator Agents; Verapamil | 2006 |
First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx.
Topics: Animals; Calcium; Calcium Isotopes; Cell Line, Tumor; Cell Survival; Dantrolene; Diazoxide; Dose-Response Relationship, Drug; Extracellular Fluid; Glucose; Glyburide; Insulin; Insulin Antagonists; Insulin Secretion; Insulin-Secreting Cells; L-Lactate Dehydrogenase; Male; Mice; Potassium Channels; Sodium Channels; Tetrodotoxin; Tolbutamide; Verapamil | 2006 |
Hyperinsulinemic euglycemia therapy for verapamil poisoning: case report.
Topics: Antidotes; Captopril; Critical Care; Drug Combinations; Female; Glyburide; Humans; Hyperinsulinism; Hypoglycemic Agents; Insulin; Middle Aged; Poisoning; Treatment Outcome; United States; Verapamil | 2007 |
Breast cancer resistance protein: mediating the trans-placental transfer of glyburide across the human placenta.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Female; Glyburide; Humans; Hypoglycemic Agents; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Placenta; Verapamil | 2008 |
Glibenclamide activates translation in rat pancreatic beta cells through calcium-dependent mTOR, PKA and MEK signalling pathways.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Signaling; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; Glyburide; Hypoglycemic Agents; Immunosuppressive Agents; Insulin-Secreting Cells; Male; Mitogen-Activated Protein Kinases; Protein Biosynthesis; Rats; Rats, Wistar; Sirolimus; Transcription Factors; Verapamil | 2008 |
Contractile dysfunctions in ATP-dependent K+ channel-deficient mouse muscle during fatigue involve excessive depolarization and Ca2+ influx through L-type Ca2+ channels.
Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Dose-Response Relationship, Drug; Glyburide; Hypoglycemic Agents; Mice; Mice, Knockout; Muscle Contraction; Muscle Fatigue; Muscle, Skeletal; Potassium Channels, Inwardly Rectifying; Verapamil | 2008 |
Simultaneous determination of gliquidone, pioglitazone hydrochloride, and verapamil in formulation and human serum by RP-HPLC.
Topics: Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Glyburide; Humans; Linear Models; Pioglitazone; Reproducibility of Results; Sensitivity and Specificity; Sulfonylurea Compounds; Tablets; Thiazolidinediones; Verapamil | 2011 |
Rat intestinal precision-cut slices as an in vitro model to study xenobiotic interaction with transporters.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP-Binding Cassette Transporters; Fluoresceins; Fluorescent Dyes; Glyburide; Indomethacin; Intestine, Small; Male; Microtomy; Multidrug Resistance-Associated Proteins; Rats; Rats, Wistar; Verapamil; Xenobiotics | 2011 |